Journals International Archives of Alle...

International Archives of Allergy and Immunology
Pier Giorgio Puzzovio, Bruce D Levy, Francesca Levi-Schaffer
BACKGROUND: CD300a is an inhibitory receptor (IR) expressed on several leukocytes, including mast cells (MCs) and macrophages (MΦ), important cells in allergic inflammation (AI). We have previously characterized CD300a role on MCs and in vivo in mouse models of allergy, in which the absence of CD300a resulted in increased inflammatory features and delayed resolution. However, the exact mechanism of this delayed resolution is unclear. Our hypothesis is that MΦ, important players in resolution, might be impaired when CD300a is absent...
March 16, 2023: International Archives of Allergy and Immunology
Luis Alfredo González Guzmán, Ramón Núñez Orjales, Manuel Boquete Paris, Carlos Pastor-Vargas, Borja Bartolome, Francisco Carballada González
INTRODUCTION: Cow epithelium allergy (CEA) has been described in workers highly exposed to cattle, such as farmers and veterinarians, being a health problem in this population since it is their main livelihood. This study aimed to characterize the main clinical manifestations and define the sensitization profile of the cow epithelium-allergic population treated in our health area. METHODS: This is a retrospective study including a total of 34 patients with a clinical diagnosis of CEA, confirmed by skin tests, bovine epithelium-specific IgE levels and allergen-specific conjunctival challenge test in some cases...
March 15, 2023: International Archives of Allergy and Immunology
Tannaz Abbasi-Dokht, Arefe Vafaeinezhad, Negin Khalesi, Farhad Malek, Dariush Haghmorad, Rasoul Baharlou
INTRODUCTION: The prevalence of coronavirus disease 2019 (COVID-19) has rapidly increased worldwide. More investigation is needed to progress toward understanding the exact role of immune responses in the pathology of the disease, leading to improved anticipation and treatment options. METHODS: In the present study, we examined the relative expression of T-bet, GATA3, RORγt, and FoxP3 transcription factors as well as laboratory indicators in 79 hospitalized patients along with 20 healthy subjects as a control group...
March 8, 2023: International Archives of Allergy and Immunology
Catherine Prattico, Pasquale Mulé, Moshe Ben-Shoshan
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food-induced hypersensitivity disorder that occurs mostly in infants. Long considered a rare disease, a recent increase in physician awareness and publication of diagnosis of guidelines has resulted in an increase in recognized FPIES cases. We aimed to conduct a systematic review of FPIES studies in the past 10 years. A search was conducted on PubMed and Embase in March 2022. Our systematic review focused on 2 domains: (1) the most reported FPIES food triggers; and (2) the resolution rate and median age at resolution of patients with FPIES...
March 7, 2023: International Archives of Allergy and Immunology
Hongfei Lou, Yanran Huang, Xiaohan Chu, Yang Wang, Chengshuo Wang, Luo Zhang
INTRODUCTION: Macrophages play a central role in balancing the immune response by switching phenotypes between the M1 and M2 profiles according to a delicate equilibrium. Based on a previous clinical trial (NCT03649139), this study aimed to evaluate the change in M2 macrophages during pollen exposure in seasonal allergic rhinitis (SAR). METHODS: Nasal symptom scores were recorded. Peripheral M2 macrophages were investigated according to cell surface markers, and M2-associated cytokine/chemokine release in serum and nasal secretion were assessed...
March 7, 2023: International Archives of Allergy and Immunology
Sevgi Sipahi Cimen, Zeynep Hizli Demirkale, Esra Yucel, Deniz Ozceker, Ayse Suleyman, Ugurcan Sayili, Zeynep Tamay, Nermin Guler
INTRODUCTION: Beta-lactam (BL) antibiotics are the most often involved drugs in allergic reactions. Mild cutaneous reactions such as maculopapular exanthema or urticaria are the most common presenting complaints of BL allergy in the pediatric population. However, it can be challenging to distinguish BL-induced allergy from reactions due to infections or other reasons. In this study, we aimed to determine the clinical characteristics and potential risk factors of true BL allergy in children with suspected mild cutaneous reactions to BLs...
March 1, 2023: International Archives of Allergy and Immunology
Mei-Ling Bu, Meng-Hui Li, Mei Feng, Jin-Rong Wang, Lifeng Sun
INTRODUCTION: Respiratory viral infection in childhood is closely associated with asthmatic attacks. Of all predisposing factors, viral infection is the primary contributor to acute childhood asthma exacerbations. However, the mechanisms involved in viral asthma are unclear. This study attempted to provide insights into molecular mechanisms in respiratory virus-induced acute asthma exacerbations. METHODS: House dust mite (HDM) was given by intranasal administration to induce asthma in mice...
February 23, 2023: International Archives of Allergy and Immunology
Dong Wang, Chie Ito, Yuji Homma, Michinori Arimitsu, Hajime Yoshisue
INTRODUCTION: Although the prevalence and burden of asthma are continuously increasing, there is a lack of evidence on the landscape of moderate-to-severe asthma in Japan. Here, we report the prevalence of moderate-to-severe asthma and describe patient's demographics and clinical characteristics from 2010 to 2019 using the JMDC claims database. METHODS: Patients (≥12 years) from the JMDC database with ≥2 asthma diagnoses in 2 different months in each index year were stratified as moderate-to-severe asthma based on the definition of asthma prevention and management guideline (Japanese Guidelines for Asthma, JGL) or Global Initiative for Asthma (GINA)...
February 16, 2023: International Archives of Allergy and Immunology
Ling Ma, Yunping Deng, Kanghua Wang, Jianbo Shi, Yueqi Sun
INTRODUCTION: Chronic rhinosinusitis with nasal polyps (CRSwNPs) in China is characterized by a mixed eosinophilic-neutrophilic inflammation, linking to a more heterogeneous clinical phenotype. However, the relationship between eosinophilic and neutrophilic inflammation in Chinese patients with CRSwNP remains largely unknown. We aimed to further characterize the correlation between neutrophils with eosinophils in relation to clinical characters and disease control status after endoscopic sinus surgery (ESS)...
February 6, 2023: International Archives of Allergy and Immunology
Rong Zhang, Lan Zhang, Peishan Li, Kaiyun Pang, Huixia Liu, Li Tian
As the first line of defense against risk factors, the nasal epithelial barrier maintains homeostasis in nasal mucosa. The composition of the epithelial barrier contains physical, chemical, immune, and microbiological barriers. Together, these barriers form the nasal defense against irritations. Risk factors from both internal and external environments can disrupt them. External risk factors contain allergens containing proteases, bacteria, virus, particulate matter, diesel exhaust particles, and cigarette smoke...
February 1, 2023: International Archives of Allergy and Immunology
Jingwei Du, Lijuan Peng, Jun Feng, Tao Zhang
INTRODUCTION: Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa, the incidence of which can reach 10-30% worldwide. RBCK1 (RANBP2-type and C3HC4-type zinc finger-containing 1) is a protein found in nasal epithelial cells; however, its function is not fully understood. METHODS: In this study, RT-qPCR and Western blotting were used to detect RBCK1 expression in the nasal epithelial tissues of AR and non-AR patients. Next, an AR cell model was established by using the house dust mite allergen (Derp1), and the model cells were then transfected with RBCK1 or NLRP3 overexpression plasmids...
January 26, 2023: International Archives of Allergy and Immunology
Changyi Xu, Lijuan Du, Yubiao Guo, Yuxia Liang
INTRODUCTION: circRNA played a role in a variety of diseases. This paper aimed to explore the differentially expressed circRNA in induced sputum cells of asthma patients, so as to provide new potential biomarkers and new ideas for the study of asthma. METHODS: All subjects were from the First Affiliated Hospital of Sun Yat-sen University. Differentially expressed circRNAs of asthma patients were screened by high-throughput sequencing. qRT-PCR was used to verify the expression of differential circRNAs...
January 23, 2023: International Archives of Allergy and Immunology
Juan Yuan, Ruina Li, He Song, Xi Liu
INTRODUCTION: Influenza A virus (IAV) infection causes severe lung inflammation and injury, particularly in children. Sirtuin3 (Sirt3) was confirmed to be effective in protecting the lung against injury. This study aims to explore the function and mechanism of Sirt3 on influenza development in children. METHODS: The Sirt3 level in serum samples from IAV-infected children and lung epithelial cells were detected using RT-qPCR, ELISA, and Western blot assays. Cell viability and apoptosis were determined by MTT and flow cytometry assays...
January 19, 2023: International Archives of Allergy and Immunology
Albert Roger, Carlota Lazo, Noelia Arias, Bibiana Quirant, Nereida Albert, Mireia Gómez, Waleska Schayman
INTRODUCTION: Sensitization to cat and dog allergens is common in patients with allergic respiratory diseases. The study objective was to determine the prevalence of immunoglobulin E (IgE) sensitization to specific cat and dog allergens using component-resolved diagnosis (CRD) in patients with allergic respiratory diseases plus cat and/or dog sensitization. METHODS: We included 87 patients aged 8-62 years, diagnosed with allergic asthma and/or rhinitis plus cat and/or dog sensitization, and attended at the allergy section of a tertiary hospital in Badalona (Catalonia, Spain)...
January 19, 2023: International Archives of Allergy and Immunology
Ryo Okuda, Tamiko Takemura, Tomohisa Baba, Eri Hagiwara, Koji Okudela, Takashi Ogura
INTRODUCTION: The accuracy of serum immunoglobulin (Ig) G testing for diagnosis of stable bird-related fibrotic hypersensitivity pneumonitis (HP) is controversial. Furthermore, avian serum, extracts, or feathers were employed as antigens in bird-related HP; however, the usage of egg whites has not been reported. We investigated the utility of IgG testing against pigeon egg whites in patients with stable bird-related fibrotic HP. METHODS: Patients having a positive inhalation test for pigeon antigen and a histological investigation with diagnostic confidence of fibrotic HP greater than moderate confidence were included...
January 18, 2023: International Archives of Allergy and Immunology
Murat Türk, Ragıp Ertaş, Ümit Murat Şahiner, Pavel Kolkhir, Bülent Enis Şekerel, Özge Soyer, Atıl Avcı, Mustafa Atasoy, Kemal Özyurt, Yekta Türk, Engin Zeydan, Marcus Maurer
INTRODUCTION: The use of predictors of response to a specific treatment in patients with chronic spontaneous urticaria (CSU) can improve disease management, help prevent unnecessary healthcare costs, and save time. In this study, we aimed to identify predictors of complete response to standard-dosed and higher than standard-dosed antihistamine treatments in patients with CSU. METHODS: Medical records of 475 CSU patients, 120 of them <18 years old, from 3 different centers were analyzed...
January 18, 2023: International Archives of Allergy and Immunology
Pascal Ickrath, Lisa Sprügel, Niklas Beyersdorf, Lukas Haug, Agmal Scherzad, Rudolf Hagen, Stephan Hackenberg
INTRODUCTION: Aspergillus fumigatus belongs to the saprophytic fungi, and its spores form a significant part of the daily load of fungal spores inhaled as particles in aerosols. A. fumigatus is a possible T-cell activator. Its contribution to the pathogenesis of chronic rhinosinusitis (CRS) is controversially discussed. The aim of this study was to detect and characterize A. fumigatus-specific CD4+ and CD8+ T cells in patients with CRS with (CRSwNP) and without (CRSsNP) nasal polyps. METHODS: Tissue and blood samples were collected from patients who underwent paranasal sinus surgery due to CRSwNP or CRSsNP...
January 18, 2023: International Archives of Allergy and Immunology
Hua Feng, Xiujuan Xiong, Zhuo Chen, Qunying Xu, Zhongwei Zhang, Nan Luo, Yongning Wu
INTRODUCTION: This study was conducted to evaluate the prevalence and influencing factors of food allergy (FA) in different regions and populations. METHODS: The studies from January 2011 to December 2021 were searched through PubMed, Embase, Cochrane Library, and Web of Science databases. The prevalence of FA was evaluated by calculating the pooled effect estimates and their 95% confidence intervals (CIs). The odds ratio (OR) value was used to investigate the influencing factors of FA...
January 12, 2023: International Archives of Allergy and Immunology
Lixia Hao, Juan Ren, Yanlin Zhu, Yanping Ma, Jie Pan, Linhua Yang
INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by excessive inflammatory responses. This study explored the association between laboratory characteristics and outcomes in adult patients with HLH. METHODS: The adult patients diagnosed with HLH at the Second Hospital of Shanxi Medical University from September 2016 to September 2021 were retrospectively analyzed in this study. RESULTS: A total of 90 HLH patients were included...
January 12, 2023: International Archives of Allergy and Immunology
Yesenia Peña-Acevedo, Ana Rosado-Ingelmo, Wendy Vargas Porras, Marianela Brandoni-Petrone, Miguel A Tejedor-Alonso
INTRODUCTION: The drug provocation test (DPT) is the gold standard for the drug allergy workup; however, it is not free from severe adverse reactions. Our aim was to obtain robust data that predict a reaction during or after the DPT at the first contact with the patient in the allergy outpatient clinic. METHODS: The population of this cross-sectional study comprised all patients undergoing a drug allergy workup (clinical assessment, specific IgE, or skin tests, or DPT) at University Hospital Fundacion Alcorcon in 2016...
January 12, 2023: International Archives of Allergy and Immunology
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