Chinh D Nguyen, Haustine P Panganiban, Timothy Fazio, Amalia Karahalios, Melissa Akravs, Christopher M MacIsaac, Thomas Rechnitzer, Lucy Arno, An Tran-Duy, Scott McAlister, Yasmine Ali Abdelhamid, Adam M Deane
OBJECTIVES: Hypophosphatemia occurs frequently. Enteral, rather than IV, phosphate replacement may reduce fluid replacement, cost, and waste. DESIGN: Prospective, randomized, parallel group, noninferiority clinical trial. SETTING: Single center, 42-bed state trauma, medical and surgical ICUs, from April 20, 2022, to July 1, 2022. PATIENTS: Patients with serum phosphate concentration between 0.3 and 0.75 mmol/L. INTERVENTIONS: We randomized patients to either enteral or IV phosphate replacement using electronic medical record-embedded program...
March 25, 2024: Critical Care Medicine
Maniraj Neupane, Nathaniel De Jonge, Sahil Angelo, Sadia Sarzynski, Junfeng Sun, Bram Rochwerg, John Hick, Steven H Mitchell, Sarah Warner, Alex Mancera, Diane Cooper, Sameer S Kadri
OBJECTIVES: COVID-19 pandemic surges strained hospitals globally. We performed a systematic review to examine measures of pandemic caseload surge and its impact on mortality of hospitalized patients. DATA SOURCES: PubMed, Embase, and Web of Science. STUDY SELECTION: English-language studies published between December 1, 2019, and November 22, 2023, which reported the association between pandemic "surge"-related measures and mortality in hospitalized patients...
March 22, 2024: Critical Care Medicine
Emily J See, Anis Chaba, Sofia Spano, Akinori Maeda, Caroline Clapham, Louise M Burrell, Jasmine Liu, Monique Khasin, Grace Liskaser, Glenn Eastwood, Rinaldo Bellomo
OBJECTIVES: The relationship between renin levels, exposure to renin-angiotensin system (RAS) inhibitors, angiotensin II (ANGII) responsiveness, and outcome in patients with vasopressor-dependent vasodilatory hypotension is unknown. DESIGN: We conducted a single-center prospective observational study to explore whether recent RAS inhibitor exposure affected baseline renin levels, whether baseline renin levels predicted ANGII responsiveness, and whether renin levels at 24 hours were associated with clinical outcomes...
March 21, 2024: Critical Care Medicine
Peter J Dunbar, Ryan Peterson, Max McGrath, Raymond Pomponio, Tyree H Kiser, P Michael Ho, R William Vandivier, Ellen L Burnham, Marc Moss, Peter D Sottile
OBJECTIVES: To describe U.S. practice regarding administration of sedation and analgesia to patients on noninvasive ventilation (NIV) for acute respiratory failure (ARF) and to determine the association of this practice with odds of intubation or death. DESIGN: A retrospective multicenter cohort study. SETTING: A total of 1017 hospitals contributed data between January 2010 and September 2020 to the Premier Healthcare Database, a nationally representative healthcare database in the United States...
March 20, 2024: Critical Care Medicine
Megan E Feeney, Anica C Law, Allan J Walkey, Nicholas A Bosch
OBJECTIVES: To describe practice patterns surrounding the use of medications to treat opioid use disorder (MOUD) in critically ill patients. DESIGN: Retrospective, multicenter, observational study using the Premier AI Healthcare Database. SETTING: The study was conducted in U.S. ICUs. PATIENTS: Adult (≥ 18 yr old) patients with a history of opioid use disorder (OUD) admitted to an ICU between 2016 and 2020. INTERVENTIONS: None...
March 19, 2024: Critical Care Medicine
Kateřina Jiroutková, František Duška, Petr Waldauf
OBJECTIVES: We published a meta-analysis in March 2020 to assess the impact of rehabilitation in the ICU on clinical outcomes. Since then, 15 new randomized controlled trials (RCTs) have been published; we updated the meta-analysis to show how the recent studies have tipped the scale. DESIGN: Systematic review and meta-analysis. SETTING: An update of secondary data analysis of RCTs published between January 1998 and July 2023 performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
March 19, 2024: Critical Care Medicine
Faheem W Guirgis, Lauren Page Black, Morgan Henson, Andrew Bertrand, Elizabeth DeVos, Jason Ferreira, Hanzhi Gao, Samuel S Wu, Christiaan Leeuwenburgh, Lyle Moldawer, Frederick Moore, Srinivasa T Reddy
OBJECTIVES: Low cholesterol levels in early sepsis patients are associated with mortality. We sought to test if IV lipid emulsion administration to sepsis patients with low cholesterol levels would prevent a decline or increase total cholesterol levels at 48 hours. DESIGN: Phase II, adaptive, randomized pilot clinical trial powered for 48 patients. SETTING: Emergency department or ICU of an academic medical center. PATIENTS: Sepsis patients (first 24 hr) with Sequential Organ Failure Assessment greater than or equal to 4 or shock...
March 15, 2024: Critical Care Medicine
Daniel S Harrison, Erika J Sigman, Judy H Ch'ang, Aarti Sarwal, Abigale Celotto, Alexandra Malone, Ariel Nowicki, Ashley Martin, Bryan Boling, Christa O'Hana S Nobleza, Christopher Reeves, David M Greer, Diane McLaughlin, Elizabeth O'B Woods, Emmaculate Fields, Erica Perets, Gemi E Jannotta, Jennifer Mears, Kaitlyn Twomey, Kelly A Rath, Kelly Peronti, Krista M Garner, Matthew B Bevers, Nicholas A Morris, Paola Martinez, Sahar Zafar, Sarah Livesay, Sarah Wahlster, Thomas Lawson, Catherine S W Albin
OBJECTIVES: To define consensus entrustable professional activities (EPAs) for neurocritical care (NCC) advanced practice providers (APPs), establish validity evidence for the EPAs, and evaluate factors that inform entrustment expectations of NCC APP supervisors. DESIGN: A three-round modified Delphi consensus process followed by application of the EQual rubric and assessment of generalizability by clinicians not affiliated with academic medical centers. SETTING: Electronic surveys...
March 15, 2024: Critical Care Medicine
Kallirroi Laiya Carayannopoulos, Fayez Alshamsi, Dipayan Chaudhuri, Laura Spatafora, Joshua Piticaru, Kaitryn Campbell, Waleed Alhazzani, Kimberley Lewis
OBJECTIVES: To conduct a systematic review and meta-analysis assessing whether the use of antipsychotic medications in critically ill adult patients with delirium impacts patient-important outcomes. DATA SOURCES: A medical librarian searched Ovid MEDLINE, EMBASE, APA PsycInfo, and Wiley's Cochrane Library as well as and the World Health Organization International Clinical Trials Registry Platform up to November 2023. STUDY SELECTION: Independently and in duplicate, reviewers screened abstracts and titles for eligibility, then full text of qualifying studies...
March 15, 2024: Critical Care Medicine
Rafael Wabl
No abstract text is available yet for this article.
March 15, 2024: Critical Care Medicine
Katrina M Morgan, Elissa Abou Khalil, Erin V Feeney, Philip C Spinella, Amelia C Lucisano, Barbara A Gaines, Christine M Leeper
OBJECTIVES: To assess if transfusion with low-titer group O whole blood (LTOWB) is associated with improved early and/or late survival compared with component blood product therapy (CT) in bleeding trauma patients. DATA SOURCES: A systematic search of PubMed, CINAHL, and Web of Science was performed from their inception through December 1, 2023. Key terms included injury, hemorrhage, bleeding, blood transfusion, and whole blood. STUDY SELECTION: All studies comparing outcomes in injured civilian adults and children who received LTOWB versus CT were included...
March 14, 2024: Critical Care Medicine
Clement Gakuba, Charlene Le Barbey, Alexandre Sar, Gregory Bonnet, Damiano Cerasuolo, Mikhael Giabicani, Jean-Denis Moyer
OBJECTIVES: To evaluate the capacity of ChatGPT, a widely accessible and uniquely popular artificial intelligence-based chatbot, in predicting the 6-month outcome following moderate-to-severe traumatic brain injury (TBI). DESIGN: Single-center observational retrospective study. SETTING: Data are from a neuro-ICU from a level 1 trauma center. PATIENTS: All TBI patients admitted to ICU between September 2021 and October 2022 were included in a prospective database...
March 6, 2024: Critical Care Medicine
Yuan Bian, Yuhui Pan, Jiaqi Zheng, Wen Zheng, Lijie Qin, Guangju Zhou, Xifeng Sun, Mingjie Wang, Chunyi Wang, Yuguo Chen, Feng Xu
OBJECTIVE: Comparing the effects of extracorporeal cardiopulmonary resuscitation (ECPR) and conventional cardiopulmonary resuscitation (CCPR) on outcomes in patients with in-hospital cardiac arrest (IHCA) in China. The benefits of ECPR over CCPR in patients with IHCA remain controversial. DESIGN: This article analyzed data from the BASeline Investigation of In-hospital Cardiac Arrest (BASIC-IHCA) study, which consecutively enrolled patients with IHCA from July 1, 2019, to December 31, 2020...
March 5, 2024: Critical Care Medicine
Momoko Sugimoto, Wataru Takayama, Akihiko Inoue, Toru Hifumi, Tetsuya Sakamoto, Yasuhiro Kuroda, Yasuhiro Otomo
OBJECTIVES: Serial evaluations of lactate concentration may be more useful in predicting outcomes in patients with out-of-hospital cardiac arrest (OHCA) than a single measurement. This study aimed to evaluate the impact of lactate clearance (LC) on clinical and neurologic outcomes in patients with OHCA who underwent extracorporeal cardiopulmonary resuscitation (ECPR). DESIGN: Retrospective multicenter observational study. SETTING: Patients with OHCA receiving ECPR at 36 hospitals in Japan between January 1, 2013, and December 31, 2018...
February 27, 2024: Critical Care Medicine
Todd A Miano, Erin F Barreto, Molly McNett, Niels Martin, Ankit Sakhuja, Adair Andrews, Rajit K Basu, Enyo Ama Ablordeppey
OBJECTIVES: Accurate glomerular filtration rate (GFR) assessment is essential in critically ill patients. GFR is often estimated using creatinine-based equations, which require surrogates for muscle mass such as age and sex. Race has also been included in GFR equations, based on the assumption that Black individuals have genetically determined higher muscle mass. However, race-based GFR estimation has been questioned with the recognition that race is a poor surrogate for genetic ancestry, and racial health disparities are driven largely by socioeconomic factors...
February 26, 2024: Critical Care Medicine
Athanasios Chalkias, Yiyuan Huang, Anis Ismail, Ioannis Pantazopoulos, Nikolaos Papagiannakis, Brayden Bitterman, Elizabeth Anderson, Tonimarie Catalan, Grace K Erne, Caroline R Tilley, Abiola Alaka, Kingsley M Amadi, Feriel Presswalla, Pennelope Blakely, Enrique Bernal-Morell, Iria Cebreiros López, Jesper Eugen-Olsen, Luis García de Guadiana Romualdo, Evangelos J Giamarellos-Bourboulis, Sven H Loosen, Jochen Reiser, Frank Tacke, Anargyros Skoulakis, Eleni Laou, Mousumi Banerjee, Rodica Pop-Busui, Salim S Hayek
OBJECTIVES: To evaluate the impact of intubation timing, guided by severity criteria, on mortality in critically ill COVID-19 patients, amidst existing uncertainties regarding optimal intubation practices. DESIGN: Prospective, multicenter, observational study conducted from February 1, 2020, to November 1, 2022. SETTING: Ten academic institutions in the United States and Europe. PATIENTS: Adults (≥ 18 yr old) confirmed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hospitalized specifically for COVID-19, requiring intubation postadmission...
February 23, 2024: Critical Care Medicine
Stephanie P Taylor, Marc A Kowalkowski, Sable Skewes, Shih-Hsiung Chou
OBJECTIVE: To evaluate real-world implications of updated Surviving Sepsis Campaign (SSC) recommendations for antibiotic timing. DESIGN: Retrospective cohort study. SETTING: Twelve hospitals in the Southeastern United States between 2017 and 2021. PATIENTS: One hundred sixty-six thousand five hundred fifty-nine adult hospitalized patients treated in the emergency department for suspected serious infection. INTERVENTIONS: None...
February 22, 2024: Critical Care Medicine
Matthew A Levin, Arash Kia, Prem Timsina, Fu-Yuan Cheng, Kim-Anh-Nhi Nguyen, Roopa Kohli-Seth, Hung-Mo Lin, Yuxia Ouyang, Robert Freeman, David L Reich
OBJECTIVES: Machine learning algorithms can outperform older methods in predicting clinical deterioration, but rigorous prospective data on their real-world efficacy are limited. We hypothesized that real-time machine learning generated alerts sent directly to front-line providers would reduce escalations. DESIGN: Single-center prospective pragmatic nonrandomized clustered clinical trial. SETTING: Academic tertiary care medical center. PATIENTS: Adult patients admitted to four medical-surgical units...
February 21, 2024: Critical Care Medicine
Lauren M Janczewski, Adithya Chandrasekaran, Egide Abahuje, Bona Ko, John D Slocum, Kaithlyn Tesorero, My L T Nguyen, Sohae Yang, Erin A Strong, Kunjan Bhakta, Jeffrey P Huml, Jacqueline M Kruser, Julie K Johnson, Anne M Stey
OBJECTIVES: To understand frontline ICU clinician's perceptions of end-of-life care delivery in the ICU. DESIGN: Qualitative observational cross-sectional study. SETTING: Seven ICUs across three hospitals in an integrated academic health system. SUBJECTS: ICU clinicians (physicians [critical care, palliative care], advanced practice providers, nurses, social workers, chaplains). INTERVENTIONS: None...
February 19, 2024: Critical Care Medicine
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.