journal
https://read.qxmd.com/read/36944118/cardiovascular-safety-in-type-2-diabetes-with-sulfonylureas-as-second-line-drugs-a-nation-wide-population-based-comparative-safety-study
#1
JOURNAL ARTICLE
Huan Wang, Ruth L M Cordiner, Yu Huang, Louise Donnelly, Simona Hapca, Andrew Collier, John McKnight, Brian Kennon, Fraser Gibb, Paul McKeigue, Sarah H Wild, Helen Colhoun, John Chalmers, John Petrie, Naveed Sattar, Thomas MacDonald, Rory J McCrimmon, Daniel R Morales, Ewan R Pearson
OBJECTIVE: To assess the real-world cardiovascular (CV) safety for sulfonylureas (SU), in comparison with dipeptidylpeptidase-4 inhibitors (DPP4i) and thiazolidinediones (TZD), through development of robust methodology for causal inference in a whole nation study. RESEARCH DESIGN AND METHODS: A cohort study was performed including people with type 2 diabetes diagnosed in Scotland before 31 December 2017, who failed to reach HbA1c 48 mmol/mol despite metformin monotherapy and initiated second-line pharmacotherapy (SU/DPP4i/TZD) on or after 1 January 2010...
March 21, 2023: Diabetes Care
https://read.qxmd.com/read/36944059/once-weekly-basal-insulin-fc-demonstrated-similar-glycemic-control-to-once-daily-insulin-degludec-in-insulin-naive-patients-with-type-2-diabetes-a-phase-2-randomized-control-trial
#2
JOURNAL ARTICLE
Juliana M Bue-Valleskey, Christof M Kazda, Chenchen Ma, Jenny Chien, Qianyi Zhang, Emmanuel Chigutsa, William Landschulz, Axel Haupt, Juan P Frias
OBJECTIVE: Basal insulin Fc (BIF) (insulin efsitora alfa; LY3209590), a fusion protein combining a novel single-chain insulin variant with a human IgG Fc domain, is designed for once-weekly basal insulin administration. This phase 2 study assessed the safety and efficacy of BIF versus degludec in insulin-naive patients with type 2 diabetes (T2D) previously treated with oral antihyperglycemic medications. RESEARCH DESIGN AND METHODS: During this randomized, parallel, open-label study, 278 insulin-naive patients with T2D were randomly assigned (1:1) to receive BIF once weekly or degludec once daily over the 26-week treatment period...
March 21, 2023: Diabetes Care
https://read.qxmd.com/read/36939558/earlier-age-at-type-2-diabetes-diagnosis-is-associated-with-increased-genetic-risk-of-cardiovascular-disease
#3
JOURNAL ARTICLE
Hyunsuk Lee, Jaewon Choi, Na Yeon Kim, Jong-Il Kim, Min Kyong Moon, Seunggeun Lee, Kyong Soo Park, Soo Heon Kwak
OBJECTIVE: We investigated genetic risk of cardiovascular disease (CVD) by age at type 2 diabetes (T2D) diagnosis. RESEARCH DESIGN AND METHODS: We compared incident CVD events by age at T2D diagnosis using UK Biobank (N = 12,321) and the Seoul National University Hospital (SNUH) cohort (N = 1,165). Genetic risk was quantified using polygenic risk score (PRS). RESULTS: Individuals with earlier T2D diagnosis had higher CVD risk. In UK Biobank, the effect size of coronary artery disease (CAD) PRS on incident CAD was largest in individuals diagnosed with T2D at ages 30-39 years (hazard ratio 2...
March 20, 2023: Diabetes Care
https://read.qxmd.com/read/36930723/development-and-validation-of-a-diabetic-retinopathy-risk-stratification-algorithm
#4
JOURNAL ARTICLE
Dariusz Tarasewicz, Andrew J Karter, Noel Pimentel, Howard H Moffet, Khanh K Thai, David Schlessinger, Oleg Sofrygin, Ronald B Melles
OBJECTIVE: Although diabetic retinopathy is a leading cause of blindness worldwide, diabetes-related blindness can be prevented through effective screening, detection, and treatment of disease. The study goal was to develop risk stratification algorithms for the onset of retinal complications of diabetes, including proliferative diabetic retinopathy, referable retinopathy, and macular edema. RESEARCH DESIGN AND METHODS: Retrospective cohort analysis of patients from the Kaiser Permanente Northern California Diabetes Registry who had no evidence of diabetic retinopathy at a baseline diabetic retinopathy screening during 2008-2020 was performed...
March 17, 2023: Diabetes Care
https://read.qxmd.com/read/36930691/crp-c-peptide-and-risk-of-first-time-cardiovascular-events-and-mortality-in-early-type-2-diabetes-a-danish-cohort-study
#5
JOURNAL ARTICLE
Anne Gedebjerg, Mette Bjerre, Alisa Devedzic Kjaergaard, Jens Steen Nielsen, Jørgen Rungby, Ivan Brandslund, Michael Maeng, Henning Beck-Nielsen, Allan Vaag, Henrik Toft Sørensen, Troels Krarup Hansen, Reimar Wernich Thomsen
OBJECTIVE: We investigated the relationship between hs-CRP, a marker of low-grade inflammation, alone or in combination with C-peptide, a marker of hyperinsulinemia/insulin resistance, and risk for cardiovascular events (CVEs) and mortality in patients recently diagnosed with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: In patients with recent-onset T2D, we measured serum hs-CRP (n = 7,301) and C-peptide (n = 5,765) in the prospective Danish Centre for Strategic Research in Type 2 Diabetes cohort study...
March 17, 2023: Diabetes Care
https://read.qxmd.com/read/36928320/psychiatric-morbidity-in-women-with-previous-gestational-diabetes-mellitus-a-nationwide-register-based-cohort-study
#6
JOURNAL ARTICLE
Maria Hornstrup Christensen, Marianne Skovsager Andersen, Katrine Hass Rubin, Ellen Aagaard Nohr, Jori Aalders, Christina Anne Vinter, Dorte Moeller Jensen
OBJECTIVE: To investigate associations between previous gestational diabetes mellitus (GDM) and incident psychiatric morbidity, and to explore the role of subsequent diabetes development in psychiatric morbidity risk. RESEARCH DESIGN AND METHODS: A nationwide register-based cohort study including all women delivering in Denmark from 1997 to 2018 was conducted. GDM exposure was based on diagnosis code, whereas psychiatric morbidity outcome was based on diagnosis code and psychopharmacological medication use...
March 16, 2023: Diabetes Care
https://read.qxmd.com/read/36928113/impact-of-early-life-factors-on-metabolic-phenotypes-of-obesity-in-preschool-children
#7
JOURNAL ARTICLE
Zijun Liao, Xianghui Xie, Jing Wang, Yiren Chen, Ting Zhang, Gongshu Liu, Fangfang Chen
OBJECTIVE: To investigate the impact of factors in the first 1,000 days of life on metabolic phenotypes of obesity in preschool children in a cohort study. RESEARCH DESIGN AND METHODS: We recruited 3-year-old children for the study. Early life factors included maternal age at delivery, maternal education, prepregnancy BMI, gestational weight gain, gravidity, history of gestational diabetes mellitus, delivery mode, gestational age, family history of metabolic disorders, paternal education, annual family income, child sex, birth weight, and breastfeeding duration...
March 16, 2023: Diabetes Care
https://read.qxmd.com/read/36920867/novel-once-weekly-basal-insulin-fc-achieved-similar-glycemic-control-with-a-safety-profile-comparable-to-insulin-degludec-in-patients-with-type-1-diabetes
#8
JOURNAL ARTICLE
Christof M Kazda, Juliana M Bue-Valleskey, Jenny Chien, Qianyi Zhang, Emmanuel Chigutsa, William Landschulz, Paula Wullenweber, Axel Haupt, Dominik Dahl
OBJECTIVE: Basal Insulin Fc (BIF; insulin efsitora alfa; LY3209590), a fusion protein combining a novel single-chain insulin variant with a human IgG Fc domain, is designed for once-weekly basal insulin administration. This phase 2 study assessed safety and efficacy of BIF versus degludec in 265 patients with type 1 diabetes (T1D) using multiple daily injections. RESEARCH DESIGN AND METHODS: During this randomized, parallel, open-label study, patients with T1D were randomized (1:1) to receive BIF once weekly or degludec once daily over the 26-week treatment period...
March 15, 2023: Diabetes Care
https://read.qxmd.com/read/36920843/potential-and-pitfalls-of-chatgpt-and-natural-language-artificial-intelligence-models-for-diabetes-education
#9
JOURNAL ARTICLE
Gerald Gui Ren Sng, Joshua Yi Min Tung, Daniel Yan Zheng Lim, Yong Mong Bee
No abstract text is available yet for this article.
March 15, 2023: Diabetes Care
https://read.qxmd.com/read/36920750/personalized-virtual-care-using-continuous-glucose-monitoring-in-adults-with-type-2-diabetes-treated-with-less-intensive-therapies
#10
JOURNAL ARTICLE
Sushma Reddy, Calvin C Wu, Aimée José, Jennifer L Hsieh, Shetal Desai Rautela
No abstract text is available yet for this article.
March 15, 2023: Diabetes Care
https://read.qxmd.com/read/36920087/abatacept-for-delay-of-type-1-diabetes-progression-in-stage-1-relatives-at-risk-a-randomized-double-masked-controlled-trial
#11
JOURNAL ARTICLE
William E Russell, Brian N Bundy, Mark S Anderson, Laura A Cooney, Stephen E Gitelman, Robin S Goland, Peter A Gottlieb, Carla J Greenbaum, Michael J Haller, Jeffrey P Krischer, Ingrid M Libman, Peter S Linsley, S Alice Long, Sandra M Lord, Daniel J Moore, Wayne V Moore, Antoinette M Moran, Andrew B Muir, Philip Raskin, Jay S Skyler, John M Wentworth, Diane K Wherrett, Darrell M Wilson, Anette-Gabriele Ziegler, Kevan C Herold
OBJECTIVE: Previous studies showed that inhibiting lymphocyte costimulation reduces declining β-cell function in individuals newly diagnosed with type 1 diabetes. We tested whether abatacept would delay or prevent progression of type 1 diabetes from normal glucose tolerance (NGT) to abnormal glucose tolerance (AGT) or to diabetes and the effects of treatment on immune and metabolic responses. RESEARCH DESIGN AND METHODS: We conducted a phase 2, randomized, placebo-controlled, double-masked trial of abatacept in antibody-positive participants with NGT who received monthly abatacept/placebo infusions for 12 months...
March 15, 2023: Diabetes Care
https://read.qxmd.com/read/36897834/biomarker-changes-associated-with-both-dulaglutide-and-cardiovascular-events-in-the-rewind-randomized-controlled-trial-a-nested-case-control-post-hoc-analysis
#12
JOURNAL ARTICLE
Hertzel C Gerstein, Shun-Fu Lee, Guillaume Paré, M Angelyn Bethel, Helen M Colhoun, Anastasia Hoover, Mark Lakshmanan, Yanzhu Lin, Valentino Pirro, Hui-Rong Qian, Giacomo Ruotolo, Lars Ryden, Jonathan M Wilson, Kevin L Duffin
OBJECTIVE: The glucagon-like peptide-1 receptor agonist dulaglutide reduced MACE in the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial. This paper expores the relationship of selected biomarkers to both dulaglutide and major adverse cardiovascular events (MACE). RESEARCH DESIGN AND METHODS: In this post hoc analysis, stored fasting baseline and 2-year plasma samples from 824 REWIND participants with MACE during follow-up and 845 matched non-MACE participants were analyzed for 2-year changes in 19 protein biomarkers...
March 10, 2023: Diabetes Care
https://read.qxmd.com/read/36884283/evaluation-of-the-clinical-impact-of-dapagliflozin-discontinuation-as-adjunctive-therapy-for-patients-with-type-1-diabetes-after-indication-withdrawal-a-two-center-retrospective-study
#13
JOURNAL ARTICLE
José Ignacio Martínez-Montoro, María José Picón-César, Víctor José Simón-Frapolli, José Luis Pinzón-Martín, Jorge García-Alemán, María Durán-Martínez, Francisco J Tinahones
No abstract text is available yet for this article.
March 8, 2023: Diabetes Care
https://read.qxmd.com/read/36883290/diabetes-stigma-and-clinical-outcomes-in-adolescents-and-young-adults-the-search-for-diabetes-in-youth-study
#14
JOURNAL ARTICLE
Kelsey B Eitel, Alissa J Roberts, Ralph D'Agostino, Catherine E Barrett, Ronny A Bell, Anna Bellatorre, Angelica Cristello, Dana Dabelea, Lawrence M Dolan, Elizabeth T Jensen, Angela D Liese, Elizabeth J Mayer-Davis, Kristi Reynolds, Santica M Marcovina, Catherine Pihoker
OBJECTIVE: To examine the association between diabetes stigma and HbA1c, treatment plan and acute and chronic complications in adolescents and young adults (AYAs) with type 1 or type 2 diabetes. RESEARCH DESIGN AND METHODS: The SEARCH for Diabetes in Youth study is a multicenter cohort study that collected questionnaire, laboratory, and physical examination data about AYAs with diabetes diagnosed in childhood. A five-question survey assessed frequency of perceived diabetes-related stigma, generating a total diabetes stigma score...
March 8, 2023: Diabetes Care
https://read.qxmd.com/read/36867461/incidence-of-lada-and-type-2-diabetes-in-relation-to-tobacco-use-and-genetic-susceptibility-to-type-2-diabetes-and-related-traits-findings-from-a-swedish-case-control-study-and-the-norwegian-hunt-study
#15
JOURNAL ARTICLE
Jessica Edstorp, Emma Ahlqvist, Lars Alfredsson, Dina Mansour Aly, Valdemar Grill, Bahareh Rasouli, Elin P Sørgjerd, Tiinamaija Tuomi, Bjørn O Åsvold, Sofia Carlsson
OBJECTIVE: Smoking and Swedish smokeless tobacco (snus) are associated with latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D). Our aim was to investigate whether genetic susceptibility to T2D, insulin resistance (IR), and insulin secretion (IS) aggravate these associations. RESEARCH DESIGN AND METHODS: We used data from two population-based Scandinavian studies with case subjects with LADA (n = 839) and T2D (n = 5,771), matched control subjects (n = 3,068), and 1,696,503 person-years at risk...
March 3, 2023: Diabetes Care
https://read.qxmd.com/read/36867433/interaction-between-dietary-iron-intake-and-genetically-determined-iron-overload-risk-of-islet-autoimmunity-and-progression-to-type-1-diabetes-in-the-teddy-study
#16
JOURNAL ARTICLE
Steffen U Thorsen, Xiang Liu, Yachana Kataria, Thomas Mandrup-Poulsen, Simranjeet Kaur, Ulla Uusitalo, Suvi M Virtanen, Jill M Norris, Marian Rewers, William Hagopian, Jimin Yang, Jin-Xiong She, Beena Akolkar, Stephen Rich, Carin Andrén Aronsson, Åke Lernmark, Anette-Gabriele Ziegler, Jorma Toppari, Jeffrey Krischer, Hemang M Parikh, Christina Ellervik, Jannet Svensson
OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron...
March 3, 2023: Diabetes Care
https://read.qxmd.com/read/36862942/refining-the-definition-of-stage-1-type-1-diabetes-an-ontology-driven-analysis-of-the-heterogeneity-of-multiple-islet-autoimmunity
#17
JOURNAL ARTICLE
Brigitte I Frohnert, Mohamed Ghalwash, Ying Li, Kenney Ng, Jessica L Dunne, Markus Lundgren, William Hagopian, Olivia Lou, Christiane Winkler, Jorma Toppari, Riitta Veijola, Vibha Anand
OBJECTIVE: To estimate the risk of progression to stage 3 type 1 diabetes based on varying definitions of multiple islet autoantibody positivity (mIA). RESEARCH DESIGN AND METHODS: Type 1 Diabetes Intelligence (T1DI) is a combined prospective data set of children from Finland, Germany, Sweden, and the U.S. who have an increased genetic risk for type 1 diabetes. Analysis included 16,709 infants-toddlers enrolled by age 2.5 years and comparison between groups using Kaplan-Meier survival analysis...
March 2, 2023: Diabetes Care
https://read.qxmd.com/read/36862940/impact-of-overnight-glucose-on-next-day-functioning-in-adults-with-type-1-diabetes-an-exploratory-intensive-longitudinal-study
#18
JOURNAL ARTICLE
Elizabeth A Pyatak, Donna Spruijt-Metz, Stefan Schneider, Raymond Hernandez, Loree T Pham, Claire J Hoogendoorn, Anne L Peters, Jill Crandall, Haomiao Jin, Pey-Jiuan Lee, Jeffrey S Gonzalez
OBJECTIVE: While there is evidence that functioning, or ability to perform daily life activities, can be adversely influenced by type 1 diabetes, the impact of acute fluctuations in glucose levels on functioning is poorly understood. RESEARCH DESIGN AND METHODS: Using dynamic structural equation modeling, we examined whether overnight glucose (coefficient of variation[CV], percent time <70 mg/dL, percent time >250 mg/dL) predicted seven next-day functioning outcomes (mobile cognitive tasks, accelerometry-derived physical activity, self-reported activity participation) in adults with type 1 diabetes...
March 2, 2023: Diabetes Care
https://read.qxmd.com/read/36857477/tirzepatide-reduces-appetite-energy-intake-and-fat-mass-in-people-with-type-2-diabetes
#19
JOURNAL ARTICLE
Tim Heise, J Hans DeVries, Shweta Urva, Jing Li, Edward J Pratt, Melissa K Thomas, Kieren J Mather, Chrisanthi A Karanikas, Julia Dunn, Axel Haupt, Zvonko Milicevic, Tamer Coskun
OBJECTIVE: To evaluate the effects of tirzepatide on body composition, appetite, and energy intake to address the potential mechanisms involved in body weight loss with tirzepatide. RESEARCH DESIGN AND METHODS: In a secondary analysis of a randomized, double-blind, parallel-arm study, the effects of tirzepatide 15 mg (N = 45), semaglutide 1 mg (N = 44), and placebo (N = 28) on body weight and composition, appetite, and energy intake were assessed at baseline and week 28...
March 1, 2023: Diabetes Care
https://read.qxmd.com/read/36857415/distinct-mechanisms-responsible-for-the-increase-in-glucose-production-and-ketone-formation-caused-by-empagliflozin-in-t2dm-patients
#20
JOURNAL ARTICLE
Siham Abdelgani, Ahmad Khatab, John Adams, Mohamed Abu-Farha, Guisepe Daniele, Fahd Al-Mulla, Stefano Del Prato, Ralph A DeFronzo, Muhammad Abdul-Ghani
OBJECTIVE: To examine the mechanisms responsible for the increase in glucose and ketone production caused by empagliflozin in patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: Twelve subjects with T2DM participated in two studies performed in random order. In study 1, endogenous glucose production (EGP) was measured with 8-h infusion of 6,6,D2-glucose. Three hours after the start of 6,6,D2-glucose infusion, subjects ingested 25 mg empagliflozin (n = 8) or placebo (n = 4), and norepinephrine (NE) turnover was measured before and after empagliflozin ingestion with 3H-NE infusion...
March 1, 2023: Diabetes Care
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