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JOURNAL ARTICLE
Kashish Sharma, Omar F Ammar, Juan J Fraire-Zamora, Julia Uraji, Andrew Thomson, Birol Aydin, Max Ezzati, Alessandra Alteri, George Liperis
No abstract text is available yet for this article.
April 22, 2024: Human Reproduction
#2
JOURNAL ARTICLE
Jacques Donnez, Christian Becker, Hugh Taylor, Francisco Carmona Herrera, Olivier Donnez, Andrew Horne, Maciej Paszkowski, Felice Petraglia, Stefan P Renner, Amisha Patel, Mitra Boolell, Elke Bestel, Marie-Madeleine Dolmans
STUDY QUESTION: Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also known as norethisterone acetate [NETA]) demonstrate better efficacy than placebo in the management of endometriosis-related dysmenorrhea and non-menstrual pelvic pain? SUMMARY ANSWER: Combining 200 mg linzagolix with ABT was found to significantly reduce dysmenorrhea and non-menstrual pelvic pain at 3 months of therapy, while a daily dose of 75 mg linzagolix yielded a significant decrease only in dysmenorrhea at 3 months...
April 22, 2024: Human Reproduction
#3
JOURNAL ARTICLE
E Clain, L K Kaizer, M D Sammel, J Wang, M Homer, M Uhler, L R Hoyos, K Devine, A J Polotsky
STUDY QUESTION: Does BMI of gestational carriers (GCs) affect perinatal outcomes after embryo transfer? SUMMARY ANSWER: Overweight and class I obesity in GCs does not affect the rate of good perinatal outcomes. WHAT IS KNOWN ALREADY: The use of GCs is increasing, but uniform guidance regarding optimal BMI for GCs is lacking. Women with obesity who conceive without fertility treatment or through autologous or donor in vitro fertilization are at higher risk of adverse maternal and fetal outcomes, but data on obesity in GCs are very limited...
April 18, 2024: Human Reproduction
#4
JOURNAL ARTICLE
X Vendrell, P de Castro, L Escrich, N Grau, R Gonzalez-Martin, A Quiñonero, M J Escribá, F Domínguez
STUDY QUESTION: How do transcriptomics vary in haploid human androgenote embryos at single cell level in the first four cell cycles of embryo development? SUMMARY ANSWER: Gene expression peaks at the fourth cell cycle, however some androcytes exhibit unique transcriptional behaviors. WHAT IS KNOWN ALREADY: The developmental potential of an embryo is determined by the competence of the oocyte and the sperm. However, studies of the contribution of the paternal genome using pure haploid androgenotes are very scarce...
April 15, 2024: Human Reproduction
#5
JOURNAL ARTICLE
S Lee, M V Tejesvi, E Hurskainen, O Aasmets, J Plaza-Díaz, S Franks, L Morin-Papunen, J S Tapanainen, T S Ruuska, S Altmäe, E Org, A Salumets, R K Arffman, T T Piltonen
STUDY QUESTION: How does the gut bacteriome differ based on mood disorders (MDs) in women with polycystic ovary syndrome (PCOS), and how can the gut bacteriome contribute to the associations between these two conditions? SUMMARY ANSWER: Women with PCOS who also have MDs exhibited a distinct gut bacteriome with reduced alpha diversity and a significantly lower abundance of Butyricicoccus compared to women with PCOS but without MDs. WHAT IS KNOWN ALREADY: Women with PCOS have a 4- to 5-fold higher risk of having MDs compared to women without PCOS...
April 13, 2024: Human Reproduction
#6
EDITORIAL
Youhong Liu, Ying Yang, Long Wang
No abstract text is available yet for this article.
April 12, 2024: Human Reproduction
#7
EDITORIAL
Junwu Zhang, Yun Sun
No abstract text is available yet for this article.
April 12, 2024: Human Reproduction
#8
JOURNAL ARTICLE
Yao Lu, Yaqiong He, Yuan Wang, Qinling Zhu, Jia Qi, Xinyu Li, Ying Ding, Jiaan Huang, Ziyin Ding, Yurui Xu, Yanan Yang, Steven R Lindheim, Zhe Wei, Yun Sun
STUDY QUESTION: Does severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the frozen-thawed embryo transfer (FET) cycle affect embryo implantation and pregnancy rates? SUMMARY ANSWER: There is no evidence that SARS-CoV-2 infection of women during the FET cycle negatively affects embryo implantation and pregnancy rates. WHAT IS KNOWN ALREADY: Coronavirus disease 2019 (COVID-19), as a multi-systemic disease, poses a threat to reproductive health...
April 11, 2024: Human Reproduction
#9
JOURNAL ARTICLE
Danah Kamphuis, Rik van Eekelen, Nienke van Welie, Kim Dreyer, Joukje van Rijswijk, Machiel H A van Hooff, Jan Peter de Bruin, Harold R Verhoeve, Femke Mol, Wilhelmina M van Baal, Maaike A F Traas, Arno M van Peperstraten, Arentje P Manger, Judith Gianotten, Cornelia H de Koning, Aafke M H Koning, Neriman Bayram, David P van der Ham, Francisca P J M Vrouenraets, Michaela Kalafusova, Bob I G van de Laar, Jeroen Kaijser, Arjon F Lambeek, Wouter J Meijer, Frank J M Broekmans, Olivier Valkenburg, Lucy F van der Voet, Jeroen van Disseldorp, Marieke J Lambers, Rachel Tros, Cornelis B Lambalk, Jaap Stoker, Madelon van Wely, Patrick M M Bossuyt, Ben Willem J Mol, Velja Mijatovic
STUDY QUESTION: What are the costs and effects of tubal patency testing by hysterosalpingo-foam sonography (HyFoSy) compared to hysterosalpingography (HSG) in infertile women during the fertility work-up? SUMMARY ANSWER: During the fertility work-up, clinical management based on the test results of HyFoSy leads to slightly lower, though not statistically significant, live birth rates, at lower costs, compared to management based on HSG results. WHAT IS KNOWN ALREADY: Traditionally, tubal patency testing during the fertility work-up is performed by HSG...
April 10, 2024: Human Reproduction
#10
JOURNAL ARTICLE
Camille Vatier, Sophie Christin-Maitre
Polycystic ovary syndrome (PCOS) affects 6-20% of reproductive-aged women. It is associated with increased risks of metabolic syndrome, Type 2 diabetes, cardiovascular diseases, mood disorders, endometrial cancer and non-alcoholic fatty liver disease. Although various susceptibility loci have been identified through genetic studies, they account for ∼10% of PCOS heritability. Therefore, the etiology of PCOS remains unclear. This review explores the role of epigenetic changes and modifications in circadian clock genes as potential contributors to PCOS pathogenesis...
April 10, 2024: Human Reproduction
#11
JOURNAL ARTICLE
Ping Cao, Josien Derhaag, Edith Coonen, Han Brunner, Ganesh Acharya, Andres Salumets, Masoud Zamani Esteki
STUDY QUESTION: Can generative artificial intelligence (AI) models produce high-fidelity images of human blastocysts? SUMMARY ANSWER: Generative AI models exhibit the capability to generate high-fidelity human blastocyst images, thereby providing substantial training datasets crucial for the development of robust AI models. WHAT IS KNOWN ALREADY: The integration of AI into IVF procedures holds the potential to enhance objectivity and automate embryo selection for transfer...
April 10, 2024: Human Reproduction
#12
JOURNAL ARTICLE
Claudia Massarotti, Omar F Ammar, George Liperis, Mina Mincheva, Juan J Fraire-Zamora, Kashish Sharma, Roseanne Rosario, Amy L Winship, Matteo Lambertini, Sofia Makieva
No abstract text is available yet for this article.
April 9, 2024: Human Reproduction
#13
JOURNAL ARTICLE
Johan Paulin, Kimmo Sorjonen, Gunilla Sydsjö, Claudia Lampic
STUDY QUESTION: Can the application of the theory of planned behavior (TPB) help predict heterosexual parents' disclosure of donor conception to their children? SUMMARY ANSWER: Parents with a stronger will to act in accordance with social norms favoring disclosure were more likely to start the disclosure process within the next 5-9 years. WHAT IS KNOWN ALREADY: In contrast to single mothers by choice and same-sex couples, heterosexual couples need to make an active decision to disclose their use of donor conception to their child...
April 9, 2024: Human Reproduction
#14
JOURNAL ARTICLE
Lu Li, Xingyu Bi, Xueqing Wu, Zhongrong Chen, Yunxia Cao, Gang Zhao
STUDY QUESTION: Can the addition of late embryogenesis-abundant (LEA) proteins as a cryoprotective agent during the vitrification cryopreservation of in vitro matured oocytes enhance their developmental potential after fertilization? SUMMARY ANSWER: LEA proteins improve the developmental potential of human in vitro matured oocytes following cryopreservation, mostly by downregulating FOS genes, reducing oxidative stress, and inhibiting the formation of ice crystals...
April 9, 2024: Human Reproduction
#15
JOURNAL ARTICLE
Kai P Willführ, Sebastian Klüsener
There is strong individual-level evidence that late fatherhood is related to a wide range of health disorders and conditions in offspring. Over the last decades, mean paternal ages at childbirth have risen drastically. This has alarmed researchers from a wide range of fields. However, existing studies have an important shortcoming in that they lack a long-term perspective. This article is a step change in providing such a long-term perspective. We unveil that in many countries the current mean paternal ages at childbirth and proportions of fathers of advanced age at childbirth are not unprecedented...
April 3, 2024: Human Reproduction
#16
JOURNAL ARTICLE
Leesa Van Niekerk, Shaunagh Pugh, Antonina Mikocka-Walus, Cecilia Ng, Rebecca O'Hara, Mike Armour, Mathew Leonardi, Subhadra Evans
STUDY QUESTION: What is the relationship between sexual function, health-related quality of life (HRQoL), and laparoscopic surgery in individuals living with endometriosis? SUMMARY ANSWER: A higher number of laparoscopic surgeries is significantly associated with poorer HRQoL and greater levels of sexual dysfunction in individuals with endometriosis. WHAT IS KNOWN ALREADY: Prior research indicates that endometriosis is associated with lowered HRQoL and sexual function and that these outcomes are influenced by endometriosis-related symptom profiles, medical, and surgical management...
April 1, 2024: Human Reproduction
#17
JOURNAL ARTICLE
Tammy Lee, Kelli Peirce, Jay Natalwala, Vincent Chapple, Peter J Mark, Katherine Sanders, Yanhe Liu
STUDY QUESTION: Do embryos displaying abnormal cleavage (ABNCL) up to Day 3 have compromised live birth rates and neonatal outcomes if full blastulation has been achieved prior to transfer? SUMMARY ANSWER: ABNCL is associated with reduced full blastulation rates but does not impact live birth rates and neonatal outcomes once full blastulation has been achieved. WHAT IS KNOWN ALREADY?: It is widely accepted that ABNCL is associated with reduced implantation rates of embryos when transferred at the cleavage stage...
March 29, 2024: Human Reproduction
#18
JOURNAL ARTICLE
Catarina Mendes Godinho, Sérgio Reis Soares, Sofia Gouveia Nunes, Juan M Mascarós Martínez, Samuel Santos-Ribeiro
STUDY QUESTION: How does a natural proliferative phase (NPP) strategy for frozen embryo transfer (FET) compare with the conventional artificial (AC) and natural (NC) endometrial preparation protocols in terms of live birth rates (LBR)? SUMMARY ANSWER: This study supports the hypothesis that, just as for NC, NPP-FET may be a superior alternative to AC in terms of LBR. WHAT IS KNOWN ALREADY: Although FETs are increasing worldwide, the optimal FET protocol is still largely controversial...
March 26, 2024: Human Reproduction
#19
JOURNAL ARTICLE
Claudia Massarotti, Juan J Fraire-Zamora, George Liperis, Julia Uraji, Kashish Sharma, Munevver Serdarogullari, Omar F Ammar, Sofia Makieva, Zoya E Ali, Daniela Romualdi, Edgardo Somigliana, Denny Sakkas, Eline Dancet, Mina Mincheva
No abstract text is available yet for this article.
March 26, 2024: Human Reproduction
#20
JOURNAL ARTICLE
Jian-Shiun Chiou, Ying-Ju Lin, Cherry Yin-Yi Chang, Wen-Miin Liang, Ting-Yuan Liu, Jai-Sing Yang, Chen-Hsing Chou, Hsing-Fang Lu, Mu-Lin Chiu, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, I-Ching Chou, Te-Mao Li, Peng-Yan Huang, Tzu-Shun Chien, Hou-Ren Chen, Fuu-Jen Tsai
STUDY QUESTION: Are there associations of age at menarche (AAM) with health-related outcomes in East Asians? SUMMARY ANSWER: AAM is associated with osteoporosis, Type 2 diabetes (T2D), glaucoma, and uterine fibroids, as demonstrated through observational studies, polygenic risk scores, genetic correlations, and Mendelian randomization (MR), with additional findings indicating a causal effect of BMI and T2D on earlier AAM. WHAT IS KNOWN ALREADY: Puberty timing is linked to adult disease risk, but research predominantly focuses on European populations, with limited studies in other groups...
March 25, 2024: Human Reproduction
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