David Granton, Dipayan Chaudhuri, Dominic Wang, Sharon Einav, Yigal Helviz, Tommaso Mauri, Jordi Mancebo, Jean-Pierre Frat, Sameer Jog, Gonzalo Hernandez, Salvatore M Maggiore, Carol L Hodgson, Samir Jaber, Laurent Brochard, Vatsal Trivedi, Jean-Damien Ricard, Ewan C Goligher, Karen E A Burns, Bram Rochwerg
OBJECTIVES: Reintubation after failed extubation is associated with increased mortality and longer hospital length of stay. Noninvasive oxygenation modalities may prevent reintubation. We conducted a systematic review and meta-analysis to determine the safety and efficacy of high-flow nasal cannula after extubation in critically ill adults. DATA SOURCES: We searched MEDLINE, EMBASE, and Web of Science. STUDY SELECTION: We included randomized controlled trials comparing high-flow nasal cannula to other noninvasive methods of oxygen delivery after extubation in critically ill adults...
September 18, 2020: Critical Care Medicine
Cornelia Knaak, Friederike S Schuster, Peter Nyvlt, Claudia Spies, Insa Feinkohl, Gernot Beutel, Thomas Schenk, Paul La Rosée, Gritta Janka, Frank M Brunkhorst, Didier Keh, Gunnar Lachmann
OBJECTIVES: Hemophagocytic lymphohistiocytosis is a cytokine release syndrome caused by uncontrolled immune activation resulting in multiple organ failure and death. In this systematic review, we aimed to analyze triggers, various treatment modalities, and mortality in critically ill adult hemophagocytic lymphohistiocytosis patients. DATA SOURCES: MEDLINE database (PubMed) at October 20, 2019. STUDY SELECTION: Studies and case series of patients greater than or equal to 18 years old, of whom at least one had to be diagnosed with hemophagocytic lymphohistiocytosis and admitted to an ICU...
September 18, 2020: Critical Care Medicine
Jenna K Lang, Melanie S Paykel, Kimberley J Haines, Carol L Hodgson
OBJECTIVES: To evaluate the methodological quality and thematic completeness of existing clinical practice guidelines, addressing early mobilization of adults in the ICU. DATA SOURCES: Systematic review of Medline, Embase, CINAHL, Cochrane, and grey literature from January 2008 to February 2020. STUDY SELECTION: Two reviewers independently screened titles and abstracts and then full texts for eligibility. Ten publications were included. DATA EXTRACTION: A single reviewer extracted data from the included publications and a second reviewer completed cross-checking...
September 18, 2020: Critical Care Medicine
Suchitra Ranjit, Rajeswari Natraj, Niranjan Kissoon, Ravi Thiagarajan, Balakrishnan Ramakrishnan, M Ignacio Monge García
BACKGROUND: Fluid boluses aiming to improve the cardiac output and oxygen delivery are commonly administered in children with shock. An increased mean arterial pressure in addition to resolution of tachycardia and improved peripheral perfusion are often monitored as clinical surrogates for improvement in cardiac output. The objective of our study is to describe changes in cardiac index, mean arterial pressure, and their relationship to other indices of cardiovascular performance. OBJECTIVE: The objective of our study is to describe changes in cardiac index, mean arterial pressure, and their relationship to other indices of cardiovascular performance...
September 18, 2020: Critical Care Medicine
Andrew Sumarsono, Jiexin Wang, Luyu Xie, Giuliana Cerro Chiang, Thomas Tielleman, Sarah E Messiah, Amit G Singal, Arjmand Mufti, Catherine Chen, Matthew Leveno
OBJECTIVES: Cirrhosis is frequently complicated by electrolyte disturbances, with prior studies primarily focused on the importance of hyponatremia. Emerging evidence on patients with chronic heart failure and chronic kidney disease has identified hypochloremia as an independent predictor for mortality. This study aimed to investigate the prognostic value of serum chloride and its association with mortality in cirrhotic patients. DESIGN: Retrospective cohort study...
September 18, 2020: Critical Care Medicine
Mark E Mikkelsen, Mary Still, Brian J Anderson, O Joseph Bienvenu, Martin B Brodsky, Nathan Brummel, Brad Butcher, Alison S Clay, Hali Felt, Lauren E Ferrante, Kimberley J Haines, Michael O Harhay, Aluko A Hope, Ramona O Hopkins, Megan Hosey, Catherine Terri L Hough, James C Jackson, Annie Johnson, Babar Khan, Nazir I Lone, Pamela MacTavish, Joanne McPeake, Ashley Montgomery-Yates, Dale M Needham, Giora Netzer, Christa Schorr, Becky Skidmore, Joanna L Stollings, Reba Umberger, Adair Andrews, Theodore J Iwashyna, Carla M Sevin
BACKGROUND: After critical illness, new or worsening impairments in physical, cognitive, and/or mental health function are common among patients who have survived. Who should be screened for long-term impairments, what tools to use, and when remain unclear. OBJECTIVES: Provide pragmatic recommendations to clinicians caring for adult survivors of critical illness related to screening for postdischarge impairments. PARTICIPANTS: Thirty-one international experts in risk-stratification and assessment of survivors of critical illness, including practitioners involved in the Society of Critical Care Medicine's Thrive Post-ICU Collaboratives, survivors of critical illness, and clinical researchers...
September 18, 2020: Critical Care Medicine
Byeong Tak Lee, O-Yeon Kwon, Hyunho Park, Kyung-Jae Cho, Joon-Myoung Kwon, Yeha Lee
OBJECTIVES: A deep learning-based early warning system is proposed to predict sepsis prior to its onset. DESIGN: A novel algorithm was devised to detect sepsis 6 hours prior to its onset based on electronic medical records. SETTING: Retrospective cohorts from three separate hospitals are used in this study. Sepsis onset was defined based on Sepsis-3. Algorithms are evaluated based on the score function used in the Physionet Challenge 2019...
September 18, 2020: Critical Care Medicine
Matthew F Mart, E Wesley Ely
No abstract text is available yet for this article.
September 17, 2020: Critical Care Medicine
Sivasubramanium V Bhavani, Krysta S Wolfe, Cara L Hrusch, Jared A Greenberg, Paulette A Krishack, Julie Lin, Paola Lecompte-Osorio, Kyle A Carey, John P Kress, Craig M Coopersmith, Anne I Sperling, Philip A Verhoef, Matthew M Churpek, Bhakti K Patel
OBJECTIVES: We recently found that distinct body temperature trajectories of infected patients correlated with survival. Understanding the relationship between the temperature trajectories and the host immune response to infection could allow us to immunophenotype patients at the bedside using temperature. The objective was to identify whether temperature trajectories have consistent associations with specific cytokine responses in two distinct cohorts of infected patients. DESIGN: Prospective observational study...
September 17, 2020: Critical Care Medicine
Mauro Panigada, Alberto Cucino, Elena Spinelli, Giovanna Occhipinti, Giovanna Panarello, Cristina Novembrino, Dario Consonni, Alessandro Protti, Alfredo Lissoni, Antonio Arcadipane, Antonio Pesenti, Giacomo Grasselli
OBJECTIVES: Supplementation of antithrombin might decrease the amount of heparin needed to achieve a given anticoagulation target during extracorporeal membrane oxygenation. However, exogenous antithrombin itself may increase the risk of bleeding. We conceived a study to evaluate the effect of antithrombin supplementation in adult patients requiring venovenous extracorporeal membrane oxygenation for respiratory failure on heparin dose, adequacy of anticoagulation, and safety. DESIGN: Prospective randomized controlled trial...
September 17, 2020: Critical Care Medicine
Franziska Herpich, Fred Rincon
OBJECTIVES: Concise "synthetic" review of the state of the art of management of acute ischemic stroke. DATA SOURCES: Available literature on PubMed. STUDY SELECTION: We selected landmark studies, recent clinical trials, observational studies, and professional guidelines on the management of stroke including the last 10 years. DATA EXTRACTION: Eligible studies were identified and results leading to guideline recommendations were summarized...
September 17, 2020: Critical Care Medicine
Soo Jin Na, Ryoung-Eun Ko, Myeong Gyun Ko, Ahra Koh, Chi Ryang Chung, Gee Young Suh, Kyeongman Jeon
OBJECTIVES: The objective of this study was to investigate the risk factors for early medical emergency team reactivation (which is defined as repeated medical emergency team calls within 72 hr after the index medical emergency team call) in the patients remaining on the ward after index medical emergency team activation. DESIGN: Retrospective analysis with prospectively collected data. SETTING: A university-affiliated, tertiary referral hospital...
September 16, 2020: Critical Care Medicine
Maurizio Cereda, Clifford S Deutschman
No abstract text is available yet for this article.
September 15, 2020: Critical Care Medicine
Sarfaraz Rahiman, Remi Kowalski, Sit Yee Kwok, Sunit Matha, Bryn Jones, Joseph J Smolich, Jonathan P Mynard, Warwick Butt, Johnny Millar
OBJECTIVES: Milrinone is an inodilator widely used in the postoperative management of children undergoing cardiac surgery. The literature supporting its inotropic effect is sparse. We sought to study the effect of milrinone on the vasculature and its effects on the ventricular function using wave intensity analysis. We also intended to evaluate the feasibility of using wave intensity analysis by the bedside. DESIGN: prospective single-center observational study...
September 15, 2020: Critical Care Medicine
Chih-Yu Yang, Jia-Sin Liu, Wei-Cheng Tseng, Ming-Tsun Tsai, Ming-Huang Lin, Zih-Kai Kao, Yao-Ping Lin, Chih-Cheng Hsu, Der-Cherng Tarng
OBJECTIVES: Renal replacement therapy-requiring acute kidney injury frequently occurs in ICUs, which require evidence-based medical attention. However, in the postacute kidney injury patient population, the evidence regarding effective therapies to improve patient outcomes is lacking. Therefore, we aimed to examine whether the renin-angiotensin-aldosterone system blockade is effective in improving renal outcomes in postacute kidney injury patients who experienced temporary renal replacement therapy and have hypertension...
September 15, 2020: Critical Care Medicine
Stephanie Sibley, David M Maslove
No abstract text is available yet for this article.
September 15, 2020: Critical Care Medicine
Toshiaki Iba, Jerrold H Levy, Marcel Levi, Jean Marie Connors, Jecko Thachil
No abstract text is available yet for this article.
September 15, 2020: Critical Care Medicine
Allan J Walkey, R Christopher Sheldrick, Rahul Kashyap, Vishakha K Kumar, Karen Boman, Scott Bolesta, Fernando G Zampieri, Vikas Bansal, Michael O Harhay, Ognjen Gajic
OBJECTIVES: Use of observational data to inform the response and care of patients during a pandemic faces unique challenges. DESIGN: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study COVID 2019 Registry Core data and research methodology team convened over virtual meetings throughout March to June 2020 to determine best practice goals for development of a pandemic disease registry to support rapid data collection and analysis...
September 15, 2020: Critical Care Medicine
Cameron J Gibson, Dalia Alqunaibit, Kira E Smith, Matthew Bronstein, Soumitra R Eachempati, Anton G Kelly, Christina Lee, Jennifer A Minneman, Mayur Narayan, Jian Shou, Cassandra V Villegas, Robert J Winchell, Philip S Barie
OBJECTIVES: To describe the predictive utility of the D-dimer assay among patients with the coronavirus disease 2019 syndrome for unprovoked lower extremity deep venous thrombosis. DESIGN: Prospective observational study with retrospective data analysis. SETTING: Academic medical center surgical ICU. PATIENTS: Seventy-two intubated patients with critical illness from coronavirus disease 2019. INTERVENTIONS: Therapeutic anticoagulation after imaging diagnosis of the first three deep venous thrombosis cases was confirmed; therapeutic anticoagulation as prophylaxis thereafter to all subsequent ICU admissions...
September 15, 2020: Critical Care Medicine
Salvatore Grasso, Lucia Mirabella, Francesco Murgolo, Rossella Di Mussi, Luigi Pisani, Lidia Dalfino, Savino Spadaro, Michela Rauseo, Angela Lamanna, Gilda Cinnella
OBJECTIVES: Clinical observation suggests that early acute respiratory distress syndrome induced by the severe acute respiratory syndrome coronavirus 2 may be "atypical" due to a discrepancy between a relatively unaffected static respiratory system compliance and a significant hypoxemia. This would imply an "atypical" response to the positive end-expiratory pressure. DESIGN: Single-center, unblinded, crossover study. SETTING: ICU of Bari Policlinico Academic Hospital (Italy), dedicated to care patients with confirmed diagnosis of novel coronavirus disease 2019...
September 15, 2020: Critical Care Medicine
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"