Arthritis and Rheumatism

Chad L Deal
No abstract text is available yet for this article.
December 2013: Arthritis and Rheumatism
John D FitzGerald, Michael Battistone, Calvin R Brown, Amy C Cannella, Eliza Chakravarty, Allan C Gelber, Carlos J Lozada, Marilynn Punaro, Barbara Slusher, Abby Abelson, David A Elashoff, LaTanya Benford
OBJECTIVE: To analyze the distribution of rheumatology practices in the US and factors associated with that distribution, in order to better understand the supply of the rheumatology workforce. METHODS: Using the American College of Rheumatology membership database, all practicing adult rheumatologist office addresses were mapped with ArcView software. The number of rheumatologists per Core Based Statistical Area (CBSA) was calculated. To investigate whether sociodemographic factors correlated with clustering of rheumatologists, covariates from the 2010 US Census for each CBSA, including age, sex, race/ethnicity, and median household income, were modeled...
December 2013: Arthritis and Rheumatism
Benjamin Wilde, Sebastian Dolff, Oliver Witzke, Jan Damoiseaux, Jan Willem Cohen Tervaert
No abstract text is available yet for this article.
December 2013: Arthritis and Rheumatism
Meghan E Free, Maureen A Su
No abstract text is available yet for this article.
December 2013: Arthritis and Rheumatism
Youn-Kwan Jung, Gun-Woo Kim, Hye-Ri Park, Eun-Ju Lee, Je-Yong Choi, Frank Beier, Seung-Woo Han
OBJECTIVE: Interleukin-10 (IL-10) is a pleiotropic immunoregulatory cytokine with a chondroprotective effect that is elevated in cartilage and synovium in patients with osteoarthritis. However, the role of IL-10 during endochondral bone formation and its mechanism of action have not been elucidated. METHODS: IL-10(-/-) mice and IL-10-treated tibial organ cultures were used to study loss and gain of IL-10 functions, respectively, during endochondral bone formation...
December 2013: Arthritis and Rheumatism
Sree Rayavarapu, William Coley, Jack H Van der Meulen, Erdinc Cakir, Kathyayini Tappeta, Travis B Kinder, Blythe C Dillingham, Kristy J Brown, Yetrib Hathout, Kanneboyina Nagaraju
OBJECTIVE: Myositis is characterized by severe muscle weakness. We and others have previously shown that endoplasmic reticulum (ER) stress plays a role in the pathogenesis of myositis. The present study was undertaken to identify perturbed pathways and assess their contribution to muscle disease in a mouse myositis model. METHODS: Stable isotope labeling with amino acids in cell culture (SILAC) was used to identify alterations in the skeletal muscle proteome of myositic mice in vivo...
December 2013: Arthritis and Rheumatism
Christian G Ammitzbøll, Steffen Thiel, Jens C Jensenius, Torkell Ellingsen, Kim Hørslev-Petersen, Merete L Hetland, Peter Junker, Niels S Krogh, Mikkel Østergaard, Kristian Stengaard-Pedersen
OBJECTIVE: To assess plasma M-ficolin concentrations in disease-modifying antirheumatic drug (DMARD)-naive patients with early rheumatoid arthritis (RA), to investigate the correlation of M-ficolin concentrations with disease activity markers, and to determine the predictive value of M-ficolin with respect to the Disease Activity Score in 28 joints (DAS28). METHODS: The study group included 180 DMARD-naive patients with early RA who participated in a randomized controlled trial of methotrexate and intraarticular glucocorticoids plus either adalimumab or placebo/adalimumab...
December 2013: Arthritis and Rheumatism
Chad M Brummett, Jenna Goesling, Alex Tsodikov, Taha S Meraj, Ronald A Wasserman, Daniel J Clauw, Afton L Hassett
OBJECTIVE: Injections for spinal pain have high failure rates, emphasizing the importance of patient selection. It is possible that detecting the presence of a fibromyalgia (FM)-like phenotype could aid in prediction, because in these individuals a peripheral injection would not address pain due to alterations in central neurotransmission. We undertook this study to test the hypothesis that patients who have spine pain meeting survey criteria for FM would be phenotypically distinct from those who do not...
December 2013: Arthritis and Rheumatism
Stephanie G Werner, Hans-Eckhard Langer, Peter Schott, Malte Bahner, Carsten Schwenke, Gudrun Lind-Albrecht, Felicitas Spiecker, Bernward Kurtz, Gerd R Burmester, Marina Backhaus
OBJECTIVE: Indocyanine green-enhanced fluorescence optical imaging (FOI) is a novel diagnostic tool for the assessment of inflammation in arthritis. We undertook this study to compare FOI with magnetic resonance imaging (MRI) in 32 patients with early and very early untreated arthritis (mean disease duration 7.1 months). METHODS: FOI images were acquired with the commercially available Xiralite system. Image interpretation was done for an early phase (phase 1), an intermediate phase (phase 2), and a late phase (phase 3), and for an electronically generated composite image...
December 2013: Arthritis and Rheumatism
Jijun Zhao, Hongyue Wang, Chao Dai, Hongyang Wang, Hui Zhang, Yuefang Huang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu
OBJECTIVE: The NLRP3 inflammasome plays key roles in inflammation and autoimmunity, and purinergic receptor P2X7 has been proposed to be upstream of NLRP3 activation. The aim of the present study, using murine models, was to investigate whether the P2X7 /NLRP3 inflammasome pathway contributes to the pathogenesis of lupus nephritis (LN). METHODS: MRL/lpr mice were treated with the selective P2X7 antagonist brilliant blue G (BBG) for 8 weeks. Following treatment, the severity of renal lesions, production of anti-double-stranded DNA (anti-dsDNA) antibodies, rate of survival, activation of the NLRP3/ASC/caspase 1 inflammasome pathway, and ratio of Th17 cells to Treg cells were evaluated...
December 2013: Arthritis and Rheumatism
Shio Kobayashi, Koichi Murata, Hideyuki Shibuya, Mami Morita, Masahiro Ishikawa, Moritoshi Furu, Hiromu Ito, Juichi Ito, Shuichi Matsuda, Takeshi Watanabe, Hiroyuki Yoshitomi
OBJECTIVE: A subset of CD4+ T cells in the synovium of patients with rheumatoid arthritis (RA) produce CXCL13, a chemokine that is crucial for the formation of germinal centers. This study was undertaken to determine the relevance of this population to known subsets of T helper cells and to proinflammatory cytokines, and how these cells are generated. METHODS: The expression of Th markers and CXCL13 by CD4+ T cells in RA synovium and the involvement of proinflammatory cytokines in CXCL13 production were assessed...
December 2013: Arthritis and Rheumatism
Dinesh Khanna, Heather Gladue, Richard Channick, Lorinda Chung, Oliver Distler, Daniel E Furst, Eric Hachulla, Marc Humbert, David Langleben, Stephen C Mathai, Rajeev Saggar, Scott Visovatti, Nezam Altorok, Whitney Townsend, John FitzGerald, Vallerie V McLaughlin
OBJECTIVE: Pulmonary arterial hypertension (PAH) affects up to 15% of patients with connective tissue diseases (CTDs). Previous recommendations developed as part of larger efforts in PAH did not include detailed recommendations for patients with CTD-associated PAH. Therefore, we sought to develop recommendations for screening and early detection of CTD-associated PAH. METHODS: We performed a systematic review of the literature on the screening and diagnosis of PAH in CTD...
December 2013: Arthritis and Rheumatism
Su Jin Park, Eun Jeong Cheon, Mi Hyun Lee, Hyun Ah Kim
OBJECTIVE: MicroRNAs (miRNAs), small noncoding RNA molecules, are involved in the pathogenesis of various diseases such as cancer and arthritis. The aim of this study was to determine whether miR-127-5p regulates interleukin-1β (IL-1β)-induced expression of matrix metalloproteinase 13 (MMP-13) and other catabolic factors in human chondrocytes. METHODS: Expression of miR-127-5p and MMP-13 by normal and osteoarthritic (OA) human cartilage was determined using real-time polymerase chain reaction...
December 2013: Arthritis and Rheumatism
Tao Xu, Cheng Huang, Jun Li, Yangyang Li, Ziyu Deng
No abstract text is available yet for this article.
December 2013: Arthritis and Rheumatism
Shahla Abdollahi-Roodsaz, Marije I Koenders, Peter L van Lent, Wim B van den Berg
No abstract text is available yet for this article.
December 2013: Arthritis and Rheumatism
Nicholas A Young, Rahul Sharma, Alexandra K Friedman, Benjamin H Kaffenberger, Brad Bolon, Wael N Jarjour
OBJECTIVE: Myositis is associated with muscle-targeted inflammation and is observed in some Treg cell-deficient mouse models. Because an autoimmune pathogenesis has been strongly implicated, the aim of this study was to investigate the hypothesis that abnormal exposure to muscle antigens, as observed in muscle injury, can induce autoimmune-mediated myositis in susceptible hosts. METHODS: FoxP3 mutant (scurfy) mice were mated to synaptotagmin VII (Syt VII) mutant mice, which resulted in a new mouse strain that combines impaired membrane resealing with Treg cell deficiency...
December 2013: Arthritis and Rheumatism
Kate McAllister, Annie Yarwood, John Bowes, Gisela Orozco, Sebastian Viatte, Dorothée Diogo, Lynne J Hocking, Sophia Steer, Paul Wordsworth, A G Wilson, Ann W Morgan, Joel M Kremer, Dimitrios Pappas, Peter Gregersen, Lars Klareskog, Robert Plenge, Anne Barton, Jeffrey Greenberg, Jane Worthington, Stephen Eyre
OBJECTIVE: A recent high-density fine-mapping (ImmunoChip) study of genetic associations in rheumatoid arthritis (RA) identified 14 risk loci with validated genome-wide significance, as well as a number of loci showing associations suggestive of significance (P = 5 × 10(-5) < 5 × 10(-8)), but these have yet to be replicated. The aim of this study was to determine whether these potentially significant loci are involved in the pathogenesis of RA, and to explore whether any of the loci are associated with a specific RA serotype...
December 2013: Arthritis and Rheumatism
Kirk A Campbell, Takeshi Minashima, Ying Zhang, Scott Hadley, You Jin Lee, Joseph Giovinazzo, Martin Quirno, Thorsten Kirsch
OBJECTIVE: ANXA6, the gene for annexin A6, is highly expressed in osteoarthritic (OA) articular chondrocytes but not in healthy articular chondrocytes. This study was undertaken to determine whether annexin A6 affects catabolic events in these cells. METHODS: Articular chondrocytes were isolated from Anxa6-knockout mice, wild-type (WT) mice, and human articular cartilage in which ANXA6 was overexpressed. Cells were treated with interleukin-1β (IL-1β) or tumor necrosis factor α (TNFα), and expression of catabolic genes and activation of NF-κB were determined by real-time polymerase chain reaction and luciferase reporter assay...
December 2013: Arthritis and Rheumatism
A Krabben, A G Wilson, D P C de Rooy, A Zhernakova, E Brouwer, E Lindqvist, T Saxne, G Stoeken, J A B van Nies, R Knevel, T W J Huizinga, R Toes, P K Gregersen, A H M van der Helm-van Mil
OBJECTIVE: The progression of joint destruction in rheumatoid arthritis (RA) is determined by genetic factors. Changes in IL4 and IL4R genes have been associated with RA severity, but this finding has not been replicated. This study was undertaken to investigate the association between IL4- and IL4R-tagging single-nucleotide polymorphisms (SNPs) and the progression rate of joint damage in RA in a multicohort candidate gene study. METHODS: IL4- and IL4R-tagging SNPs (n = 8 and 39, respectively) were genotyped in 600 RA patients for whom 2,846 sets of radiographs of the hands and feet were obtained during 7 years of followup...
December 2013: Arthritis and Rheumatism
Adrian Ciurea, Almut Scherer, Pascale Exer, Jürg Bernhard, Jean Dudler, Brigitte Beyeler, Rudolf Kissling, Daniel Stekhoven, Kaspar Rufibach, Giorgio Tamborrini, Bettina Weiss, Rüdiger Müller, Michael J Nissen, Beat A Michel, Désirée van der Heijde, Maxime Dougados, Annelies Boonen, Ulrich Weber
OBJECTIVE: To evaluate the baseline characteristics of patients with radiographic axial spondyloarthritis (SpA; ankylosing spondylitis [AS]) and patients with nonradiographic axial SpA, to investigate determinants of anti-tumor necrosis factor (anti-TNF) agent prescription on the background of a nonrestrictive reimbursement policy, and to assess the response to TNF inhibition. METHODS: We compared the characteristics of radiographic axial SpA and nonradiographic axial SpA in 1,070 patients from the Swiss Clinical Quality Management (SCQM) Cohort who fulfilled the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial SpA...
December 2013: Arthritis and Rheumatism
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