journal
https://read.qxmd.com/read/37771117/neurogenic-tumours-of-the-posterior-mediastinum-and-differential-diagnosis-considerations
#1
REVIEW
Michael A den Bakker, Annikka Weissferdt
The mediastinal compartment harbours vital organs and structures, including the heart, great vessels, major airways, and thymus. These structures are embedded in and associated with soft-tissue elements consisting of adipose and fibro-collagenous tissue in which soft-tissue tumours may develop. A detailed inventory of soft-tissue tumours that may be encountered in the mediastinum based on the WHO 2013 classification was published in 2015. In addition, several comprehensive reviews on mediastinal soft-tissue pathology are available, including reviews focusing specifically on a single tumour type...
September 28, 2023: Histopathology
https://read.qxmd.com/read/37771086/a-lipomatous-tumour-of-the-paratesticular-region-fibrosarcoma-like-lipomatous-neoplasm-or-lipoblastoma-like-tumour
#2
LETTER
Elizabeth Aliaga, Zsolt Orosz, Michael Michal, Zsombor Melegh
No abstract text is available yet for this article.
September 28, 2023: Histopathology
https://read.qxmd.com/read/37771083/atypical-cystic-hypersecretory-lesions-of-the-breast-commonly-harbour-tp53-alterations
#3
JOURNAL ARTICLE
Baris Boyraz, Dennis C Sgroi, A John Iafrate, Melinda F Lerwill
AIMS: Cystic hypersecretory lesions are rare and include atypical cystic hypersecretory hyperplasia (A-CHH) and cystic hypersecretory carcinoma in situ (CHC-IS). Despite detailed morphological descriptions, little is known about the genetic landscape of these lesions. METHODS AND RESULTS: We identified four A-CHH and three CHC-IS from 2010 to 2022. Patients ranged from 39 to 65 (median 49) years. All lesions showed characteristic cystically dilated ducts with colloid-like secretions lined by enlarged cells with hyperchromatic nuclei and at least moderate cytological atypia...
September 28, 2023: Histopathology
https://read.qxmd.com/read/37771077/role-of-gene-sequencing-in-classifying-struma-ovarii-braf-p-g469a-mutation-and-tert-promoter-alterations-favour-malignant-struma-ovarii
#4
JOURNAL ARTICLE
Sophie Neyrand, Alexis Trecourt, Jonathan Lopez, Pierre Alexandre Just, Françoise Descotes, Françoise Borson-Chazot, Isabelle Ray-Coquard, Myriam Decaussin-Petrucci, Mojgan Devouassoux-Shisheboran
AIMS: Struma ovarii (SO) are rare, accounting for 0.3-1% of ovarian tumours, and include benign and malignant lesions. In most cases, histology is not predictive of clinical outcome and prognosis. The prognosis of histologically malignant thyroid-type carcinomas can indeed be excellent, while SO, composed of normal thyroid tissue, can recur and are designated highly differentiated follicular carcinoma of the ovary. Clearer diagnostic criteria are therefore required. METHODS AND RESULTS: We retrospectively studied 31 SO using DNA and RNA sequencing with pan-cancer gene panels, including eight biologically malignant SO (BMSO) defined based on ovarian serosal or extra-ovarian dissemination at presentation or during follow-up, 10 stage IA histologically malignant SO (HMSO) with thyroid-type carcinoma morphology and 13 biologically and histologically benign SO (BSO), with none of the above-mentioned characteristics...
September 28, 2023: Histopathology
https://read.qxmd.com/read/37743102/extrauterine-epithelioid-trophoblastic-tumour-and-its-somatic-carcinoma-mimics-short-tandem-repeat-genotyping-meets-the-diagnostic-challenges
#5
JOURNAL ARTICLE
Na Niu, Zehra Ordulu, Zeybek Burak, Natalia Buza, Pei Hui
AIMS: While epithelioid trophoblastic tumour (ETT) primarily arises from the uterus, cases have been increasingly documented at extrauterine sites, originating from an ectopic gestation or presenting as a metastatic tumour, leading to the major differential diagnosis of somatic carcinoma with trophoblastic differentiation. The precise separation of a gestational trophoblastic tumour from its somatic carcinoma mimics is highly relevant and crucial for patient management and prognosis. METHODS AND RESULTS: We summarise the clinicopathological and molecular features of four challenging epithelioid malignancies presenting at extrauterine sites, with ETT as the main differential diagnosis...
September 24, 2023: Histopathology
https://read.qxmd.com/read/37743101/pleomorphic-adenoma-with-plag1-fusion-as-an-isolated-kidney-mass-lessons-learned-from-a-challenging-case
#6
JOURNAL ARTICLE
João Lobo, Markus Rechsteiner, Niels J Rupp, Helmut Ostertag, Holger Moch
No abstract text is available yet for this article.
September 24, 2023: Histopathology
https://read.qxmd.com/read/37735961/invasive-stratified-mucin-producing-carcinoma-ismc-of-the-cervix-a-clinicopathological-and-molecular-analysis-of-59-cases-with-special-emphasis-on-histogenesis-and-potential-therapeutic-targets
#7
JOURNAL ARTICLE
Yeli Yao, Yan Wang, Lei Ye, Bingjian Lu, Weiguo Lu
AIMS: This study aimed to better characterize the clinical and molecular features in invasive stratified mucin-producing carcinoma (ISMC), an uncommon aggressive subtype of endocervical adenocarcinoma (EAC). METHODS AND RESULTS: We recruited 59 ISMC for clinicopathological analysis, immunohistochemistry (n = 56), and targeted next-generation sequencing (n = 17). Our cases contained 29 pure and 30 mixed-type ISMC. Five patients developed local recurrence at 6-32 months (median: 13 months), and died of disease at 16-55 months (median: 16 months)...
September 21, 2023: Histopathology
https://read.qxmd.com/read/37726173/high-grade-vulvar-intraepithelial-neoplasia-comprehensive-characterization-and-long-term-vulvar-carcinoma-risk
#8
JOURNAL ARTICLE
Nikki B Thuijs, Marc van Beurden, Sylvia Duin, Daniëlle A M Heideman, Johannes Berkhof, Renske D M Steenbergen, Maaike C G Bleeker
AIMS: Adequate diagnosis of human papillomavirus (HPV)-associated high-grade squamous intraepithelial lesion (HSIL) and HPV-independent vulvar intraepithelial neoplasia (VIN) is essential but can be challenging. We comprehensively characterized a large population-based series of vulvar lesions, originally reported as high-grade VIN, and assessed the cancer risk. METHODS AND RESULTS: Baseline high-grade VIN of 751 patients were categorized by histopathological reassessment, integrating the results of immunohistochemistry (p16INK4a , p53, Ki-67) and HPV DNA testing...
September 19, 2023: Histopathology
https://read.qxmd.com/read/37722860/dataset-for-reporting-of-thymic-epithelial-tumours-recommendations-from-the-international-collaboration-on-cancer-reporting-iccr
#9
JOURNAL ARTICLE
Anja C Roden, Meagan Judge, Michael A den Bakker, Wentao Fang, Deepali Jain, Alexander Marx, Andre L Moreira, Arun Rajan, Philipp Stroebel, Malgorzata Szolkowska, Wendy A Cooper
AIMS: Thymic epithelial tumours (TET), including thymomas and thymic carcinomas and thymic neuroendocrine neoplasms, are malignant neoplasms that can be associated with morbidity and mortality. Recently, an updated version of the World Health Organization (WHO) Classification of Thoracic Tumours 5th Edition, 2021 has been released, which included various changes to the classification of these neoplasms. In addition, in 2017 the Union for International Cancer Control (UICC) / American Joint Committee on Cancer (AJCC) published the 8th Edition Staging Manual which, for the first time, includes a TNM staging that is applicable to thymomas, thymic carcinomas, and thymic neuroendocrine neoplasms...
September 18, 2023: Histopathology
https://read.qxmd.com/read/37706251/molecular-characterisation-of-tumours-of-the-lacrimal-apparatus
#10
JOURNAL ARTICLE
Roseline Vibert, Joanna Cyrta, Elodie Girard, Sophie Vacher, Célia Dupain, Samantha Antonio, Jennifer Wong, Sylvain Baulande, Juliana Monteiro Ferras De Sousa, Anne Vincent-Salomon, Julien Masliah-Planchon, Nicolas Girard, Christophe Le Tourneau, Maud Kamal, Ivan Bièche
AIMS: Malignant tumours of the lacrimal apparatus are rare and frequently show a poor prognosis, with no clear therapeutic standards. Characterisation of the genetic landscape of these rare tumours is sparse, and therefore therapeutics generally follow those of their common salivary gland counterparts. To further clarify the pathophysiology and discover potential therapeutic targets, we investigated the genetic landscape of eight tumours of the lacrimal apparatus. METHODS AND RESULTS: DNA and RNA sequencing were performed to identify genetic mutations and gene fusions...
September 14, 2023: Histopathology
https://read.qxmd.com/read/37706239/ki67-proliferation-index-in-medullary-thyroid-carcinoma-a%C3%A2-comparative-study-of-multiple-counting-methods-and-validation-of-image-analysis-and-deep-learning-platforms
#11
JOURNAL ARTICLE
Saad Nadeem, Matthew G Hanna, Kartik Viswanathan, Joseph Marino, Mahsa Ahadi, Bayan Alzumaili, Mohamed-Amine Bani, Federico Chiarucci, Angela Chou, Antonio De Leo, Talia L Fuchs, Daniel J Lubin, Catherine Luxford, Kelly Magliocca, Germán Martinez, Qiuying Shi, Stan Sidhu, Abir Al Ghuzlan, Anthony J Gill, Giovanni Tallini, Ronald Ghossein, Bin Xu
AIMS: The International Medullary Thyroid Carcinoma Grading System, introduced in 2022, mandates evaluation of the Ki67 proliferation index to assign a histological grade for medullary thyroid carcinoma. However, manual counting remains a tedious and time-consuming task. METHODS AND RESULTS: We aimed to evaluate the performance of three other counting techniques for the Ki67 index, eyeballing by a trained experienced investigator, a machine learning-based deep learning algorithm (DeepLIIF) and an image analysis software with internal thresholding compared to the gold standard manual counting in a large cohort of 260 primarily resected medullary thyroid carcinoma...
September 14, 2023: Histopathology
https://read.qxmd.com/read/37706238/malignant-phyllodes-tumour-with-lymph-node-metastasis-a-diagnostic-conundrum-resolved-by-next-generation-dna-sequencing
#12
LETTER
Christopher J Schwartz, Gregor Krings, Yunn-Yi Chen
Both flower orientation and corolla length serve as reproductive barriers between Erica shannonea and Erica ampullaceal, which might have played an important role in their pollinator-driven divergence.
September 14, 2023: Histopathology
https://read.qxmd.com/read/37694812/recent-developments-in-the-pathology-of-primary-pulmonary-salivary-gland-type-tumours
#13
REVIEW
Julia R Naso, Anja C Roden
Primary pulmonary salivary gland-type tumours are rare neoplasms that are thought to arise from seromucinous glands that are located in the submucosa of large airways. These neoplasms have clinical and pathologic features that are distinct from other pulmonary neoplasms. The majority of primary pulmonary salivary gland-type tumours are malignant, with the most common entities being mucoepidermoid carcinoma, adenoid cystic carcinoma, and epithelial-myoepithelial carcinoma. Less commonly seen are myoepithelial carcinoma, hyalinizing clear cell carcinoma, acinic cell carcinoma, secretory carcinoma, salivary duct carcinoma, intraductal carcinoma, and polymorphous adenocarcinoma...
September 11, 2023: Histopathology
https://read.qxmd.com/read/37694811/new-developments-in-mesothelial-pathology
#14
REVIEW
Andrew Churg
This review article examines some new and some problem areas in mesothelial pathology, four of which are discussed, as follows. (1) The concept of mesothelioma in situ: this lesion is defined as a single layer of bland mesothelial cells without evidence of invasion, but that have lost BAP1 and/or MTAP by immunohistochemistry. Benign reactions can exactly mimic mesothelioma in situ, but a hint to the correct diagnosis is a story of recurrent pleural effusions/ascites of unknown aetiology without radiological or direct visual evidence of tumour...
September 11, 2023: Histopathology
https://read.qxmd.com/read/37691389/mesenchymal-tumours-of-the-pleura-review-and-update
#15
REVIEW
Vilasinee Rerkpichaisuth, Yin P Hung
Primary mesenchymal tumours of the pleura are uncommon and can be diagnostically challenging due to their overlapping histopathologic and immunophenotypic features. Herein we discuss selected mesenchymal tumours of the pleura, including solitary fibrous tumour, calcifying fibrous tumour, desmoid fibromatosis, synovial sarcoma, schwannoma, malignant peripheral nerve sheath tumour, inflammatory myofibroblastic tumour, follicular dendritic cell sarcoma, epithelioid hemangioendothelioma, and desmoplastic small round cell tumour...
September 10, 2023: Histopathology
https://read.qxmd.com/read/37691383/what-s-new-in-benign-lung-tumours
#16
REVIEW
Jennifer M Boland
While lung cancer is one of the most common malignancies routinely encountered by pathologists, benign pulmonary neoplasms are quite rare. However, it is important for pathologists to be familiar with the typical diagnostic features of benign lung tumors to avoid confusing them with malignant morphological mimics. There have also been intriguing discoveries in the genetics of benign pulmonary neoplasms in the past decade. This review will cover several of the most common benign lung tumors, including the diagnostic categories of pulmonary adenomas, bronchial papillomas, and benign mesenchymal tumors, with discussion of the current classification, differential diagnosis, and current knowledge regarding genetic drivers...
September 10, 2023: Histopathology
https://read.qxmd.com/read/37680034/novel-ewsr1-gfi1b-gene-fusion-in-angiofibroma-of-soft-tissue
#17
JOURNAL ARTICLE
Albert J H Suurmeijer, Arjen H G Cleven, Cristina R Antonescu, Lauren A Duckworth, Karen J Fritchie, Steven D Billings, Josephine K Dermawan
AIMS: Angiofibroma of soft tissue is a benign soft tissue tumour characterised by bland spindle cells and a distinct branching vascular network. The majority of soft tissue angiofibromas harbour AHRR::NCOA2 gene fusions. Here we present three cases of EWSR1::GFI1B-fused soft tissue tumours that are morphologically most reminiscent of soft tissue angiofibroma. METHODS AND RESULTS: All three cases presented in male patients with an age range of 35-78 years (median = 54 years)...
September 7, 2023: Histopathology
https://read.qxmd.com/read/37680023/abcc2-brush-border-expression-predicts-outcome-in-papillary-renal-cell-carcinoma-a-multi-institutional-study-of-254-cases
#18
JOURNAL ARTICLE
Vincent Francis Castillo, Mehdi Masoomian, Kiril Trpkov, Michelle Downes, Fadi Brimo, Theodorus van der Kwast, George M Yousef, Abraam Zakhary, Fabio Rotondo, Gina Saad, Vy-Nhan Nguyen, Wondwossen Kidanewold, Catherine Streutker, Corwyn Rowsell, Malek Hamdani, Rola M Saleeb
AIMS: Papillary renal cell carcinoma (PRCC) histologic subtyping is no longer recommended in the 2022 WHO classification. Currently, WHO/ISUP nucleolar grade is the only accepted prognostic histologic parameter for PRCC. ABCC2, a renal drug transporter, has been shown to significantly predict outcomes in PRCC. In this study we evaluated the prognostic significance of ABCC2 IHC staining patterns in a large, multi-institutional PRCC cohort and assessed the association of these patterns with ABCC2 mRNA expression...
September 7, 2023: Histopathology
https://read.qxmd.com/read/37679051/tsc2-inactivation-low-mutation-burden-and-high-macrophage-infiltration-characterise-hepatic-angiomyolipomas
#19
JOURNAL ARTICLE
Krinio Giannikou, Katarzyna Klonowska, Junko Tsuji, Shulin Wu, Zachary Zhu, Clemens K Probst, Katrina Z Kao, Chin-Lee Wu, Scott Rodig, Adrian Marino-Enriquez, Yoh Zen, Inga-Marie Schaefer, David J Kwiatkowski
AIMS: Although TSC1 or TSC2 inactivating mutations that lead to mTORC1 hyperactivation have been reported in hepatic angiomyolipomas (hAML), the role of other somatic genetic events that may contribute to hAML development is unknown. There are also limited data regarding the tumour microenvironment (TME) of hAML. The aim of the present study was to identify other somatic events in genomic level and changes in TME that contribute to tumorigenesis in hAML. METHODS AND RESULTS: In this study, we performed exome sequencing in nine sporadic hAML tumours and deep-coverage targeted sequencing for TSC2 in three additional hAML...
September 7, 2023: Histopathology
https://read.qxmd.com/read/37661783/metallothionein-a-game-changer-in-histopathological-diagnosis-of-wilson-disease
#20
JOURNAL ARTICLE
Hendrik Wiethoff, Isabelle Mohr, Alexander Fichtner, Uta Merle, Peter Schirmacher, Karl H Weiss, Thomas Longerich
AIMS: Wilson disease (WD) is a genetic disorder of copper metabolism caused by mutations in the ATP7B gene. Toxic copper accumulation leads to hepatic, neurologic, and psychiatric disorders with variable presentation. Metallothionein (MT) immunohistochemistry was proposed as a diagnostic marker. METHODS: MT immunohistochemistry was performed on liver specimens of WD patients (n = 64) and control cases (n = 160) including acute liver failure, steatotic liver disease, autoimmune hepatitis, normal liver, primary biliary cholangitis, primary and secondary sclerosing cholangitis, and progressive familial intrahepatic cholestasis...
September 4, 2023: Histopathology
journal
journal
20117
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.