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Gastroenterology

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https://read.qxmd.com/read/30885780/ppard-and-interferon-gamma-promote-transformation-of-gastric-progenitor-cells-and-tumorigenesis-in-mice
#1
Xiangsheng Zuo, Yasunori Deguchi, Weiguo Xu, Yi Liu, Haiyan S Li, Daoyan Wei, Rui Tian, Weidong Chen, Min Xu, Yaying Yang, Shen Gao, Jonathan C Jaoude, Fuyao Liu, Sarah P Chrieki, Micheline J Moussalli, Mihai Gagea, Manu M Sebastian, Xiaofeng Zheng, Dongfeng Tan, Russell Broaddus, Jing Wang, Nadim J Ajami, Alton G Swennes, Stephanie S Watowich, Imad Shureiqi
BACKGROUND & AIMS: The peroxisome proliferator activated receptor delta (PPARD) regulates cell metabolism, proliferation, and inflammation and has been associated with gastric and other cancers. Villin-positive epithelial cells are a small population of quiescent gastric progenitor cells. We expressed PPARD from a villin promoter to investigate the role of these cells and PPARD in development of gastric cancer. METHODS: We analyzed gastric tissues from mice that express the Ppard (PPARD1 and PPARD2 mice) from a villin promoter, and mice that did not carry this transgene (controls), by histology and immunohistochemistry...
March 15, 2019: Gastroenterology
https://read.qxmd.com/read/30885779/tyrosine-and-glutamine-leucine-are-metabolic-markers-of-early-stage-colorectal-cancers
#2
Jiankang Li, Jing Li, Huan Wang, Lian-Wen Qi, Yimin Zhu, Maode Lai
No abstract text is available yet for this article.
March 15, 2019: Gastroenterology
https://read.qxmd.com/read/30885778/clip-closure-prevents-bleeding-after-endoscopic-resection-of-large-colon-polyps-in-a-randomized-trial
#3
Heiko Pohl, Ian S Grimm, Matthew T Moyer, Muhammad K Hasan, Douglas Pleskow, B Joseph Elmunzer, Mouen A Khashab, Omid Sanaei, Firas H Al-Kawas, Stuart R Gordon, Abraham Mathew, John M Levenick, Harry R Aslanian, Fadi Antaki, Daniel von Renteln, Seth D Crockett, Amit Rastogi, Jeffrey A Gill, Ryan J Law, Pooja A Elias, Maria Pellise, Michael B Wallace, Todd A Mackenzie, Douglas K Rex
BACKGROUND & AIMS: Bleeding is the most common severe complication after endoscopic mucosal resection of large colon polyps and is associated with significant morbidity and cost. We examined whether prophylactic closure of the mucosal defect with hemoclips after polyp resection reduces the risk of bleeding. METHODS: We performed a multicenter, randomized trial of patients with a large non-pedunculated colon polyp (≥20 mm) at 18 medical centers in North America and Spain from April 2013 through October 2017...
March 15, 2019: Gastroenterology
https://read.qxmd.com/read/30880022/genetic-factors-and-the-intestinal-microbiome-guide-development-of-microbe-based-therapies-for-inflammatory-bowel-diseases
#4
REVIEW
Louis J Cohen, Judy H Cho, Dirk Gevers, Hiutung Chu
The intestinal microbiota is a dynamic community of bacteria, fungi, and viruses that mediates mucosal homeostasis and physiology. Imbalances in the microbiome and aberrant immune responses to gut bacteria can disrupt homeostasis and are associated with inflammatory bowel diseases (IBD) in humans and colitis in mice. We review genetic variants associated with IBD and their effects on the intestinal microbiome, the immune response, and disease pathogenesis. The intestinal microbiome, which includes microbial antigens, adjuvants, and metabolic products, affects the development and function of the intestinal mucosa and inflammatory responses in the gut...
March 14, 2019: Gastroenterology
https://read.qxmd.com/read/30880021/goodbye-for-good-stepping-away-from-recurrence
#5
LETTER
Amika Moro, Keita Okubo, Kazunari Sasaki
No abstract text is available yet for this article.
March 14, 2019: Gastroenterology
https://read.qxmd.com/read/30880020/colon-cancer-risk-and-vaca-toxin-of-helicobacter-pylori
#6
LETTER
Antonio Ponzetto, Natale Figura
No abstract text is available yet for this article.
March 14, 2019: Gastroenterology
https://read.qxmd.com/read/30880019/recurrence-of-primary-biliary-cholangitis-after-liver-transplantation-is-tacrolimus-really-worse-than-other-drugs
#7
LETTER
Michel Rayar, Edouard Bardou-Jacquet
No abstract text is available yet for this article.
March 14, 2019: Gastroenterology
https://read.qxmd.com/read/30880018/re-effects-of-long-term-norfloxacin-therapy-in-patients-with-advanced-cirrhosis
#8
LETTER
Andrea Lombardi, Mario U Mondelli, Raffaele Bruno
No abstract text is available yet for this article.
March 14, 2019: Gastroenterology
https://read.qxmd.com/read/30878469/aga-clinical-practice-update-on-interaction-between-oral-direct-acting-antivirals-daas-for-chronic-hepatitis-c-infection-and-hepatocellular-carcinoma-expert-review
#9
REVIEW
Amit G Singal, Joseph K Lim, Fasiha Kanwal
No abstract text is available yet for this article.
March 13, 2019: Gastroenterology
https://read.qxmd.com/read/30878468/ccne1-overexpression-causes-chromosome-instability-in-liver-cells-and-liver-tumor-development-in-mice
#10
Khaled Aziz, Jazeel F Limzerwala, Ines Sturmlechner, Erin Hurley, Cheng Zhang, Karthik B Jeganathan, Grace Nelson, Steve Bronk, Raul Fierro Velasco, Erik-Jan van Deursen, Daniel R O'Brien, Jean-Pierre A Kocher, Sameh A Youssef, Janine H van Ree, Alain de Bruin, Hilda van den Bos, Diana C J Spierings, Floris Foijer, Bart van de Sluis, Lewis R Roberts, Gregory Gores, Hu Li, Jan M van Deursen
BACKGROUND & AIMS: The CCNE1 locus, which encodes cyclin E1, is amplified in many types of cancer cells and is activated in hepatocellular carcinomas (HCCs) from patients infected with hepatitis B virus or adeno-associated virus type 2, due to integration of the virus nearby. We investigated cell cycle and oncogenic effects of cyclin E1 overexpression in tissues of mice. METHODS: We generated mice with doxycycline-inducible expression of Ccne1 (Ccne1T mice) and activated overexpression of cyclin E1 from age 3 weeks onwards...
March 13, 2019: Gastroenterology
https://read.qxmd.com/read/30872106/mechanical-stretch-increases-expression-of-cxcl1-in-liver-sinusoidal-endothelial-cells-to-recruit-neutrophils-generate-sinusoidal-microthombi-and-promote-portal-hypertension
#11
Moira B Hilscher, Tejasav Sehrawat, Juan Pablo Arab Verdugo, Zhutian Zeng, Jinhang Gao, Mengfei Liu, Enis Kostallari, Yandong Gao, Douglas A Simonetto, Usman Yaqoob, Sheng Cao, Alexander Revzin, Arthur Beyder, Rong Wang, Patrick S Kamath, Paul Kubes, Vijay H Shah
BACKGROUND & AIMS: Mechanical forces contribute to portal hypertension (PHTN) and fibrogenesis. We investigated the mechanisms by which forces are transduced by liver sinusoidal endothelial cells (LSECs) into pressure and matrix changes. METHODS: We isolated primary LSECs from mice and induced mechanical stretch with a Flexcell device, to recapitulate the pulsatile forces induced by congestion, and performed microarray and RNA-sequencing analyses to identify gene expression patterns associated with stretch...
March 11, 2019: Gastroenterology
https://read.qxmd.com/read/30872105/a-diet-low-in-red-and-processed-meat-does-not-reduce-rate-of-crohn-s-disease-flares
#12
L Albenberg, C M Brensinger, Q Wu, E Gilroy, M D Kappelman, R S Sandler, J D Lewis
BACKGROUND & AIMS: Diet may be an important factor in progression of Crohn's disease (CD). We performed a randomized controlled trial to determine whether reduced consumption of red and processed meats decreases the risk of symptomatic relapse of CD, analyzing results from the Food and Crohn's Disease Exacerbation Study (FACES) trial. METHODS: Adults with CD were recruited into the FACES trial from IBD Partners, an internet-based cohort of IBD patients, from November 2013 through June 2015...
March 11, 2019: Gastroenterology
https://read.qxmd.com/read/30872104/efficacy-of-budesonide-vs-fluticasone-for-initial-treatment-of-eosinophilic-esophagitis-in-a-randomized-controlled-trial
#13
Evan S Dellon, John T Woosley, Ashley Arrington, Sarah J McGee, Jacquelyn Covington, Susan E Moist, Jessica H Gebhart, Alexandra E Tylicki, Shiyan O Shoyoye, Christopher F Martin, Joseph A Galanko, John A Baron, Nicholas J Shaheen
BACKGROUND AND AIMS: Topical steroid treatments for eosinophilic esophagitis (EoE) include swallowed fluticasone from a multi-dose inhaler (MDI) or oral viscous budesonide (OVB) slurry, but the two have never been compared. We assessed whether OVB was more effective than MDI for initial treatment of patients with EoE. METHODS: In a double-blind, double-dummy trial, patients with a new diagnosis of EoE were randomly assigned to groups given 8 weeks of either OVB (1mg/4mL) twice daily plus a placebo inhaler (n=56) or fluticasone MDI (880 mcg) twice daily plus a placebo slurry (n=55)...
March 11, 2019: Gastroenterology
https://read.qxmd.com/read/30851304/unexpected-cause-of-abdominal-pain-and-genitourinary-symptoms
#14
Mohamad Mouchli, Mohammad Shakhatreh, Paul Yeaton
No abstract text is available yet for this article.
March 6, 2019: Gastroenterology
https://read.qxmd.com/read/30851303/zenker-s-diverticulum-per-oral-endoscopic-myotomy-techniques-changing-paradigms
#15
Olaya I Brewer Gutierrez, Yervant Ichkhanian, Marco Spadaccini, Kia Vosoughi, Alessandro Repici, Mouen A Khashab
No abstract text is available yet for this article.
March 6, 2019: Gastroenterology
https://read.qxmd.com/read/30851302/an-unusual-cause-of-chest-pain
#16
Fredy Nehme, Rami Atallah, William Palko
No abstract text is available yet for this article.
March 6, 2019: Gastroenterology
https://read.qxmd.com/read/30849319/penetration-of-the-esophageal-epithelium-by-dust-mite-antigen-in-patients-with-eosinophilic-esophagitis
#17
Anupama Ravi, Eric V Marietta, Debra M Geno, Jeffrey A Alexander, Joseph A Murray, David A Katzka
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849318/covering-the-cover-april-2019
#18
Andrew T Chan
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849317/vedolizumab-does-not-impair-sperm-dna-integrity-in-men-with-inflammatory-bowel-disease
#19
Anne Grosen, Mona Bungum, Christian Lodberg Hvas, Mette Julsgaard, Eugenia Cordelli, Jens Kelsen
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
https://read.qxmd.com/read/30849316/individuals-with-advanced-adenomas-are-at-increased-risk-for-colorectal-cancer
#20
Resham Ramkissoon, Joseph C Anderson
No abstract text is available yet for this article.
March 5, 2019: Gastroenterology
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