journal
https://read.qxmd.com/read/38606992/considerable-interlaboratory-variation-in-pd-l1-positivity-for%C3%A2-head-and-neck-squamous-cell-carcinoma-in-the-netherlands-a-nationwide-evaluation-study
#1
JOURNAL ARTICLE
Maaike Anna Hempenius, Bregje M Koomen, Ivette A G Deckers, Sjoukje F Oosting, Stefan M Willems, Bert van der Vegt
AIMS: Patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) are eligible for first-line immune checkpoint inhibition if their tumour is positive for programmed death ligand 1 (PD-L1) determined by the combined positive score (CPS). This nationwide study, using real-world data, investigated the developing PD-L1 testing landscape in the first 3 years after introduction of the test in HNSCC and examined interlaboratory variation in PD-L1 positivity rates...
April 12, 2024: Histopathology
https://read.qxmd.com/read/38606989/histological-interpretation-of-spitzoid-tumours-an-extensive-machine-learning-based-concordance-analysis-for-improving-decision-making
#2
JOURNAL ARTICLE
Andrés Mosquera-Zamudio, Laëtitia Launet, Adrián Colomer, Katharina Wiedemeyer, Juan C López-Takegami, Luis F Palma, Erling Undersrud, Emilius Janssen, Thomas Brenn, Valery Naranjo, Carlos Monteagudo
The histopathological classification of melanocytic tumours with spitzoid features remains a challenging task. We confront the complexities involved in the histological classification of these tumours by proposing machine learning (ML) algorithms that objectively categorise the most relevant features in order of importance. The data set comprises 122 tumours (39 benign, 44 atypical and 39 malignant) from four different countries. BRAF and NRAS mutation status was evaluated in 51. Analysis of variance score was performed to rank 22 clinicopathological variables...
April 12, 2024: Histopathology
https://read.qxmd.com/read/38576274/novel-thbs1-igf1r-fusion-in-myopericytic-tumour
#3
LETTER
Kenichiro Kato, Kyoko Yamashita, Akito Dobashi, Yuki Togashi, Satoko Baba, Keisuke Ae, Seiichi Matsumoto, Kengo Takeuchi
No abstract text is available yet for this article.
April 4, 2024: Histopathology
https://read.qxmd.com/read/38571446/identification-of-tumour-regression-in-neoadjuvantly-treated-pancreatic-cancer-is-based-on-divergent-and-nonspecific-criteria
#4
JOURNAL ARTICLE
Maia Blomhoff Holm, Daniela Lenggenhager, Sönke Detlefsen, Petra Sántha, Caroline Sophie Verbeke
AIMS: Following the increased use of neoadjuvant therapy for pancreatic cancer, grading of tumour regression (TR) has become part of routine diagnostics. However, it suffers from marked interobserver variation, which is mainly ascribed to the subjectivity of the defining criteria of the categories in TR grading systems. We hypothesized that a further cause for the interobserver variation is the use of divergent and nonspecific morphological criteria to identify tumour regression. METHODS AND RESULTS: Twenty treatment-naïve pancreatic cancers and 20 pancreatic cancers treated with neoadjuvant chemotherapy were reviewed by three experienced pancreatic pathologists who, blinded for treatment status, categorized each tumour as treatment-naïve or neoadjuvantly treated, and annotated all tissue areas they considered showing tumour regression...
April 4, 2024: Histopathology
https://read.qxmd.com/read/38571438/exploring-p53-protein-expression-and-its-link-to-tp53-mutation-in-myelodysplasia-related-malignancies-interpretive-challenges-and-potential-field-of-applications
#5
JOURNAL ARTICLE
Judit Bedekovics, Kristóf Madarász, Attila Mokánszki, Sarolta Molnár, Ágnes Mester, Zsófia Miltényi, Gábor Méhes
AIMS: TP53 alterations have a significant prognostic effect in myeloid neoplasms. Our objective was to investigate the TP53 gene mutation status, p53 protein expression and their relationship in dysplasia-related myeloid neoplasms with varying levels of myeloblast counts. METHODS AND RESULTS: A total of 76 bone marrow biopsy samples with different blast counts were analysed. Total and strong (3+) p53 expression was determined. Dual immunohistochemical staining was performed to determine the cell population associated with p53 expression...
April 4, 2024: Histopathology
https://read.qxmd.com/read/38571437/presence-of-focal-usual-interstitial-pneumonia-is-a-key-prognostic-factor-in-progressive-pulmonary-fibrosis
#6
JOURNAL ARTICLE
Yukio Tsushima, Ethan N Okoshi, Sousuke Ishijima, Andrey Bychkov, Kris Lami, Shimpei Morimoto, Yasuhiko Yamano, Kensuke Kataoka, Takeshi Johkoh, Yasuhiro Kondoh, Junya Fukuoka
AIMS: Progressive pulmonary fibrosis (PPF) is a newly recognised clinical phenotype of interstitial lung diseases in the 2022 interstitial pulmonary fibrosis (IPF) guidelines. This category is based entirely on clinical and radiological factors, and the background histopathology is unknown. Our objective was to investigate the histopathological characteristics of PPF and to examine the correlation between usual interstitial pneumonia (UIP) and prognosis in this new disease type. We hypothesised that the presence of UIP-like fibrosis predicts patients' survival in PPF cases...
April 4, 2024: Histopathology
https://read.qxmd.com/read/38566342/carcinoma-arising-in-ileal-conduit-or-orthotopic-ileal-neobladder-reconstruction-a-20-year-single-institute-experience
#7
JOURNAL ARTICLE
Katrina Collins, Bianca Puello Yocum, Muhammad T Idrees, Omer Saeed
CONTEXT: Carcinomas found in urinary diversion specimens are uncommon, particularly new primary tumours. New primary tumours primarily occur when the large intestine is utilised, whereas the occurrence is infrequent with the use of the ileum. These tumours include both the recurrence of primary malignancy or the development of a new primary malignancy originating from the small intestine. DESIGN: A search was performed within the pathology laboratory system to identify cases of malignancies involving ileal conduit/reconstruction from 2002 to 2022...
April 2, 2024: Histopathology
https://read.qxmd.com/read/38566333/an-aggressive-mediastinal-ebv-associated-large-b-cell-lymphoma
#8
LETTER
Katrin S Kurz, Daniel Noerenberg, Markus Schaich, Wolfgang Bethge, Heike Horn, Annette M Staiger, Falko Fend, Frederik Damm, German Ott
No abstract text is available yet for this article.
April 2, 2024: Histopathology
https://read.qxmd.com/read/38566331/alx4-ncoa2-rearranged-round-and-spindle-cell-sarcoma
#9
LETTER
Megan L Zilla, Dimitrios Korentzelos, Jacob Lebamoff, Melissa A Burgess, Rana Naous, Ivy John
No abstract text is available yet for this article.
April 2, 2024: Histopathology
https://read.qxmd.com/read/38556922/deceptive-learning-in-histopathology
#10
JOURNAL ARTICLE
Sahar Shahamatdar, Daryoush Saeed-Vafa, Drew Linsley, Farah Khalil, Katherine Lovinger, Lester Li, Howard T McLeod, Sohini Ramachandran, Thomas Serre
AIMS: Deep learning holds immense potential for histopathology, automating tasks that are simple for expert pathologists and revealing novel biology for tasks that were previously considered difficult or impossible to solve by eye alone. However, the extent to which the visual strategies learned by deep learning models in histopathological analysis are trustworthy or not has yet to be systematically analysed. Here, we systematically evaluate deep neural networks (DNNs) trained for histopathological analysis in order to understand if their learned strategies are trustworthy or deceptive...
March 31, 2024: Histopathology
https://read.qxmd.com/read/38530207/%C3%AE-catenin-alterations-in-testicular-leydig-cell-tumour-a-immunohistochemical-and-molecular-analysis
#11
JOURNAL ARTICLE
Yukiko Kitagawa, Dario De Biase, Costantino Ricci, Kristine M Cornejo, Michelangelo Fiorentino, Katrina Collins, Muhammad T Idrees, Maurizio Colecchia, Thomas M Ulbright, Andres Martin Acosta
BACKGROUND: Testicular Leydig cell tumours (LCTs) are the most common type of sex cord-stromal tumour in men, representing 1%-3% of all testicular neoplasms. Among testicular sex cord-stromal tumours, CTNNB1 mutations and nuclear expression of β-catenin have been typically associated with Sertoli cell tumour. Recent genomic analyses have shown that CTNNB1 variants are also identified in a subset of LCTs; however, the frequency and clinicopathologic associations of β-catenin alterations remain incompletely understood in this tumour type...
March 26, 2024: Histopathology
https://read.qxmd.com/read/38528726/papillary-thyroid-carcinoma-tall-cell-subtype-ptc-tc-and-high-grade-differentiated-thyroid-carcinoma-tall-cell-phenotype-hgdtc-tc-have-different-clinical-behaviour-a%C3%A2-retrospective-study-of-1456-patients
#12
JOURNAL ARTICLE
Ronald Ghossein, Nora Katabi, Snjezana Dogan, Ashok R Shaha, R Michael Tuttle, James A Fagin, Ian Ganly, Bin Xu
AIMS: Papillary thyroid carcinoma, tall cell subtype (PTC-TC) is a potentially aggressive histotype. The latest World Health Organisation (WHO) classification introduced a novel class of tumours; namely, high-grade differentiated thyroid carcinoma (HGDTC), characterised by elevated mitotic count and/or necrosis, which can exhibit a tall cell phenotype (HGDTC-TC). METHODS AND RESULTS: We analysed the clinical outcomes in a large retrospective cohort of 1456 consecutive thyroid carcinomas with a tall cell phenotype, including PTC-TC and HGDTC-TC...
March 25, 2024: Histopathology
https://read.qxmd.com/read/38516992/transforming-diagnostics-the-implementation-of-digital-pathology-in-clinical-laboratories
#13
REVIEW
Christine Bruce, Ioannis Prassas, Mark Mokhtar, Blaise Clarke, Elaria Youssef, Catherine Wang, George M Yousef
Digital pathology (DP) has emerged as a cutting-edge technology that promises to revolutionise diagnostics in clinical laboratories. This perspective article explores the implementation planning and considerations of DP in a single multicentre institution in Canada, the University Health Network, discussing benefits, challenges, potential implications and considerations for future adopters. We examine the transition from traditional microscopy to digital slide scanning and its impact on pathology practice, patient care and medical research...
March 22, 2024: Histopathology
https://read.qxmd.com/read/38497348/oral-epithelial-dysplasia-with-lymphocytic-immune-response-clinicopathological-characterisation-of-44-cases
#14
JOURNAL ARTICLE
Ivan J Stojanov, Joud Omari, Ibrahim Akeel, Ahmed S Sultan, Sook-Bin Woo
AIMS: Oral epithelial dysplasia (OED) often exhibits a lymphocytic/lichenoid immune response (LIR), imparting histological resemblance to lichenoid mucositis and rendering diagnosis challenging. The clinical appearances of OED and lichenoid inflammatory processes are generally divergent, presenting as well-demarcated hyperkeratotic plaques and diffuse white and/or red mucosal change with variably prominent Wickham striae, respectively. To date, clinicopathological characterisation of OED with LIR, including clinical/gross appearance, has not been depicted...
March 18, 2024: Histopathology
https://read.qxmd.com/read/38485464/prognostic-impact-of-the-iaslc-grading-system-of-lung-adenocarcinoma-a-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Fanni Hegedűs, Noémi Zombori-Tóth, Szabolcs Kiss, Tamás Lantos, Tamás Zombori
AIMS: Tumour grading is an essential part of the pathologic assessment that promotes patient management. The International Association for the Study of Lung Cancer (IASLC) proposed a grading system for non-mucinous lung adenocarcinoma in 2020. We aimed to validate the prognostic impact of this novel grading system on overall survival (OS) and recurrence-free survival (RFS) based on literature data. METHODS AND RESULTS: The review protocol was registered in PROSPERO (CRD42023396059)...
March 14, 2024: Histopathology
https://read.qxmd.com/read/38477417/accuracy-of-world-health-organisation-grade-parameters-necrosis-and-mitotic-activity-and-foci-of-vascular-invasion-in-predicting-prognosis-of-papillary-thyroid-carcinoma-a-case-control-validation-study
#16
JOURNAL ARTICLE
Moira Ragazzi, Giulia Besutti, Pamela Mancuso, Paolo Giorgi Rossi, Alessia Ciarrocchi, Benedetta Donati, Gloria Manzotti, Davide Giordano, Andrea Frasoldati, Federico Chiaruccci, Dario de de Biase, Sara Coluccelli, Thais Maloberti, Antonio De Leo, Simonetta Piana, Giovanni Tallini
AIMS: Tumour necrosis and/or increased mitoses define high-grade papillary thyroid carcinoma (PTC). It is unclear whether angioinvasion is prognostic for PTC. Cut-offs at five or more mitoses/2 mm2 and four or more angioinvasive foci have been empirically defined based upon data from all forms of aggressive non-anaplastic thyroid carcinomas. Performance of tumour necrosis, mitoses and vascular invasion in predicting distant metastases when specifically applied to PTC is undefined...
March 13, 2024: Histopathology
https://read.qxmd.com/read/38477374/prognostic-value-of-micrometric-substaging-in-pt1-bladder-cancer-patients-treated-with-en-bloc-transurethral-resection
#17
JOURNAL ARTICLE
Takafumi Yanagisawa, Shun Sato, Yasushi Hayashida, Yohei Okada, Akihiro Matsukawa, Kosuke Iwatani, Masayuki Shimoda, Hiroyuki Takahashi, Takahiro Kimura, Shahrokh F Shariat, Jun Miki
AIMS: We aimed to assess the oncological impact of micrometric extent of invasion in patients with pT1 bladder cancer (BCa) who underwent en-bloc resection for bladder tumour (ERBT). METHODS AND RESULTS: We retrospectively analysed the records and specimens of 106 pT1 high-grade BCa patients who underwent ERBT. The extent of invasion, such as depth from basal membrane, number of invasive foci, maximum width of invasive focus, muscularis mucosae invasion and infiltration pattern (pattern A: solid sheet-like, nodular or nested growth, pattern B: trabecular, small cluster or single-cell pattern) were evaluated by a single genitourinary pathologist...
March 13, 2024: Histopathology
https://read.qxmd.com/read/38477366/an-artificial-intelligence-powered-pd-l1-combined-positive-score-cps-analyser-in-urothelial-carcinoma-alleviating-interobserver-and-intersite-variability
#18
JOURNAL ARTICLE
Kyu Sang Lee, Euno Choi, Soo Ick Cho, Seonwook Park, Jeongun Ryu, Aaron Valero Puche, Minuk Ma, Jongchan Park, Wonkyung Jung, Juneyoung Ro, Sukjun Kim, Gahee Park, Sanghoon Song, Chan-Young Ock, Gheeyoung Choe, Jeong Hwan Park
AIMS: Immune checkpoint inhibitors targeting programmed death-ligand 1 (PD-L1) have shown promising clinical outcomes in urothelial carcinoma (UC). The combined positive score (CPS) quantifies PD-L1 22C3 expression in UC, but it can vary between pathologists due to the consideration of both immune and tumour cell positivity. METHODS AND RESULTS: An artificial intelligence (AI)-powered PD-L1 CPS analyser was developed using 1,275,907 cells and 6175.42 mm2 of tissue annotated by pathologists, extracted from 400 PD-L1 22C3-stained whole slide images of UC...
March 13, 2024: Histopathology
https://read.qxmd.com/read/38477341/gastric-type-glandular-lesions-of-the-female-genital-tract-excluding-the-cervix-emerging-pathological-entities
#19
REVIEW
Richard W-C Wong, Karen L Talia, W Glenn McCluggage
In the last two decades or so, a spectrum of benign, premalignant and malignant cervical glandular lesions exhibiting gastric differentiation has been described, with gastric-type adenocarcinoma representing the most common human papillomavirus (HPV)-independent cervical adenocarcinoma. More recently, limited literature has reported a variety of gastric-type glandular lesions at other sites within the female genital tract and, as in the cervix (the most common site for these lesions), a spectrum of benign, premalignant and malignant lesions has been proposed...
March 13, 2024: Histopathology
https://read.qxmd.com/read/38445509/immunohistochemical-p16-overexpression-and-rb-loss-correlate-with-high-risk-human-papillomavirus-infection-in-endocervical-adenocarcinomas
#20
JOURNAL ARTICLE
Nobuko Yasutake, Hidetaka Yamamoto, Ryosuke Kuga, Rina Jiromaru, Takahiro Hongo, Yoshihiro Katayama, Kenzo Sonoda, Hideaki Yahata, Kiyoko Kato, Yoshinao Oda
AIMS: p16 is a sensitive surrogate marker for transcriptionally active high-risk human papillomavirus (HR-HPV) infection in endocervical adenocarcinoma (ECA); however, its specificity is not perfect. METHODS AND RESULTS: We examined p16 and Rb expressions by immunohistochemistry (IHC) and the transcriptionally active HR-HPV infection by mRNA in-situ hybridisation (ISH) with histological review in 108 ECA cases. Thirteen adenocarcinomas of endometrial or equivocal origin (six endometrioid and seven serous carcinomas) were compared as the control group...
March 6, 2024: Histopathology
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