journal
https://read.qxmd.com/read/32980345/intestinal-inflammation-modulates-the-expression-of-ace2-and-tmprss2-and-potentially-overlaps-with-the-pathogenesis-of-sars-cov-2-related-disease
#1
Mayte Suárez-Fariñas, Minami Tokuyama, Gabrielle Wei, Ruiqi Huang, Alexandra Livanos, Divya Jha, Anais Levescot, Haritz Irizar, Roman Kosoy, Sascha Cording, Wenhui Wang, Bojan Losic, Ryan Ungaro, Antonio Di'Narzo, Gustavo Martinez-Delgado, Maria Suprun, Michael J Corley, Aleksandar Stojmirovic, Sander M Houten, Lauren Peters, Mark Curran, Carrie Brodmerkel, Jacqueline Perrigoue, Joshua R Friedman, Ke Hao, Eric E Schadt, Jun Zhu, Huaibin M Ko, Judy Cho, Marla C Dubinsky, Bruce E Sands, Lishomwa Ndhlovu, Nadine Cerf-Bensusan, Andrew Kasarskis, Jean Frederic Colombel, Noam Harpaz, Carmen Argmann, Saurabh Mehandru
BACKGROUND AND AIMS: The presence of gastrointestinal symptoms and high levels of viral RNA in the stool suggest active Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) replication within enterocytes. METHODS: Here, in multiple, large cohorts of patients with inflammatory bowel disease (IBD), we have studied the intersections between Coronavirus Disease 2019 (COVID-19), intestinal inflammation and IBD treatment. RESULTS: A striking expression of ACE2 on the small bowel enterocyte brush border supports intestinal infectivity by SARS-CoV-2...
September 24, 2020: Gastroenterology
https://read.qxmd.com/read/32980344/effects-of-early-placement-of-transjugular-portosystemic-shunts-in-patients-with-high-risk-acute-variceal-bleeding-a-meta-analysis-of-individual-patient-data
#2
Oana Nicoară-Farcău, Guohong Han, Marika Rudler, Debora Angrisani, Alberto Monescillo, Ferran Torres, Georgina Casanovas, Jaime Bosch, Yong Lv, Dominique Thabut, Daiming Fan, Virginia Hernández-Gea, Juan Carlos García-Pagán, Christophe Bureau, Juan G Abraldes, Frederik Nevens, Karel Caca, Wim Laleman, Beate Appenrodt, Angelo Luca, Jean Pierre Vinel, Joachim Mössner, Marco Di Pascoli, Alexander Zipprich, Tilman Sauerbruch, Francisco Martinez-Lagares, Luis Ruiz-Del-Arbol, Angel Sierra, Clemencia Guevara, Elena Jimenez, Jose Miguel Marrero, Enrique Buceta, Juan Sanchez, Ana Castellot, Monica Penate, Ana Cruz, Elena Pena, Bogdan Procopet, Álvaro Giráldez, Lucio Amitrano, Candid Villanueva, Luis Ibañez-Samaniego, Gilberto Silva-Junior, Javier Martinez, Joan Genescà, Jonel Trebicka, Elba Llop, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise L Gluud, Carlos Noronha Ferreira, Rafael Barcelo, Nuria Cañete, Manuel Rodríguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Gronbaek, Manuel Hernández-Guerra, Romano Sassatelli, Alessandra Dell'Era, Marco Senzolo, Manuel Romero-Gómez, Meritxell Casas, Helena Masnou, Massimo Primignani, Aleksander Krag, Jose Luis Calleja, Christian Jansen, Marie Angèle Robic, Irene Conejo, Maria-Vega Catalina, Agustin Albillos, Edilmar Alvarado, Maria Anna Guardascione, Marcel Tanțău, Luo Zuo, Xuan Zhu, Jianbo Zhao, Hui Xue, Zaibo Jiang, Yuzheng Zhuge, Chunqing Zhang, Junhui Sun, Pengxu Ding, Weixin Ren, Yingchun Li, Kewei Zhang, Wenguang Zhang, Chuangye He, Jiawei Zhong, Qifeng Peng, Fuquan Ma, Junyang Luo, Ming Zhang, Guangchuan Wang, Minhuang Sun, Junjiao Dong, Wei Bai, Wengang Guo, Qiuhe Wang, Xulong Yuan, Zhengyu Wang, Tianlei Yu, Bohan Luo, Xiaomei Li, Jie Yuan, Na Han, Ying Zhu, Jing Niu, Kai Li, Zhanxin Yin, Yongzhan Nie, Petra Fischer, Horia Ștefănescu, Andreea Pop, Stig B Laursen, Fanny Turon, Anna Baiges, José Ferrusquía-Acosta, Marta Magaz, Eira Cerda, Luis Tellez, Giulia Allegretti, Guilherme Macedo, David Haldrup, Patricia Santos, Miguel Moura, Daniela Reis, Liliane Meireles, Patricia Sousa, Paula Alexandrino, Carmen Navascues, Salvador Augustin, Vincenzo La Mura, Rafael Bañares, Raquel Diaz, Marta López Gómez, Cristina Ripoll
BACKGROUND & AIMS: Compared with drugs plus endoscopy, placement of transjugular portosystemic shunt within 72 hrs of admission to the hospital (early or preventive TIPS, also called preemptive TIPS) increases the proportion of high-risk patients with cirrhosis and acute variceal bleeding who survive for 1 year. However, the benefit of preemptive TIPS is less clear for patients with a Child-Pugh score of B and active bleeding (CP-B+AB). We performed a individual data meta-analysis to assess the efficacy of preemptive TIPS in these patients and identify factors associated with reduced survival of patients receiving preemptive TIPS...
September 24, 2020: Gastroenterology
https://read.qxmd.com/read/32980343/sympathetic-input-to-multiple-cell-types-in-mouse-and-human-colon-produces-region-specific-responses
#3
Kristen M Smith-Edwards, Brian S Edwards, Christina M Wright, Sabine Schneider, Kimberly A Meerschaert, Lindsay L Ejoh, Sarah A Najjar, Marthe J Howard, Kathryn M Albers, Robert O Heuckeroth, Brian M Davis
BACKGROUND & AIMS: The colon is innervated by intrinsic and extrinsic neurons that coordinate functions necessary for digestive health. Sympathetic input suppresses colon motility by acting on intrinsic myenteric neurons, but the extent of sympathetic-induced changes on large-scale network activity in myenteric circuits has not been determined. Compounding the complexity of sympathetic function, there is evidence that sympathetic transmitters can regulate activity in non-neuronal cells (such as enteric glia and innate immune cells)...
September 24, 2020: Gastroenterology
https://read.qxmd.com/read/32980342/effect-of-acid-suppressants-on-the-risk-of-covid-19-a-propensity-score-matched-study-using-uk-biobank-acid-suppressants-and-the-risk-of-covid-19
#4
Xiude Fan, Zhengwen Liu, Tatsunori Miyata, Srinivasan Dasarathy, Daniel M Rotroff, Laura E Nagy, Xiaoqin Wu, Kyle L Poulsen
No abstract text is available yet for this article.
September 24, 2020: Gastroenterology
https://read.qxmd.com/read/32985980/covering-the-cover
#5
Andrew T Chan, Christopher S Williams
No abstract text is available yet for this article.
September 23, 2020: Gastroenterology
https://read.qxmd.com/read/32979356/predicting-outcomes-in-pediatric-crohn-s-disease-for-management-optimization-systematic-review-and-consensus-statements-from-pibd-ahead-program
#6
Amanda Ricciuto, Martine Aardoom, Esther Orlanski Meyer, Dan Navon, Nicholas Carman, Marina Aloi, Jiri Bronsky, Jan Däbritz, Marla Dubinsky, Séamus Hussey, Peter Lewindon, Javier Martin De Carpi, Víctor Manuel Navas-López, Marina Orsi, Frank M Ruemmele, Richard K Russell, Gabor Veres, Thomas D Walters, David C Wilson, Thomas Kaiser, Lissy de Ridder, Dan Turner, Anne M Griffiths
BACKGROUND AND AIMS: A better understanding of prognostic factors within the heterogeneous spectrum of pediatric Crohn's disease (CD) should improve patient management and reduce complications. We aimed to identify evidence-based predictors of outcomes with the goal of optimizing individual patient management. METHODS: A survey of 202 experts in pediatric CD identified and prioritized adverse outcomes to be avoided. A systematic review of the literature with meta-analysis, when possible, was performed to identify clinical studies that investigated predictors of these outcomes...
September 23, 2020: Gastroenterology
https://read.qxmd.com/read/32979355/artificial-intelligence-system-to-determine-risk-of-t1-colorectal-cancer-metastasis-to-lymph-node
#7
Shin-Ei Kudo, Katsuro Ichimasa, Benjamin Villard, Yuichi Mori, Masashi Misawa, Shoichi Saito, Kinichi Hotta, Yutaka Saito, Takahisa Matsuda, Kazutaka Yamada, Toshifumi Mitani, Kazuo Ohtsuka, Akiko Chino, Daisuke Ide, Kenichiro Imai, Yoshihiro Kishida, Keiko Nakamura, Yasumitsu Saiki, Masafumi Tanaka, Shu Hoteya, Satoshi Yamashita, Yusuke Kinugasa, Masayoshi Fukuda, Toyoki Kudo, Hideyuki Miyachi, Fumio Ishida, Hayato Itoh, Masahiro Oda, Kensaku Mori
BACKGROUND AIMS: In accordance with guidelines, most patients with T1 colorectal cancers (CRC) undergo surgical resection with lymph node dissection, despite the low incidence (∼10%) of metastasis to lymph node. To reduce unnecessary surgical resections, we used artificial intelligence to build a model to identify T1 colorectal tumors at risk for metastasis to lymph node and validated the model in a separate set of patients. METHODS: We collected data from 3134 patients with T1 CRC treated at 6 hospitals in Japan from April 1997 through September 2017 (training cohort)...
September 23, 2020: Gastroenterology
https://read.qxmd.com/read/32976826/predicting-outcomes-in-pediatric-ulcerative-colitis-for-management-optimization-systematic-review-and-consensus-statements-from-pibd-ahead-program
#8
Esther Orlanski Meyer, Martine Aardoom, Amanda Ricciuto, Dan Navon, Nicholas Carman, Marina Aloi, Jiri Bronsky, Jan Däbritz, Marla Dubinsky, Séamus Hussey, Peter Lewindon, Javier Martin De Carpi, Víctor Manuel Navas-López, Marina Orsi, Frank M Ruemmele, Richard K Russell, Gabor Veres, Thomas D Walters, David C Wilson, Thomas Kaiser, Lissy de Ridder, Anne Griffiths, Dan Turner
BACKGROUND AND AIMS: A better understanding of prognostic factors in ulcerative colitis (UC) could improve patient management and reduce complications. We aimed to identify evidence-based predictors for outcomes in pediatric UC, which may be used to optimize treatment algorithms. METHODS: Potential outcomes worthy of prediction in UC were determined by surveying 202 experts in pediatric UC. A systematic review of the literature, with selected meta-analysis, was performed to identify studies that investigated predictors for these outcomes...
September 22, 2020: Gastroenterology
https://read.qxmd.com/read/32971136/reply-to-gastro-d-20-01763-setting-the-record-straight-on-the-performance-and-safety-of-nucleic-acid-polymers
#9
LETTER
Andrew Vaillant
No abstract text is available yet for this article.
September 21, 2020: Gastroenterology
https://read.qxmd.com/read/32971135/reply-to-gastro-d-20-01116
#10
LETTER
Ka Shing Cheung, Wai K Leung
No abstract text is available yet for this article.
September 21, 2020: Gastroenterology
https://read.qxmd.com/read/32966824/colorectal-cancer-screening-in-the-covid-19-era
#11
EDITORIAL
Evelien Dekker, Han-Mo Chiu, Iris Lansdorp-Vogelaar, Luis Ernesto Caro, Jason A Dominitz, Stephen Halloran, Cesare Hassan, Julia Ismael, Rodrigo Jover, Michal F Kaminski, Tim Kortlever, Ernst J Kuipers, Theodore R Levin, Takahisa Matsuda, Dominika Novak Mlakar, Lix A R Oliveira, Susan Parry, Linda Rabeneck, Matthew Rutter, Roque Sáenz, Carlo Senore, Graeme P Young, Ning Zhang
No abstract text is available yet for this article.
September 20, 2020: Gastroenterology
https://read.qxmd.com/read/32961246/defining-endpoints-and-biomarkers-in-inflammatory-bowel-disease-moving-the-needle-through-clinical-trial-design
#12
Maria T Abreu, William J Sandborn
No abstract text is available yet for this article.
September 19, 2020: Gastroenterology
https://read.qxmd.com/read/32956680/ddit4-licenses-only-healthy-cells-to-proliferate-during-injury-induced-metaplasia
#13
Zhi-Feng Miao, Jing-Xu Sun, Mahliyah Adkins-Threats, Min-Jiao Pang, Jun-Hua Zhao, Xin Wang, Kai-Wen Tang, Zhen-Ning Wang, Jason C Mills
BACKGROUND AND AIMS: In stomach, metaplasia can arise from differentiated chief cells that become mitotic via paligenosis, a stepwise program. In paligenosis, mitosis initiation requires reactivation of the cellular energy hub mTORC1 after initial mTORC1 suppression by DNA damage induced transcript 4 (DDIT4 aka REDD1). Here, we use DDIT4-deficient mice and human cells to study how metaplasia increases tumorigenesis risk. METHODS: A tissue microarray of human gastric tissue specimens was analyzed by immunohistochemistry for DDIT4...
September 18, 2020: Gastroenterology
https://read.qxmd.com/read/32956679/population-level-configurations-of-gut-mycobiome-across-six-ethnicities-in-urban-and-rural-china
#14
Yang Sun, Tao Zuo, Chun Pan Cheung, Wenxi Gu, Yating Wan, Fen Zhang, Nan Chen, Hui Zhan, Yun Kit Yeoh, Junkun Niu, Yan Du, Fengrui Zhang, Yunling Wen, Jun Yu, Joseph Jy Sung, Paul Ks Chan, Francis Kl Chan, Kunhua Wang, Siew C Ng, Yinglei Miao
BACKGROUND & AIMS: Beyond bacteria, the human gastrointestinal tract is host to a vast diversity of fungi, collectively known as the gut mycobiome. Little is known of the impact of geography, ethnicity and urbanization on the gut mycobiome at a large population level. We aim to delineate the variation of human gut mycobiome and its association with host factors, environmental factors and diets. METHODS: Using shotgun metagenomic sequencing, we profiled and compared the fecal mycobiome of 942 healthy individuals across different geographic regions in China (Hong Kong and Yunnan), spanning six ethnicities, Han, Zang, Bai, Hani, Dai, and Miao (including both urban and rural residents to each ethnicity)...
September 18, 2020: Gastroenterology
https://read.qxmd.com/read/32950522/moving-towardsimpact-an-introduction-to-implementation-science-for-gastroenterologists-and-hepatologists
#15
EDITORIAL
Shari S Rogal, Byron J Powell, Matthew Chinman
No abstract text is available yet for this article.
September 17, 2020: Gastroenterology
https://read.qxmd.com/read/32950521/moderate-inter-observer-agreement-among-pathologists-in-differentiation-of-sessile-serrated-from-hyperplastic-polyps
#16
Sreekar Vennelaganti, Miriam Cuatrecasas, Prashanth Vennalaganti, Kevin F Kennedy, Sachin Srinivasan, Deepa T Patil, Thomas Plesec, Angel Lanas, Carlos Hörndler, Nevene Andraws, Rachel Cherian, Sharad Mathur, Cesare Hassan, Alessandro Repici, Dagmar Klotz, Eva Musulen, Mauro Risio, Antoni Castells, Neil Gupta, Prateek Sharma
No abstract text is available yet for this article.
September 17, 2020: Gastroenterology
https://read.qxmd.com/read/32950520/epidemiology-presentation-and-diagnosis-of-celiac-disease
#17
REVIEW
Benjamin Lebwohl, Alberto Rubio-Tapia
The incidence of celiac disease is increasing, partly due to improved recognition of, and testing for, the disease. The rise in incidence is also due to a real increase of this immune-based disorder, independent of disease detection. The reasons for this true rise in recent decades are unknown but may be related to environmental factors that may promote loss of tolerance to dietary gluten. Strategies to reduce the development of celiac disease have not been proven successful in randomized trials, but the quantity of early-life gluten exposure has been a major focus of prevention efforts...
September 17, 2020: Gastroenterology
https://read.qxmd.com/read/32949568/ambulatory-reflux-monitoring-guides-proton-pump-inhibitor-discontinuation-in-patients-with-gastroesophageal-reflux-symptoms-a-clinical-trial
#18
Rena Yadlapati, Melina Masihi, C Prakash Gyawali, Dustin A Carlson, Peter J Kahrilas, Billy Darren Nix, Anand Jain, Joseph R Triggs, Michael F Vaezi, Leila Kia, Alexander Kaizer, John E Pandolfino
BACKGROUND & AIMS: Proton pump inhibitor (PPI) therapy fails to provide adequate symptom control in up to 50% of patients with gastroesophageal reflux symptoms. While a proportion do not require ongoing PPI therapy, a diagnostic approach to identify candidates appropriate for PPI cessation is not available. This study aimed to examine the clinical utility of prolonged wireless reflux monitoring to predict ability to discontinue PPI. METHODS: This double-blinded clinical trial performed over three years at two centers enrolled adults with troublesome esophageal symptoms of heartburn, regurgitation, and/or chest pain and inadequate PPI response...
September 16, 2020: Gastroenterology
https://read.qxmd.com/read/32946906/an-unusual-cause-of-small-intestinal-ulceration
#19
Eliza Flanagan, Damian Dowling, Richard A Standish
No abstract text is available yet for this article.
September 15, 2020: Gastroenterology
https://read.qxmd.com/read/32946905/intestinal-microbiome-modulation-during-covid-19-another-chance-to-manage-the-disease
#20
LETTER
Antonio Tursi, Alfredo Papa
No abstract text is available yet for this article.
September 15, 2020: Gastroenterology
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