journal
https://read.qxmd.com/read/36436593/pten-deficiency-facilitates-exosome-secretion-and-metastasis-in-cholangiocarcinoma-by-impairing-tfeb-mediated-lysosome-biogenesis
#1
JOURNAL ARTICLE
Tian-Yi Jiang, Yuan-Yuan Shi, Xiao-Wen Cui, Yu-Fei Pan, Yun-Kai Lin, Xiao-Fan Feng, Zhi-Wen Ding, Chun Yang, Ye-Xiong Tan, Li-Wei Dong, Hong-Yang Wang
BACKGROUND & AIMS: In eukaryotes, the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP) are essential for maintaining cellular proteostasis and associated with cancer progression. Our previous studies have demonstrated that phosphatase and tensin homolog (PTEN), one of the most frequently mutated genes in human cancers, limits proteasome abundance and determines chemosensitivity to proteasome inhibitors in cholangiocarcinoma (CCA). However, whether PTEN regulates the lysosome pathway remains unclear...
November 24, 2022: Gastroenterology
https://read.qxmd.com/read/36427544/a-new-evaluation-method-for-remission-of-ulcerative-colitis
#2
LETTER
Yanan Li, Shizhang Pengbo, Yifei Feng
No abstract text is available yet for this article.
November 22, 2022: Gastroenterology
https://read.qxmd.com/read/36423691/letter-to-editor-regarding-final-analysis-of-diagnostic-endoscopic-resection-followed-by-selective-chemoradiotherapy-for-stage-i-esophageal-cancer-jcog0508-by-keiji-nihei-et-al
#3
LETTER
https://read.qxmd.com/read/36410444/shining-a-light-on-barrier-function
#4
EDITORIAL
Matthias Friedrich, Simon Travis
No abstract text is available yet for this article.
November 18, 2022: Gastroenterology
https://read.qxmd.com/read/36410443/promote-or-prevent-gut-microbial-function-and-immune-status-may-determine-the-effect-of-fiber-in-ibd
#5
EDITORIAL
Andrea Shin, Purna C Kashyap
No abstract text is available yet for this article.
November 18, 2022: Gastroenterology
https://read.qxmd.com/read/36402193/the-case-for-flip-panometry-in-clinical-practice
#6
LETTER
Dustin A Carlson, Peter J Kahrilas
No abstract text is available yet for this article.
November 16, 2022: Gastroenterology
https://read.qxmd.com/read/36402192/loss-of-suv420h2-dependent-chromatin-compaction-drives-right-sided-colon-cancer-progression
#7
JOURNAL ARTICLE
Verawan Boonsanay, Mohammed H Mosa, Mario Looso, Dieter Weichenhan, Fatih Ceteci, Lorenz Pudelko, Andre Lechel, Christian S Michel, Carsten Künne, Henner F Farin, Christoph Plass, Florian R Greten
BACKGROUND & AIMS: Epigenetic processes regulating gene expression contribute markedly to epithelial cell plasticity in colorectal carcinogenesis. The lysine methyltransferase SUV420H2 comprises an important regulator of epithelial plasticity and is primarily responsible for trimethylation of H4K20 (H4K20me3). Loss of H4K20me3 has been suggested as a hallmark of human cancer due to its interaction with DNMT1. However, the role of Suv4-20h2 in colorectal cancer is unknown. METHODS: We examined the alterations in histone modifications in patient-derived colorectal cancer organoids...
November 16, 2022: Gastroenterology
https://read.qxmd.com/read/36402191/hepatocyte-kctd17-inhibition-ameliorates-glucose-intolerance-and-hepatic-steatosis-caused-by-obesity-induced-chrebp-stabilization
#8
JOURNAL ARTICLE
Ah-Reum Oh, Yelin Jeong, Junjie Yu, Dao Thi Minh Tam, Jin Ku Kang, Young Hoon Jung, Seung-Soon Im, Sang Bae Lee, Dongryeol Ryu, Utpal B Pajvani, KyeongJin Kim
BACKGROUND AND AIMS: Obesity predisposes to type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), but underlying mechanisms are incompletely understood. Potassium channel tetramerization domain-containing protein 17 (Kctd17) levels are increased in livers from obese mice and humans. In this study, we investigated mechanism of increased Kctd17 and whether it is causal to obesity-induced metabolic complications. METHODS: We transduced Rosa26-LSL-Cas9 knock-in mice with AAV8-TBG-Cre (Control), AAV8-U6-Kctd17 sgRNA-TBG-Cre (L-Kctd17), AAV8-U6-Oga sgRNA-TBG-Cre (L-Oga), or AAV8-U6-Kctd17/Oga sgRNA-TBG-Cre (DKO)...
November 16, 2022: Gastroenterology
https://read.qxmd.com/read/36402190/n-glycosylation-regulates-intrinsic-ifn-%C3%AE-resistance-in-colorectal-cancer-implications-for-immunotherapy
#9
JOURNAL ARTICLE
Julia Krug, Gabriele Rodrian, Katja Petter, Hai Yang, Svetlana Khoziainova, Wei Guo, Alan Bénard, Susanne Merkel, Susan Gellert, Simone Maschauer, Monika Spermann, Maximilian Waldner, Peter Bailey, Christian Pilarsky, Andrea Liebl, Philipp Tripal, Jan Christoph, Elisabeth Naschberger, Roland Croner, Vera S Schellerer, Christoph Becker, Arndt Hartmann, Thomas Tüting, Olaf Prante, Robert Grützmann, Sergei I Grivennikov, Michael Stürzl, Nathalie Britzen-Laurent
BACKGROUND: Advanced colorectal carcinoma (CRC) is characterized by a high frequency of primary immune evasion and refractoriness to immunotherapy. Given the importance of IFN-γ in CRC immunosurveillance, we investigated whether and how acquired IFN-γ resistance in tumor cells would promote tumor growth, and whether IFN-γ sensitivity could be restored. METHODS: Spontaneous and colitis-associated CRC development was induced in mice with a specific IFN-γ pathway inhibition in intestinal epithelial cells...
November 16, 2022: Gastroenterology
https://read.qxmd.com/read/36410445/dysregulated-amino-acid-sensing-drives-colorectal-cancer-growth-and-metabolic-reprogramming-leading-to-chemoresistance
#10
JOURNAL ARTICLE
Sumeet Solanki, Katherine Sanchez, Varun Ponnusamy, Vasudha Kota, Hannah N Bell, Chun-Seok Cho, Allison H Kowalsky, Michael Green, Jun Hee Lee, Yatrik M Shah
BACKGROUND AND AIMS: CRC is a devastating disease highly modulated by dietary nutrients. mTORC1 contributes to tumor growth and limits therapy responses. Growth factor signaling is a major mechanism of mTORC1 activation. However, compensatory pathways exist to sustain mTORC1 activity following therapies that target oncogenic growth factor signaling. Amino acids potently activate mTORC1 via amino acid sensing GTPase activity towards Rags complexes (GATOR). The role of amino acid sensing pathways in CRC is unclear...
November 15, 2022: Gastroenterology
https://read.qxmd.com/read/36400180/organex-a-promising-solution-for-rescuing-organs-following-prolonged-ischemia
#11
JOURNAL ARTICLE
Anh Thu Nguyen-Lefebvre, Mamatha Bhat
No abstract text is available yet for this article.
November 15, 2022: Gastroenterology
https://read.qxmd.com/read/36396516/new-sections-in-gastroenterology-gastro-curbside-consult-and-gastro-grand-rounds
#12
JOURNAL ARTICLE
Gottumukkala Subba Raju, Peush Sahni, Sachin Wani
No abstract text is available yet for this article.
November 14, 2022: Gastroenterology
https://read.qxmd.com/read/36395873/guardian-intermediary-or-perpetrator-new-insights-into-environmental-exposure-the-gut-microbiome-and-nafld
#13
JOURNAL ARTICLE
Jiameng Sun, Brian DeBosch
No abstract text is available yet for this article.
November 14, 2022: Gastroenterology
https://read.qxmd.com/read/36395872/comments-on-diversity-equity-and-inclusion-in-gastroenterology-and-hepatology-a-survey-of-where-we-stand
#14
LETTER
Han Zhang, Yan Peng, Xiaowei Tang
No abstract text is available yet for this article.
November 14, 2022: Gastroenterology
https://read.qxmd.com/read/36395871/diarrhea-colonic-stenoses-and-a-kinase-inhibitor
#15
JOURNAL ARTICLE
Ferga C Gleeson, Thomas C Smyrk, Stephanie L Hansel
No abstract text is available yet for this article.
November 14, 2022: Gastroenterology
https://read.qxmd.com/read/36395870/moderate-fluid-resuscitation-is-preferable-in-acute-pancreatitis
#16
JOURNAL ARTICLE
Ville Sallinen
No abstract text is available yet for this article.
November 14, 2022: Gastroenterology
https://read.qxmd.com/read/36379248/selective-use-of-esd-appropriate-for-large-non-pedunculated-colorectal-neoplasms
#17
LETTER
Douglas K Rex, Heiko Pohl
No abstract text is available yet for this article.
November 12, 2022: Gastroenterology
https://read.qxmd.com/read/36379247/reply-the-definition-of-lean-is-not-so-benign
#18
LETTER
Michelle T Long, Mazen Noureddin, Joseph K Lim
No abstract text is available yet for this article.
November 12, 2022: Gastroenterology
https://read.qxmd.com/read/36379246/-am-i-going-to-die-delivering-serious-news-to-patients-with-liver-disease
#19
JOURNAL ARTICLE
Arpan A Patel, Robert M Arnold, Tamar Taddei, Christopher D Woodrell
No abstract text is available yet for this article.
November 12, 2022: Gastroenterology
https://read.qxmd.com/read/36379245/response-to-the-letter-to-the-editor
#20
LETTER
Williams Turpin, Sun-Ho Lee, Croitoru Kenneth
No abstract text is available yet for this article.
November 12, 2022: Gastroenterology
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