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Gastroenterology

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https://read.qxmd.com/read/31279872/sigmoid-derived-neovaginal-hemorrhage-in-a-transgender-patient
#1
Philip J Riddle, Farzin Rashti, Divya Ahuja
No abstract text is available yet for this article.
July 4, 2019: Gastroenterology
https://read.qxmd.com/read/31279871/endoscopic-radiologic-and-histologic-healing-with-vedolizumab-in-patients-with-active-crohn-s-disease
#2
Silvio Danese, William J Sandborn, Jean-Frédéric Colombel, Séverine Vermeire, Sarah C Glover, Jordi Rimola, Jenifer Siegelman, Stephen Jones, Jeffrey Bornstein, Brian G Feagan
BACKGROUND & AIMS: Vedolizumab is a gut-selective monoclonal antibody for the treatment of moderately to severely active Crohn's disease (CD). We performed a prospective study of endoscopic, radiologic, and histologic healing in patients with CD who received vedolizumab therapy. METHODS: We performed a phase 3b, open-label, single-group study of 101 patients with at least 3 months of active CD (a CD Activity Index [CDAI] score of 220-450, a simple endoscopic score for CD [SES-CD] of 7 or more, 1 or more mucosal ulcerations [identified by endoscopy], and failure of conventional therapy) from March 2015 through December 2017...
July 4, 2019: Gastroenterology
https://read.qxmd.com/read/31279870/effects-of-ustekinumab-on-histologic-disease-activity-in-patients-with-crohn-s-disease
#3
Katherine Li, Joshua R Friedman, Daphne Chan, Paul Pollack, Feifei Yang, Douglas Jacobstein, Carrie Brodmerkel, Christopher Gasink, Brian G Feagan, William J Sandborn, Paul Rutgeerts, Gert De Hertogh
BACKGROUND & AIMS: Although ustekinumab is an effective therapy for moderate to severe Crohn's disease (CD), its effects on the microscopic manifestations of CD are unknown. METHODS: We evaluated the effects of ustekinumab on histologic CD activity in an analysis of data from 251 participants in phase 3 induction and maintenance studies. Two endoscopic biopsies were collected at weeks 0, 8, and 44 from the ileum, splenic flexure, and rectum (18 biopsies from each patient)...
July 4, 2019: Gastroenterology
https://read.qxmd.com/read/31278901/prevention-of-biliary-cancer-with-statins-still-a-long-way-to-go
#4
Massimo Colombo, Federica Turati, Carlo La Vecchia
No abstract text is available yet for this article.
July 3, 2019: Gastroenterology
https://read.qxmd.com/read/31278900/43-year-old-female-presenting-with-chronic-abdominal-pain-weight-loss-and-a-palpable-abdominal-mass
#5
Cosman Camilo Mandujano Bejarano, Louisiana Rivera Valladares, Joseph Vazzana
No abstract text is available yet for this article.
July 3, 2019: Gastroenterology
https://read.qxmd.com/read/31260661/lanreotide-reduces-liver-growth-in-patients-with-polycystic-liver-disease-further-robust-evidences-but-not-the-end-of-the-story
#6
EDITORIAL
Temmerman Frederik, Nevens Frederik
No abstract text is available yet for this article.
June 28, 2019: Gastroenterology
https://read.qxmd.com/read/31260660/when-is-celiac-disease-celiac-disease
#7
EDITORIAL
Peter Hr Green, Stefano Guandalini
No abstract text is available yet for this article.
June 28, 2019: Gastroenterology
https://read.qxmd.com/read/31255654/a-unique-cause-of-gastric-polyposis
#8
Alyssa Anderson, Regina Plummer, James M Abraham
No abstract text is available yet for this article.
June 27, 2019: Gastroenterology
https://read.qxmd.com/read/31255653/met-signaling-overcomes-egfr-inhibition-in-normal-and-colorectal-cancer-stem-cells-causing-drug-resistance
#9
Sander P J Joosten, Tomohiro Mizutani, Marcel Spaargaren, Hans Clevers, Steven T Pals
No abstract text is available yet for this article.
June 27, 2019: Gastroenterology
https://read.qxmd.com/read/31255652/microbiome-signatures-associated-with-steatohepatitis-and-moderate-to-severe-fibrosis-in-children-with-nonalcoholic-fatty-liver-disease
#10
Jeffrey B Schwimmer, Jethro S Johnson, Jorge E Angeles, Cynthia Behling, Patricia H Belt, Ingrid Borecki, Craig Bross, Janis Durelle, Nidhi P Goyal, Gavin Hamilton, Mary L Holtz, Joel E Lavine, Makedonka Mitreva, Kimberly P Newton, Amy Pan, Pippa M Simpson, Claude B Sirlin, Erica Sodergren, Rahul Tyagi, Katherine P Yates, George Weinstock, Nita H Salzman
BACKGROUND & AIMS: The intestinal microbiome might affect development and severity of nonalcoholic fatty liver disease (NAFLD). We analyzed microbiomes of children with and without NAFLD. METHODS: We performed a prospective, observational, cross-sectional study of 87 children (8-17 years old) with biopsy-proven NAFLD and 37 children with obesity without NAFLD (controls). Fecal samples were collected and microbiome composition and functions were assessed using 16S rRNA amplicon sequencing and metagenomic shotgun sequencing...
June 27, 2019: Gastroenterology
https://read.qxmd.com/read/31255651/urrant-jelly-like-clot-induced-acute-pancreatitis
#11
Mihaela Horumbă, Alberto Larghi, Mihai Rimbaș
No abstract text is available yet for this article.
June 27, 2019: Gastroenterology
https://read.qxmd.com/read/31254503/treating-inflammatory-bowel-disease-with-diet-a-taste-test
#12
EDITORIAL
João Sabino, James Lewis, Jean-Fréderic Colombel
No abstract text is available yet for this article.
June 27, 2019: Gastroenterology
https://read.qxmd.com/read/31254502/challenges-in-the-pathophysiology-diagnosis-and-management-of-intestinal-fibrosis-in-inflammatory-bowel-disease
#13
Geert D'Haens, Florian Rieder, Brian G Feagan, Peter D R Higgins, Julian Panes, Christian Maaser, Gerhard Rogler, Mark Löwenberg, Robbert van der Voort, Massimo Pinzani, Laurent Peyrin-Biroulet, Silvio Danese
Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD) that is usually the consequence of chronic inflammation. Although the currently available anti-inflammatory therapies have had little impact on intestinal fibrosis in Crohn's disease (CD), increased understanding of the pathophysiology and the development of therapies targeting fibrogenic pathways hold promise for the future. One of the critical challenges is how reduction or reversal of intestinal fibrosis should be defined and measured in the setting of clinical trials and drug approval...
June 26, 2019: Gastroenterology
https://read.qxmd.com/read/31251929/gastroenterologist-level-identification-of-small-bowel-diseases-and-normal-variants-by-capsule-endoscopy-using-a-deep-learning-model
#14
Zhen Ding, Huiying Shi, Hao Zhang, Lingjun Meng, Mengke Fan, Chaoqun Han, Kun Zhang, Fanhua Ming, Xiaoping Xie, Hao Liu, Jun Liu, Rong Lin, Xiaohua Hou
BACKGROUND & AIMS: Capsule endoscopy has revolutionized investigation of the small bowel. However, this technique produces a video that is 8-10 hours long, so analysis is time consuming for gastroenterologists. Deep convolutional neural networks (CNNs) can recognize specific images among a large variety. We aimed to develop a CNN-based algorithm to assist in evaluation of small bowel capsule endoscopy (SB-CE) images. METHODS: We collected 113,426,569 images from 6970 patients who underwent SB-CE at 77 medical centers from July 2016 through July 2018...
June 25, 2019: Gastroenterology
https://read.qxmd.com/read/31251928/trends-in-mortality-from-extrahepatic-complications-in-patients-with-chronic-liver-disease-from-2007-through-2017
#15
Donghee Kim, Adeyinka C Adejumo, Eric R Yoo, Umair Iqbal, Andrew A Li, Edward A Pham, George Cholankeril, Jeffrey S Glenn, Aijaz Ahmed
BACKGROUND & AIMS: Trends of mortality associated with extrahepatic complications of chronic liver disease might be changing. We studied trends in mortality from extrahepatic complications of viral hepatitis, alcoholic liver disease (ALD), and nonalcoholic fatty liver disease in the United States (US). METHODS: We performed a population-based study using US Census and the National Center for Health Statistics mortality records, from 2007 through 2017. We identified trends in age-standardized mortality using joinpoint trend analysis with estimates of annual percentage change...
June 25, 2019: Gastroenterology
https://read.qxmd.com/read/31233735/editorial-there-is-something-about-gluten-will-science-sway-beliefs
#16
EDITORIAL
Emma P Halmos, Peter R Gibson
No abstract text is available yet for this article.
June 21, 2019: Gastroenterology
https://read.qxmd.com/read/31229495/imbalance-of-genes-encoding-natural-killer-immunoglobulin-like-receptors-and-human-leukocyte-antigen-in-patients-with-biliary-cancer
#17
Martin Cornillet, Hannes Jansson, Marie Schaffer, Laura Hertwig, Lena Berglin, Christine L Zimmer, Helene Johansson, Ewa Ellis, Bengt Isaksson, Faviel F Gonzalez-Galarza, Derek Middleton, Karl-Johan Malmberg, Ernesto Sparrelid, Niklas K Björkström
BACKGROUND & AIMS: Bile duct tumors are rare and have poor prognoses. Natural killer (NK) cells are frequent in human liver and infiltrate these tumors but do not control their progression. Responses of NK cells are regulated by natural killer immunoglobulin-like receptors (KIRs), which interact with HLA class I ligands. We aimed to characterize the features of the KIR gene loci and their ligands in patients with bile duct cancer (BDC). METHODS: We performed combined multi-dimensional characterization of genes that encode KIRs and their ligands in blood samples from patients with BDC from Sweden, followed for as long as 8 years after diagnosis (n=148), in 2 geographically matched cohorts of healthy individuals from Northern Europe (controls, n=204 and n=900), and in healthy individuals from 6 geographically unrelated populations (controls, n=2917)...
June 20, 2019: Gastroenterology
https://read.qxmd.com/read/31229494/expediting-drug-development-for-pediatric-inflammatory-bowel-disease-a-workshop-to-identify-barriers-and-move-forward
#18
Tara Altepeter, Ellen Wertheimer, Jessica J Lee
No abstract text is available yet for this article.
June 20, 2019: Gastroenterology
https://read.qxmd.com/read/31229493/superficially-deceiving-gastric-lesion-what-lies-beneath
#19
Inês Pita, Luís Pedro Afonso, Pedro Pimentel-Nunes
No abstract text is available yet for this article.
June 20, 2019: Gastroenterology
https://read.qxmd.com/read/31228446/colonoscopy-surveillance-intervals-for-small-non-advanced-adenomas-does-size-matter
#20
John W Birk, Joseph C Anderson
No abstract text is available yet for this article.
June 19, 2019: Gastroenterology
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