Journals Clinical Neurology and Neurosu...

Clinical Neurology and Neurosurgery
Shaohua Tan, Yuanting Liu, Futao Li, Meng Han, Mingxin Ye
OBJECTIVES: 1.To explore the incidence of concurrent gouty arthritis (GA) during hospitalization in patients with different subtypes of acute stroke. 2.To investigate disparities in acute cerebral infarction patients with coexisting GA undergoing various antiplatelet strategies. MATERIALS AND METHODS: Data from acute stroke patients admitted to the Affiliated Panyu Central Hospital of Guangzhou Medical University, from January 2019 to December 2021, underwent screening...
May 13, 2024: Clinical Neurology and Neurosurgery
Vinay Suresh, Mainak Bardhan, Shankhaneel Ghosh, Yash Chandani, Prakasini Satapathy, Priyanka Roy, Muhammad Aaqib Shamim, Aravind P Gandhi, Mokanpally Sandeep, Sarvesh Rustagi, Ranjit Sah, Bijaya K Padhi
BACKGROUND: Parkinson's disease (PD) is a progressive neurological condition that affects movement and coordination. Orexin-A (OXA) is an excitatory neuropeptide that is found throughout the central nervous system. There is growing interest in investigating the potential diagnostic and therapeutic utility of OXA in PD. To date, studies have reported a wide range of OXA concentrations in patients with PD. In this review, we discuss the current understanding of the dysregulation of OXA in PD and analyze its levels in the CSF...
May 12, 2024: Clinical Neurology and Neurosurgery
Minaam Farooq, Dahir Ashfaq, Kaleem Ullah Ranjha, Anil Ergen, Oday Atallah, Amr Badary, Gianluca Scalia
BACKGROUND: The Liliequist membrane (LM) represents a crucial yet challenging anatomical structure in neuroanatomy. First observed in 1875 and later elucidated by Bengt Liliequist in 1956, the LM's precise anatomical description and boundaries remain complex. Its significance extends to neurosurgery, impacting various procedures like endoscopic third ventriculocisternostomies, aneurysm and tumor surgeries, treatment of suprasellar arachnoid cysts, and managing perimesencephalic hemorrhages...
May 11, 2024: Clinical Neurology and Neurosurgery
Hiroshi Kataoka, Kaoru Kinugawa, Mayu Sugata, Shusaku Morita, Toshiteru Miyasaka, Kazuma Sugie
OBJECTIVES: Psychosis, especially in delusions, greatly impairs the quality of life of patients with Parkinson's disease (PD) and their caregivers. Few objective risk indicators of the association between psychosis and clinical features has been reported. It is unclear whether the reduction in DAT binding represents the underlying mechanism of delusion or its association. There are no long-term data on the objective prognostic value of DAT binding for delusions. We investigated whether DAT binding at baseline can be a prognostic risk factor for future development of PD delusions...
May 10, 2024: Clinical Neurology and Neurosurgery
Yılmaz Karaduman, Azize Serçe, Arzu Muz, Servi Yıldırım, Ismail Eren Durmuş, Suna Akın Takmaz
OBJECTIVES: The study aims to retrospectively compare steroid and radiofrequency treatments for the greater occipital nerve(GON) under ultrasound guidance in chronic migraine. METHODS: Monthly average headache attack frequency, attack duration, visual analog scale(VAS) and the number of days analgesics were taken were recorded. Under ultrasound guidance, GON block was administered once a week for a total of four sessions. In the final session, 4 mg of dexamethasone was added to the local anesthetic for the steroid group (n:26)...
May 9, 2024: Clinical Neurology and Neurosurgery
Erica D McKenzie, Surbhi Chaturvedi, Steven R Peters
BACKGROUND AND PURPOSE: Basilar artery stenting is a rescue therapy in the management of hyperacute stroke. Published data on efficacy and safety are limited. METHODS: A systematic review of published studies was performed in accordance with PRISMA guidelines. Inclusion criteria were adult patients with ischemic stroke with permanent basilar artery stent placement within 48 h of onset. Data were extracted by two independent reviewers. Additional cases from our institution were identified via a local stroke registry...
May 9, 2024: Clinical Neurology and Neurosurgery
Cenk Murat Ünverdi, Cemile Haki, Kaya Saraç, Suat Kamışlı
OBJECTIVE: We aimed to compare the radiological and clinical characteristics of COVID-19-positive and -negative acute ischemic stroke (AIS) patients who underwent revascularization and to evaluate whether COVID-19 has an effect on revascularization and outcome in AIS patients with COVID-19 infection. METHODS: Consecutive COVID-19 positive and negative AIS patients who underwent intravenous thrombolysis and/or endovascular therapy in our hospital between March 2020 and February 2022 were included in this study...
May 9, 2024: Clinical Neurology and Neurosurgery
Dayuan Zhong, Hui Cheng, Zhuoyan Xian, Yanhai Ren, Huanjie Li, Xueming Ou, Pingwen Liu
Chronic Subdural Hematoma (CSDH) is a common hemorrhagic disease in neurosurgery, and with the intensification of global aging, its incidence is gradually increasing. With the advancement of scientific technology, the etiological concepts and surgical treatments for CSDH have continually evolved over time. Currently, neuroscientists' understanding of CSDH is no longer confined to bridging vein rupture; exploration of various mechanisms such as angiogenesis, maturation of blood vessels, and inflammation is also underway...
May 9, 2024: Clinical Neurology and Neurosurgery
Danyca Shadé Breedt, Brad Harrington, Ian Scott Walker, Armin Gretchel, Adriaan Johannes Vlok
BACKGROUND: Gold standard for determining intracranial pressure (ICP), intraventricular catheter, is invasive with associated risks. Non-invasive investigations like magnetic resonance imaging and ultrasonography have demonstrated correlation between optic nerve sheath diameter (ONSD) and raised ICP. However, computed tomography (CT) is accessible and less operator-dependent. Literature shows variable results regarding correlations between ICP and ONSD on CT. The study aimed to investigate correlations between raised ICP and ONSD, eyeball transverse diameter (ETD), and ONSD/ETD ratios on CT scan(s) of severe head injuries...
May 8, 2024: Clinical Neurology and Neurosurgery
Ritwick Mondal, Shramana Deb, Gourav Shome, Anjan Chowdhury, Kuntal Ghosh, Julián Benito-León, Durjoy Lahiri
INTRODUCTION: Seizure disorders have often been found to be associated with corpus callosum injuries, but in most cases, they remain undiagnosed. Understanding the clinical, electrographic, and neuroradiological alternations can be crucial in delineating this entity. OBJECTIVE: This systematic review aims to analyze the effects of corpus callosum injuries on seizure semiology, providing insights into the neuroscientific and clinical implications of such injuries...
May 7, 2024: Clinical Neurology and Neurosurgery
Syed A Sarwar, Geoffrey R O'Malley, Julia Botvinov, Yasmin Khan, Rohit Prem Kumar, Mir Ali, Nicholas D Cassimatis, Jasdeep S Hundal, Nitesh V Patel
OBJECTIVE: The relationship between environmental contaminants and brain tumor incidence in adults has been thoroughly explored but research into how these contaminants affect pediatric brain tumor (PBT) incidence has not been explored. Children, typically having more limited geographical movement and thus more consistent environmental contaminant exposure, might offer more reliable insights into which environmental contaminants affect the incidence of brain tumors. The present study is the first to focus on exploring whether a possible association exists between the incidence of PBTs and exposure to environmental pollutants in New Jersey (NJ)...
May 7, 2024: Clinical Neurology and Neurosurgery
Yilong Zheng, Li Wei, Samantha Ya Lyn Ang, Hwee Lan Ng, Wing Lok Au, Kay Yaw Tay, Zheyu Xu, Wai Hoe Ng, Louis Chew Seng Tan, Shermyn Xiumin Neo, Kai Rui Wan
INTRODUCTION: The decision to offer deep brain stimulation (DBS) to elderly patients with Parkinson's disease (PD) presents challenges due to higher perceived risks and uncertain long-term benefits. Here, we aimed to compare the outcomes after DBS for elderly versus non-elderly patients with PD. METHODS: We analyzed data from our institutional cohort and retrieved publicly available data through a systematic review. The exposure was age at DBS electrode insertion, which was defined as elderly (≥70 years old) and non-elderly (<70 years old)...
May 7, 2024: Clinical Neurology and Neurosurgery
Karen S Chen, Ayaz Khawaja, Edward Xu, Rania A Mekary, Henri Vaitkevicius, Ali Aziz-Sultan, Rose Du, Nirav J Patel
The November 2013 online publication of ARUBA, the first multi-institutional randomized controlled trial for unruptured brain arteriovenous malformations (AVMs), has sparked over 100 publications in protracted debates METHODS: This study sought to examine inpatient management patterns of brain AVMs from 2009 to 2016 and observe if changes in U.S. inpatient management were attributable to the ARUBA publication using interrupted time series of brain AVM studies from the National Inpatient Sample data 2009-2016...
May 6, 2024: Clinical Neurology and Neurosurgery
Silvio Porto Junior, Davi Amorim Meira, Beatriz Lopes Bernardo da Cunha, Jefferson Fontes, Hugo Nunes Pustilnik, Matheus Gomes da Silva da Paz, Taiane Brito Araujo, Tancredo Alcântara, Jules Carlos Dourado, Leonardo Miranda de Avellar
BACKGROUND: Craniosynostosis, a developmental craniofacial anomaly, can impair brain development and cause abnormal skull shape due to premature closure of one or more cranial sutures. Traditional surgical treatments have evolved from open operations to minimally invasive endoscopic techniques. This systematic review and meta-analysis aim to evaluate the effectiveness and safety of the endoscopic approach in craniosynostosis correction. METHODS: Adhering to Cochrane Group standards and the PRISMA framework, this review utilized databases like PubMed, Embase, and Web of Science, focusing on clinical and surgical outcomes of endoscopic craniosynostosis operations up to December 2023...
May 3, 2024: Clinical Neurology and Neurosurgery
Yue-Qi Du, Guo-Qing Cui, Mao-Yang Qi, Bo-Yan Zhang, Jian Guan, Feng-Zeng Jian, Wan-Ru Duan, Zan Chen
OBJECTIVE: To develop and validate a computed tomography (CT)-based scoring system for evaluating the risk of dural defects (DDs) in anterior surgery for cervical ossification of the posterior longitudinal ligament (OPLL). METHODS: We retrospectively analyzed CT imaging features of 114 OPLL patients in our institute who received anterior decompression surgery. Intraoperative DDs were found in 16 patients. A multivariable logistic regression was used to evaluate the predictors...
May 1, 2024: Clinical Neurology and Neurosurgery
Zhenhang Zhai, Ke Sun, Tinghong Liu, Shuli Liang, Changhong Ding, Shuhong Ren, Shanpo Wei, Feng Zhai, Guojun Zhang
BACKGROUND: Pantothenate kinase-associated neurodegeneration (PKAN) is a type of inherited metabolic disorder caused by mutation in the PANK2 gene. The metabolic disorder mainly affects the basal ganglia region and eventually manifests as dystonia. For patients of dystonia, their dystonic symptom may progress to life-threatening emergency--status dystonicus. OBJECTIVE: We described a case of a child with PKAN who had developed status dystonicus and was successfully treated with deep brain stimulation (DBS)...
May 1, 2024: Clinical Neurology and Neurosurgery
Youpei Wang, Tiru Shan, Peipei Mao, Yi Jiang, Zhao Wang
AIM: Immunoinflammatory response plays an important role in the pathophysiological process of ischemic stroke (IS). Forkhead box P3 (FOXP3) is a master regulator for immune cells. Polymorphisms of FOXP3 gene might contribute to the susceptibility of IS. This study aimed to explore the association between FOXP3 gene polymorphisms (rs3761548 and rs2232365) and IS susceptibility in the Chinese Han population. METHODS: Polymerase chain reaction and Sanger sequencing were used to detect the genotype of FOXP3 gene rs3761548 and rs2232365 polymorphisms...
April 30, 2024: Clinical Neurology and Neurosurgery
Faraz Behzadi, Diego D Luy, Peter A Schaible, Joseph F Zywiciel, Ava M Puccio, Anand V Germanwala
INTRODUCTION: Severe traumatic brain injury (TBI) presentation and late clinical outcomes are usually evaluated by the Glasgow Outcome Scale-Extended (GOS-E), which lacks strong prognostic predictability. Several blood biomarkers have been linked to TBI, such as Tau, GFAP, UCH-L1, S-100B, and NSE. Clinical values of TBI biomarkers have yet to be evaluated in a focused multi-study meta-analysis. We reviewed relevant articles evaluating potential relationships between TBI biomarkers and both early and 6-month outcomes...
April 30, 2024: Clinical Neurology and Neurosurgery
Timothy Daly, Markku Kurkinen
No abstract text is available yet for this article.
April 30, 2024: Clinical Neurology and Neurosurgery
Agata Kowalska, Monika Figura, Mateusz Zawadka, Dariusz Koziorowski
Pyruvate dehydrogenase complex (PDC) deficiency is a genetic mitochondrial disease mostly associated with severe lactic acidosis, rapid progression of neurological symptoms and death during childhood. We present a 33-year-old male with PDC deficiency caused by a Val262Leu mutation in PDHA1gene. He demonstrated generalized dystonia affecting trunk and upper extremities and paraparesis as the most significant features, with onset of symptoms at age 8. Brain MRI showed bilaterally increased signal within the globus pallidus, typical of Leigh syndrome...
April 30, 2024: Clinical Neurology and Neurosurgery
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