journal
https://read.qxmd.com/read/34328216/presentation-patterns-of-care-and-outcomes-of-patients-with-prostate-cancer-in-sub-saharan-africa-a-population-based-registry-study
#1
Tobias Paul Seraphin, Walburga Yvonne Joko-Fru, Lucia Hämmerl, Mirko Griesel, Nikolaus Christian Simon Mezger, Jana Cathrin Feuchtner, Innocent Adoubi, Marcel Dieu-Donné Egué, Nathan Okerosi, Henry Wabinga, Rolf Hansen, Samukeliso Vuma, Cesaltina Lorenzoni, Bourama Coulibaly, Sévérin W Odzebe, Nathan Gyabi Buziba, Abreha Aynalem, Biying Liu, Daniel Medenwald, Rafael T Mikolajczyk, Jason Alexander Efstathiou, Donald Maxwell Parkin, Ahmedin Jemal, Eva Johanna Kantelhardt
BACKGROUND: Although prostate cancer (PCa) is the most commonly diagnosed cancer in men of sub-Saharan Africa (SSA), little is known about its management and survival. The objective of the current study was to describe the presentation, patterns of diagnosis, treatment, and survival of patients with PCa in 10 countries of SSA. METHODS: In this observational registry study with data collection from 2010 to 2018, the authors drew a random sample of 738 patients with PCa who were registered in 11 population-based cancer registries...
July 30, 2021: Cancer
https://read.qxmd.com/read/34328212/the-state-of-our-understanding-of-prostate-cancer-in-sub-saharan-africa
#2
EDITORIAL
Scott A Greenberg, Samuel L Washington
No abstract text is available yet for this article.
July 30, 2021: Cancer
https://read.qxmd.com/read/34324708/fbxw7-l1cam-and-tgm2-in-endometrial-cancer
#3
LETTER
Steven Lehrer, Peter H Rheinstein
No abstract text is available yet for this article.
July 29, 2021: Cancer
https://read.qxmd.com/read/34324707/cancer-patterns-in-nasopharyngeal-carcinoma-multiplex-families-over-15-years
#4
Kelly J Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
BACKGROUND: Genetic and environmental factors are important determinants of nasopharyngeal carcinoma (NPC). NPC is associated with Epstein-Barr virus (EBV) infection. Studies have reported familial aggregation of NPC, but evidence has been mixed for elevated rates of cancers other than NPC. METHODS: The authors reassessed their previous evaluation of familial aggregation of cancer in 348 high-risk Taiwanese multiplex families with 2 or more NPC cases enrolled between 1980 and 2003...
July 29, 2021: Cancer
https://read.qxmd.com/read/34324196/reply-to-fbxw7-l1cam-and-tgm2-in-endometrial-cancer
#5
LETTER
Mary Ellen Urick, Eun-Jeong Yu, Daphne W Bell
No abstract text is available yet for this article.
July 29, 2021: Cancer
https://read.qxmd.com/read/34314028/survival-analysis-and-treatment-effects-in-patients-with-endometrial-cancer-and-pole-mutations
#6
LETTER
Simon Lamothe, Maximiliano Ramia de Cap
No abstract text is available yet for this article.
July 27, 2021: Cancer
https://read.qxmd.com/read/34314024/reply-to-survival-analysis-and-treatment-effects-in-patients-with-endometrial-cancer-and-pole-mutations
#7
LETTER
Aline Talhouk, Jessica N McAlpine
No abstract text is available yet for this article.
July 27, 2021: Cancer
https://read.qxmd.com/read/34314022/weight-loss-does-not-decrease-risk-of-breast-cancer-related-arm-lymphedema
#8
Sacha A Roberts, Tessa C Gillespie, Amy M Shui, Cheryl L Brunelle, Kayla M Daniell, Joseph J Locascio, George E Naoum, Alphonse G Taghian
BACKGROUND: The goal of this study was to determine the relationship between postoperative weight change and breast cancer-related lymphedema (BCRL). METHODS: In this cohort study, 1161 women underwent unilateral breast surgery for breast cancer from 2005 to 2020 and were prospectively screened for BCRL. Arm volume measurements were obtained via an optoelectronic perometer preoperatively, postoperatively, and in the follow-up setting every 6 to 12 months. Mean follow-up from preoperative baseline was 49...
July 27, 2021: Cancer
https://read.qxmd.com/read/34314018/longer-term-outcomes-with-single-agent-belantamab-mafodotin-in-patients-with-relapsed-or-refractory-multiple-myeloma-13-month-follow-up-from-the-pivotal-dreamm-2-study
#9
Sagar Lonial, Hans C Lee, Ashraf Badros, Suzanne Trudel, Ajay K Nooka, Ajai Chari, Al-Ola Abdallah, Natalie Callander, Douglas Sborov, Attaya Suvannasankha, Katja Weisel, Peter M Voorhees, Lynsey Womersley, January Baron, Trisha Piontek, Eric Lewis, Joanna Opalinska, Ira Gupta, Adam D Cohen
BACKGROUND: On the basis of the DREAMM-2 study (ClinicalTrials.gov identifier NCT03525678), single-agent belantamab mafodotin (belamaf) was approved for patients with relapsed or refractory multiple myeloma (RRMM) who received ≥4 prior therapies, including anti-CD38 therapy. The authors investigated longer term efficacy and safety outcomes in DREAMM-2 after 13 months of follow-up among patients who received belamaf 2.5 mg/kg. METHODS: DREAMM-2 is an ongoing, phase 2, open-label, 2-arm study investigating belamaf (2...
July 27, 2021: Cancer
https://read.qxmd.com/read/34310704/osteonecrosis-of-the-jaw-among-patients-with-cancer-treated-with-denosumab-or-zoledronic-acid-results-of-a-regulator-mandated-cohort-postauthorization-safety-study-in-denmark-norway-and-sweden
#10
Vera Ehrenstein, Uffe Heide-Jørgensen, Morten Schiødt, Olof Akre, Bente Brokstad Herlofson, Svein Hansen, Cecilia Larsson Wexell, Sven Erik Nørholt, Steinar Tretli, Anders Kjellman, Anthony Glennane, Kimberly A Lowe, Henrik T Sørensen
BACKGROUND: Osteonecrosis of the jaw (ONJ) is an adverse effect of antiresorptive treatment. This study estimated incidence proportions and incidence rates of ONJ in cancer patients with bone metastases from solid tumors treated for the prevention of skeletal-related events in routine clinical practice. METHODS: This cohort study in Denmark, Norway, and Sweden in 2011-2018 included 3 treatment cohorts: a denosumab inception cohort (DEIC), a zoledronic acid inception cohort (ZAIC), and a denosumab-switch cohort (DESC)...
July 26, 2021: Cancer
https://read.qxmd.com/read/34308557/survival-outcomes-for-cancer-types-with-the-highest-death-rates-for-adolescents-and-young-adults-1975-2016
#11
Denise Riedel Lewis, Elizabeth J Siembida, Nita L Seibel, Ashley Wilder Smith, Angela B Mariotto
BACKGROUND: Five-year relative survival for adolescent and young adult (AYA) patients with cancer diagnosed at the ages of 15 to 39 years is 85%. Survival rates vary considerably according to the cancer type. The purpose of this study was to analyze long-term survival trends for cancer types with the highest mortality among AYAs to determine where the greatest burden is and to identify areas for future research. METHODS: Using data from the Surveillance, Epidemiology, and End Results cancer registry and the National Center for Health Statistics, the authors examined the incidence, mortality, and survival for the 9 cancer types with the highest mortality rates in this age group from 1975 to 2016...
July 26, 2021: Cancer
https://read.qxmd.com/read/34297849/benefit-harm-ratio-of-the-diagnostic-workup-in-patients-with-prostate-cancer-of-gleason-score-from-9-to-10
#12
LETTER
Simona Ferraro, Roberta S Rossi, Elia M Biganzoli
No abstract text is available yet for this article.
July 23, 2021: Cancer
https://read.qxmd.com/read/34297845/reply-to-benefit-harm-ratio-of-the-diagnostic-workup-in-patients-with-prostate-cancer-and-a-gleason-score-of-9-to-10
#13
LETTER
Daniel W Kim, Derya Tilki, Anthony V D'Amico
No abstract text is available yet for this article.
July 23, 2021: Cancer
https://read.qxmd.com/read/34297360/temporal-changes-in-the-probability-of-live-birth-among-female-survivors-of-childhood-cancer-a-population-based-adult-life-after-childhood-cancer-in-scandinavia-aliccs-study-in-five-nordic-countries
#14
Sofie de Fine Licht, Kathrine Rugbjerg, Elisabeth W Andersen, Thomas T Nielsen, Filippa Nyboe Norsker, Line Kenborg, Anna S Holmqvist, Laura-Maria Madanat-Harjuoja, Laufey Tryggvadottir, Marilyn Stovall, Finn Wesenberg, Lars Hjorth, Henrik Hasle, Jeanette F Winther
BACKGROUND: During the past 4 decades, there has been a growing focus on preserving the fertility of patients with childhood cancer; however, no large studies have been conducted of live births across treatment decades during this period. Therefore, the authors estimated the potential birth deficit in female childhood cancer survivors and the probability of live births. METHODS: In total, 8886 women were identified in the 5 Nordic cancer registries in whom a childhood cancer had been diagnosed during 1954 through 2006...
July 23, 2021: Cancer
https://read.qxmd.com/read/34293201/intensity-modulated-radiation-therapy-and-doxorubicin-in-thyroid-cancer-a-prospective-phase-2-trial
#15
Paul B Romesser, Eric J Sherman, Karissa Whiting, Margaret L Ho, Ashok R Shaha, Mona M Sabra, Nadeem Riaz, Todd E Waldenberg, Christopher R Sabol, Ian Ganly, Sean M McBride, James A Fagin, Zhigang Zhang, R Michael Tuttle, Richard J Wong, Nancy Y Lee
BACKGROUND: The use of external-beam radiotherapy for locally advanced nonanaplastic thyroid cancer remains controversial. This prospective study evaluated the efficacy and tolerability of intensity-modulated radiation therapy (IMRT) with or without concurrent chemotherapy in patients with locally advanced thyroid cancer. METHODS: The authors conducted a nonrandomized phase 2 trial of IMRT with or without concurrent doxorubicin in patients with gross residual or unresectable nonanaplastic thyroid carcinoma (ClinicalTrials...
July 22, 2021: Cancer
https://read.qxmd.com/read/34292585/compliance-with-sentinel-lymph-node-biopsy-guidelines-for-invasive-melanomas-treated-with-mohs-micrographic-surgery
#16
Kelly M MacArthur, Brian C Baumann, Joseph F Sobanko, Jeremy R Etzkorn, Thuzar M Shin, H William Higgins, Cerrene N Giordano, Stacy L McMurray, Aimee Krausz, Jason G Newman, Karthik Rajasekaran, Steven B Cannady, Robert M Brody, Giorgos C Karakousis, John T Miura, Justine V Cohen, Ravi K Amaravadi, Tara C Mitchell, Lynn M Schuchter, Christopher J Miller
BACKGROUND: Sentinel lymph node biopsy (SLNB) has not been studied for invasive melanomas treated with Mohs micrographic surgery using frozen-section MART-1 immunohistochemical stains (MMS-IHC). The primary objective of this study was to assess the accuracy and compliance with National Comprehensive Cancer Network (NCCN) guidelines for SLNB in a cohort of patients who had invasive melanoma treated with MMS-IHC. METHODS: This retrospective cohort study included all patients who had primary, invasive, cutaneous melanomas treated with MMS-IHC at a single academic center between March 2006 and April 2018...
July 22, 2021: Cancer
https://read.qxmd.com/read/34292584/volume-standards-and-outcomes-measurement-complementary-strategies-to-improve-surgical-quality
#17
EDITORIAL
Sidra N Bonner, Justin B Dimick
No abstract text is available yet for this article.
July 22, 2021: Cancer
https://read.qxmd.com/read/34292583/the-impact-of-coronavirus-disease-2019-on-the-quality-of-life-and-treatment-disruption-of-patients-with-breast-cancer-in-a-multiethnic-cohort
#18
Fangyuan Zhao, Tara O Henderson, Toni M Cipriano, Brenda L Copley, Michelle Liu, Rahul Burra, Sondra H Birch, Olufunmilayo I Olopade, Dezheng Huo
BACKGROUND: As the coronavirus disease 2019 (COVID-19) pandemic continues to spread, it remains unclear how vulnerable populations with preexisting health conditions like cancer have been affected. METHODS: Between July and September of 2020, the authors conducted a cross-sectional study that surveyed 2661 patients with breast cancer who were registered in the Chicago Multiethnic Epidemiologic Breast Cancer Cohort and received 1300 responses (71.5% White patients and 22...
July 22, 2021: Cancer
https://read.qxmd.com/read/34292582/variation-in-outcomes-across-surgeons-meeting-the-leapfrog-volume-standard-for-complex-oncologic-surgery
#19
Christopher T Aquina, Adan Z Becerra, Fergal J Fleming, Jordan M Cloyd, Allan Tsung, Timothy M Pawlik, Aslam Ejaz
BACKGROUND: A large body of evidence supports regionalization of complex oncologic surgery to high-volume surgeons at high-volume hospitals. However, whether there is heterogeneity of outcomes among high-volume surgeons at high-volume hospitals remains unknown. METHODS: Patients who underwent esophagectomy, lung resection, pancreatectomy, or proctectomy for primary cancer were identified within the Medicare 100% Standard Analytic File (2013-2017). Mixed-effects analyses assessed the association between Leapfrog annual volume standards for surgeons (esophagectomy ≥7, lung resection ≥15, pancreatectomy ≥10, proctectomy ≥6) and hospitals (esophagectomy ≥20, lung resection ≥40, pancreatectomy ≥20, proctectomy ≥16) relative to postoperative complications and 90-day mortality...
July 22, 2021: Cancer
https://read.qxmd.com/read/34292579/erratum-to-toxicity-associated-with-intensive-postinduction-therapy-incorporating-clofarabine-in-the-very-high-risk-stratum-of-patients-with-newly-diagnosed-high-risk-b-lymphoblastic-leukemia-a-report-from-the-children-s-oncology-group-study-aall1131
#20
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