Ling Qu, Xiaochun Liang, Guoqing Tian, Gaili Zhang, Qunli Wu, Xiumei Huang, Yazhong Cui, Yuling Liu, Zhufang Shen, Changqing Xiao, Yingfen Qin, Heng Miao, Yongyan Zhang, Ziling Li, Shandong Ye, Xuezhi Zhang, Jing Yang, Guiwen Cao, Yi Li, Gangyi Yang, Ji Hu, Xiaoyue Wang, Zhengfang Li, Yukun Li, Xiuzhen Zhang, Guangde Zhang, Li Chen, Wenjin Hua, Ming Yu, Chunyan Lu, Xiaomei Zhang, Hong Jiang
OBJECTIVE: This study aimed to evaluate the efficacy and safety of mulberry twig alkaloids (Sangzhi alkaloids [SZ-A]) in the treatment of type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: This was a multicenter, randomized, double-blind, double-dummy, and parallel controlled noninferiority clinical trial that was conducted for 24 weeks. A total of 600 patients were randomly allocated to the SZ-A group ( n = 360) or acarbose group ( n = 240). The primary efficacy end point was the change of glycosylated hemoglobin (HbA1c ) compared with baseline...
April 8, 2021: Diabetes Care
Shan Luo, Brendan C Angelo, Ting Chow, John R Monterosso, Paul M Thompson, Anny H Xiang, Kathleen A Page
OBJECTIVE: Children exposed to gestational diabetes mellitus (GDM) or maternal obesity in utero have an increased propensity to develop obesity. Little is known about the mechanisms underlying this phenomenon. We aimed to examine relationships between exposure to GDM or maternal obesity and daily energy intake (EI), brain responses to food cues within reward regions, and adiposity in children. RESEARCH DESIGN AND METHODS: Participants were 159 children ages 7-11 years...
April 7, 2021: Diabetes Care
Yawa Abouleka, Kamel Mohammedi, Charlyne Carpentier, Severine Dubois, Pierre Gourdy, Jean-François Gautier, Ronan Roussel, André Scheen, François Alhenc-Gelas, Samy Hadjadj, Gilberto Velho, Michel Marre
No abstract text is available yet for this article.
April 7, 2021: Diabetes Care
Xilin Zhou, Linda J Andes, Deborah B Rolka, Giuseppina Imperatore, Stephen R Benoit
No abstract text is available yet for this article.
April 7, 2021: Diabetes Care
Beate Karges, Nicole Prinz, Kerstin Placzek, Nicolin Datz, Matthias Papsch, Ursula Strier, Dirk Agena, Walter Bonfig, Heiner Kentrup, Reinhard W Holl
OBJECTIVE: To investigate natural course, treatment, and outcomes in familial versus sporadic type 1 diabetes. RESEARCH DESIGN AND METHODS: In a population-based study, we compared patients with onset of type 1 diabetes before the age of 20 years who had a first-degree relative with type 1 diabetes (familial diabetes) with patients with type 1 diabetes who had no first-degree relative with type 1 diabetes (sporadic diabetes) at diagnosis and over the first 10 treatment years, using multivariable regression and proportional hazards models...
April 6, 2021: Diabetes Care
Ashley E Tate, Shengxin Liu, Ruyue Zhang, Zeynep Yilmaz, Janne T Larsen, Liselotte V Petersen, Cynthia M Bulik, Ann-Marie Svensson, Soffia Gudbjörnsdottir, Henrik Larsson, Agnieszka Butwicka, Ralf Kuja-Halkola
OBJECTIVE: To ascertain the association and coaggregation of eating disorders and childhood-onset type 1 diabetes in families. RESEARCH DESIGN AND METHODS: Using population samples from national registers in Sweden ( n = 2,517,277) and Demark ( n = 1,825,920), we investigated the within-individual association between type 1 diabetes and eating disorders and their familial coaggregation among full siblings, half siblings, full cousins, and half cousins. On the basis of clinical diagnoses, we classified eating disorders into any eating disorder (AED), anorexia nervosa (AN) and atypical AN, and other eating disorder (OED)...
April 6, 2021: Diabetes Care
Kiran K Chatha, Brad Walsh, Javier La Fontaine, Michael E Bowen, Luigi Meneghini
No abstract text is available yet for this article.
April 6, 2021: Diabetes Care
Keith M Godfrey, Sheila J Barton, Sarah El-Heis, Timothy Kenealy, Heidi Nield, Philip N Baker, Yap Seng Chong, Wayne Cutfield, Shiao-Yng Chan
OBJECTIVE: Better preconception metabolic and nutritional health are hypothesized to promote gestational normoglycemia and reduce preterm birth, but evidence supporting improved outcomes with nutritional supplementation starting preconception is limited. RESEARCH DESIGN AND METHODS: This double-blind randomized controlled trial recruited from the community 1,729 U.K., Singapore, and New Zealand women aged 18-38 years planning conception. We investigated whether a nutritional formulation containing myo -inositol, probiotics, and multiple micronutrients (intervention), compared with a standard micronutrient supplement (control), taken preconception and throughout pregnancy could improve pregnancy outcomes...
March 29, 2021: Diabetes Care
Anita Jeyam, Helen Colhoun, Stuart McGurnaghan, Luke Blackbourn, Timothy J McDonald, Colin N A Palmer, John A McKnight, Mark W J Strachan, Alan W Patrick, John Chalmers, Robert S Lindsay, John R Petrie, Sandeep Thekkepat, Andrew Collier, Sandra MacRury, Paul M McKeigue
No abstract text is available yet for this article.
March 17, 2021: Diabetes Care
Gregory G Schwartz, Michael Szarek, Vera A Bittner, Deepak L Bhatt, Rafael Diaz, Shaun G Goodman, J Wouter Jukema, Megan Loy, Garen Manvelian, Robert Pordy, Harvey D White, Philippe Gabriel Steg
OBJECTIVE: In observational data, lower levels of lipoprotein(a) have been associated with greater prevalence of type 2 diabetes. Whether pharmacologic lowering of lipoprotein(a) influences incident type 2 diabetes is unknown. We determined the relationship of lipoprotein(a) concentration with incident type 2 diabetes and effects of treatment with alirocumab, a PCSK9 inhibitor. RESEARCH DESIGN AND METHODS: In the ODYSSEY OUTCOMES trial alirocumab was compared with placebo in patients with acute coronary syndrome...
March 15, 2021: Diabetes Care
Matthew M Y Lee, Nazim Ghouri, Darren K McGuire, Martin K Rutter, Naveed Sattar
BACKGROUND: Results of cardiovascular outcome trials (CVOTs) suggest Asians may derive greater benefit than Whites from newer classes of antihyperglycemic medications. PURPOSE: To provide summary hazard ratio (HR) estimates for cardiovascular efficacy of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide receptor agonists (GLP-1RAs) stratified by race (Asian vs. White). DATA SOURCES: A systematic review performed in PubMed from 1 January 2015 to 8 December 2020...
March 11, 2021: Diabetes Care
Michael P Bancks, Haiying Chen, Ashok Balasubramanyam, Alain G Bertoni, Mark A Espeland, Steven E Kahn, Scott Pilla, Elizabeth Vaughan, Lynne E Wagenknecht
OBJECTIVE: We reevaluated the Action for Health in Diabetes (Look AHEAD) intervention, incorporating diabetes subgroups, to identify whether intensive lifestyle intervention (ILI) is associated with differential risk for cardiovascular disease (CVD) by diabetes subgroup. RESEARCH DESIGN AND METHODS: In the Look AHEAD trial, 5,145 participants, aged 45-76 years, with type 2 diabetes (T2D) and overweight or obesity were randomly assigned to 10 years of ILI or a control condition of diabetes support and education...
March 11, 2021: Diabetes Care
Line Hjort, Louise Groth Grunnet, Richard Saffery, Sjurdur Olsen, Allan Vaag
No abstract text is available yet for this article.
March 8, 2021: Diabetes Care
Frank Qian, Andres V Ardisson Korat, Fumiaki Imamura, Matti Marklund, Nathan Tintle, Jyrki K Virtanen, Xia Zhou, Julie K Bassett, Heidi Lai, Yoichiro Hirakawa, Kuo-Liong Chien, Alexis C Wood, Maria Lankinen, Rachel A Murphy, Cecilia Samieri, Kamalita Pertiwi, Vanessa D de Mello, Weihua Guan, Nita G Forouhi, Nick Wareham, InterAct Consortium Frank B Hu, Ulf Riserus, Lars Lind, William S Harris, Aladdin H Shadyab, Jennifer G Robinson, Lyn M Steffen, Allison Hodge, Graham G Giles, Toshiharu Ninomiya, Matti Uusitupa, Jaakko Tuomilehto, Jaana Lindström, Markku Laakso, David S Siscovick, Catherine Helmer, Johanna M Geleijnse, Jason H Y Wu, Amanda Fretts, Rozenn N Lemaitre, Renata Micha, Dariush Mozaffarian, Qi Sun
OBJECTIVE: Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS: For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries...
March 3, 2021: Diabetes Care
Avivit Cahn, Itamar Raz, Lawrence A Leiter, Ofri Mosenzon, Sabina A Murphy, Erica L Goodrich, Ilan Yanuv, Aliza Rozenberg, Deepak L Bhatt, Darren K McGuire, John P H Wilding, Ingrid A M Gause-Nilsson, Anna Maria Langkilde, Marc S Sabatine, Stephen D Wiviott
OBJECTIVE: International guidelines propose prescribing sodium-glucose cotransporter 2 (SGLT2) inhibitors to patients with type 2 diabetes (T2D) as secondary prevention in patients with established atherosclerotic cardiovascular disease (ASCVD) or for primary prevention of cardiovascular events in high-risk patients with multiple risk factors (MRF) for ASCVD. The current analyses expand on the cardiovascular renal and metabolic effects of SGLT2 inhibitors in MRF patients. RESEARCH DESIGN AND METHODS: In DECLARE-TIMI 58, 17,160 patients with T2D and MRF (59...
March 2, 2021: Diabetes Care
Emily D Szmuilowicz, Grazia Aleppo
No abstract text is available yet for this article.
March 2, 2021: Diabetes Care
Robin Kristófi, Johan Bodegard, Anna Norhammar, Marcus Thuresson, David Nathanson, Thomas Nyström, Kåre I Birkeland, Jan W Eriksson
OBJECTIVE: Type 1 diabetes (T1D) and type 2 diabetes (T2D) increase risks of cardiovascular (CV) and renal disease (CVRD) compared with diabetes-free populations. Direct comparisons between T1D and T2D are scarce. We examined this by pooling full-population cohorts in Sweden and Norway. RESEARCH DESIGN AND METHODS: A total of 59,331 patients with T1D and 484,241 patients with T2D, aged 18-84 years, were followed over a mean period of 2.6 years from 31 December 2013...
March 2, 2021: Diabetes Care
Roque Cardona-Hernandez, Anke Schwandt, Hessa Alkandari, Heiko Bratke, Agata Chobot, Nicole Coles, Sarah Corathers, Damla Goksen, Peter Goss, Zineb Imane, Katrin Nagl, Stephen M P O'Riordan, Craig Jefferies
OBJECTIVE: Insulin delivery methods, glucose-monitoring modalities, and related outcomes were examined in a large, international, diverse cohort of children and adolescents with type 1 diabetes from the Better Control in Pediatric and Adolescent Diabetes: Working to Create Centers of Reference (SWEET) -Registry. RESEARCH DESIGN AND METHODS: Participants with type 1 diabetes of ≥1 year, aged ≤18 years, and who had documented pump or sensor usage during the period August 2017-July 2019 were stratified into four categories: injections-no sensor (referent); injections + sensor; pump-no sensor; and pump + sensor...
March 2, 2021: Diabetes Care
Hertzel C Gerstein, Chinthanie Ramasundarahettige, Shrikant I Bangdiwala
No abstract text is available yet for this article.
February 25, 2021: Diabetes Care
Sareh Keshavarzi, Barbara H Braffett, Rodica Pop-Busui, Trevor J Orchard, Elsayed Z Soliman, Gayle M Lorenzi, Annette Barnie, Amy B Karger, Rose A Gubitosi-Klug, Samuel Dagogo-Jack, Andrew D Paterson
OBJECTIVE: Individuals with diabetes have higher resting heart rate compared with those without, which may be predictive of long-term cardiovascular disease (CVD) risk. Using data from the DCCT/EDIC study, we evaluated whether the beneficial effect of intensive versus conventional diabetes therapy on heart rate persisted, the factors mediating the differences in heart rate between treatment groups, and the effects of heart rate on future CVD risk. RESEARCH DESIGN AND METHODS: Longitudinal changes in heart rate, from annual electrocardiograms over 22 years of EDIC follow-up, were evaluated in 1,402 participants with type 1 diabetes...
February 25, 2021: Diabetes Care
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