Mònica Gonzàlez-Farré, Joan Gibert, Pablo Santiago, Silvia Menéndez, Xavier Montzonis, Francesc Olivares, Xènia Riera, David López, Ariadna Torner, Beatriz Casado, Beatriz Bellosillo, Belén Lloveras, David Casadevall, Ana Rovira, Sònia Servitja, Joan Albanell, Ivonne Vázquez, Laura Comerma
Stromal tumor infiltrating lymphocytes (sTIL) are a robust prognostic and predictive biomarker in triple negative breast carcinoma (TNBC). However, the sTIL compartment comprises different cell populations. The aim of the study is to characterize the distribution of T cells (CD3+ and CD8+), B cells and plasma cells, and explore their association with outcome in the surgical specimen of 62 patients. Furthermore, PD-L1 expression and the presence of tertiary lymphoid structures (TLS) are explored. Patients with higher sTIL achieve better progression free survival (PFS) (P=0...
July 28, 2023: Human Pathology