Archives of Disease in Childhood

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March 27, 2020: Archives of Disease in Childhood
Michael Andrew Colvin, Leanne Brennan, Kirsty Hogg, Helen Taylor, Kathleen Skinner
No abstract text is available yet for this article.
March 27, 2020: Archives of Disease in Childhood
Emily Andrews, Amitava Sur
No abstract text is available yet for this article.
March 26, 2020: Archives of Disease in Childhood
Roona Aniapravan, Colin Powell
No abstract text is available yet for this article.
March 26, 2020: Archives of Disease in Childhood
Paula Heikkilä, Matti Korppi
No abstract text is available yet for this article.
March 25, 2020: Archives of Disease in Childhood
Stuart Haggie, Hasantha Gunasekera, Chetan Pandit, Hiran Selvadurai, Paul Robinson, Dominic A Fitzgerald
OBJECTIVE: Empyema is the most common complication of pneumonia. Primary interventions include chest drainage and fibrinolytic therapy (CDF) or video-assisted thoracoscopic surgery (VATS). We describe disease trends, clinical outcomes and factors associated with reintervention. DESIGN/SETTING/PATIENTS: Retrospective cohort of paediatric empyema cases requiring drainage or surgical intervention, 2011-2018, admitted to a large Australian tertiary children's hospital...
March 24, 2020: Archives of Disease in Childhood
Winnie Chan, Pravheen Thurairajah, Nancy Butcher, Cor Oosterwijk, Kim Wever, Irmgard Eichler, Charles Thompson, Anne Junker, Martin Offringa, Jennifer Preston
BACKGROUND: Engaging patients and the public as collaborators in research is increasingly recognised as important as such partnerships can help improve research relevance and acceptability. Young Persons' Advisory Groups (YPAGs) provide a forum for clinical researchers and triallists to engage with children and young people on issues relevant to the design, conduct and translation of paediatric clinical trials. Until fairly recently, there was very little information available to guide the successful development and operation of YPAGs...
March 24, 2020: Archives of Disease in Childhood
Laura Ferreras-Antolín, Godwin Oligbu, Ifeanyichukwu O Okike, Shamez Ladhani
OBJECTIVE: To estimate the contribution of infections to childhood deaths in England and Wales over a 3-year period. DESIGN: Retrospective analysis of national electronic death registration data. SETTING: England and Wales. PATIENTS: Children aged 28 days to 15 years who died during 2013-15. MAIN OUTCOME MEASURES: The proportion of children who died of infection compared with total deaths over 3 years; the main pathogens responsible for infection-related deaths in different age groups; comparison with similar data from 2003 to 2005...
March 24, 2020: Archives of Disease in Childhood
Paul Dimitri, Kush Joshi, Natasha Jones
While the benefits of regular participation in physical activity in children and young people are clear, misconceptions have developed about the possible negative effects and potential complications of exercise on long-term conditions such as epilepsy, asthma and diabetes. Over the last decade evidence has emerged supporting the positive impact that physical activity has on long-term conditions. Previous concerns were raised about the risks of hypoglycaemia in children with type 1 diabetes mellitus (T1DM) thus limiting participation in sports...
March 20, 2020: Archives of Disease in Childhood
Gul Ambreen, Muhammad Sohail Salat, Kashif Hussain, Syed Shamim Raza, Umer Ali, Iqbal Azam, Junaid Iqbal, Zafar Fatmi
OBJECTIVE: Infections with multidrug-resistant organisms (MDROs) such as Gram-negative bacteria have high morbidity and mortality with limited treatment options. Colistin, an antibiotic active against MDRO, was rarely used due to frequent adverse effects, but its use has now been recommended among adults. In this study, we determined the efficacy of colistin for the treatment of sepsis in neonates. DESIGN/SETTING/PATIENTS/OUTCOMES: We conducted a retrospective record review of all neonates admitted to the neonatal intensive care unit of Aga Khan University Hospital, Karachi, Pakistan, between June 2015 and June 2018, who had sepsis and received colistin by intravenous, inhalation and/or intrathecal routes...
March 20, 2020: Archives of Disease in Childhood
Nicola Seneviratne, Daniel Yeomanson, Robert Phillips
BACKGROUND: Recent research in febrile neutropaenia (FN) has focused on reducing the intensity of treatment for those thought to be at low risk of significant morbidity or mortality. This has not led to a reduced burden of treatment for either families or healthcare systems. An alternative approach is to discharge all patients who remain well after 48 hours of inpatient treatment, either with no ongoing treatment or with appropriate antibiotics if the cultures are positive. This paper aimed to demonstrate that this approach is safe...
March 17, 2020: Archives of Disease in Childhood
Max Davie
No abstract text is available yet for this article.
March 13, 2020: Archives of Disease in Childhood
Amy E Peden, Stacey Willcox-Pidgeon
OBJECTIVES: This study explored unintentional fatal drowning among children and adolescents (0-19 years) diagnosed with autism spectrum disorder (ASD) in Australia. DESIGN: This total population, cross-sectional audit used data from the Royal Life Saving National Fatal Drowning Database to explore demographic and causal factors in ASD drowning cases between 1 July 2002 and 30 June 2018. Rates and relative risk (RR) with a 95% confidence interval (CI) were calculated for drowning cases with and without ASD, using estimated population-level prevalence data...
March 13, 2020: Archives of Disease in Childhood
Morris Ogero, Samuel Akech, Lucas Malla, Ambrose Agweyu, Grace Irimu, Mike English
BACKGROUND: We explored who actually provides most admission care in hospitals offering supervised experiential training to graduating clinicians in a high mortality setting where practices deviate from guideline recommendations. METHODS: We used a large observational data set from 13 Kenyan county hospitals from November 2015 through November 2018 where patients were linked to admitting clinicians. We explored guideline adherence after creating a cumulative correctness of Paediatric Admission Quality of Care (cPAQC) score on a 5-point scale (0-4) in which points represent correct, sequential progress in providing care perfectly adherent to guidelines comprising admission assessment, diagnosis and treatment...
March 12, 2020: Archives of Disease in Childhood
Aisling Mary Smith, Philip T Levy, Orla Franklin, Eleanor Molloy, Afif El-Khuffash
Down Syndrome (DS) is the most common chromosomal abnormality of live born babies. Individuals with DS are at increased risk of cardiopulmonary morbidities in the early neonatal period, infancy and childhood that manifest with elevated pulmonary arterial pressures and altered myocardial performance. Pulmonary hypertension (PH) during the early neonatal period remains under-recognised in this population. PH may occur with or without a congenital heart defect in children with DS and is more common than in the general population...
March 11, 2020: Archives of Disease in Childhood
André Ricardo Araujo da Silva, Amanda Marques, Clara Di Biase, Monique Faitanin, Indah Murni, Angela Dramowski, Johannes Hübner, Walter Zingg
INTRODUCTION: Antimicrobial stewardship programmes (ASPs) are recommended to improve antibiotic use in healthcare and reduce antimicrobial resistance (AMR). Our aim was to investigate the effectiveness of ASPs in reducing antibiotic consumption, use of broad-spectrum/restricted antibiotics, antibiotic resistance and healthcare-associated infections (HAIs) in neonates. METHODS: We searched PUBMED, SCIELO, EMBASE and the Cochrane Database (January 2000-April 2019) to identify studies on the effectiveness of ASPs in neonatal wards and/or neonatal intensive care units (NICUs)...
March 10, 2020: Archives of Disease in Childhood
Bruna Rubbo, Sunayna Best, Robert Anthony Hirst, Amelia Shoemark, Patricia Goggin, Siobhan B Carr, Philip Chetcuti, Claire Hogg, Priti Kenia, Jane S Lucas, Eduardo Moya, Manjith Narayanan, Christopher O'Callaghan, Michael Williamson, Woolf Theodore Walker
OBJECTIVE: In England, the National Health Service commissioned a National Management Service for children with primary ciliary dyskinesia (PCD). The aims of this study were to describe the health of children seen in this Service and compare lung function to children with cystic fibrosis (CF). DESIGN: Multi-centre service evaluation of the English National Management PCD Service. SETTING: Four nationally commissioned PCD centres in England...
March 10, 2020: Archives of Disease in Childhood
David Tappin, Mariusz Grzeda, Carol Joinson, Jon Heron
OBJECTIVES: To assess evidence supporting the view that 'low fibre causes childhood constipation'. DESIGN: Triangulation integrated three approaches: a systematic review NICE guideline CG99 examining effectiveness of increasing fibre; a cohort study, Avon Longitudinal Study of Parents and Children (ALSPAC), to assess if constipation (or hard stools) can precede fibre intake at weaning; and a literature search for twin studies to calculate heredity. SETTING: CG99 examined the literature regarding the effectiveness of increasing fibre...
March 10, 2020: Archives of Disease in Childhood
Edward Thomas Andrews, R Mark Beattie, Mark P Tighe
Abdominal pain in childhood is extremely common and presents frequently to both primary and secondary care, with many children having recurrent pain which impacts on daily functioning. Despite this most children have no discernible underlying pathology. We discuss the underlying mechanism for functional abdominal pain (visceral hypersensitivity), the evidence base linking parental anxiety and patient symptoms, and how parents can be supported in managing their children's symptoms by addressing questions commonly asked by children and families...
March 9, 2020: Archives of Disease in Childhood
Fallon Cook, Laura J Conway, Rebecca Giallo, Deirdre Gartland, Emma Sciberras, Stephanie Brown
OBJECTIVE: To determine whether infants with severe persistent sleep problems are at increased risk of (1) meeting diagnostic criteria for a psychiatric disorder (age 10 years), and (2) having elevated symptoms of mental health difficulties (ages 4 and 10 years), in comparison with infants with settled sleep. DESIGN AND SETTING: Prospective longitudinal community cohort study-the Maternal Health Study. Mothers completed questionnaires/interviews at 15 weeks' gestation; 3, 6, 9 and 12 months post partum; and when their child turned 4 and 10 years old...
March 9, 2020: Archives of Disease in Childhood
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