Yan Yi, Jing Fu, Shi Xie, Qiong Zhang, Bin Xu, Yonggang Wang, Yijing Wang, Bin Li, Guihu Zhao, Jinchen Li, Yanping Li, Jing Zhao
STUDY QUESTION: Can potential mechanisms involved in the likely concurrence of diminished ovarian reserve (DOR) and miscarriage be identified using genetic data? SUMMARY ANSWER: Concurrence between ovarian reserve and spontaneous miscarriage was observed, and may be attributed to shared genetic risk loci enriched in antigen processing and presentation and autoimmune disease pathways. WHAT IS KNOWN ALREADY: Previous studies have shown that lower serum anti-Müllerian hormone (AMH) levels are associated with increased risk of embryo aneuploidy and spontaneous miscarriage, although findings have not been consistent across all studies...
September 15, 2023: Human Reproduction
Nathalie Søderhamn Bülow, Agnieszka Katarzyna Warzecha, Mette Villads Nielsen, Claus Yding Andersen, Marianne Dreyer Holt, Morten Rønn Petersen, Negjyp Sopa, Anne Zedeler, Anne Lis Englund, Anja Pinborg, Marie Louise Grøndahl, Sven Olaf Skouby, Nicholas Stephen Macklon
STUDY QUESTION: Does letrozole (LZ) co-treatment during ovarian stimulation with gonadotropins for in IVF impact follicle recruitment, oocyte number and quality, embryo quality, or live birth rate (LBR)? SUMMARY ANSWER: No impact of LZ was found in follicle recruitment, number of oocytes, quality of embryos, or LBR. WHAT IS KNOWN ALREADY: Multi-follicle stimulation for IVF produces supra-physiological oestradiol levels. LZ is an aromatase inhibitor that lowers serum oestradiol thus reducing negative feedback and increasing the endogenous gonadotropins in both the follicular and the luteal phases, effectively normalizing the endocrine milieu during IVF treatment...
September 12, 2023: Human Reproduction
Audrey S Koh, Henny M W Bos, Esther D Rothblum, Nicola Carone, Nanette K Gartrell
STUDY QUESTION: How do adult offspring in planned lesbian-parent families feel about and relate to their donor (half) sibling(s) (DS)? SUMMARY ANSWER: A majority of offspring had found DS and maintained good ongoing relationships, and all offspring (regardless of whether a DS had been identified) were satisfied with their knowledge of and contact level with the DS. WHAT IS KNOWN ALREADY: The first generation of donor insemination offspring of intended lesbian-parent families is now in their 30s...
September 11, 2023: Human Reproduction
Álvaro Martínez-Moro, Leopoldo González-Brusi, Ana Querejeta-Fernández, Ester Padilla-Ruiz, Javier García-Blanco, Pablo Bermejo-Álvarez
STUDY QUESTION: Is the abundance of certain biochemical compounds in human cumulus cells (CCs) related to oocyte quality? SUMMARY ANSWER: Malonate, 5-oxyproline, and erythronate were positively associated with pregnancy potential. WHAT IS KNOWN ALREADY: CCs are removed and discarded prior to ICSI, thereby constituting an interesting biological material on which to perform molecular analysis aimed to predict oocyte developmental competence...
September 11, 2023: Human Reproduction
Zachary Walker, John Ernandez, Andrea Lanes, Serene S Srouji, Elizabeth Ginsburg, Martin Kathrins
STUDY QUESTION: What are the effects of male anxiety and depression on IVF outcomes? SUMMARY ANSWER: Men with anxiety had lower final total motile sperm counts (fTMSC) during IVF compared to men without anxiety; however, there were no differences in live birth rates (LBRs). WHAT IS KNOWN ALREADY: Studies have shown that male anxiety causes low sperm motility, worse sperm morphology, and increased DNA fragmentation, which are known to be influential factors on fertilization rates and embryo quality during IVF...
September 10, 2023: Human Reproduction
Aurélie Feraille, Agnès Liard, Nathalie Rives, Michael Bubenheim, Anne-Laure Barbotin, Sandrine Giscard d'Estaing, Sophie Mirallié, Amélie Ancelle, Christophe Roux, Florence Brugnon, Myriam Daudin, Pascale Schneider, Ludovic Dumont, Christine Rondanino
STUDY QUESTION: What is the impact of low- or moderate-risk gonadotoxic chemotherapy received prior to testicular tissue freezing (TTF), and of the cancer itself, on spermatogonia quantity in testicular tissue from (pre)pubertal boys? SUMMARY ANSWER: Vincristine, when associated with alkylating agents, has an additional adverse effect on spermatogonia quantity, while carboplatin has no individual contribution to spermatogonia quantity, in testicular tissue of (pre)pubertal boys, when compared to patients who have received non-alkylating chemotherapy...
September 7, 2023: Human Reproduction
Qin Li, Cuishan Chen, Jiaming Wu, Liona C Poon, Chi Chiu Wang, Tin Chiu Li, Tao Zhang, Xianghao Guo, Liang Song, Xia Wang, Qian Zhang, Ziying Ye, Yongkang Yang, Jing Lu, Jianyu Yao, Dewei Ye, Yao Wang
STUDY QUESTION: Can maternal serum levels of soluble programmed cell death-1 (sPD-1) and its ligand (sPD-L1) serve as biomarkers for missed miscarriage (MM)? SUMMARY ANSWER: Serum sPD-L1 levels are significantly decreased in MM patients and may serve as a potential predictive biomarker for miscarriage. WHAT IS KNOWN ALREADY: Programmed cell death-1 (PD-1) and its ligand (PD-L1) comprise important immune inhibitory checkpoint signaling to maintain pregnancy...
September 6, 2023: Human Reproduction
Myrthe A J Smits, Bauke V Schomakers, Michel van Weeghel, Eric J M Wever, Rob C I Wüst, Frederike Dijk, Georges E Janssens, Mariëtte Goddijn, Sebastiaan Mastenbroek, Riekelt H Houtkooper, Geert Hamer
STUDY QUESTION: Are human ovarian aging and the age-related female fertility decline caused by oxidative stress and mitochondrial dysfunction in oocytes? SUMMARY ANSWER: We found oxidative damage in oocytes of advanced maternal age, even at the primordial follicle stage, and confirmed mitochondrial dysfunction in such oocytes, which likely resulted in the use of alternative energy sources. WHAT IS KNOWN ALREADY: Signs of reactive oxygen species-induced damage and mitochondrial dysfunction have been observed in maturing follicles, and even in early stages of embryogenesis...
September 6, 2023: Human Reproduction
Gaojie Fan, Qing Liu, Jianing Bi, Xiya Qin, Qing Fang, Youjie Wang, Lulu Song
STUDY QUESTION: What are the associations between female-specific reproductive factors and leukocyte telomere length (LTL)? SUMMARY ANSWER: Early menarche, early menopause, short reproductive lifespan, early age at first birth, multiparity, and use of oral contraceptives (OCs) and hormone replacement therapy (HRT) were associated with shorter LTL. WHAT IS KNOWN ALREADY: Reproductive factors have been associated with age-related diseases, but their associations with cellular aging, as indicated by LTL, are unclear...
September 6, 2023: Human Reproduction
Viviana Chiappetta, Federica Innocenti, Giovanni Coticchio, Aisling Ahlström, Laura Albricci, Vicente Badajoz, Maria Hebles, Miguel Gallardo, Francesca Benini, Stefano Canosa, Jiří Kumpošt, Katarina Milton, Diletta Montanino Oliva, Roberta Maggiulli, Laura Rienzi, Danilo Cimadomo
STUDY QUESTION: Do embryologists from different European countries agree on embryo disposition decisions ('use' or 'discard') about Day 7 (>144 h post-insemination) and/or low-quality blastocysts (LQB; <Gardner's BB) (i.e. borderline quality blastocysts)? SUMMARY ANSWER: The prevalence of 'discard' answers was 38.7%; nevertheless, embryologists' agreement was overall just fair (Fleiss-k = 0.26). WHAT IS KNOWN ALREADY: The utilization of LQBs and adoption of culture beyond 144 h post-insemination is increasing worldwide...
August 30, 2023: Human Reproduction
Max H J M Curfs, Ben J Cohlen, Els J Slappendel, Dick C Schoot, Josien G Derhaag, Ron J T van Golde, Godfried W van der Heijden, Esther B Baart, Jesper M J Smeenk, Victoria E E G Ritfeld, Richard M Brohet, Casandra C A W van Bavel
STUDY QUESTION: Does assisted hatching increase the cumulative live birth rate in subfertile couples with repeated implantation failure? SUMMARY ANSWER: This study showed no evidence of effect for assisted hatching as an add-on in subfertile couples with repeated implantation failure. WHAT IS KNOWN ALREADY: The efficacy of assisted hatching, with regard to the live birth rate has not been convincingly demonstrated in randomized trials nor meta-analyses...
August 29, 2023: Human Reproduction
Erica M Lokken, Emmanuel Kabare, Brenda Oyaro, Maureen Nyaigero, John Kinuthia, Walter Jaoko, Kishor Mandaliya, R Scott McClelland, Lisa E Manhart
STUDY QUESTION: Is Mycoplasma genitalium-infection associated with reduced fecundability? SUMMARY ANSWER: Preconception M. genitalium-infection was associated with 27% lower fecundability though confidence intervals were wide, and the association between M. genitalium and fecundability may be dependent on concurrent bacterial vaginosis (BV). WHAT IS KNOWN ALREADY: M. genitalium has been associated with cervicitis, pelvic inflammatory disease, infertility, and preterm birth, but the extent to which M...
August 26, 2023: Human Reproduction
Clara Colombo, Nina Pistoljevic-Kristiansen, Marte Saupstad, Sara Johanna Bergenheim, Anne Lærke Spangmose, Anna Klajnbard, Nina la Cour Freiesleben, Ellen Christine Løkkegaard, Anne Lis Englund, Merete Husth, Ulla Breth Knudsen, Birgit Alsbjerg, Lisbeth Prætorius, Kristine Løssl, Lone Schmidt, Anja Pinborg
STUDY QUESTION: Are there any differences in physical and psychosocial well-being among women undergoing modified natural cycle frozen embryo transfer (mNC-FET) with or without vaginal progesterone as luteal phase support (LPS)? SUMMARY ANSWER: Women undergoing mNC-FET with vaginal progesterone supplementation were more likely to experience physical discomfort but there was no difference in psychosocial well-being between the two groups. WHAT IS KNOWN ALREADY: mNC-FET can be carried out with or without vaginal progesterone as LPS, which has several side-effects...
August 26, 2023: Human Reproduction
G T Lainas, T G Lainas, A A Makris, M V Xenariou, G K Petsas, E M Kolibianakis
STUDY QUESTION: Does follicular flushing increase the number of cumulus-oocyte complexes (COCs) retrieved compared to single aspiration? SUMMARY ANSWER: Follicular flushing significantly increases the number of COCs retrieved compared to single aspiration. WHAT IS KNOWN ALREADY: On the basis of published meta-analyses, follicular flushing does not seem to increase the number of oocytes retrieved, the probability of clinical pregnancy, or that of live birth and has been associated with an increase in the duration of oocyte retrieval...
August 25, 2023: Human Reproduction
L E Verrilli, K Allen-Brady, E B Johnstone, M A Alvord, C K Welt
STUDY QUESTION: How does the number of children in women with primary ovarian insufficiency (POI) compare to the number for control women across their reproductive lifespans? SUMMARY ANSWER: Approximately 14% fewer women with POI will have children, but for those able to have children the median number is 1 less than for age-matched controls. WHAT IS KNOWN ALREADY: Women with POI are often identified when presenting for fertility treatment, but some women with POI already have children and there remains a low chance for pregnancy after the diagnosis...
August 25, 2023: Human Reproduction
Judit Castillo, Alberto de la Iglesia, Marina Leiva, Meritxell Jodar, Rafael Oliva
Proteomic methodologies offer a robust approach to identify and quantify thousands of proteins from semen components in both fertile donors and infertile patients. These strategies provide an unprecedented discovery potential, which many research teams are currently exploiting. However, it is essential to follow a suitable experimental design to generate robust data, including proper purification of samples, appropriate technical procedures to increase identification throughput, and data analysis following quality criteria...
August 25, 2023: Human Reproduction
Mariam B Ratna, Siladitya Bhattacharya, David J McLernon
STUDY QUESTION: Can two prediction models developed using data from 1999 to 2009 accurately predict the cumulative probability of live birth per woman over multiple complete cycles of IVF in an updated UK cohort? SUMMARY ANSWER: After being updated, the models were able to estimate individualized chances of cumulative live birth over multiple complete cycles of IVF with greater accuracy. WHAT IS KNOWN ALREADY: The McLernon models were the first to predict cumulative live birth over multiple complete cycles of IVF...
August 25, 2023: Human Reproduction
Farners Amargant, Luhan T Zhou, Ye Yuan, Asrafun Nahar, Rebecca L Krisher, Lee D Spate, R Michael Roberts, Randall S Prather, Erin E Rowell, Monica M Laronda, Francesca E Duncan
STUDY QUESTION: Does a chemically defined maturation medium supplemented with FGF2, LIF, and IGF1 (FLI) improve in vitro maturation (IVM) of cumulus-oocyte complexes (COCs) obtained from children, adolescents, and young adults undergoing ovarian tissue cryopreservation (OTC)? SUMMARY ANSWER: Although FLI supplementation did not increase the incidence of oocyte meiotic maturation during human IVM, it significantly improved quality outcomes, including increased cumulus cell expansion and mitogen-activated protein kinase (MAPK) expression as well as enhanced transzonal projection retraction...
August 22, 2023: Human Reproduction
D Romualdi, B Ata, S Bhattacharya, E Bosch, M Costello, K Gersak, R Homburg, M Mincheva, R J Norman, T Piltonen, S Dos Santos-Ribeiro, D Scicluna, S Somers, S K Sunkara, H R Verhoeve, N Le Clef
STUDY QUESTION: What is the recommended management for couples presenting with unexplained infertility (UI), based on the best available evidence in the literature? SUMMARY ANSWER: The evidence-based guideline on UI makes 52 recommendations on the definition, diagnosis, and treatment of UI. WHAT IS KNOWN ALREADY: UI is diagnosed in the absence of any abnormalities of the female and male reproductive systems after 'standard' investigations...
August 21, 2023: Human Reproduction
Anna Melgaard, Claus Høstrup Vestergaard, Ulrik Schiøler Kesmodel, Bettina Wulff Risør, Axel Forman, Krina Zondervan, Bodil Hammer Bech, Dorte Rytter
STUDY QUESTION: Do women with endometriosis have higher utilization of primary and secondary healthcare prior to diagnosis compared to women without endometriosis? SUMMARY ANSWER: Women with a hospital-based diagnosis of endometriosis had an overall higher utilization of both primary and secondary healthcare in all 10 years prior to diagnosis. WHAT IS KNOWN ALREADY: Endometriosis is associated with a diagnostic delay, but only a few studies have investigated the potential consequences of this delay with regard to the utilization of healthcare...
August 15, 2023: Human Reproduction
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