Veronika Mraz, Anders B Funch, Mia H Jee, Anne-Sofie Ø Gadsbøll, Julie F Weber, Kelvin Yeung, Rebecca K D Lohmann, Alana Hawkes, Niels Ødum, Anders Woetmann, Dianne McKay, Deborah Witherden, Carsten Geisler, Charlotte M Bonefeld
BACKGROUND: Allergic contact dermatitis (ACD) is an inflammatory disease with a complex pathophysiology in which epidermal-resident memory CD8+ T (TRM ) cells play a key role. The mechanisms involved in the activation of CD8+ TRM cells during allergic flare-up responses are not understood. METHODS: The expression of CD100 and its ligand Plexin B2 on CD8+ TRM cells and keratinocytes before and after allergen exposure was determined by flow cytometry and RT-qPCR. The role of CD100 in the inflammatory response during the challenge phase of ACD was determined in a model of ACD in CD100 knockout and wild-type mice...
September 12, 2023: Contact Dermatitis