Journals Dementia and Geriatric Cogniti...

Dementia and Geriatric Cognitive Disorders
Jianwei Li, Jie Li, Huafang Zhu, Mengyu Liu, Tengfei Li, Yeke He, Yuan Xu, Fen Huang, Qirong Qin
Detecting cognitive decline early in the older adults is crucial for effective intervention. This study, part of the Ma'anshan Healthy Aging Cohort Study, examined 2,288 participants with normal cognitive function. Forty-two potential predictors, including demographics, chronic diseases, lifestyle factors, and baseline cognitive function, were selected. The dataset was divided into training, validation, and test sets (60%, 20%, and 20%, respectively). Recursive feature elimination (RFE) and six machine learning algorithms were used for model development...
May 22, 2024: Dementia and Geriatric Cognitive Disorders
Atefeh Kiadarbandsari, Miraneta Tafue Lemalu, Sharyn Wilson, Fuafiva Fa'alau
BACKGROUND: Dementia as a neurocognitive disorder is becoming increasingly common worldwide, and minority groups are more vulnerable than the general population. Many factors may contribute to their vulnerability such as misconceptions, language barriers, cultural factors, invalid assessment tools, lack of knowledge or assigning spiritual beliefs to dementia symptoms. Therefore, this scoping literature review aims to clarify how empirical studies reflect the meaning of dementia, language, and translation among minority ethnic groups...
May 22, 2024: Dementia and Geriatric Cognitive Disorders
Rosa Montesinos, Belen Custodio, Marco Malaga, Diego Chambergo-Michilot, Graciet Verastegui-Aranda, Katherine Agüero, Juan Alejos-Zirena, Luis Andamayo-Villalba, Wendy Seminario G, Nilton Custodio
INTRODUCTION: People caring of individuals with dementia are prone to suffering from burden. Behavioral and psychological symptoms of dementia (BPSD) may have an impact on caregiver burden. In Latin American countries there is lack of research on caregiver burden. We aimed to determine which BPSD have the greatest impact on caregiver burden among Peruvian patients with dementia; and to compare the effects of BPSD on caregiver burden across different types of dementia. METHODS: Cross-sectional study of 231 patients living with Alzheimer's dementia (AD), behavioral variant frontotemporal dementia (bvFTD), dementia with Lewy bodies (DLB) and vascular dementia (VD), and their caregivers attended in a Peruvian memory clinic...
May 20, 2024: Dementia and Geriatric Cognitive Disorders
Frédéric Noublanche, Grégory Ben-Sadoun, Lena Carcreff, Jennifer Gautier, Philippe Allain, Cédric Annweiler
INTRODUCTION: The objectives of this study were to determine the participation rates, levels of engagement and abilities to answer User eXperience (UX) questionnaires according to the presence and severity of major neurocognitive disorders (MNCD) among participants involved in gerontechnological experimentations within a hospital-based geriatric clinical living lab. METHODS: Cross-sectional analysis examining all consecutive geriatric patients involved in the Allegro living lab experimentations, separated according to the presence and severity of MNCD...
April 27, 2024: Dementia and Geriatric Cognitive Disorders
Raul Vintimilla, Abigail Benton, Roya Morakabian, James R Hall, Leigh A Johnson, Sid E O'Bryant
INTRODUCTION: Neighborhood socioeconomic status (NSES) has been linked with overall health, and this study will evaluate whether NSES is cross-sectionally associated with cognition in non-Hispanic Whites (NHW) and Mexican Americans (MA) from the Health and Aging Brain: Health Disparities Study (HABS-HD). METHODS: The HABS-HD is a longitudinal study conducted at the University of North Texas Health Science Center. The final sample analyzed (n=1312) were 50 years or older, with unimpaired cognition, and underwent an interview, neuropsychological examination, imaging, and blood draw...
April 25, 2024: Dementia and Geriatric Cognitive Disorders
Vasudevan Ramachandran, Nur Afiqah Mohamad, Mohd Nazil Salleh, Wan Aliaa Wan Sulaiman, Liyana Najwa Inche Mat, Mohd Hazmi Mohamed, Ching Siew Mooi, Abdul Hanif Khan Yusof Khan, Hamidon Basri, Pannerselvam Periasamy, Vajiravelu Suganthi, Narenkumar Jayaraman
INTRODUCTION: Vascular dementia (VaD), a neurocognitive impairment directly related to vascular injury, is the second most common cause of age-related dementia. Although numerous studies have investigated candidate genetic polymorphisms associated with VaD in Asia, the genetics of VaD remains unclear. METHODS: This review provides an updated meta-analysis of genetic polymorphisms associated with VaD in Asians, using the PRISMA guidelines. Published literature up to May 2021 was extracted from the PubMed, Scopus, Ovid, and EBSCO host databases...
April 18, 2024: Dementia and Geriatric Cognitive Disorders
Keita Nakagawa, Shusaku Kanai, Sosuke Kitakaze, Hitoshi Okamura
INTRODUCTION: When determining the level of gait independence in patients with Alzheimer's disease (AD), detailed functional assessment is difficult in some patients. Previous literature has suggested simple standing balance tests for patients with AD due to their ease of implementation in clinical practice and relevance to gait. However, their usefulness for discriminating the level of gait independence remains unclear. This study aimed to investigate the discrimination accuracy of a simple standing balance test in the level of gait independence among hospitalized patients with AD...
April 10, 2024: Dementia and Geriatric Cognitive Disorders
Yafei Wu, Zongjie Wang, Ya Fang
INTRODUCTION: The relationship between cognitive function and subsequent sarcopenia remains unclear. Therefore, this study aimed to examine the associations of performance on multiple cognitive domains with sarcopenia in the middle-aged and older adults. METHODS: This longitudinal analysis (wave 2011-2013) included 2934 participants from the CHARLS study. Sarcopenia was defined by the Asian Sarcopenia Working Group 2019 criteria. Cognitive function was measured by the Chinese version of the Mini-Mental State Examination (MMSE)...
April 9, 2024: Dementia and Geriatric Cognitive Disorders
Lucas Nogueira de Carvalho Pelegrini, Vanessa Alexandre da Silva, Marina Mantellato Grigoli, Izabela Pereira Vatanabe, Patricia Regina Manzine, Marcia Regina Cominetti
INTRODUCTION: Low educational attainment is a potential risk factor for Alzheimer's disease (AD) development. Alpha-secretase ADAM10 plays a central role in AD pathology, attenuating the formation of beta-amyloid peptides and, therefore, their aggregation into senile plaques. This study seeks to investigate ADAM10 as a blood-based biomarker in mild cognitive impairment (MCI) and AD in a diverse group of community-dwelling older adults, focusing on those with limited educational attainment...
April 6, 2024: Dementia and Geriatric Cognitive Disorders
Ping Lin, Jiandong Wang, Yuyan Li, Guofeng Li, Ying Wang
OBJECTIVE: To explore the molecular mechanism of long non-coding RNA (lncRNA) LINC00472 in Alzheimer's Disease (AD). METHOD: Ferroptosis-related lncRNAs were screened by GEO database. AD mouse model was constructed for in vivo experimental. The content of Aβ protein and Tau protein hyperphosphorylation were examined in Hippocampal tissue samples of mice. Subsequently, HT22 cells were induced with Aβ25-35 to establish a neuronal injury model of AD in vitro...
April 4, 2024: Dementia and Geriatric Cognitive Disorders
Chen-Wen Fang, Cheng-Yi Yang, Hephaes Chuen Chau, Meng-Che Tsai
INTRODUCTION: The potential influence of age at menarche (AM) on cognitive aging remains inadequate, partly because of the difficulties presented by multiple confounders. To address this issue, the Mendelian randomization (MR) analysis was used to explore the causal impacts of AM on cognitive aging. METHODS: Using the publicly accessible Taiwan Biobank, we identified single nucleotide polymorphisms (SNPs) significantly associated with AM as instrumental variables to estimate the effects of instruments on cognitive function assessed with the Mini-Mental State Examination (MMSE)...
April 1, 2024: Dementia and Geriatric Cognitive Disorders
Breanna M Bullard, Casey L Brown, Julian A Scheffer, Anna B Toledo, Robert W Levenson
INTRODUCTION: Providing care for a loved one with dementia can engender intense emotions that contribute to symptoms of anxiety and depression. Caregivers often attempt to regulate their emotions using strategies like cognitive reappraisal (CR; changing how they think about the situation) or expressive suppression (ES; hiding their emotions). However, men and women caregivers may differ in their use of these strategies. The current study examines gender differences in reported CR and ES usage and their associations with depression and anxiety in dementia caregivers...
March 27, 2024: Dementia and Geriatric Cognitive Disorders
Eva Q Gontrum, Emily W Paolillo, Shannon Lee, Valentina Diaz, Alexander Ehrenberg, Rowan Saloner, Nidhi S Mundada, Renaud La Joie, Gil Rabinovici, Joel H Kramer, Kaitlin Casaletto
INTRODUCTION: We comprehensively evaluated how self- and informant-reported neuropsychiatric symptoms (NPS) differentially associated with cerebral amyloid-beta (Aβ) PET levels in older adults without dementia. METHODS: 221 participants (48% female, age=73.4y±8.4, CDR=0 [n=184] or 0.5 [n=37]) underwent an Aβ-PET scan (Florbetapir or PIB), comprehensive neuropsychological testing, and self-reported (Geriatric Depression Scale- 30 item), and informant-reported interview (Neuropsychiatric Inventory Questionnaire) of NPS...
March 21, 2024: Dementia and Geriatric Cognitive Disorders
Donnchadh F Murphy, Jonathan P Scott, Rupert F Noad
Cognitive screening measures are an established part of a dementia assessment, and often include measures of subjective difficulties, e.g., Everyday Memory Questionnaire (EMQ), informant rated difficulty, e.g., Cambridge Behavioural Inventory (CBI-R), and objective cognitive assessments, e.g., Addenbrooke's Cognitive Examination (ACE-III). While these measures have validity for the purpose of diagnosing dementia, in clinical practice they are often used outside of their evidence base, for the purpose of cognitive re-assessment...
March 13, 2024: Dementia and Geriatric Cognitive Disorders
Oanh L Meyer, Krystal Nguyen, Bora Nam, Janice Y Tsoh, Ladson Hinton, Dolores Gallagher-Thompson, Joshua Grill, Quyen Vuong, Van Ta Park
INTRODUCTION: We elicited Vietnamese Americans' perspectives on culturally appropriate recruitment into a new research registry: Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders (AANHPIs) Research and Education (CARE). METHODS: Three focus groups were conducted with 21 Vietnamese Americans. Topics included knowledge about and experiences with research, outreach and recruitment methods for research participation and registry enrollment, and views about research incentives...
February 29, 2024: Dementia and Geriatric Cognitive Disorders
Yuan-Fei Cao, Guo-Ping Shi, Hui Zhang, Meng-Zhen Sun, Zheng-Dong Wang, Xue-Feng Chu, Jiang-Hong Guo, Xiao-Feng Wang
Introduction Previous studies have indicated a correlation between perceived stress and cognitive decline. However, it remains unknown whether high levels of perceived stress can result in motoric cognitive risk (MCR) syndrome. This study investigated the relationship between perceived stress and MCR in a community-based population. Methods The study cohort comprised 852 elderly individuals from the Rugao Longitudinal Aging Cohort. Perceived stress was assessed using the 10-item Perceived Stress Scale (PSS-10), while MCR was defined as the coexistence of subjective memory complaints (SMCs) and slow gait speed...
February 26, 2024: Dementia and Geriatric Cognitive Disorders
Pildoo Sung, Angelique Chan, Jeremy Lim-Soh
INTRODUCTION: Loneliness in older persons with cognitive impairment (PCI) may beget loneliness in their family caregivers, depending on buffering resources caregivers possess. This study examined the association between loneliness in older persons with cognitive impairment (PCI) and loneliness experienced by their family caregivers, and the moderating role of caregiver mastery in this association. METHODS: Dyadic data from 135 PCI and their family caregivers in Singapore were analyzed using multivariable regression...
February 14, 2024: Dementia and Geriatric Cognitive Disorders
Aaron Jones, Muhammad Usman Ali, Meghan Kenny, Alexandra Mayhew, Vishal Mokashi, Henry He, Sabrina Lin, Ehsan Yavari, Karen Paik, Deejesh Subramanian, Robert Dydynsky, Komal Aryal, Rebecca H Correia, Darly Dash, Derek R Manis, Megan O'Connell, Teresa Liu-Ambrose, Vanessa Taler, Jacqueline M McMillan, David B Hogan, Susan Kirkland, Andrew P Costa, Christina Wolfson, Parminder Raina, Lauren Griffith
Introduction The prevalence of mild and major neurocognitive disorders (NCDs), also referred to as mild cognitive impairment and dementia, is rising globally. The prevention of NCDs is a major global public health interest. We sought to synthesize the literature on potentially modifiable risk factors for NCDs. Methods We conducted an umbrella review using a systematic search across multiple databases to identify relevant systematic reviews and meta-analyses. Eligible reviews examined potentially modifiable risk factors for mild or major NCDs...
February 12, 2024: Dementia and Geriatric Cognitive Disorders
Alberto Benussi, Irene Mattioli, Chiara Silvestri, Ilenia Libri, Silvio Zampini, Maura Cosseddu, Rosanna Turrone, Claudia Amolini, Salvatore Caratozzolo, Barbara Borroni, Alessandra Marengoni, Alessandro Padovani
INTRODUCTION: Neurodegenerative diseases are a growing concern in an aging global population. Frailty, often conceptualized as a state of diminished physiological reserve and increased susceptibility to stressors, emerges as a pivotal factor in this context. While frailty may be modified, it is essential to recognize its frequently irreversible nature, necessitating a careful approach when considering its role and influence in the progression from mild cognitive impairment (MCI) to dementia and within dementia progression...
2024: Dementia and Geriatric Cognitive Disorders
Yen-Jen Chen, Wen-Fu Wang, Ming-Che Chang, Kai-Ming Jhang
INTRODUCTION: This study aimed to investigate the influence of case management and its corresponding computer-assisted assessment system on the quality improvement of dementia care. METHODS: This observational study enrolled 2029 patients and their caregivers at Changhua Christian Hospital in Taiwan. Physicians who made the diagnosis of dementia would introduce the patient and caregiver dyad to the case manager-centered collaborative care team after obtaining agreement...
2024: Dementia and Geriatric Cognitive Disorders
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