Mingjun Sun, Yexin Tong, Wei Yuan, Yunzhi Wang, Yan Pu, Wen Huang, Boqiong Lv, Chen Xu, Wei Jiang, Rongkui Luo, Rundong Fang, Shaoshuai Tang, Lei Ren, Jiachen Wang, Jinwen Feng, Cheng Sun, Kuntang Shen, Fuchu He, Yingyong Hou, Chen Ding
BACKGROUND & AIMS: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract, and it has high metastatic and recurrence rates. We aimed to characterize the proteomic features of GIST to understand biological processes and treatment vulnerabilities. METHODS: Quantitative proteomics and phosphoproteomics analyses were performed on 193 GIST patients to reveal the biological characteristics of GIST. Data-driven hypotheses were tested by performing functional experiments utilizing both GIST cell lines and xenograft mouse models...
November 21, 2023: Gastroenterology