Julia M Weller, Lisa Hübner, Friedrich E Kruse, Theofilos Tourtas
BACKGROUND/AIMS: Ectasia of the cornea can occur decades after penetrating keratoplasty (PK), especially in keratoconus eyes. The purpose of this study was to characterise ectasia after PK by morphological findings in anterior segment optical coherence tomography (AS-OCT). METHODS: In this retrospective, single-centre case series, 50 eyes of 32 patients with a history of PK at an average of 25±10 years earlier were included. The eyes were classified either as ectatic (n=35) or as non-ectatic (n=15)...
March 20, 2023: British Journal of Ophthalmology
Murat Hasanreisoglu, Muhammad Sohail Halim, Pinar Cakar Ozdal, Maria Soledad Ormaechea, Cem Kesim, Huseyin Baran Ozdemir, Gunay Uludag, Nripun Sredar, Mahmut Cankurtaran, Xiaoxuan Liu, Alastair Keith Denniston, Marcelo N Rudzinski, Daniel N Colombero, Bernardo Ariel Schlaen, Pearse Andrew Keane, Carlos Pavesio, Quan Dong Nguyen
BACKGROUND: To establish topographic maps and determine fundus distribution patterns of ocular toxoplasmosis (OT) lesions. METHODS: In this retrospective study, patients who presented with OT to ophthalmology clinics from four countries (Argentina, Turkey, UK, USA) were included. Size, shape and location of primary (1°)/recurrent (2°) and active/inactive lesions were converted into a two-dimensional retinal chart by a retinal drawing software. A final contour map of the merged image charts was then created using a custom Matlab programme...
March 17, 2023: British Journal of Ophthalmology
Yingxiu Luo, Mingpeng Xu, Ludi Yang, Yiran Yao, Jesse L Berry, Liya Xu, Xuyang Wen, Xiaoyu He, Minglei Han, Xianqun Fan, Jiayan Fan, Renbing Jia
UNLABELLED: BackgroundThis study determined to probe the potential association between somatic copy number alteration (SCNA) in retinoblastoma (RB) aqueous humour (AH) and pathological high-risk factors, clinical features and previous chemotherapy history. METHODS: Single-centre retrospective cohort study from including 58 AH samples collected from 58 patients diagnosed. Among them, 41 samples were collected after enucleation and 17 samples were collected before intravitreal chemotherapy...
March 17, 2023: British Journal of Ophthalmology
Vishal Balasubramanian Swaminathan, Mirataollah Salabati, Rachel Israilevich, Eli Cehelyk, Raziyeh Mahmoudzadeh, Joshua H Uhr, Marc J Spirn, Michael A Klufas, Sunir J Garg, Jason Hsu
AIM: To report anatomical and functional outcomes after surgical repair of acute-onset vs delayed-onset rhegmatogenous retinal detachments (RDs) following acute posterior vitreous detachment (PVD). METHODS: A retrospective, comparative interventional cohort study where patients presenting to a single-centre retina practice between October 2015 and March 2020 with delayed RDs (diagnosed ≥42 days after initial presentation of acute PVD) were compared with a 2:1 age-matched and gender-matched acute RD cohort (PVD and RD at initial presentation)...
March 14, 2023: British Journal of Ophthalmology
Seema Kashyap, Mithalesh Kumar Singh, Nikhil Kumar, Jayanti Jha, Neiwete Lomi, Rachna Meel, Sameer Bakhshi, Seema Sen, Lata Singh
UNLABELLED: BackgroundResponse rate of PD-1/PD-L1 immunotherapeutic blockade agents in uveal melanoma (UM) is poor. Lymphocyte activation gene 3 (LAG3) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) are the two promising immune checkpoint targets. Therefore, our aim was to explore at how these proteins were expressed in tumour tissue and serum, as well as their prognostic implications in UM. METHODS: The expression of LAG3, CTLA-4, CD3, CD4, CD8 and FOXP3 was determined by immunohistochemistry in 54 enucleated UM tissue samples...
March 14, 2023: British Journal of Ophthalmology
Shanthala Sreenivasa, Markus Wösle, Yann Gager, Dirk Vordermark, Luise Grajewski, Lothar Krause, I Frank Ciernik
BACKGROUND/AIMS: Primary radiation therapy is used to treat malignant uveal melanoma (UM). We report our single-centre experience with fractionated radiosurgery (fSRS) with a linear accelerator (LINAC) after specific adaptation for small target volumes with HybridArc. METHODS: From October 2014 to January 2020, 101 patients referred to Dessau City Hospital with unilateral UM underwent fSRS with 50 Gy given in five fractions on five consecutive days. Primary endpoints were local tumour control, globe preservation, metastasis and death...
March 9, 2023: British Journal of Ophthalmology
Chufeng Gu, Yujie Wang, Yan Jiang, Feiping Xu, Shasha Wang, Rui Liu, Wen Yuan, Nurbiyimu Abudureyimu, Ying Wang, Yulan Lu, Xiaolong Li, Tao Wu, Li Dong, Yuzhong Chen, Bin Wang, Yuncheng Zhang, Wen Bin Wei, Qinghua Qiu, Zhi Zheng, Deng Liu, Jili Chen
BACKGROUND/AIMS: This study evaluates the performance of the Airdoc retinal artificial intelligence system (ARAS) for detecting multiple fundus diseases in real-world scenarios in primary healthcare settings and investigates the fundus disease spectrum based on ARAS. METHODS: This real-world, multicentre, cross-sectional study was conducted in Shanghai and Xinjiang, China. Six primary healthcare settings were included in this study. Colour fundus photographs were taken and graded by ARAS and retinal specialists...
March 6, 2023: British Journal of Ophthalmology
Yuwen Liu, Changsheng Xu, Shaopan Wang, Yuguang Chen, Xiang Lin, Shujia Guo, Zhaolin Liu, Yuqian Wang, Houjian Zhang, Yuli Guo, Caihong Huang, Huping Wu, Ying Li, Qian Chen, Jiaoyue Hu, Zhiming Luo, Zuguo Liu
BACKGROUND/AIMS: To improve the accuracy of pterygium screening and detection through smartphones, we established a fusion training model by blending a large number of slit-lamp image data with a small proportion of smartphone data. METHOD: Two datasets were used, a slit-lamp image dataset containing 20 987 images and a smartphone-based image dataset containing 1094 images. The RFRC (Faster RCNN based on ResNet101) model for the detection model. The SRU-Net (U-Net based on SE-ResNeXt50) for the segmentation models...
March 1, 2023: British Journal of Ophthalmology
Edward J Casswell, Suzie Cro, Victoria R Cornelius, Philip J Banerjee, Tapiwa M Zvobgo, Rhiannon Tudor Edwards, Victory Ezeofor, Bethany Anthony, Syed Mohammed Shahid, Catey Bunce, Joanna Kelly, Caroline Murphy, Elizabeth Robertson, David Charteris
BACKGROUND/AIMS: To investigate the clinical effectiveness of adjunctive triamcinolone acetonide (TA) given at the time of vitreoretinal surgery following open globe trauma (OGT). METHODS: A phase 3, multicentre, double-masked randomised controlled trial of patients undergoing vitrectomy following OGT comparing adjunctive TA (intravitreal and subtenons) against standard care (2014-2020). The primary outcome was the proportion of patients with at least 10 Early Treatment Diabetic Retinopathy Study (ETDRS) letter improvement in corrected visual acuity (VA) at 6 months...
February 27, 2023: British Journal of Ophthalmology
Jinghui Wang, Xianghua Wu, Qiwei Wang, Fengqi Zhou, Hui Chen, Wan Chen, Duoru Lin, Xiayin Zhang, Ruixin Wang, Jingjing Chen, Zhenzhen Liu, Zhuoling Lin, Xiaoyan Li, Jing Li, Ying Han, Yizhi Liu, Haotian Lin, Weirong Chen
AIMS: To report the incidence and associated risk factors for developing suspected and definitive glaucoma after bilateral congenital cataract (CC) removal with a 5-year follow-up. METHODS: Secondary analysis of a prospective longitudinal cohort study. Bilateral CC patients who had undergone cataract surgery between January 2011 and December 2014 at Zhongshan Ophthalmic Centre were recruited. Suspected glaucoma was defined as persistent ocular hypertension requiring medical treatment...
February 24, 2023: British Journal of Ophthalmology
Wendy Meihua Wong, Wu Sun, Chinmayi Vyas, Angie Hon Chi Fong, Caroline K Chee, Xin Yi Su, Kelvin Yc Teo, Chui Ming Gemmy Cheung
AIM: To describe the clinical characteristics in a cohort of patients with the pachychoroid phenotype and to evaluate the association of ocular and systemic factors with type of complications observed. METHODS: We report baseline findings from a prospective observational study which recruited subjects with subfoveal choroidal thickness (SFCT) of ≥300 µm on spectral-domain optical coherence tomography (OCT). Multimodal imaging was used to classify eyes as uncomplicated pachychoroid (UP) or pachychoroid disease with pachychoroid pigment epitheliopathy (PPE), central serous chorioretinopathy (CSC) or pachychoroid neovasculopathy (PNV) subtypes...
February 21, 2023: British Journal of Ophthalmology
Sapna Gangaputra, Craig Newcomb, Rebecca Armour, Dongseok Choi, Gui-Shuang Ying, Sylvia Groth, Hosne Begum, Tonetta Fitzgerald, Pichaporn Artornsombudh, Ebenezer Daniel, Nirali Bhatt, Stephen Foster, Douglas Jabs, Grace Levy-Clarke, Robert Nussenblatt, James T Rosenbaum, H Nida Sen, Eric Suhler, Jennifer Thorne, Kurt Dreger, Jeanine Buchanich, John H Kempen
PURPOSE: To evaluate the long-term visual acuity (VA) outcome of cataract surgery in inflammatory eye disease. SETTING: Tertiary care academic centres. DESIGN: Multicentre retrospective cohort study. METHODS: A total of 1741 patients with non-infectious inflammatory eye disease (2382 eyes) who underwent cataract surgery while under tertiary uveitis management were included. Standardised chart review was used to gather clinical data...
February 21, 2023: British Journal of Ophthalmology
Eleonora Micheletti, Nevin El-Nimri, Takashi Nishida, Sasan Moghimi, Jasmin Rezapour, Massimo A Fazio, Min Hee Suh, Christopher Bowd, Akram Belghith, Mark Christopher, Jost B Jonas, Robert N Weinreb, Linda M Zangwill
PURPOSE: To characterise the relationship between a deep-layer microvasculature dropout (MvD) and central visual field (VF) damage in primary open-angle glaucoma (POAG) patients with and without high axial myopia. DESIGN: Cross-sectional study. METHODS: Seventy-one eyes (49 patients) with high axial myopia and POAG and 125 non-highly myopic POAG eyes (97 patients) were enrolled. Presence, area and angular circumference of juxtapapillary MvD were evaluated on optical coherence tomography angiography B-scans and en-face choroidal images...
February 20, 2023: British Journal of Ophthalmology
Senlin Lin, Bijun Zhu, Ting Wang, Hong Wang, Xian Xu, Shanshan Wang, Yao Yin, Zhaoyu Xiang, Yu Qian, Zhang Zhang, Lipu Cui, Haidong Zou, Xiangui He, Jianfeng Zhu, Yingyan Ma
BACKGROUND/AIMS: We aim to explore the effect of sympathetic nervous system (SNS) on choroid thickness (ChT) and axial length (AL). METHODS: Students of grade 2 and 3 from a primary school were included and followed for 1 year. Visual acuity, refraction, AL and ChT were measured. Morning urine samples were collected for determining SNS activity by analysing concentrations of epinephrine, norepinephrine and dopamine using the liquid chromatography-tandem mass spectrometry...
February 14, 2023: British Journal of Ophthalmology
Nicolas Leveziel, Simon Marillet, Tasanee Braithwaite, Tunde Peto, Pierre Ingrand, Shahina Pardhan, Alain M Bron, Jost B Jonas, Serge Resnikoff, Little Julie Anne, Adrian C Davis, Catherine M McMahon, Rupert R A Bourne
BACKGROUND: Data on population-based self-reported dual vision and hearing impairment are sparse in Europe. We aimed to investigate self-reported dual sensory impairment (DSI) in European population. METHODS: A standardised questionnaire was used to collect medical and socio-economic data among individuals aged 15 years or more in 29 European countries. Individuals living in collective households or in institutions were excluded from the survey. RESULTS: Among 296 677 individuals, the survey included 153 866 respondents aged 50 years old or more...
February 9, 2023: British Journal of Ophthalmology
Sonia Moorthy, Gillian G W Adams, Graham Smith, Susmito Biswas, Waleed Aliyan, Roshni Bhudia, Aamir Saiyed, Shad Husain
No abstract text is available yet for this article.
February 9, 2023: British Journal of Ophthalmology
Zhi-Qi Ying, Dan-Lin Li, Xin-Yu Zheng, Xiao-Feng Zhang, Chen-Wei Pan
AIMS: To identify potential risk factors for myopia in children and adolescents and assess the credibility of each evidence, providing reference for the development of myopia prevention strategies. METHODS: We searched PubMed, Web of Science and Embase databases from inception to April 2022 to find systematic reviews or meta-analyses investigating the relationship between potential risk factors and myopia, and conducted an umbrella review. We recalculated the pooled effect sizes and 95% CIs of each potential risk factor through random-effects model, and reported its 95% prediction interval and between-study heterogeneity...
February 8, 2023: British Journal of Ophthalmology
Mark A Chia, Fred Hersch, Rory Sayres, Pinal Bavishi, Richa Tiwari, Pearse A Keane, Angus W Turner
BACKGROUND/AIMS: Deep learning systems (DLSs) for diabetic retinopathy (DR) detection show promising results but can underperform in racial and ethnic minority groups, therefore external validation within these populations is critical for health equity. This study evaluates the performance of a DLS for DR detection among Indigenous Australians, an understudied ethnic group who suffer disproportionately from DR-related blindness. METHODS: We performed a retrospective external validation study comparing the performance of a DLS against a retinal specialist for the detection of more-than-mild DR (mtmDR), vision-threatening DR (vtDR) and all-cause referable DR...
February 6, 2023: British Journal of Ophthalmology
Mohammed Rigi, Hyeck-Soo Son, Loren Moon, Mario Matthaei, Divya Srikumaran, Albert S Jun, Charles G Eberhart, Uri S Soiberman
PURPOSE: Corneal biomechanical failure is the hallmark of keratoconus (KC); however, the cause of this failure remains elusive. Collagen type XII ( COL12A1 ), which localises to Bowman's layer (BL), is thought to function in stress-bearing areas, such as BL. Given the putative protective role of COL12A1 in biomechanical stability, this study aims to characterise COL12A1 expression in all corneal layers involved in KC. METHODS: TaqMan quantitative PCR was performed on 31 corneal epithelium samples of progressive KC and myopic control eyes...
February 6, 2023: British Journal of Ophthalmology
Chenxi Yan, Yibo Yu, Wei Wang, Ying Han, Ke Yao
AIM: To compare lens extraction (LE) and laser peripheral iridotomy (LPI) on anterior segment morphology in primary angle-closure suspect (PACS) eyes. METHODS: This prospective clinical trial included 144 patients with PACS who underwent either LPI or LE. Ultrasound biomicroscopy (UBM) and gonioscopy were performed before and 1 month and 2 years after operation. Main outcomes included UBM parameters and the percentage of residual angle closure. RESULTS: At both 1 month and 2 years of follow-up, LE showed a better effect of relieving anterior chamber crowding and widening the drainage angle, as obtaining a larger anterior chamber depth (ACD), angle opening distance, trabecular iris angle (TIA), trabecular iris space area, trabecular ciliary process distance (TCPD) and a smaller iris curvature (I-Curv) and lens vault (LV) (p<0...
February 6, 2023: British Journal of Ophthalmology
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