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Gastroenterology

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https://read.qxmd.com/read/30872106/mechanical-stretch-increases-expression-of-cxcl1-in-liver-sinusoidal-endothelial-cells-to-recruit-neutrophils-generate-sinusoidal-microthombi-and-promote-portal-hypertension
#1
Moira B Hilscher, Tejasav Sehrawat, Juan Pablo Arab Verdugo, Zhutian Zeng, Jinhang Gao, Mengfei Liu, Enis Kostallari, Yandong Gao, Douglas A Simonetto, Usman Yaqoob, Sheng Cao, Alexander Revzin, Arthur Beyder, Rong Wang, Patrick S Kamath, Paul Kubes, Vijay H Shah
BACKGROUND & AIMS: Mechanical forces contribute to portal hypertension (PHTN) and fibrogenesis. We investigated the mechanisms by which forces are transduced by liver sinusoidal endothelial cells (LSECs) into pressure and matrix changes. METHODS: We isolated primary LSECs from mice and induced mechanical stretch with a Flexcell device, to recapitulate the pulsatile forces induced by congestion, and performed microarray and RNA-sequencing analyses to identify gene expression patterns associated with stretch...
March 11, 2019: Gastroenterology
https://read.qxmd.com/read/30872105/a-diet-low-in-red-and-processed-meat-does-not-reduce-rate-of-crohn-s-disease-flares
#2
L Albenberg, C M Brensinger, Q Wu, E Gilroy, M D Kappelman, R S Sandler, J D Lewis
BACKGROUND & AIMS: Diet may be an important factor in progression of Crohn's disease (CD). We performed a randomized controlled trial to determine whether reduced consumption of red and processed meats decreases the risk of symptomatic relapse of CD, analyzing results from the Food and Crohn's Disease Exacerbation Study (FACES) trial. METHODS: Adults with CD were recruited into the FACES trial from IBD Partners, an internet-based cohort of IBD patients, from November 2013 through June 2015...
March 11, 2019: Gastroenterology
https://read.qxmd.com/read/30872104/efficacy-of-budesonide-vs-fluticasone-for-initial-treatment-of-eosinophilic-esophagitis-in-a-randomized-controlled-trial
#3
Evan S Dellon, John T Woosley, Ashley Arrington, Sarah J McGee, Jacquelyn Covington, Susan E Moist, Jessica H Gebhart, Alexandra E Tylicki, Shiyan O Shoyoye, Christopher F Martin, Joseph A Galanko, John A Baron, Nicholas J Shaheen
BACKGROUND AND AIMS: Topical steroid treatments for eosinophilic esophagitis (EoE) include swallowed fluticasone from a multi-dose inhaler (MDI) or oral viscous budesonide (OVB) slurry, but the two have never been compared. We assessed whether OVB was more effective than MDI for initial treatment of patients with EoE. METHODS: In a double-blind, double-dummy trial, patients with a new diagnosis of EoE were randomly assigned to groups given 8 weeks of either OVB (1mg/4mL) twice daily plus a placebo inhaler (n=56) or fluticasone MDI (880 mcg) twice daily plus a placebo slurry (n=55)...
March 11, 2019: Gastroenterology
https://read.qxmd.com/read/30851304/unexpected-cause-of-abdominal-pain-and-genitourinary-symptoms
#4
Mohamad Mouchli, Mohammad Shakhatreh, Paul Yeaton
No abstract text is available yet for this article.
March 6, 2019: Gastroenterology
https://read.qxmd.com/read/30851303/zenker-s-diverticulum-per-oral-endoscopic-myotomy-techniques-changing-paradigms
#5
Olaya I Brewer Gutierrez, Yervant Ichkhanian, Marco Spadaccini, Kia Vosoughi, Alessandro Repici, Mouen A Khashab
No abstract text is available yet for this article.
March 6, 2019: Gastroenterology
https://read.qxmd.com/read/30851302/an-unusual-cause-of-chest-pain
#6
Fredy Nehme, Rami Atallah, William Palko
No abstract text is available yet for this article.
March 6, 2019: Gastroenterology
https://read.qxmd.com/read/30849319/penetration-of-the-esophageal-epithelium-by-dust-mite-antigen-in-patients-with-eosinophilic-esophagitis
#7
Anupama Ravi, Eric V Marietta, Debra M Geno, Jeffrey A Alexander, Joseph A Murray, David A Katzka
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849318/covering-the-cover-april-2019
#8
Andrew T Chan
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849317/vedolizumab-does-not-impair-sperm-dna-integrity-in-men-with-inflammatory-bowel-disease
#9
Anne Grosen, Mona Bungum, Christian Lodberg Hvas, Mette Julsgaard, Eugenia Cordelli, Jens Kelsen
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849316/individuals-with-advanced-adenomas-are-at-increased-risk-for-colorectal-cancer
#10
Resham Ramkissoon, Joseph C Anderson
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849315/how-to-write-an-effective-business-plan-in-medicine
#11
Amir Jazayeri, K T Park
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849314/acute-on-chronic-liver-failure-in-cirrhosis-requires-expedited-decision-for-liver-transplantation
#12
EDITORIAL
Vicente Arroyo
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849313/will-a-ppi-and-an-aspirin-keep-the-doctor-away-for-patients-with-barrett-s-esophagus
#13
EDITORIAL
Rebecca C Fitzgerald, Douglas A Corley
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849312/aspirin-does-it-have-a-role-for-hcc-chemoprevention
#14
Patrick Marquardt, Yujin Hoshida, Amit G Singal
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849311/how-to-promote-leadership-among-women-in-gi-lessons-learned-and-future-directions
#15
Monina Pascua, Tatyana Kushner, Zibing Woodward
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30844373/current-practicein-the-diagnosis-of-bile-acid-diarrhea
#16
EDITORIAL
Priya Vijayvargiya, Michael Camilleri
No abstract text is available yet for this article.
March 4, 2019: Gastroenterology
https://read.qxmd.com/read/30836096/gnai1-and-gnai3-reduce-colitis-associated-tumorigenesis-in-mice-by-blocking-il6-signaling-and-downregulating-expression-of-gnai2
#17
Zhi-Wei Li, Beicheng Sun, Ting Gong, Sheng Guo, Jianhua Zhang, Junlong Wang, Atsushi Sugawara, Meisheng Jiang, Junjun Yan, Alexandra Gurary, Xin Zhen, Bifeng Gao, Shu-Yuan Xiao, Wenlian Chen, Chi Ma, Chenjun Zhu, Christine Farrar, Owen T M Chan, Can Xin, Andrew Winnicki, John Winnicki, Mingxin Tang, Ryan Park, Mary Winnicki, Katrina Diener, Zhanwei Wang, Qicai Liu, Catherine H Chu, Peibin Yue, Lindsay Alpert, George S Hui, Peiwen Fei, James Turkson, Wentian Yang, Guangyu Wu, Ailin Tao, Joe W Ramos, Stefan Moisyadi, Randall F Holcombe, Wei Jia, Lutz Birnbaumer, Xiqiao Zhou, Wen-Ming Chu
BACKGROUND & AIMS: Interleukin 6 (IL6) and tumor necrosis factor (TNF) contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans. METHODS: B6;129 wild-type (control) or mice with disruption of Gnai1, Gnai2, and/or Gnai3 or conditional disruption of Gnai2 in CD11c+ or epithelial cells were given dextran sulfate sodium (DSS) to induce colitis followed by azoxymethane (AOM) to induce carcinogenesis; some mice were given an antibody against IL6...
March 2, 2019: Gastroenterology
https://read.qxmd.com/read/30836095/association-between-antibiotics-in-the-first-year-of-life-and-celiac-disease
#18
Stine Dydensborg Sander, Anne-Marie Nybo Andersen, Joseph A Murray, Øystein Karlstad, Steffen Husby, Ketil Størdal
BACKGROUND & AIMS: The intestinal microbiota is thought to be involved in pathogenesis of celiac disease, along with genetic variants and dietary gluten. The gut microbiota is strongly influenced by systemic antibiotics-especially in early life. We explored the association between exposure to a systemic antibiotic in the first year of life and risk of diagnosed celiac disease. METHODS: We performed an observational nationwide register-based cohort study. We included all children born in Denmark from 1995 through 2012 or Norway from 2004 through 2012...
March 2, 2019: Gastroenterology
https://read.qxmd.com/read/30836094/real-time-targeted-genome-profile-analysis-of-pancreatic-ductal-adenocarcinomas-identifies-genetic-alterations-that-might-be-targeted-with-existing-drugs-or-used-as-biomarkers
#19
Aatur D Singhi, Ben George, Joel R Greenbowe, Jon Chung, James Suh, Anirban Maitra, Samuel J Klempner, Andrew Hendifar, Javle M Milind, Talia Golan, Randall E Brand, Amer H Zureikat, Somak Roy, Alexa B Schrock, Vincent A Miller, Jeffrey S Ross, Siraj M Ali, Nathan Bahary
BACKGROUND AND AIMS: It has been a challenge to select treatment for patients with pancreatic ductal adenocarcinomas (PDACs) based on genome alterations. We performed targeted genomic profile analyses of a large number of PDACs to assess the full spectrum of actionable genomic alterations METHODS: We performed targeted genomic profile analyses of 3594 PDAC samples from an international cohort, including capture-based targeted genomic profiling of as many as 315 cancer-associated genes and intron regions of 28 genes that are rearranged in cancer cells...
March 2, 2019: Gastroenterology
https://read.qxmd.com/read/30836093/hcv-induced-epigenetic-changes-associated-with-liver-cancer-risk-persist-after-sustained-virologic-response
#20
Nourdine Hamdane, Frank Jühling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, François Habersetzer, Michel Doffoël, Tullio Piardi, Daniele Sommacale, Michio Imamura, Takuro Uchida, Hideki Ohdan, Hiroshi Aikata, Kazuaki Chayama, Tujana Boldanova, Patrick Pessaux, Bryan C Fuchs, Yujin Hoshida, Mirjam B Zeisel, François H T Duong, Thomas F Baumert
BACKGROUND AND AIMS: Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is reduced but not eliminated following a sustained virologic response (SVR) to direct-acting antiviral (DAA) agents, and risk is higher in patients with advanced fibrosis. We investigated HCV-induced epigenetic alterations that might affect risk for HCC after DAA treatment in patients and mice with humanized livers...
March 2, 2019: Gastroenterology
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