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Diabetes Care

Frank D Verbraak, Michael D Abramoff, Gonny C F Bausch, Caroline Klaver, Giel Nijpels, Reinier O Schlingemann, Amber A van der Heijden
OBJECTIVE: To determine the diagnostic accuracy in a real-world primary care setting of a deep learning-enhanced device for automated detection of diabetic retinopathy (DR). RESEARCH DESIGN AND METHODS: Retinal images of people with type 2 diabetes visiting a primary care screening program were graded by a hybrid deep learning-enhanced device (IDx-DR-EU-2.1; IDx, Amsterdam, the Netherlands), and its classification of retinopathy (vision-threatening [vt]DR, more than mild [mtm]DR, and mild or more [mom]DR) was compared with a reference standard...
February 14, 2019: Diabetes Care
Erin S Morgan, Li-Jung Tai, Nguyen C Pham, Julia K Overman, Lynnetta M Watts, Anne Smith, Shiangtung W Jung, Martin Gajdošík, Martin Krššák, Michael Krebs, Richard S Geary, Brenda F Baker, Sanjay Bhanot
OBJECTIVE: To evaluate the safety and efficacy of IONIS-GCGRRx , a 2'- O -methoxyethyl antisense oligonucleotide targeting the glucagon receptor (GCGR), and the underlying mechanism of liver transaminase increases in patients with type 2 diabetes on stable metformin therapy. RESEARCH DESIGN AND METHODS: In three phase 2, randomized, double-blind studies, patients with type 2 diabetes on metformin received weekly subcutaneous injections of IONIS-GCGRRx (50-200 mg) or placebo for 13 or 26 weeks...
February 14, 2019: Diabetes Care
Maarten Coemans, Elisabet Van Loon, Evelyne Lerut, Pieter Gillard, Ben Sprangers, Aleksandar Senev, Marie-Paule Emonds, Jan Van Keer, Jasper Callemeyn, Liesbeth Daniëls, Jeroen Sichien, Geert Verbeke, Dirk Kuypers, Chantal Mathieu, Maarten Naesens
OBJECTIVE: The kinetics and risk factors of diabetic nephropathy after kidney transplantation remain unclear. This study investigated the posttransplant occurrence of diabetic nephropathy and the contribution of posttransplant glycemic control. RESEARCH DESIGN AND METHODS: We performed a single-center prospective cohort study of 953 renal allograft recipients and 3,458 protocol-specified renal allograft biopsy specimens up to 5 years after transplantation. The effects of pretransplant diabetes and glycemic control (glycated hemoglobin levels) on the posttransplant histology were studied...
February 14, 2019: Diabetes Care
Eva Tseng, Arlene T Dalcin, Gerald J Jerome, Joseph V Gennusa, Stacy Goldsholl, Courtney Cook, Lawrence J Appel, Nisa M Maruthur, Gail L Daumit, Nae-Yuh Wang
OBJECTIVE: Given the high prevalence of obesity and diabetes in patients with serious mental illness (SMI) and the lack of evidence on the effects of weight loss programs in SMI patients with diabetes, we evaluated the effectiveness of a behavioral weight loss intervention among SMI participants with and without diabetes. RESEARCH DESIGN AND METHODS: Using data from ACHIEVE, a randomized controlled trial to evaluate the effects of a behavioral weight loss intervention among overweight/obese people with SMI, we assessed and compared weight change from baseline to 18 months in participants with and without diabetes using a longitudinal mixed-effects model...
February 14, 2019: Diabetes Care
Antonio Ceriello, Maria Chiara Rossi, Salvatore De Cosmo, Giuseppe Lucisano, Roberto Pontremoli, Paola Fioretto, Carlo Giorda, Antonio Pacilli, Francesca Viazzi, Giuseppina Russo, Antonio Nicolucci
OBJECTIVE: An association between variability in clinical parameters (HbA1c , blood pressure, cholesterol, and uric acid) and risk of complications in type 2 diabetes has been reported. In this analysis, we investigated to what extent such variability is associated with overall quality of care. RESEARCH DESIGN AND METHODS: The quality of care summary score (Q-score) represents a validated, overall quality of care indicator ranging between 0 and 40; the higher the score, the better the quality of care provided by the diabetes center...
February 14, 2019: Diabetes Care
Petros Yiannoullou, Angela Summers, Shu C Goh, Catherine Fullwood, Hussein Khambalia, Zia Moinuddin, Iestyn M Shapey, Josephine Naish, Christopher Miller, Titus Augustine, Martin K Rutter, David van Dellen
OBJECTIVE: People with type 1 diabetes and kidney failure have an increased risk for major adverse cardiovascular events (MACE). Simultaneous pancreas and kidney transplantation (SPKT) improves survival, but the long-term risk for MACE is uncertain. RESEARCH DESIGN AND METHODS: We assessed the frequency and risk factors for MACE (defined as fatal cardiovascular disease and nonfatal myocardial infarction or stroke) and related nonfatal MACE to allograft failure in SPKT recipients with type 1 diabetes who underwent transplantation between 2001 and 2015 in the U...
February 14, 2019: Diabetes Care
Ulla M Hansen, Timothy Skinner, Kasper Olesen, Ingrid Willaing
OBJECTIVE: The aim was to explore relationships between work-related factors, work-related diabetes distress (WRDD), diabetes distress (measured by Problem Areas in Diabetes [PAID]-5 scale), intentional hyperglycemia at work (IHW), and glycemic control. RESEARCH DESIGN AND METHODS: A cross-sectional survey was conducted with 1,030 working adults with type 1 diabetes and linked with electronic health record data from a specialist diabetes clinic in Denmark. With use of structural equation modeling, two alternative models were compared, based on fit indices, statistical significance, and theoretical meaningfulness...
February 14, 2019: Diabetes Care
Xiang Zhang, Richard L Young, Michelle Bound, Sanyuan Hu, Karen L Jones, Michael Horowitz, Christopher K Rayner, Tongzhi Wu
OBJECTIVE: Cells releasing glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are distributed predominately in the proximal and distal gut, respectively. Hence, the region of gut exposed to nutrients may influence GIP and GLP-1 secretion and impact on the incretin effect and gastrointestinal-mediated glucose disposal (GIGD). We evaluated glycemic and incretin responses to glucose administered into the proximal or distal small intestine and quantified the corresponding incretin effect and GIGD in health and type 2 diabetes mellitus (T2DM)...
February 14, 2019: Diabetes Care
Graham R Law, Alia Alnaji, Lina Alrefaii, Del Endersby, Sarah J Cartland, Stephen G Gilbey, Paul E Jennings, Helen R Murphy, Eleanor M Scott
OBJECTIVE: Continuous glucose monitoring (CGM) provides far greater detail about fetal exposure to maternal glucose across the 24-h day. Our aim was to examine the role of temporal glucose variation on the development of large for gestational age (LGA) infants in women with treated gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: We performed a prospective observational study of 162 pregnant women with GDM in specialist multidisciplinary antenatal diabetes clinics...
February 14, 2019: Diabetes Care
Andrew J Karter, E Margaret Warton, Howard H Moffet, James D Ralston, Elbert S Huang, Donald R Miller, Kasia J Lipska
No abstract text is available yet for this article.
February 14, 2019: Diabetes Care
Masaya Sakamoto, Daisuke Matsutani, Soichiro Minato, Yuki Tsujimoto, Yosuke Kayama, Norihiko Takeda, Seiichi Ichikawa, Ryuzo Horiuchi, Kazunori Utsunomiya, Masako Nishikawa
OBJECTIVE: Precise monthly achievement rates for reaching guideline targets for HbA1c, blood pressure (BP), and lipid levels remain unknown. We evaluated achievement rates on a monthly basis in persons with type 2 diabetes mellitus (T2DM) and explored related factors. RESEARCH DESIGN AND METHODS: This retrospective study initially analyzed data on 104,601 persons with T2DM throughout Japan. Patients whose HbA1c, BP, and low-density lipoprotein (LDL)-cholesterol were measured ≥12 times during a 24-month period were included...
February 10, 2019: Diabetes Care
Thomas Danne, Satish Garg, Anne L Peters, John B Buse, Chantal Mathieu, Jeremy H Pettus, Charles M Alexander, Tadej Battelino, F Javier Ampudia-Blasco, Bruce W Bode, Bertrand Cariou, Kelly L Close, Paresh Dandona, Sanjoy Dutta, Ele Ferrannini, Spiros Fourlanos, George Grunberger, Simon R Heller, Robert R Henry, Martin J Kurian, Jake A Kushner, Tal Oron, Christopher G Parkin, Thomas R Pieber, Helena W Rodbard, Desmond Schatz, Jay S Skyler, William V Tamborlane, Koutaro Yokote, Moshe Phillip
Sodium glucose cotransporter (SGLT) inhibitors are new oral antidiabetic medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure and body weight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mild hyperglycemia, complicating the recognition/diagnosis of DKA and potentially delaying treatment...
February 6, 2019: Diabetes Care
Walid Saliba, Ofra Barnett-Griness, Naomi Gronich, Jeremy Molad, Jonathan Naftali, Gad Rennert, Eitan Auriel
OBJECTIVE: To examine the association of diabetes and glycated hemoglobin (HbA1c ) with the risk of intracerebral hemorrhage (ICH) in a large population-based cohort. RESEARCH DESIGN AND METHODS: The computerized database of the largest health care provider in Israel was used to identify adult members aged 40 years or older and alive at 1 January 2010 (297,486 with diabetes and 1,167,585 without diabetes). The cohort was followed until 31 December 2017 for incidence of ICH...
February 6, 2019: Diabetes Care
Edouard Gerbaud, Romain Darier, Michel Montaudon, Marie-Christine Beauvieux, Christine Coffin-Boutreux, Pierre Coste, Hervé Douard, Alexandre Ouattara, Bogdan Catargi
OBJECTIVE: Acute glucose fluctuations are associated with hypoglycemia and are emerging risk factors for cardiovascular outcomes. However, the relationship between glycemic variability (GV) and the occurrence of midterm major cardiovascular events (MACE) in patients with diabetes remains unclear. This study investigated the prognostic value of GV in patients with diabetes and acute coronary syndrome (ACS). RESEARCH DESIGN AND METHODS: This study included consecutive patients with diabetes and ACS between January 2015 and November 2016...
February 6, 2019: Diabetes Care
Lalantha Leelarathna, Roy W Beck, Richard M Bergenstal, Hood Thabit, Roman Hovorka
No abstract text is available yet for this article.
February 6, 2019: Diabetes Care
Joshua M Evron, William H Herman, Laura N McEwen
OBJECTIVE: Screening involves the presumptive identification of asymptomatic individuals at increased risk for unrecognized disease. We examined changes in screening practices for prediabetes and diabetes since January 2010, when HbA1c was first recommended as an option for screening and diagnosis. RESEARCH DESIGN AND METHODS: We studied members without diabetes of an HMO ≥45 years of age continuously enrolled for ≥3 years and assigned to primary care clinicians affiliated with a large academic health system...
February 6, 2019: Diabetes Care
Linda E T Vissers, Ivonne Sluijs, Yvonne T van der Schouw, Nita G Forouhi, Fumiaki Imamura, Stephen Burgess, Aurelio Barricarte, Heiner Boeing, Catalina Bonet, Maria-Dolores Chirlaque, Guy Fagherazzi, Paul W Franks, Heinz Freisling, Marc J Gunter, J Ramón Quirós, Daniel B Ibsen, Rudolf Kaaks, Timothy Key, Kay T Khaw, Tilman Kühn, Olatz Mokoroa, Peter M Nilsson, Kim Overvad, Valeria Pala, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Annemieke M W Spijkerman, Anne Tjonneland, Rosario Tumino, Miguel Rodríguez-Barranco, Olov Rolandsson, Elio Riboli, Stephen J Sharp, Claudia Langenberg, Nicholas J Wareham
OBJECTIVE: To estimate the causal association between intake of dairy products and incident type 2 diabetes. RESEARCH DESIGN AND METHODS: The analysis included 21,820 European individuals (9,686 diabetes cases) of the EPIC-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a SNP for lactase persistence (LP) which enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires...
February 6, 2019: Diabetes Care
Barbara H Braffett, Samuel Dagogo-Jack, Ionut Bebu, William I Sivitz, Mary Larkin, Orville Kolterman, John M Lachin
OBJECTIVE: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study demonstrated the beneficial effects of intensive therapy on atherosclerosis and clinical cardiovascular disease (CVD) outcomes. The current analyses evaluated the relationship between longitudinal changes in insulin dose and CVD risk factors and outcomes. RESEARCH DESIGN AND METHODS: A total of 1,441 participants were randomly assigned to intensive or conventional diabetes therapy during the DCCT...
February 6, 2019: Diabetes Care
Liliana Gutiérrez-Carrasquilla, Enric Sánchez, Ferran Barbé, Mireia Dalmases, Carolina López-Cano, Marta Hernández, Ferran Rius, Paola Carmona, Cristina Hernández, Rafael Simó, Albert Lecube
OBJECTIVE: Type 2 diabetes exerts a deleterious effect on lung function. However, it is unknown whether an improvement in glycemic control ameliorates pulmonary function. RESEARCH DESIGN AND METHODS: Prospective interventional study with 60 patients with type 2 diabetes and forced expiratory volume in 1 s (FEV1) ≤90% of predicted. Spirometric maneuvers were evaluated at baseline and after a 3-month period in which antidiabetic therapy was intensified. Those with an HbA1c reduction of ≥0...
January 31, 2019: Diabetes Care
Nadira S Kakoly, Arul Earnest, Helena J Teede, Lisa J Moran, Anju E Joham
OBJECTIVE: The nature of the independent relationship between polycystic ovary syndrome (PCOS) and type 2 diabetes remains unclear. Few studies have aimed to clarify this relationship independent of obesity in longitudinal population-based cohorts. RESEARCH DESIGN AND METHODS: We used the Australian Longitudinal Study on Women's Health (ALSWH) (2000-2015) database to estimate nationwide incidence rates and predictors of type 2 diabetes among women aged 18-42 using person-time and survival analysis...
January 31, 2019: Diabetes Care
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