journal
https://read.qxmd.com/read/38739529/psma-avid-desmoid-tumor-of-the-abdominal-wall-on-18f-piflufolastat-pet-ct
#21
JOURNAL ARTICLE
Siddharth Bommekal, Lesley Flynt, Sanjit Om Tewari, Devaki Shilpa Sudha Surasi
Prostate-specific membrane antigen (PSMA) PET/CT is widely used in the evaluation of suspected metastasis for initial definitive therapy and suspected recurrence of prostate cancer. We outline a case report of a 62-year-old man with history of prostate cancer treated with surgery, salvage radiation, and hormonal therapy presenting with rising PSA levels. There was incidental detection of a PSMA-avid subcutaneous abdominal wall mass on PSMA PET/CT study, which was consistent with desmoid fibromatosis on an ultrasound-guided biopsy...
May 9, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38739496/dosimetric-considerations-for-177lu-dotatate-therapy-in-a-patient-with-chronic-renal-failure-under-hemodialysis
#22
JOURNAL ARTICLE
Sarah Chaib, Perrine Tylski, Choaib Lachachi, Tassadit Keniza, Elise Levigoureux
This case report explores the use of 177Lu-DOTATATE in a hemodialysis patient. For the first time, this study assesses the average dose received by the bone marrow, the primary organ at risk, using an original double estimation method through independently acquired imaging and biological samples counting data. Despite elevated doses, the absorbed doses to the bone marrow (0.662-0.740 Gy) were within safe limits. Radiation protection measurements for staff were also compliant. This work supports that effective early dialysis and systematic personalized dosimetry are crucial for hemodialysis patients undergoing 177Lu-PRRT due to their variability (residual excretion, treatment history, etc)...
May 9, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38739487/increased-psma-targeted-18f-dcfpyl-uptake-in-peripheral-t-cell-lymphoma
#23
JOURNAL ARTICLE
Charles J Milrod, Cory Brown, Anthony E Mega
Peripheral T-cell lymphomas are a heterogenous group of lymphomas with a high rate of extranodal disease. We present a case of increased 18F-DCFPyL uptake in peripheral T-cell lymphoma of subcutaneous tissue and bone. Familiarity with the increased 18F-DCFPyL uptake and extranodal presentation of peripheral T-cell lymphomas can avoid misinterpretation for metastatic disease.
May 9, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38739485/fdg-pet-ct-findings-of-primary-pulmonary-choriocarcinoma-in-a-postmenopausal-woman
#24
JOURNAL ARTICLE
Jun Zhang, Aisheng Dong, Yang Wang
Choriocarcinomas usually occur in the genital tracts of reproductive-age women after a gestational event. Primary pulmonary choriocarcinoma is very rare. We describe FDG PET/CT findings of primary pulmonary choriocarcinoma with multiple intrapulmonary metastases in a postmenopausal woman with elevated serum beta human chorionic gonadotropin level. On FDG PET/CT, the large primary lung tumor showed intense FDG uptake (SUVmax, 46), and the small intrapulmonary metastases showed variable FDG uptake (SUVmax, 27)...
May 9, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38722186/disappearance-of-elongated-pony-tail-sign-following-chemoradiotherapy-in-a-case-of-primary-cerebellopontine-angle-ependymoma-with-spinal-drop-metastasis-18f-fdg-pet-ct-scan-findings
#25
JOURNAL ARTICLE
Sarin Krishna, Abhiram G Ashwathanaryana, Rakesh Kumar Mishra, Shubham Asrani, Vinita Dewangan
Ependymomas are rare glial tumors that commonly arise from the lining cells of ventricular system and constitute ~10% of intracranial pediatric malignancies. The incidence of ependymoma in adults is rare. Due to close approximation with the ventricular system, subtentorial ependymomas are more prone to show cerebrospinal fluid metastasis compared with supratentorial ependymomas. We present a case of subtentorial cerebellopontine angle ependymoma with diffuse spinal drop metastases showing "elongated pony tail appearance" in a 69-year-old man with complete metabolic response on 18F-FDG PET/CT imaging following chemoradiotherapy...
May 9, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38717260/nondiagnostic-99mtc-mag3-diuresis-renography-studies-caused-by-propofol-sedation-a-case-series
#26
JOURNAL ARTICLE
Karan Bir Singh, Kurt Daley, Caryl Christian, Eva A Wegner, Monica A Rossleigh
99mTc-MAG3 diuresis renography is a noninvasive functional imaging technique used to assess clearance of radiotracer in a dilated urinary tract under high diuresis. It is commonly performed in patients to diagnose functionally significant urinary tract obstruction. In some pediatric patients, sedation is required to enable imaging. However, propofol, a commonly used IV sedative agent, is associated with altered renal hemodynamics. We report a case series of 3 pediatric patients at our institution who received propofol sedation to enable 99mTc-MAG3 diuresis renography using a F+0 protocol, outlining that some "abnormal" studies were in fact assessed to be nondiagnostic...
May 8, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38717245/false-negative-68ga-fapi-pet-ct-in-pediatric-thyroid-medullary-carcinoma-seen-with-68ga-dotatoc-pet-ct-and-18f-fdg-pet-ct
#27
JOURNAL ARTICLE
Mohamad B Haidar, Farah A Abou Zeid, Zarouhie Z Meguerian, Akram N Al-Ibraheem, Peter E Noun
In adults, 68Ga-FAP inhibitor (68Ga-FAPI) PET/CT outperforms 68Ga-radiolabeled somatostatin analog peptides (68Ga PET/CT) and 18F-FDG PET/CT in detecting thyroid lesions. This is the case of a 13-year-old boy newly diagnosed with medullary thyroid cancer with high calcitonin level. 68Ga PET/CT revealed the presence of only a primary thyroid lesion. Proven to be superior in detecting metastasis, 68Ga-FAPI PET/CT was performed. The results came out negative for primary and potential metastatic lesions. This case sheds shed light on false-negatives reported in 68Ga-FAPI PET/CT scans in pediatric patients, emphasizing the need for alternate radiotracers when a negative study is met...
May 8, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38693648/tumors-affect-the-metabolic-connectivity-of-the-human-brain-measured-by-18f-fdg-pet
#28
JOURNAL ARTICLE
Luca Pasquini, Mehrnaz Jenabi, Maya Graham, Kyung K Peck, Heiko Schöder, Andrei I Holodny, Simone Krebs
PURPOSE: 18F-FDG PET captures the relationship between glucose metabolism and synaptic activity, allowing for modeling brain function through metabolic connectivity. We investigated tumor-induced modifications of brain metabolic connectivity. PATIENTS AND METHODS: Forty-three patients with left hemispheric tumors and 18F-FDG PET/MRI were retrospectively recruited. We included 37 healthy controls (HCs) from the database CERMEP-IDB-MRXFDG. We analyzed the whole brain and right versus left hemispheres connectivity in patients and HC, frontal versus temporal tumors, active tumors versus radiation necrosis, and patients with high Karnofsky performance score (KPS = 100) versus low KPS (KPS < 70)...
May 2, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38693645/hepatic-psma-avid-postradiation-inflammation
#29
JOURNAL ARTICLE
Patrick Silveira, Aria Razmaria, Randy Yeh
A 62-year-old man with de novo large volume metastatic prostate cancer to the bone, liver, and nodes status post multiple lines of therapy including external beam radiation to T12-L2 approximately 13 months prior underwent 68Ga-PSMA PET/CT to determine eligibility for 177Lu-PSMA therapy. 68Ga-PSMA PET/CT demonstrated tracer-avid osseous and nodal lesions consistent with metastases. In addition, regional geographic tracer avidity was seen in the midline left hepatic lobe associated with capsular retraction and demonstrated no FDG avidity on subsequent imaging, probably inflammatory related to prior radiation to T12-L2...
May 2, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38693630/negative-18f-piflufolastat-pet-ct-but-positive-18f-fluciclovine-pet-ct-in-a-patient-with-biochemically-recurrent-prostate-cancer
#30
JOURNAL ARTICLE
Gary A Ulaner
An 83-year-old man with prostate cancer post external beam radiotherapy presented with biochemical recurrence (PSA, 29.7 ng/mL). PSMA-targeted 18F-Piflufolastat PET/CT was performed, but no avid lesions were identified. Given the high PSA and high suspicion for recurrence, an 18F-Fluciclovine PET/CT was performed. Fifteen 18F-fluciclovine-avid pelvic, abdominal, retrocrural, and left supraclavicular nodal metastases were then identified. Although the majority of prostate cancer metastases are avid on PSMA-targeted PET, some metastases are not...
May 2, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38689449/bilateral-adrenal-metastasis-of-prostatic-adenocarcinoma-on-68ga-psma-pet-ct-imaging
#31
JOURNAL ARTICLE
Ediz Beyhan, Ceyda Turan Bektaş, Mehmet Can Baloğlu, Zehranur Tosunoğlu, Tevfik Fikret Çermik
An 84-year-old man with prostate adenocarcinoma underwent 68Ga-PSMA PET/CT due to PSA recurrence. Foci of 68Ga-PSMA uptake were observed in bilateral adrenal glands. Adrenal MRI showed metastasis only in the left adrenal gland. Metastatic 68Ga-PSMA uptake was also observed in the mediastinum and bone. Enzalutamide treatment was started. Follow-up 68Ga-PSMA PET/CT scan showed regression in both adrenal gland metastases and other metastases.
May 1, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38689445/two-cases-of-synchronous-hodgkin-lymphoma-and-papillary-thyroid-carcinoma-in-18f-fdg-pet-ct
#32
JOURNAL ARTICLE
Ru Wang, Haidong Cai, Changcun Liu, Zhongwei Lv, Chao Ma
The concurrence of Hodgkin lymphoma and papillary thyroid carcinoma is a rare clinical event. Two women presented with a painless mass in the neck that was suspected malignancy by ultrasonography. Both cases shown in the 18F-FDG PET/CT images demonstrated multiple foci of increased FDG uptake in the neck, mimicking thyroid carcinoma with contralateral cervical lymph node metastases. Unexpectedly, the postoperative pathologies confirmed the thyroid lesion of papillary carcinoma and contralateral cervical lymph nodes of classical Hodgkin lymphoma...
May 1, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38689443/false-negative-neuroendocrine-tumor-identified-with-68ga-dotatoc-pet-ct-a-case-of-well-differentiated-somatostatinoma
#33
JOURNAL ARTICLE
Aurélie Moreau, Charlotte Chaouat, Thomas Walter, Aurélien Dupré, David Kryza
We report the case of a 25-year-old man who was undergoing follow-up for neurofibromatosis type 1. The man underwent 68Ga-DOTATOC PET/CT for a suspected well-differentiated duodenal neuroendocrine tumor. This examination did not reveal any significant uptake, whereas complementary 18F-FDG PET/CT showed moderate 18F-FDG uptake in the primary tumor as well as the adenopathy. Histology, a well-differentiated duodenal neuroendocrine tumor was confirmed, consistent with the diagnosis of somatostatinoma. Although rare, this well-differentiated neuroendocrine tumor should be kept in mind as a possible source of false-negative somatostatin receptor PET/CT findings...
May 1, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38689442/177lu-fap-2286-therapy-in-a-patient-with-metastatic-rhabdoid-meningioma
#34
JOURNAL ARTICLE
Zibei Wan, Wei Wang, Yue Chen, Wenlu Zheng, Zhanwen Huang
Rhabdoid meningioma is a rare subtype of meningioma and has a poor prognosis. Herein, we reported a patient of rhabdoid meningioma with multiple liver, pancreas, and bone metastases, who received 177Lu-FAP-2286 therapy. After 1 treatment cycle, 68Ga-FAP-2286 PET/CT revealed partial remission of the lesions.
May 1, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38689441/intramuscular-granular-cell-tumor-detected-on-68ga-psma-pet-ct
#35
JOURNAL ARTICLE
Muge N Engin, Adil Boz
Finding of the prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer (PC) cells that have made it possible to evaluate the patients with PC with a single imaging method. 68Ga-PSMA PET/CT is now part of the routine in patients with PC. After several years of clinical experience with PSMA tracers, the specificity is satisfactory; however, concerns about the specificity are raising day by day due to the newly laid out nonprostatic malignant and benign lesions with high PSMA expression...
May 1, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38689438/psma-and-fdg-pet-ct-findings-in-patient-with-dedifferentiated-liposarcoma-and-prostate-cancer-metastases
#36
JOURNAL ARTICLE
Xuhe Liao, Hongwei Sun, Xueqi Chen, Yan Fan, Jianhua Zhang
Dedifferentiated liposarcoma is an extremely rare and highly malignant tumor. We demonstrated a case of a 75-year-old man with significantly PSMA-avid and mildly FDG uptake-dedifferentiated liposarcoma in the retroperitoneal area. The double-tracer (PSMA and FDG) PET scans could further contribute to differential diagnosis and the following treatment strategy for patients who were suspected with prostate cancer metastases and other malignant tumors simultaneously.
May 1, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38689436/68ga-dotatoc-pictorial-essay-of-various-recurrent-meningiomas-rejected-for-treatment-with-177lu-dotatate-is-there-a-place-for-another-theranostic-examination
#37
JOURNAL ARTICLE
Aurélie Moreau, Aurélien Maureille, David Kryza
We report the cases of 4 patients treated for recurrent meningiomas of various grades. Pretreatment 68Ga-DOTATOC PET/CT was performed prior to screening for vectorized internal radiotherapy with 177Lu-DOTATATE or prior external radiotherapy to aid contouring. None of these patients had sufficient uptake to be eligible for 177Lu-DOTATATE or reliable contouring. Most recurrences were grades II and III, suggesting a loss of physiological somatostatin receptor overexpression in these tumors. Therefore, the benefit of treatment with 177Lu-DOTATATE in the current indication is questionable...
May 1, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38687008/free-tco4-in-99mtc-psma-scan-a-case-report-and-review-of-an-old-pitfall-in-the-new-era-of-modern-imaging
#38
JOURNAL ARTICLE
Pegah Sahafi, Kamran Aryana, Soroush Zarehparvar Moghadam, Kayvan Sadri, Emran Askari
In a recent 99mTc-HYNIC-PSMA study conducted at our department, we examined 2 patients with prostate cancer referred for initial staging on the same day. The whole-body scans revealed radiotracer uptake in the gastric mucosa and thyroid glands, alluding to high levels of free TcO4- in the injected vial. The scans were repeated after confirming acceptable radiopharmaceutical purity of 97% (normal range, 95%-100%). Interestingly, 1 patient had liver metastases at presentation, which remained non-PSMA-avid after repeating the scan...
April 30, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38687004/de-novo-metastatic-prostate-cancer-presenting-with-atypical-lower-limb-skeletal-metastases-detected-on-68ga-psma-pet-ct
#39
JOURNAL ARTICLE
Alexander Yip, June Yap
Metastatic prostate cancer to the appendicular skeleton is rare. We present an 86-year-old man with undiagnosed prostate cancer presenting with unilateral foot pain. CT and MRI demonstrated a sclerotic midfoot suggestive of an infiltrative process. In view of an elevated PSA, metastatic disease was suspected, and bone scan confirmed osteoblastically active pelvic and lower-limb skeletal lesions. Subsequent prostate biopsy confirmed prostate adenocarcinoma. Staging 68Ga-PSMA PET/CT demonstrated PSMA-avid intraprostatic malignancy with pelvic and right lower-limb skeletal metastases...
April 30, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38651792/ruptured-baker-cyst-on-18f-fdg-pet-ct
#40
JOURNAL ARTICLE
Emilie Mariëtte de Groot, Martinus Johannes van Amerongen, Marieke Janneke Martine Ploegmakers, Ingrid Henrica Antonia Zegers, Anne Isabelle Juliette Arens
A 78-year-old woman with diffuse large B-cell lymphoma was referred for an 18F-FDG PET/CT to evaluate therapy response after 6 cycles of R-mini-CHOP. A new 18F-FDG accumulation was noticed medial in the upper part of the right lower leg, spreading along the medial head of the gastrocnemius muscle. The shaft-bow-looking curvature, arch sign, of 18F-FDG revealed a fluid collection on CT. This typical pattern and its specific location are indicative of a ruptured Baker's cyst. It can manifest in 1 or both legs...
April 19, 2024: Clinical Nuclear Medicine
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