journal
Journals Arteriosclerosis, Thrombosis, ...

Arteriosclerosis, Thrombosis, and Vascular Biology

https://read.qxmd.com/read/38841857/molecular-changes-implicate-angiogenesis-and-arterial-remodeling-in-systemic-sclerosis-associated-and-idiopathic-pulmonary-hypertension
#21
JOURNAL ARTICLE
Yuechen Zhou, Tracy Tabib, Mengqi Huang, Ke Yuan, Yunhye Kim, Christina Morse, John Sembrat, Eleanor Valenzi, Robert Lafyatis
BACKGROUND: Pulmonary hypertension (PH) is a common complication of systemic sclerosis (SSc) and a leading cause of mortality among patients with this disease. PH can also occur as an idiopathic condition (idiopathic pulmonary arterial hypertension). Investigation of transcriptomic alterations in vascular populations is critical to elucidating cellular mechanisms underlying pathobiology of SSc-associated and idiopathic PH. METHODS: We analyzed single-cell RNA sequencing profiles of endothelial and perivascular mesenchymal populations from explanted lung tissue of patients with SSc-associated PH (n=16), idiopathic pulmonary arterial hypertension (n=3), and healthy controls (n=15)...
June 6, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38813700/t-cell-b-cell-interactions-in-atherosclerosis
#22
REVIEW
Peter William Jones, Ziad Mallat, Meritxell Nus
Atherosclerosis is a complex inflammatory disease in which the adaptive immune response plays an important role. While the overall impact of T and B cells in atherosclerosis is relatively well established, we are only beginning to understand how bidirectional T-cell/B-cell interactions can exert prominent atheroprotective and proatherogenic functions. In this review, we will focus on these T-cell/B-cell interactions and how we could use them to therapeutically target the adaptive immune response in atherosclerosis...
May 30, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38813699/therapeutic-avenues-to-modulate-b-cell-function-in-patients-with-cardiovascular-disease
#23
REVIEW
James W O'Brien, Ayden Case, Claudia Kemper, Tian X Zhao, Ziad Mallat
The adaptive immune system plays an important role in the development and progression of atherosclerotic cardiovascular disease. B cells can have both proatherogenic and atheroprotective roles, making treatments aimed at modulating B cells important therapeutic targets. The innate-like B-cell response is generally considered atheroprotective, while the adaptive response is associated with mixed consequences for atherosclerosis. Additionally, interactions of B cells with components of the adaptive and innate immune system, including T cells and complement, also represent key points for therapeutic regulation...
May 30, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38813698/blocking-interleukin-1%C3%AE-a-double-edged-sword-in-experimental-atherosclerosis
#24
EDITORIAL
Neil MacRitchie, Pasquale Maffia
No abstract text is available yet for this article.
May 30, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38813697/plasma-proteomics-identifies-b2m-as-a-regulator-of-pulmonary-hypertension-in-heart-failure-with-preserved-ejection-fraction
#25
JOURNAL ARTICLE
Jia-Rong Jheng, Jacqueline T DesJardin, Yi-Yun Chen, Joshua R Huot, Yang Bai, Todd Cook, Lainey M Hibbard, Jennifer M Rupp, Amanda Fisher, Yingze Zhang, Julio D Duarte, Ankit A Desai, Roberto F Machado, Marc A Simon, Yen-Chun Lai
BACKGROUND: Pulmonary hypertension (PH) represents an important phenotype in heart failure with preserved ejection fraction (HFpEF). However, management of PH-HFpEF is challenging because mechanisms involved in the regulation of PH-HFpEF remain unclear. METHODS: We used a mass spectrometry-based comparative plasma proteomics approach as a sensitive and comprehensive hypothesis-generating discovery technique to profile proteins in patients with PH-HFpEF and control subjects...
May 30, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38779856/%C3%AE-aminopropionitrile-induces-distinct-pathologies-in-the-ascending-and-descending-thoracic-aortic-regions-of-mice
#26
JOURNAL ARTICLE
Michael K Franklin, Hisashi Sawada, Sohei Ito, Deborah A Howatt, Naofumi Amioka, Ching-Ling Liang, Nancy Zhang, David B Graf, Jessica J Moorleghen, Yuriko Katsumata, Hong S Lu, Alan Daugherty
BACKGROUND: β-aminopropionitrile (BAPN) is a pharmacological inhibitor of LOX (lysyl oxidase) and LOXLs (LOX-like proteins). Administration of BAPN promotes aortopathies, although there is a paucity of data on experimental conditions to generate pathology. The objective of this study was to define experimental parameters and determine whether equivalent or variable aortopathies were generated throughout the aortic tree during BAPN administration in mice. METHODS: BAPN was administered in drinking water for a period ranging from 1 to 12 weeks...
May 23, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38779855/3dvascnet-an-automated-software-for-segmentation-and-quantification-of-mouse-vascular-networks-in-3d
#27
JOURNAL ARTICLE
Hemaxi Narotamo, Margarida Silveira, Cláudio A Franco
BACKGROUND: Analysis of vascular networks is an essential step to unravel the mechanisms regulating the physiological and pathological organization of blood vessels. So far, most of the analyses are performed using 2-dimensional projections of 3-dimensional (3D) networks, a strategy that has several obvious shortcomings. For instance, it does not capture the true geometry of the vasculature and generates artifacts on vessel connectivity. These limitations are accepted in the field because manual analysis of 3D vascular networks is a laborious and complex process that is often prohibitive for large volumes...
May 23, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38779854/influence-of-polygenic-background-on-the-clinical-presentation-of-familial-hypercholesterolemia
#28
JOURNAL ARTICLE
Mark Trinder, Lubomira Cermakova, Isabelle Ruel, Alexis Baass, Martine Paquette, Jian Wang, Brooke A Kennedy, Robert A Hegele, Jacques Genest, Liam R Brunham
BACKGROUND: Heterozygous familial hypercholesterolemia (FH) is among the most common genetic conditions worldwide that affects ≈ 1 in 300 individuals. FH is characterized by increased levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of coronary artery disease (CAD), but there is a wide spectrum of severity within the FH population. This variability in expression is incompletely explained by known risk factors. We hypothesized that genome-wide genetic influences, as represented by polygenic risk scores (PRSs) for cardiometabolic traits, would influence the phenotypic severity of FH...
May 23, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38779853/cancer-incidence-after-diagnosis-of-abdominal-aortic-aneurysm
#29
JOURNAL ARTICLE
Lingfeng Luo, Allen M Haas, Caitlin F Bell, Richard A Baylis, Shaunak S Adkar, Changhao Fu, Ivan Angelov, Sharon H Giordano, Derek Klarin, Nicholas J Leeper, Kevin T Nead
BACKGROUND: Epidemiological and mechanistic data support a potential causal link between cardiovascular disease (CVD) and cancer. Abdominal aortic aneurysms (AAAs) represent a common form of CVD with at least partially distinct genetic and biologic etiology from other forms of CVD. The risk of cancer and how this risk differs compared with other forms of CVD, is unknown among AAA patients. We conducted a retrospective cohort study using the IBM MarketScan Research Database to test whether individuals with AAA have a higher cancer risk independent of traditional shared risk factors...
May 23, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38752350/de-novo-elastin-assembly-alleviates-development-of-supravalvular-aortic-stenosis
#30
JOURNAL ARTICLE
Matthew W Ellis, Muhammad Riaz, Yan Huang, Christopher W Anderson, Marie Hoareau, Xin Li, Hangqi Luo, Seoyeon Lee, Jinkyu Park, Jiesi Luo, Luke D Batty, Qunhua Huang, Colleen A Lopez, Dieter P Reinhardt, George Tellides, Yibing Qyang
BACKGROUND: A series of incurable cardiovascular disorders arise due to improper formation of elastin during development. Supravalvular aortic stenosis (SVAS), resulting from a haploinsufficiency of ELN , is caused by improper stress sensing by medial vascular smooth muscle cells, leading to progressive luminal occlusion and heart failure. SVAS remains incurable, as current therapies do not address the root issue of defective elastin. METHODS: We use SVAS here as a model of vascular proliferative disease using both human induced pluripotent stem cell-derived vascular smooth muscle cells and developmental Eln ± mouse models to establish de novo elastin assembly as a new therapeutic intervention...
May 16, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38752349/histidine-rich-glycoprotein-modulates-the-toxic-effects-of-high-dose-polyphosphate-in-mice
#31
JOURNAL ARTICLE
Rida A Malik, Ji Zhou, James C Fredenburgh, Jeff Crosby, Alexey S Revenko, Jeff S Healey, Jeffrey I Weitz
BACKGROUND: Polyphosphate (polyP), a procoagulant released from platelets, activates coagulation via the contact system and modulates cardiomyocyte viability. High-dose intravenous polyP is lethal in mice, presumably because of thrombosis. Previously, we showed that HRG (histidine-rich glycoprotein) binds polyP and attenuates its procoagulant effects. In this study, we investigated the mechanisms responsible for the lethality of intravenous polyP in mice and the impact of HRG on this process...
May 16, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38752348/association-of-aortic-stiffness-and-pressure-pulsatility-with-noninvasive-estimates-of-hepatic-steatosis-and-fibrosis-the-framingham-heart-study
#32
JOURNAL ARTICLE
Leroy L Cooper, Brenton R Prescott, Vanessa Xanthakis, Emelia J Benjamin, Ramachandran S Vasan, Naomi M Hamburg, Michelle T Long, Gary F Mitchell
BACKGROUND: Arterial stiffening may contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease. We aimed to assess relations of vascular hemodynamic measures with measures of hepatic steatosis and fibrosis in the community. METHODS: Our sample was drawn from the Framingham Offspring, New Offspring Spouse, Third Generation, Omni-1, and Omni-2 cohorts (N=3875; mean age, 56 years; 54% women). We used vibration-controlled transient elastography to assess controlled attenuation parameter and liver stiffness measurements as measures of liver steatosis and liver fibrosis, respectively...
May 16, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38721708/changes-in-ocular-perfusion-and-pressure-changes-in-gravitational-alteration-contribute-to-spaceflight-associated-neuro-ocular-syndrome
#33
LETTER
Stephan Binneboessel, Norbert Gerdes, Michael Baertschi, Sema Kaya, Gerd Geerling, Malte Kelm, Christian Jung
No abstract text is available yet for this article.
May 9, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38721707/plaque-ruptures-are-related-to-high-plaque-stress-and-strain-conditions-direct-verification-by-using-in-vivo-oct-rupture-data-and-fsi-models
#34
JOURNAL ARTICLE
Chen Zhao, Rui Lv, Akiko Maehara, Liang Wang, Zhanqun Gao, Yishuo Xu, Xiaoya Guo, Yanwen Zhu, Mengde Huang, Xiaoguo Zhang, Jian Zhu, Bo Yu, Haibo Jia, Gary S Mintz, Dalin Tang
BACKGROUND: While it has been hypothesized that high plaque stress and strain may be related to plaque rupture, its direct verification using in vivo coronary plaque rupture data and full 3-dimensional fluid-structure interaction models is lacking in the current literature due to difficulty in obtaining in vivo plaque rupture imaging data from patients with acute coronary syndrome. This case-control study aims to use high-resolution optical coherence tomography-verified in vivo plaque rupture data and 3-dimensional fluid-structure interaction models to seek direct evidence for the high plaque stress/strain hypothesis...
May 9, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38695172/trem2-agonist-reprograms-foamy-macrophages-to-promote-atherosclerotic-plaque-stability
#35
JOURNAL ARTICLE
Michael T Patterson, Yingzheng Xu, Hannah Hillman, Victoria Osinski, Patricia R Schrank, Ainsley E Kennedy, Fanta Barrow, Alisha Zhu, Samuel Tollison, Sia Shekhar, Ingunn M Stromnes, Ilaria Tassi, Dick Wu, Xavier S Revelo, Bryce A Binstadt, Jesse W Williams
OBJECTIVE: Trem2 (triggering receptor on myeloid cells 2), a surface lipid receptor, is expressed on foamy macrophages within atherosclerotic lesions and regulates cell survival, proliferation, and anti-inflammatory responses. Studies examining the role of Trem2 in atherosclerosis have shown that deletion of Trem2 leads to impaired foamy macrophage lipid uptake, proliferation, survival, and cholesterol efflux. Thus, we tested the hypothesis that administration of a Trem2 agonist antibody (AL002a) to atherogenic mice would enhance macrophage survival and decrease necrotic core formation to improve plaque stability...
May 2, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38695171/use-of-ipsc-derived-smooth-muscle-cells-to-model-physiology-and-pathology
#36
REVIEW
Callie S Kwartler, Jose Emiliano Esparza Pinelo
The implementation of human-induced pluripotent stem cell models has introduced an additional tool for identifying molecular mechanisms of disease that complement animal models. Patient-derived or CRISPR/Cas9-edited induced pluripotent stem cells differentiated into smooth muscle cells (SMCs) have been leveraged to discover novel mechanisms, screen potential therapeutic strategies, and model in vivo development. The field has evolved over almost 15 years of research using human-induced pluripotent stem cell-SMCs and has made significant strides toward overcoming initial challenges such as the lineage specificity of SMC phenotypes...
May 2, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38695170/macrophage-derived-gsdmd-plays-an-essential-role-in-atherosclerosis-and-cross-talk-between-macrophages-via-the-mitochondria-sting-irf3-nf-%C3%AE%C2%BAb-axis
#37
JOURNAL ARTICLE
Xiaoxi Fan, Jibo Han, Lingfeng Zhong, Wenyuan Zheng, Ruiyin Shao, Yucong Zhang, Si Shi, Shuang Lin, Zhouqing Huang, Weijian Huang, Xueli Cai, Bozhi Ye
BACKGROUND: Macrophages play a crucial role in atherosclerotic plaque formation, and the death of macrophages is a vital factor in determining the fate of atherosclerosis. GSDMD (gasdermin D)-mediated pyroptosis is a programmed cell death, characterized by membrane pore formation and inflammatory factor release. METHODS: ApoE -/- and Gsdmd -/- ApoE -/- mice, bone marrow transplantation, and AAV-F4/80-shGSDMD were used to examine the effect of macrophage-derived GSDMD on atherosclerosis...
May 2, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38695168/effects-of-recombinant-human-lecithin-cholesterol-acyltransferase-on-lipoprotein-metabolism-in-humans
#38
JOURNAL ARTICLE
Gissette Reyes-Soffer, Anastasiya Matveyenko, James Lignos, Nelsa Matienzo, Leinys S Santos Baez, Antonio Hernandez-One, Lau Yung, Renu Nandakumar, Sasha A Singh, Masanori Aikawa, Richard George, Henry N Ginsberg
BACKGROUND: LCAT (lecithin cholesterol acyl transferase) catalyzes the conversion of unesterified, or free cholesterol, to cholesteryl ester, which moves from the surface of HDL (high-density lipoprotein) into the neutral lipid core. As this iterative process continues, nascent lipid-poor HDL is converted to a series of larger, spherical cholesteryl ester-enriched HDL particles that can be cleared by the liver in a process that has been termed reverse cholesterol transport. METHODS: We conducted a randomized, placebocontrolled, crossover study in 5 volunteers with atherosclerotic cardiovascular disease, to examine the effects of an acute increase of recombinant human (rh) LCAT via intravenous administration (300-mg loading dose followed by 150 mg at 48 hours) on the in vivo metabolism of HDL APO (apolipoprotein)A1 and APOA2, and the APOB100-lipoproteins, very low density, intermediate density, and low-density lipoproteins...
May 2, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38695167/il-1%C3%AE-inhibition-partially-negates-the-beneficial-effects-of-diet-induced-atherosclerosis-regression-in-mice
#39
JOURNAL ARTICLE
Santosh Karnewar, Vaishnavi Karnewar, Rebecca Deaton, Laura S Shankman, Ernest D Benavente, Corey M Williams, Xenia Bradley, Gabriel F Alencar, Gamze B Bulut, Sara Kirmani, Richard A Baylis, Eli R Zunder, Hester M den Ruijter, Gerard Pasterkamp, Gary K Owens
BACKGROUND: Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions is the global leading cause of death. The most common and effective means to reduce these major adverse cardiovascular events, including myocardial infarction and stroke, is aggressive lipid lowering via a combination of drugs and dietary modifications. However, we know little regarding the effects of reducing dietary lipids on the composition and stability of advanced atherosclerotic lesions, the mechanisms that regulate these processes, and what therapeutic approaches might augment the benefits of lipid lowering...
May 2, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38660806/immunoproteasomal-inhibition-with-onx-0914-attenuates-atherosclerosis-and-reduces-white-adipose-tissue-mass-and-metabolic-syndrome-in-mice
#40
JOURNAL ARTICLE
Frank H Schaftenaar, Andrea D van Dam, Gerjan de Bruin, Marie A C Depuydt, Jill de Mol, Jacob Amersfoort, Hidde Douna, Menno Meijer, Mara J Kröner, Peter J van Santbrink, Mireia N A Bernabé Kleijn, Gijs H M van Puijvelde, Bogdan I Florea, Bram Slütter, Amanda C Foks, Ilze Bot, Patrick C N Rensen, Johan Kuiper
BACKGROUND: Atherosclerosis is the major underlying pathology of cardiovascular disease and is driven by dyslipidemia and inflammation. Inhibition of the immunoproteasome, a proteasome variant that is predominantly expressed by immune cells and plays an important role in antigen presentation, has been shown to have immunosuppressive effects. METHODS: We assessed the effect of ONX-0914, an inhibitor of the immunoproteasomal catalytic subunits LMP7 (proteasome subunit β5i/large multifunctional peptidase 7) and LMP2 (proteasome subunit β1i/large multifunctional peptidase 2), on atherosclerosis and metabolism in LDLr-/- and APOE*3-Leiden...
April 25, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
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