journal
https://read.qxmd.com/read/34285101/glucagon-like-peptide-1-receptor-agonists-and-chronic-lower-respiratory-disease-exacerbations-among-patients-with-type-2-diabetes-diabetes-care-2021-44-1344-1352
#1
LETTER
Yasser Albogami, Kenneth Cusi, Michael J Daniels, Yu-Jung J Wei, Almut G Winterstein
No abstract text is available yet for this article.
July 20, 2021: Diabetes Care
https://read.qxmd.com/read/34285100/bone-mineral-density-and-type-1-diabetes-in-children-and-adolescents-a-meta-analysis
#2
Phoebe Loxton, Kruthika Narayan, Craig F Munns, Maria E Craig
BACKGROUND: There is substantial evidence that adults with type 1 diabetes have reduced bone mineral density (BMD); however, findings in youth are inconsistent. PURPOSE: To perform a systematic review and meta-analysis of BMD in youth with type 1 diabetes using multiple modalities: DXA, peripheral quantitative computed tomography (pQCT), and/or quantitative ultrasound (QUS). DATA SOURCES: PubMed, Embase, Scopus, and Web of Science from 1 January 1990 to 31 December 2020, limited to humans, without language restriction...
July 20, 2021: Diabetes Care
https://read.qxmd.com/read/34285099/glucagon-like-peptide-1-receptor-agonists-and-chronic-lower-respiratory-disease-exacerbations-among-patients-with-type-2-diabetes-diabetes-care-2021-44-1344-1352
#3
LETTER
Dinah Foer, Katherine N Cahill
No abstract text is available yet for this article.
July 20, 2021: Diabetes Care
https://read.qxmd.com/read/34285098/daniel-h-mintz-1930-2020-an-extraordinary-physician-scientist-and-a-pioneer-in-islet-transplantation
#4
Rodolfo Alejandro, Alessia Fornoni, Luigi Meneghini, Alberto Pugliese, Ronald B Goldberg
No abstract text is available yet for this article.
July 20, 2021: Diabetes Care
https://read.qxmd.com/read/34285097/association-of-glycemia-lipids-and-blood-pressure-with-cognitive-performance-in-people-with-type-2-diabetes-in-the-glycemia-reduction-approaches-in-diabetes-a-comparative-effectiveness-study
#5
José A Luchsinger, Naji Younes, Jennifer J Manly, Joshua Barzilay, Willy Valencia, Mary E Larkin, Corinna Falck-Ytter, Heidi Krause-Steinrauf, Rodica Pop-Busui, Hermes Florez, Elizabeth Seaquist
OBJECTIVE: Type 2 diabetes is a risk factor for cognitive impairment. We examined the relation of glycemia, lipids, blood pressure (BP), hypertension history, and statin use with cognition in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). RESEARCH DESIGN AND METHODS: Cross-sectional analyses from GRADE at baseline examined the association of glycemia (hemoglobin A1c [HbA1c ]), LDL, systolic BP (SBP) and diastolic BP (DBP), hypertension history, and statin use with cognition assessed by the Spanish English Verbal Learning Test, letter and animal fluency tests, and Digit Symbol Substitution Test (DSST)...
July 20, 2021: Diabetes Care
https://read.qxmd.com/read/34282028/continuous-glucose-monitoring-improves-glycemic-outcomes-in-children-with-type-1-diabetes-real-world-data-from-a-population-based-clinic
#6
LETTER
Elaine E Sanderson, Mary B Abraham, Grant J Smith, Jenny A Mountain, Timothy W Jones, Elizabeth A Davis
No abstract text is available yet for this article.
July 19, 2021: Diabetes Care
https://read.qxmd.com/read/34261733/trends-in-diagnosed-and-undiagnosed-diabetes-among-adults-in-the-u-s-2005-2016
#7
LETTER
Peng-Fei Xia, Xiong-Fei Pan, Yue Li, Kunquan Guo, Kun Yang, Zhou-Zheng Tu, Yan-Bo Zhang, Ting-Ting Geng, Gang Liu, An Pan
No abstract text is available yet for this article.
July 14, 2021: Diabetes Care
https://read.qxmd.com/read/34261732/primary-care-health-care-use-for-patients-with-type-2-diabetes-during-the-covid-19-pandemic
#8
LETTER
Anita D Misra-Hebert, Bo Hu, Kevin M Pantalone, Elizabeth R Pfoh
No abstract text is available yet for this article.
July 14, 2021: Diabetes Care
https://read.qxmd.com/read/34257098/genetic-risk-score-for-type-2-diabetes-and-traits-related-to-glucose-insulin-homeostasis-in-youth-the-exploring-perinatal-outcomes-among-children-epoch-study
#9
Maggie A Stanislawski, Elizabeth Litkowski, Sridharan Raghavan, Kylie K Harrall, Jessica Shaw, Deborah H Glueck, Ethan M Lange, Dana Dabelea, Leslie A Lange
OBJECTIVE: The metabolic phenotype of youth-onset type 2 diabetes (T2D) differs from that of adult-onset T2D, but little is known about genetic contributions. We aimed to evaluate the association between a T2D genetic risk score (GRS) and traits related to glucose-insulin homeostasis among healthy youth. RESEARCH DESIGN AND METHODS: We used data from 356 youth (mean age 16.7 years; 50% female) in the Exploring Perinatal Outcomes Among Children (EPOCH) cohort to calculate a standardized weighted GRS based on 271 single nucleotide polymorphisms associated with T2D in adults...
July 13, 2021: Diabetes Care
https://read.qxmd.com/read/34253561/atherogenic-dyslipidemia-on-admission-is-associated-with-poorer-outcome-in-people-with-and-without-diabetes-hospitalized-for-covid-19
#10
Alfonso Bellia, Aikaterini Andreadi, Luca Giudice, Sofia De Taddeo, Alessio Maiorino, Ilenia D'Ippolito, Federica Maria Giorgino, Valeria Ruotolo, Maria Romano, Andrea Magrini, Nicola Di Daniele, Paola Rogliani, Davide Lauro
OBJECTIVE: Identifying metabolic factors associated with critical disease can help to improve management of patients hospitalized for coronavirus disease 2019 (COVID-19). High triglycerides and low HDL levels characterize the atherogenic dyslipidemia closely related to insulin resistance and diabetes. We examined associations of atherogenic dyslipidemia detected on admission with outcome of COVID-19 during hospitalization. RESEARCH DESIGN AND METHODS: We retrospectively analyzed clinical reports of 118 consecutive patients hospitalized for COVID-19 in Rome, Italy, between March and May 2020...
July 12, 2021: Diabetes Care
https://read.qxmd.com/read/34253560/the-association-of-fried-meat-consumption-with-the-gut-microbiota-and-fecal-metabolites-and-its-impact-on-glucose-homoeostasis-intestinal-endotoxin-levels-and-systemic-inflammation-a-randomized-controlled-feeding-trial
#11
Jian Gao, Xiaoyu Guo, Wei Wei, Ran Li, Ke Hu, Xin Liu, Wenbo Jiang, Siyao Liu, Weiqi Wang, Hu Sun, Huanyu Wu, Yuntao Zhang, Wenbo Gu, Ying Li, Changhao Sun, Tianshu Han
OBJECTIVE: This randomized controlled-feeding trial aimed to determine the impact of fried meat intake on the gut microbiota and fecal cometabolites and whether such impacts influenced host glucose homoeostasis, intestinal endotoxin levels, and systemic inflammation. RESEARCH DESIGN AND METHODS: A total of 117 overweight adults were randomized into two groups. Fifty-nine participants were provided fried meat four times per week, and 58 participants were restricted from fried meat intake, while holding food group and nutrient compositions constant, for 4 weeks...
July 12, 2021: Diabetes Care
https://read.qxmd.com/read/34244333/diabetes-and-covid-19-population-impact-18-months-into-the-pandemic
#12
Edward W Gregg, Marisa K Sophiea, Misghina Weldegiorgis
Eighteen months into the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) pandemic, epidemiologic studies indicate that diabetes is a central contributor to severe COVID-19 morbidity, and, conversely, COVID-19 has had a devastating effect on the population with diabetes. In this literature synthesis, we summarize the relationship of diabetes to COVID-19-related morbidity and mortality, discuss the predictors of severe adverse outcomes and implications of the overall pandemic, and critique the current status of and identify needs for epidemiologic studies for the next phase of the pandemic...
July 9, 2021: Diabetes Care
https://read.qxmd.com/read/34244331/diabetes-obesity-covid-19-insulin-and-other-antidiabetes-drugs
#13
Paresh Dandona, Husam Ghanim
Coronavirus disease 2019 (COVID-19) viral infection, like other infections, triggers an inflammatory response that is usually confined to the respiratory system. However, there is evidence that in a full-blown case, almost all systems of the body may be involved. In addition, there is the syndrome of cytokine storm, characterized by severe systemic inflammation and a massive release of proinflammatory cytokines (1). It is well established that obesity and diabetes are major risk factors for COVID-19 infections and that the morbidity and mortality in association with these conditions is markedly increased...
July 8, 2021: Diabetes Care
https://read.qxmd.com/read/34244330/rising-rates-and-widening-socioeconomic-disparities-in-diabetic-ketoacidosis-in-type-1-diabetes-in-scotland-a-nationwide-retrospective-cohort-observational-study
#14
Joseph E O'Reilly, Anita Jeyam, Thomas M Caparrotta, Joseph Mellor, Andreas Hohn, Paul M McKeigue, Stuart J McGurnaghan, Luke A K Blackbourn, Rory McCrimmon, Sarah H Wild, John R Petrie, John A McKnight, Brian Kennon, John Chalmers, Sam Phillip, Graham Leese, Robert S Lindsay, Naveed Sattar, Fraser W Gibb, Helen M Colhoun
OBJECTIVE: Whether advances in the management of type 1 diabetes are reducing rates of diabetic ketoacidosis (DKA) is unclear. We investigated time trends in DKA rates in a national cohort of individuals with type 1 diabetes monitored for 14 years, overall and by socioeconomic characteristics. RESEARCH DESIGN AND METHODS: All individuals in Scotland with type 1 diabetes who were alive and at least 1 year old between 1 January 2004 and 31 December 2018 were identified using the national register ( N = 37,939)...
July 8, 2021: Diabetes Care
https://read.qxmd.com/read/34244329/circulating-free-fatty-acid-and-phospholipid-signature-predicts-early-rapid-kidney-function-decline-in-patients-with-type-1-diabetes
#15
Farsad Afshinnia, Thekkelnaycke M Rajendiran, Chenchen He, Jaeman Byun, Daniel Montemayor, Manjula Darshi, Jana Tumova, Jiwan Kim, Christine P Limonte, Rachel G Miller, Tina Costacou, Trevor J Orchard, Tarunveer S Ahluwalia, Peter Rossing, Janet K Snell-Bergeon, Ian H de Boer, Loki Natarajan, George Michailidis, Kumar Sharma, Subramaniam Pennathur
OBJECTIVE: Patients with type 1 diabetes (T1D) exhibit modest lipid abnormalities as measured by traditional metrics. This study aimed to identify lipidomic predictors of rapid decline of kidney function in T1D. RESEARCH DESIGN AND METHODS: In a case-control study, 817 patients with T1D from three large cohorts were randomly split into training and validation subsets. Case was defined as >3 mL/min/1.73 m2 per year decline in estimated glomerular filtration rate (eGFR), while control was defined as <1 mL/min/1...
July 8, 2021: Diabetes Care
https://read.qxmd.com/read/34244332/historical-hba-1c-values-may-explain-the-type-2-diabetes-legacy-effect-ukpds-88
#16
Marcus Lind, Henrik Imberg, Ruth L Coleman, Olle Nerman, Rury R Holman
OBJECTIVE: Type 2 diabetes all-cause mortality (ACM) and myocardial infarction (MI) glycemic legacy effects have not been explained. We examined their relationships with prior individual HbA1c values and explored the potential impact of instituting earlier, compared with delayed, glucose-lowering therapy. RESEARCH DESIGN AND METHODS: Twenty-year ACM and MI hazard functions were estimated from diagnosis of type 2 diabetes in 3,802 UK Prospective Diabetes Study participants...
July 7, 2021: Diabetes Care
https://read.qxmd.com/read/34233928/the-effect-of-dapagliflozin-on-albuminuria-in-declare-timi-58
#17
Ofri Mosenzon, Stephen D Wiviott, Hiddo J L Heerspink, Jamie P Dwyer, Avivit Cahn, Erica L Goodrich, Aliza Rozenberg, Meir Schechter, Ilan Yanuv, Sabina A Murphy, Thomas A Zelniker, Ingrid A M Gause-Nilsson, Anna Maria Langkilde, Martin Fredriksson, Peter A Johansson, Deepak L Bhatt, Lawrence A Leiter, Darren K McGuire, John P H Wilding, Marc S Sabatine, Itamar Raz
OBJECTIVE: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve albuminuria in patients with high cardiorenal risk. We report albuminuria change in the Dapagliflozin Effect on Cardiovascular Events (DECLARE-TIMI 58) cardiovascular outcome trial, which included populations with lower cardiorenal risk. RESEARCH DESIGN AND METHODS: DECLARE-TIMI 58 randomized 17,160 patients with type 2 diabetes, creatinine clearance >60 mL/min, and either atherosclerotic cardiovascular disease (CVD; 40...
July 7, 2021: Diabetes Care
https://read.qxmd.com/read/34233927/modification-of-the-association-between-severe-hypoglycemia-and-ischemic-heart-disease-by-surrogates-of-vascular-damage-severity-in-type-1-diabetes-during-%C3%A2-30-years-of-follow-up-in-the-dcct-edic-study
#18
Elke R Fahrmann, Laura Adkins, Henry K Driscoll
OBJECTIVE: Literature suggests that severe hypoglycemia (SH) may be linked to cardiovascular events only in older individuals with high cardiovascular risk score (CV-score). Whether a potential relationship between any-SH and cardiovascular disease exists and whether it is conditional on vascular damage severity in a young cohort with type 1 diabetes (T1D) without apparent macrovascular and no or mild-to-moderate microvascular complications at baseline is unknown. RESEARCH DESIGN AND METHODS: Time-dependent associations between any-SH and ischemic heart disease (IHD: death, silent/nonfatal myocardial infarct, revascularization, or confirmed angina) and associations between interactions of any-SH with surrogates of baseline micro-/macrovascular damage severity and IHD were analyzed...
July 7, 2021: Diabetes Care
https://read.qxmd.com/read/34233926/excess-mortality-in-covid-19-positive-versus-covid-19-negative-inpatients-with-diabetes-a-nationwide-study
#19
LETTER
Elias K Spanakis, Ashley Yoo, Oluwagbemiga N Ajayi, Tariq Siddiqui, Mohd M Khan, Stephen L Seliger, David C Klonoff, Zhaoyong Feng, John D Sorkin
No abstract text is available yet for this article.
July 7, 2021: Diabetes Care
https://read.qxmd.com/read/34233925/chronic-kidney-disease-testing-among-primary-care-patients-with-type-2-diabetes-across-24-u-s-health-care-organizations
#20
Nikita Stempniewicz, Joseph A Vassalotti, John K Cuddeback, Elizabeth Ciemins, Amy Storfer-Isser, Yingying Sang, Kunihiro Matsushita, Shoshana H Ballew, Alex R Chang, Andrew S Levey, Robert A Bailey, Jesse Fishman, Josef Coresh
OBJECTIVE: Clinical guidelines for people with diabetes recommend chronic kidney disease (CKD) testing at least annually using estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (uACR). We aimed to understand CKD testing among people with type 2 diabetes in the U.S. RESEARCH DESIGN AND METHODS: Electronic health record data were analyzed from 513,165 adults with type 2 diabetes receiving primary care from 24 health care organizations and 1,164 clinical practice sites...
July 7, 2021: Diabetes Care
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