journal
https://read.qxmd.com/read/38494037/comments-on-global-prevalence-of-helicobacter-pylori-infection-and-incidence-of-gastric-cancer-between-1980-and-2022
#1
LETTER
Jia Xu, Mingming Deng, Xiaowei Tang
No abstract text is available yet for this article.
March 15, 2024: Gastroenterology
https://read.qxmd.com/read/38494036/disparities-in-gastric-cancer-screening-a-comparative-analysis-of-japan-and-south-korea
#2
LETTER
Yasutoshi Shiratori, Naoki Ishii, Anthony Kalloo
No abstract text is available yet for this article.
March 15, 2024: Gastroenterology
https://read.qxmd.com/read/38494035/three-dimensional-imaging-of-the-enteric-nervous-system-in-human-pediatric-colon-reveals-new-features-of-hirschsprung-disease
#3
JOURNAL ARTICLE
Joshua D Eisenberg, Rebecca P Bradley, Kahleb D Graham, Rachel H Ceron, Amanda M Lemke, Benjamin J Wilkins, Ali Naji, Robert O Heuckeroth
BACKGROUND AND AIMS: Hirschsprung disease is defined by the absence of enteric nervous system (ENS) from distal bowel. Primary treatment is "pull-through" surgery to remove bowel that lacks ENS with re-anastomosis of "normal" bowel near the anal verge. Problems after pull-through are common and some may be due to retained hypoganglionic bowel (i.e., low ENS density). Testing this hypothesis has been difficult because counting enteric neurons in tissue sections is unreliable even for experts...
March 15, 2024: Gastroenterology
https://read.qxmd.com/read/38493380/correction
#4
(no author information available yet)
No abstract text is available yet for this article.
March 15, 2024: Gastroenterology
https://read.qxmd.com/read/38493379/correction
#5
(no author information available yet)
No abstract text is available yet for this article.
March 15, 2024: Gastroenterology
https://read.qxmd.com/read/38492894/targeting-ese3-ehf-with-nifurtimox-inhibits-cxcr2-neutrophil-infiltration-and-overcomes-pancreatic-cancer-resistance-to-chemotherapy-and-immunotherapy
#6
JOURNAL ARTICLE
Yongjie Xie, Tianxing Zhou, Xueyang Li, Kaili Zhao, Weiwei Bai, Xupeng Hou, Ziyun Liu, Bo Ni, Zhaoyu Zhang, Jingrui Yan, Yifei Wang, Wenna Jiang, Hongwei Wang, Antao Chang, Song Gao, Tiansuo Zhao, Shengyu Yang, Chongbiao Huang, Jing Liu, Jihui Hao
BACKGROUND & AIMS: Since pancreatic cancer responds poorly to chemotherapy and immunotherapy, it is necessary to identify novel targets and compounds to overcome resistance to treatment. METHODS: This study analyzed genomic SNP sequencing, single-cell RNA sequencing, and spatial transcriptomics. Ehf-knockout mice, KPC (LSL-KrasG12D/+ , LSL-Trp53R172H/+ and Pdx1-Cre) mice, CD45.1+BALB/C nude mice, and CD34+humanized mice were also used as subjects. Multiplexed immunohistochemistry and flow cytometry were performed to investigate the proportion of tumor-infiltrated CXCR2+neutrophils...
March 14, 2024: Gastroenterology
https://read.qxmd.com/read/38492893/helicobacter-pylori-therapy-and-risk-of-gastric-cancer-after-endoscopic-resection-of-dysplasia-a-sensitivity-analysis-assessing-impact-of-unmeasured-confounding
#7
LETTER
Guo-Fu Li, Yu-Wei Qiao, Guo Yu
No abstract text is available yet for this article.
March 14, 2024: Gastroenterology
https://read.qxmd.com/read/38492892/amphiregulin-switches-progenitor-cell-fate-for-lineage-commitment-during-gastric-mucosal-regeneration
#8
JOURNAL ARTICLE
Su-Hyung Lee, Yoonkyung Won, David Gibbs, Brianna Caldwell, Anna Goldstein, Eunyoung Choi, James R Goldenring
BACKGROUND & AIMS: Isthmic progenitors, tissue-specific stem cells in the stomach corpus, maintain mucosal homeostasis by balancing between proliferation and differentiation to gastric epithelial lineages. The progenitor cells rapidly adopt an active state in response to mucosal injury. However, it remains unclear how the isthmic progenitor cell niche is controlled during the regeneration of damaged epithelium. METHODS: We recapitulated tissue recovery process after acute mucosal injury in the mouse stomach...
March 14, 2024: Gastroenterology
https://read.qxmd.com/read/38485096/novel-multimodal-database-for-metabolic-dysfunction-associated-steatotic-liver-disease-linking-genes-to-outcomes
#9
JOURNAL ARTICLE
Sara Naimimohasses, Mamatha Bhat
No abstract text is available yet for this article.
March 12, 2024: Gastroenterology
https://read.qxmd.com/read/38467384/biopsy-proteome-scoring-to-determine-mucosal-remodeling-in-celiac-disease
#10
JOURNAL ARTICLE
Anette Johansen, Geir Kjetil F Sandve, Jostein Holen Ibsen, Knut E A Lundin, Ludvig M Sollid, Jorunn Stamnaes
BACKGROUND & AIMS: Histological evaluation of gut biopsies is a cornerstone for diagnosis and management of celiac disease (CeD). Despite its wide use, the method depends on proper biopsy orientation, and it suffers from inter-observer variability. Biopsy proteome measurement reporting on tissue state can be obtained by mass spectrometry (MS) analysis of formalin-fixed paraffin embedded (FFPE) tissue. Here we aimed to transform biopsy proteome data into numerical scores that give observer-independent measures of mucosal remodeling in CeD...
March 9, 2024: Gastroenterology
https://read.qxmd.com/read/38467383/thoracoabdominal-wall-motion-guided-biofeedback-treatment-of-abdominal-distension-a-randomized-placebo-controlled-trial
#11
JOURNAL ARTICLE
Elizabeth Barba, Dan M Livovsky, Anna Accarino, Fernando Azpiroz
BACKGROUND AND AIMS: Abdominal distention results from abdominophrenic dyssynergia (diaphragmatic contraction and abdominal wall relaxation) in patients with disorders of the gut-brain interaction. This study aimed to validate a simple biofeedback procedure, guided by abdominothoracic wall motion, for treating abdominal distension. METHODS: In this randomized, parallel, placebo-controlled trial, 42 consecutive patients (36 women and 6 men; age, 17-64 years) with meal-triggered visible abdominal distension were recruited...
March 9, 2024: Gastroenterology
https://read.qxmd.com/read/38467382/genetic-deletion-of-galectin-3-inhibits-pancreatic-cancer-progression-and-enhances-the-efficacy-of-immunotherapy
#12
JOURNAL ARTICLE
Daowei Yang, Xinlei Sun, Rohan Moniruzzaman, Hua Wang, Citu Citu, Zhongming Zhao, Ignacio I Wistuba, Huamin Wang, Anirban Maitra, Yang Chen
BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) has a desmoplastic tumor stroma and immunosuppressive microenvironment. Galectin-3 (GAL3) is enriched in PDAC, highly expressed by cancer cells and myeloid cells. However, the functional roles of GAL3 in the PDAC microenvironment remain elusive. METHODS: We generated a novel transgenic mouse model (KPPC;Lgals3-/- ) that allows the genetic depletion of GAL3 from both cancer cells and myeloid cells in spontaneous PDAC formation...
March 9, 2024: Gastroenterology
https://read.qxmd.com/read/38460608/a-baby-step-or-a-real-giant-stride-histomic-enabled-by-artificial-intelligence-to-predict-treatment-response-in-pediatric-patients-with-ulcerative-colitis
#13
EDITORIAL
Marietta Iacucci, Yasuharu Maeda, Subrata Ghosh
No abstract text is available yet for this article.
March 7, 2024: Gastroenterology
https://read.qxmd.com/read/38460607/how-close-is-close-enough-improving-observational-study-design-to-compare-the-effectiveness-of-health-interventions
#14
EDITORIAL
Sanjay K Murthy
No abstract text is available yet for this article.
March 7, 2024: Gastroenterology
https://read.qxmd.com/read/38460606/celiac-disease-related-conditions-who-to-test
#15
JOURNAL ARTICLE
Fabiana Zingone, Julio C Bai, Christophe Cellier, Jonas F Ludvigsson
Celiac disease (CeD) is a chronic immune-mediated condition triggered by gluten consumption in genetically predisposed individuals. Approximately 1% of the general population is affected by the disorder. Disease presentation is heterogeneous, and despite growing awareness among physicians and the public, it continues to be underestimated. The most effective strategy for identifying undiagnosed CeD is proactive case-finding through serologic testing in high-risk groups. We reviewed the most recent evidence on the association between CeD and over 20 conditions...
March 7, 2024: Gastroenterology
https://read.qxmd.com/read/38458541/colorectal-tumor-recurrence-on-a-mysterious-spot
#16
JOURNAL ARTICLE
D A Verhoeven, A S L P Crobach, J J Boonstra
No abstract text is available yet for this article.
March 6, 2024: Gastroenterology
https://read.qxmd.com/read/38456870/our-new-president-maria-t-abreu-md-agaf
#17
EDITORIAL
Uma Mahadevan, Marla Dubinsky, Iris Dotan
No abstract text is available yet for this article.
March 6, 2024: Gastroenterology
https://read.qxmd.com/read/38456869/aga-clinical-practice-update-on-diagnosis-and-management-of-cannabinoid-hyperemesis-syndrome-commentary
#18
Alberto Rubio-Tapia, Richard McCallum, Michael Camilleri
DESCRIPTION: The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update (CPU) is to review the available evidence and provide expert advice regarding diagnosis and management of cannabinoid hyperemesis syndrome. METHODS: This CPU was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership and underwent internal peer review by the CPUC and external peer review through standard procedures of Gastroenterology...
March 5, 2024: Gastroenterology
https://read.qxmd.com/read/38452825/a-colorful-conundrum-dark-urine-in-a-patient-with-inflammatory-bowel-disease
#19
JOURNAL ARTICLE
Stefan Mitev, Cvetelina Marinova, Zoya Spassova
No abstract text is available yet for this article.
March 5, 2024: Gastroenterology
https://read.qxmd.com/read/38452824/sacral-neural-crest-independent-origin-of-the-enteric-nervous-system-in-mouse
#20
JOURNAL ARTICLE
Qi Yu, Li Liu, Mengjie Du, Daniel Müller, Yan Gu, Zhigang Gao, Xiaolong Xin, Yanlan Gu, Miao He, Till Marquardt, Liang Wang
BACKGROUND & AIMS: The enteric nervous system (ENS), the gut's intrinsic nervous system critical for gastrointestinal function and gut-brain communication, is believed to mainly originate from vagal neural crest cells (vNCCs) and partially from sacral NCCs (sNCCs). Resolving the exact origins of the ENS is critical for understanding congenital ENS diseases but has been confounded by the inability to distinguish between both NCC populations in situ. Here, we aimed to resolve the exact origins of the mammalian ENS...
March 5, 2024: Gastroenterology
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