journal
https://read.qxmd.com/read/39025651/a-rare-atypical-intrapericardial-prostate-adenocarcinoma-metastasis-with-68ga-psma-11-pet-ct
#1
JOURNAL ARTICLE
Aurélie Moreau, Mayeul Tabutin, Amine Bouhamama, David Kryza
We report the case of an 88-year-old man recently diagnosed with prostate cancer. The patient underwent a 68Ga-prostate-specific membrane antigen-11 PET/CT for staging assessment. This examination revealed intense and expected uptake in the primary prostate cancer, widespread metastatic involvement including typical adenopathy and bone metastasis, and a less common pulmonary lymphangitic carcinomatosis. Most notably, we discovered a rare intrapericardial metastasis, which is an atypical site for metastasis in general and particularly for prostate adenocarcinoma...
July 18, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/39025634/recent-clinical-implications-of-fapi-imaging-and-therapy
#2
JOURNAL ARTICLE
Mahshid Kiani, Safura Jokar, Leila Hassanzadeh, Hossein Behnammanesh, Omid Bavi, Davood Beiki, Majid Assadi
The fibroblast activation protein (FAP) is a biomarker that is selectively overexpressed on cancer-associated fibroblasts (CAFs) in various types of tumoral tissues and some nonmalignant diseases, including fibrosis, arthritis, cardiovascular, and metabolic diseases. FAP plays a critical role in tumor microenvironment through facilitating proliferation, invasion, angiogenesis, immunosuppression, and drug resistance. Recent studies reveal that FAP might be regarded as a promising target for cancer diagnosis and treatment...
July 18, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/39010323/letter-to-the-editor
#3
JOURNAL ARTICLE
Ismet Sarikaya
No abstract text is available yet for this article.
July 16, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/39010320/clinical-factors-affecting-discrepancy-between-predicted-and-long-term-actual-lung-function-following-surgery
#4
JOURNAL ARTICLE
Jae-Woo Ju, Minseok Suh, Hongyoon Choi, Kwon Jooong Na, Samina Park, Gi Jeong Cheon, Young Tae Kim
PURPOSE: Lung cancer surgery outcomes depend heavily on preoperative pulmonary reserve, with forced expiratory volume in 1 second (FEV1) being a critical preoperative evaluation factor. Our study investigates the discrepancies between predicted and long-term actual postoperative lung function, focusing on clinical factors affecting these outcomes. METHODS: This retrospective observational study encompassed lung cancer patients who underwent preoperative lung perfusion SPECT/CT between 2015 and 2021...
July 16, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/39010319/elevated-68ga-fapi-activity-in-benign-carotid-body-tumors
#5
JOURNAL ARTICLE
Yang Xie, Wenxin Tang, Xi Chen, Xue Bai, Yue Chen
We present 68Ga-FAPI PET/CT findings of benign carotid body tumor in a 33-year-old woman. Benign carotid body tumor demonstrated intense tracer uptakes on 68Ga-FAPI PET/CT. Our case suggests that benign carotid body tumors should be considered in the differential diagnosis of neck mass with elevated 68Ga-FAPI activity.
July 16, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/39010313/a-peculiar-tau-accumulation-pattern-identified-via-18f-florzolotau-pet-imaging-in-a-patient-with-frontotemporal-dementia-caused-by-a-mutation-in-the-mapt-gene
#6
JOURNAL ARTICLE
Qijun Li, Hang Li, Zhaoxia Huang, Yanfeng Li, Ruixue Cui
We reported imaging findings with a peculiar tau accumulation pattern in a 56 year-old woman with frontotemporal dementia caused by Q351R mutation in the microtubule-associated protein tau (MAPT) gene. She had a 10-year history of gradually worsening memory loss. 18F-FDG PET demonstrated hypometabolism in medial temporal lobes, but 18F-florbetapir PET manifested no abnormal amyloid beta deposition, which ruled out Alzheimer disease. 18F-florzolotau PET showed tau proteins accumulated in medial temporal lobes, basal ganglia brainstem, and cerebellum...
July 16, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/39010310/burned-out-testicular-carcinoma-presenting-as-inferior-vena-cava-tumor-thrombus-with-pulmonary-tumor-embolism-on-fdg-pet-ct-a-case-report
#7
JOURNAL ARTICLE
Noa Shani Shrem, Daniel Levin, Keren Rouvinov, Gal Ben-Arie, Ilya Liberzon, Nir Hod
"Burned-out" testicular tumor is a very rare clinical phenomenon, which refers to the presence of a metastatic germ cell tumor with no clinical findings in the testicle due to spontaneous regression of the primary testicular lesion. We present an unusual case of burned-out testicular embryonal germ cell carcinoma presenting as an extensive inferior vena cava tumor thrombus with malignant pulmonary embolism in which FDG PET/CT played a pivotal role in detecting the extent and significance of the disease.
July 16, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38991199/comparison-of-68ga-fapi-04-and-18f-fdg-pet-ct-in-fumarate-hydratase-deficient-renal-cell-carcinoma-a-prospective-and-single-center-study
#8
JOURNAL ARTICLE
Shuhui Huang, Haoyang Liu, Hongyuan Dai, Mengfang Qi, Minggang Su, Hao Zeng, Rui Huang
PURPOSE: Fumarate hydratase-deficient renal cell cancer (FHRCC) is a rare and aggressive form of renal cell carcinoma. The diagnostic value of 68Ga-FAPI PET/CT for FHRCC remains unexplored. Therefore, we compared the potential value of 68Ga-FAPI-04 and 18F-FDG PET/CT in FHRCC. PATIENTS AND METHODS: Patients with FHRCC underwent 68Ga-FAPI-04 and 18F-FDG PET/CT from May 2022 to December 2023. The SUVmax and tumor-to-liver ratio (TLR) of both tracers were compared using the Wilcoxon signed rank test...
July 10, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38973086/subacute-cerebral-infarct-an-unusual-cause-of-radiotracer-uptake-at-18f-psma-pet-ct
#9
JOURNAL ARTICLE
Vaibhav Jain, Lacey McIntosh
Prostate-specific membrane antigen (PSMA) PET/CT has become an unparalleled modality in the diagnosis of primary and recurrent prostatic adenocarcinoma, often revealing sites of disease that were previously invisible on conventional imaging. In this 78-year-old man with suspected prostate cancer recurrence, PSMA PET/CT revealed focal radiotracer uptake in the brain, which would ordinarily raise suspicion for metastases, but was a false positive in the setting of a recent stroke. Increased PSMA uptake has been reported in subacute infarcts and primary and secondary brain tumors...
July 8, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38973081/comparing-the-diagnostic-value-of-fdg-pet-or-pet-ct-with-fdg-pet-mr-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Chun-Yi Lin, Ming-Che Chang, Chia-Hung Kao
BACKGROUND: The aim of this study was to compare the diagnostic value of 18F-FDG PET or PET/CT with FDG PET/MR in patients with inflammatory bowel disease (IBD). METHODS: A comprehensive search was performed in PubMed for studies reporting the diagnostic performance of FDG PET (PET/CT) and FDG PET/MR in IBD from the inception of the database to March 14, 2024, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Fourteen studies were included in this systematic review and meta-analysis...
July 8, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38968595/177lu-dotatate-uptake-in-the-lungs-of-a-patient-with-covid-19-pneumonia
#11
JOURNAL ARTICLE
Tomoki Matsushita, Yoichi Otomi, Naoko Okada, Takashi Kawanaka, Hideki Otsuka
A 76-year-old woman with liver and bone metastasis of a duodenal neuroendocrine tumor received peptide receptor radionuclide therapy with 177Lu-DOTATATE. Scintigraphy with SPECT/CT performed 4 days after the treatment demonstrated 177Lu-DOTATATE uptake as multifocal ground glass opacities in the bilateral lungs. This uptake was considered to be due to COVID-19 pneumonia because the patient was infected with the virus 7 days prior to the treatment. The lung opacities became smaller, showing a decreased uptake, 2 months later, after the second treatment...
July 4, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38968578/68ga-fapi-pet-ct-visualized-benign-metastasizing-leiomyoma-with-bone-invasion
#12
JOURNAL ARTICLE
Tianxing Fang, Chongjiao Li, Yueli Tian, Zhiwei Xiao, Yong He
Benign metastasizing leiomyoma (BML) is a rare disease associated with pelvic leiomyoma. We report 18F-FDG and 68Ga-FAPI PET/CT findings in a 51-year-old woman with multiple BMLs. The mass in the abdominopelvic cavity and other metastatic lesions showed highly increased 68Ga-FAPI uptake, whereas uptake of 18F-FDG in those lesions was low. Our report demonstrates that 68Ga-FAPI PET/CT showed a different result in detecting BML to 18F-FDG PET/CT, and 68Ga-FAPI PET/CT may be a promising method for whole-body evaluate metastases...
July 4, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38968555/18f-fdg-pet-ct-of-benign-tracheal-schwannoma
#13
JOURNAL ARTICLE
Kai-Yu Lu, You Cheng, Zhen-Peng Jiang, Dan Shao, Si-Yun Wang
Schwannoma is a benign tumor originating from Schwann cells. It commonly occurs in the head, neck, and extremities, but rarely occurs in the trachea. Tracheal schwannoma is usually asymptomatic. We reported the 18F-FDG PET/CT findings of a 61-year-old man with bronchoscopically biopsy-proven schwannoma, which presented challenges in differentiation from certain benign tumors and low-grade malignancies in the trachea.
July 4, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38968541/feasibility-of-using-a-novel-drop-in-gamma-probe-for-99mtc-psma-i-s-guided-lymph-node-detection-during-robot-assisted-radical-prostatectomy-for-primary-prostate-cancer
#14
JOURNAL ARTICLE
Nina N Harke, Christian Fuhrmann, Christoph Czerner, Frank Rudolf, Tobias Ludwig Ross, Olga Katzendorn, Frank Bengel, Markus A Kuczyk, Desiree Weiberg, Thorsten Derlin
PURPOSE: Prostate-specific membrane antigen (PSMA)-targeted radioguided surgery (RGS) has gained increased interest in prostate cancer (PCa). This analysis aims to evaluate the feasibility, safety, and limitations of RGS with a novel drop-in gamma probe in primary PCa. PATIENTS AND METHODS: The data of 13 patients with primary PCa undergoing RGS were analyzed retrospectively. After preoperative administration of 99mTc-PSMA-I&S, a SPECT/CT was conducted and a robotic radical prostatectomy was performed the following day including intraoperative assessment of the lymph node stations using a novel robotic drop-in gamma probe...
July 4, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38968597/increased-uptake-of-18f-thk5351-in-isocitrate-dehydrogenase-wildtype-glioblastoma-but-not-in-meningioma
#15
JOURNAL ARTICLE
Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto, Keisuke Miyake, Yoshihiro Nishiyama
18F-THK5351 demonstrates a strong binding affinity and selectivity for tau. However, off-target binding with monoamine oxidase-B enzyme, highly expressed in the outer mitochondrial membranes of astrocytes, is possible. In a case with isocitrate dehydrogenase-wildtype glioblastoma, 11C-MET PET and 18F-THK5351 PET exhibited increased uptake in the tumor. Conversely, in another case with intracranial meningioma, MET PET revealed increased uptake in the tumor, whereas 18F-THK5351 PET showed no abnormal uptake in the tumor...
July 3, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38968592/a-rare-case-of-follicular-dendritic-cell-tumor-of-the-abdominal-cavity-visualized-by-18f-alf-nota-octreotide-pet-ct
#16
JOURNAL ARTICLE
Guozhu Hou, Xin Cheng, Li Sun, Xuejuan Wang, Rong Zheng
Positivity of follicular dendritic cell tumor in somatostatin receptor imaging is rare. A 68-year-old woman underwent ultrasound in health examination. The results showed abnormal echoes in the pancreatic head region, suggestive of a neuroendocrine tumor of the pancreatic head. 18F-AlF-NOTA-octreotide PET/CT was performed for staging. 18F-AlF-NOTA-octreotide PET/CT revealed an irregular mass between the caudate lobe of the liver and the pancreatic head with heterogeneously increased uptake, which was later confirmed as follicular dendritic cell tumor by pathological examination...
July 3, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38968590/imaging-of-hypoxia-in-liver-tumors-with-18f-fmiso-pet-before-selective-internal-radiotherapy-with-90y-microspheres
#17
JOURNAL ARTICLE
Cigdem Soydal, Burak Demir, Ecenur Dursun, Gizem Sutcu, Emre Can Celebioglu, Mehmet Sadik Bilgic, Nuriye Ozlem Kucuk
Hypoxia is a known cause of resistance to radiotherapy and chemotherapy. Although there are multiple studies in external radiation therapies based on hypoxia PET, the effect of hypoxia in radioembolization is largely unknown. Here we present 2 cases of hepatocellular carcinoma patients from a prospective study with different lesion characteristics on pretreatment 18F-FMISO PET and varying responses on 18F-FDG PET.
July 3, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38968579/atypical-bone-involvement-in-erdheim-chester-disease-showing-no-or-subtle-structure-changes-and-increased-activity-on-fdg-pet-ct
#18
JOURNAL ARTICLE
Zhengguang Xiao, Shun Dai, Aisheng Dong, Yushu Bai
Bones are the most common sites involved in Erdheim-Chester disease. On imaging, the bone involvement in Erdheim-Chester disease typically presents as osteosclerotic lesions, and osteolytic lesions are unusual. Bone lesions showing no or subtle structure changes are rarely reported. We describe FDG PET/CT findings in a case of Erdheim-Chester disease with atypical bone involvement. The bone lesions showed no or subtle structure changes without obvious osteosclerosis or osteolysis on radiographs and CT, and increased FDG activity mimicking lymphoma...
July 3, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38968571/fdg-pet-ct-in-staging-and-response-evaluation-of-primary-urothelial-carcinoma-of-the-urethra
#19
JOURNAL ARTICLE
Jun Zhang, Aisheng Dong, Yang Wang
Primary urethral urothelial carcinoma is a rare aggressive tumor with a high propensity for local invasion and regional and distal metastases. We describe the usefulness of FDG PET/CT in management of a patient with primary urethral urothelial carcinoma. FDG PET/CT at initial staging showed FDG-avid primary tumor and lymph node metastasis of the left groin, and mild or no activity of the lung metastases due to small size. FDG PET/CT after 4 cycles of chemotherapy showed progression of the primary tumor and lung metastases, partial response of the left inguinal lymphadenopathy, and multiple new sites of FDG-avid metastases...
July 3, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38968570/thoracic-smarca4-deficient-undifferentiated-tumor-mimicking-malignant-pleural-mesothelioma-on-fdg-pet-ct
#20
JOURNAL ARTICLE
Haibo Wu, Yinting Zhou, Aisheng Dong, Yang Wang, Yan Han
We describe contrast-enhanced CT and FDG PET/CT findings in a case of thoracic SMARCA4-deficient undifferentiated tumor with extensive pleural involvement and mediastinal lymph node metastases. Contrast-enhanced CT showed multiple enhancing right-sided pleural masses and soft tissue plaques and enlarged mediastinal lymph nodes. The pleural lesions and mediastinal lymph nodes showed intense FDG uptake mimicking malignant pleural mesothelioma with mediastinal lymph node metastases.
July 3, 2024: Clinical Nuclear Medicine
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