Gilbert E Cramer, Marc A Brouwer
No abstract text is available yet for this article.
July 10, 2020: Heart
Pawel Dimitrow, Renata Rajtar-Salwa, Tomasz Tokarek
No abstract text is available yet for this article.
July 10, 2020: Heart
Todd Dardas, Michael P Dorsch
No abstract text is available yet for this article.
July 9, 2020: Heart
June-Sung Kim, Youn-Jung Kim, Muyeol Kim, Seung Mok Ryoo, Won Young Kim
OBJECTIVE: Sepsis-induced myocardial dysfunction (SIMD) can involve both the left and right ventricles. However, the characteristics and outcomes across various manifestations of SIMD remain unknown. METHODS: This was a retrospective cohort study using a prospective registry of septic shock from January 2011 and April 2017. Patients with clinically presumed cardiac dysfunction underwent echocardiography within 72 hours after admission and were enrolled (n=778)...
July 8, 2020: Heart
Nicolas Perrot, Sébastien Thériault, Sidwell Rigade, Hao Yu Chen, Christian Dina, Andreas Martinsson, S Matthijs Boekholdt, Romain Capoulade, Thierry Le Tourneau, David Messika-Zeitoun, James C Engert, Nicholas J Wareham, Marie-Annick Clavel, Philippe Pibarot, J Gustav Smith, Jean Jacques Schott, Patrick Mathieu, Yohan Bossé, George Thanassoulis, Benoit J Arsenault
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been shown to predict calcific aortic valve stenosis (CAVS) outcomes. Our objective was to test the association between plasma Lp-PLA2 activity and genetically elevated Lp-PLA2 mass/activity with CAVS in humans. METHODS AND RESULTS: Lp-PLA2 activity was measured in 890 patients undergoing cardiac surgery, including 476 patients undergoing aortic valve replacement for CAVS and 414 control patients undergoing coronary artery bypass grafting...
July 7, 2020: Heart
Kang H Zheng, Marc R Dweck
No abstract text is available yet for this article.
July 7, 2020: Heart: Official Journal of the British Cardiac Society
Luigi P Badano, Karima Addetia, Gianluca Pontone, Camilla Torlasco, Roberto M Lang, Gianfranco Parati, Denisa Muraru
Right ventricular (RV) size and function are important predictors of cardiovascular morbidity and mortality in patients with various conditions. However, non-invasive assessment of the RV is a challenging task due to its complex anatomy and location in the chest. Although conventional echocardiography is widely used, its limitations in RV assessment are well recognised. New techniques such as three-dimensional and speckle tracking echocardiography have overcome the limitations of conventional echocardiography allowing a comprehensive, quantitative assessment of RV geometry and function without geometric assumptions...
July 3, 2020: Heart: Official Journal of the British Cardiac Society
Louise Feldborg Lyckhage, Morten Lock Hansen, Jens Christian Toft, Susanne Lis Larsen, Bente Brendorp, Ari Mohammad Ali, Troels Wienecke
BACKGROUND AND PURPOSE: The diagnostic benefit of using continuous ECG (cECG) for poststroke atrial fibrillation (AF) screening in a primary care setting is unclear. We aimed to assess the diagnostic yield from screening patients who previously had a stroke with a 7-day Holter monitor. METHODS: Patients older than 49 years, naive to AF, with an ischaemic stroke over 1 year before enrolment were included. In a primary care setting, all patients were screened for AF using pulse palpation, 12-lead ECG and 7-day Holter monitoring...
July 3, 2020: Heart: Official Journal of the British Cardiac Society
Verónica Cabanas-Sánchez, Enrique G Artero, Carl J Lavie, Sara Higueras-Fresnillo, Esther García-Esquinas, Kabir P Sadarangani, Rosario Ortolá, Fernando Rodríguez-Artalejo, David Martínez-Gómez
OBJECTIVE: To estimate the incidence of major biological cardiovascular disease (CVD) risk factors in adults using non-exercise estimated cardiorespiratory fitness (eCRF). METHODS: 200 039 healthy people (99 957 women), aged ≥18 years (38.5±12.1 years) from the Taiwan MJ Cohort. eCRF was estimated with validated algorithms. Biological CVD risk factors, including hypertension (HTN), hypercholesterolemia, atherogenic dyslipidaemia, type 2 diabetes mellitus (T2DM) and systemic inflammation, were assessed by standardised physical examinations and laboratory tests...
July 2, 2020: Heart: Official Journal of the British Cardiac Society
Maria Elena Flacco, Cecilia Acuti Martellucci, Francesca Bravi, Giustino Parruti, Rosaria Cappadona, Alfonso Mascitelli, Roberto Manfredini, Lorenzo G Mantovani, Lamberto Manzoli
OBJECTIVE: It has been hypothesised that the use of ACE inhibitors and angiotensin receptor blockers (ARBs) might either increase or reduce the risk of severe or lethal COVID-19. The findings from the available observational studies varied, and summary estimates are urgently needed to elucidate whether these drugs should be suspended during the pandemic, or patients and physicians should be definitely reassured. This meta-analysis of adjusted observational data aimed to summarise the existing evidence on the association between these medications and severe/lethal COVID-19...
July 1, 2020: Heart: Official Journal of the British Cardiac Society
Iris M van Hagen, Jolien W Roos-Hesselink
No abstract text is available yet for this article.
July 1, 2020: Heart: Official Journal of the British Cardiac Society
Massimo Imazio, Alessandro Andreis, Antonio Brucato, Yehuda Adler, Gaetano Maria De Ferrari
Colchicine is an ancient drug, traditionally used for the treatment and prevention of gouty attacks; it has become standard of treatment for pericarditis with a potential role in the treatment of coronary artery disease. Atherosclerotic plaque formation, progression, destabilisation and rupture are influenced by active proinflammatory cytokines interleukin (IL)-1β and IL-18 that are generated in the active forms by inflammasomes, which are cytosolic multiprotein oligomers of the innate immune system responsible for the activation of inflammatory responses...
July 1, 2020: Heart: Official Journal of the British Cardiac Society
Jyoti Baghel, Anish Keepanasseril, Ajith Ananthakrishna Pillai, Nivedita Mondal, Yavanasuriya Jeganathan, Pankaj Kundra
OBJECTIVE: To assess the incidence of adverse cardiac events in pregnant women with rheumatic valvular heart disease (RHD) and to derive a clinical risk scoring for predicting it. METHODS: This is an observational study involving pregnant women with RHD, attending a tertiary centre in south India. Data regarding obstetric history, medical history, maternal complications and perinatal outcome till discharge were collected. Eight-hundred and twenty pregnancies among 681 women were included in the analysis...
June 29, 2020: Heart: Official Journal of the British Cardiac Society
Kyle Geurink, DaJuanicia Holmes, Michael D Ezekowitz, Karen Pieper, Gregg Fonarow, Peter R Kowey, James A Reiffel, Daniel E Singer, James Freeman, Bernard J Gersh, Kenneth W Mahaffey, Elaine M Hylek, Gerald Naccarelli, Jonathan P Piccini, Eric D Peterson, Sean D Pokorney
BACKGROUND: Cardioversion is common among patients with atrial fibrillation (AF). We hypothesised that novel oral anticoagulants (NOAC) used in clinical practice resulted in similar rates of stroke compared with vitamin K antagonists (VKA) for cardioversion. METHODS: Using the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II, patients with AF who had a cardioversion, follow-up data and an AF diagnosis within 6 months of enrolment were identified retrospectively...
June 26, 2020: Heart: Official Journal of the British Cardiac Society
Kazem Rahimi, Milad Nazarzadeh, Ana-Catarina Pinho-Gomes, Mark Woodward, Gholamreza Salimi-Khorshidi, Toshiaki Ohkuma, Raymond Fitzpatrick, Lionel Tarassenko, Mike Denis, John Cleland
OBJECTIVES: We aimed to investigate whether digital home monitoring with centralised specialist support for remote management of heart failure (HF) is more effective in improving medical therapy and patients' quality of life than digital home monitoring alone. METHODS: In a two-armed partially blinded parallel randomised controlled trial, seven sites in the UK recruited a total of 202 high-risk patients with HF (71.3 years SD 11.1; left ventricular ejection fraction 32...
June 24, 2020: Heart: Official Journal of the British Cardiac Society
Xuejun Yin, Yibo He, Jing Zhang, Feier Song, Jin Liu, Guoli Sun, Yan Liang, Jianfeng Ye, Yunzhao Hu, Mingcai Song, Cong Chen, Qingbo Xu, Ning Tan, Jiyan Chen, Yong Liu, Hueiming Liu, Maoyi Tian
OBJECTIVE: This study aims to understand the current ST elevated myocardial infarction (STEMI) treatment process in Guangdong Province and explore patient-level and system-level barriers associated with delay in STEMI treatment, so as to provide recommendations for improvement. METHODS: This is a qualitative study. Data were collected using semistructured, face-to-face individual interviews from April 2018 to January 2019. Participants included patients with STEMI, cardiologists and nurses from hospitals, emergency department doctors, primary healthcare providers, local health governors, and coordinators at the emergency medical system (EMS)...
June 24, 2020: Heart
Andreas Capiau, Els Mehuys, Inge Van Tongelen, Thierry Christiaens, An De Sutter, Stephane Steurbaut, Souad Moudallel, Silas Rydant, Bernard Vrijens, Tine L M de Backer, Koen Boussery
OBJECTIVE: This study aimed to assess implementation adherence (how well the patient's actual intake matches the prescribed dosing regimen) to non-vitamin K antagonist oral anticoagulants (NOACs) and to explore experiences with and beliefs about NOACs in a real-world sample of long-term NOAC users. METHODS: A cross-sectional observational study was conducted in home-dwelling adults who started taking a NOAC at least 1 year prior to inclusion. Pharmacy dispensing data were used to calculate the Medication Possession Ratio (MPR)...
June 23, 2020: Heart
Claudia Marini, Gabriele Fragasso, Leonardo Italia, Hamayak Sisakian, Vincenzo Tufaro, Giacomo Ingallina, Stefano Stella, Francesco Ancona, Ferdinando Loiacono, Pasquale Innelli, Marco Fabio Costantino, Laura Sahakyan, Sirvard Gabrielyan, Mariam Avetisyan, Alberto Margonato, Eustachio Agricola
OBJECTIVE: Pulmonary congestion is the main cause of hospital admission in patients with heart failure (HF). Lung ultrasound (LUS) is a useful tool to identify subclinical pulmonary congestion. We evaluated the usefulness of LUS in addition to physical examination (PE) in the management of outpatients with HF. METHODS: In this randomised multicentre unblinded study, patients with chronic HF and optimised medical therapy were randomised in two groups: 'PE+LUS' group undergoing PE and LUS and 'PE only' group...
June 22, 2020: Heart: Official Journal of the British Cardiac Society
Jason M Tarkin, Andrej Ćorović, Christopher Wall, Deepa Gopalan, James Hf Rudd
Positron emission tomography (PET) imaging is useful in cardiovascular disease across several areas, from assessment of myocardial perfusion and viability, to highlighting atherosclerotic plaque activity and measuring the extent of cardiac innervation in heart failure. Other important roles of PET have emerged in prosthetic valve endocarditis, implanted device infection, infiltrative cardiomyopathies, aortic stenosis and cardio-oncology. Advances in scanner technology, including hybrid PET/MRI and total body PET imaging, as well as the development of novel PET tracers and cardiac-specific postprocessing techniques using artificial intelligence will undoubtedly continue to progress the field...
June 22, 2020: Heart: Official Journal of the British Cardiac Society
Muhummad Sohaib Nazir, Tarun K Mittal, Jonathan Weir-McCall, Koen Nieman, Keith Channon, Edward D Nicol
CT-derived fractional flow reserve (CT-FFR) uses computational fluid dynamics to derive non-invasive FFR to determine the haemodynamic significance of coronary artery lesions. Studies have demonstrated good diagnostic accuracy of CT-FFR and reassuring short-term clinical outcome data.As a prerequisite, high-quality CT coronary angiography (CTCA) images are required with good heart rate control and pre-treatment with glyceryl trinitrate, which would otherwise render CTCA as unsuitable for CT-FFR. CT-FFR can determine the functional significance of CAD lesions, and there are supportive data for its use in clinical decision-making...
June 19, 2020: Heart: Official Journal of the British Cardiac Society
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