journal
https://read.qxmd.com/read/37989536/genomics-enabling-personalised-glaucoma-care
#61
REVIEW
Kelsey V Stuart, Anthony P Khawaja
Glaucoma is a leading cause of visual impairment and a significant public health concern, but despite ongoing advances in our understanding of the disease, several important clinical challenges remain. With the number of affected people projected to increase substantially over coming decades, novel approaches to screening, risk stratification, therapy and glaucoma research are essential to deal with this expanding burden in an efficient and cost-effective manner. Genomics may hold the key to unlocking further biological insights and enabling precision medicine, in which glaucoma care is tailored to the individual patient, based on their unique profile for disease...
December 18, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37890881/more-support-for-deep-anterior-lamellar-keratoplasty-over-penetrating-keratoplasty-for-keratoconus-but-questions-remain
#62
EDITORIAL
Uri S Soiberman, Albert S Jun
No abstract text is available yet for this article.
December 18, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37890880/long-term-outcomes-of-deep-anterior-lamellar-versus-penetrating-keratoplasty-for-keratoconus
#63
JOURNAL ARTICLE
Vincent Michel Borderie, Cristina Georgeon, Otman Sandali, N Bouheraoua
AIMS: To compare the long-term outcomes of deep anterior lamellar keratoplasty (DALK) with penetrating keratoplasty (PK) in keratoconus. METHODS: Retrospective comparative case series (228 DALKs and 274 PKs). A biphasic linear model was used to describe the postoperative outcome of the endothelial cell density (ECD). Visual acuity, specular microscopy, corneal topography and optical coherence tomography findings were recorded. RESULTS: Graft survival of the 502 keratoconus eyes was 96...
December 18, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/36717199/ophthalmological-outcome-of-6-5-years-children-treated-for-retinopathy-of-prematurity-a-swedish-register-study
#64
JOURNAL ARTICLE
Eva Larsson, Ann Hellström, Kristina Tornqvist, Agneta Wallin, Birgitta Sunnqvist, Karin Sandgren Hochhard, Pia Lundgren, Abbas Al-Hawasi, Kristina Teär Fahnehjelm, Lotta Gränse, Gerd Holmstrom
AIMS: To determine the ophthalmological outcome at 6.5 years of age in children treated for retinopathy of prematurity (ROP), and registered in the national Swedish National Register for ROP register. METHODS: Data on ROP, treatment and ophthalmological outcome were retrieved from the register. Visual acuity (VA), refractive errors and strabismus, together with visual impairment (VI) and any significant eye problem, defined as VA >0.5 logarithm of the minimal angle of resolution (logMAR) and/or strabismus and/or any refractive error were analysed...
December 18, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/36428008/arterial-hypertension-and-retinal-layer-thickness-the-beijing-eye-study
#65
JOURNAL ARTICLE
Hui Xie, Zhe Pan, Can Can Xue, Danny Chen, Jost B Jonas, Xiaodong Wu, Ya Xing Wang
PURPOSE: To investigate relationships between blood pressure and the thickness of single retinal layers in the macula. METHODS: Participants of the population-based Beijing Eye Study, free of retinal or optic nerve disease, underwent medical and ophthalmological examinations including optical coherence tomographic examination of the macula. Applying a multiple-surface segmentation solution, we automatically segmented the retina into its various layers. RESULTS: The study included 2237 participants (mean age 61...
December 18, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/36418145/identifying-central-10%C3%A2-visual-subfield-associated-with-future-worsening-of-visual-acuity-in-eyes-with-advanced-glaucoma
#66
JOURNAL ARTICLE
Ryo Asaoka, Kenji Sugisaki, Toshihiro Inoue, Keiji Yoshikawa, Akiyasu Kanamori, Yoshio Yamazaki, Shinichiro Ishikawa, Kenichi Uchida, Aiko Iwase, Makoto Araie
BACKGROUND/AIMS: To determine a cluster of test points: visual subfield (VSF) of Humphrey Field Analyzer 10-2 test (HFA 10-2) of which baseline sensitivities were associated with future worsening of visual acuity (VA) in eyes with advanced glaucoma. METHODS: A total of 175 advanced glaucoma eyes of 175 advanced glaucoma patients with well controlled intraocular pressure (IOP), a mean deviation of the Humphrey Field Analyzer 24-2 (HFA 24-2) test ≤ -20 decibels and best corrected VA ≥20/40, were included...
December 18, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38164546/endophthalmitis-rates-and-risk-factors-following-intraocular-surgeries-can-we-turn-big-data-benchmarks-into-patient-benefit
#67
JOURNAL ARTICLE
John Buchan
No abstract text is available yet for this article.
December 13, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38164543/predicting-the-risk-of-glaucoma-related-adverse-events-following-secondary-intraocular-lens-implantation-in-paediatric-eyes-a-3-year-study
#68
JOURNAL ARTICLE
Hui Chen, Chaoqun Xu, Ling Jin, Zhenyu Wang, Jingmin Xu, Yingshi Zou, Guangming Jin, Lixia Luo, Haotian Lin, Weirong Chen, Danying Zheng, Yizhi Liu, Zhenzhen Liu
AIMS: To establish and evaluate predictive models for glaucoma-related adverse events (GRAEs) following secondary intraocular lens (IOL) implantation in paediatric eyes. METHODS: 205 children (356 aphakic eyes) receiving secondary IOL implantation at Zhongshan Ophthalmic Center with a 3-year follow-up were enrolled. Cox proportional hazard model was used to identify predictors of GRAEs and developed nomograms. Model performance was evaluated with time-dependent receiver operating characteristic (ROC) curves, decision curve analysis, Kaplan-Meier curves and validated internally through C-statistics and calibration plot of the bootstrap samples...
December 13, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38164527/light-exposure-therapy-for-myopia-control-a-systematic-review-and-bayesian-network-meta-analysis
#69
JOURNAL ARTICLE
Ebenezer Zaabaar, Xiu Juan Zhang, Yuzhou Zhang, Christine H T Bui, Fang Yao Tang, Ka Wai Kam, Simon K H Szeto, Alvin L Young, Ian C K Wong, Patrick Ip, Clement C Tham, Chi Pui Pang, Li Jia Chen, Jason C Yam
AIMS: To compare and rank the myopia control effects of different light wavelengths in children using a systematic review and Bayesian network meta-analysis (Bayesian NMA). METHODS: The review protocol was registered with PROSPERO. We searched PubMed, EMBASE and MEDLINE for relevant clinical and animal studies published as of 2 February 2023. We included studies comparing red, violet or full-spectrum light with controls. Data extracted included descriptive statistics and study outcomes (axial length (AL) elongation and progression of spherical equivalent (SE) refraction)...
December 13, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38164563/review-of-emerging-trends-and-projection-of-future-developments-in-large-language-models-research-in-ophthalmology
#70
JOURNAL ARTICLE
Matthew Wong, Zhi Wei Lim, Krithi Pushpanathan, Carol Y Cheung, Ya Xing Wang, David Chen, Yih Chung Tham
BACKGROUND: Large language models (LLMs) are fast emerging as potent tools in healthcare, including ophthalmology. This systematic review offers a twofold contribution: it summarises current trends in ophthalmology-related LLM research and projects future directions for this burgeoning field. METHODS: We systematically searched across various databases (PubMed, Europe PMC, Scopus and Web of Science) for articles related to LLM use in ophthalmology, published between 1 January 2022 and 31 July 2023...
December 11, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38164583/measurement-of-visual-function-in-infantile-nystagmus-a-systematic-review
#71
JOURNAL ARTICLE
Bader Almagren, Matt J Dunn
BACKGROUND/AIMS: Recent work has called into question the ability of visual acuity (VA) to accurately represent changes in visual function in infantile nystagmus (IN). This systematic review investigated factors affecting visual performance in IN, to guide development of suitable alternatives to VA. METHODS: Included studies used an experimental manipulation to assess changes in visual function in people with IN. Interventional studies, case series and case studies were excluded...
December 6, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38164569/detailed-measurements-of-the-four-extraocular-rectus-muscles-contribution-to-the-perfusion-of-the-anterior-segment-of-the-eye
#72
JOURNAL ARTICLE
Linn Engqvist, Rafi Sheikh, HannaMaria Öhnell, Ulf Dahlstrand
BACKGROUND/AIMS: Anterior segment ischaemia (ASI) is a rare but serious complication of strabismus surgery, which may be caused by damage to the anterior ciliary arteries that run along the rectus muscles. To avoid ASI, clinical praxis is to operate on a maximum of two rectus muscles at a time. The aim of this study was to perform a detailed study of the contribution of the four ocular rectus muscles to the perfusion of the anterior segment using laser speckle contrast imaging (LSCI)...
December 6, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38164558/long-term-effect-of-orthokeratology-on-choroidal-thickness-and-choroidal-contour-in-myopic-children
#73
JOURNAL ARTICLE
Shengsong Xu, Mengyi Wang, Sijia Lin, Jinyun Jiang, Mengting Yu, Xianghua Tang, Danxi Xie, Mingxin Lu, Zhouyue Li, Xiao Yang
PURPOSE: To investigate the long-term effect of orthokeratology (ortho-k) on the choroidal thickness and choroidal contour in myopic children. METHODS: Subjects were from a conducted 2-year randomised clinical trial. Children (n=80) aged 8-12 years with spherical equivalent refraction of -1.00 to -6.00D were randomly assigned to the control group (n=40) and ortho-k group (n=40). Optical coherence tomography images were collected at the baseline, 1-month, 6-month, 12-month, 18-month and 24-month visits, then the choroidal thickness and choroid contour were calculated...
December 6, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38164556/long-term-variability-of-retinal-nerve-fibre-layer-thickness-measurement-in-patients-with-glaucoma-of-african-and-european-descents
#74
JOURNAL ARTICLE
Jo-Hsuan Wu, Sasan Moghimi, Evan Walker, Takashi Nishida, Jeffrey M Liebmann, Massimo A Fazio, Christopher A Girkin, Linda M Zangwill, Robert N Weinreb
BACKGROUND: To examine long-term retinal nerve fibre layer thickness (RNFLT) variability and associated clinical factors in African (AD) and European descent (ED) individuals with glaucoma. METHODS: This retrospective cohort study included glaucoma eyes of AD and ED from Diagnostic Innovations in Glaucoma Study/The African Descent and Glaucoma Evaluation Study with ≥4 visits/2 years of follow-up. We calculated optic nerve head RNFLT variability per-examination/visit as the absolute error of its residuals across follow-up...
December 6, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38164537/intraocular-pressure-reduction-and-progression-of-highly-myopic-glaucoma-a-12-year-follow-up-cohort-study
#75
JOURNAL ARTICLE
Young In Shin, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
AIMS: To investigate any association between intraocular pressure (IOP) reduction amount and open-angle glaucoma (OAG) progression in highly myopic eyes and to determine the associated risk factors. METHODS: One hundred and thirty-one (131) eyes of 131 patients with highly myopic OAG, all of whom had received topical medications and been followed for 5 years or longer, were enrolled. Based on the IOP reduction percentage, patients were categorised into tertile groups, and subsequently, the upper-tertile and lower-tertile groups were compared for the cumulative probability of glaucoma progression...
December 6, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38041683/retinal-detachment-risk-in-the-fellow-eyes-of-patients-presenting-with-retinal-tears-in-more-than-two-quadrants
#76
JOURNAL ARTICLE
Xiaoman Li, Arabella V Poulson, Martin P Snead
Literature discussing fellow eye risk in patients with rhegmatogenous retinal detachment secondary to posterior vitreous detachment (PVD) is limited, particularly in subgroups where this risk may be greater than the general population. In this retrospective consecutive case series with 107 study patients, the risk of retinal tears in fellow eyes of patients with horseshoe tears in three or more quadrants of their presenting eye, secondary to PVD, was 81%. The fellow eye risk is high in this subgroup of patients, and it is important to inform them to seek prompt attention when symptoms of PVD develop in their fellow eye...
November 28, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38041678/early-use-of-intravitreal-triamcinolone-to-inhibit-traumatic-proliferative-vitreoretinopathy-a-randomised-clinical-trial
#77
JOURNAL ARTICLE
Haixia Guo, Jinguo Yu, Tiangeng He, Song Chen, Zhuoyu Sun, Jingkai Zhang, Zhiyong Sun, Wenhui Yang, Baoqun Yao, Xueli Yang, Yuanyuan Liu, Mingxue Zhang, Yu Meng, Likun Yang, Hua Yan
AIMS: To evaluate the efficacy and safety of intravitreal triamcinolone acetonide (TA) injection at the end of emergency surgery for open globe injury (OGI) to suppress traumatic proliferative vitreoretinopathy (TPVR). METHODS: A single-centre, participant-masked, prospective, randomised controlled clinical trial. A total of 68 globe rupture patients with zone III were randomised to the control group (n=34) or the TA group (n=34) in 1:1 allocation ratio. Patients were treated with 0...
November 28, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38041682/effects-of-orbital-decompression-on-duction-cyclotorsion-and-diplopia
#78
JOURNAL ARTICLE
Hinke Marijke Jellema, Martina Althaus, Elly Merckel-Timmer, Dyonne T Hartong, Roel Kloos, Peerooz Saeed
BACKGROUND: Orbital decompression is commonly performed to correct proptosis in patients with Graves' orbitopathy (GO). In literature, the incidence of new-onset constant diplopia after orbital decompression varies. Few studies have evaluated changes in duction and cyclodeviation after orbital decompression. We evaluated the changes in duction, cyclodeviation, eye position and degree of diplopia after orbital decompression. METHODS: We retrospectively analysed data from patients who underwent orbital decompression at our hospital between January 2016 and July 2020...
November 27, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38041675/age-matched-analysis-of-axial-length-growth-in-myopic-children-wearing-defocus-incorporated-multiple-segments-spectacle-lenses
#79
JOURNAL ARTICLE
Birte Graff, Carly S Y Lam, Natalia Vlasak, Hakan Kaymak
BACKGROUND/AIMS: Defocus incorporated multiple segments (DIMS) spectacle lenses are known to be able to inhibit axial length (AL) growth in myopic children compared with single vision (SV) spectacle lenses. However, it is not known whether AL growth is sufficiently inhibited to achieve the treatment goal of physiological AL growth. METHODS: Of the data already collected in 2014-2017 by Lam et al , the AL growth with DIMS and SV spectacle lenses was re-evaluated according to the age-matched myopia control system...
November 27, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/38041661/ocular-inflammatory-events-following-covid-19-vaccination-reporting-of-suspected-adverse-drug-reactions-to-regulatory-authorities-in-the-uk
#80
JOURNAL ARTICLE
Ilaria Testi, Taha Soomro, Carlos Pavesio, Ameenat Lola Solebo
BACKGROUND/AIMS: The UK Medicines and Healthcare products Regulatory Agency (MHRA) has published suspected adverse drug reactions to vaccines against COVID-19. Ocular inflammatory events following COVID-19 vaccination have been reported worldwide. METHODS: We analysed MHRA data on spontaneous reports of suspected ocular inflammatory events following COVID-19 vaccination between January 2021 and September 2022. RESULTS: The MHRA received 300 UK spontaneous suspected reports of ocular inflammatory events following COVID-19 vaccination, with a calculated prevalence of 6...
November 27, 2023: British Journal of Ophthalmology
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