journal
https://read.qxmd.com/read/37232543/encapsulated-papillary-carcinoma-of-the-breast-does-it-have-a-native-basement-membrane
#1
JOURNAL ARTICLE
Suzan F Ghannam, Catrin S Rutland, Cinzia Allegrucci, Nigel P Mongan, Emad Rakha
BACKGROUND: Encapsulated papillary carcinoma (EPC) is surrounded by a thick fibrous capsule-like structure, which is interpreted as a thickened basement membrane (BM). This study aimed to describe the geometric characteristics of the EPC capsule and to refine whether it is an expansion of the BM or a stromal reactive process. MATERIAL AND METHODS: In all, 100 cases were divided into four groups: EPC, ductal carcinoma in situ (DCIS), normal breast tissue and invasive tumours, with an additional encapsulated papillary thyroid carcinoma (EPTC) control group...
May 26, 2023: Histopathology
https://read.qxmd.com/read/37222669/characteristics-and-prognostic-significance-of-polo-like-kinase-1-plk1-expression-in-breast-cancer
#2
JOURNAL ARTICLE
Ayat G Lashen, Michael S Toss, Louisa Wootton, Andrew R Green, Nigel P Mongan, Srinivasan Madhusudan, Emad Rakha
AIM: Polo-like kinase-1 (PLK1) plays a crucial role in cell cycle progression, and it is considered a potential therapeutic target in many cancers. Although the role of PLK1 is well established in triple-negative breast cancer (TNBC) as an oncogene, its role in luminal BC is still controversial. In this study, we aimed to evaluate the prognostic and predictive role of PLK1 in BC and its molecular subtypes. METHODS: A large BC cohort (n = 1208) were immunohistochemically stained for PLK1...
May 24, 2023: Histopathology
https://read.qxmd.com/read/37222207/use-of-orcein-as-an-adjunct-stain-in-the-evaluation-of-advanced-fibrosis
#3
JOURNAL ARTICLE
Eric D Nguyen, Chien-Kuang Cornelia Ding, Sarah E Umetsu, Won-Tak Choi, Linda D Ferrell, Kwun Wah Wen
AIMS: Advanced liver fibrosis can regress following the elimination of causative injuries. Trichrome (TC) stain has traditionally been used to evaluate the degree of fibrosis in liver, although it is rarely helpful in assessing quality of fibrosis (i.e. progression and regression). Orcein (OR) stain highlights established elastic fibres, but its use in examining fibrosis is not well recognised. This study assessed the potential utility of comparing OR and TC staining patterns to evaluate the quality of fibrosis in various settings of advanced fibrosis...
May 24, 2023: Histopathology
https://read.qxmd.com/read/37222201/eosinophil-rich-variant-of-nodal-marginal-zone-lymphoma-a-clinicopathological-study-of-11-cases
#4
JOURNAL ARTICLE
Misayo Miyake, Seiji Sakata, Naoko Tsuyama, Yuki Togashi, Masaaki Noguchi, Nobuhiro Tsukada, Takashi Kumagai, Yuko Mishima, Kengo Takeuchi
AIMS: Tissue eosinophilia is commonly observed in T-cell and classic Hodgkin lymphomas, but rarely in B-cell lymphomas. Herein, we present the first report of a case series on nodal marginal zone lymphoma (NMZL) with tissue eosinophilia. METHODS AND RESULTS: All 11 patients in this study had nodal disease at primary presentation. The mean age at diagnosis was 64 years. The mean follow-up period was 39 months, and all patients were alive. Nine of the 11 patients (82%) showed no recurrence, but the other two patients experienced recurrence in the lymph nodes or skin...
May 24, 2023: Histopathology
https://read.qxmd.com/read/37222200/pathological-overview-of-steatohepatitic-hepatocellular-carcinoma-in-a-surgical-series
#5
JOURNAL ARTICLE
Loïc Trapani, Aurélie Beaufrère, Christian Hobeika, Tatiana Codjia, Miguel Albuquerque, Mohamed Bouattour, Mickael Lesurtel, François Cauchy, Valérie Paradis
AIMS: According to the last WHO classification, steatohepatitic hepatocellular carcinoma (SH-HCC) is recognized as a distinct HCC subtype, even though a consensual definition is still lacking. The objectives of the study were to carefully describe the morphological features of SH-HCC and evaluate its impact on prognosis. METHODS AND RESULTS: We conducted a single-centre retrospective study including 297 surgically resected HCC. Pathological features including SH criteria (steatosis, ballooning, Mallory-Denk bodies, fibrosis, and inflammation) were assessed...
May 24, 2023: Histopathology
https://read.qxmd.com/read/37222195/genomic-profiling-of-dedifferentiated-endometrial-carcinomas-arising-in-the-background-of-high-grade-carcinoma-a-targeted-next-generation-sequencing-study
#6
JOURNAL ARTICLE
Ekaterina Olkhov-Mitsel, Aurelia Busca, Carlos Parra-Herran, Yutaka Amemiya, Sharon Nofech-Mozes, Bojana Djordjevic, Marisa R Nucci, Arun Seth, Jelena Mirkovic
AIMS: Our understanding of dedifferentiated endometrial carcinoma (DEC), a rare and aggressive malignancy, mainly reflects undifferentiated carcinomas (UC) arising in the setting of low-grade endometrial cancer (DEC-LG). However, cases of UC arising in the setting of high-grade EC (DEC-HG) have been noted in the literature. Our knowledge of the genomics of DEC-HG is limited. To characterise the molecular landscape of DEC-HC, targeted genomic sequencing and immunohistochemical analysis was carried out on seven DEC-HG and four DEC-LG...
May 24, 2023: Histopathology
https://read.qxmd.com/read/37211641/hyalinizing-clear-cell-carcinoma-of-the-lung-with-ewsr1-crem-fusion
#7
JOURNAL ARTICLE
Vincent Grosjean, Pierre Fournel, Tiphanie Picot, Olivier Tiffet, Fabien Forest
No abstract text is available yet for this article.
May 21, 2023: Histopathology
https://read.qxmd.com/read/37199687/degree-of-crypt-atypia-correlates-with-progression-to-high-grade-dysplasia-adenocarcinoma-in-non-dysplastic-barrett-s-oesophagus
#8
JOURNAL ARTICLE
Robert Odze, Nicola Frei, Amir M Khoshiwal, Lucas C Duits, Jacques Bergman, Matthew D Stachler
AIMS: Patients with non-dysplastic Barrett's oesophagus (BE) often show a wide range of 'atypical' histological features in the bases of the crypts. However, the significance of crypt atypia has never been evaluated, despite prior studies showing the presence of DNA content and other molecular abnormalities in this epithelium. The aim of this study was to evaluate whether the degree of crypt atypia in BE patients without dysplasia correlates with progression to high-grade dysplasia/adenocarcinoma (HGD/EAC)...
May 18, 2023: Histopathology
https://read.qxmd.com/read/37199682/recurrent-pak2-rearrangements-in-poroma-with-folliculo-sebaceous-differentiation
#9
JOURNAL ARTICLE
Thibault Kervarrec, Daniel Pissaloux, Sandrine Paindavoine, Franck Tirode, Amélie Osio, Samia Mourah, Fanélie Jouenne, Pierre Sohier, Eduardo Calonje, Agnes Pekar, Evelyn Vanesa Erazo Luna, Keisuke Goto, Flore Delalande, Eric Frouin, Nicolas Macagno, Françoise Drouot, Monique Faisan, Bernard Cribier, Maxime Battistella, Arnaud de la Fouchardière
AIMS: Poroma is a benign adnexal neoplasm with differentiation towards the upper portion of the sweat gland apparatus. In 2019, Sekine et al. demonstrated recurrent YAP1::MAML2 and YAP1::NUTM1 fusion in poroma and porocarcinoma. Follicular, sebaceous and/or apocrine differentiation has been reported in rare cases of poroma and whether these tumours constitute a variant of poroma or represent a distinctive tumour is a matter to debate. Herein we describe the clinical, immunophenotypic, and molecular features of 13 cases of poroma with folliculo-sebaceous differentiation...
May 18, 2023: Histopathology
https://read.qxmd.com/read/37195596/primary-cold-agglutinin-disease-a-recently-recognised-diagnostic-entity-in-who-and-icc
#10
JOURNAL ARTICLE
Magda Zanelli, Maria Elena Nizzoli, Francesca Sanguedolce, Andrea Palicelli, Maurizio Zizzo, Giuseppe Broggi, Rosario Caltabiano, Paola Parente, Stefano Ascani
No abstract text is available yet for this article.
May 17, 2023: Histopathology
https://read.qxmd.com/read/37195595/impact-of-comedonecrosis-on-prostate-cancer-outcome-a-systematic-review
#11
REVIEW
Kaveri T S Aiyer, Lisa J Kroon, Geert J L H van Leenders
Cribriform architecture has been recognised as an independent parameter for prostate cancer outcome. Little is yet known on the added value of individual Gleason 5 growth patterns. Comedonecrosis is assigned Gleason pattern 5 and can occur in both invasive and intraductal carcinoma. The aim of this study is to systematically review the literature for the prognostic value of comedonecrosis in prostate cancer. A systematic literature search of Medline, Web of Science, Cochrane library and Google scholar was performed according to the Preferred reporting items for systematic reviews and meta-analysis (PRISMA)guidelines...
May 17, 2023: Histopathology
https://read.qxmd.com/read/37195579/transcriptomic-and-immunophenotypic-characterization-of-two-cases-of-adamantinoma-like-ewing-sarcoma-of-the-thyroid-gland
#12
JOURNAL ARTICLE
Kyriakos Chatzopoulos, Jaime I Davila, Numrah Fadra, Rory A Jackson, Kay T Minn, Sotiris Sotiriou, Andre M Oliveira, Lori A Erickson, Kevin C Halling, Kandelaria M Rumilla, Michael Rivera
INTRODUCTION: Adamantinoma-like Ewing sarcoma (ALES) is a rare aggressive malignancy occasionally diagnosed in the thyroid gland. ALES shows basaloid cytomorphology, expresses keratins, p63, p40, frequently CD99, and harbours the t(11;22) EWSR1::FLI1 translocation. There is debate on whether ALES resembles more sarcoma or carcinoma. METHODS: We performed RNA sequencing from two ALES cases and compared findings with skeletal Ewing's sarcomas and nonneoplastic thyroid tissue...
May 17, 2023: Histopathology
https://read.qxmd.com/read/37195563/lynch-syndrome-related-colorectal-carcinomas-are-ntrk-negative
#13
LETTER
Andrea Remo, Federica Grillo, Alessandro Vanoli, Paola Parente, Luca Mastracci, Valentina Angerilli, Emanuele Damiano Urso, Francesca Bergamo, Matteo Fassan
No abstract text is available yet for this article.
May 17, 2023: Histopathology
https://read.qxmd.com/read/37145111/lethality-of-sars-cov-2-infection-a-comparative-autopsy-study-focusing-on-covid-19-development-and-virus-variants
#14
JOURNAL ARTICLE
Constantin Schwab, Uta Merle, Peter Schirmacher, Thomas Longerich
AIMS: Different SARS-CoV-2 variants are driving various waves of infection of the corona pandemic. Official statistics provide no information on who died due to coronavirus disease 2019 (COVID-19) or an alternative disease during which SARS-CoV-2 infection was detected. The current study aims at addressing the effect of the different variants evolving during the pandemic on fatal outcomes. METHODS AND RESULTS: Standardised autopsies were performed on 117 people who died of a SARS-CoV-2 infection and the findings were interpreted in clinical and pathophysiological contexts...
May 5, 2023: Histopathology
https://read.qxmd.com/read/37140551/biopsy-prostate-cancer-perineural-invasion-and-tumour-load-are-associated-with-positive-posterolateral-margins-at-radical-prostatectomy-implications-for-planning-of-nerve-sparing-surgery
#15
JOURNAL ARTICLE
Margaretha A van der Slot, Sebastiaan Remmers, Charlotte F Kweldam, Michael A den Bakker, Daan Nieboer, Martijn B Busstra, Melanie Gan, Sjoerd Klaver, John B W Rietbergen, Geert J L H van Leenders
AIMS: Radical prostatectomy (RP) for prostate cancer is frequently complicated by erectile dysfunction and urinary incontinence. However, sparing of the nerve bundles adjacent to the posterolateral sides of the prostate reduces the number of complications at the risk of positive surgical margins. Preoperative selection of men eligible for safe, nerve-sparing surgery is therefore needed. Our aim was to identify pathological factors associated with positive posterolateral surgical margins in men undergoing bilateral nerve-sparing RP...
May 4, 2023: Histopathology
https://read.qxmd.com/read/37140546/bile-duct-adenoma-and-small-sized-small-duct-type-intrahepatic-cholangiocarcinoma-show-distinct-differences-in-genetic-alterations-expression-of-imp3-and-ezh2-and-stromal-and-inflammatory-components
#16
JOURNAL ARTICLE
Sasaki Motoko, Sato Yasunori, Nakanuma Yasuni
AIMS: Given that bile duct adenoma was significantly more prevalent in the liver with small duct type intrahepatic cholangiocarcinoma (small duct iCCA), compared to other primary liver carcinomas, we examined the possibility of bile duct adenoma as a precursor of small duct iCCA by analysing genetic alterations and other features in bile duct adenomas. METHODS AND RESULTS: Subjects included 33 bile duct adenomas and 17 small-sized (up to 2 cm in diameter) small duct iCCAs...
May 4, 2023: Histopathology
https://read.qxmd.com/read/37140543/giant-juvenile-fibroadenomas-with-and-without-prominent%C3%A2-pseudoangiomatous-stromal-hyperplasia-pash-like-change-clinicopathological-and-molecular-characteristics
#17
JOURNAL ARTICLE
Julie M Jorns, Ayesha Farooq, Andrii Puzyrenko, Jason Jarzembowski, Aye Aye Thike, Nur Diyana Md Nasir, Cedric Chuan Young Ng, Wei Liu, Jing Yi Lee, Abner Herbert Lim, Peiyong Guan, Bin Tean Teh, Puay Hoon Tan
AIMS: Juvenile fibroadenomas (JFA) are biphasic fibroepithelial lesions (FEL) usually occurring in adolescent female patients. Giant (G) JFA, like other FEL, may exhibit prominent pseudoangiomatous stromal hyperplasia (PASH)-like change. We sought to determine clinicopathological and molecular characteristics of GJFA with and without PASH. METHODS AND RESULTS: Archives were searched for cases of GJFA (1985-2020). All were stained for androgen receptor (AR), beta-catenin, CD34 and progesterone receptor (PR)...
May 4, 2023: Histopathology
https://read.qxmd.com/read/37102989/vascular-epithelial-changes-as-late-sequelae-after-recovery-from-sars-cov-2-infection-an-in-vivo-comparative-study
#18
JOURNAL ARTICLE
Federica Pezzuto, Francesca Lunardi, Luca Vedovelli, Gheorghe E Olteanu, Francesco Fortarezza, Alessandro De Pellegrin, Luca Melan, Eleonora Faccioli, Elisa De Franceschi, Chiara Giraudo, Claudia Del Vecchio, Serena Marinello, Giulia Pasello, Dario Gregori, Paolo Navalesi, Federico Rea, Marco Schiavon, Fiorella Calabrese
AIMS: While there is partial evidence of lung lesions in patients suffering from long COVID there are substantial concerns about lung remodelling sequelae after COVID-19 pneumonia. The aim of the present retrospective comparative study was to ascertain morphological features in lung samples from patients undergoing tumour resection several months after SARS-CoV-2 infection. METHODS AND RESULTS: The severity of several lesions with a major focus on the vascular bed was analysed in 2 tumour-distant lung fragments of 41 cases: 21 SARS-CoV-2 (+) lung tumour (LT) patients and 20 SARS-CoV-2 (-) LT patients...
April 27, 2023: Histopathology
https://read.qxmd.com/read/37099413/fibroadipose-vascular-anomaly-a-clinicopathological-study-of-75-cases
#19
JOURNAL ARTICLE
Shuang Xue, Qiuyu Liu, Yuewu Zhao, Lingfei Kong, Fangfang Fu, Yubin Gong, Xiaonan Guo, Changxian Dong, Meiyun Wang
AIMS: Fibroadipose vascular anomaly (FAVA) is a complex vascular malformation that is likely to be under-recognised. In this study we aimed to report the pathological features and somatic PIK3CA mutations associated with the most common clinicopathological features. METHODS AND RESULTS: Cases were identified by reviewing the lesions resected from patients with FAVA registered at our Haemangioma Surgery Centre and unusual intramuscular vascular anomalies in our pathology database...
April 26, 2023: Histopathology
https://read.qxmd.com/read/37099411/mir-371a-3p-in-cystic-trophoblastic-tumour-of-the-testis-supporting-a-maturation-phenomenon-towards-teratoma
#20
LETTER
João Lobo, Nuno Tiago Tavares, Daniela Barros-Silva, Alina Rosinha, António Morais, Carmen Jerónimo, Ângelo Rodrigues, Rui Henrique
No abstract text is available yet for this article.
April 26, 2023: Histopathology
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