journal
https://read.qxmd.com/read/37890880/long-term-outcomes-of-deep-anterior-lamellar-versus-penetrating-keratoplasty-for-keratoconus
#41
JOURNAL ARTICLE
Vincent Michel Borderie, Cristina Georgeon, Otman Sandali, N Bouheraoua
AIMS: To compare the long-term outcomes of deep anterior lamellar keratoplasty (DALK) with penetrating keratoplasty (PK) in keratoconus. METHODS: Retrospective comparative case series (228 DALKs and 274 PKs). A biphasic linear model was used to describe the postoperative outcome of the endothelial cell density (ECD). Visual acuity, specular microscopy, corneal topography and optical coherence tomography findings were recorded. RESULTS: Graft survival of the 502 keratoconus eyes was 96...
December 18, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/36717199/ophthalmological-outcome-of-6-5-years-children-treated-for-retinopathy-of-prematurity-a-swedish-register-study
#42
JOURNAL ARTICLE
Eva Larsson, Ann Hellström, Kristina Tornqvist, Agneta Wallin, Birgitta Sunnqvist, Karin Sandgren Hochhard, Pia Lundgren, Abbas Al-Hawasi, Kristina Teär Fahnehjelm, Lotta Gränse, Gerd Holmstrom
AIMS: To determine the ophthalmological outcome at 6.5 years of age in children treated for retinopathy of prematurity (ROP), and registered in the national Swedish National Register for ROP register. METHODS: Data on ROP, treatment and ophthalmological outcome were retrieved from the register. Visual acuity (VA), refractive errors and strabismus, together with visual impairment (VI) and any significant eye problem, defined as VA >0.5 logarithm of the minimal angle of resolution (logMAR) and/or strabismus and/or any refractive error were analysed...
December 18, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/36428008/arterial-hypertension-and-retinal-layer-thickness-the-beijing-eye-study
#43
JOURNAL ARTICLE
Hui Xie, Zhe Pan, Can Can Xue, Danny Chen, Jost B Jonas, Xiaodong Wu, Ya Xing Wang
PURPOSE: To investigate relationships between blood pressure and the thickness of single retinal layers in the macula. METHODS: Participants of the population-based Beijing Eye Study, free of retinal or optic nerve disease, underwent medical and ophthalmological examinations including optical coherence tomographic examination of the macula. Applying a multiple-surface segmentation solution, we automatically segmented the retina into its various layers. RESULTS: The study included 2237 participants (mean age 61...
December 18, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37875375/diabetic-retinopathy-screening-does-one-size-fit-all
#44
JOURNAL ARTICLE
Parul Desai, Samantha R De Silva
No abstract text is available yet for this article.
November 22, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37875374/two-year-recall-for-people-with-no-diabetic-retinopathy-a-multi-ethnic-population-based-retrospective-cohort-study-using-real-world-data-to-quantify-the-effect
#45
JOURNAL ARTICLE
Abraham Olvera-Barrios, Alicja R Rudnicka, John Anderson, Louis Bolter, Ryan Chambers, Alasdair N Warwick, Roshan Welikala, Jiri Fajtl, Sarah Barman, Paolo Remgnino, Yue Wu, Aaron Y Lee, Emily Y Chew, Frederick L Ferris, Aroon Hingorani, Reecha Sofat, Catherine A Egan, Adnan Tufail, Christopher G Owen
BACKGROUND/AIMS: The English Diabetic Eye Screening Programme (DESP) offers people living with diabetes (PLD) annual screening. Less frequent screening has been advocated among PLD without diabetic retinopathy (DR), but evidence for each ethnic group is limited. We examined the potential effect of biennial versus annual screening on the detection of sight-threatening diabetic retinopathy (STDR) and proliferative diabetic retinopathy (PDR) among PLD without DR from a large urban multi-ethnic English DESP...
November 22, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37739769/comparison-of-mini-simple-limbal-epithelial-transplantation-and-conjunctival-limbal-autograft-for-the-treatment-of-primary-pterygium-a-randomised-controlled-trial
#46
RANDOMIZED CONTROLLED TRIAL
Valeria Oliva-Biénzobas, Angel Nava-Castañeda, Aida Jimenez-Corona, Nicolás Kahuam-López, Arturo Ramirez-Miranda, Alejandro Navas, Enrique O Graue-Hernandez
PURPOSE: The purpose of this double-masked, parallel randomised controlled trial was to compare the recurrence rate and other outcomes between conjunctival-limbal autograft (CLAu) and mini-simple limbal epithelial transplantation (mini-SLET) after excision of pterygium. METHODS: Eligibility criteria for participants was the presence of a primary nasal pterygium extending equally to or greater than two millimetres on the cornea on its horizontal axis from the nasal limbus...
November 22, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/36344262/association-of-lipid-lowering-drugs-and-antidiabetic-drugs-with-age-related-macular-degeneration-a-meta-analysis-in-europeans
#47
JOURNAL ARTICLE
Matthias M Mauschitz, Timo Verzijden, Alexander K Schuster, Hisham Elbaz, Norbert Pfeiffer, Anthony Khawaja, Robert N Luben, Paul J Foster, Franziska G Rauscher, Kerstin Wirkner, Toralf Kirsten, Jost B Jonas, Mukharram M Bikbov, Ruth Hogg, Tunde Peto, Audrey Cougnard-Grégoire, Geir Bertelsen, Maja Gran Erke, Fotis Topouzis, Dimitrios A Giannoulis, Caroline Brandl, Iris M Heid, Catherine P Creuzot-Garcher, Pierre-Henry Gabrielle, Hans-Werner Hense, Daniel Pauleikhoff, Patricia Barreto, Rita Coimbra, Stefano Piermarocchi, Vincent Daien, Frank G Holz, Cecile Delcourt, Robert P Finger
BACKGROUND/AIMS: To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. METHODS: We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis...
November 22, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/36229177/effect-of-atropine-orthokeratology-and-combined-treatments-for-myopia-control-a-2-year-stratified-randomised-clinical-trial
#48
RANDOMIZED CONTROLLED TRIAL
Shengsong Xu, Zhouyue Li, Wenchen Zhao, Bingru Zheng, Jinyun Jiang, Guitong Ye, Zhibin Feng, Wen Long, Liying He, Mingguang He, Yin Hu, Xiao Yang
PURPOSE: To investigate the 2-year efficacy of atropine, orthokeratology (ortho-k) and combined treatment on myopia. To explore the factors influencing the efficacy. METHODS: An age-stratified randomised controlled trial. Children (n=164) aged 8-12 years with spherical equivalent refraction of -1.00 to -6.00 D were stratified into two age subgroups and randomly assigned to receive placebo drops+spectacles (control), 0.01% atropine+spectacles (atropine), ortho-k+placebo (ortho-k) or combined treatment...
November 22, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/36167484/effect-of-spectacle-lenses-with-aspherical-lenslets-on-choroidal-thickness-in-myopic-children-a-2-year-randomised-clinical-trial
#49
RANDOMIZED CONTROLLED TRIAL
Yingying Huang, Xue Li, Junqian Wu, Jiawen Huo, Fengchao Zhou, Jiali Zhang, Adeline Yang, Daniel P Spiegel, Hao Chen, Jinhua Bao
OBJECTIVE: Spectacle lenses with highly aspherical lenslets (HAL) and slightly aspherical lenslets (SAL) showed effective myopia control. This study was to investigate their effects on macular choroidal thickness (ChT) in myopic children. METHODS: Exploratory analysis from a 2-year, double-masked, randomised trial. 170 children aged 8-13 years with myopia between -0.75D and -4.75D, astigmatism of 1.50D or less, and anisometropia of 1.00D or less were recruited. Participants were randomly assigned in a 1:1:1 ratio to receive HAL, SAL or single vision spectacle lenses (SVL)...
November 22, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37963713/bietti-s-crystalline-dystrophy-genotyping-and-deep-qualitative-and-quantitative-phenotyping-in-preparation-for-clinical-trials
#50
JOURNAL ARTICLE
Qian Li, Cong Wang, Shengjuan Zhang, Zhongjie Fu, Xiaodong Jiao, Zi-Bing Jin, James Fielding Hejtmancik, Xiaoyan Peng
PURPOSE: To qualitatively and quantitatively characterise the genotypes and phenotypes of Bietti's crystalline dystrophy (BCD) in a cohort of patients. DESIGN: Cross-sectional and observational study. METHODS: Clinically confirmed BCD patients were recruited for genotyping and phenotyping. Multiple retinal imaging modalities were employed. Atrophy in the fovea was adopted as major consideration for staging strategy, while percentage area of autofluorescence (AF) atrophy (PAFA) in the macula was determined for quantitation...
November 14, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37963712/anterior-segment-involvement-in-vitreoretinal-lymphoma-clinical-manifestations-molecular-findings-and-in-vivo-confocal-microscopy
#51
JOURNAL ARTICLE
Alessandro Marchese, Carlo Di Biase, Maria Vittoria Cicinelli, Matteo Menean, Giulio Ferrari, Francesco Bandello, Giulio Modorati, Debra Anne Goldstein, Elisabetta Miserocchi
BACKGROUND: Intermediate and posterior manifestations of vitreoretinal lymphoma (VRL) are well characterised. However, there is limited information on anterior segment involvement in VRL. This study aimed to describe the anterior manifestations of VRL, and their association with molecular testing. METHODS: Retrospective analysis of patients with biopsy-proven VRL. Study variables included anterior segment manifestations, findings from slit-lamp photos and in vivo confocal microscopy (IVCM) when available...
November 14, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37940365/stargardt-macular-dystrophy-and-therapeutic-approaches
#52
REVIEW
Kaoru Fujinami, Nadia Waheed, Yannik Laich, Paul Yang, Yu Fujinami-Yokokawa, Joseph J Higgins, Jonathan T Lu, Darin Curtiss, Cathryn Clary, Michel Michaelides
Stargardt macular dystrophy (Stargardt disease; STGD1; OMIM 248200) is the most prevalent inherited macular dystrophy. STGD1 is an autosomal recessive disorder caused by multiple pathogenic sequence variants in the large ABCA4 gene (OMIM 601691). Major advances in understanding both the clinical and molecular features, as well as the underlying pathophysiology, have culminated in many completed, ongoing and planned human clinical trials of novel therapies.The aims of this concise review are to describe (1) the detailed phenotypic and genotypic characteristics of the disease, multimodal imaging findings, natural history of the disease, and pathogenesis, (2) the multiple avenues of research and therapeutic intervention, including pharmacological, cellular therapies and diverse types of genetic therapies that have either been investigated or are under investigation and (3) the exciting novel therapeutic approaches on the translational horizon that aim to treat STGD1 by replacing the entire 6...
November 8, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37932006/performance-of-chatgpt-and-bard-on-the-official-part-1-frcophth-practice-questions
#53
JOURNAL ARTICLE
Thomas Fowler, Simon Pullen, Liam Birkett
BACKGROUND: Chat Generative Pre-trained Transformer (ChatGPT), a large language model by OpenAI, and Bard, Google's artificial intelligence (AI) chatbot, have been evaluated in various contexts. This study aims to assess these models' proficiency in the part 1 Fellowship of the Royal College of Ophthalmologists (FRCOphth) Multiple Choice Question (MCQ) examination, highlighting their potential in medical education. METHODS: Both models were tested on a sample question bank for the part 1 FRCOphth MCQ exam...
November 6, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37923374/capabilities-of-gpt-4-in-ophthalmology-an-analysis-of-model-entropy-and-progress-towards-human-level-medical-question-answering
#54
JOURNAL ARTICLE
Fares Antaki, Daniel Milad, Mark A Chia, Charles-Édouard Giguère, Samir Touma, Jonathan El-Khoury, Pearse A Keane, Renaud Duval
BACKGROUND: Evidence on the performance of Generative Pre-trained Transformer 4 (GPT-4), a large language model (LLM), in the ophthalmology question-answering domain is needed. METHODS: We tested GPT-4 on two 260-question multiple choice question sets from the Basic and Clinical Science Course (BCSC) Self-Assessment Program and the OphthoQuestions question banks. We compared the accuracy of GPT-4 models with varying temperatures (creativity setting) and evaluated their responses in a subset of questions...
November 3, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37923373/european-glaucoma-society-research-priorities-for-glaucoma-care
#55
JOURNAL ARTICLE
Augusto Azuara-Blanco, Noleen McCorry, Andrew J Tatham, Stelios Georgoulas, Panayiota Founti, Cedric Schweitzer, Frances Meier-Gibbons, Philippe Denis, Anja Tuulonen, Gauti Johannesson, José María Martínez de la Casa, Verena Prokosch, Dimitrios A Giannoulis, Luis Abegão Pinto, David Garway-Heath, Fotis Topouzis
BACKGROUND/AIMS: The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that are important to patients and clinicians. The aim of this study was to develop a list of priorities for glaucoma research involving stakeholders from different countries in Europe. METHODS: We used a three-phase method, including a two-round electronic Delphi survey and a workshop. The clinician and patient electronic surveys were conducted in parallel and independently...
November 3, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37918892/strategic-combination-of-cultivated-oral-mucosal-epithelial-transplantation-and-postoperative-limbal-rigid-contact-lens-wear-for-end-stage-ocular-surface-disease-a-retrospective-cohort-study
#56
JOURNAL ARTICLE
Yulia Aziza, Kojiro Imai, Motohiro Itoi, Hokoru Yoshioka, Seitaro Komai, Koji Kitazawa, Ratna Sitompul, Mayumi Ueta, Hideki Fukuoka, Tsutomu Inatomi, Shigeru Kinoshita, Chie Sotozono
PURPOSE: To provide the long-term outcome of patients with end-stage severe ocular surface disease (OSD) consecutively treated with cultivated oral mucosal epithelial transplantation (COMET) followed by limbal-rigid contact lens (CL)-wear therapy. DESIGN: Retrospective cohort. METHODS: In 23 eyes of 18 patients with severe OSD who underwent COMET surgery between 2002 and 2019 and who were followed with limbal-rigid CL-wear therapy for at least 1 year postoperative, patient demographics, best-corrected visual acuity (BCVA, logMAR), Ocular Surface Grading Scores (OSGS), surgical indication and adverse events were reviewed...
November 2, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37918891/deep-learning-based-prediction-of-glaucoma-conversion-in-normotensive-glaucoma-suspects
#57
JOURNAL ARTICLE
Ahnul Ha, Sukkyu Sun, Young Kook Kim, Jin Wook Jeoung, Hee Chan Kim, Ki Ho Park
BACKGROUND/AIMS: To assess the performance of deep-learning (DL) models for prediction of conversion to normal-tension glaucoma (NTG) in normotensive glaucoma suspect (GS) patients. METHODS: Datasets of 12 458 GS eyes were reviewed. Two hundred and ten eyes (105 eyes showing NTG conversion and 105 without conversion), followed up for a minimum of 7 years during which intraocular pressure (IOP) was lower than 21 mm Hg, were included. The features of two fundus images (optic disc photography and red-free retinal nerve fibre layer (RNFL) photography) were extracted by convolutional auto encoder...
November 2, 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/37863500/association-of-baseline-optical-coherence-tomography-angiography-with-the-development-of-glaucomatous-visual-field-defects-in-preperimetric-glaucoma-eyes
#58
JOURNAL ARTICLE
Jin Yeong Lee, Joong Won Shin, Anna Lee, Min Su Baek, Michael S Kook
AIMS: To evaluate whether baseline vessel density (VD) parameters derived from optical coherence tomography angiography (OCT-A) is associated with the development of glaucomatous visual field (VF) defects in preperimetric glaucoma (PPG) patients. METHODS: One eye from each of 200 consecutive PPG patients with a normal standard automated perimetry and OCT-A at baseline was retrospectively analysed. OCT-A was used to measure the circumpapillary VD (cpVD) and the parafoveal and perifoveal VD...
November 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/36126105/control-of-myopia-using-diffusion-optics-spectacle-lenses-12-month-results-of-a-randomised-controlled-efficacy-and-safety-study-cypress
#59
RANDOMIZED CONTROLLED TRIAL
Joe Rappon, Carol Chung, Graeme Young, Christopher Hunt, Jay Neitz, Maureen Neitz, Thomas Chalberg
BACKGROUND: Mutations in the L/M cone opsin gene array cause abnormally high perceived retinal contrast and the development of myopia. Environmental factors may also lead to high visual contrast and cause myopia. Diffusion optics technology (DOT) lenses are designed to reduce contrast signalling in the retina and slow myopia progression. METHODS: The C ontrol of M y opia Using P eriphe r al Diffusion Lenses E fficacy and S afety S tudy (CYPRESS, NCT03623074) is a 36-month, multicentre, randomised, controlled, double-masked trial evaluating two investigational spectacle lenses versus control lenses in myopic children aged 6-10, with a planned interim analysis at 12 months...
November 2023: British Journal of Ophthalmology
https://read.qxmd.com/read/36100361/smoking-and-progressive-retinal-nerve-fibre-layer-thinning-in-glaucoma
#60
JOURNAL ARTICLE
Takashi Nishida, Golnoush Mahmoudinezhad, Robert N Weinreb, Sally L Baxter, Medi Eslani, Jeffrey M Liebmann, Christopher A Girkin, Massimo A Fazio, Linda M Zangwill, Sasan Moghimi
BACKGROUND/AIMS: To investigate the relationship between smoking and smoking intensity, and the rate of retinal nerve fibre layer (RNFL) thinning in patients with primary open angle glaucoma (POAG). METHODS: In this longitudinal study, patients with POAG who had at least 3 years of follow-up with a minimum of 5 visits of optical coherence tomography (OCT) were enrolled. The smoking intensity was calculated as the pack-year at the baseline OCT. Univariable and multivariable linear mixed models were used to determine the effect of each parameter on the rates of RNFL thinning over time...
November 2023: British Journal of Ophthalmology
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