journal
https://read.qxmd.com/read/33833070/predictive-models-for-cardiovascular-and-kidney-outcomes-in-patients-with-type-2-diabetes-systematic-review-and-meta-analyses
#1
Tayler A Buchan, Abdullah Malik, Cynthia Chan, Jason Chambers, Yujin Suk, Jie Wei Zhu, Fang Zhou Ge, Le Ming Huang, Lina Abril Vargas, Qiukui Hao, Sheyu Li, Reem A Mustafa, Per Olav Vandvik, Gordon Guyatt, Farid Foroutan
OBJECTIVE: To inform a clinical practice guideline (BMJ Rapid Recommendations) considering sodium glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists for treatment of adults with type 2 diabetes, we summarised the available evidence regarding the performance of validated risk models on cardiovascular and kidney outcomes in these patients. METHODS: We systematically searched bibliographic databases in January 2020 to identify observational studies evaluating risk models for all-cause and cardiovascular mortality, heart failure (HF) hospitalisations, end-stage kidney disease (ESKD), myocardial infarction (MI) and ischaemic stroke in ambulatory adults with type 2 diabetes...
April 8, 2021: Heart
https://read.qxmd.com/read/33833069/prognostic-implications-of-left-atrial-dilation-in-aortic-regurgitation-due-to-bicuspid-aortic-valve
#2
Steele C Butcher, Federico Fortuni, William Kong, E Mara Vollema, Francesca Prevedello, Rebecca Perry, Arnold Chin Tse Ng, Kian Keong Poh, Ana G Almeida, Ariana González-Gómez, Mylène Shen, Tiong-Cheng Yeo, Miriam Shanks, Bogdan A Popescu, Laura Galian-Gay, Marcin Fijalkowski, Michael Liang, Edgar Tay, Nina Ajmone Marsan, Joseph B Selvanayagam, Fausto J Pinto, José Zamorano, Philippe Pibarot, Arturo Evangelista, Jeroen J Bax, Victoria Delgado
OBJECTIVE: To investigate the prognostic value of left atrial volume index (LAVI) in patients with moderate to severe aortic regurgitation (AR) and bicuspid aortic valve (BAV). METHODS: 554 individuals (45 (IQR 33-57) years, 80% male) with BAV and moderate or severe AR were selected from an international, multicentre registry. The association between LAVI and the combined endpoint of all-cause mortality or aortic valve surgery was investigated with Cox proportional hazard regression analyses...
April 8, 2021: Heart
https://read.qxmd.com/read/33820757/optimising-cardiovascular-care-of-patients-with-multiple-myeloma
#3
REVIEW
Marta Fontes Oliveira, Willeke R Naaktgeboren, Alina Hua, Arjun K Ghosh, Heather Oakervee, Simon Hallam, Charlotte Manisty
Multiple myeloma (MM) is the third most common haematological malignancy, with increasing prevalence over recent years. Advances in therapy have improved survival, changing the clinical course of MM into a chronic condition and meaning that management of comorbidities is fundamental to improve clinical outcomes. Cardiovascular (CV) events affect up to 7.5% of individuals with MM, due to a combination of patient, disease and treatment-related factors and adversely impact survival. MM typically affects older people, many with pre-existing CV risk factors or established CV disease, and the disease itself can cause renal impairment, anaemia and hyperviscosity, which exacerabate these further...
April 5, 2021: Heart
https://read.qxmd.com/read/33811131/association-of-cardiovascular-health-and-incident-atrial-fibrillation-in-elderly-population
#4
Jae-Hyuk Lee, Pil-Sung Yang, Hee Tae Yu, Tae-Hoon Kim, Eunsun Jang, Jae-Sun Uhm, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
OBJECTIVE: To evaluate whether baseline and changes in cardiovascular health (CVH) were related to incident atrial fibrillation (AF) risk in the elderly population. METHODS: From the Korea National Health Insurance Service-Senior cohort, we included 208 598 participants without prior AF (median age: 70 (IQR 66-74) years; 90 916 (43.6%) men) who underwent national health check-ups between 1 January 2005 and 31 December 2012. Using the six metrics of the American Heart Association, participants were categorised as having low, moderate and high CVH...
April 2, 2021: Heart
https://read.qxmd.com/read/33811130/axial-flow-ventricular-assist-devices-in-cardiogenic-shock-complicating-acute-myocardial-infarction
#5
REVIEW
Laurna McGovern, John Cosgrave
Cardiogenic shock (CS) remains the leading cause of death in patients hospitalised with acute myocardial infarction with mortality as high as 40%-50% prior to hospital discharge. The failure of inotropic therapy to maintain adequate perfusion and to prevent irreversible end-organ failure has led to attempts to improve outcomes by mechanical circulatory support (MCS) devices. Axial flow ventricular assist devices, namely Impella, are an attractive therapeutic option due to their positive haemodynamic benefits and ease of use...
April 2, 2021: Heart
https://read.qxmd.com/read/33795382/addition-of-cystatin-c-predicts-cardiovascular-death-better-than-creatinine-in-intensive-care
#6
Johanna Helmersson-Karlqvist, Miklos Lipcsey, Johan Ärnlöv, Max Bell, Bo Ravn, Alain Dardashti, Anders Larsson
OBJECTIVE: Decreased kidney function increases cardiovascular risk and predicts poor survival. Estimated glomerular filtration rate (eGFR) by creatinine may theoretically be less accurate in the critically ill. This observational study compares long-term cardiovascular mortality risk by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation; Caucasian, Asian, paediatric and adult cohort (CAPA) cystatin C equation and the CKD-EPI combined creatinine/cystatin C equation...
April 1, 2021: Heart
https://read.qxmd.com/read/33795381/racial-ethnic-and-socioeconomic-disparities-in-patients-undergoing-left-atrial-appendage-closure
#7
Robbie Sparrow, Shubrandu Sanjoy, Yun-Hee Choi, Islam Y Elgendy, Hani Jneid, Pedro A Villablanca, David R Holmes, Ashish Pershad, Chadi Alraies, Luciano A Sposato, Mamas A Mamas, Rodrigo Bagur
OBJECTIVE: This manuscript aims to explore the impact of race/ethnicity and socioeconomic status on in-hospital complication rates after left atrial appendage closure (LAAC). METHODS: The US National Inpatient Sample was used to identify hospitalisations for LAAC between 1 October 2015 to 31 December 2018. These patients were stratified by race/ethnicity and quartiles of median neighbourhood income. The primary outcome was the occurrence of in-hospital major adverse events, defined as a composite of postprocedural bleeding, cardiac and vascular complications, acute kidney injury and ischaemic stroke...
April 1, 2021: Heart
https://read.qxmd.com/read/33795380/survival-after-surgical-aortic-valve-replacement-in-patients-with-bicuspid-aortic-valve-disease
#8
EDITORIAL
Marjan Jahangiri
No abstract text is available yet for this article.
April 1, 2021: Heart
https://read.qxmd.com/read/33795379/intensive-low-density-lipoprotein-cholesterol-lowering-in-cardiovascular-disease-prevention-opportunities-and-challenges
#9
REVIEW
Chris Packard, M John Chapman, Mahendra Sibartie, Ulrich Laufs, Luis Masana
Elevated levels of low-density lipoprotein cholesterol (LDL-C) are associated with increased risk of coronary heart disease and stroke. Guidelines for the management of dyslipidaemia from the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) were updated in late 2019 in light of recent intervention trials involving the use of innovative lipid-lowering agents in combination with statins. The new guidelines advocate achieving very low LDL-C levels in individuals at highest risk, within the paradigm of 'lower is better'...
April 1, 2021: Heart
https://read.qxmd.com/read/33789973/telomere-length-is-independently-associated-with-all-cause-mortality-in-chronic-heart-failure
#10
Simon P R Romaine, Matthew Denniff, Veryan Codd, Mintu Nath, Andrea Koekemoer, Stefan D Anker, John G Cleland, Gerasimos Filippatos, Daniel Levin, Marco Metra, Ify R Mordi, Wouter Ouwerkerk, Jozine M Ter Maaten, Dirk J van Veldhuisen, Faiez Zannad, Leong L Ng, Pim van der Harst, Chim C Lang, Adriaan A Voors, Christopher P Nelson, Nilesh J Samani
OBJECTIVE: Patients with heart failure have shorter mean leucocyte telomere length (LTL), a marker of biological age, compared with healthy subjects, but it is unclear whether this is of prognostic significance. We therefore sought to determine whether LTL is associated with outcomes in patients with heart failure. METHODS: We measured LTL in patients with heart failure from the BIOSTAT-CHF Index (n=2260) and BIOSTAT-CHF Tayside (n=1413) cohorts. Cox proportional hazards analyses were performed individually in each cohort and the estimates combined using meta-analysis...
March 31, 2021: Heart
https://read.qxmd.com/read/33789972/contemporary-management-of-calcified-coronary-lesions
#11
Emanuele Barbato
No abstract text is available yet for this article.
March 31, 2021: Heart
https://read.qxmd.com/read/33766986/regional-variation-in-cardiovascular-magnetic-resonance-service-delivery-across-the-uk
#12
Niall G Keenan, Gabriella Captur, Gerry P McCann, Colin Berry, Saul G Myerson, Timothy Fairbairn, Lucy Hudsmith, Declan P O'Regan, Mark Westwood, John P Greenwood
OBJECTIVES: To examine service provision in cardiovascular magnetic resonance (CMR) in the UK. Equitable access to diagnostic imaging is important in healthcare. CMR is widely available in the UK, but there may be regional variations. METHODS: An electronic survey was sent by the British Society of CMR to the service leads of all CMR units in the UK in 2019 requesting data from 2017 and 2018. Responses were analysed by region and interpreted alongside population statistics...
March 25, 2021: Heart
https://read.qxmd.com/read/33766985/risk-of-left-atrial-appendage-thrombus-and-stroke-in-patients-with-atrial-fibrillation-and-mitral-regurgitation
#13
Rowlens Melduni, Vuyisile T Nkomo, Waldemar Wysokinski, Bernard J Gersh, Abhishek Deshmukh, Ratnasari Padang, Eddie L Greene, Jae K Oh, Hon-Chi Lee
OBJECTIVE: To investigate the association of mitral regurgitation (MR) on thromboembolic risk of patients with non-valvular atrial fibrillation (NVAF) undergoing transoesophageal echocardiography (TEE)-guided cardioversion. METHODS: Data for consecutive patients who underwent TEE-guided cardioversion for NVAF between 2000 and 2012 were analysed. MR severity was assessed by Doppler echocardiography and classified as ≤mild, moderate or severe. Left atrial appendage emptying velocities were averaged for five consecutive cycles...
March 25, 2021: Heart
https://read.qxmd.com/read/33758008/p2y12-inhibitor-monotherapy-after-coronary-stenting-according-to-type-of-p2y12-inhibitor
#14
Juwon Kim, Woo Jin Jang, Wang Soo Lee, Ki Hong Choi, Joo Myung Lee, Taek Kyu Park, Jeong Hoon Yang, Jin-Ho Choi, Young Bin Song, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Sang Hoon Lee, Ju-Hyeon Oh, Woo Jung Chun, Yong Hwan Park, Eul-Soon Im, Jin-Ok Jeong, Byung Ryul Cho, Seok Kyu Oh, Kyeong Ho Yun, Deok-Kyu Cho, Jong-Young Lee, Young-Youp Koh, Jang-Whan Bae, Jae Woong Choi, Hyuck Jun Yoon, Seung Uk Lee, Jang Hyun Cho, Woong Gil Choi, Seung-Woon Rha, Joo-Yong Hahn
OBJECTIVE: To compare P2Y12 inhibitor monotherapy after 3-month dual antiplatelet therapy (DAPT) with 12-month DAPT according to the type of P2Y12 inhibitor in patients undergoing percutaneous coronary intervention (PCI). METHODS: The Smart Angioplasty Research Team: Comparison Between P2Y12 Antagonist Monotherapy vs Dual Antiplatelet Therapy in Patients Undergoing Implantation of Coronary Drug-Eluting Stents (SMART-CHOICE) randomised trial compared 3-month DAPT followed by P2Y12 inhibitor monotherapy with 12-month DAPT...
March 23, 2021: Heart
https://read.qxmd.com/read/33753450/correction-animation-supported-consent-for-urgent-angiography-and-angioplasty-a-service-improvement-initiative
#15
(no author information available yet)
No abstract text is available yet for this article.
March 22, 2021: Heart
https://read.qxmd.com/read/33741579/ticagrelor-versus-prasugrel-for-pci-managed-myocardial-infarction-the-battle-of-the-giants-continues
#16
EDITORIAL
Robert F Storey
No abstract text is available yet for this article.
March 19, 2021: Heart
https://read.qxmd.com/read/33741578/management-considerations-in-the-adult-with-surgically-modified-d-transposition-of-the-great-arteries
#17
REVIEW
Lasya Gaur, Ari Cedars, Gerhard Paul Diller, Shelby Kutty, Stefan Orwat
Dextro-transposition of the great arteries (D-TGA) has undergone a significant evolution in surgical repair, leading to survivors with vastly different postsurgical anatomy which in turn guides their long-term cardiovascular morbidity and mortality. Arterial switch repair survivors are limited by a right ventricle in the systemic arterial position, arrhythmia and atrial baffles prone to obstruction or leak. Functional assessment of the systemic right ventricle is complex, requiring multimodality imaging to include specialised echocardiography and cross-sectional imaging (MRI and CT)...
March 19, 2021: Heart
https://read.qxmd.com/read/33741577/women-in-cardiology-no-progress-in-the-pace-of-change
#18
EDITORIAL
Sonya V Babu-Narayan, Simon Ray
No abstract text is available yet for this article.
March 19, 2021: Heart
https://read.qxmd.com/read/33741576/atrioventricular-valve-regurgitation-still-a-long-road-ahead
#19
EDITORIAL
Bouleti Claire, Bernard Iung
No abstract text is available yet for this article.
March 19, 2021: Heart
https://read.qxmd.com/read/33737455/breathing-training-improves-exercise-capacity-in-patients-with-tetralogy-of-fallot-a-randomised-trial
#20
Julia Hock, Julia Remmele, Renate Oberhoffer, Peter Ewert, Alfred Hager
OBJECTIVE: Patients with tetralogy of Fallot (ToF) have limited pulmonary blood flow before corrective surgery and ongoing dysfunction of the pulmonary valve and right ventricle throughout life leading to lower exercise capacity and lung volumes in many patients. Inhalation training can increase lung volumes, improve pulmonary blood flow and consequently exercise capacity. This study tests whether home-based daily breathing training improves exercise capacity and lung volumes. METHODS: From February 2017 to November 2018, 60 patients (14...
March 18, 2021: Heart
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