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Gastroenterology

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https://read.qxmd.com/read/31102662/eus-guided-drainage-for-infected-necrotizing-pancreatitis-better-than-surgery-but-still-lacking-treatment-protocol-standardization
#1
LETTER
Gianenrico Rizzatti, Mihai Rimbaș, Alberto Larghi
No abstract text is available yet for this article.
May 15, 2019: Gastroenterology
https://read.qxmd.com/read/31102661/re-risk-of-post-polypectomy-bleeding-with-uninterrupted-clopidogrel-therapy-in-an-industry-independent-double-blind-randomized-trial
#2
LETTER
Franco Radaelli, Giuseppe Mogavero, Silvia Paggi
No abstract text is available yet for this article.
May 15, 2019: Gastroenterology
https://read.qxmd.com/read/31102660/a-randomized-trial-of-interrupted-clopidogrel-in-patients-undergoing-polypectomy-more-questions-than-answers
#3
LETTER
Milan J Sonneveld, P Honkoop, P C J Ter Borg
No abstract text is available yet for this article.
May 15, 2019: Gastroenterology
https://read.qxmd.com/read/31102659/hot-polypectomy-a-cautionary-tale
#4
LETTER
Laura Lamonaca, Paul J Belletrutti, Alessandro Repici
No abstract text is available yet for this article.
May 15, 2019: Gastroenterology
https://read.qxmd.com/read/31102658/understanding-the-current-evidence-on-proton-pump-inhibitor-use-and-bone-health
#5
LETTER
Toshihiro Sugiyama
No abstract text is available yet for this article.
May 15, 2019: Gastroenterology
https://read.qxmd.com/read/31100380/many-patients-with-irritable-bowel-syndrome-have-atypical-food-allergies-not-associated-with-immunoglobulin-e
#6
Annette Fritscher-Ravens, Theresa Pflaum, Marie Mösinger, Zino Ruchai, Christoph Röcken, Peter J Milla, Melda Das, Martina Böttner, Thilo Wedel, Detlef Schuppan
BACKGROUND & AIMS: Confocal laser endomicroscopy (CLE) is a technique that permits real-time detection and quantification of changes in intestinal tissues and cells, including increases in intraepithelial lymphocytes and fluid extravasation through epithelial leaks. Using CLE analysis of patients with irritable bowel syndrome (IBS), we found that more than half have responses to specific food components. Exclusion of the defined food led to long-term symptom relief. We used results of CLE to detect reactions to food in a larger patient population, and analyzed duodenal biopsies and fluid from patients to investigate mechanisms of these reactions...
May 14, 2019: Gastroenterology
https://read.qxmd.com/read/31095950/a-summary-of-the-fight-colorectal-cancer-working-meeting-exploring-risk-factors-and-etiology-of-sporadic-early-age-onset-colorectal-cancer
#7
Andrea J Dwyer, Caitlin C Murphy, C Richard Boland, Reese Garcia, Heather Hampel, Paul Limburg, Jan Lowery, Ann G Zauber, Stephen Waring, Sharyn Worrall, Jose Perea, Rebecca Siegel, Jeffrey Lee, Christine Molmenti, Cynthia L Sears, Phillip Buckhaults, Richard Hayes, Hisham Hussan, Noel de Miranda, Claire Palles, Luis Diaz, Mingyang Song, Andrea Cercek, Christopher H Lieu, Swati G Patel, Jordan J Karlitz, Yin Cao, Josh Demb, Patrick Blatchford, Betsy Risendal, Elsa Weltzien, Anil Wali, Phil Daschner, Holli Loomans-Kropp, Flores R, Caleb L Levell, Karen Wehling, Jessica Martin, Curt Pesmen, Violet Kuchar, Ryan Soisson, Anjee Davis, Dennis Ahnen
No abstract text is available yet for this article.
May 13, 2019: Gastroenterology
https://read.qxmd.com/read/31095949/bifidobacterium-breve-bif195-protects-against-small-intestinal-damage-caused-by-acetylsalicylic-acid-in-healthy-volunteers
#8
Brynjulf Mortensen, Clodagh Murphy, John O'Grady, Mary Lucey, Gafer Elsafi, Lillian Barry, Vibeke Westphal, Anja Wellejus, Oksana Lukjancenko, Aron C Eklund, Henrik Bjørn Nielsen, Adam Baker, Anders Damholt, Johan E T van Hylckama Vlieg, Fergus Shanahan, Martin Buckley
BACKGROUND & AIMS: Enteropathy and small-intestinal ulcers are common side effects of non-steroidal anti-inflammatory drugs such as acetylsalicylic acid (ASA). Safe, cytoprotective strategies are needed to reduce this risk. Specific Bifidobacteria might have cytoprotective activities, but little is known about these effects in humans. We used serial video capsule endoscopy (VCE) to assess the efficacy of a specific Bifidobacterium strain in healthy volunteers exposed to ASA. METHODS: We performed a single-site, double-blind, parallel-group, proof of concept analysis of 75 heathy volunteers given ASA (300 mg) daily for 6 weeks, from July 31 through October 24, 2017...
May 13, 2019: Gastroenterology
https://read.qxmd.com/read/31085197/how-to-use-emotional-intelligence-as-a-career-catalyst-the-x-factor-of-success-for-trainees-and-faculty-in-gih
#9
V H Shah, P P Shah
No abstract text is available yet for this article.
May 11, 2019: Gastroenterology
https://read.qxmd.com/read/31085196/clinical-guide-and-update-on-porphyrias
#10
REVIEW
Ulrich Stölzel, Manfred O Doss, Detlef Schuppan
Physicians should be aware of porphyrias, which could be responsible for unexplained gastrointestinal, neurologic, or skin disorders. Despite their relative rarity and complexity, most porphyrias can be easily defined and diagnosed. They are caused by well-characterized enzyme defects in the complex heme biosynthetic pathway and are divided into categories of acute vs non-acute or hepatic vs erythropoietic porphyrias. Acute hepatic porphyrias (acute intermittent porphyria, variegate porphyria, hereditary coproporphyria, and aminolevulinic acid dehydratase deficient porphyria) manifest in attacks and are characterized by overproduction of porphyrin precursors, producing often serious abdominal, psychiatric, neurologic, or cardiovascular symptoms...
May 11, 2019: Gastroenterology
https://read.qxmd.com/read/31082367/pathogenesis-and-cells-of-origin-of-barrett-s-esophagus
#11
REVIEW
Jianwen Que, Katherine S Garman, Rhonda F Souza, Stuart Jon Spechler
In patients with Barrett's esophagus (BE), metaplastic columnar mucosa, containing epithelial cells with gastric and intestinal features, replaces esophageal squamous mucosa damaged by gastroesophageal reflux disease. This condition is estimated to affect 5.6% of adults in the United States, and is a major risk factor for esophageal adenocarcinoma. Despite the prevalence and importance of BE, its pathogenesis is incompletely understood and there are disagreements over the cells of origin. We review mechanisms of BE pathogenesis, including transdifferentiation and transcommitment, and discuss potential cells of origin including basal cells of the squamous epithelium, cells of esophageal submucosal glands and their ducts, cells of the proximal stomach, and specialized populations of cells at the esophago-gastric junction (residual embryonic cells and transitional basal cells)...
May 10, 2019: Gastroenterology
https://read.qxmd.com/read/31078625/endoscopic-surveillance-of-barrett-s-esophagus-using-volumetric-laser-endomicroscopy-with-artificial-intelligence-image-enhancement
#12
Arvind J Trindade, Matthew McKinley, Cathy Fan, Cadman Leggett, Allon Kahn, Douglas Pleskow
No abstract text is available yet for this article.
May 9, 2019: Gastroenterology
https://read.qxmd.com/read/31078623/a-rare-cause-of-paradoxical-nausea-and-abdominal-pain
#13
Andree H Koop, Raouf E Nakhleh, Ming-Hsi Wang
No abstract text is available yet for this article.
May 9, 2019: Gastroenterology
https://read.qxmd.com/read/31078622/amino-acid-substitutions-in-genotype-3a-hepatitis-c-virus-polymerase-protein-affect-responses-to-sofosbuvir
#14
Peter A C Wing, Meleri Jones, Michelle Cheung, Sampath DaSilva, Connor Bamford, Wing-Yiu Jason Lee, Elihu Aranday-Cortes, Ana Da Silva Filipe, John McLauchlan, David Smith, William Irving, Morven Cunningham, Azim Ansari, Eleanor Barnes, Graham R Foster
BACKGROUND & AIMS: Sofosbuvir is a frequently used pan-genotype inhibitor of hepatitis C virus (HCV) polymerase. This drug eliminates most chronic HCV infections and resistance-associated substitutions in the polymerase are rare. However, HCV genotype 3 responds slightly less well to sofosbuvir-based therapies than other genotypes. We collected data from England's National Health Service Early Access Program to search for virus factors associated with sofosbuvir treatment failure...
May 9, 2019: Gastroenterology
https://read.qxmd.com/read/31078621/regulation-of-ph-by-carbonic-anhydrase-9-mediates-survival-of-pancreatic-cancer-cells-with-activated-kras-in-response-to-hypoxia
#15
Paul C McDonald, Shawn C Chafe, Wells S Brown, Saeed Saberi, Mridula Swayampakula, Geetha Venkateswaran, Oksana Nemirovsky, Jordan A Gillespie, Joanna M Karasinska, Steven E Kalloger, Claudiu T Supuran, David F Schaeffer, Ali Bashashati, Sohrab P Shah, James T Topham, Donald T Yapp, Jinyang Li, Daniel J Renouf, Ben Z Stanger, Shoukat Dedhar
BACKGROUND & AIMS: Most pancreatic ductal adenocarcinomas (PDACs) express an activated form of KRAS, become hypoxic and dysplastic, and are refractory to chemo- and radiation-therapies. To survive in the hypoxic environment, PDAC cells upregulate enzymes and transporters involved in pH regulation, including the extracellular facing carbonic anhydrase 9 (CA9). We evaluated the effect of blocking CA9, in combination with administration of gemcitabine, in mouse models of pancreatic cancer...
May 9, 2019: Gastroenterology
https://read.qxmd.com/read/31078620/a-fist-sized-radiographic-consolidation-in-a-man-suffering-from-difficulty-swallowing
#16
Yi-Ming Chan, Wen-Hsin Huang
No abstract text is available yet for this article.
May 9, 2019: Gastroenterology
https://read.qxmd.com/read/31078624/inhibiting-interleukin-11-signaling-reduces-hepatocyte-death-and-liver-fibrosis-inflammation-and-steatosis-in-mouse-models-of-non-alcoholic-steatohepatitis
#17
Anissa A Widjaja, Brijesh K Singh, Eleonora Adami, Sivakumar Viswanathan, Jinrui Dong, Giuseppe A D'Agostino, Benjamin Ng, Wei Wen Lim, Jessie Tan, Bhairav S Paleja, Madhulika Tripathi, Sze Yun Lim, Shamini Guna Shekeran, Sonia P Chothani, Anne Rabes, Martina Sombetzki, Eveline Bruinstroop, Lio Pei Min, Rohit A Sinha, Salvatore Albani, Paul M Yen, Sebastian Schafer, Stuart A Cook
BACKGROUND & AIMS: We studied the role of interleukin 11 (IL11) signaling in the pathogenesis of nonalcoholic steatohepatitis using hepatic stellate cells (HSCs), hepatocytes, and mouse models of non-alcoholic steatohepatitis (NASH). METHODS: We stimulated mouse and human fibroblasts, HSCs, or hepatocytes with IL11 and other cytokines and analyzed them by imaging, immunoblot, and functional assays and ELISAs. Mice were given injections of IL11. Mice with disruption of the interleukin 11 receptor subunit alpha gene (Il11ra1-/- ) mice and Il11ra1+/+ mice were fed a high-fat methionine- and choline-deficient diet (HFMCD) or a Western diet with liquid fructose (WDF) to induce steatohepatitis; control mice were fed normal chow...
May 8, 2019: Gastroenterology
https://read.qxmd.com/read/31077721/perileve-an-implantable-peritoneo-vesicular-bio-powered-shunt-to-manage-patients-with-refractory-ascites
#18
Aseem Jain, Laura Scavo, Damian Cross, Matthew Petney, Caroline Garrett, Steven P Marra, Ashish Nimgaonkar
No abstract text is available yet for this article.
May 8, 2019: Gastroenterology
https://read.qxmd.com/read/31063781/gastroparesis-mimicry-thinking-beyond-the-pylorus
#19
Benjamin Nunley, Hampton Collins, Frederick Weber
No abstract text is available yet for this article.
May 4, 2019: Gastroenterology
https://read.qxmd.com/read/31063780/hemoperitoneum-from-what-where-and-why
#20
Alex Zhornitskiy, Camellia Dalai, James H Tabibian
No abstract text is available yet for this article.
May 4, 2019: Gastroenterology
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