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British Journal of Ophthalmology

Katrin Gekeler, Andreas Schatz, Manuel Dominik Fischer, Kai Schommer, Katrin Boden, Karl Ulrich Bartz-Schmidt, Florian Gekeler, Gabriel Willmann
BACKGROUND/AIMS: The aim of this study was to investigate a change in visual acuity and contrast sensitivity (CS) during high altitude exposure in healthy subjects due to the effects of hypobaric hypoxia. This study is related to the Tübingen High Altitude Ophthalmology study. METHODS: Visual acuity and Weber CS were tested monocularly using the Freiburger Visual Acuity and Contrast Test under standardised conditions in 14 healthy subjects at high altitude at the Capanna Margherita (4559 m, Italy) and compared with baseline measurements in Tübingen (341 m, Germany)...
February 15, 2019: British Journal of Ophthalmology
Zhixi Li, Ran Liu, Guangming Jin, Jason Ha, Xiaohu Ding, Wei Xiao, Xiao Xu, Lei An, Jialiang Zhao, Mingguang He
AIMS: To evaluate the prevalence of myopic maculopathy among participants aged 50 years and older in rural southern China. METHODS: Population-based, cross-sectional study. Subjects were recruited using cluster sampling from Yangxi County, Guangdong Province, China from August to November in 2014. Non-cycloplegic autorefraction and fundus photography were performed on all of the participants. Myopic maculopathy was graded based on fundus photographs using the International Classification of Myopic Maculopathy...
February 15, 2019: British Journal of Ophthalmology
Joseph Catapano, Simon S M Fung, William Halliday, Cecilia Jobst, Douglas Cheyne, Emily S Ho, Ronald M Zuker, Gregory H Borschel, Asim Ali
AIM: To report clinical outcomes and evidence of corneal innervation in patients with neurotrophic keratopathy (NK) treated with minimally invasive corneal neurotisation (MICN) using a sural nerve graft and donor sensory nerves from the face. METHODS: Patients undergoing MICN at The Hospital for Sick Children, Toronto, Canada were prospectively recruited. Data on central corneal sensation (CCS, measured with Cochet-Bonnet aesthesiometer), best-corrected visual acuity (BCVA) and corneal epithelial integrity were collected...
February 15, 2019: British Journal of Ophthalmology
Homayoun Tabandeh, Nikolas J S London, David S Boyer, Harry W Flynn
PURPOSE: To evaluate outcomes of small-gauge pars plana vitrectomy (PPV) for the treatment of rhegmatogenous retinal detachment (RD) without scleral-depressed shaving of the vitreous base. METHODS: Retrospective, consecutive case series. Surgical technique included small-gauge PPV (25G, 23G, 25G+ or 27G) and wide-angle vitrectomy viewing system in all cases. No cases were excluded based on the level of complexity of RD. Outcome measures were retinal reattachment rates and Snellen visual acuity (best-corrected visual activity [BCVA])...
February 15, 2019: British Journal of Ophthalmology
Lisa A Hark, Jonathan S Myers, Andrew Ines, Alicia Jiang, Kamran Rahmatnejad, Tingting Zhan, Benjamin E Leiby, Sarah Hegarty, Scott J Fudemberg, Anand V Mantravadi, Michael Waisbourd, Jeffrey D Henderer, Christine Burns, Meskerem Divers, Jeanne Molineaux, Laura T Pizzi, Ann P Murchison, Jinan Saaddine, Louis R Pasquale, Julia A Haller, L Jay Katz
AIMS: To evaluate agreement between ocular findings of a telemedicine eye screening (visit 1) with diagnoses of a comprehensive eye examination (visit 2). METHODS: A primary care practice (PCP)-based telemedicine screening programme incorporating fundus photography, intraocular pressure (IOP) and clinical information was conducted. Eligible individuals were African American, Hispanic/Latino or Asian over the age of 40; Caucasian individuals over age 65; and adults of any ethnicity over age 40 with a family history of glaucoma or diabetes...
February 15, 2019: British Journal of Ophthalmology
Shawn Rong Lin, Anthony J Aldave, James Chodosh
Recurrent corneal erosion syndrome (RCES) is a disorder characterised by a dysfunctional epithelial ecosystem. It often begins after trauma, or in the setting of epithelial basement membrane degeneration or dystrophy. Historically, RCES has been understood as a structural derangement of the anterior corneal architecture. More recently, studies have demonstrated the important role of neuropeptides in corneal homoeostasis. Thus, RCES may also be understood as a disorder of corneal epithelial cell biology. Management of RCES can be challenging, but newer therapies have demonstrated improved efficacy for this condition...
February 13, 2019: British Journal of Ophthalmology
Chen-Wei Pan, Chaofu Ke, Dan-Ning Hu, Jun Li, Hua Zhong
BACKGROUND/AIMS: Iris colour might contribute to refractive development, but it is uncertain whether it is related to astigmatism. We aim to examine the association of iris colour with the presence of astigmatism in a school-based sample of Chinese students. METHODS: 2346 grade 7 students from 10 middle schools aged 13 to 14 years in Southwestern China participated in the study. We obtained standardised slit-lamp photographs and developed a grading system assessing iris colour (higher grade denoting darker)...
February 11, 2019: British Journal of Ophthalmology
Hazel Squires, Iñigo Bermejo, Edith N Poku, Katy Cooper, John Stevens, Jean Hamilton, Ruth Wong, Alastair K Denniston, Ian Pearce, Fahd Mohammed Quhill
BACKGROUND: Uveitis is inflammation inside the eye. The objective of this study is to assess the cost-effectiveness of a dexamethasone implant plus current practice (immunosuppressants and systemic corticosteroids) compared with current practice alone, in patients with non-infectious intermediate, posterior or pan-uveitis and to identify areas for future research. METHODS: A Markov model was built to estimate the costs and benefits of dexamethasone. Systematic reviews were performed to identify available relevant evidence...
February 11, 2019: British Journal of Ophthalmology
Amy Gerrish, Edward Stone, Samuel Clokie, John R Ainsworth, Helen Jenkinson, Maureen McCalla, Carol Hitchcott, Isabel Colmenero, Stephanie Allen, Manoj Parulekar, Trevor Cole
Retinoblastoma is the most common eye malignancy in childhood caused by mutations in the RB1 gene. Both alleles of the RB1 gene must be mutated for tumour development. The initial RB1 mutation may be constitutional germline or somatic (originating in one retinal cell only). Distinguishing between these alternative mechanisms is crucial, with wider implications for management of the patient and family members. Bilateral retinoblastoma is nearly always due to a constitutional mutation; however, approximately 15% of unilateral cases also carry a germline mutation, and identifying these cases is important...
February 11, 2019: British Journal of Ophthalmology
Siofra Christine Harrington, Jim Stack, Veronica O'Dwyer
AIM: To examine the demographic and social factors associated with myopia in schoolchildren in Ireland. METHODS: Thirty-seven schools participated, representing a mix of urban and rural schools and schools in socioeconomically disadvantaged and non-disadvantaged areas in Ireland. Examination included cyclopleged autorefraction (1% cyclopentolate hydrochloride). Height and weight of participants were measured. Parents filled in a participant's lifestyle questionnaire, including questions on daily screen time use and daylight exposure...
February 11, 2019: British Journal of Ophthalmology
Claudia Becker, Susan S Jick, Christoph R Meier
BACKGROUND/AIM: Use of ACE inhibitors (ACEIs) has been associated with an increased risk of cataract in a previous observational study in humans. In contrast, ACEIs were associated with beneficial effects on cataract development in experimental studies. We assessed the risk of cataract in relation to exposure to ACEI and other antihypertensive drugs. METHODS: This is a case-control study based on data from the UK-based Clinical Practice Research Datalink (CPRD)...
February 7, 2019: British Journal of Ophthalmology
Thaís Shiota Tanaka, Christopher Thomas Hood, Matthias Frank Kriegel, Leslie Niziol, H Kaz Soong
BACKGROUND/AIM: To review the long-term outcomes of penetrating keratoplasty (PKP) for corneal complications of herpes zoster ophthalmicus (HZO). METHODS: We reviewed the medical records of 53 eyes of 53 patients who underwent PKP due to corneal complications of HZO at the Kellogg Eye Center. RESULTS: The mean age of patients at the time of PKP was 68.0±16.4 years, with a follow-up of 4.0±3.8 years and quiescent period of 6.5±5.3 years from active HZO to PKP...
February 7, 2019: British Journal of Ophthalmology
Inigo Bermejo, Hazel Squires, Edith N Poku, Katy Cooper, John W Stevens, Jean Hamilton, Ruth Wong, Ian Pearce, Fahd Mohammed Quhill, Alastair K Denniston
BACKGROUND/AIMS: Uveitis is inflammation inside the eye. Our objective was to assess the cost-effectiveness of adalimumab compared with current practice (immunosuppressants and systemic corticosteroids) in patients with non-infectious intermediate, posterior or panuveitis and to identify areas for future research. METHODS: A Markov model was built to estimate costs and benefits of the interventions. Systematic reviews were performed to identify the available relevant clinical and cost-effectiveness evidence...
February 6, 2019: British Journal of Ophthalmology
Ana I M Miguel, André B Silva, Luis F Azevedo
BACKGROUND: Compared with current imaging methods, the diagnostic performance and the advantages and limitations of optical coherence tomography angiography (OCTA) remain unclear. We performed a systematic review and meta-analysis of studies investigating vessel density (VD) in patients with glaucoma using OCTA. METHODS: We conducted a literature search on PubMed, Scopus, Web of Science, ISI Conference Proceedings and Google Scholar, along with a manual search, from January 2006 to March 2018...
February 6, 2019: British Journal of Ophthalmology
Neelam Kumari, Mayuri Bhargava, Duc Quang Nguyen, Alfred Tau Liang Gan, Gavin Tan, Ning Cheung, Nicholas Tan, Charlene Wong, Jie Jin Wang, Paul Mitchell, Ecosse L Lamoureux, Ching Yu Cheng, Tien Yin Wong, Charumathi Sabanayagam
AIMS: Diabetes is a major public health problem in migrants and ethnic minorities worldwide. We determined the incidence and risk factors of diabetic retinopathy (DR) in migrant Indians living in Singapore. METHODS: We included data from 759 Indian adults with diabetes, who participated in the baseline (aged 40-80 years, 2007-2009) and 6-year follow-up 2012-2015 of the Singapore Indian Eye Study. Retinal photographs were graded for the presence and severity of DR using modified Airlie House Classification...
February 2, 2019: British Journal of Ophthalmology
Terence Joseph McSwiney, Susan J Knowles, Conor C Murphy
BACKGROUND/AIMS: To describe the risk factors, clinical features, bacterial subspecies characteristics and treatment outcomes of Moraxella keratitis in a single centre. METHODS: A retrospective review of all patients diagnosed with Moraxella keratitis between November 2012 and December 2017 at the Royal Victoria Eye and Ear Hospital, Dublin, Ireland was performed. Matrix-assisted laser desorption ionisation time-of-flight (MALDI-TOF) mass spectrometry was used to identify Moraxella subspecies...
February 1, 2019: British Journal of Ophthalmology
Miin Roh, Inês Laíns, Hyun Joon Shin, Dong Ho Park, Steven Mach, Demetrios G Vavvas, Ivana K Kim, Joan W Miller, Deeba Husain, John B Miller
BACKGROUND/AIMS: Microperimetry is a technique that is increasingly used to assess visual function in age-related macular degeneration (AMD). In this study, we aimed to evaluate the relationship between retinal sensitivity measured with macular integrity assessment (MAIA) microperimetry and optical coherence tomography (OCT)-based macular morphology in AMD. METHODS: Prospective, cross-sectional study. All participants were imaged with colour fundus photographs used for AMD staging (Age-Related Eye Disease Study scale), spectral-domain OCT (Spectralis, Heidelberg, Germany) and swept-source OCT (Topcon, Japan)...
February 1, 2019: British Journal of Ophthalmology
Martina C Herwig-Carl, Hans E Grossniklaus, Philipp L Müller, Lisa Atzrodt, Karin U Loeffler, Claudia Auw-Haedrich
AIMS: To systematically describe the clinical and histopathological features of a case series of conjunctival carcinomatous lesions underlying as-and also masquerading-pyogenic granuloma. METHODS: Nine cases of conjunctival carcinomatous lesions underlying a pyogenic granuloma (which were clinically predominant) were retrospectively identified. Patients' records were analysed for demographic data, clinical appearance and the postoperative course. Formalin-fixed paraffin-embedded specimens were routinely processed and stained with H&E and periodic acid-Schiff...
February 1, 2019: British Journal of Ophthalmology
Alessandro Marchese, Elisabetta Miserocchi, Chiara Giuffrè, Maria Vittoria Cicinelli, Giuseppe Querques, Francesco Bandello, Giulio Modorati
AIMS: Peculiar retinal signs of vitreoretinal lymphoma (VRL) have been identified. However, limited information on the vitreous features of VRL is available. This study aims to characterise the vitreous involvement in VRL with the help of multimodal imaging. METHODS: In this retrospective, observational study, we reviewed charts and imaging of all patients with biopsy-proven VRL seen from January 2016 to April 2018 at a single referral centre. These included ultrawide-field imaging, ophthalmic ultrasonography and slit-lamp photography...
February 1, 2019: British Journal of Ophthalmology
Su-Kyung Jung, Ji-Sun Paik, Gyeong-Sin Park, Seok-Goo Cho, Suk-Woo Yang
PURPOSE: To report the clinical manifestations of 199 patients with suspected conjunctival lymphoma, the associations between these features and the pathological diagnoses, and the prognosis of conjunctival lesions during long-term follow-up. METHODS: We conducted a retrospective chart review of 199 patients who underwent conjunctival biopsy on suspicion of conjunctival lymphoproliferative disease between January 2008 and June 2015. We focused on slit-lamp findings in the conjunctiva and the pathological diagnoses...
February 1, 2019: British Journal of Ophthalmology
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