Jung Julie Kang, Yao Yu, Linda Chen, Kaveh Zakeri, Daphna Yael Gelblum, Sean Matthew McBride, Nadeem Riaz, C Jillian Tsai, Anuja Kriplani, Tony K W Hung, James V Fetten, Lara A Dunn, Alan L Ho, Jay O Boyle, Ian S Ganly, Bhuvanesh Singh, Eric J Sherman, David G Pfister, Richard J Wong, Nancy Y Lee
The most common cancer caused by human papillomavirus (HPV) infection in the United States is oropharyngeal cancer (OPC), and its incidence has been rising since the turn of the century. Because of substantial long-term morbidities with chemoradiation and the favorable prognosis of HPV-positive OPC, identifying the optimal deintensification strategy for this group has been a keystone of academic head-and-neck surgery, radiation oncology, and medical oncology for over the past decade. However, the first generation of randomized chemotherapy deintensification trials failed to change the standard of care, triggering concern over the feasibility of de-escalation...
March 2023: CA: a Cancer Journal for Clinicians