British Journal of Dermatology

BACKGROUND: Effective treatment options for patients with chronic hand eczema (CHE) are scarce. Dupilumab is licensed for the treatment of moderate-to-severe atopic dermatitis and has shown promising results on hand eczema in other studies. OBJECTIVE: To evaluate the efficacy and safety of dupilumab in adult patients with severe CHE (subtypes recurrent vesicular HE or chronic fissured HE) with an inadequate response/intolerance to alitretinoin, or when alitretinoin is medically inadvisable...

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BACKGROUND: There is limited understanding of the epidemiology of generalised pustular psoriasis (GPP) internationally, with no population-based estimates of GPP in Southeast Asia. OBJECTIVES: To determine the incidence and prevalence of GPP in the Malaysian population and characterise its flares and trigger factors. METHODS: A population-based cohort study using the Teleprimary Care database between January 2010 and December 2020. We identified 230 dermatologist-confirmed GPP cases by ICD-10 diagnostic codes...

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No abstract text is available yet for this article.

Monkeypox (mpox) is a disease caused by a double-stranded DNA orthopoxvirus discovered in 1958. In 2022 an outbreak on an unprecedented scale marked its transition from neglected, zoonotic disease circulating almost exclusively within African borders to sexually transmitted infection (STI) of international concern. Although phylogenetic evidence suggests progressive evolution from the strain associated with the 2018 outbreak in Nigeria, epidemiological links with previous cases are still incompletely elucidated...

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No abstract text is available yet for this article.

IMPORTANCE: Non-invasive molecular biomarkers are needed to improve the early, accurate and precise diagnosis of invasive cutaneous melanoma. OBJECTIVE: To independently validate a previously-identified circulating microRNA signature of melanoma (MEL38). Secondly, to develop of a complementary microRNA signature, optimized for prognostication. DESIGN, SETTING & PARTICIPANTS: MicroRNA expression profiling was performed on plasma samples from a multi-centre observational case-control study, involving patients with primary or metastatic melanoma, melanoma in-situ, non-melanoma skin cancer, or benign nevi...

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BACKGROUND: Vitiligo is an autoimmune skin disorder characterized by loss of melanocytes. Protease-mediated disruption of junctions between keratinocytes and/or keratinocyte intrinsic dysfunction may directly contribute to melanocyte loss. House dust mite (HDM), an environmental allergen with potent protease activity, contributes to respiratory and gut disease but also to atopic dermatitis and rosacea. OBJECTIVE: To verify if HDM can contribute to melanocyte detachment in vitiligo and if so, by which mechanism(s)...

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BACKGROUND: Hidradenitis suppurativa is an inflammatory disease of the inverse skin regions that occurs particularly in young women and affects approximately 1% of the population. Outpatient care is often inadequate and usually cannot prevent progression. OBJECTIVE: The aim of the EsmAiL trial was to evaluate whether an innovative care concept can decrease disease activity and burden, as well as improve patient satisfaction. METHODS: EsmAiL was conducted as a two-arm, multicentre, prospective randomised controlled trial including 553 adults with HS...

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No abstract text is available yet for this article.

No abstract text is available yet for this article.