journal
https://read.qxmd.com/read/36966943/proteomic-profiling-of-colorectal-adenomas-identifies-a-predictive-risk-signature-for-development-of-metachronous-advanced-colorectal-neoplasia
#1
JOURNAL ARTICLE
Jacob Mathias Bech, Thilde Terkelsen, Annette Snejbjerg Bartels, Fabian Coscia, Sophia Doll, Siqi Zhao, Zhaojun Zhang, Nils Brünner, Jan Lindebjerg, Gunvor Iben Madsen, Xiangdong Fang, Matthias Mann, José Manuel Afonso Moreira
BACKGROUND & AIMS: Colonic adenomatous polyps, or adenomas, are frequent precancerous lesions and the origin of most cases of colorectal adenocarcinoma. However, we know from epidemiological studies that although most colorectal cancers originate from adenomas, only a small fraction of adenomas (3-5%) ever progress to cancer. At present, there are no molecular markers to guide follow-up surveillance programs. METHODS: We profiled by mass spectrometry (MS)-based proteomics combined with machine learning analysis a selected cohort of formalin fixed paraffin embedded HG adenomas with long clinical follow-up, collected as part of the Danish national screening program...
March 24, 2023: Gastroenterology
https://read.qxmd.com/read/36966942/liver-sol-in-a-case-of-colon-cancer-a-red-herring
#2
JOURNAL ARTICLE
Srikanth Gadiyaram, Murugappan Nachiappan, Dinesh Kini
No abstract text is available yet for this article.
March 24, 2023: Gastroenterology
https://read.qxmd.com/read/36966941/arbm101-methanobactin-sb2-drains-excess-liver-copper-via-biliary-excretion-in-wilson-disease-rats
#3
JOURNAL ARTICLE
Claudia Einer, Ditte Emilie Munk, Eok Park, Banu Akdogan, Judith Nagel, Josef Lichtmannegger, Carola Eberhagen, Tamara Rieder, Mikkel H Vendelbo, Bernhard Michalke, Ralf Wimmer, Andreas Blutke, Annette Feuchtinger, Philip Dershwitz, Ana A DiSpirito, Tawhidul Islam, Rui E Castro, Byong-Keol Min, TaeWon Kim, Seoyoung Choi, Dasol Kim, Chunwon Jung, Hongjae Lee, Dongsik Park, Weonbin Im, So-Young Eun, You-Hee Cho, Jeremy D Semrau, Cecília M P Rodrigues, Simon Hohenester, Thomas Damgaard Sandahl, Alan A DiSpirito, Hans Zischka
BACKGROUND: Excess copper causes hepatocyte death in hereditary Wilson disease (WD). Current WD treatments by copper-binding chelators may gradually reduce copper overload; they fail, however, to bring hepatic copper close to normal physiological levels. Consequently, lifelong daily dose regimens are required to hinder disease progression. This may result in severe issues due to non-adherence or unwanted drug reactions, but also in drug switching and ultimate treatment failures. STUDY AIMS: To comparatively test bacteria-derived copper binding agents - methanobactins (MBs) - for efficient liver copper depletion in WD rats, as well as their safety and effect duration...
March 24, 2023: Gastroenterology
https://read.qxmd.com/read/36966940/a-pseudo-gastric-bubble
#4
JOURNAL ARTICLE
Yi-Ning Lo, Juei-Seng Wu, Hsueh-Chien Chiang
No abstract text is available yet for this article.
March 24, 2023: Gastroenterology
https://read.qxmd.com/read/36965742/sox9-a-key-regulator-of-gastric-stem-cell-behaviour-driving-cancer-initiation
#5
EDITORIAL
Hui Yi Grace Lim, Nick Barker
No abstract text is available yet for this article.
March 23, 2023: Gastroenterology
https://read.qxmd.com/read/36965741/an-unusual-cause-of-acute-cholecystitis
#6
JOURNAL ARTICLE
Ping-Hung Ko, Chih-Wei Tseng
No abstract text is available yet for this article.
March 23, 2023: Gastroenterology
https://read.qxmd.com/read/36965740/an-unusual-finding-on-ct-in-a-patient-with-iron-deficiency-anemia
#7
JOURNAL ARTICLE
Hailong Zhang, Jiahao Fan, Qingliang Zhu
No abstract text is available yet for this article.
March 23, 2023: Gastroenterology
https://read.qxmd.com/read/36965739/an-unusual-case-of-anal-pain-with-intense-metabolic-activity-of-the-internal-anal-sphincter
#8
JOURNAL ARTICLE
Riccardo Caccia, Massimo Castellani, Guido Basilisco
No abstract text is available yet for this article.
March 23, 2023: Gastroenterology
https://read.qxmd.com/read/36959022/correction
#9
(no author information available yet)
No abstract text is available yet for this article.
March 21, 2023: Gastroenterology
https://read.qxmd.com/read/36948425/next-generation-farnesoid-x-receptor-agonists-in-nash-treatment-are-we-there-yet
#10
JOURNAL ARTICLE
Brian J DeBosch
No abstract text is available yet for this article.
March 20, 2023: Gastroenterology
https://read.qxmd.com/read/36948424/randomized-trial-of-facilitated-adherence-to-screening-colonoscopy-versus-sequential-fecal-based-blood-test
#11
JOURNAL ARTICLE
Ann G Zauber, Sidney J Winawer, Michael J O'Brien, Glenn M Mills, John I Allen, Andrew D Feld, Paul A Jordan, Martin Fleisher, Irene Orlow, Reinier G S Meester, Iris Lansdorp-Vogelaar, Carolyn M Rutter, Amy B Knudsen, Margaret Mandelson, Aasma Shaukat, Robin B Mendelsohn, Anne I Hahn, Stephanie M Lobaugh, Brittany Soto Palmer, Victoria Serrano, Julie R Kumar, Sara E Fischer, Jennifer C Chen, Sharon Bayuga-Miller, Deborah Kuk, Kelli O'Connell, Timothy R Church
BACKGROUND AND AIMS: Colorectal cancer (CRC) screening guidelines include screening-colonoscopy and sequential high sensitivity fecal occult blood testing (HSgFOBT), with expectation of similar effectiveness based on the assumption of similar high adherence. However, adherence to screening-colonoscopy compared to sequential HSgFOBT has not been reported. In this randomized clinical trial, we assessed adherence and pathology findings for a single screening-colonoscopy versus sequential and non-sequential HSgFOBT...
March 20, 2023: Gastroenterology
https://read.qxmd.com/read/36940777/impact-of-screening-related-sigmoidoscopy-on-the-incidence-and-mortality-of-colorectal-cancer
#12
JOURNAL ARTICLE
Nauzer Forbes
No abstract text is available yet for this article.
March 18, 2023: Gastroenterology
https://read.qxmd.com/read/36940776/disposable-elevator-caps-reduce-microbial-contamination-after-ercp
#13
JOURNAL ARTICLE
Mark Hanscom
No abstract text is available yet for this article.
March 18, 2023: Gastroenterology
https://read.qxmd.com/read/36940775/can-microbes-and-their-components-prevent-growth-failure-caused-by-malnutrition
#14
JOURNAL ARTICLE
Eytan Wine
No abstract text is available yet for this article.
March 18, 2023: Gastroenterology
https://read.qxmd.com/read/36933624/is-the-quantification-of-interstitial-cells-of-cajal-in-gastric-biopsies-in-patients-with-gastroparesis-ready-for-prime-time
#15
JOURNAL ARTICLE
Michael Camilleri, Jan Tack
No abstract text is available yet for this article.
March 16, 2023: Gastroenterology
https://read.qxmd.com/read/36933623/onco-microbial-community-profiling-identifies-clinico-molecular-and-prognostic-subtypes-of-colorectal-cancer
#16
JOURNAL ARTICLE
Dmitri Mouradov, Paul Greenfield, Shan Li, Eun-Jung In, Claire Storey, Anuratha Sakthianandeswaren, Peter Georgeson, Daniel D Buchanan, Robyn L Ward, Nicholas J Hawkins, Iain Skinner, Ian T Jones, Peter Gibbs, Chenkai Ma, Yi Jin Liew, Kim Y C Fung, Oliver M Sieber
BACKGROUND & AIMS: Dysbiosis of gut microbiota is linked to the development of colorectal cancer (CRC). However, microbiota-based stratification of CRC tissue and how this relates to clinico-molecular characteristics and prognosis remains to be clarified. METHODS: Tumour and normal mucosa from 423 stage I-IV patients were profiled by bacterial 16S rRNA gene sequencing. Tumours were characterised for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), APC, BRAF, KRAS, PIK3CA, FBXW7, SMAD4 and TP53 mutations; subsets for chromosome instability (CIN), mutation signatures and consensus molecular subtypes (CMS)...
March 16, 2023: Gastroenterology
https://read.qxmd.com/read/36931573/molecular-profile-of-msh6-associated-colorectal-carcinomas-shows-distinct-features-from-other-lynch-syndrome-associated-colorectal-carcinomas
#17
JOURNAL ARTICLE
Noah C Helderman, Anne-Sophie van der Werf-'t Lam, Hans Morreau, Arnoud Boot, Tom van Wezel, Maartje Nielsen
No abstract text is available yet for this article.
March 15, 2023: Gastroenterology
https://read.qxmd.com/read/36921674/single-cell-profiling-of-tumor-immune-microenvironment-reveals-immune-irresponsiveness-in-gastric-signet-ring-cell-carcinoma
#18
JOURNAL ARTICLE
Jing Chen, Kuai Liu, Yikai Luo, Muxing Kang, Jun Wang, Guofeng Chen, Jia Qi, Wenxuan Wu, Beidi Wang, Yaxuan Han, Le Shi, Kefan Wang, Xiaying Han, Xiaojing Ma, Wei Liu, Yuan Ding, Liangjing Wang, Han Liang, Lie Wang, Jian Chen
BACKGROUND AND AIMS: Gastric cancer (GC) is a major cancer type characterized by high heterogeneity in both tumor cells and the tumor immune microenvironment (TIME). One intractable GC subtype is gastric signet-ring cell carcinoma (GSRCC), which is associated with poor prognosis. However, it remains unclear what the GSRCC TIME characteristics are and how these characteristics may contribute to clinical outcomes. METHODS: We enrolled 32 patients with advanced GC of diverse subtypes and profiled their TIME using an immune-targeted single-cell profiling strategy, including (i) immune-targeted single-cell RNA sequencing (scRNA-seq, n = 20 patients) and (ii) protein expression profiling by a targeted antibody panel for mass cytometry (CyTOF, n = 12 patients)...
March 13, 2023: Gastroenterology
https://read.qxmd.com/read/36907526/bmpr2-as-a-novel-predisposition-gene-for-hereditary-colorectal-polyposis
#19
JOURNAL ARTICLE
Laia Bonjoch, Ceres Fernandez-Rozadilla, Miriam Alvarez-Barona, Anael Lopez-Novo, Cristina Herrera-Pariente, Jorge Amigo, Luis Bujanda, David Remedios, Andrés Dacal, Joaquín Cubiella, Francesc Balaguer, Fernando Fernández-Bañares, Angel Carracedo, Rodrigo Jover, Sergi Castellvi-Bel, Clara Ruiz-Ponte
BACKGROUND AND AIMS: Colorectal cancer (CRC) is one of the most prevalent tumours worldwide, with incidences (particularly in the context of early-onset cases) quickly increasing despite important prevention efforts, mainly in the form of population-wide screening programmes. Although many cases present a clear familial component, the current list of hereditary CRC genes still leaves a considerable proportion of the cases unexplained. METHODS: In this work, we utilised whole-exome sequencing approaches on 19 unrelated patients with unexplained colonic polyposis to identify candidate CRC predisposition genes...
March 10, 2023: Gastroenterology
https://read.qxmd.com/read/36907525/a-two-in-one-hit-model-of-shortcut-carcinogenesis-in-mlh1-lynch-syndrome-carriers
#20
JOURNAL ARTICLE
Aysel Ahadova, Albrecht Stenzinger, Toni Seppälä, Robert Hüneburg, Matthias Kloor, Hendrik Bläker
No abstract text is available yet for this article.
March 10, 2023: Gastroenterology
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