journal
https://read.qxmd.com/read/38380992/real-time-machine-learning-alerts-to-prevent-escalation-of-care-a-nonrandomized-clustered-pragmatic-clinical-trial
#21
JOURNAL ARTICLE
Matthew A Levin, Arash Kia, Prem Timsina, Fu-Yuan Cheng, Kim-Anh-Nhi Nguyen, Roopa Kohli-Seth, Hung-Mo Lin, Yuxia Ouyang, Robert Freeman, David L Reich
OBJECTIVES: Machine learning algorithms can outperform older methods in predicting clinical deterioration, but rigorous prospective data on their real-world efficacy are limited. We hypothesized that real-time machine learning generated alerts sent directly to front-line providers would reduce escalations. DESIGN: Single-center prospective pragmatic nonrandomized clustered clinical trial. SETTING: Academic tertiary care medical center. PATIENTS: Adult patients admitted to four medical-surgical units...
February 21, 2024: Critical Care Medicine
https://read.qxmd.com/read/38372629/barriers-and-facilitators-to-end-of-life-care-delivery-in-icus-a-qualitative-study
#22
JOURNAL ARTICLE
Lauren M Janczewski, Adithya Chandrasekaran, Egide Abahuje, Bona Ko, John D Slocum, Kaithlyn Tesorero, My L T Nguyen, Sohae Yang, Erin A Strong, Kunjan Bhakta, Jeffrey P Huml, Jacqueline M Kruser, Julie K Johnson, Anne M Stey
OBJECTIVES: To understand frontline ICU clinician's perceptions of end-of-life care delivery in the ICU. DESIGN: Qualitative observational cross-sectional study. SETTING: Seven ICUs across three hospitals in an integrated academic health system. SUBJECTS: ICU clinicians (physicians [critical care, palliative care], advanced practice providers, nurses, social workers, chaplains). INTERVENTIONS: None...
February 19, 2024: Critical Care Medicine
https://read.qxmd.com/read/38363176/comparison-of-different-treatments-of-persistent-pulmonary-hypertension-of-the-newborn-a-systematic-review-and-network-meta-analysis
#23
JOURNAL ARTICLE
Qiang Fei, Jiarong Pan, Feizhou Zhang, Yu Lin, Tianming Yuan
OBJECTIVES: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening disease. Despite being considered the gold standard treatment scheme, inhaled nitric oxide (iNO) is not readily available in settings with limited resources. Therefore, in recent years, research on related drugs is being actively pursued. Herein, we aimed to use random-effects network meta-analysis to evaluate the efficacy and associated mortality of different PPHN therapies. DATA SOURCES: We electronically searched the PubMed, Embase, and Cochrane Library for data up to January 27, 2023...
February 16, 2024: Critical Care Medicine
https://read.qxmd.com/read/38358303/evolution-of-clinical-characteristics-and-outcomes-of-critically-ill-patients-90-years-old-or-older-over-a-12-year-period-a-retrospective-cohort-study
#24
JOURNAL ARTICLE
Rikus Daniels, Jakob Müller, Claudia Jafari, Pauline Theile, Stefan Kluge, Kevin Roedl
OBJECTIVES: The global population is aging, and the proportion of very elderly patients 90 years old or older in the ICU is expected to increase. The changes in the comorbidities and outcomes of very elderly patients hospitalized in the ICU that have occurred over time are unknown. DESIGN: Retrospective observational cohort study. SETTING: ICUs at a single academic hospital in Germany. PATIENTS: Ninety years old or older and admitted to the ICU between January 1, 2008, and April 30, 2019...
February 15, 2024: Critical Care Medicine
https://read.qxmd.com/read/38353592/fixed-versus-variable-dose-prothrombin-complex-concentrate-for-the-emergent-reversal-of-vitamin-k-antagonists-a-systematic-review-and-meta-analysis
#25
JOURNAL ARTICLE
Amr Alwakeal, Matthew B Maas, Andrew M Naidech, Babak S Jahromi, Matthew B Potts
OBJECTIVES: Four-factor prothrombin complex concentrate (4-PCC) is recommended for rapid reversal of vitamin K antagonists (VKAs) such as warfarin, yet optimal dosing remains uncertain. DATA SOURCES: A systematic review was conducted of PubMed, Embase, and Ovid MEDLINE (Wolters Kluwer) databases from January 2000 to August 2023 for clinical studies comparing fixed- vs. variable-dose 4-PCC for emergent VKA reversal with at least one reported clinical outcome. STUDY SELECTION: Abstracts and full texts were assessed independently and in duplicate by two reviewers...
February 14, 2024: Critical Care Medicine
https://read.qxmd.com/read/38345418/factors-affecting-mortality-in-critically-ill-patients-with-tuberculosis-a-systematic-review-and-meta-analysis
#26
JOURNAL ARTICLE
Shivangi Mishra, Jinay Gala, Jose Chacko
OBJECTIVES: Critically ill patients with tuberculosis carry high mortality. Identification of factors associated with mortality in critically ill tuberculosis patients may enable focused treatment. DATA SOURCES: An extensive literature search of PubMed (MEDLINE), Embase, the Cochrane Library, and Google Scholar was performed using Medical Subject Headings terms "tuberculosis," "critical care," "critical care outcome," and "ICU." We aimed to identify factors affecting mortality in critically ill tuberculosis patients...
February 12, 2024: Critical Care Medicine
https://read.qxmd.com/read/38334448/current-use-and-impact-of-pulmonary-artery-catheters-on-the-short-term-outcomes-in-patients-with-cardiogenic-shock-treated-with-an-impella-findings-from-the-japan-registry-for-percutaneous-ventricular-assist-device-j-pvad
#27
JOURNAL ARTICLE
Riku Arai, Nobuhiro Murata, Daisuke Fukamachi, Yasuo Okumura
OBJECTIVES: This study aimed to investigate the current use and impact of pulmonary artery catheters (PACs) in patients with cardiogenic shock (CS) who underwent Impella support. DESIGN: This was a prospective multicenter observational study between January 2020 and December 2021 that registered all patients with drug-refractory acute heart failure and in whom the placement of an Impella 2.5, CP, or 5.0 pump was attempted or successful in Japan. SETTING: Cardiac ICUs in Japan...
February 9, 2024: Critical Care Medicine
https://read.qxmd.com/read/38502807/the-effect-of-albumin-administration-in-critically-ill-patients-a-retrospective-single-center-analysis
#28
JOURNAL ARTICLE
Salim Abdelhamid, Rita Achermann, Alexa Hollinger, Madlaina Hauser, Maren Trutmann, Laura Gallacchi, Martin Siegemund
OBJECTIVES: The aim of this study was to analyze the development of albumin administration in patients admitted to the adult ICU. In addition, we assessed the impact of albumin administration on serum hemoglobin concentration. DESIGN: We conducted a retrospective single-center study including all patients who were admitted to the ICU from January 2013 to December 2021 and stayed at least 24 hours. SETTING: The study was conducted in an academic hospital (University Hospital Basel, Switzerland)...
February 7, 2024: Critical Care Medicine
https://read.qxmd.com/read/38502804/biomarkers-improve-diagnostics-of-sepsis-in-adult-patients-with-suspected-organ-dysfunction-based-on-the-quick-sepsis-related-organ-failure-assessment-qsofa-score-in-the-emergency-department
#29
JOURNAL ARTICLE
Myrto Bolanaki, Johannes Winning, Anna Slagman, Thomas Lehmann, Michael Kiehntopf, Angelika Stacke, Caroline Neumann, Konrad Reinhart, Martin Möckel, Michael Bauer
OBJECTIVES: Consensus regarding biomarkers for detection of infection-related organ dysfunction in the emergency department is lacking. We aimed to identify and validate biomarkers that could improve risk prediction for overt or incipient organ dysfunction when added to quick Sepsis-related Organ Failure Assessment (qSOFA) as a screening tool. DESIGN: In a large prospective multicenter cohort of adult patients presenting to the emergency department with a qSOFA score greater than or equal to 1, admission plasma levels of C-reactive protein, procalcitonin, adrenomedullin (either bioavailable adrenomedullin or midregional fragment of proadrenomedullin), proenkephalin, and dipeptidyl peptidase 3 were assessed...
February 7, 2024: Critical Care Medicine
https://read.qxmd.com/read/38502800/hospital-variation-in-epinephrine-administration-before-defibrillation-for-cardiac-arrest-due-to-shockable-rhythm
#30
JOURNAL ARTICLE
Colten Stewart, Paul S Chan, Kevin Kennedy, Morgan B Swanson, Saket Girotra
OBJECTIVES: Contrary to advanced cardiac life support guidelines that recommend immediate defibrillation for shockable in-hospital cardiac arrest (IHCA), epinephrine administration before first defibrillation is common and associated with lower survival at a "patient-level." Whether this practice varies across hospitals and its association with "hospital-level" IHCA survival remains unknown. The purpose of this study was to determine hospital variation in rates of epinephrine administration before defibrillation for shockable IHCA and its association with IHCA survival...
February 7, 2024: Critical Care Medicine
https://read.qxmd.com/read/38317369/early-mobilization-using-a-mobile-patient-lift-in-the-icu-a-randomized-controlled-trial
#31
JOURNAL ARTICLE
Ginga Suzuki, Hiromi Kanayama, Yoshiaki Arai, Yuji Iwanami, Toshimitsu Kobori, Yuka Masuyama, Saki Yamamoto, Hibiki Serizawa, Yoshimi Nakamichi, Masayuki Watanabe, Mitsuru Honda, Ikuko Okuni
OBJECTIVES: To ascertain whether a mobile patient lift facilitates early mobilization in ventilated ICU patients. DESIGN: A single-center, open-label, randomized controlled trial. SETTING: An academic ICU in Tokyo. PATIENTS: Eighty patients were admitted to ICU and expected ventilation for at least 48 hours. INTERVENTIONS: In the intervention group, in addition to the rehabilitation protocol received by the control group, patients were assisted in sitting, standing, transfers, and walking using the mobile patient lift...
February 6, 2024: Critical Care Medicine
https://read.qxmd.com/read/38299970/effect-of-increasing-blood-pressure-on-brain-tissue-oxygenation-in-adults-after-severe-traumatic-brain-injury
#32
JOURNAL ARTICLE
Thitikan Kunapaisal, Abhijit V Lele, Courtney Gomez, Anne Moore, Marie Angele Theard, Monica S Vavilala
OBJECTIVES: To examine if increasing blood pressure improves brain tissue oxygenation (PbtO2) in adults with severe traumatic brain injury (TBI). DESIGN: Retrospective review of prospectively collected data. SETTING: Level-I trauma center teaching hospital. PATIENTS: Included patients greater than or equal to 18 years of age and with severe (admission Glasgow Coma Scale [GCS] score < 9) TBI who had advanced neuromonitoring (intracranial blood pressure [ICP], PbtO2, and cerebral autoregulation testing)...
February 1, 2024: Critical Care Medicine
https://read.qxmd.com/read/38299933/associations-between-family-assessed-quality-of-dying-and-death-latent-classes-and-bereavement-outcomes-for-family-surrogates-of-icu-decedents
#33
JOURNAL ARTICLE
Fur-Hsing Wen, Holly G Prigerson, Tsung-Hui Hu, Chung-Chi Huang, Wen-Chi Chou, Li-Pang Chuang, Ming Chu Chiang, Siew Tzuh Tang
OBJECTIVES: To examine associations between family surrogates' bereavement outcomes and four previously determined quality of dying and death (QODD) latent classes (high, moderate, poor-to-uncertain, and worst). DESIGN: Prospective, longitudinal, observational study. SETTING: Medical ICUs at two academically affiliated medical centers in Taiwan. PATIENTS/PARTICIPANTS: Three hundred nine family surrogates responsible for decision-making for critically ill patients at high risk of death (Acute Physiology and Chronic Health Evaluation II scores > 20) from a disease...
February 1, 2024: Critical Care Medicine
https://read.qxmd.com/read/38277179/effects-of-vibration-therapy-on-the-physical-function-of-critically-ill-adults-trial-a-randomized-controlled-trial
#34
JOURNAL ARTICLE
Satoshi Doi, Nobuto Nakanishi, Yoshimi Kawahara, Keiko Nomura, Mamiko Shima, Mie Shiraishi, Jun Oto
OBJECTIVES: Vibration therapy uses vibration to rehabilitate physical functions. Recently, it has been demonstrated to be safe for critically ill patients. However, its effects on physical functions are unclear. DESIGN: Randomized controlled trial. SETTING: A single-center, ICU. PATIENTS: Patients were randomly assigned to either vibration therapy coupled with protocolized mobilization or protocolized mobilization alone...
January 26, 2024: Critical Care Medicine
https://read.qxmd.com/read/38265271/treatment-fidelity-in-94-randomized-controlled-trials-of-physical-rehabilitation-in-the-icu-a-scoping-review
#35
JOURNAL ARTICLE
Christopher Farley, Anastasia N L Newman, Jen Hoogenes, Dina Brooks, Mark Duffett, Michelle E Kho
OBJECTIVES: Recent reviews demonstrated discordant effects of ICU-based physical rehabilitation on physical function. These inconsistencies may be related to differences in treatment fidelity-the extent to which a protocol is delivered as planned. Before evaluating the association of fidelity with outcomes, we must first understand the extent of treatment fidelity reporting in ICU-based physical rehabilitation randomized controlled trials (RCTs). DATA SOURCES: Six electronic databases from inception to December 2022...
January 24, 2024: Critical Care Medicine
https://read.qxmd.com/read/38259143/a-nationwide-prospective-study-of-tracheal-intubation-in-critically-ill-adults-in-spain-management-associated-complications-and-outcomes
#36
JOURNAL ARTICLE
José Garnacho-Montero, Elena Gordillo-Escobar, Josep Trenado, Federico Gordo, Lourdes Fisac, Emilio García-Prieto, Cristina López-Martin, Ana Abella, Juan Ramón Jiménez, José Luis García-Garmendia
OBJECTIVES: Our aims were to explore current intubation practices in Spanish ICUs to determine the incidence and risk factors of peri-intubation complications (primary outcome measure: major adverse events), the rate and factors associated with first-pass success, and their impact on mortality as well as the changes of the intubation procedure observed in the COVID-19 pandemic. DESIGN: Prospective, observational, and cohort study. SETTING: Forty-three Spanish ICU...
January 23, 2024: Critical Care Medicine
https://read.qxmd.com/read/38240492/2024-focused-update-guidelines-on-use-of-corticosteroids-in-sepsis-acute-respiratory-distress-syndrome-and-community-acquired-pneumonia
#37
JOURNAL ARTICLE
Dipayan Chaudhuri, Andrea M Nei, Bram Rochwerg, Robert A Balk, Karim Asehnoune, Rhonda Cadena, Joseph A Carcillo, Ricardo Correa, Katherine Drover, Annette M Esper, Hayley B Gershengorn, Naomi E Hammond, Namita Jayaprakash, Kusum Menon, Lama Nazer, Tyler Pitre, Zaffer A Qasim, James A Russell, Ariel P Santos, Aarti Sarwal, Joanna Spencer-Segal, Nejla Tilouche, Djillali Annane, Stephen M Pastores
RATIONALE: New evidence is available examining the use of corticosteroids in sepsis, acute respiratory distress syndrome (ARDS) and community-acquired pneumonia (CAP), warranting a focused update of the 2017 guideline on critical illness-related corticosteroid insufficiency. OBJECTIVES: To develop evidence-based recommendations for use of corticosteroids in hospitalized adults and children with sepsis, ARDS, and CAP. PANEL DESIGN: The 22-member panel included diverse representation from medicine, including adult and pediatric intensivists, pulmonologists, endocrinologists, nurses, pharmacists, and clinician-methodologists with expertise in developing evidence-based Clinical Practice Guidelines...
January 19, 2024: Critical Care Medicine
https://read.qxmd.com/read/38240490/executive-summary-guidelines-on-use-of-corticosteroids-in-critically-ill-patients-with-sepsis-acute-respiratory-distress-syndrome-and-community-acquired-pneumonia-focused-update-2024
#38
JOURNAL ARTICLE
Dipayan Chaudhuri, Andrea M Nei, Bram Rochwerg, Robert A Balk, Karim Asehnoune, Rhonda S Cadena, Joseph A Carcillo, Ricardo Correa, Katherine Drover, Annette M Esper, Hayley B Gershengorn, Naomi E Hammond, Namita Jayaprakash, Kusum Menon, Lama Nazer, Tyler Pitre, Zaffer A Qasim, James A Russell, Ariel P Santos, Aarti Sarwal, Joanna Spencer-Segal, Nejla Tilouche, Djillali Annane, Stephen M Pastores
No abstract text is available yet for this article.
January 19, 2024: Critical Care Medicine
https://read.qxmd.com/read/38240487/management-of-heat-related-illness-and-injury-in-the-intensive-care-unit-a-concise-definitive-review
#39
JOURNAL ARTICLE
Jeffrey F Barletta, Tina L Palmieri, Shari A Toomey, Christopher G Harrod, Srinivas Murthy, Heatherlee Bailey
OBJECTIVES: The increasing frequency of extreme heat events has led to a growing number of heat-related injuries and illnesses in ICUs. The objective of this review was to summarize and critically appraise evidence for the management of heat-related illnesses and injuries for critical care multiprofessionals. DATA SOURCES: Ovid Medline, Embase, Cochrane Clinical Trials Register, Cumulative Index to Nursing and Allied Health Literature, and ClinicalTrials.gov databases were searched from inception through August 2023 for studies reporting on heat-related injury and illness in the setting of the ICU...
January 19, 2024: Critical Care Medicine
https://read.qxmd.com/read/38240484/society-of-critical-care-medicine-guidelines-on-glycemic-control-for-critically-ill-children-and-adults-2024
#40
JOURNAL ARTICLE
Kimia Honarmand, Michael Sirimaturos, Eliotte L Hirshberg, Nicholas G Bircher, Michael S D Agus, David L Carpenter, Claudia R Downs, Elizabeth A Farrington, Amado X Freire, Amanda Grow, Sharon Y Irving, James S Krinsley, Michael J Lanspa, Micah T Long, David Nagpal, Jean-Charles Preiser, Vijay Srinivasan, Guillermo E Umpierrez, Judith Jacobi
RATIONALE: Maintaining glycemic control of critically ill patients may impact outcomes such as survival, infection, and neuromuscular recovery, but there is equipoise on the target blood levels, monitoring frequency, and methods. OBJECTIVES: The purpose was to update the 2012 Society of Critical Care Medicine and American College of Critical Care Medicine (ACCM) guidelines with a new systematic review of the literature and provide actionable guidance for clinicians...
April 1, 2024: Critical Care Medicine
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