Niklas Peter, Jutta Lichter, Lina Hagvall, Udo Bock, Brunhilde Blömeke
BACKGROUND: Fragrances are important contact allergens; however, investigation of their skin sensitization potency has been challenging in new approach methods (NAMs). Many fragrance chemicals are susceptible to autoxidation or can be metabolized by enzymes constitutively expressed in skin keratinocytes. Strong sensitizers can be formed in both of these processes. Further, keratinocytes can modulate the dendritic cell (DC) activation and maturation potential, a key event in the acquisition of contact allergy...
April 23, 2023: Contact Dermatitis
Amreeta Kaur, Rosemary Nixon
No abstract text is available yet for this article.
April 20, 2023: Contact Dermatitis
Andreas Brynolf, Inese Hauksson, Ola Bergendorff, Cecilia Svedman, Nils Hamnerius
BACKGROUND: During the COVID-19 pandemic, the use of face masks has increased among healthcare workers (HCWs). Questionnaire studies have shown a high frequency of self-reported facial adverse skin reactions. Case reports have been published on face mask-induced allergic contact dermatitis and urticaria. OBJECTIVES: To describe the results of the contact allergy investigations in consecutive HCWs investigated for skin reactions to face masks during the COVID-19 pandemic and the results of the chemical investigations of face masks supplied by the hospital...
April 18, 2023: Contact Dermatitis
Richard Brans, Silke Werner, Lara Obermeyer, Andreas Hansen, Christiane Altenburg, Albert Nienhaus
No abstract text is available yet for this article.
April 11, 2023: Contact Dermatitis
Andrea Bauer, Jacob P Thyssen, Timo Buhl, Thor Schütt Svane Nielsen, Lotte Seiding Larsen, Anne Birk Østerskov, Tove Agner
BACKGROUND: Measuring patient-reported outcomes is crucial to fully capture the burden of chronic hand eczema (CHE). OBJECTIVES: To assess the effect of delgocitinib cream on itch, pain and nine additional key signs and symptoms reported by patients with CHE using the Hand Eczema Symptom Diary (HESD). METHODS: In a double-blind, phase IIb dose-ranging trial (NCT03683719), 258 adults with mild to severe CHE were randomized to delgocitinib cream 1, 3, 8 or 20 mg/g or cream vehicle twice daily for 16 weeks...
April 10, 2023: Contact Dermatitis
Anne Herman, Liliane Marot, Marie Baeck
BACKGROUND: In 2008, numerous cases of allergic contact dermatitis caused by leather chairs (sofa dermatitis) were reported, with dimethylfumarate being the culprit allergen. However, octylisothiazolinone, methylisothiazolinone and cobalt have also been associated with cases of sofa dermatitis. An antifungal agent, 2-(thiocyanomethylthio)benzothiazole (TCMTB), has also previously been described as a contact allergen in leather. MATERIALS AND METHODS: Seven patients were referred to the Department of Dermatology of the Cliniques universitaires Saint-Luc, Brussels, Belgium with suspicion of allergic contact dermatitis caused by leather sofas...
April 10, 2023: Contact Dermatitis
Livia Francine Soriano, Shannon Kimberly Soriano, Deirdre A Buckley
No abstract text is available yet for this article.
April 4, 2023: Contact Dermatitis
Sadaf Sanii, Pierre Piletta
No abstract text is available yet for this article.
April 4, 2023: Contact Dermatitis
Theres Heichel, Richard Brans, Swen M John, Albert Nienhaus, Kathrin Nordheider, Annika Wilke, Flora K Sonsmann
BACKGROUND: Semipermeable membranes might be suitable for glove liners or comfort gloves in individuals with irritant contact dermatitis (ICD). OBJECTIVES: To evaluate the effects of different glove materials on inflammation and epidermal barrier impairment after experimental skin irritation. METHODS: Nine test areas on the volar forearms of 24 healthy volunteers were irritated with sodium lauryl sulfate (1%) and afterward covered for 6 days (6 or 8 h/day) with semipermeable Sympatex (SYM), vinyl (OCC), combinations of vinyl with Sympatex (SYM/OCC) or cotton (COT/OCC), or left uncovered (CON)...
April 4, 2023: Contact Dermatitis
Inaya Mahmoud, Desislava Kotirkova, Klimentina Gospodinova, Razvigor Darlenski, Jana Kazandjieva
No abstract text is available yet for this article.
April 3, 2023: Contact Dermatitis
Luca Boudet, Pascal Andujar, Marie-Thérèse Le Cam, Jean-Claude Pairon
No abstract text is available yet for this article.
April 2, 2023: Contact Dermatitis
Anders Boutrup Funch, Julie Friis Weber, Rebecca Kitt Davidson Lohmann, Veronika Mraz, Kelvin Yeung, Mia Hamilton Jee, Niels Ødum, Anders Woetmann, Jeanne Duus Johansen, Carsten Geisler, Charlotte Menné Bonefeld
BACKGROUND: CD8+ epidermal-resident memory T (TRM ) cells play central roles in local flare-up responses to experimental contact allergens by inducing massive influx of neutrophils to the epidermis upon allergen challenge. Whether similar immunopathogenic mechanisms are involved in the responses to clinically relevant contact allergens is unknown. METHODS: The immune response to cinnamal, ρ-phenylenediamine (PPD) and methylisothiazolinone (MI) was studied in a well-established mouse model for allergic contact dermatitis that includes formation of TRM cells by ELISA, flow cytometry, fluorescence microscopy analyses and cell depletion protocols...
March 31, 2023: Contact Dermatitis
Esen Özkaya, Zeynep Keskinkaya, Goncagül Babuna Kobaner
BACKGROUND: Allergic contact dermatitis (ACD) from topical ophthalmic medications (TOMs) poses an additional disease burden to patients who already suffer from eye problems. OBJECTIVES: To investigate the epidemiological/clinical profile of patients with periorbital ACD from TOMs in Turkey. PATIENTS AND METHODS: This was a retrospective, cross-sectional, single tertiary centre study based on files of 75 patch tested patients with suspected periorbital ACD from TOMs among a total of 2801 consecutively patch tested patients with suspected ACD of any origin between 1996 and 2019...
March 30, 2023: Contact Dermatitis
Alessandro Buonomo, Stefano Pucci, Tiziana Maria Angela De Pasquale
No abstract text is available yet for this article.
March 30, 2023: Contact Dermatitis
Marléne Isaksson, Ola Bergendorff, Nils Hamnerius, Ann Pontén, Cecilia Svedman, Inese Hauksson, Magnus Bruze
BACKGROUND: The two dialkylthiocarbamyl benzothiazole sulphides, dimethyl-thiocarbamylbenzothiazole sulphide (DMTBS) and diethylthio-carbamylbenzothiazole sulphide (DETBS) were shown to be good markers of both thiuram and mercaptobenzothiazole sensitivity. OBJECTIVES: To investigate if DMTBS and/or DETBS could be better markers of contact allergy to common rubber additives than the ones currently used. METHODS: Sixty-eight dermatitis patients were patch tested with DMTBS and DETBS, both at 1% in petrolatum (pet)...
March 28, 2023: Contact Dermatitis
J Xará, A Matos, J Soares, J Teixeira, L Ramos, M Gonçalo
No abstract text is available yet for this article.
March 27, 2023: Contact Dermatitis
Esen Özkaya
No abstract text is available yet for this article.
March 22, 2023: Contact Dermatitis
Annarita Antelmi, Jakob Dahlin, Katharine Hopkins, Cecilia Svedman, Magnus Bruze
No abstract text is available yet for this article.
March 21, 2023: Contact Dermatitis
Amanpreet Sidhu, Jan-Ø Holm, Tone K Bergersen, Jose H Alfonso
No abstract text is available yet for this article.
March 20, 2023: Contact Dermatitis
Liv Kroona, Camilla Ahlgren, Jakob Dahlin, Marléne Isaksson, Magnus Bruze
BACKGROUND: The mint flavour carvone (l-carvone) is considered a weak contact allergen. However, contact allergy to carvone is more prevalent in patients with oral lichen planus or oral lichenoid lesions (OLP/OLL). OBJECTIVE: Our aim was to investigate how carvone affects sensitized individuals through a use test with toothpaste containing carvone. Non-flavoured toothpaste served as control. METHODS: Subjects were patch tested prior to the use test-14 subjects allergic to carvone (11 with OLP/OLL), 20 subjects with OLP/OLL and 3 healthy controls...
March 16, 2023: Contact Dermatitis
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