journal
https://read.qxmd.com/read/37718188/field-cancerization-is-associated-with-tumor-development-t-cell-exhaustion-and-clinical-outcomes-in-bladder-cancer
#1
JOURNAL ARTICLE
Trine Strandgaard, Iver Nordentoft, Karin Birkenkamp-Demtröder, Liina Salminen, Frederik Prip, Julie Rasmussen, Tine Ginnerup Andreasen, Sia Viborg Lindskrog, Emil Christensen, Philippe Lamy, Michael Knudsen, Torben Steiniche, Jørgen Bjerggaard Jensen, Lars Dyrskjøt
BACKGROUND: Field cancerization is characterized by areas of normal tissue affected by mutated clones. Bladder field cancerization may explain the development and recurrence of bladder cancer and may be associated with treatment outcomes. OBJECTIVE: To investigate the predictive and prognostic roles of field cancerization in patients with high-risk non-muscle-invasive bladder cancer (NMIBC) treated with bacillus Calmette-Guérin (BCG). DESIGN, SETTING, AND PARTICIPANTS: We conducted comprehensive genomic and proteomic analyses for 751 bladder biopsies and 234 urine samples from 136 patients with NMIBC...
September 15, 2023: European Urology
https://read.qxmd.com/read/37714742/avelumab-first-line-maintenance-for-advanced-urothelial-carcinoma-analysis-from-javelin-bladder-100-by-duration-of-first-line-chemotherapy-and-interval-before-maintenance
#2
JOURNAL ARTICLE
Srikala S Sridhar, Thomas Powles, Miguel Á Climent Durán, Se Hoon Park, Francesco Massari, Antoine Thiery-Vuillemin, Begoña P Valderrama, Anders Ullén, Norihiko Tsuchiya, Jeanny B Aragon-Ching, Shilpa Gupta, Daniel P Petrylak, Joaquim Bellmunt, Jing Wang, Robert J Laliberte, Alessandra di Pietro, Nuno Costa, Petros Grivas, Cora N Sternberg, Yohann Loriot
BACKGROUND: In the JAVELIN Bladder 100 phase 3 trial, avelumab first-line maintenance + best supportive care (BSC) prolonged overall survival (OS) and progression-free survival (PFS) versus BSC alone in patients with advanced urothelial carcinoma (advanced UC) without progression after first-line platinum-based chemotherapy. OBJECTIVE: To report post hoc analyses of subgroups defined by the duration of first-line chemotherapy and interval before maintenance...
September 13, 2023: European Urology
https://read.qxmd.com/read/37704541/early-detection-of-prostate-cancer-in-the-european-union-combining-forces-with-praise-u
#3
EDITORIAL
Hendrik Van Poppel, Monique J Roobol, Arunah Chandran
The European Association of Urology, together with consortium partners, has launched PRAISE-U (Prostate Cancer Awareness and Initiative for Screening in the European Union), a project involving 25 institutions across 12 countries that is funded under the EU4Health program. The aim is to reduce the morbidity and mortality of prostate cancer in EU member states via customized and risk-based screening programs.
September 11, 2023: European Urology
https://read.qxmd.com/read/37696741/re-stavros-gravas-mauro-gacci-christian-gratzke-et-al-summary-paper-on-the-2023-european-association-of-urology-guidelines-on-the-management-of-non-neurogenic-male-lower-urinary-tract-symptoms-eur-urol-2023-84-207-22
#4
LETTER
Francesco Montorsi, Paolo Capogrosso, Federico Dehò, Andrea Salonia
No abstract text is available yet for this article.
September 9, 2023: European Urology
https://read.qxmd.com/read/37696740/re-deep-learning-imaging-features-derived-from-kidney-ultrasounds-predict-chronic-kidney-disease-progression-in-children-with-posterior-urethral-valves
#5
JOURNAL ARTICLE
Lisette A 't Hoen
No abstract text is available yet for this article.
September 9, 2023: European Urology
https://read.qxmd.com/read/37696739/re-mingxiao-feng-andres-matoso-gabriel-epstein-et-al-identification-of-lineage-specific-transcriptional-factor-defined-molecular-subtypes-in-small-cell-bladder-cancer-eur-urol-in-press-https-doi-org-10-1016-j-eururo-2023-05-023
#6
LETTER
https://read.qxmd.com/read/37696738/re-holmium-laser-enucleation-of-the-prostate-is-associated-with-complications-and-sequelae-even-in-the-hands-of-an-experienced-surgeon-following-completion-of-the-learning-curve
#7
JOURNAL ARTICLE
https://read.qxmd.com/read/37696737/re-genetically-adjusted-psa-levels-for-prostate-cancer-screening
#8
JOURNAL ARTICLE
Martin C Michel
No abstract text is available yet for this article.
September 9, 2023: European Urology
https://read.qxmd.com/read/37696736/re-platelet-rich-plasma-for-the-treatment-of-erectile-dysfunction-a-prospective-randomized-double-blind-placebo-controlled-clinical-trial
#9
JOURNAL ARTICLE
Mikkel Fode, Christian Fuglesang S Jensen, Jens Sønksen
No abstract text is available yet for this article.
September 9, 2023: European Urology
https://read.qxmd.com/read/37689512/re-david-dan-nguyen-liam-murad-anne-xuan-lan-nguyen-et-al-industry-payments-to-american-editorial-board-members-of-major-urology-journals-eur-urol-in-press-https-doi-org-10-1016-j-eururo-2023-04-017
#10
LETTER
https://read.qxmd.com/read/37689511/reply-to-laura-e-davis-adam-calaway-and-laura-bukavina-s-letter-to-the-editor-re-nima-nassiri-giovanni-cacciamani-inderbir-s-gill-robotic-bladder-auto-transplantation-in-a-heart-beating-brain-dead-human-research-donor-eur-urol-in-press-https-doi-org-10-1016
#11
LETTER
https://read.qxmd.com/read/37684178/nephron-sparing-treatment-nest-for-small-renal-masses-a-feasibility-cohort-embedded-randomised-controlled-trial-comparing-percutaneous-cryoablation-and-robot-assisted-partial-nephrectomy
#12
JOURNAL ARTICLE
Joana B Neves, Hannah Warren, Joseph Santiapillai, Nicola Rode, David Cullen, Menelaos Pavlou, Miles Walkden, Prasad Patki, Ravi Barod, Faiz Mumtaz, Michael Aitchison, Steven Bandula, Elena Pizzo, Veronica Ranieri, Norman Williams, William Wildgoose, Kurinchi Gurusamy, Mark Emberton, Axel Bex, Maxine G B Tran
There is a paucity of high-level evidence on small renal mass (SRM) management, as previous classical randomised controlled trials (RCTs) failed to meet accrual targets. Our objective was to assess the feasibility of recruitment to a cohort-embedded RCT comparing cryoablation (CRA) to robotic partial nephrectomy (RPN). A total of 200 participants were recruited to the cohort, of whom 50 were enrolled in the RCT. In the RCA intervention arm, 84% consented (95% confidence interval [CI] 64-95%) and 76% (95% CI 55-91%) received CRA; 100% (95% CI 86-100%) of the control arm underwent RPN...
September 6, 2023: European Urology
https://read.qxmd.com/read/37684177/re-freddie-c-hamdy-jenny-l-donovan-j-athene-lane-et-al-fifteen-year-outcomes-after-monitoring-surgery-or-radiotherapy-for-prostate-cancer-n-engl-j-med-2023-388-1547-58
#13
LETTER
Bernardo Rocco, Maria Chiara Sighinolfi
No abstract text is available yet for this article.
September 6, 2023: European Urology
https://read.qxmd.com/read/37679268/re-nima-nassiri-giovanni-cacciamani-inderbir-s-gill-robotic-bladder-auto-transplantation-in-a-heart-beating-brain-dead-human-research-donor-eur-urol-in-press-https-doi-org-10-1016-j-eururo-2023-06-004
#14
LETTER
https://read.qxmd.com/read/37673752/the-role-of-99m-tc-sestamibi-single-photon-emission-computed-tomography-computed-tomography-in-the-diagnostic-pathway-for-renal-masses-a-systematic-review-and-meta-analysis
#15
REVIEW
Giuseppe Basile, Giuseppe Fallara, Paolo Verri, Alessandro Uleri, Arturo Chiti, Luigi Gianolli, Gino Pepe, Alessandro Tedde, Ferran Algaba, Angelo Territo, Francesco Sanguedolce, Alessandro Larcher, Andrea Gallioli, Joan Palou, Francesco Montorsi, Umberto Capitanio, Alberto Breda
CONTEXT: The diagnostic accuracy of current imaging techniques in differentiating benign from malignant neoplasms in the case of indeterminate renal masses is still suboptimal. OBJECTIVE: To evaluate the diagnostic accuracy of 99m Tc-sestamibi (SestaMIBI) single-photon emission tomography computed tomography (SPECT)/CT in characterizing indeterminate renal masses by differentiating renal oncocytoma and hybrid oncocytic/chromophobe tumor (HOCT) from (1) all other renal lesions and (2) all malignant renal lesions...
September 4, 2023: European Urology
https://read.qxmd.com/read/37673751/metaverse-surgical-planning-with-three-dimensional-virtual-models-for-minimally-invasive-partial-nephrectomy
#16
Enrico Checcucci, Daniele Amparore, Gabriele Volpi, Sabrina De Cillis, Federico Piramide, Paolo Verri, Alberto Piana, Michele Sica, Cecilia Gatti, Paolo Alessio, Alberto Quarà, Mariano Burgio, Marco Colombo, Giovanni Busacca, Alex Mottrie, Edward Cherullo, Alberto Breda, Alessandro Antonelli, Renaud Bollens, Andrea Minervini, James Porter, Riccardo Schiavina, Riccardo Autorino, Ashutosh Tewari, Michele Di Dio, Cristian Fiori, Francesco Porpiglia
The recent integration of new virtual visualization modalities with artificial intelligence and high-speed internet connection has opened the door to the advent of the metaverse in medicine. In this totally virtual environment, three-dimensional virtual models (3DVMs) of the patient's anatomy can be visualized and discussed via digital avatars. Here we present for the first time a metaverse preoperative clinical case discussion before minimally invasive partial nephrectomy. The surgeons' digital avatars met in a virtual room and participated in a virtual consultation on the surgical strategy and clamping approach before the procedure...
September 4, 2023: European Urology
https://read.qxmd.com/read/37666734/corrigendum-to-pembrolizumab-plus-axitinib-versus-sunitinib-as-first-line-treatment-of-advanced-renal-cell-carcinoma-43-month-follow-up-of-the-phase-3-keynote-426-study-eur-urol-2023
#17
Elizabeth R Plimack, Thomas Powles, Viktor Stus, Rustem Gafanov, Dmitry Nosov, Tom Waddell, Boris Alekseev, Frédéric Pouliot, Bohuslav Melichar, Denis Soulières, Delphine Borchiellini, Raymond S McDermott, Ihor Vynnychenko, Yen-Hwa Chang, Satoshi Tamada, Michael B Atkins, Chenxiang Li, Rodolfo Perini, L Rhoda Molife, Jens Bedke, Brian I Rini
No abstract text is available yet for this article.
September 2, 2023: European Urology
https://read.qxmd.com/read/37661553/re-matthew-s-ernst-vishal-navani-j-connor-wells-et-al-outcomes-for-international-metastatic-renal-cell-carcinoma-database-consortium-prognostic-groups-in-contemporary-first-line-combination-therapies-for-metastatic-renal-cell-carcinoma-eur-urol-2023-84-109
#18
LETTER
https://read.qxmd.com/read/37661552/reply-to-thomas-seisen-morgan-roupr%C3%A3%C2%AAt-and-pierre-blanchard-s-letter-to-the-editor-re-alexandre-r-zlotta-leslie-k-ballas-andrzej-niemierko-et-al-radical-cystectomy-versus-trimodality-therapy-for-muscle-invasive-bladder-cancer-a-multi-institutional-propensity
#19
LETTER
https://read.qxmd.com/read/37659962/metformin-overcomes-the-consequences-of-nkx3-1-loss-to-suppress-prostate-cancer-progression
#20
JOURNAL ARTICLE
Alexandros Papachristodoulou, Isabel Heidegger, Renu K Virk, Matteo Di Bernardo, Jaime Y Kim, Caroline Laplaca, Florencia Picech, Georg Schäfer, Guarionex Joel De Castro, Hanina Hibshoosh, Massimo Loda, Helmut Klocker, Mark A Rubin, Tian Zheng, Mitchell C Benson, James M McKiernan, Aditya Dutta, Cory Abate-Shen
BACKGROUND: The antidiabetic drug metformin has known anticancer effects related to its antioxidant activity; however, its clinical benefit for prostate cancer (PCa) has thus far been inconclusive. Here, we investigate whether the efficacy of metformin in PCa is related to the expression status of NKX3.1, a prostate-specific homeobox gene that functions in mitochondria to protect the prostate from aberrant oxidative stress. OBJECTIVE: To investigate the relationship of NKX3...
August 31, 2023: European Urology
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