journal
MENU ▼
Read by QxMD icon Read
search

Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

journal
https://read.qxmd.com/read/30779241/asthma-with-multiple-allergic-comorbidities-is-associated-with-complete-response-to-omalizumab
#1
LETTER
Lucile Sesé, Marion Schneider, Melisande Bourgoin, Philippe Saint-Pierre, Nathalie Lambert, Tamazoust Guiddir, Rémi Couderc, Flore Amat, Jocelyne Just
Patients with severe asthma constitute a heterogeneous population, and different phenotypes have been identified both in adults and children. Severe asthma affects 4.5% of children with current asthma. Several studies have shown that omalizumab, a humanized anti-IgE monoclonal antibody, is effective in exacerbations and asthma control, and well tolerated in children with severe allergic asthma. However, as biotherapy response varies among patients, it is important to clearly define which children will benefit the most from treatment...
February 18, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30776162/nasal-ige-production-in-allergic-rhinitis-impact-of-rhinovirus-infection
#2
Ahmed Hamed, DeVon C Preston, Will Eschenbacher, Dilawar Khokhar, Lisa Workman, John W Steinke, Peter Heymann, Monica Lawrence, Manuel Soto-Quiros, Thomas A E Platts-Mills, Spencer Payne, Larry Borish
BACKGROUND: Rhinovirus (RV) infections exacerbate asthma in part by enhancing an allergic state and these exacerbations can be mitigated via administration of anti-IgE. OBJECTIVE: We investigated the presence of local IgE production in the nose of allergic and non-allergic subjects and assessed whether this was enhanced by RV. METHODS: Local production of specific IgE was determined by comparing ratios of specific to total IgE concentrations between nasal and serum samples...
February 18, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30771249/academic-achievement-of-adolescents-with-asthma-or-atopic-disease
#3
Bronwyn K Brew, Joakim Söderberg, Cecilia Lundholm, Soren Afshar, Kirsten Holmberg, Catarina Almqvist
BACKGROUND: Over a fifth of children and adolescents suffer with asthma or atopic disease. It is unclear whether asthma impacts academic performance in children and adolescents, and little is known about the association of eczema, food allergy or hay fever and academic performance. OBJECTIVE: To examine whether asthma, eczema, food allergy or hay fever impacts on adolescent academic performance and to assess the role of unmeasured confounding. METHODS: This study used the Childhood and Adolescent Twin Study of Sweden cohort born 1992-1998...
February 16, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30742718/parental-asthma-and-risk-of-autism-spectrum-disorder-in-offspring-a-population-and-family-based-case-control-study
#4
Tong Gong, Cecilia Lundholm, Gustaf Rejnö, Sven Bölte, Henrik Larsson, Brian M D'Onofrio, Paul Lichtenstein, Catarina Almqvist
BACKGROUND: Associations between parental asthma and prenatal exposure to asthma medications with offspring autism spectrum disorder (ASD) have been reported. However, the associations might be confounded by unmeasured (genetic and shared environmental) familial factors. OBJECTIVE: We investigated the association between (a) maternal/paternal asthma and offspring ASD, and (b) prenatal exposures to β2-agonists, other asthma medications and offspring ASD using cases and controls selected from the population as well as biological relatives with different degrees of relatedness...
February 11, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30737857/endothelin-1-mediates-aspergillus-fumigatus-induced-airway-inflammation-and-remodelling
#5
Briony Labram, Sara Namvar, Tracy Hussell, Sarah E Herrick
BACKGROUND: Asthma is a chronic inflammatory condition of the airways and patients sensitised to airborne fungi such as Aspergillus fumigatus have more severe asthma. Thickening of the bronchial subepithelial layer is a contributing factor to asthma severity for which no current treatment exists. Airway epithelium acts as an initial defence barrier to inhaled spores, orchestrating an inflammatory response and contributing to subepithelial fibrosis. OBJECTIVE: We aimed to analyse the production of profibrogenic factors by airway epithelium in response to A...
February 8, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30737842/home-based-cow-s-milk-reintroduction-using-a-milk-ladder-in-children-less-than-3-years-old-with-ige-mediated-cow-s-milk-allergy
#6
Heidi Britt Ball, David Luyt
BACKGROUND: The development of tolerance to cow's milk in allergic children is best determined by supervised baked milk exposure. Widely recommended hospital-based challenges can potentially delay contact because of resources limitations. OBJECTIVE: We sought to determine the efficacy and safety of our low-dose home-based reintroduction programme. METHODS: In our allergy service, children with IgE-mediated cow's milk allergy who met a set criteria (presenting with skin and/or gastrointestinal symptoms only and skin prick test <8mm) are considered for home-based milk reintroduction (HMR)...
February 8, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30734376/clinical-and-immunological-differences-between-asymptomatic-hdm-sensitized-and-hdm-allergic-rhinitis-patients
#7
Mihaela Zidarn, Maša Robič, Anja Krivec, Mira Šilar, Yvonne Resch-Marat, Susanne Vrtala, Peter Kopač, Nissera Bajrović, Rudolf Valenta, Peter Korošec
BACKGROUND: Confirmation of the clinical relevance of sensitisation is important for the diagnosis of allergic rhinitis. OBJECTIVE: To investigate the usefulness of an in vitro basophil activation test and component-resolved diagnosis in distinguishing between symptomatic allergic rhinitis patients and asymptomatic sensitization to house dust mites (HDMs). METHODS: Thirty-six subjects with a positive skin prick test (SPT) for HDM were divided into a symptomatic (n=17) and an asymptomatic (n=19) group on the basis of their clinical history and a nasal provocation test...
February 7, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30723963/airway-smooth-muscle-reduction-after-bronchial-thermoplasty-in-severe-asthma-correlates-with-fev-1
#8
LETTER
Julia N S d'Hooghe, Annika W M Goorsenberg, Nick H T Ten Hacken, Els J M Weersink, Joris J T H Roelofs, Thais Mauad, Pallav L Shah, Jouke T Annema, Peter I Bonta
Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma patients in whom the airways are treated with radio-frequency energy with the aim to improve asthma symptoms by reducing airway smooth muscle (ASM).1 So far, three patient cohorts reported ASM mass reduction after BT by using α-smooth muscle actin staining (α-SMA).2-4 However, the exact mechanism of action of BT and its related responder profile is unclear. This article is protected by copyright. All rights reserved.
February 5, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30723958/ptx3-and-d-dimer-in-children-with-asthma-a-real-world-study
#9
LETTER
Amelia Licari, Gianluigi Marseglia, Mara De Amici, Giorgio Ciprandi
Pathophysiological characteristics of asthma are: bronchial hyperresponsiveness, airway infiltration by inflammatory cells, and remodelling. Asthma treatment is targeted to achieve the best control of symptoms and risk factors. Anti-inflammatory agents are the most common medications used, since inflammation is the grounds of asthma. In children, the most common phenotype/endotype is represented by type2 immune response, characterized by eosinophilic infiltration. This article is protected by copyright. All rights reserved...
February 5, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30723957/ptx3-and-d-dimer-in-children-with-asthma-a-real-world-study-reply
#10
LETTER
Pengfei Gao, Jianping Zhao, Jungang Xie
Licari and colleagues detected plasma pentraxin 3 (PTX3) and serum D-dimer levels, and reported significant elevated concentrations for both biomarkers in asthmatic patients compared with healthy controls, but neither was observed to be associated with clinical parameters. Elevated PTX3 expressions in asthmatic airways were firstly observed by Zhang et al,1 and the same group reported that PTX3 deletion enhanced airway inflammation, mucus production, and airway hyperresponsiveness in an ovalbumin-induced asthma model through a TH17-dominant phenotype...
February 5, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30716182/levels-of-horse-allergen-equ-c-4-in-dander-and-saliva-from-ten-horse-breeds
#11
Susanne Victor, Jonas Binnmyr, Erik Lampa, Anna Rask-Andersen, Lena Elfman
BACKGROUND: Horses are an important source of allergens, but the distribution of horse allergens is poorly understood. Five horse allergens have been identified, Equ c 1-4 and 6. Equ c 4 seems to be an important allergen, with an IgE-binding frequency of 77% in horse-sensitized individuals. OBJECTIVES: The aim of this study was to investigate levels of horse allergen Equ c 4 in dander, saliva and urine from ten horse breeds. METHOD: The study population included 170 horses (87 mares, 27 stallions, 56 geldings) from ten breeds...
February 4, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30714219/food-avoidance-strategies-in-eosinophilic-oesophagitis
#12
Antonella Cianferoni, Michelle Shuker, Terri Brown-Whitehorn, Hannah Hunter, Carina Venter, Jonathan M Spergel
EoE is a chronic disease associated with significant morbidity that can result in permanent fibrosis and stricture formation. Given the complexity a multidisciplinary approach is recommended to manage these patients. In the majority of children with EoE not responsive to proton pump inhibitors (PPI), inflammation is driven by sensitivity to foods and treatment with an elimination diet can be effective. Foods most commonly identified to trigger EoE in children are milk and wheat, but egg, soy, meats and grains can also be triggers...
February 3, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30710420/goblet-cell-hyperplasia-as-a-feature-of-neutrophilic-asthma
#13
Khuder Alagha, Arnaud Bourdin, Charlotte Vernisse, Céline Garulli, Céline Tummino, Jérémy Charriot, Isabelle Vachier, Carey Suehs, Pascal Chanez, Delphine Gras
BACKGROUND: Goblet Cell Hyperplasia (GCH) is a pathological finding classically reported across asthma severity levels and usually associated with smoking. Multiple biological mechanisms may contribute to excessive mucus production. OBJECTIVE: We aimed to decipher the clinical meanings and biological pathways related to GCH in non smokers with asthma. METHODS: Cough And Sputum Assessment Questionnaire (CASA-Q) responses at entry and one year later were compared to clinical and functional outcomes in 59 asthmatic patients...
February 1, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30706562/quality-and-potency-profile-of-eight-recombinant-isoallergens-largely-mimicking-total-bet-v-1-specific-ige-binding-of-birch-pollen
#14
Christian Seutter von Loetzen, Andreas Reuter, Jelena Spiric, Thomas Schulenborg, Iris Bellinghausen, Elke Völker, Lothar Vogel, Paul Rösch, Dirk Schiller
BACKGROUND: To date only limited information on structure, expression levels and IgE binding of Bet v 1 variants, which are simultaneously expressed in birch pollen, is available. OBJECTIVE: To analyze and compare structure and serum IgE/IgG binding of rBet v 1 variants to Bet v 1.0101. METHODS: Recombinant Bet v 1 variants were studied with sera of 20 subjects allergic to birch pollen. Folding, aggregation and solubility of the rBet v 1 variants was analyzed to attribute diverging IgE binding to either allergen structure or methodological features...
January 31, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30706545/seed-storage-2s-albumins-are-predictive-indicators-of-exclusive-anacardiaceae-cross-reactivity
#15
LETTER
Cristina Bueno-Díaz, Laura Martín-Pedraza, Sara Benedé, Elisa Haroun-Díaz, Manuel de Las Heras, Eva Batanero, Javier Cuesta-Herranz, Mayte Villalba
Pistachio (Pistachio vera) and cashew nut (Anacardium occidentale), members of the Anacardiaceae family, account for a significant percentage of food allergies worldwide [1]. Nuts are one of the main causes of food anaphylaxis, eliciting a significant number of life-threatening reactions, which are aggravated by the fact that these allergens are often hidden in processed foods. Variability of allergic phenotypes to nut allergens with complex cross-reactivity profiles complicates clinical management of the patient [2]...
January 31, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30697902/genome-wide-association-study-of-inhaled-corticosteroid-response-in-admixed-children-with-asthma
#16
N Hernandez-Pacheco, N Farzan, B Francis, L Karimi, K Repnik, S J Vijverberg, P Soares, M Schieck, M Gorenjak, E Forno, C Eng, S S Oh, L Pérez-Méndez, V Berce, R Tavendale, L A Samedy, S Hunstman, D Hu, K Meade, H J Farber, P C Avila, D Serebrisky, S M Thyne, E Brigino-Buenaventura, W Rodriguez-Cintron, S Sen, R Kumar, M Lenoir, J R Rodriguez-Santana, J C Celedón, S Mukhopadhyay, U Potočnik, M Pirmohamed, K M Verhamme, M Kabesch, C N A Palmer, D B Hawcutt, C Flores, A H Maitland van der Zee, E G Burchard, M Pino-Yanes
BACKGROUND: Inhaled corticosteroids (ICS) are the most widely prescribed and effective medication to control asthma symptoms and exacerbations. However, many children still have asthma exacerbations despite treatment, particularly in admixed populations, such as Puerto Ricans and African Americans. A few genome-wide association studies (GWAS) have been performed in European and Asian populations, and they have demonstrated the importance of the genetic component in ICS response. OBJECTIVE: We aimed to identify genetic variants associated with asthma exacerbations in admixed children treated with ICS, and to validate previous GWAS findings...
January 29, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30697845/characterization-of-sensitization-to-furry-animal-allergen-components-in-an-adult-population
#17
Shintaro Suzuki, Bright I Nwaru, Linda Ekerljung, Sigrid Sjölander, Roxana Mincheva, Erik P Rönmark, Eva Rönmark, Bo Lundbäck, Magnus P Borres, Jan Lötvall
BACKGROUND: There are paucity of data on sensitization to furry animal allergen components in adults. Furry animals are major sensitizers and contributors to asthma burden in northern Europe and North America. OBJECTIVE: To characterize sensitization patterns to furry animal allergen components in Swedish adults. METHODS: Based on the West Sweden Asthma Study, a random population (n=1103) and an asthma sample (n=769) were tested for allergen sensitization using Phadiatop® ...
January 29, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30693574/incidental-pharmacogenetics-findings-in-an-hla-related-research-considerations-for-primary-prevention
#18
LETTER
Faizal Bakhtiar, Chun-Lai Too, Min-Moon Tang, Salsabil Sulaiman, Lay-Kim Tan, Nurul Aain Ahmad-Fauzi, Fan-Yin Kwok, Shahnaz Murad, Giriyappanavar Chandrashekar Rayyapa
Hypersensitivity drug reactions (HDRs) are an immense public health problem where significant proportions may lead to mortality. HDRs can manifest in various phenotypes, mainly cutaneous reactions that range from the mild; i.e. exanthem, urticaria, and angioedema to the critical; i.e. severe cutaneous adverse reactions (SCARs). SCARs are life-threatening reactions that include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) and less commonly, acute generalized exanthematous pustulosis (AGEP)...
January 28, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30689281/dietary-fats-olive-oil-and-respiratory-diseases-in-italian-adults-a-population-based-study
#19
Lucia Cazzoletti, Maria Elisabetta Zanolin, Francesco Spelta, Roberto Bono, Liliya Chamitava, Isa Cerveri, Vanessa Garcia-Larsen, Amelia Grosso, Veronica Mattioli, Pietro Pirina, Marcello Ferrari
BACKGROUND: Fat intake has been associated with respiratory diseases, with conflicting results. OBJECTIVE: We studied the association between asthma and rhinitis with dietary fats, and their food sources in an Italian population. METHODS: Clinical and nutritional information was collected for 871 subjects (aged 20-84) from the population-based multi-case control study Genes Environment Interaction in Respiratory Diseases (GEIRD): 145 with Current Asthma (CA), 77 with Past Asthma (PA), 305 with Rhinitis and 344 Controls...
January 28, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30689269/angiopoietin-1-haploinsufficiency-affects-the-endothelial-barrier-and-causes-hereditary-angioedema
#20
Maria d'Apolito, Rosa Santacroce, Anna Laura Colia, Giorgia Cordisco, Angela Bruna Maffione, Maurizio Margaglione
BACKGOUND: Different mutations of the angiopoietin-1 gene (ANGPT1) have been associated with the occurrence of Hereditary Angioedema (HAE). OBJECTIVE: The purpose of the study is to clarify whether the ANGPT1 A119S variant plays its role via haploinsufficiency or a dominant negative effect. METHODS: The ability of ANGPT1 A119S variant to affect the endothelial barrier function was assessed by immunocytochemistry. Inter-endothelial gap formation molecules primarily responsible for cell-cell adhesions of HUVECs, vascular endothelial (VE)-cadherin and β-catenin, and reorganization of the F-actin cytoskeletal were evaluated...
January 28, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
journal
journal
20071
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"