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JOURNAL ARTICLE
Ammar A Javed, Ingmar F Rompen, Iris W J M van Goor, Thomas F Stoop, Paul Andel, Omar Mahmud, Asad Saulat Fatimi, Joseph R Habib, Nabiha A Mughal, Thijs Schouten, Kelly Lafaro, Richard A Burkhart, William R Burns, Hjalmar C van Santvoort, Marcel den Dulk, Freek Daams, J Sven D Mieog, Martijn W J Stommel, Gijs A Patijn, Ignace de Hingh, Sebastiaan Festen, Maarten W Nijkamp, Joost M Klaase, Daan J Lips, Jan H Wijsman, Erwin van der Harst, Eric Manusama, Casper H J van Eijck, Bas Groot Koerkamp, Geert Kazemier, Olivier R Busch, I Quintus Molenaar, Lois A Daamen, Jin He, Christopher L Wolfgang, Marc G Besselink
OBJECTIVE: To measure the rate of LTS in resected PDAC and determine the association between predictors of OS and LTS. SUMMARY BACKGROUND DATA: Long-term survival (>5 y, LTS) remains rare in pancreatic ductal adenocarcinoma (PDAC). Multiple predictors of overall survival (OS) are known but their association with LTS remains unclear. METHODS: An international, multicenter retrospective study was conducted. Included were patients from 2012-2019 with resected PDAC...
September 17, 2024: Annals of Surgery
#22
JOURNAL ARTICLE
Nicole Cimbak, Jennifer M Perez, Alireza Akhondi-Asl, Sally H Vitali, Nilesh M Mehta, Farokh R Demehri, Belinda Hsi Dickie, Jill M Zalieckas
OBJECTIVE: To determine practice variation in surgical management of co-morbidities in pediatric patients with Congenital Diaphragmatic Hernia (CDH). BACKGROUND: A higher percentage of CDH patients are surviving to discharge, accompanied by an increase in morbidity requiring surgical interventions such as tracheostomy and gastrostomy tube insertion. The frequency, trends, and regional variations in operative management of these co-morbidities in this population are unclear...
September 17, 2024: Annals of Surgery
#23
JOURNAL ARTICLE
Philippe Rouanet, Mario Guerrieri, Pablo Lemercier, Emre Balik, Eddy Cotte, Antonino Spinelli, Marcos Gómez-Ruiz, Albert Wolthuis, Emilio Bertani, Anne Dubois
OBJECTIVE: To compare total mesorectal excision (TME) techniques combined with sphincter-sparing procedure in high-risk patients (HRPs). BACKGROUND: TME is the standard treatment for rectal cancer, but can be challenging in HRPs. The available surgical approaches must be compared, especially in HRPs. METHODS: Prospective, observational, multicenter trial to compare laparotomy (OTME), laparoscopy (LTME), robotic-assisted surgery (RTME), and transanal surgery (TaTME) in HRPs...
September 12, 2024: Annals of Surgery
#24
JOURNAL ARTICLE
David K C Cooper, Leonardo V Riella, Tatsuo Kawai, Jay A Fishman, Winfred W Williams, Nahel Elias, Joren C Madsen, Richard N Pierson
In vitro studies indicate that kidney transplantation from gene-edited pigs in which expression of all three of the known glycan xenoantigens has been deleted may be more challenging in nonhuman primates (NHPs) than it will be in human recipients. Furthermore, pig-to-human xenotransplantation offers several other advantages - (i) the patient can communicate with the surgical team; (ii) recipient microbiological monitoring and environment will be clinical-grade; and (iii) sophisticated graft monitoring and imaging techniques, (v) therapeutic interventions, e...
September 12, 2024: Annals of Surgery
#25
JOURNAL ARTICLE
Yuhki Koike, Akira Mizoguchi, Keiichi Uchida, Yuki Sato, Koki Higashi, Yuka Nagano, Kohei Matsushita, Kousyoku Sai, Aika Kaito-Yamagishi, Shujie Wang, Tetsuro Kayahara, Yoshinaga Okugawa, Kyosuke Tanaka, Mikihiro Inoue, Kazuo Funabiki, Kazushi Kimura, Hidemasa Goto, Mizuki Yuge, Yuhei Nishimura, Hiroto Yuasa, Yuji Toiyama
OBJECTIVE: In living tissue, it has been difficult to make microscopic-level observations without damaging the tissue. SUMMARY BACKGROUND DATA: We have invented a novel intravital fluorescent observation method (IFOM) for real-time tissue observation, combining multi-photon laser scanning microscopy (MPLSM) with curcumin vital staining (CVS-IFOM). The aim of this study was to use CVS-IFOM to analyze the enteric nervous system (ENS) in mice and human patients with hypoganglionosis and Hirschsprung disease...
September 12, 2024: Annals of Surgery
#26
JOURNAL ARTICLE
Joseph R Habib, Ingmar F Rompen, Benedict Kinny-Köster, Brady A Campbell, Paul C M Andel, Greg D Sacks, Adrian T Billeter, Hjalmar C van Santvoort, Lois A Daamen, Ammar A Javed, Beat P Müller-Stich, Marc G Besselink, Markus W Büchler, Jin He, Christopher L Wolfgang, I Quintus Molenaar, Martin Loos
OBJECTIVE: To assess the prognostic impact of margin status in patients with resected intraductal papillary mucinous neoplasms (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC) and to inform future intraoperative decision-making on handling differing degrees of dysplasia on frozen section. SUMMARY BACKGROUND DATA: The ideal oncologic surgical outcome is a negative transection margin with normal pancreatic epithelium left behind. However, the prognostic significance of reresecting certain degrees of dysplasia or invasive cancer at the pancreatic neck margin during pancreatectomy for IPMN-derived PDAC is debatable...
September 12, 2024: Annals of Surgery
#27
JOURNAL ARTICLE
Abraham J Matar, Elissa Falconer, Michelle LaBella, Muneera R Kapadia, Carla F Justiniano, Kinga Skowron Olortegui, Randolph Steinhagen, Kurt Schultz, Anurag Pratap, Ira Leeds, Lauren Weaver, Wolfgang Gaertner, Erik B Finger, Mary Thompson, Lucas Fair, Alessandro Fichera, Brendan P Lovasik, William C Chapman, Catherine Lb McGeoch, Mary Catherine Camacho, Marwan Kazimi, Steven C Kim, Virginia O Shaffer, Jahnavi K Srinivasan
OBJECTIVE: To investigate the long-term outcomes of patients with combined primary sclerosing cholangitis/inflammatory bowel disease (PSC-IBD) undergoing both liver transplantation (LT) and total abdominal colectomy (TAC). SUMMARY BACKGROUND DATA: The fraction of patients with PSC-IBD that require both LT and TAC is small, thereby limiting significant conclusions regarding long-term outcomes. METHODS: Adult and pediatric patients from nine centers from the US IBD Surgery Collaborative who underwent staged LT and TAC for PSC-IBD were included...
September 11, 2024: Annals of Surgery
#28
JOURNAL ARTICLE
Hye-Sol Jung, Youngmin Han, Yoon Soo Chae, Won-Gun Yun, Young Jae Cho, Younsoo Seo, Go Won Choi, Haeryoung Kim, Kyoung Bun Lee, Dong Ho Lee, Wooil Kwon, Joon Seong Park, Jin-Young Jang
OBJECTIVE: To evaluate the diagnostic performance of surgical indications of the revised International Association of Pancreatology (IAP) 2023 guidelines compared to the IAP 2017 and European 2018 guidelines. SUMMARY BACKGROUND DATA: The revised IAP guidelines for surgical indications for branch duct (BD) intraductal papillary mucinous neoplasms (IPMN) include the presence of at least two worrisome features without mandatory endoscopic ultrasound. METHODS: Among 663 patients who underwent resection for pathologically confirmed IPMN in a tertiary hospital between 2013 and 2023, 556 patients with BD or mixed-type IPMN were retrospectively reviewed...
September 11, 2024: Annals of Surgery
#29
JOURNAL ARTICLE
Stephen A Stearns, Alexander R Farid, Anupam B Jena
OBJECTIVE: To compare divorce prevalence among surgeons with that of non-surgeon physicians. SUMMARY BACKGROUND DATA: The demanding nature of a career in surgery uniquely challenges the social wellbeing of a surgeon; however, its impact on marital health has not yet been well described. METHODS: A cross-sectional study was conducted using publicly available U.S. Census data from 2017-2021 to investigate prevalence of divorce across different occupations...
September 11, 2024: Annals of Surgery
#30
JOURNAL ARTICLE
Charnwit Assawasirisin, Peter Fagenholz, Motaz Qadan, Yasmin Hernandez-Barco, Satita Aimprasittichai, Avinash Kambadakone, Mari Mino-Kenudson, Amarachi Ike, Sheng-Yin Chen, Chen Sheng, William Brugge, Andrew L Warshaw, Keith D Lillemoe, Carlos Fernández-Del Castillo
OBJECTIVE: To describe the long-term natural history of Branch duct intraductal papillary mucinous neoplasm (BD-IPMN). BACKGROUND: The BD-IPMN is a known precursor of pancreatic cancer, yet its long-term natural history is largely unknown. METHODS: We retrospectively reviewed patients with BD-IPMN who were followed at the Massachusetts General Hospital for at least ten years without surgical intervention. Patient and cyst characteristics, development of worrisome features (WF), need for surgery, and malignancy were recorded...
September 10, 2024: Annals of Surgery
#31
JOURNAL ARTICLE
Qiang Zhao, Jiahao Li, Zepeng Lin, Yunhua Tang, Daopeng Yang, Meiting Qin, Xue Ma, Haibin Ji, Honghui Chen, Tielong Wang, Maogen Chen, Weiqiang Ju, Dongping Wang, Zhiyong Guo, Xiaofeng Zhu, Jia Dan, Anbin Hu, Xiaoshun He
OBJECTIVE: Evaluating the safety and efficacy of implanting a liver with islet grafts into patients with end-stage liver disease and diabetes mellitus (DM). BACKGROUND: DM and end-stage liver diseases are significant health concern worldwide, often coexisting and mutually influencing each other. Addressing both diseases simultaneously is paramount. METHODS: We utilized the islet transplantation combined ischemia-free liver transplantation (ITIFLT) technique to treat a patient with hepatocellular carcinoma (HCC) and type 2 diabetes mellitus (T2DM)...
September 9, 2024: Annals of Surgery
#32
JOURNAL ARTICLE
Hang Cao, Qiang Zheng, Chaoqiang Deng, Zichen Fu, Xuxia Shen, Yan Jin, Yongguo Yang, Bin Qian, Chunyan Yuan, Weihua Wang, Lei Zhang, Qingping Song, Shuying Zuo, Junjie Ma, Shuqing You, Senzhong Zheng, Qingli Gao, Guangli Su, Yang Zhang, Haiquan Chen, Yuan Li
OBJECTIVE: To investigate the value of intraoperative assessment of spread through air spaces (STAS) on frozen sections (FS) in peripheral small-sized lung adenocarcinoma. BACKGROUND: Surgical decision-making based on FS diagnosis of STAS may be useful to prevent local control failure after sublobar resection. METHODS: We conducted a multicenter prospective observational study of consecutive patients with cT1N0M0 invasive lung adenocarcinoma to evaluate the accuracy of FS for the intraoperative detection of STAS...
September 6, 2024: Annals of Surgery
#33
JOURNAL ARTICLE
Rudolf van den Berg, L Matthijs van den Dop, Lucas Timmermans, Michiel van den Berg, Robert E G J M Pierik, Willem A R Zwaans, Daniel Reim, Steven E Buijk, Jerome P van Brussel, Johan F Lange, Johannes J Jeekel, Pieter J Tanis
OBJECTIVE: This study aimed to evaluate all mesh-related problems during reoperations after mesh-reinforcement 15 years after the start of the PRIMA trial. SUMMARY BACKGROUND DATA Prophylactic mesh reinforcement during closure of a midline laparotomy has proven to reduce the incidence of incisional hernia, especially in high-risk patients, but long-term mesh-related morbidity is largely unknown. METHODS: Patients receiving a prophylactic onlay or retro-rectus mesh in the PRIMA trial between 2009 and 2012 were included on an as-treated basis from participating centers that made reoperation notes available...
September 6, 2024: Annals of Surgery
#34
JOURNAL ARTICLE
Takuya Shiraishi, Yuji Nishizawa, Mifumi Nakajima, Ryoko Kado, Hiroomi Ogawa, Satoh Naomi, Yohei Owada, Tsuyoshi Enomoto, Shinji Yazawa, Yukihiro Hamahata, Yumi Isogami, Kazuo Kitagawa, Maki Sakamoto, Hiroya Enomoto, Akiko Egawa, Daichi Kitaguchi, Hiro Hasegawa, Koji Ikeda, Yuichiro Tsukada, Masaaki Ito
OBJECTIVE: This study aimed to understand the effectiveness of regular care in reducing the incidence of severe peristomal skin disorders, as well as to identify their risk factors. SUMMARY BACKGROUND DATA: Peristomal skin disorders occur frequently in outpatient settings and require appropriate intervention. It remains, however, to be demonstrated when the need to follow up these patients decreases and whether assessing severity of peristomal skin disorders is useful...
September 6, 2024: Annals of Surgery
#35
JOURNAL ARTICLE
Tommaso Violante, Davide Ferrari, Marco Novelli, Kevin T Behm, William R Perry, Kellie L Mathis, Eric J Dozois, Amit Merchea, Sherief S Shawki, David W Larson
OBJECTIVE: To compare robotic-assisted proctectomy with ileal pouch-anal anastomosis (R-IPAA) outcomes and laparoscopic proctectomy with ileal pouch-anal anastomosis (L-IPAA) within a specialized robotic surgery center, using matching techniques to minimize potential confounding factors. SUMMARY BACKGROUND DATA: Minimally invasive approaches, particularly laparoscopy, have improved outcomes for IBD and FAP patients undergoing IPAA. Robotic-assisted surgery offers potential technical advantages, but its definitive superiority over laparoscopy in this context remains under debate...
September 5, 2024: Annals of Surgery
#36
JOURNAL ARTICLE
Jie Hu, Yuxin Guo, Xiaoying Wang, Marcus Yeow, Andrew G R Wu, David Fuks, Olivier Soubrane, Safi Dokmak, Salvatore Gruttadauria, Giuseppe Zimmitti, Francesca Ratti, Yutaro Kato, Olivier Scatton, Paulo Herman, Davit L Aghayan, Marco V Marino, Roland S Croner, Vincenzo Mazzaferro, Adrian K H Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Mengqiu Yin, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Alejandro Mejia, James O Park, Fernando Rotellar, Gi-Hong Choi, Ricardo Robles-Campos, Kiyoshi Hasegawa, Rutger-Jan Swijnenburg, Robert P Sutcliffe, Johann Pratschke, Eric C H Lai, Charing C N Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, T Peter Kingham, Moritz Schmelzle, Jason Hawksworth, Yufu Peng, Alessandro Ferrero, Giuseppe Maria Ettorre, Daniel Cherqui, Xiao Liang, Go Wakabayashi, Roberto I Troisi, Umberto Cillo, Tan-To Cheung, Motokazu Sugimoto, Atsushi Sugioka, Ho-Seong Han, Tran Cong Duy Long, Mohammad Abu Hilal, Wanguang Zhang, Yonggang Wei, Kuo-Hsin Chen, Luca Aldrighetti, Bjorn Edwin, Rong Liu, Brian K P Goh
OBJECTIVE: To compare the outcomes of robotic minor liver resections (RMLR) versus laparoscopic (L) MLR of the anterolateral segments. BACKGROUND: Robotic liver surgery has been gaining prominence over the years with increasing usage for a myriad of hepatic resections. Robotic liver resections(RLR) has demonstrated non-inferiority to laparoscopic(L)LR while illustrating advantages over conventional laparoscopy especially for technically difficult and major LR. However, the advantage of RMLR for the anterolateral(AL) (segments II, III, IVb, V and VI) segments, has not been clearly demonstrated...
September 5, 2024: Annals of Surgery
#37
JOURNAL ARTICLE
Norman G Nicolson, Joseph A Tandurella, Lawrence W Wu, Jignasha Patel, Eli Morris, Toni T Seppälä, Samantha Guinn, Haley Zlomke, Christopher R Shubert, Kelly J Lafaro, William R Burns, John L Cameron, Jin He, Elana J Fertig, Elizabeth M Jaffee, Jacquelyn W Zimmerman, Richard A Burkhart
OBJECTIVE: We integrate a new approach to chemosensitivity data for clinically-relevant regimen matching, and demonstrate the relationship with clinical outcomes in a large PDO biobank. SUMMARY BACKGROUND DATA: Pancreatic ductal adenocarcinoma (PDAC) usually recurs following potentially curative resection. Prior studies related patient-derived organoid (PDO) chemosensitivity with clinical responses. METHODS: PDOs were established from pre-treatment biopsies in a multi-institution clinical trial (n=21) and clinical specimens at a high-volume pancreatectomy center (n=74, of which 48 were pre-treated)...
September 4, 2024: Annals of Surgery
#38
JOURNAL ARTICLE
Elisa Caron, Sai Divya Yadavalli, Mohit Manchella, Gabriel Jabbour, Jorge L Gomez-Mayorga, Roger B Davis, Virendra I Patel, David H Stone, Mark F Conrad, Marc L Schermerhorn
BACKGROUND: Chronic kidney disease (CKD) increases morbidity and mortality in most vascular procedures. However, a binary classification of estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2, which is often used in both modeling and clinical trials, may not be optimal for predicting clinical outcomes. OBJECTIVE: Determine the optimal eGFR cutoff for use in risk stratification and prediction models. METHODS: Vascular Quality Initiative (VQI) data for non-emergent, first-time OAR, EVAR, TEVAR, CEA, CAS, PVI, Supra- and infra-inguinal bypass were analyzed from to 2013-2023 and divided into cohorts based on eGFR (≥60, 45-59, 30-44, <30, and preoperative dialysis)...
September 4, 2024: Annals of Surgery
#39
JOURNAL ARTICLE
Rachel C Kim, Giampaolo Perri, Dario M Rocha Castellanos, Hyesol Jung, Michael J Kirsch, Greg D Sacks, Julie Perinel, Brian Goh, Max Heckler, Thilo Hackert, Mustapha Adham, Christopher Wolfgang, Marco Del-Chiaro, Richard Schulick, Jin-Young Jang, Carlos Fernandez Del Castillo, Roberto Salvia, Giovanni Marchegiani, Eugene P Ceppa, C Max Schmidt, Alex M Roch
BACKGROUND: Little is known about the prognostic significance of pancreatic duct (PD) dilation following pancreatoduodenectomy for intraductal papillary mucinous neoplasms (IPMN). Although PD dilation is typically the hallmark radiographic feature of IPMN, other causes of PD dilation exist, including anastomotic stricture, pancreatitis, senescence, and postsurgical passive dilation. Therefore, PD dilation after pancreatoduodenectomy for IPMN represents a diagnostic and management dilemma...
September 3, 2024: Annals of Surgery
#40
JOURNAL ARTICLE
Jon M Harrison, Heather Day, Katherine Arnow, R Fari Ngongoni, Abel Joseph, Taylor Aldridge, Kristan J Wheeler, Jon C DeLong, Jay R Bergquist, Patrick J Worth, Monica M Dua, Shai Friedland, Walter Park, Samer Eldika, Joo Ha Hwang, Brendan C Visser
OBJECTIVE: To compare outcomes of laparoscopic transgastric necrosectomy (LTN) and direct endoscopic necrosectomy (DEN) in the management of retrogastric walled-off necrosis. SUMMARY OF BACKGROUND DATA: Surgical and endoscopic transgastric approaches are used to manage retrogastric pancreatic necrosis. Studies comparing these treatment modalities are lacking but would influence contemporary practice patterns. METHODS: LTN or DEN treated patients at Stanford University Hospital between 2011 and 2023 were identified...
September 3, 2024: Annals of Surgery
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