journal
MENU ▼
Read by QxMD icon Read
search

Diabetes Care

journal
https://read.qxmd.com/read/30885955/the-sglt2-inhibitor-dapagliflozin-reduces-liver-fat-but-does-not-affect-tissue-insulin-sensitivity-a-randomized-double-blind-placebo-controlled-study-with-8-week-treatment-in-type-2-diabetes-patients
#1
Aino Latva-Rasku, Miikka-Juhani Honka, Joel Kullberg, Nina Mononen, Terho Lehtimäki, Juha Saltevo, Anna K Kirjavainen, Virva Saunavaara, Patricia Iozzo, Lars Johansson, Jan Oscarsson, Jarna C Hannukainen, Pirjo Nuutila
OBJECTIVE: The aim of this study was to investigate tissue-specific effects of dapagliflozin on insulin sensitivity and liver and body fat in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: This randomized, double-blind, parallel group, placebo-controlled study recruited 32 patients with type 2 diabetes. Enrolled patients were to have HbA1c 6.5-10.5% (48-91 mmol/mol) and ≥3 months of stable treatment with metformin, dipeptidyl peptidase 4 inhibitor, or their combination...
March 18, 2019: Diabetes Care
https://read.qxmd.com/read/30885954/soluble-urokinase-plasminogen-activator-receptor-predicts-cardiovascular-events-kidney-function-decline-and-mortality-in-patients-with-type-1-diabetes
#2
Viktor Rotbain Curovic, Simone Theilade, Signe A Winther, Nete Tofte, Jesper Eugen-Olsen, Frederik Persson, Tine W Hansen, Jørgen Jeppesen, Peter Rossing
OBJECTIVE: Soluble urokinase plasminogen activator receptor (suPAR) is an important inflammatory biomarker implicated in endothelial and podocyte dysfunction. However, suPAR's predictive qualities for complications in type 1 diabetes have yet to be determined. We investigated the prognostic value of suPAR for the development of cardiovascular events, decline in renal function, and mortality in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: We included 667 patients with type 1 diabetes with various degrees of albuminuria in a prospective study...
March 18, 2019: Diabetes Care
https://read.qxmd.com/read/30885953/sex-differences-in-treatment-with-ace-inhibitors-and-angiotensin-receptor-blockers-in-type-1-diabetes-patients
#3
LETTER
Anna Möllsten, Cecilia Toppe, Katarina Eeg-Olofsson, Torbjörn Lind
No abstract text is available yet for this article.
March 18, 2019: Diabetes Care
https://read.qxmd.com/read/30885952/biochemical-urine-testing-of-adherence-to-cardiovascular-medications-reveals-high-rates-of-nonadherence-in-people-attending-their-annual-review-for-type-2-diabetes
#4
Prashanth Patel, Pankaj Gupta, Angela Burns, Ali A Mohamed, Richard Cole, Dan Lane, Samuel Seidu, Kamlesh Khunti
OBJECTIVE: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a new method to objectively and robustly detect nonadherence. We applied this technique to study nonadherence to cardiovascular medications in people with type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS: Routine urine samples, received at the time of the annual diabetes review from 228 people with T2DM in primary care, were assessed for adherence by LC-MS/MS. RESULTS: A total of 28...
March 18, 2019: Diabetes Care
https://read.qxmd.com/read/30885951/variation-in-the-plasma-membrane-monoamine-transporter-pmat-encoded-in-slc29a4-and-organic-cation-transporter-1-oct1-encoded-in-slc22a1-and-gastrointestinal-intolerance-to-metformin-in-type-2-diabetes-an-imi-direct-study
#5
Adem Y Dawed, Kaixin Zhou, Nienke van Leeuwen, Anubha Mahajan, Neil Robertson, Robert Koivula, Petra J M Elders, Simone P Rauh, Angus G Jones, Reinhard W Holl, Julia C Stingl, Paul W Franks, Mark I McCarthy, Leen 't Hart, Ewan R Pearson
OBJECTIVE: Gastrointestinal adverse effects occur in 20-30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5-10% of the cases. Gastrointestinal intolerance may reflect localized high concentrations of metformin in the gut. We hypothesized that reduced transport of metformin via the plasma membrane monoamine transporter (PMAT) and organic cation transporter 1 (OCT1) could increase the risk of severe gastrointestinal adverse effects. RESEARCH DESIGN AND METHODS: The study included 286 severe metformin-intolerant and 1,128 metformin-tolerant individuals from the IMI DIRECT (Innovative Medicines Initiative: DIabetes REsearCh on patient straTification) consortium...
March 18, 2019: Diabetes Care
https://read.qxmd.com/read/30885950/uric-acid-is-an-independent-risk-factor-for-decline-in-kidney-function-cardiovascular-event-and-mortality-in-patients-with-type-1-diabetes
#6
Sascha Pilemann-Lyberg, Tine Willum Hansen, Nete Tofte, Signe Abitz Winther, Simone Theilade, Tarunveer Singh Ahluwalia, Peter Rossing
OBJECTIVE: Previous studies have provided inconclusive results on the role of uric acid (UA) in risk prediction. Here we aimed to improve the power and precision of the predictive value of UA for the risk of decline in kidney function, cardiovascular events (CVEs), and mortality in patients with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Plasma UA was measured in 670 patients with T1D and various degrees of albuminuria, ranging from normoalbuminuria to macroalbuminuria...
March 18, 2019: Diabetes Care
https://read.qxmd.com/read/30885949/erratum-genetics-coming-of-age-in-type-1-diabetes-diabetes-care-2019-42-189-191
#7
Karen Cerosaletti, Wei Hao, Carla J Greenbaum
No abstract text is available yet for this article.
March 18, 2019: Diabetes Care
https://read.qxmd.com/read/30885948/erratum-the-virtual-office-visit-for-women-with-gestational-diabetes-mellitus-diabetes-care-2017-40-e34-e35
#8
David A Sacks, Deborah Ling Grant, Mayra Macias, Xia Li, Jean M Lawrence
No abstract text is available yet for this article.
March 18, 2019: Diabetes Care
https://read.qxmd.com/read/30877090/long-term-effects-of-metformin-on-diabetes-prevention-identification-of-subgroups-that-benefited-most-in-the-diabetes-prevention-program-and-diabetes-prevention-program-outcomes-study
#9
(no author information available yet)
OBJECTIVE: We examined the effects of metformin on diabetes prevention and the subgroups that benefited most over 15 years in the Diabetes Prevention Program (DPP) and its follow-up, the Diabetes Prevention Program Outcomes Study (DPPOS). RESEARCH DESIGN AND METHODS: During the DPP (1996-2001), adults at high risk of developing diabetes were randomly assigned to masked placebo ( n = 1,082) or metformin 850 mg twice daily ( n = 1,073). Participants originally assigned to metformin continued to receive metformin, unmasked, in the DPPOS (2002-present)...
March 15, 2019: Diabetes Care
https://read.qxmd.com/read/30877089/early-detection-of-hypoglycemia-in-type-1-diabetes-using-heart-rate-variability-measured-by-a-wearable-device
#10
Marleen Olde Bekkink, Mats Koeneman, Bastiaan E de Galan, Sebastian J Bredie
OBJECTIVE: Changes in heart rate variability (HRV) occur at the initiation of hypoglycemia due to sympathetic nervous system activity. We investigated the use of HRV detection by a wearable device as an early alert for hypoglycemia. RESEARCH DESIGN AND METHODS: Proof-of-principle study including 23 patients with type 1 diabetes (14 women, mean age 42 ± 11 years). Patients wore a VitalConnect HealthPatch for 5 days. Hypoglycemia was defined as glucose ≤70 mg/dL (≤3...
March 15, 2019: Diabetes Care
https://read.qxmd.com/read/30862659/comparative-effectiveness-and-maintenance-of-diabetes-self-management-education-interventions-for-marshallese-patients-with-type-2-diabetes-a-randomized-controlled-trial
#11
Pearl A McElfish, Christopher R Long, Peter O Kohler, Karen H K Yeary, Zoran Bursac, Marie-Rachelle Narcisse, Holly C Felix, Brett Rowland, Jonell S Hudson, Peter A Goulden
OBJECTIVE: Marshallese adults experience high rates of type 2 diabetes. Previous diabetes self-management education (DSME) interventions among Marshallese were unsuccessful. This study compared the extent to which two DSME interventions improved glycemic control, measured on the basis of change in glycated hemoglobin (HbA1c ). RESEARCH DESIGN AND METHODS: A two-arm randomized controlled trial compared a standard-model DSME (standard DSME) with a culturally adapted family-model DSME (adapted DSME)...
March 12, 2019: Diabetes Care
https://read.qxmd.com/read/30862658/efficacy-and-safety-of-empagliflozin-in-renal-transplant-recipients-with-posttransplant-diabetes-mellitus
#12
Thea Anine Strøm Halden, Kine Eide Kvitne, Karsten Midtvedt, Laavanyaah Rajakumar, Ida Robertsen, Jan Brox, Jens Bollerslev, Anders Hartmann, Anders Åsberg, Trond Jenssen
OBJECTIVE: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have lately become the recommended treatment in patients with type 2 diabetes and high cardiovascular risk. Patients with posttransplant diabetes mellitus (PTDM) also have high cardiovascular risk. The aim of this study was to investigate the safety and efficacy of empagliflozin in renal transplant recipients with PTDM. RESEARCH DESIGN AND METHODS: Forty-nine renal transplant recipients were included in an investigator-initiated, single-center, prospective, double-blind study and randomized to receive either 10 mg empagliflozin or placebo once daily for 24 weeks...
March 12, 2019: Diabetes Care
https://read.qxmd.com/read/30862657/risk-of-incident-obstructive-sleep-apnea-among-patients-with-type-2-diabetes
#13
Anuradhaa Subramanian, Nicola J Adderley, Alexander Tracy, Tom Taverner, Wasim Hanif, Konstantinos A Toulis, G Neil Thomas, Abd A Tahrani, Krishnarajah Nirantharakumar
OBJECTIVE: This study compared the incidence of obstructive sleep apnea (OSA) in patients with and without type 2 diabetes and investigated risk factors for OSA in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A retrospective cohort study was performed to compare OSA incidence between adult patients with and without type 2 diabetes matched for age, sex, and BMI. Patients with a prevalent OSA diagnosis were excluded. The study cohort was derived from The Health Improvement Network (THIN), a U...
March 12, 2019: Diabetes Care
https://read.qxmd.com/read/30862656/disordered-eating-behaviors-in-youth-and-young-adults-with-type-1-or-type-2-diabetes-receiving-insulin-therapy-the-search-for-diabetes-in-youth-study
#14
Angel S Y Nip, Beth A Reboussin, Dana Dabelea, Anna Bellatorre, Elizabeth J Mayer-Davis, Anna R Kahkoska, Jean M Lawrence, Claire M Peterson, Lawrence Dolan, Catherine Pihoker
OBJECTIVE: This study examines the prevalence of disordered eating behaviors (DEB) and its associations with glycemic control, insulin sensitivity (IS), and psychosocial functioning in a large, diverse cohort of youth and young adults with type 1 or type 2 diabetes. RESEARCH DESIGN AND METHODS: In the SEARCH for Diabetes in Youth study, 2,156 youth and young adults with type 1 diabetes (mean ± SD age 17.7 ± 4.3 years; 50.0% female) and 149 youth and young adults with type 2 diabetes (age 21...
March 12, 2019: Diabetes Care
https://read.qxmd.com/read/30862655/intractable-coronary-artery-disease-in-a-patient-with-type-2-diabetes-presenting-with-triglyceride-deposit-cardiomyovasculopathy
#15
Junji Kozawa, Masahiro Higashi, Iichiro Shimomura, Ken-Ichi Hirano
No abstract text is available yet for this article.
March 12, 2019: Diabetes Care
https://read.qxmd.com/read/30862654/underuse-of-medications-and-lifestyle-counseling-to-prevent-cardiovascular-disease-in-patients-with-diabetes
#16
LETTER
Jonathan D Newman, Jeffrey S Berger, Joseph A Ladapo
No abstract text is available yet for this article.
March 12, 2019: Diabetes Care
https://read.qxmd.com/read/30862653/post-aca-racial-disparity-of-eye-examinations-among-the-u-s-noninstitutionalized-population-with-diabetes-2014-2015
#17
LETTER
Alisha M Monnette, M Kristina Wharton, Yingnan Zhao, Vivian A Fonseca, Lizheng Shi
No abstract text is available yet for this article.
March 12, 2019: Diabetes Care
https://read.qxmd.com/read/30862652/dysglycemia-and-the-density-of-the-coronary-vasa-vasorum
#18
Hertzel C Gerstein, Vidhya Nair, Ruchi Chaube, Heidi Stoute, Geoff Werstuck
OBJECTIVE: This study was conducted to determine the relationship between dysglycemia and the coronary artery vasa vasorum density. RESEARCH DESIGN AND METHODS: The left anterior descending coronary artery was removed from 57 deceased individuals during autopsy, and the capillaries in the vessel wall were identified using fluorescent immunohistochemical staining. HbA1c was determined in postmortem whole blood for each individual. The density of the vasa vasorum in the intima-media and the adventitia was manually quantified and recorded by readers unaware of the individual's other characteristics...
March 12, 2019: Diabetes Care
https://read.qxmd.com/read/30862651/testosterone-therapy-in-men-with-hypogonadism-prevents-progression-from-prediabetes-to-type-2-diabetes-eight-year-data-from-a-registry-study
#19
Aksam Yassin, Ahmad Haider, Karim S Haider, Monica Caliber, Gheorghe Doros, Farid Saad, W Timothy Garvey
OBJECTIVE: Type 2 diabetes (T2D) is a public health threat. Prediabetes represents a window of opportunity for intervention to prevent T2D. Men with T2D and prediabetes often have low testosterone. Since testosterone improves glycemic control in T2D, we investigated whether testosterone therapy (TTh) in men with hypogonadism and prediabetes prevents progression to T2D. RESEARCH DESIGN AND METHODS: Three hundred sixteen men with prediabetes (defined as HbA1c 5.7-6...
March 12, 2019: Diabetes Care
https://read.qxmd.com/read/30862650/nonadherence-to-insulin-therapy-detected-by-bluetooth-enabled-pen-cap-is-associated-with-poor-glycemic-control
#20
Medha N Munshi, Christine Slyne, Jordan M Greenberg, Tori Greaves, Ariel Lee, Sam Carl, Astrid Atakov-Castillo, Elena Toschi
OBJECTIVE: To objectively evaluate adherence to timing and dosing of insulin by using Bluetooth pen caps and examine factors related to adherence. RESEARCH DESIGN AND METHODS: Bluetooth-enabled insulin pen caps were used in younger (ages 18-35 years) and older (ages ≥65 years) adults on two or more insulin injections per day. RESULTS: We evaluated 75 participants with diabetes, 42 younger (29 ± 4 years) and 33 older (73 ± 7 years). Nonadherence was found in 24% of bolus (Apidra) doses and 36% of basal (Lantus) doses...
March 12, 2019: Diabetes Care
journal
journal
20095
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"