journal
https://read.qxmd.com/read/36961272/intravesical-oncolytic-virotherapy-and-immunotherapy-for-non-muscle-invasive-bladder-cancer-mouse-model
#1
JOURNAL ARTICLE
Woodson W Smelser, Jian Wang, Kristen M Ogden, Sam S Chang, Austin N Kirschner
OBJECTIVES: Non-muscle-invasive bladder cancer that is refractory to intravesical Bacillus Calmette-Guérin (BCG) may be treated by systemic anti-PD-1 (programmed cell death protein 1) immunotherapy. We previously demonstrated improved overall survival with 6 weekly instillations of intravesical anti-PD-1 in a murine model. The objective of this work is to test if intravesical instillation of both an anti-PD-1 inhibitor and an oncolytic reovirus would demonstrate a greater effect than either treatment alone...
March 24, 2023: BJU International
https://read.qxmd.com/read/36961256/voiding-and-renal-functions-ten-years-after-radical-cystectomy-and-orthotopic-neobladder-in-females
#2
JOURNAL ARTICLE
Mohamed H Zahran, Ahmed M Harraz, Mohamed A Baset, Ramy El-Baz, Atallah A Shaaban, Bedeir Ali-El-Dein
OBJECTIVES: To assess long-term voiding and renal function (RF) changes after radical cystectomy (RC) and orthotopic neobladder (ONB) in females without disease recurrence. MATERIAL AND METHODS: Female patients who underwent RC and ONB from 1995 and 2011 were included. Patients who developed disease failure or lost follow-up were excluded. The study outcomes were long-term voiding function and the incidence and predictors of RF deterioration (defined by > 20% decline of baseline)...
March 24, 2023: BJU International
https://read.qxmd.com/read/36951507/authorship-diversity-in-global-evidence-synthesis-in-urology-1998-2022-analysis-of-cochrane-reviews
#3
JOURNAL ARTICLE
Ahmad Ozair, Abhishek Kumar, Nishanth R Subash, Sahaam Mirza, Atulya A Khosla, Manmeet Ahluwalia, Philipp Dahm
No abstract text is available yet for this article.
March 23, 2023: BJU International
https://read.qxmd.com/read/36932928/risks-and-benefits-of-partial-nephrectomy-with-limited-or-without-ischemia-time
#4
JOURNAL ARTICLE
Daniele Cignoli, Giuseppe Basile, Giuseppe Fallara, Giuseppe Rosiello, Federico Belladelli, Francesco Cei, Giacomo Musso, Chiara Re, Roberto Bertini, Pierre Karakiewicz, Alexandre Mottrie, Federico Dehò, Andrea Gallina, Francesco Montorsi, Andrea Salonia, Umberto Capitanio, Alessandro Larcher
OBJECTIVES: Controversial findings have been shown about the effect of warm ischemia time (WIT) on renal function in patients undergoing partial nephrectomy (PN). Specifically, it is unclear whether the surgical risk of performing off-clamp PN overcomes its beneficial effect on kidney function after surgery. In consequence, we tested the hypothesis that longer WIT might have a marginal impact on renal functional outcomes and, on the contrary, might reduce the hemorrhagic risk intraoperatively...
March 18, 2023: BJU International
https://read.qxmd.com/read/36919875/eve-s-and-adam-s-rib-for-prostate-cancer-screening
#5
EDITORIAL
Massimo Lazzeri, Vittorio Fasulo, Corrado Tinterri
No abstract text is available yet for this article.
March 15, 2023: BJU International
https://read.qxmd.com/read/36919248/transurethral-ventral-buccal-mucosa-graft-inlay-urethroplasty-technique-and-intermediate-outcomes
#6
JOURNAL ARTICLE
Joshua Sterling, Michael Daneshvar, Dmitriy Nikolavsky
No abstract text is available yet for this article.
March 14, 2023: BJU International
https://read.qxmd.com/read/36917033/ejaculatory-function-following-transperineal-laser-ablation-versus-turp-for-benign-prostatic-obstruction-a-randomized-trial
#7
JOURNAL ARTICLE
Riccardo Bertolo, Valerio Iacovelli, Chiara Cipriani, Marco Carilli, Matteo Vittori, Michele Antonucci, Francesco Maiorino, Marta Signoretti, Filomena Petta, Stefano Travaglia, Massimo Panei, Pierluigi Bove
OBJECTIVES: To evaluate the reliability of trans-perineal laser ablation of prostate (TPLA) in preserving antegrade ejaculation compared to trans-urethral resection of prostate (TURP). PATIENTS AND METHODS: In this single-center, prospective, randomized, open-label study, consecutive patients with indication to surgical treatment for benign prostatic obstruction (BPO) were enrolled between January 2020 and September 2021 (NCT04781049). Randomization defined two treatment arms: Group A: patients assigned to TPLA (experimental); Group B: patients assigned to TURP (standard)...
March 14, 2023: BJU International
https://read.qxmd.com/read/36896889/letter-to-the-editor-regarding-the-article-do-we-need-repeat-transurethral-resection-after-en-bloc-resection-for-pathological-t1-bladder-cancer
#8
LETTER
Huseyin Besiroglu
No abstract text is available yet for this article.
March 10, 2023: BJU International
https://read.qxmd.com/read/36880941/response-to-comment-on-environmental-impact-of-single-use-and-reusable-flexible-cystoscopes
#9
LETTER
Jayson Kemble, Kevin Koo
No abstract text is available yet for this article.
March 7, 2023: BJU International
https://read.qxmd.com/read/36880114/focal-irreversible-electroporation-for-treatment-of-primary-and-radio-recurrent-prostate-cancer-the-evidence-is-mounting
#10
EDITORIAL
John W Yaxley
No abstract text is available yet for this article.
March 6, 2023: BJU International
https://read.qxmd.com/read/36877951/financial-toxicity-from-newly-approved-second-third-line-agents-in-metastatic-urothelial-carcinoma
#11
JOURNAL ARTICLE
David J Benjamin, Mark P Lythgoe, Arash Rezazadeh
No abstract text is available yet for this article.
March 6, 2023: BJU International
https://read.qxmd.com/read/36877934/the-effect-of-different-assays-on-prostate-specific-antigen-testing
#12
LETTER
Anika Jain, Anthony-Joe Nassour, James L Symons, Amanda Chung, Ahmed S Goolam, Michael P Wines, Venu Chalasani, Max Dias, Ruth Collins, Bala Indrajit, Henry H Woo
No abstract text is available yet for this article.
March 6, 2023: BJU International
https://read.qxmd.com/read/36866941/same-day-discharge-robot-assisted-laparoscopic-prostatectomy-feasibility-safety-patient-experience
#13
JOURNAL ARTICLE
G T Hill, M Jeyanthi, W Coomer, R J Bryant, M T Colmsee, J Tozer, A C Cox, J R Wilson
OBJECTIVES: To report a single centre's experience of the feasibility, safety and patient acceptability of same day discharge Robot-Assisted Laparoscopic Prostatectomy (RALP). SUBJECTS/PATIENTS AND METHODS: Between June 2015 and December 2021, a total of 180 pre-selected consecutive patients underwent RALP with the intention to discharge on the same day as surgery. Cases were performed by two surgeons. An Enhanced Recovery After Surgery (ERAS) programme was utilised...
March 3, 2023: BJU International
https://read.qxmd.com/read/36855895/accurate-diagnosis-of-prostate-cancer-by-combining-proclarix-with-magnetic-resonance-imaging
#14
JOURNAL ARTICLE
Juan Morote, Hayley Pye, Miriam Campistol, Anna Celma, Lucas Regis, Maria Semidey, Ines de Torres, Richard Mast, Jacques Planas, Anna Santamaria, Enrique Trilla, Alcibiade Athanasiou, Saurabh Singh, Susan Heavey, Urszula Stopka-Farooqui, Alex Freeman, Aiman Haider, Ralph Schiess, Hayley C Whitaker, Shonit Punwani, Hashim U Ahmed, Mark Emberton
OBJECTIVES: The use of mpMRI has been a significant advance in the diagnosis of clinically significant prostate cancer (ISUP Grade Group ≥2, csPCa) and is recommended in most current guidelines. Proclarix® is a novel CE-marked biomarker test aiding in the identification of csPCa. The aim of the study was the assessment of the clinical performance of Proclarix alone or in combination with mpMRI to predict csPCa. PATIENTS AND METHODS: The study included blood samples from 721 men undergoing mpMRI followed by biopsy at University College London (UCL), London, and Vall d'Hebron University Hospital, Barcelona...
March 1, 2023: BJU International
https://read.qxmd.com/read/36847603/standardized-prostate-cancer-incidence-and-mortality-rates-following-initial-non-malignant-biopsy-result
#15
JOURNAL ARTICLE
Hein V Stroomberg, Marc C M Andersen, J Thomas Helgstrand, Signe Benzon Larsen, Andrew J Vickers, Klaus Brasso, Andreas Røder
OBJECTIVES: To compare the incidence of subsequent prostate cancer diagnosis and death following an initial non-malignant systematic TRUS biopsy to an age- and calendar-year matched population over a 20-year period. SUBJECTS AND METHODS: This population-based analysis compares a cohort of all men with initial non-malignant TRUS biopsy in Denmark between 1995-2016 (N=37,231) to the Danish population matched by age and calendar year, obtained from the NORDCAN 9.1 database...
February 27, 2023: BJU International
https://read.qxmd.com/read/36820507/comment-on-environmental-impact-of-single-use-and-reusable-flexible-cystoscopes
#16
LETTER
Michael Baboudjian, Cyrille Bastide, Eric Lechevallier
No abstract text is available yet for this article.
February 23, 2023: BJU International
https://read.qxmd.com/read/36815233/teaching-robotic-cystectomy-prospective-pilot-clinical-validation-of-the-erus-training-curriculum
#17
JOURNAL ARTICLE
Romain Diamand, Frederiek D'Hondt, Georges Mjaess, Teddy Jabbour, Paolo Dell'Oglio, Alessandro Larcher, Marco Moschini, Thierry Quackels, Alexandre Peltier, Gregoire Assenmacher, Peter Wiklund, Alberto Breda, Filippo Turri, Ruben De Groote, Alexandre Mottrie, Thierry Roumeguere, Simone Albisinni
OBJECTIVE: To provide the first clinical validation of the EAU Robotic Urology Section (ERUS) curriculum for Robotic-Assisted Radical Cystectomy with intracorporeal urinary diversion (iRARC) training. The ERUS proposed a structured curriculum, divided in 11steps, to train novice surgeons and help overcome the steep learning curve of iRARC. No pilot clinical validation is available to date. PATIENTS AND METHODS: One trainee completed the curriculum under the mentorship of an expert...
February 22, 2023: BJU International
https://read.qxmd.com/read/36815226/oral-mucosal-graft-ureteroplasty-versus-ileal-ureteric-replacement-a-meta-analysis
#18
REVIEW
Yongqiang You, Xincheng Gao, Shuaishuai Chai, Jiawei Chen, Jianli Wang, Hao Zhang, Yuancheng Zhou, Zehao Yu, Gong Cheng, Bing Li, Xingyuan Xiao
OBJECTIVES: To describe outcomes of oral mucosal graft ureteroplasty (OMGU) and ileal ureter replacement (IUR) and determine the relative merits of both procedures. METHODS: Databases (including PubMed, Embase and Cochrane) were interrogated for eligible trials that assessed outcomes of OMGU or IUR from 2000 to 30 July 2022. The variables analysed were reconstruction success rates, stricture length, hospital stays, perioperative complications and long-term complications...
February 22, 2023: BJU International
https://read.qxmd.com/read/36797809/urine-supernatant-reveals-a-signature-that-predicts-survival-in-clear-cell-renal-cell-carcinoma
#19
JOURNAL ARTICLE
Jorge Daza, Bérengère Salomé, Kennedy E Okhawere, Octavia Bane, Kirolos N Meilika, Talia G Korn, Jingjing Qi, Hui Xe, Manishkumar Patel, Rachel Brody, Seunghee Kim-Schultz, John P Sfakianos, Sara Lewis, Jordan M Rich, Laura Zuluaga, Ketan K Badani, Amir Horowitz
OBJECTIVE: To profile cell-free urine supernatant and plasma of a small cohort of ccRCC patients by measuring the relative concentrations of 92 proteins related to inflammation. Using The Cancer Genome Atlas (TCGA), we then performed a targeted mRNA analysis of genes encoding the above proteins and defined their effects on overall survival (OS). SUBJECTS/PATIENTS AND METHODS: Samples were collected prospectively from ccRCC patients. A multiplex proximity extension assay was used to measure the concentrations of 92 inflammation-related proteins in cell-free urine supernatants and plasma...
February 16, 2023: BJU International
https://read.qxmd.com/read/36797449/lunar-a-randomized-phase-2-study-of-177-lutetium-psma-neoadjuvant-to-ablative-radiotherapy-for-oligorecurrent-prostate-cancer-clinical-trial-protocol
#20
JOURNAL ARTICLE
Ting Martin Ma, Johannes Czernin, Carol Felix, Rejah Alano, Holly Wilhalme, Luca Valle, Michael L Steinberg, Magnus Dahlbom, Robert E Reiter, Matthew B Rettig, Minsong Cao, Jeremie Calais, Amar U Kishan
OBJECTIVE: To assess the efficacy of 177 Lu-PNT2002, a novel radiolabelled small molecule that binds with high affinity to prostate-specific membrane antigen (PSMA), in combination with stereotactic body radiotherapy (SBRT) to all sites of metastasis, vs SBRT alone, in men with oligorecurrent metastatic hormone-sensitive prostate cancer (mHSPC). PATIENTS AND METHODS: The 177 Lutetium-PSMA Neoadjuvant to Ablative Radiotherapy for Oligorecurrent Prostate Cancer (LUNAR) trial is an open-label, randomized, stratified, two-arm, single-centre, Phase 2 trial to compare the efficacy and safety of neoadjuvant 177 Lu-PNT2002 plus SBRT vs SBRT alone in men with oligorecurrent mHSPC...
February 16, 2023: BJU International
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