Saad Nadeem, Matthew G Hanna, Kartik Viswanathan, Joseph Marino, Mahsa Ahadi, Bayan Alzumaili, Mohamed-Amine Bani, Federico Chiarucci, Angela Chou, Antonio De Leo, Talia L Fuchs, Daniel J Lubin, Catherine Luxford, Kelly Magliocca, Germán Martinez, Qiuying Shi, Stan Sidhu, Abir Al Ghuzlan, Anthony J Gill, Giovanni Tallini, Ronald Ghossein, Bin Xu
AIMS: The International Medullary Thyroid Carcinoma Grading System, introduced in 2022, mandates evaluation of the Ki67 proliferation index to assign a histological grade for medullary thyroid carcinoma. However, manual counting remains a tedious and time-consuming task. METHODS AND RESULTS: We aimed to evaluate the performance of three other counting techniques for the Ki67 index, eyeballing by a trained experienced investigator, a machine learning-based deep learning algorithm (DeepLIIF) and an image analysis software with internal thresholding compared to the gold standard manual counting in a large cohort of 260 primarily resected medullary thyroid carcinoma...
September 14, 2023: Histopathology