journal
https://read.qxmd.com/read/37699855/the-functional-roles-of-protein-glycosylation-in-human-maternal-fetal-crosstalk
#1
JOURNAL ARTICLE
Jiangming Zhong, Jianlin Li, Graham J Burton, Hannu Koistinen, Ka Wang Cheung, Ernest H Y Ng, Yuanqing Yao, William S B Yeung, Cheuk-Lun Lee, Philip C N Chiu
BACKGROUND: The establishment of maternal-fetal crosstalk is vital to a successful pregnancy. Glycosylation is a post-translational modification in which glycans (monosaccharide chains) are attached to an organic molecule. Glycans are involved in many physiological and pathological processes. Human endometrial epithelium, endometrial gland secretions, decidual immune cells, and trophoblasts are highly enriched with glycoconjugates and glycan-binding molecules important for a healthy pregnancy...
September 12, 2023: Human Reproduction Update
https://read.qxmd.com/read/37697674/transcriptomic-integrity-of-human-oocytes-used-in-arts-technical-and-intrinsic-factor-effects
#2
JOURNAL ARTICLE
Bastien Ducreux, Catherine Patrat, Jacquetta Trasler, Patricia Fauque
BACKGROUND: Millions of children have been born throughout the world thanks to ARTs, the harmlessness of which has not yet been fully demonstrated. For years, efforts to evaluate the specific effects of ART have focused on the embryo; however, it is the oocyte quality that mainly dictates first and foremost the developmental potential of the future embryo. Ovarian stimulation, cryopreservation, and IVM are sometimes necessary steps to obtain a mature oocyte, but they could alter the appropriate expression of the oocyte genome...
September 11, 2023: Human Reproduction Update
https://read.qxmd.com/read/37639630/a-fresh-start-for-ivm-capacitating-the-oocyte-for-development-using-pre-ivm
#3
JOURNAL ARTICLE
Robert B Gilchrist, Tuong M Ho, Michel De Vos, Flor Sanchez, Sergio Romero, William L Ledger, Ellen Anckaert, Lan N Vuong, Johan Smitz
BACKGROUND: While oocyte IVM is practiced sporadically it has not achieved widespread clinical practice globally. However, recently there have been some seminal advances in our understanding of basic aspects of oocyte biology and ovulation from animal studies that have led to novel approaches to IVM. A significant recent advance in IVM technology is the use of biphasic IVM approaches. These involve the collection of immature oocytes from small antral follicles from minimally stimulated patients/animals (without hCG-priming) and an ∼24 h pre-culture of oocytes in an advanced culture system ('pre-IVM') prior to IVM, followed by routine IVF procedures...
August 28, 2023: Human Reproduction Update
https://read.qxmd.com/read/37507148/artificial-cycle-frozen-embryo-transfer-and-obstetric-adverse-outcomes-association-or-causation
#4
EDITORIAL
Andrea Busnelli, Nicoletta Di Simone, Paolo Emanuele Levi-Setti
No abstract text is available yet for this article.
July 28, 2023: Human Reproduction Update
https://read.qxmd.com/read/37507139/reply-artificial-cycle-frozen-embryo-transfer-and-obstetric-adverse-outcomes-association-or-causation
#5
EDITORIAL
T R Zaat, F Mol, M van Wely
No abstract text is available yet for this article.
July 28, 2023: Human Reproduction Update
https://read.qxmd.com/read/37468438/endometrial-receptivity-in-women-of-advanced-age-an-underrated-factor-in-infertility
#6
JOURNAL ARTICLE
Amruta D S Pathare, Marina Loid, Merli Saare, Sebastian Brusell Gidlöf, Masoud Zamani Esteki, Ganesh Acharya, Maire Peters, Andres Salumets
BACKGROUND: Modern lifestyle has led to an increase in the age at conception. Advanced age is one of the critical risk factors for female-related infertility. It is well known that maternal age positively correlates with the deterioration of oocyte quality and chromosomal abnormalities in oocytes and embryos. The effect of age on endometrial function may be an equally important factor influencing implantation rate, pregnancy rate, and overall female fertility. However, there are only a few published studies on this topic, suggesting that this area has been under-explored...
July 19, 2023: Human Reproduction Update
https://read.qxmd.com/read/37467045/assessing-the-influence-of-preconception-diet-on-female-fertility-a-systematic-scoping-review-of-observational-studies
#7
JOURNAL ARTICLE
Simon Alesi, Nahal Habibi, Thais Rasia Silva, Nicole Cheung, Sophia Torkel, Chau Thien Tay, Alejandra Quinteros, Hugo Winter, Helena Teede, Aya Mousa, Jessica A Grieger, Lisa J Moran
BACKGROUND: Preconception diet is a proposed modifiable risk factor for infertility. However, there is no official guidance for women in the preconception period as to which dietary approaches may improve fertility. OBJECTIVE AND RATIONALE: A comprehensive synthesis of the relevant evidence is key to determine the potentially effective dietary patterns and components as well as evidence gaps, and to provide information for nutritional recommendations for couples planning a pregnancy...
July 19, 2023: Human Reproduction Update
https://read.qxmd.com/read/37667981/is-it-new-is-it-true-and-do-we-care-the-role-of-prospective-review-registration
#8
JOURNAL ARTICLE
Madelon van Wely, Julie M Hastings, Basil Tarlatzis, Arne Sunde
No abstract text is available yet for this article.
September 5, 2023: Human Reproduction Update
https://read.qxmd.com/read/37290428/endometrial-responses-to-bacterial-and-viral-infection-a-scoping-review
#9
REVIEW
Christina V Lindsay, Julie A Potter, Alyssa A Grimshaw, Vikki M Abrahams, Mancy Tong
BACKGROUND: The endometrium is a highly dynamic tissue that undergoes dramatic proliferation and differentiation monthly in order to prepare the uterus for implantation and pregnancy. Intrauterine infection and inflammation are being increasingly recognized as potential causes of implantation failure and miscarriage, as well as obstetric complications later in gestation. However, the mechanisms by which the cells of the endometrium respond to infection remain understudied and recent progress is slowed in part owing to similar overlapping studies being performed in different species...
September 5, 2023: Human Reproduction Update
https://read.qxmd.com/read/36977357/total-fertilization-failure-after-icsi-insights-into-pathophysiology-diagnosis-and-management-through-artificial-oocyte-activation
#10
REVIEW
Gerard Campos, Romualdo Sciorio, Sandro C Esteves
BACKGROUND: Total fertilization failure (TFF) is the failure of all metaphase II oocytes to fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1-3% of ICSI cycles. Oocyte activation deficiency (OAD) is the leading cause of fertilization failure, attributed to sperm- or oocyte-related issues, although until recently little attention has been given to oocyte-related deficiencies. Different strategies for overcoming TFF have been proposed in clinical settings, mainly using artificial oocyte activation (AOA) by calcium ionophores...
July 5, 2023: Human Reproduction Update
https://read.qxmd.com/read/36882116/contribution-of-semen-to-early-embryo-development-fertilization-and-beyond
#11
REVIEW
Montserrat Vallet-Buisan, Rajwa Mecca, Celine Jones, Kevin Coward, Marc Yeste
BACKGROUND: It has long been thought that the factors affecting embryo and foetal development were exclusively maternally derived; hence, if issues regarding fertility and embryo development were to arise, the blame has traditionally been placed solely on the mother. An escalating interest in how paternal factors influence embryo development, however, has begun to prove otherwise. Evidence suggests that both seminal plasma (SP) and sperm contribute multiple factors that shape embryogenesis...
July 5, 2023: Human Reproduction Update
https://read.qxmd.com/read/36857094/beyond-apoptosis-evidence-of-other-regulated-cell-death-pathways-in-the-ovary-throughout-development-and-life
#12
REVIEW
Jessica M Stringer, Lauren R Alesi, Amy L Winship, Karla J Hutt
BACKGROUND: Regulated cell death is a fundamental component of numerous physiological processes; spanning from organogenesis in utero, to normal cell turnover during adulthood, as well as the elimination of infected or damaged cells throughout life. Quality control through regulation of cell death pathways is particularly important in the germline, which is responsible for the generation of offspring. Women are born with their entire supply of germ cells, housed in functional units known as follicles...
July 5, 2023: Human Reproduction Update
https://read.qxmd.com/read/37353909/the-pathophysiological-role-of-estrogens-in-the-initial-stages-of-pregnancy-molecular-mechanisms-and-clinical-implications-for-pregnancy-outcome-from-the-periconceptional-period-to-end-of-the-first-trimester
#13
JOURNAL ARTICLE
F Parisi, C Fenizia, A Introini, A Zavatta, C Scaccabarozzi, M Biasin, V Savasi
BACKGROUND: Estrogens regulate disparate female physiological processes, thus ensuring reproduction. Altered estrogen levels and signaling have been associated with increased risks of pregnancy failure and complications, including hypertensive disorders and low birthweight babies. However, the role of estrogens in the periconceptional period and early pregnancy is still understudied. OBJECTIVE AND RATIONALE: This review aims to summarize the current evidence on the role of maternal estrogens during the periconceptional period and the first trimester of pregnancies conceived naturally and following ART...
June 23, 2023: Human Reproduction Update
https://read.qxmd.com/read/37353908/pcos-during-the-menopausal-transition-and-after-menopause-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Mercedes Millán-de-Meer, Manuel Luque-Ramírez, Lía Nattero-Chávez, Héctor F Escobar-Morreale
BACKGROUND: Current knowledge about the consequences of PCOS during the late reproductive years and after menopause is limited. OBJECTIVE AND RATIONALE: We performed a systematic review and meta-analysis of data on the pathophysiology, clinical manifestations, diagnosis, prognosis, and treatment of women ≥45 years of age-peri- or postmenopausal-with PCOS. SEARCH METHODS: Studies published up to 15 April 2023, identified by Entrez-PubMed, EMBASE, and Scopus online facilities, were considered...
June 23, 2023: Human Reproduction Update
https://read.qxmd.com/read/37353907/dissecting-mammalian-reproduction-with-spatial-transcriptomics
#15
JOURNAL ARTICLE
Xin Zhang, Qiqi Cao, Shreya Rajachandran, Edward J Grow, Melanie Evans, Haiqi Chen
BACKGROUND: Mammalian reproduction requires the fusion of two specialized cells: an oocyte and a sperm. In addition to producing gametes, the reproductive system also provides the environment for the appropriate development of the embryo. Deciphering the reproductive system requires understanding the functions of each cell type and cell-cell interactions. Recent single-cell omics technologies have provided insights into the gene regulatory network in discrete cellular populations of both the male and female reproductive systems...
June 23, 2023: Human Reproduction Update
https://read.qxmd.com/read/37336552/endometrial-scratching-in-women-undergoing-ivf-icsi-an-individual-participant-data-meta-analysis
#16
JOURNAL ARTICLE
Nienke E van Hoogenhuijze, Gemma Lahoz Casarramona, Sarah Lensen, Cindy Farquhar, Mohan S Kamath, Aleyamma T Kunjummen, Nick Raine-Fenning, Sine Berntsen, Anja Pinborg, Shari Mackens, Zeynep Ozturk Inal, Ernest H Y Ng, Jennifer S M Mak, Sachin A Narvekar, Wellington P Martins, Mia Steengaard Olesen, Helen L Torrance, Ben W Mol, Marinus J C Eijkemans, Rui Wang, Frank J M Broekmans
BACKGROUND: In IVF/ICSI treatment, the process of embryo implantation is the success rate-limiting step. Endometrial scratching has been suggested to improve this process, but it is unclear if this procedure increases the chance of implantation and live birth (LB) and, if so, for whom, and how the scratch should be performed. OBJECTIVE AND RATIONALE: This individual participant data meta-analysis (IPD-MA) aims to answer the question of whether endometrial scratching in women undergoing IVF/ICSI influences the chance of a LB, and whether this effect is different in specific subgroups of women...
June 19, 2023: Human Reproduction Update
https://read.qxmd.com/read/37328434/uterus-transplantation-from-research-through-human-trials-and-into-the-future
#17
JOURNAL ARTICLE
Mats Brännström, Catherine Racowsky, Marie Carbonnel, Joseph Wu, Antonio Gargiulo, Eli Y Adashi, Jean Marc Ayoubi
Women suffering from absolute uterine factor infertility (AUFI) had no hope of childbearing until clinical feasibility of uterus transplantation (UTx) was documented in 2014 with the birth of a healthy baby. This landmark accomplishment followed extensive foundational work with a wide range of animal species including higher primates. In the present review, we provide a summary of the animal research and describe the results of cases and clinical trials on UTx. Surgical advances for graft removal from live donors and transplantation to recipients are improving, with a recent trend away from laparotomy to robotic approaches, although challenges persist regarding optimum immunosuppressive therapies and tests for graft rejection...
June 16, 2023: Human Reproduction Update
https://read.qxmd.com/read/37192834/opening-the-black-box-why-do-euploid-blastocysts-fail-to-implant-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Danilo Cimadomo, Laura Rienzi, Alessandro Conforti, Eric Forman, Stefano Canosa, Federica Innocenti, Maurizio Poli, Jenna Hynes, Laura Gemmell, Alberto Vaiarelli, Carlo Alviggi, Filippo Maria Ubaldi, Antonio Capalbo
BACKGROUND: A normal chromosomal constitution defined through PGT-A assessing all chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo implantation. Yet, its positive predictive value is not higher than 50-60%. This gap of knowledge on the causes of euploid blastocysts' reproductive failure is known as 'the black box of implantation'. OBJECTIVE AND RATIONALE: Several embryonic, maternal, paternal, clinical, and IVF laboratory features were scrutinized for their putative association with reproductive success or implantation failure of euploid blastocysts...
May 16, 2023: Human Reproduction Update
https://read.qxmd.com/read/37172270/obstetric-and-neonatal-outcomes-after-natural-versus-artificial-cycle-frozen-embryo-transfer-and-the-role-of-luteal-phase-support-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
T R Zaat, E B Kostova, P Korsen, M G Showell, F Mol, M van Wely
BACKGROUND: The number of frozen embryo transfers (FET) has increased dramatically over the past decade. Based on current evidence, there is no difference in pregnancy rates when natural cycle FET (NC-FET) is compared to artificial cycle FET (AC-FET) in subfertile women. However, NC-FET seems to be associated with lower risk of adverse obstetric and neonatal outcomes compared with AC-FET cycles. Currently, there is no consensus about whether NC-FET needs to be combined with luteal phase support (LPS) or not...
May 12, 2023: Human Reproduction Update
https://read.qxmd.com/read/37159502/insights-from-mendelian-randomization-and-genetic-correlation-analyses-into-the-relationship-between-endometriosis-and-its-comorbidities
#20
JOURNAL ARTICLE
Isabelle M McGrath, Grant W Montgomery, Sally Mortlock
BACKGROUND: Endometriosis remains a poorly understood disease, despite its high prevalence and debilitating symptoms. The overlap in symptoms and the increased risk of multiple other traits in women with endometriosis is becoming increasingly apparent through epidemiological data. Genetic studies offer a method of investigating these comorbid relationships through the assessment of causal relationships with Mendelian randomization (MR), as well as identification of shared genetic variants and genes involved across traits...
May 9, 2023: Human Reproduction Update
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