Ryan Van Laar, Babak Latif, Sam King, Christopher Love, Nadine Taubenheim, Esha Kalanooriya, Wandi Wang, Mirette Saad, Ingrid Winship, Anthony Azzi, Alister Lilleyman, Tony Landgren
IMPORTANCE: Non-invasive molecular biomarkers are needed to improve the early, accurate and precise diagnosis of invasive cutaneous melanoma. OBJECTIVE: To independently validate a previously-identified circulating microRNA signature of melanoma (MEL38). Secondly, to develop of a complementary microRNA signature, optimized for prognostication. DESIGN, SETTING & PARTICIPANTS: MicroRNA expression profiling was performed on plasma samples from a multi-centre observational case-control study, involving patients with primary or metastatic melanoma, melanoma in-situ, non-melanoma skin cancer, or benign nevi...
May 5, 2023: British Journal of Dermatology