Diabetes Care

Axel Dost, Susanne Bechtold, Katharina Fink, Walter Bonfig, Dagobert Wiemann, Thomas M Kapellen, Michael Witsch, Karl O Schwab, Reinhard W Holl
OBJECTIVE: In 2017, the American Academy of Pediatrics introduced a new guideline (2017 Clinical Practice Guideline of the American Academy of Pediatrics [AAP 2017]) to diagnose arterial hypertension (HTN) in children that included revised, lower normative blood pressure (BP) values and cut points for diagnosing high BP in adolescents. We studied the impact of the new AAP 2017 guideline on prevalence of HTN in children with type 1 diabetes mellitus (T1DM). RESEARCH DESIGN AND METHODS: Up to September 2018, 1...
March 30, 2020: Diabetes Care
Chang-Sheng Sheng, Jingyan Tian, Ya Miao, Yi Cheng, Yulin Yang, Peter D Reaven, Zachary T Bloomgarden, Guang Ning
OBJECTIVE: The association between high glycemic variability and all-cause mortality has been widely investigated in epidemiological studies but rarely validated in glucose-lowering clinical trials. We aimed to identify the prognostic significance of visit-to-visit HbA1c variability in treated patients in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial population. RESEARCH DESIGN AND METHODS: We studied the risk of all-cause mortality in relation to long-term visit-to-visit HbA1c variability, expressed as coefficient of variation (CV), variability independent of the mean (VIM), and average real variability (ARV), from the 8th month to the transition...
March 30, 2020: Diabetes Care
Gaurav S Gulsin, Daniel J Swarbrick, Lavanya Athithan, Emer M Brady, Joseph Henson, Emma Baldry, Stavroula Argyridou, Nishal B Jaicim, Gareth Squire, Yvette Walters, Anna-Marie Marsh, John McAdam, Kelly S Parke, John D Biglands, Thomas Yates, Kamlesh Khunti, Melanie J Davies, Gerry P McCann
OBJECTIVE: To confirm the presence of subclinical cardiovascular dysfunction in working-age adults with type 2 diabetes (T2D) and determine whether this is improved by a low-energy meal replacement diet (MRP) or exercise training. RESEARCH DESIGN AND METHODS: This article reports on a prospective, randomized, open-label, blinded end point trial with nested case-control study. Asymptomatic younger adults with T2D were randomized 1:1:1 to a 12-week intervention of 1 ) routine care, 2 ) supervised aerobic exercise training, or 3 ) a low-energy (∼810 kcal/day) MRP...
March 27, 2020: Diabetes Care
Ali Muhammed Ali, Robert Martinez, Hussein Al-Jobori, John Adams, Curtis Triplitt, Ralph DeFronzo, Eugenio Cersosimo, Muhammad Abdul-Ghani
OBJECTIVE: To examine the effect of combination therapy with canagliflozin plus liraglutide on HbA1c , endogenous glucose production (EGP), and body weight versus each therapy alone. RESEARCH DESIGN AND METHODS: Forty-five patients with poorly controlled (HbA1c 7-11%) type 2 diabetes mellitus (T2DM) on metformin with or without sulfonylurea received a 9-h measurement of EGP with [3-3 H]glucose infusion, after which they were randomized to receive 1 ) liraglutide 1...
March 27, 2020: Diabetes Care
Ming-Chieh Tsai, Kai-Liang Kao, Hui-Chun Huang, Weishan Chen, Chun-Kai Fang, Fung-Chang Sung, Shu-I Wu, Robert Stewart
No abstract text is available yet for this article.
March 24, 2020: Diabetes Care
Wendy S Lane, Elena Favaro, Naveen Rathor, Hak C Jang, Maiken I S Kjærsgaard, Alejandra Oviedo, Ludger Rose, Peter Senior, Giorgio Sesti, Alfonso Soto Gonzalez, Edward Franek
OBJECTIVE: To evaluate the efficacy and safety of fast-acting insulin aspart (faster aspart) compared with insulin aspart (IAsp), both with insulin degludec with or without metformin, in adults with type 2 diabetes not optimally controlled with a basal-bolus regimen. RESEARCH DESIGN AND METHODS: This multicenter, double-blind, treat-to-target trial randomized participants to faster aspart ( n = 546) or IAsp ( n = 545). All available information, regardless of treatment discontinuation or use of ancillary treatment, was used for evaluation of effect...
March 24, 2020: Diabetes Care
Megu Y Baden, Frank B Hu, Celine Vetter, Eva Schernhammer, Susan Redline, Tianyi Huang
OBJECTIVE: To identify sleep duration trajectories from early to middle adulthood and their associations with incident type 2 diabetes. RESEARCH DESIGN AND METHODS: Using a group-based modeling approach, we identified sleep duration trajectories based on sleep duration in ages 20-25, 26-35, 36-45, and 46+ years, which were retrospectively assessed in 2009 among 60,068 women from the Nurses' Health Study II (median age 54.9 years) who were free of diabetes, cardiovascular disease, and cancer...
March 24, 2020: Diabetes Care
Eleanor M Scott, Denice S Feig, Helen R Murphy, Graham R Law
OBJECTIVE: To determine if temporal glucose profiles differed between 1 ) women who were randomized to real-time continuous glucose monitoring (RT-CGM) or self-monitored blood glucose (SMBG), 2 ) women who used insulin pumps or multiple daily insulin injections (MDIs), and 3 ) women whose infants were born large for gestational age (LGA) or not, by assessing CGM data obtained from the Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial (CONCEPTT). RESEARCH DESIGN AND METHODS: Standard summary metrics and functional data analysis (FDA) were applied to CGM data from the CONCEPTT trial (RT-CGM, n = 100; SMBG, n = 100) taken at baseline and at 24- and 34-weeks gestation...
March 24, 2020: Diabetes Care
Jingyan Tian, Toshiaki Ohkuma, Mark Cooper, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Ji-Guang Wang, Sophia Zoungas, Mark Woodward, John Chalmers
OBJECTIVE: To study whether the effects of intensive glycemic control on major vascular outcomes (a composite of major macrovascular and major microvascular events), all-cause mortality, and severe hypoglycemia events differ among participants with different levels of 10-year risk of atherosclerotic cardiovascular disease (ASCVD) and hemoglobin A1c (HbA1c ) at baseline. RESEARCH DESIGN AND METHODS: We studied the effects of more intensive glycemic control in 11,071 patients with type 2 diabetes (T2D), without missing values, in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial, using Cox models...
March 19, 2020: Diabetes Care
Martin H Sørensen, Annemie S Bojer, Julie R N Pontoppidan, David A Broadbent, Sven Plein, Per L Madsen, Peter Gæde
OBJECTIVE: To examine differences in myocardial blood flow (MBF) at rest and during stress between patients with type 2 diabetes and controls, and to identify potential predictors of changes in MBF at rest and during stress. RESEARCH DESIGN AND METHODS: A cross-sectional study of 193 patients with type 2 diabetes and 20 age- and sex-matched controls. Cardiovascular magnetic resonance was used in order to evaluate left ventricular structure and function, and MBF at rest and during adenosine-induced stress...
March 19, 2020: Diabetes Care
Ali Aminian, Gautam Sharma, Rickesha L Wilson, Sangeeta R Kashyap, Emanuele Lo Menzo, Samuel Szomstein, Raul J Rosenthal, Philip R Schauer, Roman Vangoitsenhoven
No abstract text is available yet for this article.
March 18, 2020: Diabetes Care
Jun Jie Benjamin Seng, Yu Heng Kwan, Vivian Shu Yi Lee, Chuen Seng Tan, Sueziani Binte Zainudin, Julian Thumboo, Lian Leng Low
OBJECTIVE: With rising health care costs and finite health care resources, understanding the population needs of different type 2 diabetes mellitus (T2DM) patient subgroups is important. Sparse data exist for the application of population segmentation on health care needs among Asian T2DM patients. We aimed to segment T2DM patients into distinct classes and evaluate their differential health care use, diabetes-related complications, and mortality patterns. RESEARCH DESIGN AND METHODS: Latent class analysis was conducted on a retrospective cohort of 71,125 T2DM patients...
March 18, 2020: Diabetes Care
Yang-Hyun Kim, Jun Goo Kang, Seong Jin Lee, Kyung-do Han, Sung-Hee Ihm, Kyung-Hwan Cho, Yong-Gyu Park
OBJECTIVE: There is a controversy over the association between obesity and end-stage renal disease (ESRD) in people with or without type 2 diabetes; therefore, we examined the effect of BMI on the risk of ESRD according to glycemic status in the Korean population. RESEARCH DESIGN AND METHODS: The study monitored 9,969,848 participants who underwent a National Health Insurance Service health checkup in 2009 from baseline to the date of diagnosis of ESRD during a follow-up period of ∼8...
March 18, 2020: Diabetes Care
Sam N Scott, Mark P Christiansen, Federico Y Fontana, Christoph Stettler, Richard M Bracken, Charlotte A Hayes, Miles Fisher, Bruce Bode, Peter H Lagrou, Phil Southerland, Michael C Riddell
OBJECTIVE: To investigate factors related to glycemic management among members of a professional cycling team with type 1 diabetes over a 7-day Union Cycliste Internationale World Tour stage race. RESEARCH DESIGN AND METHODS: An observational evaluation of possible factors related to glycemic management and performance in six male professional cyclists with type 1 diabetes (HbA1c 6.4 ± 0.6%) during the 2019 Tour of California. RESULTS: In-ride time spent in euglycemia (3...
March 16, 2020: Diabetes Care
Matthew J Singleton, Charles A German, Alain G Bertoni, Walter T Ambrosius, Prashant D Bhave, Elsayed Z Soliman, Joseph Yeboah
No abstract text is available yet for this article.
March 16, 2020: Diabetes Care
Siôn A Parry, Fredrik Rosqvist, Ferenc E Mozes, Thomas Cornfield, Matthew Hutchinson, Marie-Eve Piche, Andreas J Hülsmeier, Thorsten Hornemann, Pamela Dyson, Leanne Hodson
OBJECTIVE: Debate continues regarding the influence of dietary fats and sugars on the risk of developing metabolic diseases, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). We investigated the effect of two eucaloric diets, one enriched with saturated fat (SFA) and the other enriched with free sugars (SUGAR), on intrahepatic triacylglycerol (IHTAG) content, hepatic de novo lipogenesis (DNL), and whole-body postprandial metabolism in overweight males. RESEARCH DESIGN AND METHODS: Sixteen overweight males were randomized to consume the SFA or SUGAR diet for 4 weeks before consuming the alternate diet after a 7-week washout period...
March 12, 2020: Diabetes Care
Louisa Sukkar, Amy Kang, Carinna Hockham, Tamara Young, Min Jun, Celine Foote, Roberto Pecoits-Filho, Brendon Neuen, Kris Rogers, Carol Pollock, Alan Cass, David Sullivan, Germaine Wong, John Knight, David Peiris, Martin Gallagher, Meg Jardine
OBJECTIVE: To determine the incidence of and factors associated with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 in people with diabetes. RESEARCH DESIGN AND METHODS: We identified people with diabetes in the EXamining ouTcomEs in chroNic Disease in the 45 and Up Study (EXTEND45), a population-based cohort study (2006-2014) that linked the Sax Institute's 45 and Up study cohort to community laboratory and administrative data in New South Wales, Australia...
March 11, 2020: Diabetes Care
Dhruv Mahtta, Sarah T Ahmed, Nishant R Shah, David J Ramsey, Julia M Akeroyd, Khurram Nasir, Ihab R Hamzeh, Islam Y Elgendy, Stephen W Waldo, Mouaz H Al-Mallah, Hani Jneid, Christie M Ballantyne, Laura A Petersen, Salim S Virani
No abstract text is available yet for this article.
March 11, 2020: Diabetes Care
Charlotte Coopmans, Tan Lai Zhou, Ronald M A Henry, Jordi Heijman, Nicolaas C Schaper, Annemarie Koster, Miranda T Schram, Carla J H van der Kallen, Anke Wesselius, Robert J A den Engelsman, Harry J G M Crijns, Coen D A Stehouwer
OBJECTIVE: Low heart rate variability (HRV), a marker for cardiac autonomic dysfunction, is a known feature of type 2 diabetes, but it remains incompletely understood whether this also applies to prediabetes or across the whole glycemic spectrum. Therefore, we investigated the association among prediabetes, type 2 diabetes, and measures of glycemia and HRV. RESEARCH DESIGN AND METHODS: In the population-based Maastricht Study ( n = 2,107; aged 59 ± 8 years; 52% men; normal glucose metabolism [ n = 1,226], prediabetes [ n = 331], and type 2 diabetes [ n = 550, oversampled]), we determined 24-h electrocardiogram-derived HRV in time and frequency domains (individual z -scores, based upon seven and six variables, respectively)...
March 11, 2020: Diabetes Care
Stephen R Benoit, Israel Hora, Francisco J Pasquel, Edward W Gregg, Ann L Albright, Giuseppina Imperatore
OBJECTIVE: To report U.S. national population-based rates and trends in diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) among adults, in both the emergency department (ED) and inpatient setting. RESEARCH DESIGN AND METHODS: We analyzed data from 1 January 2006 through 30 September 2015 from the Nationwide Emergency Department Sample and National Inpatient Sample to characterize ED visits and inpatient admissions with DKA and HHS. We used corresponding year cross-sectional survey data from the National Health Interview Survey to estimate the number of adults ≥18 years with diagnosed diabetes to calculate population-based rates for DKA and HHS in both ED and inpatient settings...
March 11, 2020: Diabetes Care
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