journal
https://read.qxmd.com/read/36448932/efficacy-of-a-connected-insulin-pen-cap-in-people-with-noncontrolled-type-1-diabetes-a-multicenter-randomized-clinical-trial
#1
JOURNAL ARTICLE
Fernando Gomez-Peralta, Cristina Abreu, Elsa Fernández-Rubio, Laura Cotovad, Pedro Pujante, Sonia Gaztambide, Diego Bellido, Edelmiro Menéndez Torre, Santiago Ruiz-Valdepeñas, Hugo Bello, Xoan Valledor, Jesús Pérez-González, Luis Ruiz-Valdepeñas
OBJECTIVE: To assess the efficacy of the insulin pen cap Insulclock on improving glycemic control, treatment adherence, and user satisfaction in people with type 1 diabetes. RESEARCH DESIGN AND METHODS: This multicenter, open-label, randomized controlled trial comprised a 4-week run-in phase and a 6-week double-arm phase in which participants were randomly assigned into an active or masked mode. RESULTS: Fifty-five participants were evaluable (active group, n = 26, masked group, n = 29)...
November 30, 2022: Diabetes Care
https://read.qxmd.com/read/36409604/long-term-weight-training-and-mortality-in-u-s-male-health-professionals-with-and-without-type-2-diabetes
#2
JOURNAL ARTICLE
Dong Hoon Lee, Xiao Luo, Leandro F M Rezende, Hee-Kyung Joh, NaNa Keum, Eric B Rimm, Fred K Tabung, Xuehong Zhang, Edward L Giovannucci
OBJECTIVE: To investigate the relationship between long-term weight training and mortality in male health professionals with and without type 2 diabetes. RESEARCH DESIGN AND METHODS: We analyzed 31,140 men without type 2 diabetes and 2,588 with type 2 diabetes from the Health Professionals Follow-up Study (1992-2018). Information on weight training was repeatedly assessed using a biennial questionnaire. Cox regression was used to estimate hazard ratios (HRs) and 95% CIs...
November 21, 2022: Diabetes Care
https://read.qxmd.com/read/36399782/incident-early-and-later-onset-type-2-diabetes-and-risk-of-early-and-later-onset-cancer-prospective-cohort-study
#3
JOURNAL ARTICLE
Yin Zhang, Mingyang Song, Yin Cao, A Heather Eliassen, Brian M Wolpin, Meir J Stampfer, Walter C Willett, Kana Wu, Kimmie Ng, Frank B Hu, Edward L Giovannucci
OBJECTIVE: We evaluated prospectively the association between incident early- (diagnosed before 40 years of age) and later-onset type 2 diabetes and early- (diagnosed before 50 years of age) and later-onset cancer risk. RESEARCH DESIGN AND METHODS: We prospectively followed 228,073 eligible participants in the Nurses' Health Studies for up to 38 years. Hazard ratios (HRs) and 95% CI were estimated using Cox models. RESULTS: We documented 18,290 type 2 diabetes, 6,520 early-onset cancer, and 36,907 later-onset cancer cases during follow-up...
November 18, 2022: Diabetes Care
https://read.qxmd.com/read/36399781/association-of-estimated-glomerular-filtration-rate-with-progression-of-albuminuria-in-individuals-with-type-2-diabetes
#4
JOURNAL ARTICLE
Ko Hanai, Tomomi Mori, Yui Yamamoto, Naoshi Yoshida, Hidekazu Murata, Tetsuya Babazono
OBJECTIVE: To elucidate the association of glomerular filtration rate (GFR) at baseline with subsequent progression of albuminuria in individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS: This was a single-center retrospective cohort study of 6,618 Japanese adults with type 2 diabetes and urinary albumin-to-creatinine ratio of <300 mg/g, comprising 2,459 women and 4,159 men with a mean (± SD) age of 60 ± 12 years. The exposure was baseline estimated GFR (eGFR) (mL/min/1...
November 18, 2022: Diabetes Care
https://read.qxmd.com/read/36399777/the-impact-of-carbamylation-and-anemia-on-hba1c-s-association-with-renal-outcomes-in-patients-with-diabetes-and-chronic-kidney-disease
#5
JOURNAL ARTICLE
Mengyao Tang, Anders Berg, Eugene P Rhee, Andrew S Allegretti, Sagar Nigwekar, S Ananth Karumanchi, James P Lash, Sahir Kalim
OBJECTIVE: Glycated hemoglobin (HbA1c) can predict risk for microvascular complications in patients with diabetes. However, HbA1c's reliability in chronic kidney disease (CKD) has been questioned, with concerns including competition from another posttranslational protein modification, carbamylation, acting on the same amino groups as glycation, and anemia with reduced erythrocyte lifespans leading to altered glycation accumulation. We investigated whether carbamylation and anemia modify the impact of HbA1c on renal outcomes in patients with diabetes and CKD...
November 18, 2022: Diabetes Care
https://read.qxmd.com/read/36399763/prognosis-after-first-ever-myocardial-infarction-in-type-1-diabetes-is-strongly-affected-by-chronic-kidney-disease
#6
JOURNAL ARTICLE
Patrik Smidtslund, Fanny Jansson Sigfrids, Anni Ylinen, Nina Elonen, Valma Harjutsalo, Per-Henrik Groop, Lena M Thorn
OBJECTIVE: To study prognosis after a first-ever myocardial infarction (MI) in type 1 diabetes, as well as how different MI- and diabetes-related factors affect the prognosis and risk of secondary cardiovascular events. RESEARCH DESIGN AND METHODS: In this observational follow-up study of 4,217 individuals from the Finnish Diabetic Nephropathy (FinnDiane) Study with no prior MI or coronary revascularization, we verified 253 (6.0%) MIs from medical records or death certificates...
November 18, 2022: Diabetes Care
https://read.qxmd.com/read/36399721/efficacy-and-safety-of-dapagliflozin-by-baseline-insulin-regimen-and-dose-post-hoc-analyses-from-declare-timi-58
#7
JOURNAL ARTICLE
Rena Pollack, Itamar Raz, Stephen D Wiviott, Erica L Goodrich, Sabina A Murphy, Ilan Yanuv, Aliza Rozenberg, Ofri Mosenzon, Anna Maria Langkilde, Ingrid A M Gause-Nilsson, Deepak L Bhatt, Lawrence A Leiter, Darren K McGuire, John P H Wilding, Marc S Sabatine, Avivit Cahn
OBJECTIVE: The cardiorenal benefits of adding sodium-glucose cotransporter 2 (SGLT2) inhibitor therapy for patients on insulin, particularly those on intensive regimens that include short-acting (SA) insulin, have not been explored. RESEARCH DESIGN AND METHODS: In Dapagliflozin Effect on Cardiovascular Events trial (DECLARE-TIMI 58), 17,160 patients with type 2 diabetes were randomized to dapagliflozin or placebo for a median follow-up of 4.2 years. Cardiovascular (CV), renal, metabolic, and safety outcomes with dapagliflozin versus placebo by insulin dose and regimen were studied with Cox regression models...
November 18, 2022: Diabetes Care
https://read.qxmd.com/read/36399717/effect-of-a-mobile-health-technology-based-diabetes-education-program-on-glucose-control-in-patients-with-type-2-diabetes-initiating-premixed-insulin-a-prospective-multicenter-observational-study
#8
JOURNAL ARTICLE
Si Chen, Jingyi Lu, Danfeng Peng, Fengjing Liu, Wei Lu, Wei Zhu, Jian Zhou, Weiping Jia
No abstract text is available yet for this article.
November 18, 2022: Diabetes Care
https://read.qxmd.com/read/36399714/medical-costs-associated-with-diabetes-complications-in-medicare-beneficiaries-aged-65-years-or-older-with-type-1-diabetes
#9
JOURNAL ARTICLE
Yu Wang, Ping Zhang, Hui Shao, Linda J Andes, Giuseppina Imperatore
OBJECTIVE: To estimate medical costs associated with 17 diabetes complications and treatment procedures among Medicare beneficiaries aged ≥65 years with type 1 diabetes. RESEARCH DESIGN AND METHODS: With use of the 2006-2017 100% Medicare claims database for beneficiaries enrolled in fee-for-service plans and Part D, we estimated the annual cost of 17 diabetes complications and treatment procedures. Type 1 diabetes and its complications and procedures were identified using ICD-9/ICD-10, procedure, and diagnosis-related group codes...
November 18, 2022: Diabetes Care
https://read.qxmd.com/read/36398782/feasibility-and-acceptability-of-using-flash-glucose-monitoring-system-sensors-to-empower-lifestyle-changes-in-people-with-prediabetes
#10
JOURNAL ARTICLE
Joyce Y Lee, Jenny T Nguyen, Jeffrey Arroyo, Tracey Tran, Dylan Hanami, José Mayorga
No abstract text is available yet for this article.
November 18, 2022: Diabetes Care
https://read.qxmd.com/read/36383734/questionnaire-based-polyexposure-assessment-outperforms-polygenic-scores-for-classification-of-type-2-diabetes-in-a-multiancestry-cohort
#11
JOURNAL ARTICLE
Farida S Akhtari, Dillon Lloyd, Adam Burkholder, Xiaoran Tong, John S House, Eunice Y Lee, John Buse, Shepherd H Schurman, David C Fargo, Charles P Schmitt, Janet Hall, Alison A Motsinger-Reif
OBJECTIVE: Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limiting the applicability of results. We conducted an exposome-wide association study in the multiancestry Personalized Environment and Genes Study to assess the effects of environmental factors on type 2 diabetes. RESEARCH DESIGN AND METHODS: Using logistic regression for single-exposure analysis, we identified exposures associated with type 2 diabetes, adjusting for age, BMI, household income, and self-reported sex and race...
November 16, 2022: Diabetes Care
https://read.qxmd.com/read/36383487/cost-effectiveness-of-a-collaborative-care-model-among-patients-with-type-2-diabetes-and-depression-in-india
#12
JOURNAL ARTICLE
Karl M F Emmert-Fees, Michael Laxy, Shivani A Patel, Kavita Singh, Subramani Poongothai, Viswanathan Mohan, Lydia Chwastiak, K M Venkat Narayan, Rajesh Sagar, Aravind R Sosale, Ranjit Mohan Anjana, Gumpeny R Sridhar, Nikhil Tandon, Mohammed K Ali
OBJECTIVE: To assess the cost-effectiveness of collaborative versus usual care in adults with poorly controlled type 2 diabetes and depression in India. RESEARCH DESIGN AND METHODS: We performed a within-trial cost-effectiveness analysis of a 24-month parallel, open-label, pragmatic randomized clinical trial at four urban clinics in India from multipayer and societal perspectives. The trial randomly assigned 404 patients with poorly controlled type 2 diabetes (HbA1c ≥8...
November 16, 2022: Diabetes Care
https://read.qxmd.com/read/36383481/deficits-and-disparities-in-early-uptake-of-glucagon-like-peptide-1-receptor-agonists-and-sglt2i-among-medicare-insured-adults-following-a-new-diagnosis-of-cardiovascular-disease-or-heart-failure
#13
JOURNAL ARTICLE
Sara J Cromer, Julie C Lauffenburger, Raisa Levin, Elisabetta Patorno
OBJECTIVE: To examine the association of race/ethnicity and socioeconomic deprivation with initiation of guideline-recommended diabetes medications with cardiovascular benefit (glucagon-like peptide 1 receptor agonists [GLP1-RA] and sodium-glucose cotransporter 2 inhibitors [SGLT2i]) among older adults with type 2 diabetes (T2D) and either incident atherosclerotic cardiovascular disease (ASCVD) or congestive heart failure (CHF). RESEARCH DESIGN AND METHODS: Using Medicare data (2016-2019), we identified 4,057,725 individuals age >65 years with T2D and either incident ASCVD or CHF...
November 16, 2022: Diabetes Care
https://read.qxmd.com/read/36383480/sleep-duration-and-risks-of-incident-cardiovascular-disease-and-mortality-among-people-with-type-2-diabetes
#14
JOURNAL ARTICLE
Han Han, Ying Wang, Tongtong Li, Chengwu Feng, Catherine Kaliszewski, Yang Su, Yinfan Wu, Jian Zhou, Liang Wang, Geng Zong
OBJECTIVE: People with type 2 diabetes may have insufficient or prolonged sleep that could accelerate cardiovascular disease (CVD) onset, but existing evidence from prospective studies has been limited. We examined the association of sleep duration with CVD incidence and mortality in this high-risk population. RESEARCH DESIGN AND METHODS: This prospective study included 18,876 participants with type 2 diabetes in the UK Biobank who were free of CVD and cancer at baseline...
November 16, 2022: Diabetes Care
https://read.qxmd.com/read/36383478/long-term-exposure-to-ambient-pm2-5-and-its-components-associated-with-diabetes-evidence-from-a-large-population-based-cohort-from-china
#15
JOURNAL ARTICLE
Sicheng Li, Bing Guo, Ye Jiang, Xing Wang, Lin Chen, Xue Wang, Ting Chen, La Yang, Yangzong Silang, Feng Hong, Jianzhong Yin, Hualiang Lin, Xing Zhao
OBJECTIVE: Association between particulate matter with aerodynamic diameters ≤2.5 μm (PM2.5) components and diabetes remains unclear. We therefore aimed to investigate the associations of long-term exposure to PM2.5 components with diabetes. RESEARCH DESIGN AND METHODS: This study included 69,210 adults with no history of diabetes from a large-scale epidemiologic survey in Southwest China from 2018 to 2019. The annual average concentrations of PM2.5 and its components were estimated using satellite remote sensing and chemical transport modeling...
November 16, 2022: Diabetes Care
https://read.qxmd.com/read/36382801/development-of-a-clinical-prediction-model-for-diabetes-in-chronic-pancreatitis-the-predict3c-study
#16
JOURNAL ARTICLE
Christie Jeon, Phil A Hart, Liang Li, Yunlong Yang, Eleanor Chang, Melena D Bellin, William E Fisher, Evan L Fogel, Christopher E Forsmark, Walter G Park, Stephen K Van Den Eeden, Santhi Swaroop Vege, Jose Serrano, David C Whitcomb, Dana K Andersen, Darwin L Conwell, Dhiraj Yadav, Mark O Goodarzi
OBJECTIVE: Diabetes that arises from chronic pancreatitis (CP) is associated with increased morbidity and mortality. Methods to predict which patients with CP are at greatest risk for diabetes are urgently needed. We aimed to examine independent risk factors for diabetes in a large cohort of patients with CP. RESEARCH DESIGN AND METHODS: This cross-sectional study comprised 645 individuals with CP enrolled in the PROCEED study, of whom 276 had diabetes. We conducted univariable and multivariable regression analyses of potential risk factors for diabetes...
November 16, 2022: Diabetes Care
https://read.qxmd.com/read/36378879/trajectories-of-cognition-and-daily-functioning-before-and-after-incident-diabetes
#17
JOURNAL ARTICLE
Xiaoli Ji, Hui Gao, Daoyuan Sun, Jianlin Zhuang, Yuan Fang, Kan Wang, Fariba Ahmadizar
OBJECTIVE: The temporal pattern of cognitive and functional change before and after incident diabetes remains unknown. RESEARCH DESIGN AND METHODS: Data from wave 2 to wave 9 (2004-2018) of the English Longitudinal Study of Ageing were used. Global cognition (assessed by orientation, memory, and executive function) and daily functioning (calculated as the sum of impaired basic and instrumental activities of daily living) were measured in each wave. Incident diabetes was defined as glycated hemoglobin A1c ≥6...
November 15, 2022: Diabetes Care
https://read.qxmd.com/read/36378855/racial-disparities-in-access-and-use-of-diabetes-technology-among-adult-patients-with-type-1-diabetes-in-a-u-s-academic-medical-center
#18
JOURNAL ARTICLE
Sarah Kanbour, Marissa Jones, Mohammed S Abusamaan, Caitlin Nass, Estelle Everett, Risa M Wolf, Aniket Sidhaye, Nestoras Mathioudakis
OBJECTIVE: Recent studies highlight racial disparities in insulin pump (PUMP) and continuous glucose monitor (CGM) use in children and adolescents with type 1 diabetes (T1D). This study explored racial disparities in diabetes technology among adult patients with T1D. RESEARCH DESIGN AND METHODS: This was a retrospective clinic-based cohort study of adult patients with T1D seen consecutively from April 2013 to January 2020. Race was categorized into non-Black (reference group) and Black...
November 15, 2022: Diabetes Care
https://read.qxmd.com/read/36378550/the-risk-of-severe-hypoglycemia-and-mortality-in-patients-with-type-2-diabetes-and-discharged-with-acute-liver-injury
#19
JOURNAL ARTICLE
Fu-Shun Yen, Ming-Chih Hou, Chun-Wei Pan, Jia-Sin Liu, Chih-Cheng Hsu, Chii-Min Hwu
OBJECTIVE: To compare the risks of severe hypoglycemia and mortality between patients with type 2 diabetes (T2D) and discharged with and without acute liver injury. RESEARCH DESIGN AND METHODS: From 1 January 2000 to 31 December 2010, we identified patients with T2D and hospitalization for acute liver injury and hospitalization for other causes from the National Health Insurance Research Database of Taiwan. Multivariable-adjusted Cox proportional hazards models were used to compare the risks of severe hypoglycemia and mortality between the study and control groups...
November 15, 2022: Diabetes Care
https://read.qxmd.com/read/36375126/patient-reported-outcomes-of-covid-19-vaccine-breakthrough-infection-associated-changes-in-glucose-control-in-subjects-with-type-1-diabetes-pro-vacs-2-study
#20
JOURNAL ARTICLE
Ilaria Dicembrini, Daniele Scoccimarro, Gloria Giovanna Del Vescovo, Christian Marinelli, Elena Zago, Chiara Delli Poggi, Laura Pala, Edoardo Mannucci
No abstract text is available yet for this article.
November 14, 2022: Diabetes Care
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