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European Urology

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https://read.qxmd.com/read/31000355/should-we-perform-multiparametric-magnetic-resonance-imaging-of-the-bladder-before-transurethral-resection-of-bladder-time-to-reconsider-the-rules
#1
EDITORIAL
Valeria Panebianco, Yoshi Narumi, Giovanni Barchetti, Rodolfo Montironi, James W F Catto
No abstract text is available yet for this article.
April 15, 2019: European Urology
https://read.qxmd.com/read/30992160/prostate-only-versus-whole-pelvis-radiation-with-or-without-a-brachytherapy-boost-for-gleason-grade-group-5-prostate-cancer-a-retrospective-analysis
#2
Kiri A Sandler, Ryan R Cook, Jay P Ciezki, Ashley E Ross, Mark M Pomerantz, Paul L Nguyen, Talha Shaikh, Phuoc T Tran, Richard G Stock, Gregory S Merrick, David Jeffrey Demanes, Daniel E Spratt, Eyad I Abu-Isa, Trude B Wedde, Wolfgang Lilleby, Daniel J Krauss, Grace K Shaw, Ridwan Alam, Chandana A Reddy, Daniel Y Song, Eric A Klein, Andrew J Stephenson, Jeffrey J Tosoian, John V Hegde, Sun Mi Yoo, Ryan Fiano, Anthony V D'Amico, Nicholas G Nickols, William J Aronson, Ahmad Sadeghi, Stephen C Greco, Curtiland Deville, Todd McNutt, Theodore L DeWeese, Robert E Reiter, Jonathan W Said, Michael L Steinberg, Eric M Horwitz, Patrick A Kupelian, Christopher R King, Amar U Kishan
BACKGROUND: The role of elective whole-pelvis radiotherapy (WPRT) remains controversial. Few studies have investigated it in Gleason grade group (GG) 5 prostate cancer (PCa), known to have a high risk of nodal metastases. OBJECTIVE: To assess the impact of WPRT on patients with GG 5 PCa treated with external-beam radiotherapy (EBRT) or EBRT with a brachytherapy boost (EBRT+BT). DESIGN, SETTING, AND PARTICIPANTS: We identified 1170 patients with biopsy-proven GG 5 PCa from 11 centers in the United States and one in Norway treated between 2000 and 2013 (734 with EBRT and 436 with EBRT+BT)...
April 13, 2019: European Urology
https://read.qxmd.com/read/30987846/re-impact-of-adjuvant-chemotherapy-in-patients-with-adverse-features-and-variant-histology-at-radical-cystectomy-for-muscle-invasive-carcinoma-of-the-bladder-does-histologic-subtype-matter
#3
Marco Moschini, Idir Ouzaid, Evanguelos Xylinas
No abstract text is available yet for this article.
April 12, 2019: European Urology
https://read.qxmd.com/read/30987845/re-health-economic-analysis-of-open-and-robot-assisted-laparoscopic-surgery-for-prostate-cancer-within-the-prospective-multicentre-lappro-trial
#4
Andrea Minervini, Andrea Mari, Riccardo Campi, Marco Carini
No abstract text is available yet for this article.
April 12, 2019: European Urology
https://read.qxmd.com/read/30987844/re-effect-of-adding-docetaxel-to-androgen-deprivation-therapy-in-patients-with-high-risk-prostate-cancer-with-rising-prostate-specific-antigen-levels-after-primary-local-therapy-a-randomized-clinical-trial
#5
https://read.qxmd.com/read/30987843/single-lesion-on-prostate-specific-membrane-antigen-ligand-positron-emission-tomography-and-low-prostate-specific-antigen-are-prognostic-factors-for-a-favorable-biochemical-response-to-prostate-specific-membrane-antigen-targeted-radioguided-surgery-in-recurrent
#6
Thomas Horn, Markus Krönke, Isabel Rauscher, Bernhard Haller, Stephanie Robu, Hans-Jürgen Wester, Margret Schottelius, Fijs W B van Leeuwen, Henk G van der Poel, Matthias Heck, Jürgen E Gschwend, Wolfgang Weber, Matthias Eiber, Tobias Maurer
BACKGROUND: Prostate-specific membrane antigen (PSMA)-ligand positron emission tomography (PET) allows detection of metastatic prostate cancer (PC) lesions at low prostate-specific antigen (PSA) values. To facilitate their intraoperative detection during salvage surgery, we recently introduced PSMA-targeted radioguided surgery (RGS). OBJECTIVE: To describe the outcome of a large cohort of patients treated with PSMA-targeted RGS and to establish prognostic factors...
April 12, 2019: European Urology
https://read.qxmd.com/read/30987842/re-extended-versus-limited-lymph-node-dissection-in-bladder-cancer-patients-undergoing-radical-cystectomy-survival-results-from-a-prospective-randomized-trial
#7
Francesco Soria, Paolo Gontero
No abstract text is available yet for this article.
April 12, 2019: European Urology
https://read.qxmd.com/read/30981590/assessing-the-feasibility-and-accuracy-of-high-resolution-microultrasound-imaging-for-bladder-cancer-detection-and-staging
#8
Alberto Saita, Giovanni Lughezzani, Nicolò Maria Buffi, Rodolfo Hurle, Luciano Nava, Piergiuseppe Colombo, Pietro Diana, Vittorio Fasulo, Marco Paciotti, Grazia Maria Elefante, Massimo Lazzeri, Giorgio Guazzoni, Paolo Casale
BACKGROUND: Magnetic resonance imaging (MRI) has been proposed as a staging tool for bladder cancer (BC), but its use has been limited by its high costs and limited availability. Microultrasound (mUS) is a novel technology capable of providing high-resolution images of the prostate. OBJECTIVE: To test the feasibility of high-resolution mUS in patients diagnosed with BC and its ability to differentiate between non-muscle-invasive BC (NMIBC) and muscle-invasive BC (MIBC)...
April 10, 2019: European Urology
https://read.qxmd.com/read/30979637/will-favourable-functional-results-with-salvage-robot-assisted-laparoscopic-radical-prostatectomy-increase-the-uptake-of-primary-focal-therapy-for-localised-prostate-cancer
#9
EDITORIAL
https://read.qxmd.com/read/30979636/three-dimensional-elastic-augmented-reality-robot-assisted-radical-prostatectomy-using-hyperaccuracy-three-dimensional-reconstruction-technology-a-step-further-in-the-identification-of-capsular-involvement
#10
Francesco Porpiglia, Enrico Checcucci, Daniele Amparore, Matteo Manfredi, Federica Massa, Pietro Piazzolla, Diego Manfrin, Alberto Piana, Daniele Tota, Enrico Bollito, Cristian Fiori
BACKGROUND: In prostate cancer (PCa) surgical procedures, in order to maximize potency recovery, a nerve-sparing (NS) procedure is preferred. However, cancer abutting or focally extending beyond the prostate capsule increases the risk of a positive surgical margin. OBJECTIVE: To evaluate the accuracy of our new three-dimensional (3D) elastic augmented-reality (AR) system in identifying capsular involvement (CI) location of PCa during the NS phase of robot-assisted radical prostatectomy (RARP)...
April 9, 2019: European Urology
https://read.qxmd.com/read/30979635/the-erus-curriculum-for-robot-assisted-partial-nephrectomy-structure-definition-and-pilot-clinical-validation
#11
Alessandro Larcher, Geert De Naeyer, Filippo Turri, Paolo Dell'Oglio, Umberto Capitanio, Justin W Collins, Peter Wiklund, Henk Van Der Poel, Francesco Montorsi, Alexandre Mottrie
BACKGROUND: No validated training program for robot-assisted partial nephrectomy (RAPN) exists. OBJECTIVE: To define the structure and provide a pilot clinical validation of a curriculum for robot-assisted partial nephrectomy (RAPN). DESIGN, SETTING, AND PARTICIPANTS: A modified Delphi consensus methodology involving 27 experts defined curriculum structure. One trainee completed the curriculum under the mentorship of an expert. A total of 40 patients treated with curriculum RAPN (cRAPN) were compared with 160 patients treated with standard of care (sRAPN)...
April 9, 2019: European Urology
https://read.qxmd.com/read/30975452/apobec-mediated-mutagenesis-as-a-likely-cause-of-fgfr3-s249c-mutation-over-representation-in-bladder-cancer
#12
Ming-Jun Shi, Xiang-Yu Meng, Philippe Lamy, A Rouf Banday, Jie Yang, Aura Moreno-Vega, Chun-Long Chen, Lars Dyrskjøt, Isabelle Bernard-Pierrot, Ludmila Prokunina-Olsson, François Radvanyi
FGFR3 is one of the most frequently mutated genes in bladder cancer and a driver of an oncogenic dependency. Here we report that only the most common recurrent FGFR3 mutation, S249C (TCC→TGC), represents an APOBEC-type motif and is probably caused by the APOBEC-mediated mutagenic process, accounting for its over-representation. We observed significant enrichment of the APOBEC mutational signature and overexpression of AID/APOBEC gene family members in bladder tumors with S249C compared to tumors with other recurrent FGFR3 mutations...
April 8, 2019: European Urology
https://read.qxmd.com/read/30975451/solid-science-for-the-upside-but-lack-of-solid-science-for-the-downside-towards-cutting-edge-prostate-cancer-screening
#13
EDITORIAL
Gunnar Steineck, Olof Akre, Anna Bill-Axelson
No abstract text is available yet for this article.
April 8, 2019: European Urology
https://read.qxmd.com/read/30967298/reply-to-xueliang-zhou-and-xinwei-han-s-letter-to-the-editor-re-thomas-van-den-broeck-roderick-c-n-van-den-bergh-nicolas-arfi-et-al-prognostic-value-of-biochemical-recurrence-following-treatment-with-curative-intent-for-prostate-cancer-a-systematic-review-eur
#14
LETTER
https://read.qxmd.com/read/30962042/re-use-of-active-surveillance-or-watchful-waiting-for-low-risk-prostate-cancer-and-management-trends-across-risk-groups-in-the-united-states-2010-2015
#15
Ryan P Werntz, Scott E Eggener
No abstract text is available yet for this article.
April 5, 2019: European Urology
https://read.qxmd.com/read/30955970/external-validation-of-the-european-association-of-urology-biochemical-recurrence-risk-groups-to-predict-metastasis-and-mortality-after-radical-prostatectomy-in-a-european-cohort
#16
Derya Tilki, Felix Preisser, Markus Graefen, Hartwig Huland, Raisa S Pompe
The impact of biochemical recurrence (BCR) after radical treatment of prostate cancer on oncological outcomes remains unclear. A new European Association of Urology BCR risk stratification (low and high risk) has been proposed. To validate these risk groups, we retrospectively analyzed data for 1125 post-radical prostatectomy (RP) BCR patients (surgery between 1992 and 2006). Univariable Kaplan-Meier plots and multivariable Cox regression models with time-dependent covariates were used to test the independent predictor status of the risk grouping on metastatic progression (MP) and prostate cancer-specific mortality (PCSM)...
April 5, 2019: European Urology
https://read.qxmd.com/read/30955973/end-to-side-somatic-to-autonomic-nerve-grafting-to-restore-erectile-function-and-improve-quality-of-life-after-radical-prostatectomy
#17
Jeanette C Reece, David C Dangerfield, Christopher J Coombs
BACKGROUND: Radical prostatectomy (RP) is recommended for the treatment of men with clinically localised prostate cancer. However, RP is associated with a high incidence of erectile dysfunction (ED), which can impact the quality of life (QoL) significantly. OBJECTIVE: To evaluate the effectiveness of end-to-side nerve grafting surgery to restore erectile function and improve sexual QoL in men with ED after RP. DESIGN, SETTING, AND PARTICIPANTS: A retrospective review of a single-centre experience of nerve grafting in men with ED following RP was performed...
April 4, 2019: European Urology
https://read.qxmd.com/read/30955972/re-radical-prostatectomy-or-watchful-waiting-in-prostate-cancer-29-year-follow-up
#18
Xavier Cathelineau, Petr Macek, Rafael Sanchez-Salas
No abstract text is available yet for this article.
April 4, 2019: European Urology
https://read.qxmd.com/read/30955971/re-68-ga-labeled-prostate-specific-membrane-antigen-ligand-positron-emission-tomography-computed-tomography-for-prostate-cancer-a-systematic-review-and-meta-analysis
#19
https://read.qxmd.com/read/30954315/parp-inhibitors-for-advanced-prostate-cancer-validating-predictive-biomarkers
#20
EDITORIAL
Joaquin Mateo, Suzanne Carreira, Johann S de Bono
No abstract text is available yet for this article.
April 3, 2019: European Urology
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