Yongjie Xie, Tianxing Zhou, Xueyang Li, Kaili Zhao, Weiwei Bai, Xupeng Hou, Ziyun Liu, Bo Ni, Zhaoyu Zhang, Jingrui Yan, Yifei Wang, Wenna Jiang, Hongwei Wang, Antao Chang, Song Gao, Tiansuo Zhao, Shengyu Yang, Chongbiao Huang, Jing Liu, Jihui Hao
BACKGROUND & AIMS: Since pancreatic cancer responds poorly to chemotherapy and immunotherapy, it is necessary to identify novel targets and compounds to overcome resistance to treatment. METHODS: This study analyzed genomic SNP sequencing, single-cell RNA sequencing, and spatial transcriptomics. Ehf-knockout mice, KPC (LSL-KrasG12D/+ , LSL-Trp53R172H/+ and Pdx1-Cre) mice, CD45.1+BALB/C nude mice, and CD34+humanized mice were also used as subjects. Multiplexed immunohistochemistry and flow cytometry were performed to investigate the proportion of tumor-infiltrated CXCR2+neutrophils...
March 14, 2024: Gastroenterology