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International Archives of Allergy and Immunology

Alexander V Karaulov, Tamara Vylegzhanina, Andrey Ovchinnikov, Mariia Chernikova, Nataiya Nenasheva
BACKGROUND: Intranasal sprays are recommended as targeted therapy for allergic rhinitis (AR). Triamcinolone acetonide is a nasal corticosteroid preparation indicated for the treatment of seasonal and perennial AR (PAR) in different countries worldwide. OBJECTIVES: In order to determine the efficacy of triamcinolone acetonide in the treatment of PAR, the non-inferiority of triamcinolone acetonide to fluticasone propionate was assessed in Russian adults. METHODS: In this randomized, double-blind, parallel-group, multicenter, prospective, non-inferiority, phase III clinical trial, a total of 260 patients with persistent PAR were randomized to receive either triamcinolone acetonide or fluticasone propionate nasal sprays for 4 weeks...
March 15, 2019: International Archives of Allergy and Immunology
Eric Tyrell Oliver, Kris Chichester, Kelly Devine, Patricia Meghan Sterba, Craig Wegner, Becky Marie Vonakis, Sarbjit Singh Saini
BACKGROUND: Approximately 50% of patients with chronic spontaneous urticaria (CSU) experience symptoms that are not fully controlled by antihistamines, indicating an unmet clinical need. OBJECTIVE: To evaluate the effects of the selective CRTh2 antagonist AZD1981 on symptoms and targeted leukocytes in adults with persistent CSU despite treatment with H1-antihistamines. METHODS: We performed a single-center, randomized, placebo-controlled study involving adult CSU subjects with symptoms despite daily antihistamines...
March 15, 2019: International Archives of Allergy and Immunology
Lin Hu, Ling Mao, Shiming Liu, Juanjuan Zhao, Chao Chen, Mengmeng Guo, Zhixu He, Jie Yang, Wei Xu, Lin Xu
MicroRNAs (miRNAs) are a class of endogenous noncoding single-stranded RNAs widely distributed in eukaryotes, which can modulate target gene expression at posttranscriptional level and participate in cell proliferation, differentiation, and apoptosis. Related studies have shown that mi-RNAs are instrumental to many aspects of immunity, including various levels of T-cell immunity. In addition, multiple miRNAs have been ascribed key roles in T-cell development, differentiation, and function. In this review, we highlight the current literature regarding the functional role of miRNAs at various stages of thymocyte development...
March 12, 2019: International Archives of Allergy and Immunology
Sandra Louise Brandi, Lars K Poulsen, Lene Heise Garvey
BACKGROUND: In pollen-allergic patients, cross-reacting allergens including cross-reactive carbohydrate determinants (CCDs) and profilins may result in positive natural rubber latex (NRL)-specific IgE (sIgE) antibody tests but the relationship between this sensitization and clinical NRL type 1 allergy is poorly described. OBJECTIVE: The aims of this study were to determine the frequency and clinical relevance of NRL sIgE in grass pollen-sensitized individuals and to investigate which NRL allergen components these individuals were sensitized to...
March 8, 2019: International Archives of Allergy and Immunology
Kosuke Akiyama, Seiichiro Makihara, Kensuke Uraguchi, Yasushi Samukawa, Aiko Oka, Hiroshi Hoshikawa
BACKGROUND: The histological changes corticosteroids induce in nasal polyps, and whether these changes have an impact on the diagnosis of eosinophilic chronic rhinosinusitis (ECRS), currently remain unclear. OBJECTIVES: A prospective controlled multicenter trial was conducted to evaluate the efficacy of the low-dose and short-term oral prednisolone (oPSL) treatment for tissue eosinophil infiltrations in ECRS. METHODS: Subjects with ECRS diagnosed by previous biopsies received a low dose of oPSL for 3 days (PSL 3) or 7 days (PSL 7) before surgery...
February 22, 2019: International Archives of Allergy and Immunology
Juan Peng, Xiao-Ming Li, Guo-Rui Zhang, Yi Cheng, Xi Chen, Wen Gu, Xue-Jun Guo
BACKGROUND: TNF-TNFR2 signaling has been indicated to be involved in CD4+ T lymphocyte differentiation. However, its role in allergic airway inflammation is not well understood. OBJECTIVES: The aim of this study was to investigate the role of TNF-TNFR2 signaling in allergic airway inflammation. METHODS AND RESULTS: In this study, we used an allergen-induced asthma model to show that TNF-TNFR2 signaling alleviated allergic airway inflammation by reducing the airway infiltration of eosinophils and neutrophils...
February 14, 2019: International Archives of Allergy and Immunology
Tae-Hyung Kim, Soon Ho Yoon, Hyunsook Hong, Hye-Ryun Kang, Sang-Heon Cho, Suh-Young Lee
BACKGROUND: We conducted a meta-analysis to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction. METHODS: A systematic literature search identified studies on adult patients with anaphylaxis and a subsequent biphasic reaction due to various causes that contained sufficient data to extract outcomes. The outcomes were pooled using a random-effects model. RESULTS: Twelve studies with a total of 2,890 adult patients with anaphylaxis and 143 patients with a biphasic reaction were included...
February 14, 2019: International Archives of Allergy and Immunology
Igor Kaidashev, Halyna Morokhovets, Viktoriia Rodinkova, Jean Bousquet
BACKGROUND: Google Trends (GT) may represent a new approach to assessing pollen allergy. However, the development of a pan-European sentinel network has raised a problem of translating terms in different languages. A precise definition of the pollen season onset is crucial for the confirmation of a pollen allergy diagnosis and personalized treatment. Ragweed pollen allergy was investigated due to its high allergenicity and wide expansion in Europe. OBJECTIVES: The study aimed to examine translations of "ragweed" and "hay fever" in native Cyrillic languages, especially in Ukrainian and Russian, and to compare the seasonality of queries in Ukraine with ragweed and mugwort pollen counts...
February 13, 2019: International Archives of Allergy and Immunology
Tetsuya Homma, Tomoko Kawahara, Hatsuko Mikuni, Tomoki Uno, Haruna Sato, Akiko Fujiwara, Yoshitaka Uchida, Yosuke Fukuda, Ryo Manabe, Hitomi Ida, Naota Kuwahara, Tomoyuki Kimura, Kuniaki Hirai, Yoshito Miyata, Megumi Jinno, Munehiro Yamaguchi, Yasunari Kishino, Yasunori Murata, Shin Ohta, Mayumi Yamamoto, Yoshio Watanabe, Hirofumi Yamaguchi, Sojiro Kusumoto, Shintaro Suzuki, Akihiko Tanaka, Takuya Yokoe, Tsukasa Ohnishi, Hironori Sagara
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and asthma have similar clinical features and are both exacerbated by airway infection. OBJECTIVE: To determine whether garenoxacin mesylate hydrate (GRNX) added to the standard care for bacterial infection-induced acute exacerbation of asthma or COPD in adults has clinical benefits. METHOD: This single-arm clinical trial was conducted from January 2015 to March 2016. Adults with a history of asthma or COPD for more than 12 months were recruited within 48 h of presentation with fever and acute deterioration of asthma or COPD requiring additional intervention...
February 13, 2019: International Archives of Allergy and Immunology
Louise Heydenreich Jensen, Jeppe Madura Larsen, Charlotte Bernhard Madsen, Rune Rønhave Laursen, Lotte Neergaard Jacobsen, Katrine Lindholm Bøgh
BACKGROUND: Infant formulas (IFs) based on hydrolysed cow's milk proteins are central in the management of cow's milk allergy (CMA) in infants and small children. New IF compositions with improved prevention and treatment properties are needed, along with appropriate preclinical animal models, to evaluate these properties before introduction into humans. OBJECTIVES: We aimed to develop preclinical models for the assessment of the primary preventive and desensitising capacity of cow's milk IF in allergy-prone, high-IgE responder Brown Norway rats...
February 13, 2019: International Archives of Allergy and Immunology
Bandar Al-Saud, Sigurveig T Sigurdardóttir
No abstract text is available yet for this article.
February 8, 2019: International Archives of Allergy and Immunology
Dagmar Simon, Andreas Wollenberg, Harald Renz, Hans-Uwe Simon
Atopic dermatitis (AD) is a chronic inflammatory skin disease presenting with recurrent eczematous lesions and intense pruritus. It is common and affects both children and adults, often beginning in infancy. Due to the unpredictable disease course, its visible skin lesions, itching and scratching followed by sleeplessness, other associated atopic diseases, and behavioral and psychiatric disorders, AD is an immense burden for patients and caregivers. AD is determined by a genetic predisposition characterized by an impaired skin barrier and a T-helper-2-predominant inflammation...
February 8, 2019: International Archives of Allergy and Immunology
Simona Di Mario, Adriano Cattaneo
No abstract text is available yet for this article.
February 8, 2019: International Archives of Allergy and Immunology
Lauri J Moilanen, Mari Hämäläinen, Pinja Ilmarinen, Hannu Kankaanranta, Riina M Nieminen, Eeva Moilanen, Lauri Lehtimäki
BACKGROUND: Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and to be activated by reactive oxygen and nitrogen species (ROS and RNS) produced at the sites of inflammation. Because neurogenic inflammation as well as the release of ROS and RNS are typical features of early stages of allergic responses, we hypothesized that TRPA1 may be involved in triggering and/or amplifying allergic inflammation. OBJECTIVE: This study aims at exploring the role of TRPA1 ion channel in acute ovalbumin-induced allergic inflammation in applicable murine models...
January 30, 2019: International Archives of Allergy and Immunology
Gabriela Zambrano Ibarra, Victoria Fuentes Aparicio, Sonsoles Infante Herrero, Miguel Blanca, Lydia Zapatero Remon
BACKGROUND: Peanut storage proteins (Ara h 1, Ara h 2, and Ara h 3) have been described as the major peanut allergens in children, although not all peanut-sensitized individuals have clinical reactivity after exposure. OBJECTIVES: We studied the sensitization profile of peanut-allergic and peanut-tolerant children in a pediatric cohort. METHODS: The clinical features and sensitization profile to the peanut storage proteins Ara h 9 and Pru p 3 were compared between peanut-allergic and peanut-tolerant children using component-resolved diagnostics...
January 24, 2019: International Archives of Allergy and Immunology
Natalia I Ilyina, Anton S Edin, Natalia G Astafieva, Andrey S Lopatin, Irina V Sidorenko, Olga P Ukhanova, Fatimat M Khanova
BACKGROUND: The novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in a single spray (MP-AzeFlu) was compared with a first-line intranasal antihistamine spray (AZE) in Russian seasonal allergic rhinitis (SAR) patients. METHODS: Moderate-to-severe SAR/rhinoconjunctivitis patients (n = 149; aged 18-65 years) were randomized to receive MP-AzeFlu (137/50 μg AZE/FP per spray) or AZE (137 μg/spray), both as 1 spray/nostril twice daily, in a multicenter, open-label, 14-day, parallel-group trial...
January 24, 2019: International Archives of Allergy and Immunology
Yutaka Ueda, Kazuyuki Nakagome, Takehito Kobayashi, Toru Noguchi, Tomoyuki Soma, Katsuyo Ohashi-Doi, Kenichi Tokuyama, Makoto Nagata
BACKGROUND: Even in subjects who are not sensitized to house dust mite (HDM), allergic symptoms can be aggravated by exposure to dust, suggesting that innate immune responses may be involved in these processes. Since eosinophils express pattern recognition receptors, HDM may directly upregulate eosinophil functions through these re ceptors. The objective of this study was to examine whether Dermatophagoides farinae (Df), a representative HDM, or Der f 1, a major allergen of Df, modifies the effector functions of eosinophils...
January 10, 2019: International Archives of Allergy and Immunology
Bin Lou, Zhen Xu, Guangdie Yang, Chuangen Guo, Shufa Zheng, Haiyan Lou, Guanghua Ma, Annapurna Sadhukhan, Sha Lin, Yu Chen
INTRODUCTION: Allergic bronchopulmonary aspergillosis (ABPA) has been regarded as a rare disease in China due to the lack of quantitative detection of Aspergillus fumigatus-specific IgE (sIgE). We compared the diagnostic rate of ABPA among asthma patients with or without A. fumigatus-sIgE screening tests to evaluate the benefit of the tests in diagnosing ABPA. METHODS: We reviewed the detection rate of A. fumigatus-sIgE and the diagnostic rate of ABPA in 1842 asthma patients in the First Affiliated Hospital of Zhejiang University from 2014 to 2016...
January 9, 2019: International Archives of Allergy and Immunology
Alicia Armentia, Fernando Pineda, Sara Fernandez-Cortés, Angela Moro, Blanca Martin-Armentia, Paula Mendez, Ana Porcuna, Jorge Mendez-Alcalde
BACKGROUND: Mastocytosis involves the abnormal proliferation of mast cells and clinical variability. In the case of anaphylaxis, the triggering antigen, often associated with Hymenoptera allergens, must be identified. The common fig (Ficus carica) requires the fig wasp (Blastophaga psenes) for pollination. OBJECTIVE: We evaluated the ingestion of B. psenes as a trigger of anaphylaxis in patients with mastocytosis. MATERIAL AND METHODS: Skin prick tests (SPTs) and specific immunoglobulin E to the possible involved allergens were carried out in the patient and in 4 controls allergic to Hymenoptera and fig...
January 9, 2019: International Archives of Allergy and Immunology
Youjin Li, Xiaoqing Rui, Beiying Ma, Fan Jiang, Jie Chen
BACKGROUND: While early-life risk factors are known to influence the risk of allergies, the biological mechanisms underlying this observation are unclear. The aim of this study was to examine whether DNA methylation in childhood could underlie the association between early-life risk factors and allergic rhinitis (AR). METHODS: In total, 234 patients, aged 6 years, were recruited, i.e., 114 were patients with AR (AR group) and 120 healthy children without AR (NAR group)...
January 4, 2019: International Archives of Allergy and Immunology
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