Jamie S Ostroff, Kemi L Bolutayo Gaffney, Maureen O'Brien, Suhana T deLeon-Sanchez, C Will Whitlock, Chris S Kotsen, Lisa Carter-Harris, Smita C Banerjee, Elizabeth Schofield
BACKGROUND: Clinical practice guidelines for promoting smoking cessation in cancer care exist; however, most oncology settings have not established tobacco use assessment and treatment as standard care. Inadequate staff training and other implementation challenges have been identified as barriers for delivery of evidence-based tobacco treatment. Providing training in tobacco treatment tailored to the unique needs of tobacco-dependent patients with cancer is one strategy to improve adoption of best practices to promote smoking cessation in cancer care...
April 29, 2021: Cancer
Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Koji Sasaki, Lucia Masarova, Kiran Naqvi, Elias Jabbour, Courtney D DiNardo, Koichi Takahashi, Marina Konopleva, Naveen Pemmaraju, Tapan M Kadia, Farhad Ravandi, Naval Daver, Gautam Borthakur, Zeev Estrov, Joseph D Khoury, Sanam Loghavi, Kelly A Soltysiak, Sherry Pierce, Carlos Bueso-Ramos, Keyur P Patel, Srdan Verstovsek, Hagop M Kantarjian, Prithviraj Bose, Guillermo Garcia-Manero
BACKGROUND: There are limited data on the clonal mechanisms underlying leukemogenesis, prognostic factors, and optimal therapy for atypical chronic myeloid leukemia (aCML). METHODS: The authors evaluated the clinicopathologic features, outcomes, and responses to therapy of 65 patients with aCML. The median age was 67 years (range, 46-89 years). RESULTS: The most frequently mutated genes included ASXL1 (83%), SRSF2 (68%), and SETBP1 (58%). Mutations in SETBP1, SRSF2, TET2, and GATA2 appeared at variant allele frequencies (VAFs) greater than 40%, whereas other RAS pathway mutations were more likely to appear at low VAFs...
April 29, 2021: Cancer
Mayuko Iijima, Wei Liu, John C Panetta, Melissa M Hudson, Ching-Hon Pui, Deo Kumar Srivastava, Kevin R Krull, Hiroto Inaba
BACKGROUND: Neurocognitive impairment and obesity are common adverse sequelae in survivors of childhood acute lymphoblastic leukemia (ALL); however, the association has not been investigated. METHODS: Neurocognitive function was evaluated once in survivors of ALL who were at least 8 years old and 5 years from their diagnosis. In a cross-sectional analysis, the associations with the body mass index (BMI) category and Z score were examined. A longitudinal analysis used the overweight/obesity area under the curve (AUC), which was determined via the trapezoidal rule by a sum of the integrals defined by the BMI Z score at each time point and the time intervals of the BMI measurement...
April 29, 2021: Cancer
Silvia Stacchiotti, Anna Maria Frezza, Jean-Yves Blay, Elizabeth H Baldini, Sylvie Bonvalot, Judith V M G Bovée, Dario Callegaro, Paolo G Casali, RuRu Chun-Ju Chiang, George D Demetri, Elisabeth G Demicco, Jayesh Desai, Mikael Eriksson, Hans Gelderblom, Suzanne George, Mrinal M Gounder, Alessandro Gronchi, Abha Gupta, Rick L Haas, Andrea Hayes-Jardon, Peter Hohenberger, Kevin B Jones, Robin L Jones, Bernd Kasper, Akira Kawai, David G Kirsch, Eugene S Kleinerman, Axel Le Cesne, Jiwon Lim, María Dolores Chirlaque López, Roberta Maestro, Rafael Marcos-Gragera, Javier Martin Broto, Tomohiro Matsuda, Olivier Mir, Shreyaskumar R Patel, Chandrajit P Raut, Albiruni R A Razak, Damon R Reed, Piotr Rutkowski, Roberta G Sanfilippo, Marta Sbaraglia, Inga-Marie Schaefer, Dirk C Strauss, Kirsten Sundby Hall, William D Tap, David M Thomas, Winette T A van der Graaf, Winan J van Houdt, Otto Visser, Margaret von Mehren, Andrew J Wagner, Breelyn A Wilky, Young-Joo Won, Christopher D M Fletcher, Angelo P Dei Tos, Annalisa Trama
BACKGROUND: Among sarcomas, which are rare cancers, many types are exceedingly rare; however, a definition of ultra-rare cancers has not been established. The problem of ultra-rare sarcomas is particularly relevant because they represent unique diseases, and their rarity poses major challenges for diagnosis, understanding disease biology, generating clinical evidence to support new drug development, and achieving formal authorization for novel therapies. METHODS: The Connective Tissue Oncology Society promoted a consensus effort in November 2019 to establish how to define ultra-rare sarcomas through expert consensus and epidemiologic data and to work out a comprehensive list of these diseases...
April 28, 2021: Cancer
Ahmed S Abdelmeguid, Natalie L Silver, Mongkol Boonsripitayanon, Bonnie S Glisson, Renata Ferrarotto, G Brandon Gunn, Jack Phan, Ann M Gillenwater, Ehab Y Hanna
BACKGROUND: Patients with locoregionally advanced oral cavity squamous cell carcinoma (OCSCC) have a poor survival outcome. Treatment involves extensive surgery, adjuvant radiation, or chemoradiation and results in high morbidity. In this study, the authors' objective was to evaluate their experience with induction chemotherapy (IC) in the treatment of locoregionally advanced OCSCC. METHODS: A retrospective review of the medical records of all patients with locoregionally advanced (stage III and IV) OCSCC who received IC followed by definitive local therapy was conducted...
April 28, 2021: Cancer
Desiree R Azizoddin, Robert Knoerl, Rosalind Adam, Daniela Kessler, James A Tulsky, Robert R Edwards, Andrea C Enzinger
BACKGROUND: The US opioid epidemic has prompted dramatic changes in public attitudes and regulations governing opioid prescribing. Little is known about the experiences of patients with advanced cancer using opioids in the context of the epidemic. METHODS: Semistructured interviews of 26 patients with advanced cancer were conducted between May 2019 and April 2020; their experiences self-managing chronic pain with opioids were evaluated. RESULTS: Patients consistently described the negative impact of the opioid epidemic on their ability to self-manage pain...
April 27, 2021: Cancer
Alizé A Rogge, Stefanie M Helmer, Ryan King, Claudia Canella, Katja Icke, Daniel Pach, Claudia M Witt
BACKGROUND: Many patients with cancer do not disclose complementary medicine use but want their physician's advice on this matter. This study evaluated whether using blended learning (e-learning plus a workshop) to train oncology physicians in providing advice on complementary and integrative medicine (CIM) therapies to their patients with cancer, in addition to distributing an information leaflet on reputable CIM websites, had different effects on patient-reported outcomes for the consultation than only distributing the leaflet...
April 27, 2021: Cancer
Santino S Butler, Brandon A Mahal, Javid J Moslehi, Anju Nohria, Edward C Dee, Rishi Makkar, Amanda Whitbeck, Janet Wangoe, Kent W Mouw, Paul L Nguyen, Vinayak Muralidhar
BACKGROUND: For men with radiation-managed prostate cancer, there is conflicting evidence regarding the association between androgen deprivation therapy (ADT) and cardiovascular mortality (CVM), particularly among those who have with preexisting comorbidities. The objective of this study was to analyze the association between ADT and CVM across patient comorbidity status using prospectively collected data from a large clinical trial. METHODS: In total, 1463 men were identified who were diagnosed with clinically localized, intermediate-risk/high-risk prostate cancer (T2b-T4, Gleason 7-10, or prostate-specific antigen >10 ng/mL) from 1993 to 2001 and managed with either radiation therapy (RT) alone or RT plus ADT during the randomized Prostate, Lung, Colon, and Ovarian (PLCO) Cancer Screening Trial...
April 27, 2021: Cancer
Kemal Caglar Gogebakan, Kumar Mukherjee, Elizabeth G Berry, Kemal Sonmez, Sancy A Leachman, Ruth Etzioni
BACKGROUND: Since 2011, the therapeutic landscape of melanoma has changed dramatically because of the adoption of immune checkpoint inhibitor and targeted therapies. The authors sought to quantify the effects of these changes on short-term treatment costs by comparing the first-year cancer-attributable costs in novel (2011-2015) and historical (2004-2010) treatment eras. METHODS: The authors estimated the first-year cancer-attributable and out-of-pocket (OOP) costs by cancer stage at diagnosis by using a case-control approach...
April 27, 2021: Cancer
Christine Miaskowski, Steven M Paul, Karin Snowberg, Maura Abbott, Hala T Borno, Susan M Chang, Lee May Chen, Bevin Cohen, Bruce A Cooper, Marilyn J Hammer, Stacey A Kenfield, Kord M Kober, Angela Laffan, Jon D Levine, Rachel Pozzar, Kim Rhoads, Katy K Tsai, Erin L Van Blarigan, Katherine Van Loon
BACKGROUND: Loneliness and social isolation are significant public health problems that are being exacerbated during the coronavirus disease 2019 pandemic. Little is known about the associations between loneliness and symptom burden in oncology patients before and during the pandemic. Study purposes include determining the prevalence of loneliness in a sample of oncology patients; evaluating for differences in demographic, clinical, and symptom characteristics between lonely and nonlonely patients; and determining which demographic, clinical, and symptom characteristics were associated with membership in the lonely group...
April 27, 2021: Cancer
Dany Habr, Roxanne Ferdinand
No abstract text is available yet for this article.
April 27, 2021: Cancer
Yiting Stefanie Chen, Zhen Ni Zhou, Shannon M Glynn, Melissa K Frey, Onyinye D Balogun, Margaux Kanis, Kevin Holcomb, Constantine Gorelick, Charlene Thomas, Paul J Christos, Eloise Chapman-Davis
BACKGROUND: New York City (NYC) emerged as an epicenter of the novel coronavirus disease 2019 (COVID-19) pandemic, and marginalized populations were affected at disproportionate rates. The authors sought to determine the impact of COVID-19 on cancer treatment, anxiety, and financial distress among low-income patients with gynecologic cancer during the peak of the NYC pandemic. METHODS: Medicaid-insured women who were receiving gynecologic oncology care at 2 affiliated centers were contacted by telephone interviews between March 15 and April 15, 2020...
April 26, 2021: Cancer
Olivia S Allen, Nina Kim, Jose Morillo, Cardinale B Smith
BACKGROUND: Prior studies reveal a lack of illness understanding and prognostic awareness among patients with hematologic malignancies. Prognostic awareness and illness understanding among hospitalized patients with acute leukemia and multiple myeloma were evaluated, and patient-oncologist discordance was measured. METHODS: Patients with acute leukemia and multiple myeloma hospitalized at Mount Sinai Hospital between February 2018 and February 2020 were enrolled...
April 23, 2021: Cancer
Maresa C Woodfield, Steven A Pergam, Parth D Shah
No abstract text is available yet for this article.
April 23, 2021: Cancer
Omer H Jamy, Richard Godby, Aditi Dhir, Luciano J Costa, Ana C Xavier
BACKGROUND: Survival among patients diagnosed with acute promyelocytic leukemia (APL) has significantly improved with the use of all-trans retinoic acid and arsenic trioxide. However, the need for immediate diagnosis and access to specialized care and the cost associated with APL management can potentially act as barriers for disadvantaged patients. The influence of sociodemographic factors on the outcomes of patients with APL remains unclear. METHODS: The authors used the National Cancer Institute's Surveillance, Epidemiology, and End Results program to characterize the impact of sociodemographic factors on survival in patients younger than 65 years with APL...
April 23, 2021: Cancer
Naveen Pemmaraju
No abstract text is available yet for this article.
April 23, 2021: Cancer
Antonio Di Meglio, Arnauld S Gbenou, Elise Martin, Barbara Pistilli, Jennifer A Ligibel, Tracy E Crane, Jean-Daniel Flaysakier, Etienne Minvielle, Laurence Vanlemmens, Charles Guenancia, Olivier Rigal, Marion Fournier, Patrick Soulie, Marie-Ange Mouret-Reynier, Carole Tarpin, Florence Boiffard, Sophie Guillermet, Sibille Everhard, Anne-Laure Martin, Sylvie Giacchetti, Thierry Petit, Florence Dalenc, Philippe Rouanet, Antoine Arnaud, Fabrice Andre, Ines Vaz-Luis
BACKGROUND: This study assessed the prevalence and risk factors of unhealthy behaviors among survivors of early-stage breast cancer. METHODS: Women (n = 9556) from the CANcer TOxicity cohort (NCT01993498) were included. Physical activity (PA), tobacco and alcohol consumption, and body mass index were assessed at diagnosis and at years 1 and 2 after diagnosis. A behavior was defined as unhealthy if patients failed to meet PA recommendations (≥10 metabolic equivalent task hours per week), reduce/quit tobacco, or decrease alcohol consumption to less than daily, or if they gained substantial weight over time...
April 22, 2021: Cancer
Tal Sella, Philip D Poorvu, Kathryn J Ruddy, Shari I Gelber, Rulla M Tamimi, Jeffrey M Peppercorn, Lidia Schapira, Virginia F Borges, Steven E Come, Ann H Partridge, Shoshana M Rosenberg
BACKGROUND: The diagnosis and treatment of breast cancer can have profound effects on a young woman's family planning and fertility, particularly among women with hormone receptor-positive breast cancer. METHODS: The Young Women's Breast Cancer Study was a multicenter cohort of women aged 40 years or younger and newly diagnosed with breast cancer from 2006 to 2016. Surveys included assessments of fertility concerns, endocrine therapy (ET) preferences, and use. Characteristics were compared between women who reported that fertility concerns affected ET decisions and those who did not...
April 22, 2021: Cancer
Caitlin E Taylor, Jane Lowe Meisel
No abstract text is available yet for this article.
April 22, 2021: Cancer
Joseph E Bauer
No abstract text is available yet for this article.
April 21, 2021: Cancer
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