journal
https://read.qxmd.com/read/34314683/unlocking-the-mind-might-be-critical-in-management-of-eosinophilic-esophagitis-expanding-beyond-drugs-dilation-and-diet
#1
EDITORIAL
Rishi D Naik, Dhyanesh A Patel
No abstract text is available yet for this article.
July 24, 2021: Gastroenterology
https://read.qxmd.com/read/34303660/pathophysiology-and-biomarker-potential-of-fatty-acid-ethyl-ester-elevation-during-alcoholic-pancreatitis
#2
Stacie Vela, Andre Guerra, Gail Farrell, Shubham Trivedi, Hally Chaffin, Christopher Rood, Ravinder Singh, Sergiy Kostenko, Yu-Hui Chang, Christine Snozek, Krutika Patel, Biswajit Khatua, Vijay P Singh
BACKGROUND: The role of fatty acid ethyl esters (FAEEs) during human alcoholic pancreatitis is unknown. We compared FAEE levels to their non-esterified fatty acids (NEFA) precursors during alcohol intoxication and clinical alcoholic pancreatitis. The pathophysiology underlying FAEE increase and their role as diagnostic biomarkers for alcoholic pancreatitis was investigated METHODS: A prospective blinded study compared FAEE, NEFA and ethanol blood levels on hospitalization for alcoholic pancreatitis (n=31), alcohol intoxication (n=25) and in normal controls (n=43)...
July 22, 2021: Gastroenterology
https://read.qxmd.com/read/34303659/a-novel-role-of-circular-rna-in-intestinal-epithelial-repair
#3
EDITORIAL
Devesha H Kulkarni, Rodney D Newberry
No abstract text is available yet for this article.
July 22, 2021: Gastroenterology
https://read.qxmd.com/read/34303658/agr2-dependent-nuclear-import-of-rna-polymerase-ii-constitutes-a-specific-target-of-pancreatic-ductal-adenocarcinoma-in-the-context-of-wild-type-p53
#4
Zhiheng Zhang, Hongzhen Li, Yibin Deng, Kathleen Schuck, Susanne Raulefs, Nadja Maeritz, Yuanyuan Yu, Torsten Hechler, Andreas Pahl, Vanesa Fernández-Sáiz, Yuan Wan, Guosheng Wang, Thomas Engleitner, Rupert Öllinger, Roland Rad, Maximilian Reichert, Kalliope N Diakopoulos, Verena Weber, Jingjing Li, Shanshan Shen, Xiaoping Zou, Jörg Kleeff, Andre Mihaljevic, Christoph W Michalski, Hana Algül, Helmut Friess, Bo Kong
BACKGROUND AND AIM: Promoted by pancreatitis, oncogenic KrasG12D triggers acinar cells' neoplastic transformation through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN). Agr2 (anterior gradient 2), a known inhibitor of p53, is detected at early stage of pancreatic ductal adenocarcinoma (PDAC) development. RNA polymerase II (RNAPII) is a key nuclear enzyme; regulation of its nuclear localization in mammalian cells represents a potential therapeutic target...
July 22, 2021: Gastroenterology
https://read.qxmd.com/read/34302840/a-most-unusual-polyposis
#5
Mahmoud Aryan, Haider Mejbel, Frederick Weber
No abstract text is available yet for this article.
July 21, 2021: Gastroenterology
https://read.qxmd.com/read/34302839/liver-resident-bystander-cd8-t-cells-contribute-to-liver-disease-pathogenesis-in-chronic-hepatitis-d-virus-infection
#6
Helenie Kefalakes, Xylia J Horgan, Min Kyung Jung, Georgios Amanakis, Devika Kapuria, Fabian J Bolte, David E Kleiner, Christopher Koh, Theo Heller, Barbara Rehermann
BACKGROUND & AIMS: The hepatitis D virus (HDV) causes the most severe form of chronic hepatitis, often progressing to cirrhosis within 5-10 years. There is no curative treatment and the mechanisms underlying the accelerated liver disease progression are unknown. METHODS: Innate and adaptive immune responses were studied in blood and liver of 24 HDV-infected patients and 30 uninfected controls by multiparameter flow cytometry in correlation with disease severity and stage...
July 21, 2021: Gastroenterology
https://read.qxmd.com/read/34310978/tvb-2640-fasn-inhibitor-for-the-treatment-of-nonalcoholic-steatohepatitis-fascinate-1-a-randomized-placebo-controlled-ph2a-trial
#7
Rohit Loomba, Rizwana Mohseni, K Jean Lucas, Julio A Gutierrez, Robert G Perry, James F Trotter, Robert S Rahimi, Stephen A Harrison, Veeral Ajmera, Jeffrey D Wayne, Marie O'Farrell, William McCulloch, Katharine Grimmer, Mary Rinella, Vincent Wai-Sun Wong, Vlad Ratziu, Gregory J Gores, Brent A Neuschwander-Tetri, George Kemble
BACKGROUND AND AIMS: Increased de novo lipogenesis creates excess intrahepatic fat and lipotoxins, propagating liver damage in nonalcoholic steatohepatitis (NASH). TVB-2640, a fatty acid synthase (FASN) inhibitor, was designed to reduce excess liver fat and directly inhibit inflammatory and fibrogenic pathways. We assessed the safety and efficacy of TVB-2640 in NASH patients in the United States. METHODS: 3V2640-CLIN-005 (FASCINATE-1) was a randomized, placebo-controlled, single-blind study at 10 US sites...
July 20, 2021: Gastroenterology
https://read.qxmd.com/read/34298022/systemic-inflammation-in-pre-clinical-ulcerative-colitis
#8
Daniel Bergemalm, Erik Andersson, Johan Hultdin, Carl Eriksson, Stephen T Rush, Rahul Kalla, Alex T Adams, Åsa V Keita, Mauro D'Amato, Fernando Gomollon, Jorgen Jahnsen, Petr Ricanek, Jack Satsangi, Dirk Repsilber, Pontus Karling, Jonas Halfvarson
BACKGROUND AND AIM: Pre-clinical ulcerative colitis is poorly defined. We aimed to characterize the pre-clinical systemic inflammation in ulcerative colitis, using a comprehensive set of proteins. METHODS: We obtained plasma samples, biobanked from individuals who later in life developed ulcerative colitis (n=72), and matched healthy controls (n=140), within a population-based screening cohort. We measured 92 proteins related to inflammation using a proximity extension assay...
July 20, 2021: Gastroenterology
https://read.qxmd.com/read/34293300/an-unusual-and-unexpected-post-esophagectomy-complication
#9
Philip Asamoah, Samuel Chang
No abstract text is available yet for this article.
July 19, 2021: Gastroenterology
https://read.qxmd.com/read/34293299/anti-microbial-antibody-response-is-associated-with-future-onset-of-crohn-s-disease-independent-of-biomarkers-of-altered-gut-barrier-function-subclinical-inflammation-and-genetic-risk
#10
Sun-Ho Lee, Williams Turpin, Osvaldo Espin-Garcia, Juan Antonio Raygoza Garay, Michelle I Smith, Haim Leibovitzh, Ashleigh Goethel, Dan Turner, David Mack, Colette Deslandres, Maria Cino, Guy Aumais, Remo Panaccione, Kevan Jacobson, Alain Bitton, A Hillary Steinhart, Hien Q Huynh, Fred Princen, Paul Moayyedi, Anne M Griffiths, Mark S Silverberg, Andrew D Paterson, Wei Xu, Kenneth Croitoru
BACKGROUND: /Aim: Altered host immune reactivity to microbial antigens is hypothesized to trigger the onset of Crohn's disease (CD). We aimed to assess whether increased serum anti-microbial antibody response in asymptomatic first-degree relatives (FDR) of CD patients is an independent risk factor for future CD development. METHODS: We measured host serum antibody response to six microbial antigens at enrollment (Prometheus ELISA test: ASCA IgA/IgG, anti-OmpC, anti-A4-Fla2, anti-FlaX, anti-CBir1) and derived the sum of positive antibodies (AS)...
July 19, 2021: Gastroenterology
https://read.qxmd.com/read/34293298/comparison-of-culture-with-antibiogram-to-ngs-using-bacterial-isolates-and-formalin-fixed-paraffin-embedded-gastric-biopsies
#11
Kristina G Hulten, Robert M Genta, Ira N Kalfus, Yi Zhou, Hongjun Zhang, David Y Graham
INTRODUCTION: The decline in Helicobacter pylori cure rates emphasizes the need for readily available methods to determine antimicrobial susceptibility. AIM: To compare targeted next generation sequencing (NGS) and culture-based H. pylori susceptibility testing using clinical isolates and paired formalin-fixed paraffin embedded gastric biopsies (FFPE). METHODS: H. pylori isolates and FFPE tissues were tested for susceptibility to amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline and rifabutin using agar dilution and NGS targeted to 23S rRNA, gyrA, 16S rRNA, pbp1, rpoB and rdxA...
July 19, 2021: Gastroenterology
https://read.qxmd.com/read/34284037/outcomes-of-sars-cov-2-infection-in-patients-with-chronic-liver-disease-and-cirrhosis-a-n3c-study
#12
Jin Ge, Mark J Pletcher, Jennifer C Lai
BACKGROUND AND AIMS: In chronic liver disease (CLD) patients with or without cirrhosis, existing studies on the outcomes with SARS-CoV-2 infection have limited generalizability. We used the National COVID Cohort Collaborative (N3C), a harmonized electronic health record (EHR) dataset of 6.4 million, to describe SARS-CoV-2 outcomes in patients with CLD and cirrhosis. METHODS: We identified all CLD patients with or without cirrhosis who had SARS-CoV-2 testing in the N3C Data Enclave as of 7/1/2021...
July 17, 2021: Gastroenterology
https://read.qxmd.com/read/34284036/serial-ctdna-detection-using-a-personalized-tumor-informed-assay-in-esophageal-adenocarcinoma-patients-following-resection
#13
Emma Ococks, Shruti Sharma, Alvin Wei Tian Ng, Alexey Aleshin, Rebecca C Fitzgerald, Elizabeth Smyth, Rebecca C Fitzgerald, Paul A W Edwards, Nicola Grehan, Barbara Nutzinger, Elwira Fidziukiewicz, Aisling M Redmond, Alex Northrop, Sujath Abbas, Elizabeth C Smyth, Maria O'Donovan, Ahmad Miremadi, Shalini Malhotra, Monika Tripathi, Amber Grantham, Calvin Cheah, Hannah Coles, Connor Flint, Matthew Eldridge, Maria Secrier, Ginny Devonshire, Sriganesh Jammula, Jim Davies, Charles Crichton, Nick Carroll, Richard H Hardwick, Peter Safranek, Andrew Hindmarsh, Vijayendran Sujendran, Stephen J Hayes, Yeng Ang, Andrew Sharrocks, Shaun R Preston, Izhar Bagwan, Vicki Save, Richard J E Skipworth, Ted R Hupp, J Robert O'Neill, Olga Tucker, Andrew Beggs, Philippe Taniere, Sonia Puig, Gianmarco Contino, Timothy J Underwood, Robert C Walker, Ben L Grace, Jesper Lagergren, James Gossage, Andrew Davies, Fuju Chang, Ula Mahadeva, Vicky Goh, Francesca D Ciccarelli, Grant Sanders, Richard Berrisford, David Chan, Ed Cheong, Bhaskar Kumar, L Sreedharan, Simon L Parsons, Irshad Soomro, Philip Kaye, John Saunders, Laurence Lovat, Rehan Haidry, Michael Scott, Sharmila Sothi, Suzy Lishman, George B Hanna, Christopher J Peters, Krishna Moorthy, Anna Grabowska, Richard Turkington, Damian McManus, Helen Coleman, Russell D Petty
No abstract text is available yet for this article.
July 17, 2021: Gastroenterology
https://read.qxmd.com/read/34280390/sirt5-s-got1-up-on-pdac
#14
EDITORIAL
Surinder Kumar, David B Lombard
No abstract text is available yet for this article.
July 16, 2021: Gastroenterology
https://read.qxmd.com/read/34280389/acute-colitis-heralding-pulmonary-hemorrhage
#15
Martin Windpessl, Andrea Malzner, Eva M Seiringer
No abstract text is available yet for this article.
July 16, 2021: Gastroenterology
https://read.qxmd.com/read/34280388/an-unusual-case-of-symptomatic-portal-hypertension
#16
Peng Ye, Hongfei Miao, Yong Chen
No abstract text is available yet for this article.
July 16, 2021: Gastroenterology
https://read.qxmd.com/read/34280387/measuring-droplets-expelled-during-endoscopy-to-investigate-covid-19-transmission-risk
#17
Mark F Coughlan, Mandeep S Sawhney, Douglas K Pleskow, Conor J Sheil, Le Qiu, Lev T Perelman, Umar Khan, Mohammad Bilal, Joseph D Feuerstein, Xuejun Zhang, Maria Glyavina, Yuri N Zakharov, Tyler M Berzin, Lei Zhang, Irving Itzkan
No abstract text is available yet for this article.
July 16, 2021: Gastroenterology
https://read.qxmd.com/read/34280386/an-unusual-cause-of-erythema-on-both-lower-legs-in-a-patient-with-crohn%C3%A2-s-disease
#18
Ingmar Mederacke, Miriam Wiestler, Heiner Wedemeyer
No abstract text is available yet for this article.
July 16, 2021: Gastroenterology
https://read.qxmd.com/read/34280385/a-rare-case-of-ileocecal-intussusception-in-an-adult
#19
Uichiro Fuchizaki, Takuya Seike
No abstract text is available yet for this article.
July 16, 2021: Gastroenterology
https://read.qxmd.com/read/34280384/endoscopic-submucosal-dissection-in-the-west-making-progress-toward-a-promising-future
#20
EDITORIAL
Yutaka Tomizawa, Joo Ha Hwang
No abstract text is available yet for this article.
July 16, 2021: Gastroenterology
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