Iman Abou Dalle, Hagop M Kantarjian, Farhad Ravandi, Naval Daver, Xuemei Wang, Elias Jabbour, Zeev Estrov, Courtney D DiNardo, Naveen Pemmaraju, Alessandra Ferrajoli, Nitin Jain, Sa A Wang, Nadya Jammal, Gautam Borthakur, Kiran Naqvi, Sarah Pelletier, Sherry Pierce, Michael Andreeff, Guillermo Garcia-Manero, Jorge E Cortes, Tapan M Kadia
BACKGROUND: New drug combinations have led to significant improvements in remission rates for patients with acute myeloid leukemia (AML). However, many patients with high-risk AML who respond to their initial treatment and are not candidates for allogeneic stem cell transplantation (ASCT) will eventually relapse with poor outcomes. METHODS: In this phase 2 trial, the efficacy of lenalidomide maintenance was evaluated in patients with high-risk AML who had achieved their first or second remission after induction chemotherapy and at least 1 consolidation cycle and who were not candidates for immediate ASCT...
January 15, 2021: Cancer
Hebah Alhumaidi, Rami Manochakian, Jordan Cochuyt, Ana Chindris, David Hodge, Mays F Abdulazeez, Shishir David, Suman Biswas, Chander Shekher Aggarwal, Robert C Smallridge, Sikander Ailawadhi
BACKGROUND: Factors associated with receiving initial care for thyroid cancer (TC) at academic centers (ACs) versus nonacademic centers (NACs) and their impact on patient outcomes have not been reported. METHODS: The National Cancer Database with TC cases from 2004 to 2013 was evaluated for association of type of center for initial care with socioeconomic factors and disease and treatment characteristics, as well as overall survival (OS; all-cause mortality). RESULTS: The patients with TC (n = 200,824) included were predominantly women (74%), non-Hispanic Whites (85%), and from metro areas (84%)...
January 15, 2021: Cancer
Keunchil Park, Pasi A Jӓnne, Dong-Wan Kim, Ji-Youn Han, Ming-Fang Wu, Jong-Seok Lee, Jin-Hyoung Kang, Dae Ho Lee, Byoung Chul Cho, Chong-Jen Yu, Yong Kek Pang, Enriqueta Felip, Hyunjin Kim, Eunhye Baek, Young Su Noh
BACKGROUND: In this open-label, international phase 2 study, the authors assessed the efficacy and safety of olmutinib in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who had a confirmed T790M mutation and disease progression on previous epidermal growth factor receptor-tyrosine kinase inhibitor therapy. METHODS: Patients aged ≥20 years received once-daily oral olmutinib 800 mg continuously in 21-day cycles. The primary endpoint was the objective response rate (patients who had a confirmed best overall response of a complete or partial response), assessed by central review...
January 12, 2021: Cancer
Virginia E Drake, Carole Fakhry, Melina J Windon, C Matthew Stewart, Lee Akst, Alexander Hillel, Wade Chien, Patrick Ha, Brett Miles, Christine G Gourin, Rajarsi Mandal, Wojciech K Mydlarz, Lisa Rooper, Tanya Troy, Siddhartha Yavvari, Tim Waterboer, Nicole Brenner, David W Eisele, Gypsyamber D'Souza
BACKGROUND: Case-control studies from the early 2000s demonstrated that human papillomavirus-related oropharyngeal cancer (HPV-OPC) is a distinct entity associated with number of oral sex partners. Using contemporary data, we investigated novel risk factors (sexual debut behaviors, exposure intensity, and relationship dynamics) and serological markers on odds of HPV-OPC. METHODS: HPV-OPC patients and frequency-matched controls were enrolled in a multicenter study from 2013 to 2018...
January 11, 2021: Cancer
Justin R Gregg, Xiaotao Zhang, Brian F Chapin, John F Ward, Jeri Kim, John W Davis, Carrie R Daniel
BACKGROUND: The Mediterranean diet (MD) may be beneficial for men with localized prostate cancer (PCa) on active surveillance (AS) because of its anti-inflammatory, antilipidemic, and chemopreventive properties. This study prospectively investigated adherence to the MD with Gleason score progression and explored associations by diabetes status, statin use, and other factors. METHODS: Men with newly diagnosed PCa on an AS protocol (n = 410) completed a baseline food frequency questionnaire, and the MD score was calculated across 9 energy-adjusted food groups...
January 7, 2021: Cancer
Christina Schindera, Simeon Joel Zürcher, Ruedi Jung, Sarah Boehringer, Jan Willem Balder, Corina Silvia Rueegg, Susi Kriemler, Nicolas Xavier von der Weid
BACKGROUND: Childhood cancer survivors are at risk for cardiovascular disease (CVD) because of intensive cancer therapies often accompanied by an unhealthy lifestyle. This study was aimed at 1) describing modifiable CVD risk factors in survivors and 2) investigating the association between different aspects of physical fitness and CVD risk factors. METHODS: The authors analyzed cross-sectional data from ≥5-year survivors who were 16 years old or younger at their cancer diagnosis and 16 years old or older at the time of the study...
January 6, 2021: Cancer
Yu-Tsai Lin, Hung-Chen Wang, Ming-Hsien Tsai, Yan-Ye Su, Ming-Yu Yang, Chih-Yen Chien
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a common type of head and neck cancer in Asia. Adverse effects occur in over 90% of NPC patients treated with radiotherapy or chemoradiation. Angiotensin II receptor blockers (ARBs) are commonly used to treat hypertension without serious adverse effects. However, the anticancer activity of ARBs in NPC remains unclear. METHODS: We investigated the survival impacts of ARBs among NPC patients in a retrospective study. The anticancer effects and related signaling pathways of the ARBs valsartan and losartan were also evaluated in vitro and in vivo...
January 6, 2021: Cancer
María Elena Martínez, Jesse N Nodora, Luis G Carvajal-Carmona
No abstract text is available yet for this article.
January 6, 2021: Cancer
Paul Riviere, Lucas K Vitzthum, Vinit Nalawade, Rishi Deka, Timothy Furnish, Loren K Mell, Brent S Rose, Mark Wallace, James D Murphy
BACKGROUND: Clinical guidelines recommend that providers risk-stratify patients with cancer before prescribing opioids. Prior research has demonstrated that a simple cancer opioid risk score might help identify to patients with cancer at the time of diagnosis with a high likelihood of long-term posttreatment opioid use. This current project validates this cancer opioid risk score in a generalizable, population-based cohort of elderly cancer survivors. METHODS: This study identified 44,932 Medicare beneficiaries with cancer who had received local therapy...
December 30, 2020: Cancer
Aakash Desai, Rohit Gupta, Shailesh Advani, Lara Ouellette, Nicole M Kuderer, Gary H Lyman, Ang Li
BACKGROUND: Heterogeneous evidence exists on the effect of coronavirus disease 2019 (COVID-19) on the clinical outcomes of patients with cancer. METHODS: A systematic review was performed using the Medline, Embase, and CENTRAL databases and the World Health Organization Novel Coronavirus website to identify studies that reported mortality and characteristics of patients with cancer who were diagnosed with COVID-19. The primary study outcome was mortality, defined as all-cause mortality or in-hospital mortality within 30 days of initial COVID-19 diagnosis...
December 30, 2020: Cancer
Aasha I Hoogland, Heather S L Jim, Brian D Gonzalez, Brent J Small, Danielle Gilvary, Elizabeth C Breen, Julienne E Bower, Mayer Fishman, Babu Zachariah, Paul B Jacobsen
BACKGROUND: Increases in fatigue, depressive symptomatology, and cognitive impairment are common after the initiation of androgen deprivation therapy (ADT) for prostate cancer. To date, no studies have examined the potential role of inflammation in the development of these symptoms in ADT recipients. The goal of the current study was to examine circulating markers of inflammation as potential mediators of change in fatigue, depressive symptomatology, and cognitive impairment related to the receipt of ADT...
December 30, 2020: Cancer
Bassel Nazha, Mehmet Asim Bilen
No abstract text is available yet for this article.
December 30, 2020: Cancer
Gregory C Knapp, Gavin Tansley, Olalekan Olasehinde, Funmilola Wuraola, Adewale Adisa, Olukayode Arowolo, M O Olawole, Anya M Romanoff, May Lynn Quan, Antoine Bouchard-Fortier, Olusegun I Alatise, T Peter Kingham
BACKGROUND: The majority of women in Nigeria present with advanced-stage breast cancer. To address the role of geospatial access, we constructed a geographic information-system-based model to evaluate the relationship between modeled travel time, stage at presentation, and overall survival among patients with breast cancer in Nigeria. METHODS: Consecutive patients were identified from a single-institution, prospective breast cancer database (May 2009-January 2019)...
December 28, 2020: Cancer
Jeana E Havidich, Julie E Weiss, Tracy L Onega, Ying H Low, Martha E Goodrich, Mathew A Davis, Brian D Sites
BACKGROUND: Cancer is the second leading cause of death globally, and researchers seek to identify modifiable risk factors Over the past several decades, there has been ongoing debate whether opioids are associated with cancer development, metastasis, or recurrence. Basic science, clinical, and observational studies have produced conflicting results. The authors examined the association between prescription opioids and incident cancers using the Surveillance, Epidemiology, and End Results (SEER)-Medicare database...
December 28, 2020: Cancer
Ingrid Tonning Olsson, Nicole M Alberts, Chenghong Li, Matthew J Ehrhardt, Daniel A Mulrooney, Wei Liu, Alberto S Pappo, Michael W Bishop, Doralina L Anghelescu, Deokumar Srivastava, Leslie L Robison, Melissa M Hudson, Kirsten K Ness, Kevin R Krull, Tara M Brinkman
BACKGROUND: Although survivors of childhood cancer are at risk of chronic pain, the impact of pain on daily functioning is not well understood. METHODS: A total of 2836 survivors (mean age, 32.2 years [SD, 8.5 years]; mean time since diagnosis, 23.7 years [SD, 8.2 years]) and 343 noncancer community controls (mean age, 35.5 years [SD, 10.2 years]) underwent comprehensive medical, neurocognitive, and physical performance assessments, and completed measures of pain, health-related quality of life (HRQOL), and social functioning...
December 28, 2020: Cancer
Grant R Williams, Mustafa Al-Obaidi, Chen Dai, Smita Bhatia, Smith Giri
BACKGROUND: Sarcopenia is associated with adverse outcomes among older adults with cancer; however, no easily applied sarcopenia measure exists for use in clinical practice. The use of SARC-F, a 5-item self-reported sarcopenia screening questionnaire, among older adults with cancer remains to be investigated. METHODS: Older adults (aged ≥60 years) with cancer enrolled in the University of Alabama Cancer and Aging Resilience Evaluation Registry were identified...
December 28, 2020: Cancer
Christopher R D'Angelo, Sailendharan Sudakaran, Natalie S Callander
The gut microbiome and its effects on host immunity have exciting implications for cancer prognosis and therapy. Examples in allogeneic hematopoietic stem cell transplantation (allo-SCT) demonstrate the role of the gut microbiome as a biomarker for clinical outcomes, and animal models demonstrate how microbiota manipulation may augment therapeutic responses. There are multiple mechanisms that gut microbiota may have in affecting distant tumor environments, including control of cytokine release, dendritic cell activation, and T-cell lymphocyte stimulation...
December 28, 2020: Cancer
Echo L Warner, Austin R Waters, Kristin G Cloyes, Lee Ellington, Anne C Kirchhoff
BACKGROUND: The objective of this study was to describe young adult cancer caregivers' exposure to cancer misinformation on social media. METHODS: Eligible participants were 18 to 39 years old, used social media weekly, and cared for an adult patient with cancer diagnosed 6 months to 5 years before (N = 21). Recruitment occurred from August 2017 to June 2018 in person at oncology clinics and online. Semistructured telephone interviews were recorded and analyzed with grounded theory methods through 2 rounds of coding (κ = 0...
December 23, 2020: Cancer
Michelle A Mollica, Wen-Ying Sylvia Chou, Emily S Tonorezos, Ashley Wilder Smith
No abstract text is available yet for this article.
December 23, 2020: Cancer
Lorine Haeuser, Maya Marchese, Deborah Schrag, Quoc-Dien Trinh, Steven L Chang, Adam S Kibel, John L Gore, Joachim Noldus, Matthew Mossanen
BACKGROUND: Smoking, the most common risk factor for bladder cancer (BC), is associated with increased complications after radical cystectomy (RC), poorer oncologic outcomes, and higher mortality. The authors hypothesized that the effect of smoking on the probability of major complications increases with increasing age among patients who undergo RC. METHODS: The authors analyzed the American College of Surgeons National Surgical Quality Improvement Program database (2011-2017), identified all patients undergoing RC using Current Procedural Terminology codes, and formed two groups according to smoking status (active smoker and nonsmoker [included former and never-smokers])...
December 22, 2020: Cancer
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