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European Urology

Valeria Panebianco, Yoshi Narumi, Giovanni Barchetti, Rodolfo Montironi, James W F Catto
No abstract text is available yet for this article.
April 15, 2019: European Urology
Kiri A Sandler, Ryan R Cook, Jay P Ciezki, Ashley E Ross, Mark M Pomerantz, Paul L Nguyen, Talha Shaikh, Phuoc T Tran, Richard G Stock, Gregory S Merrick, David Jeffrey Demanes, Daniel E Spratt, Eyad I Abu-Isa, Trude B Wedde, Wolfgang Lilleby, Daniel J Krauss, Grace K Shaw, Ridwan Alam, Chandana A Reddy, Daniel Y Song, Eric A Klein, Andrew J Stephenson, Jeffrey J Tosoian, John V Hegde, Sun Mi Yoo, Ryan Fiano, Anthony V D'Amico, Nicholas G Nickols, William J Aronson, Ahmad Sadeghi, Stephen C Greco, Curtiland Deville, Todd McNutt, Theodore L DeWeese, Robert E Reiter, Jonathan W Said, Michael L Steinberg, Eric M Horwitz, Patrick A Kupelian, Christopher R King, Amar U Kishan
BACKGROUND: The role of elective whole-pelvis radiotherapy (WPRT) remains controversial. Few studies have investigated it in Gleason grade group (GG) 5 prostate cancer (PCa), known to have a high risk of nodal metastases. OBJECTIVE: To assess the impact of WPRT on patients with GG 5 PCa treated with external-beam radiotherapy (EBRT) or EBRT with a brachytherapy boost (EBRT+BT). DESIGN, SETTING, AND PARTICIPANTS: We identified 1170 patients with biopsy-proven GG 5 PCa from 11 centers in the United States and one in Norway treated between 2000 and 2013 (734 with EBRT and 436 with EBRT+BT)...
April 13, 2019: European Urology
Marco Moschini, Idir Ouzaid, Evanguelos Xylinas
No abstract text is available yet for this article.
April 12, 2019: European Urology
Andrea Minervini, Andrea Mari, Riccardo Campi, Marco Carini
No abstract text is available yet for this article.
April 12, 2019: European Urology
Thomas Horn, Markus Krönke, Isabel Rauscher, Bernhard Haller, Stephanie Robu, Hans-Jürgen Wester, Margret Schottelius, Fijs W B van Leeuwen, Henk G van der Poel, Matthias Heck, Jürgen E Gschwend, Wolfgang Weber, Matthias Eiber, Tobias Maurer
BACKGROUND: Prostate-specific membrane antigen (PSMA)-ligand positron emission tomography (PET) allows detection of metastatic prostate cancer (PC) lesions at low prostate-specific antigen (PSA) values. To facilitate their intraoperative detection during salvage surgery, we recently introduced PSMA-targeted radioguided surgery (RGS). OBJECTIVE: To describe the outcome of a large cohort of patients treated with PSMA-targeted RGS and to establish prognostic factors...
April 12, 2019: European Urology
Francesco Soria, Paolo Gontero
No abstract text is available yet for this article.
April 12, 2019: European Urology
Alberto Saita, Giovanni Lughezzani, Nicolò Maria Buffi, Rodolfo Hurle, Luciano Nava, Piergiuseppe Colombo, Pietro Diana, Vittorio Fasulo, Marco Paciotti, Grazia Maria Elefante, Massimo Lazzeri, Giorgio Guazzoni, Paolo Casale
BACKGROUND: Magnetic resonance imaging (MRI) has been proposed as a staging tool for bladder cancer (BC), but its use has been limited by its high costs and limited availability. Microultrasound (mUS) is a novel technology capable of providing high-resolution images of the prostate. OBJECTIVE: To test the feasibility of high-resolution mUS in patients diagnosed with BC and its ability to differentiate between non-muscle-invasive BC (NMIBC) and muscle-invasive BC (MIBC)...
April 10, 2019: European Urology
Francesco Porpiglia, Enrico Checcucci, Daniele Amparore, Matteo Manfredi, Federica Massa, Pietro Piazzolla, Diego Manfrin, Alberto Piana, Daniele Tota, Enrico Bollito, Cristian Fiori
BACKGROUND: In prostate cancer (PCa) surgical procedures, in order to maximize potency recovery, a nerve-sparing (NS) procedure is preferred. However, cancer abutting or focally extending beyond the prostate capsule increases the risk of a positive surgical margin. OBJECTIVE: To evaluate the accuracy of our new three-dimensional (3D) elastic augmented-reality (AR) system in identifying capsular involvement (CI) location of PCa during the NS phase of robot-assisted radical prostatectomy (RARP)...
April 9, 2019: European Urology
Alessandro Larcher, Geert De Naeyer, Filippo Turri, Paolo Dell'Oglio, Umberto Capitanio, Justin W Collins, Peter Wiklund, Henk Van Der Poel, Francesco Montorsi, Alexandre Mottrie
BACKGROUND: No validated training program for robot-assisted partial nephrectomy (RAPN) exists. OBJECTIVE: To define the structure and provide a pilot clinical validation of a curriculum for robot-assisted partial nephrectomy (RAPN). DESIGN, SETTING, AND PARTICIPANTS: A modified Delphi consensus methodology involving 27 experts defined curriculum structure. One trainee completed the curriculum under the mentorship of an expert. A total of 40 patients treated with curriculum RAPN (cRAPN) were compared with 160 patients treated with standard of care (sRAPN)...
April 9, 2019: European Urology
Ming-Jun Shi, Xiang-Yu Meng, Philippe Lamy, A Rouf Banday, Jie Yang, Aura Moreno-Vega, Chun-Long Chen, Lars Dyrskjøt, Isabelle Bernard-Pierrot, Ludmila Prokunina-Olsson, François Radvanyi
FGFR3 is one of the most frequently mutated genes in bladder cancer and a driver of an oncogenic dependency. Here we report that only the most common recurrent FGFR3 mutation, S249C (TCC→TGC), represents an APOBEC-type motif and is probably caused by the APOBEC-mediated mutagenic process, accounting for its over-representation. We observed significant enrichment of the APOBEC mutational signature and overexpression of AID/APOBEC gene family members in bladder tumors with S249C compared to tumors with other recurrent FGFR3 mutations...
April 8, 2019: European Urology
Gunnar Steineck, Olof Akre, Anna Bill-Axelson
No abstract text is available yet for this article.
April 8, 2019: European Urology
Ryan P Werntz, Scott E Eggener
No abstract text is available yet for this article.
April 5, 2019: European Urology
Derya Tilki, Felix Preisser, Markus Graefen, Hartwig Huland, Raisa S Pompe
The impact of biochemical recurrence (BCR) after radical treatment of prostate cancer on oncological outcomes remains unclear. A new European Association of Urology BCR risk stratification (low and high risk) has been proposed. To validate these risk groups, we retrospectively analyzed data for 1125 post-radical prostatectomy (RP) BCR patients (surgery between 1992 and 2006). Univariable Kaplan-Meier plots and multivariable Cox regression models with time-dependent covariates were used to test the independent predictor status of the risk grouping on metastatic progression (MP) and prostate cancer-specific mortality (PCSM)...
April 5, 2019: European Urology
Jeanette C Reece, David C Dangerfield, Christopher J Coombs
BACKGROUND: Radical prostatectomy (RP) is recommended for the treatment of men with clinically localised prostate cancer. However, RP is associated with a high incidence of erectile dysfunction (ED), which can impact the quality of life (QoL) significantly. OBJECTIVE: To evaluate the effectiveness of end-to-side nerve grafting surgery to restore erectile function and improve sexual QoL in men with ED after RP. DESIGN, SETTING, AND PARTICIPANTS: A retrospective review of a single-centre experience of nerve grafting in men with ED following RP was performed...
April 4, 2019: European Urology
Xavier Cathelineau, Petr Macek, Rafael Sanchez-Salas
No abstract text is available yet for this article.
April 4, 2019: European Urology
Joaquin Mateo, Suzanne Carreira, Johann S de Bono
No abstract text is available yet for this article.
April 3, 2019: European Urology
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