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Gastroenterology

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https://read.qxmd.com/read/31520613/white-light-endoscopy-is-adequate-for-lynch-syndrome-surveillance-in-a-randomized-and-non-inferiority-study
#1
Liseth Rivero-Sánchez, Coral Arnau-Collell, Jesús Herrero, David Remedios, Victoria Alvarez, Eduardo Albéniz, Patricia Calvo, Jordi Gordillo, Ignasi Puig, Jorge López Vicente, Alain Huerta, María López-Cerón, Inmaculada Salces, Beatriz Peñas, Sofía Parejo, Enrique Rodriguez de Santiago, Maite Herraiz, Cristina Carretero, Antonio Z Gimeno-Garcia, Esteban Saperas, Cristina Alvarez-Urturi, Rebeca Moreira, Cristina Rodriguez de Miguel, Teresa Ocaña, Leticia Moreira, Sabela Carballal, Ariadna Sánchez, Gerhard Jung, Antoni Castells, Josep Llach, Francesc Balaguer, María Pellisé
BACKGROUND & AIMS: Dye-based pancolonic chromoendoscopy is recommended for colorectal cancer surveillance in patients with Lynch syndrome. However, there is scarce evidence to support its superiority to high-definition white-light endoscopy. We performed a prospective study assess whether in the hands of high detecting colonoscopists, high-definition, white-light endoscopy is non-inferior to pancolonic chromoendoscopy for detection of adenomas in patients with Lynch syndrome. METHODS: We conducted a parallel controlled study, from July 2016 through January 2018 at 14 centers in Spain of adults with pathogenic germline variants in mismatch repair genes (60% women; mean age, 47±14 years-old) under surveillance...
September 11, 2019: Gastroenterology
https://read.qxmd.com/read/31520612/factors-to-consider-in-development-of-drugs-for-pediatric-nonalcoholic-fatty-liver-disease
#2
EDITORIAL
Miriam B Vos, Lara Dimick-Santos, Ruby Mehta, Stephanie O Omokaro, Johannes Taminiau, Elmer Schabel, David E Kleiner, Peter Szitanyi, Piotr Socha, Jeffrey B Schwimmer, Stephanie Noviello, Debra G Silberg, Richard Torstenson, Veronica Miller, Joel E Lavine
No abstract text is available yet for this article.
September 11, 2019: Gastroenterology
https://read.qxmd.com/read/31513799/ustekinumab-and-pregnancy-continue-or-cease-before-you-conceive
#3
LETTER
Turki AlAmeel, Eman Al Sulais
No abstract text is available yet for this article.
September 9, 2019: Gastroenterology
https://read.qxmd.com/read/31513798/reply-to-letters-to-editor-re-gastro-d-19-00618-et-al
#4
LETTER
Charles N Bernstein
No abstract text is available yet for this article.
September 9, 2019: Gastroenterology
https://read.qxmd.com/read/31513797/suppressive-and-gut-reparative-functions-of-human-type-1-t-regulatory-cells
#5
Laura Cook, Martin Stahl, Xiao Han, Aisha Nazli, Katherine N MacDonald, May Q Wong, Kevin Tsai, Sara Dizzell, Kevan Jacobson, Brian Bressler, Charu Kaushic, Bruce A Vallance, Theodore S Steiner, Megan K Levings
BACKGROUND & AIMS: T-regulatory (Treg) cells suppress the immune response to maintain homeostasis. There are 2 main subsets of Treg cells: FOXP3-positive Treg cells, which do not produce high levels of effector cytokines, and type 1 Treg (Tr1) cells, which are FOXP3-negative and secrete interleukin 10 (IL10). IL10 is an anti-inflammatory cytokine, so Tr1 cells might be used in treatment of inflammatory bowel diseases. We aimed to develop methods to isolate and expand human Tr1 cells and define their functions...
September 9, 2019: Gastroenterology
https://read.qxmd.com/read/31513796/reply-to-gastro-d-19-00915
#6
LETTER
Uma Mahadevan, Susan Fisher, Laura Riley, Christina Chambers, Rajeev Jain, Christopher Robinson
No abstract text is available yet for this article.
September 9, 2019: Gastroenterology
https://read.qxmd.com/read/31513795/reply-to-gastro-d-19-00461-19-01148-and-19-00839
#7
LETTER
Tao Shen, Yimin Mao, Chengwei Chen
No abstract text is available yet for this article.
September 9, 2019: Gastroenterology
https://read.qxmd.com/read/31513794/how-to-perform-a-high-quality-peroral-endoscopic-myotomy-poem
#8
Mouen A Khashab, Amrita Sethi, Thomas Rosch, Alessandro Repici
No abstract text is available yet for this article.
September 9, 2019: Gastroenterology
https://read.qxmd.com/read/31499039/meeting-summary-2019-gut-microbiota-for-health-world-summit
#9
Gwenny M Fuhler, Gail A Hecht
No abstract text is available yet for this article.
September 6, 2019: Gastroenterology
https://read.qxmd.com/read/31499038/rates-of-elective-colectomy-for-diverticulitis-continued-to-increase-after-2006-guideline-change
#10
Paula D Strassle, Alan C Kinlaw, Nicole Chaumont, Hannah L Angle, Stephanie T Lumpkin, Mark J Koruda, Anne F Peery
No abstract text is available yet for this article.
September 6, 2019: Gastroenterology
https://read.qxmd.com/read/31493399/ca-2-influx-channel-inhibitor-saraf-protects-mice-from-acute-pancreatitis
#11
Aran Son, Malini Ahuja, Daniella M Schwartz, Arpad Varga, William Swaim, Namju Kang, Jozsef Maleth, Dong Min Shin, Shmuel Muallem
BACKGROUND & AIMS: Pancreatitis is characterized by increased influx of Ca2+ into acinar cells, by unknown mechanisms. Inhibitors of Ca2+ influx channels could be effective in treating acute pancreatitis, but these have deleterious side effects that can result in death. We investigated the expression patterns and functions of acinar cell Ca2+ channels and factors that regulate them during development of acute pancreatitis, along with changes in the channel inactivator store-operated calcium entry associated regulatory factor (SARAF)...
September 4, 2019: Gastroenterology
https://read.qxmd.com/read/31493398/prophylactic-clip-closure-clarified-the-question-is-not-whether-to-clip-but-when
#12
EDITORIAL
Douglas K Rex
No abstract text is available yet for this article.
September 4, 2019: Gastroenterology
https://read.qxmd.com/read/31493397/efficacy-and-safety-of-mirikizumab-in-a-randomized-phase-2-study-of-patients-with-ulcerative-colitis
#13
William J Sandborn, Marc Ferrante, Bal R Bhandari, Elina Berliba, Brian G Feagan, Toshifumi Hibi, Jay L Tuttle, Paul Klekotka, Stuart Friedrich, Michael Durante, MaryAnn Morgan-Cox, Janelle Laskowski, Jochen Schmitz, Geert R D'Haens
BACKGROUND & AIMS: Interleukin 23 (IL23) contributes to pathogenesis of ulcerative colitis (UC). We investigated the effects of mirikizumab, a monoclonal antibody against the p19 subunit of IL23, in a phase 2 study of patients with UC. METHODS: We performed a trial of the efficacy and safety of mirikizumab in patients with moderate to severely active UC, enrolling patients from 14 countries from January 2016 through September 2017. Patients were randomly assigned to groups given intravenous placebo (n=63), mirikizumab 50 mg (n=63) or 200 mg (n=62) with exposure-based dosing, or mirikizumab 60 mg with fixed dosing (n=61), at weeks 0, 4, and 8...
September 4, 2019: Gastroenterology
https://read.qxmd.com/read/31479658/american-gastroenterological-association-clinical-practice-update-management-of-pancreatic-necrosis
#14
REVIEW
Todd H Baron, Christopher J DiMaio, Andrew Y Wang, Katherine A Morgan
DESCRIPTION: The purpose of this AGA Institute Clinical Practice Update is to review the available evidence and expert recommendations regarding the clinical care of patients with pancreatic necrosis and to offer concise best practice advice for the optimal management of patients with this highly morbid condition. METHODS: This expert review was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the CPUC and external peer review through standard procedures of Gastroenterology...
August 31, 2019: Gastroenterology
https://read.qxmd.com/read/31479657/reply-to-gastro-d-19-01067
#15
LETTER
Kristin Ranheim Randel, Edoardo Botteri, Øyvind Holme
No abstract text is available yet for this article.
August 31, 2019: Gastroenterology
https://read.qxmd.com/read/31476300/decreased-complexity-of-serum-n-glycan-structures-associates-with-successful-fecal-microbiota-transplantation-for-recurrent-clostridioides-difficile-infection
#16
Tanya M Monaghan, Maja Pučić-Baković, Frano Vučković, Christine Lee, Dina Kao
No abstract text is available yet for this article.
August 30, 2019: Gastroenterology
https://read.qxmd.com/read/31476299/histopathology-scoring-systems-of-stenosis-associated-with-small-bowel-crohn-s-disease-a-systematic-review
#17
Ilyssa O Gordon, Dominik Bettenworth, Arne Bokemeyer, Amitabh Srivastava, Christophe Rosty, Gert E Hertogh, Marie E Robert, Mark A Valasek, Ren Mao, Satya Kurada, Noam Harpaz, Paula Borralho, Reetesh K Pai, Rish K Pai, Robert Odze, Roger Feakins, Claire E Parker, Tran Nguyen, Vipul Jairath, Mark E Baker, David H Bruining, J G Fletcher, Brian G Feagan, Florian Rieder
BACKGROUND & AIMS: Stenosis is a common complication of Crohn's disease (CD) that has no effective medical therapy. Development of anti-fibrotic agents will require testing in randomized controlled trials. Computed tomography enterography- and magnetic resonance enterography-based technologies might be used to measure outcomes in these trials. These approaches have been validated in studies of patients with symptomatic strictures who underwent imaging evaluations, followed by resection with histopathologic grading of the intestinal tissue for inflammation and/or fibrosis (the reference standard)...
August 30, 2019: Gastroenterology
https://read.qxmd.com/read/31473225/sperm-flagellar-1-binds-actin-in-intestinal-epithelial-cells-and-contributes-to-formation-of-filopodia-and-lamellipodia
#18
Rocio Tapia, Eloy A Perez-Yepez, Maximillian J Carlino, Umesh C Karandikar, Sarah E Kralicek, Mary K Estes, Gail A Hecht
BACKGROUND & AIMS: Sperm flagellar 1 (SPEF1, also called CLAMP) is a microtubule-associated protein that regulates microtubule dynamics and planar cell polarity in multi-ciliated cells. We investigated the localization and function of SPEF1, or CLAMP, in human intestinal epithelia cells (IECs). METHODS: We performed studies with SKCO-15 and human intestinal enteroids established from biopsies from different intestinal segments (duodenal, jejunum, ileal, and colon) of a single donor...
August 29, 2019: Gastroenterology
https://read.qxmd.com/read/31473224/long-term-risk-of-malignancy-in-branch-duct-intraductal-papillary-mucinous-neoplasms
#19
Hiroki Oyama, Minoru Tada, Kaoru Takagi, Keisuke Tateishi, Tsuyoshi Hamada, Yousuke Nakai, Ryunosuke Hakuta, Hideaki Ijichi, Kazunaga Ishigaki, Sachiko Kanai, Hirofumi Kogure, Suguru Mizuno, Kei Saito, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Naminatsu Takahara, Yasuyuki Morishita, Junichi Arita, Kiyoshi Hasegawa, Mariko Tanaka, Masashi Fukayama, Kazuhiko Koike
BACKGROUND & AIMS: Long-term outcomes of patients with branch-duct intraductal papillary mucinous neoplasms (IPMNs), particularly those after 5 years if surveillance, have not been fully evaluated in large studies. We analyzed incidences of IPMN-derived carcinoma and concomitant ductal adenocarcinoma (PDAC) over 20 years in a large population of patients. METHODS: We identified 1404 consecutive patients (52% female; mean age, 67.5 years) with a diagnosis of branch-duct IPMN, from 1994 through 2017, at the University of Tokyo in Japan...
August 29, 2019: Gastroenterology
https://read.qxmd.com/read/31477523/henry-t-lynch-md-january-4-1928-june-2-2019
#20
EDITORIAL
C Richard Boland
No abstract text is available yet for this article.
August 28, 2019: Gastroenterology
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