journal
https://read.qxmd.com/read/38794915/the-impact-of-treatment-for-childhood-classical-hodgkin-lymphoma-according-to-the-euronet-phl-c2-protocol-on-serum-anti-m%C3%A3-llerian-hormone
#1
JOURNAL ARTICLE
K C E Drechsel, S L Broer, F S Stoutjesdijk, E van Dulmen-den Broeder, A Beishuizen, W H Wallace, D Körholz, C Mauz-Körholz, D Hasenclever, M Cepelova, A Uyttebroeck, L Ronceray, J W R Twisk, G J L Kaspers, M A Veening
STUDY QUESTION: What is the impact of the EuroNet-PHL-C2 treatment protocol for children with classical Hodgkin lymphoma (cHL) on gonadal function in girls, based on assessment of serum anti-Müllerian hormone (AMH)? SUMMARY ANSWER: Serum AMH levels decreased after induction chemotherapy and increased during subsequent treatment and 2 years of follow-up, with lowest levels in patients treated for advanced stage cHL. WHAT IS KNOWN ALREADY: Treatment for cHL, particularly alkylating agents and pelvic irradiation, can be gonadotoxic and result in premature reduction of primordial follicles in females...
May 24, 2024: Human Reproduction
https://read.qxmd.com/read/38794911/fertility-preservation-before-cancer-treatment-the-dilemma-of-saying-no-as-the-price-of-glory
#2
JOURNAL ARTICLE
Michaël Grynberg, Nathalie Sermondade
A great deal of work has been carried out by professionals in reproductive medicine in order to raise awareness about fertility preservation (FP) techniques, particularly for women, and to ensure that FP is included in the care of young adults treated for cancer or a pathology requiring gonadotoxic treatment. If the importance of the development of our discipline is obvious, our militancy in favour of FP and our emotional projections must not make us forget that medical thinking must be carried out not only on a case-by-case basis, weighing up the benefit-risk balance, but also without losing sight that conceiving a child with one's own gametes is not a vital issue...
May 24, 2024: Human Reproduction
https://read.qxmd.com/read/38783613/protocol-change-improves-live-birth-and-recurrent-cycle-cancellation-rates-after-a-previous-ivf-cycle-cancellation-an-analysis-of-13%C3%A2-000-autologous-cycles-reported-to-sart-cors
#3
JOURNAL ARTICLE
J L Kahn, H Wu, R Gerber, T Shah, H Lieman, S E Pollack, M Singh, S Jindal
STUDY QUESTION: After an IVF cycle cancellation, does changing the stimulation protocol affect the odds of live birth and recurrent cancellation in the subsequent cycle? SUMMARY ANSWER: After IVF cycle cancellation, compared to those who repeated the same stimulation protocol, those who changed their protocol had higher odds of live birth and lower odds of recurrent cycle cancellation. WHAT IS KNOWN ALREADY: There is limited data addressing the effect of changing the stimulation protocol after an IVF cycle is cancelled during initial stimulation...
May 23, 2024: Human Reproduction
https://read.qxmd.com/read/38783610/excessive-proliferating-cell-nuclear-antigen-attenuates-endometrial-adhesive-capacity-and-decidualization-in-patients-with-recurrent-implantation-failure
#4
JOURNAL ARTICLE
Huishan Zhao, Mingwei Yu, Qian Li, Gang Chen, Xuemei Liu, Hongchu Bao
STUDY QUESTION: Does the expression of proliferating cell nuclear antigen (PCNA) in the endometrium regulate endometrial receptivity in patients with recurrent implantation failure (RIF)? SUMMARY ANSWER: A high abundance of PCNA attenuates endometrial adhesive capacity and decidualization in patients with RIF. WHAT IS KNOWN ALREADY: Aberrant expression of PCNA has been discovered in multiple infertility-related disorders. However, the expression pattern and role of PCNA in the establishment of endometrial receptivity and endometrial decidualization in patients with RIF remain unclear...
May 23, 2024: Human Reproduction
https://read.qxmd.com/read/38775335/monocytes-expressing-activin-a-and-ccr2-exacerbate-chronic-testicular-inflammation-by-promoting-immune-cell-infiltration
#5
JOURNAL ARTICLE
Hiba Hasan, Wei Peng, Rukmali Wijayarathna, Eva Wahle, Daniela Fietz, Sudhanshu Bhushan, Christiane Pleuger, Ana Planinić, Stefan Günther, Kate L Loveland, Adrian Pilatz, Davor Ježek, Hans-Christian Schuppe, Andreas Meinhardt, Mark P Hedger, Monika Fijak
STUDY QUESTION: Does the chemokine/chemokine receptor axis, involved in immune cell trafficking, contribute to the pathology of testicular inflammation and how does activin A modulate this network? SUMMARY ANSWER: Testicular chemokines and their receptors (especially those essential for trafficking of monocytes) are elevated in orchitis, and activin A modulates the expression of the chemokine/chemokine receptor network to promote monocyte/macrophage and T cell infiltration into the testes, causing extensive tissue damage...
May 22, 2024: Human Reproduction
https://read.qxmd.com/read/38775332/internal-and-external-adenomyosis-phenotypes-ultrasound-features-and-association-with-clinical-outcomes
#6
JOURNAL ARTICLE
M Valdés-Bango, C Ros, M Daza, M Rius, M Gracia, M Martínez-Zamora, C De Guirior, L Quintas, F Carmona
STUDY QUESTION: What are the sonographic and clinical findings in women diagnosed with external and internal adenomyosis by ultrasound? SUMMARY ANSWER: Patients with external and internal adenomyosis phenotypes, diagnosed by ultrasound, present differences in sonographic features of the disease and demographic characteristics including age, parity, and association with deep endometriosis (DE) and leiomyomas. WHAT IS KNOWN ALREADY: Two different phenotypes of adenomyosis have been described based on the anatomical location of adenomyotic lesions in the myometrium, suggesting that adenomyosis affecting the inner myometrium and that affecting the external myometrial layer may have distinct origins...
May 22, 2024: Human Reproduction
https://read.qxmd.com/read/38775331/is-biochemical-pregnancy-loss-associated-with-embryo-or-endometrium-a-retrospective-cohort-study-in-frozen-single-embryo-transfer-of-own-and-donated-oocytes
#7
JOURNAL ARTICLE
E Munoz, E Taboas, M Alvarez, E Gil, A Perez, S Portela, M Martinez-Chapela, E Saucedo, N Garrido
STUDY QUESTION: Does the use of preimplantation genetic testing for aneuploidies (PGT-A), personalized embryo transfer with endometrial receptivity assay (pET-ERA), or the use of donated oocytes modify the incidence of biochemical pregnancy loss (BPL) in frozen single embryo transfer (FSET)? SUMMARY ANSWER: Following FSET, BPL incidence does not differ between own and donated oocytes, and the use of PGT-A with euploid embryo transfer or pET-ERA results in a similar incidence of BPL compared to cycles without embryo or endometrial analysis...
May 22, 2024: Human Reproduction
https://read.qxmd.com/read/38775072/circadian-serum-progesterone-variations-on-the-day-of-frozen-embryo-transfer-in-a-modified-natural-cycle-protocol
#8
JOURNAL ARTICLE
S Loreti, C Roelens, F Aktoz, M Niero, N De Munck, H Tournaye, S Mackens, C Blockeel
STUDY QUESTION: Is there a circadian variation of serum progesterone (P) on the day of frozen embryo transfer (FET) in a modified natural cycle (mNC)? SUMMARY ANSWER: There is a statistically significant diurnal variation of serum P on the day of a FET in an mNC protocol. WHAT IS KNOWN ALREADY: In recent years, the proportion of FET cycles has increased dramatically. To further optimize pregnancy outcomes after FET, recent studies have focused on serum luteal P levels in both natural and artificially prepared FET cycles...
May 22, 2024: Human Reproduction
https://read.qxmd.com/read/38756099/the-role-of-regulatory-t-cells-in-the-development-of-endometriosis
#9
JOURNAL ARTICLE
Jure Knez, Borut Kovačič, Aleš Goropevšek
Endometriosis is a benign disease of the female reproductive tract, characterized by the process of chronic inflammation and alterations in immune response. It is estimated to affect 2-19% of women in the general population and is commonly associated with symptoms of chronic pelvic pain and infertility. Regulatory T cells (Treg) are a subpopulation of T lymphocytes that are potent suppressors of inflammatory immune response, essential in preventing destructive immunity in all tissues. In endometriosis, several studies have investigated the possible role of Treg cells in the development of the disease...
May 16, 2024: Human Reproduction
https://read.qxmd.com/read/38741235/does-the-new-definition-of-recurrent-implantation-failure-have-clinical-relevance
#10
JOURNAL ARTICLE
Ramazan Mercan
No abstract text is available yet for this article.
May 13, 2024: Human Reproduction
https://read.qxmd.com/read/38741233/tex13b-is-essential-for-metabolic-reprogramming-during-germ-cell-differentiation
#11
JOURNAL ARTICLE
Umesh Kumar, Digumarthi V S Sudhakar, Nithyapriya Kumar, Anurupa Moitra, Hanuman T Kale, Rajan Kumar Jha, Shivali Rawat, Geetika Verma, Nalini J Gupta, Mamata Deenadayal, Aarti Deenadayal Tolani, Swasti Raychaudhuri, P Chandra Shekar, Kumarasamy Thangaraj
STUDY QUESTION: What is the functional significance of Tex13b in male germ cell development and differentiation? SUMMARY ANSWER: Tex13b regulates male germ cell differentiation by metabolic reprogramming during spermatogenesis. WHAT IS KNOWN ALREADY: Studies in mice and humans suggest that TEX13B is a transcription factor and is exclusively expressed in germ cells. STUDY DESIGN, SIZE, DURATION: We sequenced the coding regions of TEX13B in 628 infertile men and 427 ethnically matched fertile control men...
May 13, 2024: Human Reproduction
https://read.qxmd.com/read/38741229/reply-consecutive-euploid-blastocyst-transfers-currently-represent-the-best-available-model-for-investigating-the-true-prevalence-of-recurrent-implantation-failure-rif-a-rare-pathology-at-best
#12
EDITORIAL
Baris Ata, Pavan Gill, Danilo Cimadomo, Filippo Maria Ubaldi, Juan A Garcia-Velasco, Emre Seli
No abstract text is available yet for this article.
May 13, 2024: Human Reproduction
https://read.qxmd.com/read/38734930/rapamycin-prevents-cyclophosphamide-induced-ovarian-follicular-loss-and-potentially-inhibits-tumour-proliferation-in-a-breast-cancer-xenograft-mouse-model
#13
JOURNAL ARTICLE
Yuji Tanaka, Tsukuru Amano, Akiko Nakamura, Fumi Yoshino, Akie Takebayashi, Akimasa Takahashi, Hiroyuki Yamanaka, Ayako Inatomi, Tetsuro Hanada, Yutaka Yoneoka, Shunichiro Tsuji, Takashi Murakami
STUDY QUESTION: To what extent and via what mechanism does the concomitant administration of rapamycin (a follicle activation pathway inhibitor and antitumour agent) and cyclophosphamide (a highly toxic ovarian anticancer agent) prevent cyclophosphamide-induced ovarian reserve loss and inhibit tumour proliferation in a breast cancer xenograft mouse model? SUMMARY ANSWER: Daily concomitant administration of rapamycin and a cyclic regimen of cyclophosphamide, which has sufficient antitumour effects as a single agent, suppressed cyclophosphamide-induced primordial follicle loss by inhibiting primordial follicle activation in a breast cancer xenograft mouse model, suggesting the potential of an additive inhibitory effect against tumour proliferation...
May 11, 2024: Human Reproduction
https://read.qxmd.com/read/38734928/association-between-the-length-of-in-vitro-embryo-culture-mode-of-art-and-the-initial-endogenous-hcg-rise-in-ongoing-singleton-pregnancies
#14
JOURNAL ARTICLE
C Brockmeier, M B Borgstrøm, K Madsen, A Pinborg, N L Freiesleben, A Zedeler, M R Petersen, M L Grøndahl, P F Svendsen
STUDY QUESTION: Is there an association between the length of in vitro culture, mode of ART and the initial endogenous hCG rise, in cycles with a foetal heartbeat after single embryo transfer (ET) and implantation? SUMMARY ANSWER: Both the length of in vitro culture and the mode of ART have an impact on the initial endogenous rise in hCG in singleton pregnancies. WHAT IS KNOWN ALREADY: Different factors have been identified to alter the kinetics of hCG in pregnancies...
May 11, 2024: Human Reproduction
https://read.qxmd.com/read/38733103/reply-adolescent-girls-at-risk-of-polycystic-ovary-syndrome-in-east-asia
#15
EDITORIAL
Jin Ju Kim, Kyu Ri Hwang
No abstract text is available yet for this article.
May 10, 2024: Human Reproduction
https://read.qxmd.com/read/38733102/m%C3%A3-llerian-anomalies-and-endometriosis-as-potential-explanatory-models-for-the-retrograde-menstruation-implantation-and-the-embryonic-remnants-celomic-metaplasia-pathogenic-theories-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Paolo Vercellini, Noemi Salmeri, Edgardo Somigliana, Martina Piccini, Francesca Caprara, Paola Viganò, Sara De Matteis
STUDY QUESTION: Does endometriosis prevalence differ in patients with obstructive Müllerian anomalies (OMA) versus those with nonobstructive Müllerian anomalies (NOMA), and in patients with NOMA versus those without Müllerian anomalies? SUMMARY ANSWER: The quantitative synthesis of published data demonstrates a substantially increased prevalence of endometriosis in patients with OMA compared with those with NOMA, and a similar prevalence in patients with NOMA and those without Müllerian anomalies...
May 10, 2024: Human Reproduction
https://read.qxmd.com/read/38733101/correction-to-external-validation-of-models-for-predicting-cumulative-live-birth-over-multiple-complete-cycles-of-ivf-treatment
#17
(no author information available yet)
No abstract text is available yet for this article.
May 10, 2024: Human Reproduction
https://read.qxmd.com/read/38733100/placental-structural-adaptation-to-maternal-physical-activity-and-sedentary-behavior-findings-of-the-dali-lifestyle-study
#18
JOURNAL ARTICLE
Saghi Zafaranieh, Monika Siwetz, Barbara Leopold-Posch, Daniel Kummer, Berthold Huppertz, Gernot Desoye, Mireille van Poppel
STUDY QUESTION: Are maternal levels of moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) in obese pregnant women associated with placental structural adaptations for facilitating oxygen delivery to the fetus? SUMMARY ANSWER: Higher maternal MVPA and ST are associated with a higher density of villi, a proxy measure of placental surface area for oxygen delivery to the fetus, without further added placental vessels. WHAT IS KNOWN ALREADY: Physical activity during pregnancy intermittently reduces uterine blood flow, potentially limiting placental and fetal oxygen supply...
May 10, 2024: Human Reproduction
https://read.qxmd.com/read/38733097/adolescent-girls-at-risk-of-polycystic-ovary-syndrome-in-east-asia
#19
JOURNAL ARTICLE
Francis de Zegher, Lourdes Ibáñez
No abstract text is available yet for this article.
May 10, 2024: Human Reproduction
https://read.qxmd.com/read/38725195/palmitic-acid-impairs-human-and-mouse-placental-function-by-inhibiting-trophoblast-autophagy-through-induction-of-acyl-coenzyme-a-binding-protein-acbp-upregulation
#20
JOURNAL ARTICLE
Yi Zhang, Ling-Ling Ruan, Ming-Rui Li, Lu Yao, Fang-Fang Li, You-Long Xie, Jing Tang, Qian Feng, Xiao-Yan Chen, Yu-Bin Ding, Li-Juan Fu
STUDY QUESTION: Can exposure to palmitic acid (PA), a common saturated fatty acid, modulate autophagy in both human and mouse trophoblast cells through the regulation of acyl-coenzyme A-binding protein (ACBP)? SUMMARY ANSWER: PA exposure before and during pregnancy impairs placental development through mechanisms involving placental autophagy and ACBP expression. WHAT IS KNOWN ALREADY: High-fat diets, including PA, have been implicated in adverse effects on human placental and fetal development...
May 9, 2024: Human Reproduction
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