Carsten Flohr, Anna Rosala-Hallas, Ashley P Jones, Paula Beattie, Susannah Baron, Fiona Browne, Sara J Brown, Joanna E Gach, Danielle Greenblatt, Ross Hearn, Eva Hilger, Ben Esdaile, Michael J Cork, Emma Howard, Marie-Louise Lovgren, Suzannah August, Farhiya Ashoor, Paula R Williamson, Tess McPherson, Donal O'Kane, Jane Ravenscroft, Lindsay Shaw, Manish D Sinha, Catherine Spowart, Leonie S Taams, Bjorn R Thomas, Mandy Wan, Tracey H Sach, Alan D Irvine
BACKGROUND: Conventional systemic drugs are used to treat children and young people (CYP) with severe atopic dermatitis (AD) worldwide, but no robust RCT evidence exists regarding their efficacy and safety in this population. While novel therapies have expanded therapeutic options, their high cost means traditional agents remain important, especially in lower resource settings. OBJECTIVES: The TREAT trial compared the safety and efficacy of ciclosporin (CyA) versus methotrexate (MTX) in CYP with severe AD...
September 19, 2023: British Journal of Dermatology