Joanna K M Ng, Joshua J X Li, Billy S W Lai, Julia Y Tsang, Agnes W S Chan, Christina Mt Cheung, Edric Cc Ip, Gary M Tse
BACKGROUND: WT1 immunostain is expressed in various benign and malignant neoplasms, as well as normal myoepithelial cells. WT1 shows differential expression in non-neoplastic, benign, and malignant neoplastic myoepithelial cells of the salivary gland. In this study, WT1 immunostain and other myoepithelial markers were compared to investigate the value of WT1 as a myoepithelial marker, and to delineate the expression profile of WT1 in non-salivary gland myoepithelial cells. METHODS: WT1, p63 and calponin immunostains were performed on normal and lesional tissues from the breast (adenosis, sclerosing adenosis, lactating adenoma, nipple adenoma, tubular adenoma, adenomyoepithelioma and adenoid cystic carcinoma (ACC)), skin (cutaneous mixed tumor, hidradenoma, spiradenoma and ACC), and salivary gland (pleomorphic adenoma and ACC)...
February 3, 2023: Human Pathology