Katherine Samaras, Steve Makkar, John D Crawford, Nicole A Kochan, Wei Wen, Brian Draper, Julian N Trollor, Henry Brodaty, Perminder S Sachdev
OBJECTIVE: Type 2 diabetes (diabetes) is characterized by accelerated cognitive decline and higher dementia risk. Controversy exists regarding the impact of metformin, which is associated with both increased and decreased dementia rates. The objective of this study was to determine the association of metformin use with incident dementia and cognitive decline over 6 years in diabetes compared with those not receiving metformin and those without diabetes. RESEARCH DESIGN AND METHODS: Prospective observational study of N = 1,037 community-dwelling older participants without dementia aged 70-90 years at baseline (the Sydney Memory and Ageing Study)...
September 23, 2020: Diabetes Care
Simona Ghetti, Nathan Kuppermann, Arleta Rewers, Sage R Myers, Jeff E Schunk, Michael J Stoner, Aris Garro, Kimberly S Quayle, Kathleen M Brown, Jennifer L Trainor, Leah Tzimenatos, Andrew D DePiero, Julie K McManemy, Lise E Nigrovic, Maria Y Kwok, Clinton S Perry, Cody S Olsen, T Charles Casper, Nicole S Glaser
OBJECTIVE: This study assessed whether a single diabetic ketoacidosis (DKA) episode is associated with cognitive declines in children with newly diagnosed type 1 diabetes and whether the same is true in children who had previously been diagnosed after accounting for variations in glycemic control and other relevant factors. RESEARCH DESIGN AND METHODS: We prospectively enrolled 758 children, 6-18 years old, who presented with DKA in a randomized multisite clinical trial evaluating intravenous fluid protocols for DKA treatment...
September 22, 2020: Diabetes Care
Emily J Meyer, Edward Mignone, Anthony Hade, Venkatesan Thiruvenkatarajan, Robert V Bryant, David Jesudason
No abstract text is available yet for this article.
September 17, 2020: Diabetes Care
Pavithra Vijayakumar, Shuling Liu, Rozalina G McCoy, Andrew J Karter, Kasia J Lipska
No abstract text is available yet for this article.
September 17, 2020: Diabetes Care
Yan Xie, Benjamin Bowe, Andrew K Gibson, Janet B McGill, Geetha Maddukuri, Yan Yan, Ziyad Al-Aly
OBJECTIVE: To examine the comparative effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT2is), glucagon-like peptide 1 receptor agonists (GLP-1), dipeptidyl peptidase 4 inhibitors (DPP-4), and sulfonylureas on risk of kidney outcomes among people with type 2 diabetes. RESEARCH DESIGN AND METHODS: U.S. veterans initiated on SGLT2is ( n = 18,544), GLP-1 ( n = 23,711), DPP-4 ( n = 39,399), or sulfonylureas ( n = 134,904) were followed for up to 3 years to evaluate the risk of the composite outcome of estimated glomerular filtration rate (eGFR) decline >50%, end-stage kidney disease (ESKD), or all-cause mortality...
September 16, 2020: Diabetes Care
Ananta Addala, Marie Auzanneau, Kellee Miller, Werner Maier, Nicole Foster, Thomas Kapellen, Ashby Walker, Joachim Rosenbauer, David M Maahs, Reinhard W Holl
OBJECTIVE: As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A1c (HbA1c ). We hypothesized that an increasing gap in diabetes technology use by socioeconomic status (SES) would be associated with increased HbA1c disparities. RESEARCH DESIGN AND METHODS: Participants aged <18 years with diabetes duration ≥1 year in the Type 1 Diabetes Exchange (T1DX, U.S., n = 16,457) and Diabetes Prospective Follow-up (DPV, Germany, n = 39,836) registries were categorized into lowest (Q1) to highest (Q5) SES quintiles...
September 16, 2020: Diabetes Care
Anne L Peters, Darren K McGuire, Thomas Danne, Jake A Kushner, Helena W Rodbard, Ketan Dhatariya, Sangeeta Sawhney, Phillip Banks, Wenjun Jiang, Michael J Davies, Pablo Lapuerta
OBJECTIVE: To evaluate the incidence and risk factors for diabetic ketoacidosis (DKA) and related adverse events (AEs) in adults with type 1 diabetes treated with sotagliflozin adjunctive to insulin. RESEARCH DESIGN AND METHODS: Data from two identically designed, 52-week, randomized studies were pooled and analyzed for DKA, changes in β-hydroxybutyrate (BHB), and percentage of patients with BHB >0.6 and >1.5 mmol/L. The patients were administered placebo, sotagliflozin 200 mg, or sotagliflozin 400 mg once daily...
September 14, 2020: Diabetes Care
Ying Xie, Jannah Baker, Tamara Young, Min Jun, Louisa Sukkar, Anna Campain, Amy Kang, Alan Cass, Ji Hu, David Peiris, Carol Pollock, Germaine Wong, Sophia Zoungas, Kris Rogers, Meg Jardine, Carinna Hockham
No abstract text is available yet for this article.
September 14, 2020: Diabetes Care
Yan Xie, Benjamin Bowe, Andrew K Gibson, Janet B McGill, Yan Yan, Geetha Maddukuri, Ziyad Al-Aly
OBJECTIVE: To examine the comparative effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) empagliflozin and other non-SGLT2i antihyperglycemics on the risk of major adverse kidney events (MAKE) of estimated glomerular filtration rate (eGFR) decline >50%, end-stage kidney disease, or all-cause mortality. RESEARCH DESIGN AND METHODS: Cohort study of 379,033 new users of empagliflozin or other non-SGLT2i antihyperglycemics. Predefined variables and covariates identified by a high-dimensional variable selection algorithm were used to build propensity scores...
September 10, 2020: Diabetes Care
Leah M Wilson, Peter G Jacobs, Katrina L Ramsey, Navid Resalat, Ravi Reddy, Deborah Branigan, Joseph Leitschuh, Virginia Gabo, Florian Guillot, Brian Senf, Joseph El Youssef, Isabelle Isa Kristin Steineck, Nichole S Tyler, Jessica R Castle
OBJECTIVE: To assess the efficacy and feasibility of a dual-hormone (DH) closed-loop system with insulin and a novel liquid stable glucagon formulation compared with an insulin-only closed-loop system and a predictive low glucose suspend (PLGS) system. RESEARCH DESIGN AND METHODS: In a 76-h, randomized, crossover, outpatient study, 23 participants with type 1 diabetes used three modes of the Oregon Artificial Pancreas system: 1 ) dual-hormone (DH) closed-loop control, 2 ) insulin-only single-hormone (SH) closed-loop control, and 3 ) PLGS system...
September 9, 2020: Diabetes Care
Heba M Ismail, Mario A Cleves, Ping Xu, Ingrid M Libman, Dorothy J Becker, Jennifer B Marks, Jay S Skyler, Jerry P Palmer, Jay M Sosenko
OBJECTIVE: Glucose response curves (GRCs) during oral glucose tolerance tests (OGTTs) are predictive of type 1 diabetes. We performed a longitudinal analysis in pancreatic autoantibody-positive individuals to assess 1 ) characteristic GRC changes during progression to type 1 diabetes and 2 ) GRC changes in relation to β-cell function changes and to combined glucose and C-peptide response curve (GCRC) changes. RESEARCH DESIGN AND METHODS: Among antibody-positive individuals with serial OGTTs in the TrialNet Pathway to Prevention study, GRC changes from first to last OGTTs were compared between progressors ( n = 298) to type 1 diabetes and nonprogressors ( n = 2,216)...
September 8, 2020: Diabetes Care
Daniel T Dibaba, Karen C Johnson, Anna M Kucharska-Newton, Katie Meyer, Steven H Zeisel, Aurelian Bidulescu
OBJECTIVE: To examine the association between dietary intake of choline and betaine with the risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: Among 13,440 Atherosclerosis Risk in Communities (ARIC) study participants, the prospective longitudinal association between dietary choline and betaine intake and the risk of type 2 diabetes was assessed using interval-censored Cox proportional hazards and logistic regression models adjusted for baseline potential confounding variables...
September 8, 2020: Diabetes Care
Peter R Thingholm, Amanda Gaulke, Tine M Eriksen, Jannet Svensson, Niels Skipper
OBJECTIVE: To investigate school absenteeism before the clinical diagnosis of type 1 diabetes in children who develop the disease. RESEARCH DESIGN AND METHODS: This population-based, retrospective case-control study involved all Danish children who developed type 1 diabetes and attended public schools ( n = 1,338) from 2010 to 2017. Those children were matched at a 1-to-5 ratio, on the basis of sex and date of birth, to children without diabetes ( n = 6,690). Case and control absenteeism were compared monthly, starting with 12 months prior to the type 1 diabetes diagnosis through 12 months after diagnosis...
September 8, 2020: Diabetes Care
Marcel H A Muskiet, Lennart Tonneijck, Mark M Smits, Mark H H Kramer, D Margriet Ouwens, Bolette Hartmann, Jens J Holst, Daan J Touw, A H Jan Danser, Jaap A Joles, Daniël H van Raalte
OBJECTIVE: To compare effects of the dipeptidyl peptidase 4 (DPP-4) inhibitor linagliptin with those of a sulfonylurea on renal physiology in metformin-treated patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: In this double-blind randomized trial, 46 overweight T2DM patients without renal impairment received once-daily linagliptin (5 mg) or glimepiride (1 mg) for 8 weeks. Fasting glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were determined by inulin and para-aminohippuric acid clearances...
September 8, 2020: Diabetes Care
Qian Xiao, Jingyi Qian, Daniel S Evans, Susan Redline, Nancy E Lane, Sonia Ancoli-Israel, Frank A J L Scheer, Katie Stone
OBJECTIVE: Disruption of rest-activity rhythms is cross-sectionally associated with metabolic disorders, including type 2 diabetes, yet it remains unclear whether it predicts impaired glucose metabolism and homeostasis. The aim of this study is to examine the cross-sectional and prospective associations between rest-activity rhythm characteristics and glycemic measures in a cohort of older men. RESEARCH DESIGN AND METHODS: Baseline rest-activity rhythms were derived from actigraphy with use of extended cosine model analysis...
September 4, 2020: Diabetes Care
Andrew Sumarsono, Leo F Buckley, Sara R Machado, Rishi K Wadhera, Haider J Warraich, Rishi J Desai, Brendan M Everett, Darren K McGuire, Gregg C Fonarow, Javed Butler, Ambarish Pandey, Muthiah Vaduganathan
OBJECTIVE: Certain antihyperglycemic therapies modify cardiovascular and kidney outcomes among patients with type 2 diabetes, but early uptake in practice appears restricted to particular demographics. We examine the association of Medicaid expansion with use of and expenditures related to antihyperglycemic therapies among Medicaid beneficiaries. RESEARCH DESIGN AND METHODS: We employed a difference-in-difference design to analyze the association of Medicaid expansion on prescription of noninsulin antihyperglycemic therapies...
September 4, 2020: Diabetes Care
Katsuhito Ihara, Jan Skupien, Hiroki Kobayashi, Zaipul I Md Dom, Jonathan M Wilson, Kristina O'Neil, Hannah S Badger, Lenden M Bowsman, Eiichiro Satake, Matthew D Breyer, Kevin L Duffin, Andrzej S Krolewski
OBJECTIVE: The role of fibrosis in early progressive renal decline in type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and matrix metalloproteinase 7 (MMP-7; Matrilysin) are postulated to be biomarkers of renal fibrosis. This study examined an association of circulating levels of these proteins with early progressive renal decline. RESEARCH DESIGN AND METHODS: Individuals with type 2 diabetes enrolled in the Joslin Kidney Study with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1...
September 4, 2020: Diabetes Care
Yuxin Fan, Yun Shen, Jian Zhou, Lizheng Shi, Elizabeth Nauman, Peter T Katzmarzyk, Eboni G Price-Haywood, Ronald Horswell, San Chu, Alessandra N Bazzano, Gang Hu
No abstract text is available yet for this article.
September 4, 2020: Diabetes Care
Alessia Pepe, Laura Pistoia, Maria Rita Gamberini, Liana Cuccia, Angelo Peluso, Giuseppe Messina, Anna Spasiano, Massimo Allò, Maria Grazia Bisconte, Maria Caterina Putti, Tommaso Casini, Nicola Dello Iacono, Mauro Celli, Angelantonio Vitucci, Pietro Giuliano, Giuseppe Peritore, Stefania Renne, Riccardo Righi, Vincenzo Positano, Vincenzo De Sanctis, Antonella Meloni
OBJECTIVE: We systematically explored the link of pancreatic iron with glucose metabolism and with cardiac complications in a cohort of 1,079 patients with thalassemia major (TM) enrolled in the Extension-Myocardial Iron Overload in Thalassemia (E-MIOT) project. RESEARCH DESIGN AND METHODS: MRI was used to quantify iron overload (T2* technique) and cardiac function (cine images) and to detect macroscopic myocardial fibrosis (late gadolinium enhancement technique)...
September 4, 2020: Diabetes Care
Ajenthen G Ranjan, Signe V Rosenlund, Tine W Hansen, Peter Rossing, Steen Andersen, Kirsten Nørgaard
OBJECTIVE: To investigate the association between treatment-induced change in continuous glucose monitoring (CGM) time in range (TIR) and albuminuria in persons with type 1 diabetes (T1D) treated with sensor-augmented insulin pumps (SAP). RESEARCH DESIGN AND METHODS: Twenty-six out of 55 participants with albuminuria and multiple daily injection therapy (25% females; 51 [46-63] years of age; glycated hemoglobin A1c (HbA1c ) 75 [68-88] mmol/mol [9.0% (8.4-10.4%)]; and urinary albumin-to-creatinine ratio (UACR) 89 [37-250] mg/g) were in a randomized controlled trial assigned to SAP therapy for 1 year...
September 4, 2020: Diabetes Care
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