journal
https://read.qxmd.com/read/38639267/increased-serpinb2-potentiates-15lo1-expression-via-stat6-signalling-in-epithelial-cells-in-eosinophilic-chronic-rhinosinusitis-with-nasal-polyps
#1
JOURNAL ARTICLE
Chunyu Luo, Ying Zhu, Shiyao Zhang, Jiayao Zhou, Song Mao, Ru Tang, Yuelong Gu, Shaolin Tan, Hai Lin, Zhipeng Li, Weitian Zhang
BACKGROUND: SERPINB2, a biomarker of Type-2 (T2) inflammatory processes, has been described in the context of asthma. Chronic rhinosinusitis with nasal polyps (CRSwNP) is also correlated with T2 inflammation and elevated 15LO1 induced by IL-4/13 in nasal epithelial cells. The aim of this study was to evaluate the expression and location of SERPINB2 in nasal epithelial cells (NECs) and determine whether SERPINB2 regulates 15LO1 and downstream T2 markers in NECs via STAT6 signalling. METHODS: SERPINB2 gene expression in bulk and single-cell RNAseq database was analysed by bioinformatics analysis...
April 19, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38616622/clinical-validation-of-grass-pollen-exposure-chamber-in-patients-with-allergic-rhinitis-triggered-by-timothy-grass
#2
JOURNAL ARTICLE
Anna Kosowska, Magdalena Zemelka-Wiącek, Sylwia Smolińska, Ewa Wyrodek, Bartosz Adamczak, Marek Jutel
BACKGROUND: The fluctuation in concentrations of airborne allergens frequently presents a challenge to assessing the efficacy of allergen immunotherapy (AIT) in 'field' studies. Allergen exposure chambers (AECs) are specialized medical installations developed to expose individuals to allergens at defined and consistent concentrations under a controlled environment. The aim of the study was to validate the provocation test with timothy grass pollen as well as to assess its safety in the AEC in patients with allergic rhinitis...
April 14, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38616294/mediterranean-type-diet-in-school-age-in-relation-to-asthma-and-lung-function-up-to-young-adulthood
#3
JOURNAL ARTICLE
Athina V Georgakou, Sandra Ekström, Niklas Andersson, Jenny Hallberg, Alicja Wolk, Niklas Håkansson, Antonios Georgelis, Erik Melén, Inger Kull, Emmanouela Sdona, Anna Bergström
No abstract text is available yet for this article.
April 14, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38576214/do-psychological-interventions-improve-outcomes-for-asthma-in-children-and-young-people
#4
JOURNAL ARTICLE
Emine Nebati
No abstract text is available yet for this article.
April 4, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38567657/english-tweets-on-allergy-content-analysis-and-association-with-surveillance-data
#5
JOURNAL ARTICLE
Bernardo Sousa-Pinto, Slava Jankin, Rafael José Vieira, Manuel Marques-Cruz, João Almeida Fonseca, Jean Bousquet
BACKGROUND: Analysis of X (formerly Twitter) posts can inform on the interest/perceptions that social media users have on health subjects. In this study, we aimed to analyse tweets on allergic conditions, comparing them with surveillance data. METHODS: We retrieved tweets from England on "allergy," "asthma," and "allergic rhinitis," published between 2016 and 2021. We estimated the correlation between the frequency of tweets on "asthma" and "allergic rhinitis" and English surveillance data on the incidence of asthma and allergic rhinitis medical visits...
April 3, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38556721/an-integrated-molecular-risk-score-early-in-life-for-subsequent-childhood-asthma-risk
#6
JOURNAL ARTICLE
Andreas Böck, Kathrin Urner, Jana Kristin Eckert, Michael Salvermoser, Kristina Laubhahn, Sonja Kunze, Jörg Kumbrink, Marc P Hoeppner, Kathrin Kalkbrenner, Simone Kreimeier, Kirsten Beyer, Eckard Hamelmann, Michael Kabesch, Martin Depner, Gesine Hansen, Josef Riedler, Marjut Roponen, Elisabeth Schmausser-Hechfellner, Cindy Barnig, Amandine Divaret-Chauveau, Anne M Karvonen, Juha Pekkanen, Remo Frei, Caroline Roduit, Roger Lauener, Bianca Schaub
BACKGROUND: Numerous children present with early wheeze symptoms, yet solely a subgroup develops childhood asthma. Early identification of children at risk is key for clinical monitoring, timely patient-tailored treatment, and preventing chronic, severe sequelae. For early prediction of childhood asthma, we aimed to define an integrated risk score combining established risk factors with genome-wide molecular markers at birth, complemented by subsequent clinical symptoms/diagnoses (wheezing, atopic dermatitis, food allergy)...
March 31, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38545699/efficacy-of-300-ir-house-dust-mite-immunotherapy-as-a-function-of-disease-activity-tertile-analysis-in-clinical-trials
#7
JOURNAL ARTICLE
Philippe Devillier, Pascal Demoly, Catherine Gentil, Karl-Christian Bergmann, Thomas B Casale, Yoshitaka Okamoto, Oliver Pfaar
BACKGROUND: The symptoms of house dust mite (HDM)-induced allergic rhinitis (AR) vary with changes in exposure related to the weather or the domestic environment. In allergen immunotherapy (AIT) studies, a certain level of AR disease activity is necessary to demonstrate treatment efficacy; the latter can be underestimated if a substantial proportion of the patient population is weakly symptomatic. OBJECTIVE: To better estimate the real treatment effect of a HDM sublingual AIT (SLIT) tablet, we analysed the results of natural field studies in detail by applying a tertile approach...
March 28, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38499494/exploring-facilitators-and-barriers-in-asthma-management-in-rural-semi-urban-and-urban-populations-in-vellore-india-an-interview-study-of-patients-and-primary-care-physicians
#8
JOURNAL ARTICLE
Iestyn Williams, Jefferson Daniel, Adel H Mansur, Devasahayam Jesudas Christopher, Mamidipudi Thirumala Krishna
No abstract text is available yet for this article.
March 18, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38499330/are-skin-tests-useful-after-benign-immediate-reactions-to-beta-lactams-in-children
#9
JOURNAL ARTICLE
Bouchra Mahjoub, Charlotte Marsac, Claude Ponvert, Christophe Delacourt, Hassan Faour, Nicolas Garcelon, Guillaume Lezmi
No abstract text is available yet for this article.
March 18, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38494591/asthma-outcomes-inhaled-corticosteroid-adherence-and-socio-economic-deprivation-in-english-regions
#10
JOURNAL ARTICLE
Haania Hussain, Tricia M McKeever, Sherif Gonem
No abstract text is available yet for this article.
March 17, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38488340/adverse-drug-reactions-from-adrenaline-auto-injectors-data-from-the-french-poison-control-centres
#11
JOURNAL ARTICLE
Guillaume Pouessel, Christine Tournoud, Sophie Gautier, Patrick Nisse, Luciana Kase Tanno
No abstract text is available yet for this article.
March 15, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38488190/adherence-to-adrenaline-autoinjector-prescriptions-in-patients-with-severe-food-allergy
#12
JOURNAL ARTICLE
Sebastian Vigand Svendsen, Annemarie Schaeffer Senders, Athamaica Ruiz Oropeza, Annmarie Lassen, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen, Charlotte G Mortz
No abstract text is available yet for this article.
March 15, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38475973/component-specific-clusters-for-diagnosis-and-prediction-of-allergic-airway-diseases
#13
JOURNAL ARTICLE
Rebecca Howard, Sara Fontanella, Angela Simpson, Clare S Murray, Adnan Custovic, Magnus Rattray
BACKGROUND: Previous studies which applied machine learning on multiplex component-resolved diagnostics arrays identified clusters of allergen components which are biologically plausible and reflect the sources of allergenic proteins and their structural homogeneity. Sensitization to different clusters is associated with different clinical outcomes. OBJECTIVE: To investigate whether within different allergen component sensitization clusters, the internal within-cluster sensitization structure, including the number of c-sIgE responses and their distinct patterns, alters the risk of clinical expression of symptoms...
March 12, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38470356/association-between-long-term-occupational-exposure-to-pm-10-and-allergic-diseases-in-subway-workers
#14
JOURNAL ARTICLE
Romain Freund, Jean-Jacques Sauvain, Guillaume Suarez, Pascal Wild, Thomas Charreau, Jacques A Pralong, Amélie Debatisse, Valérie Jouannique, Kirushanthi Sakthithasan, Irina Guseva Canu
No abstract text is available yet for this article.
March 12, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38467536/phosphoinositide-3-kinase-activity-in-severe-eosinophilic-asthma-with-recurrent-airway-infections-and-neutrophilic-exacerbations
#15
JOURNAL ARTICLE
Anurag Bhalla, Katherine Radford, Kiho Son, Kayla Zhang, Chynna Huang, Melanie Kjarsgaard, Nicola LaVigne, Zachary Brautigam, Sarah Svenningsen, Guillaume Paré, Manali Mukherjee, Parameswaran Nair
No abstract text is available yet for this article.
March 11, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38462790/risk-factors-for-sulfamethoxazole-trimethoprim-induced-severe-cutaneous-adverse-reactions
#16
JOURNAL ARTICLE
Kanokkarn Pinyopornpanish, Apinya Chungcharoenpanich, Putthapon Teepapan, Kunlawat Thadanipon, Chulapha Ruangwattanachok, Pansa Lamrahong, Nattakirana Thongdee, Nizchapa Dechapaphapitak, Chonlaphat Sukasem, Chanamon Pongphaew, Thawinee Jantararoungtong, Napatrupron Koomdee, Wannada Laisuan
No abstract text is available yet for this article.
March 10, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38462778/babybathe-study-protocol-a-randomised-controlled-feasibility-trial-to-change-baby-bathing-practice-during-the-first-months-of-life
#17
JOURNAL ARTICLE
Michael R Perkin, Michael Ussher, Lucy P Goldsmith, Carsten Flohr, Amanda Roberts, Victoria Cornelius, Charlotte Wahlich, Kathryn Willis, Robert J Boyle
No abstract text is available yet for this article.
March 10, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38456230/correction-to-eosinophil-derived-neurotoxin-levels-in-early-childhood-and-association-with-preschool-asthma-a-prospective-observational-study
#18
(no author information available yet)
No abstract text is available yet for this article.
March 8, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38456221/factors-associated-with-venom-immunotherapy-side-effects-re-sting-reactions-and-adherence-in-real-life
#19
JOURNAL ARTICLE
Louise Parke, Henrik Fomsgaard Kjaer, Susanne Halken, Carsten Bindslev-Jensen, Charlotte G Mortz
No abstract text is available yet for this article.
March 8, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38423799/optimising-the-management-of-peanut-allergy-by-targeting-immune-plasticity
#20
REVIEW
Alan Nguyen, George du Toit, Gideon Lack, Tom Marrs
Randomised controlled trials investigating the efficacy of oral tolerance induction to peanut have enabled detailed comparison of their clinical and immunological success. They have demonstrated that the regular consumption of peanut for at least 2 years by babies who are not allergic enables protection from developing peanut allergy. The LEAP study intervention tested the impact of regular peanut consumption for 4 years and demonstrated a sustained protection against the development of peanut allergy even after 12 months of peanut avoidance from 5 to 6 years of age...
February 29, 2024: Clinical and Experimental Allergy
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