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European Journal of Pain: EJP

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https://read.qxmd.com/read/30746810/strength-and-range-of-movement-deficits-are-associated-with-symptom-severity-in-people-scheduled-for-hip-arthroscopy
#1
Matthew Freke, Joanne Kemp, Kay Crossley, Kevin Sims, Trevor Russell, Adam Semciw
BACKGROUND: Identifying the physical impairments associated with worse symptoms and greater functional limitations in people with hip pain could enable targeted rehabilitation programmes designed to improve quality of life. The objective of this study was to compare physical characteristics between subgroups of symptoms and functional limitation severity in individuals with hip pain scheduled for arthroscopic surgery. METHODS: Hip range of motion (ROM) and muscle strength were measured in 114 individuals (48 women; aged 32 ± 8 years) with hip pain scheduled for hip arthroscopy...
February 12, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30735280/the-importance-of-being-specific
#2
Jose Antonio Lopez Garcia
In this issue, you will find a paper by Vasović et al., entitled "Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6GABAA receptors" (D. Vasović et al., 2019). Loss of GABA-mediated inhibition within pain circuits is one of the mechanisms commonly invoked to explain allodynia and hyperalgesia following injury. Intrathecal administration of picrotoxin produces pain like signs. Positive allosteric modulators of GABAA receptors like benzodiazepines are known to produce analgesia although their main effects are sedative, hypnotic and anxiolytic and therefore their use as analgesics is curtailed (Schliessbach et al...
February 8, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30735277/sex-matters-in-complex-regional-pain-syndrome
#3
Gijsbrecht A J van Velzen, Frank J P M Huygen, Maarten van Kleef, Frank V van Eijs, Johan Marinus, Jacobus J van Hilten
BACKGROUND: Complex Regional Pain Syndrome (CRPS) is much more prevalent in women than men but potential differences in clinical phenotype have not been thoroughly explored to date. Differences in the clinical presentation between sexes may point at new avenues for a more tailored management approach of CRPS. We therefore explored if in CRPS the patient's sex is associated with differences in clinical and psychological characteristics. METHODS: In this cross-sectional study of 698 CRPS patients (599 females) fulfilling the Budapest clinical or research criteria, CRPS signs and symptoms, CRPS severity, pain (average pain intensity in the previous week and McGill pain rating index), pain coping (Pain Coping Inventory), physical limitations (Radboud Skills Questionnaire (upper limb), Walking and Rising questionnaire (lower limb)), anxiety and depression (Hospital Anxiety and Depression scale) and kinesiophobia (Tampa scale for kinesiophobia) were evaluated...
February 8, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30719817/ketamine-infusion-for-96-hr-after-thoracotomy-effects-on-acute-and-persistent-pain
#4
Gillian M Chumbley, Lindsey Thompson, Joanna E Swatman, Catherine Urch
INTRODUCTION: Pain which persists after thoracotomy is well recognized, and activation of the N-methyl-d-aspartate (NMDA) receptor could be a contributing factor. This study sought to establish whether ketamine given peri-operatively could reduce persistent post-surgical pain. TRIAL DESIGN: Double-blind, randomized, placebo-controlled trial comparing low-dose intravenous ketamine and saline placebo. METHODS: Seventy patients undergoing thoracotomy were randomized to receive either intravenous ketamine (0...
February 4, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30707486/non-pharmacological-management-of-persistent-headaches-associated-with-neck-pain-a-clinical-practice-guideline-from-the-ontario-protocol-for-traffic-injury-management-optima-collaboration
#5
REVIEW
Pierre Côté, Hainan Yu, Heather M Shearer, Kristi Randhawa, Jessica J Wong, Silvano Mior, Arthur Ameis, Linda J Carroll, Margareta Nordin, Sharanya Varatharajan, Deborah Sutton, Danielle Southerst, Craig Jacobs, Maja Stupar, Anne Taylor-Vaisey, Douglas P Gross, Robert J Brison, Mike Paulden, Carlo Ammendolia, J David Cassidy, Patrick Loisel, Shawn Marshall, Richard N Bohay, John Stapleton, Michel Lacerte
OBJECTIVES: To develop an evidence-based guideline for the non-pharmacological management of persistent headaches associated with neck pain (i.e., tension-type or cervicogenic). METHODS: This guideline is based on systematic reviews of high-quality studies. A multidisciplinary expert panel considered the evidence of clinical benefits, cost-effectiveness, societal and ethical values, and patient experiences when formulating recommendations. Target audience includes clinicians; target population is adults with persistent headaches associated with neck pain...
February 1, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30707478/contralateral-segmental-transcutaneous-electrical-nerve-stimulation-inhibits-nociceptive-flexion-reflex-in-healthy-participants
#6
Nobuhiro Takiguchi, Koji Shomoto
BACKGROUND: Transcutaneous electrical nerve stimulation (TENS) is a non-invasive treatment to relieve pain. Contralateral TENS (i.e., TENS administered to the contralateral side of a painful body part) is beneficial when TENS cannot be directly applied to pain site, such as in cases of trauma. Although TENS produces segmental analgesia in an ipsilateral limb, it has been unclear whether TENS produces higher analgesic effects in the contralateral segmental area. The aim of present study was to investigate the analgesic effects of TENS in contralateral segmental or extra-segmental areas on physiological and subjective pain outcomes, using a nociceptive flexion reflex (NFR) method...
February 1, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30697949/assessing-the-efficacy-of-a-manual-based-intervention-for-improving-the-detection-of-facial-pain-expression
#7
Joshua A Rash, Kenneth M Prkachin, Patricia E Solomon, Tavis S Campbell
BACKGROUND: This article presents the results of a parallel-group, non-randomized, controlled study that evaluated the feasibility of an online training program for improving observer detection of facial pain expression. METHOD: Fifty-four undergraduate students attended two laboratory sessions interspersed by an intervention period where they were assigned to complete the Index of Facial Pain Expression (IFPE) - an online training environment designed to teach observers to code facial muscle movements associated with pain - or a no contact control...
January 30, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30697909/lumbosacral-radicular-pain-during-micturition-defecation-or-orgasm
#8
R Haddad, C Hentzen, F Le Breton, S Sheikh Ismael, G Amarenco
BACKGROUND: The objective of this study is to describe, in a cohort of patients followed for bladder, bowel or sexual dysfunctions, the occurrence of radicular pain during micturition, defecation and/or orgasm. METHODS: The study included all patients referred in our neuro-urology department and who suffered from radicular pain before, during or after micturition, defecation and/or orgasm. Data included demographic and medical variables, urodynamic and perineal electromyographic diagnosis...
January 30, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30697875/motor-performance-during-experimental-pain-the-influence-of-exposure-to-contact-sports
#9
C Thornton, D Sheffield, A Baird
BACKGROUND: Athletes who play contact sports are regularly exposed to pain, yet manage to perform complex tasks without significant decrement. Limited research has suggested that superior pain tolerance in contact athletes may be important in this context and this may be altered via experience of pain. Other psychological variables such as challenge states, pain bothersomeness and coping style may also influence skill execution during pain. METHODS: Forty experienced contact athletes (>3years experience), 40 novice contact athletes (<6months experience) and 40 non-contact athletes performed a motor task both in pain and without pain...
January 30, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30664322/altered-amygdalar-volume-and-functional-connectivity-in-primary-dysmenorrhea-during-the-menstrual-cycle
#10
L Yang, W H Dun, K Li, J Yang, K Wang, H J Liu, J X Liu, M Zhang
BACKGROUND: Primary dysmenorrhea (PDM), characterized as menstrual pain without pelvic pathology, is associated with pain-related negative mood and hormone fluctuations. Previous studies strongly supported the link between pain and negative mood in affected individuals; however, it remains largely unknown in patients with PDM. METHODS: We focused on the effects how spontaneous pain, negative mood and hormone levels played on the central nervous system in 34 PDM women and 33 matched healthy controls across their cycles (periovulatory phase and menstruation phase) by using T1-weighted and functional imaging...
January 21, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30663833/fibromyalgia-a-misconnection-in-a-multi-connected-world
#11
REVIEW
Serge Perrot
Fibromyalgia represents a condition still controversial in its entity, pathophysiology, diagnosis and management. In a world where everybody is connected, and everybody is sharing their own image, fibromyalgia (FM) represents the emblematic pathology of misconnection and lack of specific biomarker. FM is an invisible experience with all normal tests and analyses, without any visible biomarker to exhibit to healthcare professionals, colleagues and relatives. In this context we propose to consider FM as a disease of misconnection at different levels: misconnection with society, misconnection with healthcare professionals, misconnection with pathophysiological concepts, misconnection between brain and body...
January 21, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30648781/evaluating-the-novel-added-value-of-neurophysiological-pain-sensitivity-within-the-fear-avoidance-model-of-pain
#12
Zakir Uddin, Arthur Woznowski-Vu, Daniel Flegg, Andrea Aternali, Rebekah Wickens, Timothy H Wideman
BACKGROUND: The Fear-Avoidance Model (FAM) is a leading theoretical paradigm for explaining persistent pain following musculoskeletal injury. The model suggests that as injuries heal, pain-related outcomes are increasingly determined by psychological, rather than physiological factors. Increasing literature, however, suggests that neurophysiological processes related to pain sensitivity also play an important role in chronicity. To date, there has been limited research that has specifically explored the role of pain sensitivity within the FAM...
January 16, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30633839/trigeminal-neuropathic-pain-development-and-maintenance-in-rats-are-suppressed-by-a-positive-modulator-of-%C3%AE-6gaba-a-receptors
#13
D Vasović, B Divović, M Treven, D E Knutson, F Steudle, P Scholze, A Obradović, J Fabjan, B Brković, W Sieghart, M Ernst, J M Cook, M M Savić
GABAA receptors containing the α6 subunit are located in trigeminal ganglia, and their reduction by small interfering RNA increases inflammatory temporomandibular and myofascial pain in rats. We thus hypothesized that enhancing their activity may help in neuropathic syndromes originating from the trigeminal system. Here, we performed a detailed electrophysiological and pharmacokinetic analysis of two recently developed deuterated structurally similar pyrazoloquinolinone compounds. DK-I-56-1 at concentrations below 1 μM enhanced GABA currents at recombinant rat α6β3γ2, α6β3δ and α6β3 receptors whereas it was inactive at most GABAA receptor subtypes containing other α subunits...
January 11, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30629782/eye-movement-behaviours-when-viewing-real-world-pain-related-images
#14
Daniel E Schoth, Jun Wu, Jin Zhang, Xiaoying Guo, Christina Liossi
BACKGROUND: Pain-related cues are evolutionarily primed to capture attention, although evidence of attentional biases towards pain-related information is mixed in healthy individuals. The present study explores whether healthy individuals show significantly different eye-movement behaviours when viewing real-world pain-related scenes compared to neutral scenes. The effect of manipulating via written information the threat value of the pain-related scenes on eye-movement behaviours was also assessed...
January 10, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30620151/rewarded-placebo-analgesia-a-new-mechanism-of-placebo-effects-based-on-operant-conditioning
#15
Wacław M Adamczyk, Karolina Wiercioch-Kuzianik, Elżbieta A Bajcar, Przemysław Bąbel
BACKGROUND: Placebo analgesia is explained by two learning processes: classical conditioning and observational learning. A third learning process, operant conditioning, has not previously been investigated as a mechanism of placebo effects. We aimed to induce placebo analgesia by operant conditioning. METHODS: Three groups of participants received electrocutaneous pain stimuli of the same intensity, preceded by either an orange or blue stimulus. In the conditioning phase of the study, participants from the experimental group were rewarded for low pain responses following one of the colour stimuli (placebo) and for high pain responses following the other colour stimuli (non-placebo)...
January 8, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30620147/observers-impression-of-the-person-in-pain-influences-their-pain-estimation-and-tendency-to-help
#16
Ali Khatibi, Mahdi Mazidi
BACKGROUND: Estimation of a patient's pain may have a considerable impact on the level of care that patient receives. Many studies have shown that contextual factors may influence an observer's pain estimation. Here, we investigate the effect of an observer's impression of a person in pain and justification of his/her pain on the observer's pain estimation, tendency to help and perceived empathy. METHODS: Thirty healthy individuals (half females) read scenarios aimed to manipulate the reader's impression of characters who ultimately were fired from their work (four positive characters and four negative; half females)...
January 8, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30620145/the-effectiveness-of-self-management-interventions-in-adults-with-chronic-orofacial-pain-a-systematic-review-meta-analysis-and-meta-regression
#17
REVIEW
V R Aggarwal, Y Fu, C J Main, J Wu
BACKGROUND: Psychosocial risk factors associated with chronic orofacial pain are amenable to self-management. However, current management involves invasive therapies which lack an evidence base and have the potential to cause iatrogenic harm. OBJECTIVES: To determine: 1) whether self-management is more effective than usual care in improving pain intensity and psychosocial well-being 2) optimal components of self-management interventions. DATABASES AND DATA TREATMENT: Cochrane Oral Health Group Trials Register, Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PsycINFO, WHO International Clinical Trials Registry Platform and Clinical Trialsgov were searched...
January 8, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30620127/too-much-or-too-little-opioid-use-a-comment-on-bosetti-et-al
#18
Andréia Turmina Fontanella, Cynthia Goulart Molina-Bastos, Tatiane da Silva Dal Pizzol, Sotero Serrate Mengue
Opioids have incredible power to make lives better, as well as destroy them. After the latest US opioid overuse crisis reported by the United Nations (UN) in 2017, several other countries started observing their own opioid consumption tendencies in order to better understand current practices, predict future changes, and protect their nations if necessary. The report presented by the UN showed the use of opioid in the US as being the highest of any country in the world, and more than fifty percent higher than Germany, the second country in the rank...
January 8, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30620116/risk-of-adverse-events-in-patients-prescribed-long-term-opioids-a-cohort-study-in-the-uk-clinical-practice-research-datalink
#19
J Bedson, Y Chen, J Ashworth, R A Hayward, K M Dunn, K P Jordan
BACKGROUND: Long-term opioid prescribing for musculoskeletal pain is controversial due to uncertainty regarding effectiveness and safety. This study examined the risks of a range of adverse events in a large cohort of patients prescribed long-term opioids using the UK Clinical Practice Research Datalink. METHODS: Patients with musculoskeletal conditions starting a new long-term opioid episode (defined as ≥3 opioid prescriptions within 90 days) between 2002-2012 were included...
January 8, 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30620109/standards-for-the-diagnosis-and-management-of-complex-regional-pain-syndrome-results-of-a-european-pain-federation-task-force
#20
A Goebel, C Barker, F Birklein, F Brunner, R Casale, C Eccleston, E Eisenberg, C S McCabe, G L Moseley, R Perez, S Perrot, A Terkelsen, I Thomassen, A Zyluk, C Wells
BACKGROUND: Complex Regional Pain Syndrome is a painful and disabling post-traumatic primary pain disorder. Acute and chronic CRPS are major clinical challenges. In Europe progress is hampered by significant heterogeneity in clinical practice. We sought to establish standards for the diagnosis and management of CPRS. METHODS: The European Pain Federation established a pan-European task force of experts in CRPS who followed a four-stage consensus challenge process to produce mandatory quality standards worded as grammatically imperative (must-do) statements...
January 8, 2019: European Journal of Pain: EJP
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