journal
https://read.qxmd.com/read/33844987/human-microbiota-flagellins-drive-adaptive-immune-responses-in-crohn-s-disease
#1
Katie L Alexander, Qing Zhao, Meagan Reif, Alexander F Rosenberg, Peter J Mannon, Lennard Wayne Duck, Charles O Elson
BACKGROUND AND AIMS: Crohn's Disease (CD) and ulcerative colitis (UC) are characterized by dysregulated adaptive immune responses to the microbiota in genetically susceptible individuals, but the specificity of these responses remains largely undefined. Therefore, we developed a microbiota antigen microarray to characterize microbial antibody reactivity, particularly to human-derived microbiota flagellins, in inflammatory bowel disease. METHODS: Sera from healthy volunteers at the University of Alabama at Birmingham (UAB), n=87; patients recruited from the Kirklin Clinic of UAB Hospital, including patients with Crohn's disease, n=152; and Ulcerative colitis, n=170; was individually probed against microbiota bacterial flagellins of both mouse and human origin and analyzed for IgG and IgA antibody responses...
April 9, 2021: Gastroenterology
https://read.qxmd.com/read/33839101/comparative-effectiveness-of-multiple-different-first-line-treatment-regimens-for-helicobacter-pylori-infection-a-network-meta-analysis
#2
Theodore Rokkas, Javier P Gisbert, Peter Malfertheiner, Yaron Niv, Antonio Gasbarrini, Marcis Leja, Francis Megraud, Colm O'Morain, David Y Graham
BACKGROUND & AIMS: A number of double, triple and quadruple therapies have been proposed as first line H. pylori infection empiric treatments. However, knowledge of their worldwide and regional comparative efficacy is lacking. We examined the comparative effectiveness of all empirically used first line regimens tested against standard triple treatment, using a network meta-analysis (NWM) of published RCTs. METHODS: Data extracted from eligible RCTs were entered into a Bayesian NWM to investigate the comparative efficacy of H...
April 8, 2021: Gastroenterology
https://read.qxmd.com/read/33839100/gene-specific-variation-in-colorectal-cancer-surveillance-strategies-for-lynch-syndrome
#3
Fay Kastrinos, Myles A Ingram, Elisabeth R Silver, Aaron Oh, Monika Laszkowska, Anil K Rustgi, Chin Hur
BACKGROUND & AIMS: Lynch syndrome is associated with pathogenic variants in 4 mismatch repair (MMR) genes that increase lifetime risk of colorectal cancer (CRC). Guidelines recommend intensive CRC surveillance with colonoscopy every 1-2 years starting at 25 years for all carriers of Lynch syndrome-associated variants, regardless of gene product. We constructed a simulation model to analyze the effects of different ages of colonoscopy initiation and surveillance intervals for each MMR gene (MLH1, MSH2, MSH6, and PMS2) on CRC incidence and mortality, quality-adjusted life-years (QALYs), and cost...
April 8, 2021: Gastroenterology
https://read.qxmd.com/read/33839099/a-nerve-racking-cyst
#4
Francisco Baldaque-Silva, Carlos Fernández Moro, Urban Arnelo
No abstract text is available yet for this article.
April 8, 2021: Gastroenterology
https://read.qxmd.com/read/33839098/gastrointestinal-bleeding-and-acute-liver-failure
#5
A Gavotto, B Rivière, L Degravi
No abstract text is available yet for this article.
April 8, 2021: Gastroenterology
https://read.qxmd.com/read/33839097/a-case-of-recurrent-hepatic-abscesses
#6
Jessica L Sheehan, Justin Brandler, Michael D Rice
No abstract text is available yet for this article.
April 8, 2021: Gastroenterology
https://read.qxmd.com/read/33844988/fecal-microbiota-transplantation-for-recurrent-clostridioides-difficile-infection-associates-with-functional-alterations-in-circulating-micrornas
#7
Tanya M Monaghan, Anna M Seekatz, Nicholas O Markham, Tung On Yau, Maria Hatziapostolou, Tahseen Jilani, Niki Christodoulou, Brandi Roach, Eleni Birli, Odette Pomenya, Thomas Louie, D Borden Lacy, Peter Kim, Christine Lee, Dina Kao, Christos Polytarchou
BACKGROUND AND AIMS: The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alterations in microRNAs (miRs) following FMT for rCDI. METHODS: Sera from two prospective multicentre randomized controlled trials were analyzed for miRNA levels using the Nanostring nCounter platform and quantitative RT-PCR...
April 5, 2021: Gastroenterology
https://read.qxmd.com/read/33831381/no-association-between-endoscopic-screening-and-gastric-cancer-incidence-in-asian-countries
#8
LETTER
Xing Zhang, Honggang Zheng, Baojin Hua
No abstract text is available yet for this article.
April 5, 2021: Gastroenterology
https://read.qxmd.com/read/33831380/to-the-editors
#9
LETTER
Gil Melmed, David T Rubin, Dermot McGovern
No abstract text is available yet for this article.
April 5, 2021: Gastroenterology
https://read.qxmd.com/read/33831379/reply-to-letter-to-the-editor-effects-of-early-placement-of-transjugular-portosystemic-shunts-in-patients-with-high-risk-acute-variceal-bleeding-a-meta-analysis-of-individual-patient-data
#10
LETTER
Oana Nicoară-Farcău, Juan Carlos García-Pagán
No abstract text is available yet for this article.
April 5, 2021: Gastroenterology
https://read.qxmd.com/read/33819486/bmp-pathway-antagonism-by-grem1-regulates-epithelial-cell-fate-in-intestinal-regeneration
#11
Martijn Aj Koppens, Hayley Davis, Gabriel N Valbuena, Eoghan J Mulholland, Nadia Nasreddin, Mathilde Colombe, Agne Antanaviciute, Sujata Biswas, Matthias Friedrich, Lennard Lee, Lai Mun Wang, Viktor H Koelzer, James E East, Alison Simmons, Douglas J Winton, Simon J Leedham
BACKGROUND AND AIMS: In homeostasis, intestinal cell fate is controlled by balanced gradients of morphogen signalling. The Bone Morphogenetic Protein (BMP) pathway has a physiological, pro-differentiation role, predominantly inferred through previous experimental pathway inactivation. Intestinal regeneration is underpinned by dedifferentiation and cell plasticity, but the signalling pathways that regulate this adaptive reprogramming are not well understood. We assessed the BMP signalling landscape, and investigated the impact and therapeutic potential, of pathway manipulation in homeostasis and regeneration...
April 2, 2021: Gastroenterology
https://read.qxmd.com/read/33819485/epithelia-sensory-neuron-crosstalk-underlies-cholestatic-itch-induced-by-lysophosphatidylcholine
#12
Yong Chen, Zi-Long Wang, Michele Yeo, Qiao-Juan Zhang, Ana E López-Romero, Hui-Ping Ding, Xin Zhang, Qian Zeng, Sara L Morales-Lázaro, Carlene Moore, Ying-Ai Jin, Huang-He Yang, Johannes Morstein, Andrey Bortsov, Marcin Krawczyk, Frank Lammert, Manal Abdelmalek, Anna Mae Diehl, Piotr Milkiewicz, Andreas E Kremer, Jennifer Y Zhang, Andrea Nackley, Tony E Reeves, Mei-Chuan Ko, Ru-Rong Ji, Tamara Rosenbaum, Wolfgang Liedtke
BACKGROUND & AIMS: Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of anti-pruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. METHODS: Pruritogenicity of LPC, LPA's precursor, was examined in naïve mice, cholestatic mice, and nonhuman primates. LPC's pruritogenicity involving keratinocyte-TRPV4 was studied using genetic and pharmacological approaches, cultured keratinocytes, ion channel physiology and structural-computational modeling...
April 2, 2021: Gastroenterology
https://read.qxmd.com/read/33819484/a-liquid-biopsy-assay-for-noninvasive-identification-of-lymph-node-metastases-in-t1-colorectal-cancer
#13
Yuma Wada, Mitsuo Shimada, Tatsuro Murano, Hiroyuki Takamaru, Yuji Morine, Tetsuya Ikemoto, Yu Saito, Francesc Balaguer, Luis Bujanda, Maria Pellise, Ken Kato, Yutaka Saito, Hiroaki Ikematsu, Ajay Goel
BACKGROUND & AIMS: We recently reported use of tissue-based transcriptomic biomarkers (miRNA or mRNA) for identification of lymph node metastasis (LNM) in patients with invasive submucosal colorectal cancers (T1 CRC). In this study, we translated our tissue-based biomarkers into a blood-based liquid biopsy assay for noninvasive detection of LNM in patients with high-risk T1 CRC. METHODS: We analyzed 330 specimens from patients with high-risk T1 CRC, which included 188 serum samples from two clinical cohorts (training cohort: n=46, validation cohort: n=142) and matched FFPE samples (n=142)...
April 2, 2021: Gastroenterology
https://read.qxmd.com/read/33819483/intestinal-sulfation-is-essential-to-protect-against-colitis-and-colonic-carcinogenesis
#14
Pengfei Xu, Yue Xi, Junjie Zhu, Min Zhang, Zigmund Luka, Donna B Stolz, Xinran Cai, Yang Xie, Meishu Xu, Songrong Ren, Zhiying Huang, Da Yang, John D York, Xiaochao Ma, Wen Xie
BACKGROUND & AIMS: Sulfation is a conjugation reaction essential for numerous biochemical and cellular functions in mammals. The 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase 2 (PAPSS2) is the key enzyme to generate PAPS, which is the universal sulfonate donor for all sulfation reactions. The goal of this study is to determine whether and how PAPSS2 plays a role in colitis and colonic carcinogenesis. METHODS: Tissue arrays of human colon cancer specimens, gene expression data, and clinical features of cancer patients were analyzed...
April 2, 2021: Gastroenterology
https://read.qxmd.com/read/33819482/bcl3-couples-cancer-stem-cell-enrichment-with-pancreatic-cancer-molecular-subtypes
#15
Jiaoyu Ai, Sonja M Wörmann, Kıvanç Görgülü, Mireia Vallespinos, Sladjana Zagorac, Sonia Alcala, Nan Wu, Derya Kabacaoglu, Alexandra Berninger, Diego Navarro, Ezgi Kaya-Aksoy, Dietrich A Ruess, Katrin J Ciecielski, Marlena Kowalska, Ekin I Demir, Güralp O Ceyhan, Irina Heid, Rickmer Braren, Marc Riemann, Sabrina Schreiner, Samuel Hofmann, Maria Kutschke, Martin Jastroch, Julia Slotta-Huspenina, Alexander Muckenhuber, Anna Melissa Schlitter, Roland M Schmid, Katja Steiger, Kalliope N Diakopoulos, Marina Lesina, Bruno Sainz, Hana Algül
BACKGROUNG & AIMS: The existence of different subtypes of pancreatic ductal adenocarcinoma (PDAC) and their correlation with patient outcome have shifted the emphasis on patient classification for better decision-making algorithms and personalized therapy. The contribution of mechanisms regulating the cancer stem cell (CSC) population in different subtypes remains unknown. METHODS: Using RNA-seq, we identified B-cell CLL/lymphoma 3 (BCL3), an atypical NF-κB signaling member, as differing in pancreatic CSCs...
April 2, 2021: Gastroenterology
https://read.qxmd.com/read/33812896/pneumatosis-intestinalis-in-a-febrile-11-month-old-boy
#16
Kazuki Iio, Hiroshi Sakakibara
No abstract text is available yet for this article.
April 1, 2021: Gastroenterology
https://read.qxmd.com/read/33812895/revival-of-the-remnant-round-ligament-of-the-liver
#17
M Zorgdrager, R J de Haas, A L van den Boom
No abstract text is available yet for this article.
April 1, 2021: Gastroenterology
https://read.qxmd.com/read/33812894/erythematous-plaques-on-legs-and-feet-in-a-patient-with-hepatitis-c
#18
Chun Yu Cheng, Jennifer Wu
No abstract text is available yet for this article.
April 1, 2021: Gastroenterology
https://read.qxmd.com/read/33812893/a-mimicker-of-intraductal-papillary-mucinous-carcinoma-of-the-pancreas
#19
Akihiro Yoshida, Kentaro Yamao, Tomohiro Watanabe
No abstract text is available yet for this article.
April 1, 2021: Gastroenterology
https://read.qxmd.com/read/33812892/defer-no-time-delays-have-dangerous-ends-william-shakespeare
#20
Luc Biedermann, Alex Straumann, Petr Hruz
No abstract text is available yet for this article.
April 1, 2021: Gastroenterology
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