journal
https://read.qxmd.com/read/37973023/neuroscience-and-oncology-state-of-the-art-and-new-perspectives
#41
REVIEW
Frank Winkler
PURPOSE OF REVIEW: Emerging discoveries suggest that both the central (CNS) and peripheral (PNS) nervous system are an important driver of cancer initiation, promotion, dissemination, and therapy resistance, not only in the brain but also in multiple cancer types throughout the body. This article highlights the most recent developments in this emerging field of research over the last year and provides a roadmap for the future, emphasizing its translational potential. RECENT FINDINGS: Excitatory synapses between neurons and cancer cells that drive growth and invasion have been detected and characterized...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37973022/editorial-advances-in-basic-science-and-technology-are-bringing-new-flavor-in-neuro-oncology
#42
JOURNAL ARTICLE
Riccardo Soffietti
No abstract text is available yet for this article.
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37973021/editorial-update-on-current-topics-in-spinal-cord-injury-trauma-and-rehabilitation
#43
JOURNAL ARTICLE
Ona Bloom, James Guest
No abstract text is available yet for this article.
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37889524/review-of-spinal-cord-stimulation-for-disorders-of-consciousness
#44
JOURNAL ARTICLE
Guilherme Santos Piedade, Bernardo Assumpcao de Monaco, James D Guest, Joacir Graciolli Cordeiro
PURPOSE OF REVIEW: High-cervical spinal cord stimulation can alter cortical activity and cerebral metabolism. These effects are potentially beneficial for disorders of consciousness. A better understanding of the effects of clinical application of stimulation is needed. We aimed to evaluate the existing literature to determine the state of available knowledge. We performed a literature review of clinical studies assessing cervical spinal cord epidural stimulation for disorders of consciousness...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865858/combination-of-radiosurgery-and-immunotherapy-in-brain-metastases-balance-between-efficacy-and-toxicities
#45
REVIEW
Angela Botticella, Frederic Dhermain
PURPOSE OF REVIEW: The incidence of brain metastasis is high and still increasing. Among local therapies, stereotactic radiosurgery (SRS) is an effective treatment option, optimally sparing normal brain, even for multiple brain metastases. Immune checkpoint inhibitors (ICIs) become the new standard of care in an increasing number of cancers, and the combination SRS and ICI is often proposed to patients, but few data have been published on the efficacy and the toxicity of this association...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865856/novel-approaches-to-treatment-of-leptomeningeal-metastases
#46
REVIEW
Ditte Primdahl, Adam Cohen-Nowak, Priya Kumthekar
PURPOSE OF REVIEW: The incidence of leptomeningeal metastases is increasing in the setting of improved survival from systemic cancers. In more recent years, our understanding of leptomeningeal metastasis pathogenesis, how to diagnose and treat has been evolving. RECENT FINDINGS: Diagnosing leptomeningeal metastasis has been challenging due to the limitations of cytology and neuroimaging; However, newer techniques detecting circulating tumor cells (CTCs) or circulating tumor DNA (ctDNA) have shown potential advantage with diagnosis, quantification and detection of oncogenic mutations...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865855/diet-and-migraine-what-is-proven
#47
REVIEW
Parisa Gazerani
PURPOSE OF REVIEW: The purpose of this review is to present the latest research findings about diet and migraine, what can be used in the clinic now, and what needs further investigation. RECENT FINDINGS: Recent findings highlight that dietary triggers exist for migraine, for example, coffee and alcohol, according to a new systematic review. Elimination diets must be personalized to delineate a balanced diet with acceptable quality and pattern. A piece of average-quality evidence shows that the ketogenic diet (KD) and the Dietary Approaches to Stop Hypertension (DASH) are effective in reducing the frequency, duration, and severity of migraine headaches in adult patients...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865854/novel-trial-designs-in-neuro-oncology
#48
REVIEW
Kun-Wei Song, Patrick Y Wen
PURPOSE OF REVIEW: An important factor contributing to the low rate of success in identifying effective therapies for brain tumor patients is the slow, inefficient, and expensive process of drug development, as well as small patient numbers, low patient participation in clinical trials, and reluctance of patients to enroll in ineffective control arms. In recent years, a number of novel trial designs have been developed to try to address some of these issues. RECENT FINDINGS: Surgical 'window-of-opportunity' trials that evaluate tumor drug concentrations and pharmacodynamic effects provide invaluable early data early guiding the development of novel therapies...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865852/idiopathic-intracranial-hypertension-expanding-our-understanding
#49
REVIEW
Keira Markey, Christopher Hutchcroft, Hedley Emsley
PURPOSE OF REVIEW: Idiopathic intracranial hypertension (IIH) affects predominantly overweight women of childbearing age, causing chronically-disabling headaches and visual loss. Weight loss remains the most effective management strategy, but innovative treatments and randomized control trials (RCTs) remain few. This paper will review recent IIH research. RECENT FINDINGS: Pregnancy-related complications, but not losses, are increased in IIH, while symptom severity is not affected...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865850/development-of-neural-repair-therapy-for-chronic-spinal-cord-trauma-soluble-nogo-receptor-decoy-from-discovery-to-clinical-trial
#50
JOURNAL ARTICLE
Elisa M Howard, Stephen M Strittmatter
PURPOSE OF REVIEW: After traumatic spinal cord injury (SCI), neurological deficits persist due to the disconnection of surviving neurons. While repair of connectivity may restore function, no medical therapy exists today.This review traces the development of the neural repair-based therapeutic AXER-204 from animal studies to the recent clinical trial for chronic cervical SCI. RECENT FINDINGS: Molecular studies reveal a Nogo-66 Receptor 1 (NgR1, RTN4R) pathway inhibiting axon regeneration, sprouting, and plasticity in the adult mammalian central nervous system (CNS)...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865849/how-to-evaluate-extent-of-resection-in-diffuse-gliomas-from-standards-to-new-methods
#51
REVIEW
Nico Teske, Joerg-Christian Tonn, Philipp Karschnia
PURPOSE OF REVIEW: Maximal safe tumor resection represents the current standard of care for patients with newly diagnosed diffuse gliomas. Recent efforts have highlighted the prognostic value of extent of resection measured as residual tumor volume in patients with isocitrate dehydrogenase (IDH)-wildtype and -mutant gliomas. Accurate assessment of such information therefore appears essential in the context of clinical trials as well as patient management. RECENT FINDINGS: Current recommendations for evaluation of extent of resection rest upon standardized postoperative MRI including contrast-enhanced T1-weighted sequences, T2-weighted/fluid-attenuated-inversion-recovery sequences, and diffusion-weighted imaging to differentiate postoperative tumor volumes from ischemia and nonspecific imaging findings...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865837/systemic-vasculitis-and-headache
#52
REVIEW
David S Younger
PURPOSE OF REVIEW: Vasculitis refers to heterogeneous clinicopathologic disorders that share the histopathology of inflammation of blood vessels. Unrecognized and therefore untreated, vasculitis of the nervous system or so called neurovasculitides, lead to pervasive injury and disability making these disorder of paramount importance to clinicians. RECENT FINDINGS: Headache is an important clue to vasculitic involvement of central nervous system (CNS) vessels. CNS vasculitis may be primary, in which only intracranial vessels are involved in the inflammatory process, or secondary to another known disorder with overlapping systemic involvement...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865836/epilepsy-in-gliomas-recent-insights-into-risk-factors-and-molecular-pathways
#53
REVIEW
Roberta Rudà, Francesco Bruno, Alessia Pellerino
PURPOSE OF REVIEW: The purpose of this review is to discuss the molecular pathways governing the development of seizures in glioma patients. RECENT FINDINGS: The intrinsic epileptogenicity of the neuronal component of glioneuronal and neuronal tumors is the most relevant factor for seizure development. The two major molecular alterations behind epileptogenicity are the rat sarcoma virus (RAS)/mitogen-activated protein kinase / extracellular signal-regulated kinase (MAPK/ERK) and phosphatidylinositol-3-kinase / protein kinase B / mammalian target of rapamycin (P13K/AKT/mTOR) pathways...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865827/primary-central-nervous-system-vasculitis-and-headache-ten-themes
#54
REVIEW
David S Younger
PURPOSE OF REVIEW: The primary central nervous system (CNS) vasculitides refers to clinicopathologic disorders that share the histopathology of inflammation of cerebral or spinal blood vessels. Unrecognized and therefore untreated, vasculitis of the CNS results in irreversible injury and disability making these disorders of paramount importance to clinicians. RECENT FINDINGS: Headache is an important clue to vasculitic involvement of CNS vessels. CNS vasculitis can be primary, in which only intracranial or spinal vessels are involved in the inflammatory process, or secondary to another known disorder with overlapping systemic involvement...
December 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/38018799/what-visuospatial-perception-has-taught-us-about-the-pathophysiology-of-vestibular-migraine
#55
JOURNAL ARTICLE
Qadeer Arshad, David Moreno-Ajona, Peter J Goadsby, Amir Kheradmand
PURPOSE OF REVIEW: : A decade has passed since vestibular migraine (VM) was formally established as a clinical entity. During this time, VM has emerged amongst the most common cause of episodic vertigo. Like all forms of migraine, VM symptoms are most prominent during individual attacks, however many patients may also develop persistent symptoms that are less prominent and can still interfere with daily activities. RECENT FINDINGS: Vestibular inputs are strongly multimodal, and because of extensive convergence with other sensory information, they do not result in a distinct conscious sensation...
November 30, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37889571/electrical-stimulation-of-the-peripheral-and-central-vestibular-system
#56
JOURNAL ARTICLE
Christophe Lopez, Kathleen E Cullen
PURPOSE OF REVIEW: Electrical stimulation of the peripheral and central vestibular system using noninvasive (galvanic vestibular stimulation, GVS) or invasive (intracranial electrical brain stimulation, iEBS) approaches have a long history of use in studying self-motion perception and balance control. The aim of this review is to summarize recent electrophysiological studies of the effects of GVS, and functional mapping of the central vestibular system using iEBS in awake patients. RECENT FINDINGS: The use of GVS has become increasingly common in the assessment and treatment of a wide range of clinical disorders including vestibulopathy and Parkinson's disease...
October 26, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865841/covid-19-related-headaches-epidemiology-pathophysiology-impacts-and-management
#57
JOURNAL ARTICLE
Olalekan Lee Aiyegbusi
PURPOSE OF REVIEW: This is an expert overview of the recent literature on the nature, epidemiology, pathophysiology, impact, and management of COVID-19 related headache, in the acute phase of infection and in post-COVID-19 syndrome. RECENT FINDINGS: Headache is one of the commonest symptoms of COVID-19 during acute infection and it is often experienced by individuals who go on to develop long COVID. There is a higher prevalence of headache in individuals with long COVID who contracted the Delta variant than in those who were infected with the Wuhan or Alpha variants...
October 4, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37865833/remote-ischemic-conditioning-as-an-emerging-tool-to-improve-corticospinal-transmission-in-individuals-with-chronic-spinal-cord-injury
#58
JOURNAL ARTICLE
Yu-Kuang Wu, Jill M Wecht, Ona E Bloom, Gino S Panza, Noam Y Harel
PURPOSE OF REVIEW: Remote ischemic conditioning (RIC) involves transient blood flow restriction to one limb leading to systemic tissue-protective effects. RIC shares some potential underlying mechanisms with intermittent hypoxia (IH), in which brief bouts of systemic hypoxia trigger increases in growth factor expression and neural plasticity. RIC has shown promise in acute myocardial infarction and stroke but may be applicable toward chronic neuropathology as well. Consequently, this review discusses similarities and differences between RIC and IH and presents preliminary and ongoing research findings regarding RIC...
October 2, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37678340/degenerative-and-cognitive-diseases
#59
JOURNAL ARTICLE
Rosie E Curiel Cid
No abstract text is available yet for this article.
October 1, 2023: Current Opinion in Neurology
https://read.qxmd.com/read/37678339/therapeutic-developments-for-valosin-containing-protein-mediated-multisystem-proteinopathy
#60
REVIEW
Victoria Boock, Bhaskar Roy, Gerald Pfeffer, Virginia Kimonis
PURPOSE OF REVIEW: Missense mutations in valosin-containing protein (VCP) can lead to a multisystem proteinopathy 1 (MSP1) with any combination of limb-girdle distribution inclusion body myopathy (IBM) (present in about 90% of cases), Paget's disease of bone, and frontotemporal dementia (IBMPFD). VCP mutations lead to gain of function activity with widespread disarray in cellular function, with enhanced ATPase activity, increased binding with its cofactors, and reduced mitofusin levels...
October 1, 2023: Current Opinion in Neurology
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