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HIV Medicine

S Amele, L Peters, M Sluzhynska, A Yakovlev, A Scherrer, P Domingo, J Gerstoft, J P Viard, M Gisinger, R Flisiak, S Bhaghani, M Ristola, C Leen, E Jablonowska, G Wandeler, H Stellbrink, K Falconer, A D'Arminio Monforte, A Horban, J K Rockstroh, J D Lundgren, A Mocroft
OBJECTIVES: The aim of the study was to establish a methodology for evaluating the hepatitis C continuum of care in HIV/hepatitis C virus (HCV)-coinfected individuals and to characterize the continuum in Europe on 1 January 2015, prior to widespread access to direct-acting antiviral (DAA) therapy. METHODS: Stages included in the continuum were as follows: anti-HCV antibody positive, HCV RNA tested, currently HCV RNA positive, ever HCV RNA positive, ever received HCV treatment, completed HCV treatment, follow-up HCV RNA test, and cure...
February 8, 2019: HIV Medicine
D De Francesco, J Underwood, E Bagkeris, M Boffito, F A Post, Pwg Mallon, J H Vera, I Williams, J Anderson, M Johnson, C A Sabin, A Winston
OBJECTIVES: We investigated whether differences in cognitive performance between people living with HIV (PLWH) and comparable HIV-negative people were mediated or moderated by depressive symptoms and lifestyle factors. METHODS: A cross-sectional study of 637 'older' PLWH aged ≥ 50 years, 340 'younger' PLWH aged < 50 years and 276 demographically matched HIV-negative controls aged ≥ 50 years enrolled in the Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study was performed...
February 8, 2019: HIV Medicine
J-M Jacquet, H Donnadieu-Rigole, M Peries, A Makinson, N Nagot, J Reynes, H Peyriere
OBJECTIVES: Screening, brief intervention and referral to treatment (SBIRT) is an evidence-based practice used to identify, reduce and prevent problematic use and abuse of, and dependence on, tobacco, alcohol and psychoactive substances. To date, the pertinence of this practice among people living with HIV (PLHIV) is unknown. In this pilot study, we aimed to assess the acceptability of SBIRT in a cohort of HIV-infected out-patients who were asked about their consumption of alcohol, tobacco and psychoactive substances...
January 31, 2019: HIV Medicine
S M Johnson, J F Standing, N Klein, A D Irwin, D Shingadia, D O Lonsdale, K C Gilmour, J Flynn, C Manns, M Clapson, A Bamford
No abstract text is available yet for this article.
January 28, 2019: HIV Medicine
S Grabar, M Hleyhel, A Belot, A-M Bouvier, P Tattevin, J Pacanowski, P Genet, C Pradier, D Salmon, A Simon, V Pourcher, J-P Spano, I Poizot-Martin, D Costagliola
OBJECTIVES: We examined trends in the incidence rates of invasive cervical cancer (ICC) and in the rate of survival after ICC among women living with HIV (WLHIV) in France and compared them to those of the general population. METHODS: Histologically validated incident cases of ICC in the period 1992-2009 from the French Hospital Database on HIV (FHDH-ANRS CO4) were included in the study. Age-standardized incidence rates were estimated for FHDH and the general population in France for 1992-1996 [pre-combination antiretroviral therapy (cART) period], 1997-2000 (early cART period), 2001-2004 (intermediate cART period), and 2005-2009 (late cART period)...
January 28, 2019: HIV Medicine
G Ireland, R Simmons, K Balogun, P Kirwan, C A Sabin, M Ramsay, V Delpech, S Mandal
OBJECTIVES: The aim of the study was to estimate HIV prevalence among persons with hepatitis B virus (HBV) infection in England and to examine associated risk factors. METHODS: Persons aged ≥ 15 years with an HBV surface antigen (HBsAg) test reported to Public Health England (PHE) sentinel surveillance during 2008-2014 were linked to the PHE national HIV/AIDS database. Coinfection was defined as an HIV diagnosis prior to, or within 6 months following, a positive HBsAg test...
January 28, 2019: HIV Medicine
M Matignon, J-D Lelièvre, A Lahiani, K Abbassi, D Desvaux, A Diallo, M-N Peraldi, A-M Taburet, J Saillard, C Delaugerre, D Costagliola, L Assoumou, P Grimbert
OBJECTIVES: High rates of clinical acute rejection after kidney transplantation have been reported in people living with HIV (PLHIV), probably as a consequence of drug interactions. We therefore investigated the incidence of acute rejection within 6 months of transplantation in HIV-infected recipients treated with a protease-inhibitor-free raltegravir-based regimen. METHODS: The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) 153 TREVE (NCT01453192) study was a prospective multicentre single-arm trial in adult PLHIV awaiting kidney transplantation, with viral load < 50 HIV-1 RNA copies/mL, CD4 T-cell count > 200 cells/μL, and HIV-1 strains sensitive to raltegravir, aiming to demonstrate 6-month clinical acute rejection rates < 30%...
January 27, 2019: HIV Medicine
J M Llibre, A Montoliu, J M Miró, P Domingo, M Riera, J Tiraboschi, A Curran, F Homar, J Ambrosioni, N Abdulghani, L Force, J Peraire, J Casabona
OBJECTIVES: The aim of the study was to assess the rates of discontinuation of integrase inhibitor regimens because of any neuropsychiatric adverse event (NPAE) and the factors associated with discontinuation. METHODS: A population-based, prospective, multicentre cohort study was carried out. Treatment-naïve subjects starting therapy with a regimen containing integrase inhibitors, or those switching to such a regimen, with plasma HIV-1 RNA < 50 HIV-1 RNA copies/mL in 14 hospitals in Catalonia or the Balearic Islands (Spain) were included in the study...
January 27, 2019: HIV Medicine
J J Malin, C Boesecke, C Schwarze-Zander, J C Wasmuth, S Schlabe, J Trebicka, U Spengler, J M Llibre, T Jou, M Vasylyev, B Clotet, J K Rockstroh
OBJECTIVES: The aim of the study was to assess the regression of liver stiffness after successful direct-acting antiviral (DAA) treatment in patients with hepatitis C virus (HCV) monoinfection and HCV/-HIV coinfection. In addition, we aimed to identify factors associated with liver stiffness regression. METHODS: We studied patients treated with interferon-free DAA regimens with a sustained virological response at week 12 (SVR12 ) or 24 (SVR24 ) post-treatment. Liver stiffness was assessed by transient elastography (TE) before the initiation and after the end of treatment (median 12 weeks)...
January 27, 2019: HIV Medicine
C Colomba, L Saporito, C Gioè, F Tramuto, A Firenze, A Cascio
No abstract text is available yet for this article.
January 22, 2019: HIV Medicine
H B Krentz, S Campbell, M Lahl, M J Gill
OBJECTIVES: As more HIV-positive individuals receive antiretroviral therapy (ART), payers are seeking options for covering these increased and sustained drug costs. Strategic use of available generic antiretroviral (ARV) formulations may be feasible. De-simplifying a single-tablet co-formulation (STF) into two or more tablets using both brand and generic drugs has been proposed. We determine if voluntary de-simplification of one STF could be utilized as a cost-saving strategy. We report on the challenges, uptake, outcomes and cost savings of this initiative...
January 11, 2019: HIV Medicine
S Dakshina, I D Olaru, P Khan, L Raman, G McHugh, M Bwakura-Dangarembizi, K Nathoo, S Munyati, H Mujuru, R A Ferrand
OBJECTIVES: The aim of the study was to investigate the extent of and factors associated with incorrect dosing of antiretroviral therapy (ART) in HIV-infected children in Harare, Zimbabwe. METHODS: All children aged 0-10 years and children aged 11-17 years who weighed < 35 kg and taking ART were recruited from the paediatric HIV clinic at Harare Hospital. Their current doses of ART drugs were compared against doses recommended by the national guidelines. RESULTS: Among 309 children recruited [55% male; median age 7 years (interquartile range (IQR) 5-10 years)], the median CD4 count was 899 cells/μL and the median duration of their current ART regimen was 11...
January 11, 2019: HIV Medicine
C T Costiniuk, R Nitulescu, Z Saneei, N Wasef, S Salahuddin, D Wasef, J Young, C de Castro, J P Routy, B Lebouché, J Cox, B M Smith, S Ambroise, C Pexos, M Patel, J Szabo, L P Haraoui, A de Pokomandy, C Tsoukas, J Falutz, R LeBlanc, A Giannakis, C Frenette, M A Jenabian, J Bourbeau, M B Klein
OBJECTIVES: The reported prevalence of chronic obstructive pulmonary disease (COPD) in people living with HIV (PLWHIV) varies widely. Our objective was to estimate the prevalence of airflow obstruction and COPD in unselected PLWHIV and identify characteristics that increase the risk of nonreversible airflow obstruction in order to guide case finding strategies for COPD. METHODS: All adults attending the Chronic Viral Illness Service were invited to participate in the study, regardless of smoking status or history of known COPD/asthma...
January 8, 2019: HIV Medicine
R Bijker, A Jiamsakul, E Uy, N Kumarasamy, R Ditango, R Chaiwarith, W W Wong, A Avihingsanon, L P Sun, E Yunihastuti, S Pujari, C D Do, T P Merati, P Kantipong, K V Nguyen, A Kamarulzaman, F Zhang, M P Lee, J Y Choi, J Tanuma, O T Ng, Blh Sim, J Ross, S Kiertiburanakul
OBJECTIVES: With aging of the HIV-positive population, cardiovascular disease (CVD) increasingly contributes to morbidity and mortality. We investigated CVD-related and other causes of death (CODs) and factors associated with CVD in a multi-country Asian HIV-positive cohort. METHODS: Patient data from 2003-2017 were obtained from the Therapeutics, Research, Education and AIDS Training in Asia (TREAT Asia) HIV Observational Database (TAHOD). We included patients on antiretroviral therapy (ART) with > 1 day of follow-up...
January 8, 2019: HIV Medicine
D C Griffith, C Farmer, K A Gebo, S A Berry, J Aberg, R D Moore, A H Gaur, W C Mathews, R Beil, P T Korthuis, A E Nijhawan, R M Rutstein, A L Agwu
OBJECTIVES: Several single-tablet regimens (STRs) are now available and are recommended for first-line antiretroviral therapy (ART); however, STR use for youth with HIV (YHIV) has not been systematically studied. We examined the characteristics associated with initiation of STRs versus multi-tablet regimens (MTRs) and the virological outcomes for youth with nonperinatally acquired HIV (nPHIV). METHODS: A retrospective cohort study of nPHIV youth aged 13-24 years initiating ART between 2006 and 2014 at 18 US HIV clinical sites in the HIV Research Network was performed...
December 18, 2018: HIV Medicine
Erm Pool, A Winston, E Bagkeris, J H Vera, Pwg Mallon, M Sachikonye, F A Post, A Pozniak, M Boffito, J Anderson, I Williams, M Johnson, L Burgess, C A Sabin
OBJECTIVES: To investigate the patterns and frequency of multiple risk behaviours (alcohol, drugs, smoking, higher risk sexual activity) among men who have sex with men (MSM) living with HIV. METHODS: Cross sectional study. RESULTS: 819 HIV-positive MSM exhibited a high-risk phenotype (defined as >3 of smoking, excess alcohol, sexually transmitted infection and recent recreational drug use). This phenotype was associated with younger age, depressive symptoms and <90% adherence in multivariable logistic regression...
December 12, 2018: HIV Medicine
C Gatey, A Brun, G Hamet, S Diamantis, P Sellier, O Bouchaud, V Garrait, W Rozenbaum, J M Molina, S Abgrall
OBJECTIVES: The aim of the study was to assess whether the timing of combination antiretroviral therapy (cART) initiation, the choice of cART and virological response differ in migrants versus European natives in the north and east of Paris area, after dissemination of French recommendations for universal treatment. METHODS: Antiretroviral therapy-naïve HIV-1-infected adults with at least two follow-up visits at one of 15 participating centres between 1 January 2014 and 31 March 2015 were included in the study...
December 3, 2018: HIV Medicine
R Puhr, K Petoumenos, R Huang, D J Templeton, I Woolley, M Bloch, D Russell, M G Law, D A Cooper
OBJECTIVES: As HIV-positive people age, diagnosis and management of comorbidities associated with ageing are of increasing concern. In this study, we aimed to compare the self-reported prevalences of heart disease, stroke, thrombosis and diabetes in older Australian HIV-positive and HIV-negative gay and bisexual men (GBM). METHODS: We analysed data from the Australian Positive & Peers Longevity Evaluation Study (APPLES), a study of a prospectively recruited cross-sectional sample of 228 (51...
November 26, 2018: HIV Medicine
C E Kendall, J Raboud, J Donelle, M Loutfy, S B Rourke, A Kroch, C Liddy, R Rosenes, A N Burchell
OBJECTIVES: Selection as a consequence of volunteer participation in, and loss to follow-up from, cohort studies may bias estimates of mortality and other health outcomes. To quantify this potential, we estimated mortality and health service use among people living with HIV (PLWH) who were lost to cohort follow-up (LTCFU) from a volunteer clinical HIV-infected cohort, and compared these to mortality and health service use in active cohort participants and non-cohort-participants living with HIV in Ontario, Canada...
November 26, 2018: HIV Medicine
B T Tadesse, B A Foster, A Kabeta, F Ayalew, G H/Meskel, D Jerene, E Makonnen, E Aklillu
OBJECTIVES: The aim of the study was to investigate the prevalence of renal function and liver enzyme abnormalities among HIV-infected children, changes in prevalence with time on combination antiretroviral therapy (cART), and the factors associated with these abnormalities. METHODS: A prospective cohort study was conducted among HIV-infected children < 18 years old (n = 705) who were on first-line cART. Liver enzymes, renal function, haematology, immunology and virological response were assessed at enrolment and followed bi-annually for 18 months...
November 26, 2018: HIV Medicine
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