Kate McAllister, Annie Yarwood, John Bowes, Gisela Orozco, Sebastian Viatte, Dorothée Diogo, Lynne J Hocking, Sophia Steer, Paul Wordsworth, A G Wilson, Ann W Morgan, Joel M Kremer, Dimitrios Pappas, Peter Gregersen, Lars Klareskog, Robert Plenge, Anne Barton, Jeffrey Greenberg, Jane Worthington, Stephen Eyre
OBJECTIVE: A recent high-density fine-mapping (ImmunoChip) study of genetic associations in rheumatoid arthritis (RA) identified 14 risk loci with validated genome-wide significance, as well as a number of loci showing associations suggestive of significance (P = 5 × 10(-5) < 5 × 10(-8)), but these have yet to be replicated. The aim of this study was to determine whether these potentially significant loci are involved in the pathogenesis of RA, and to explore whether any of the loci are associated with a specific RA serotype...
December 2013: Arthritis and Rheumatism