Fanlei Hu, Lianjie Shi, Xiaohang Liu, Yingjia Chen, Xia Zhang, Yuan Jia, Xu Liu, Jianping Guo, Huaqun Zhu, Hongjiang Liu, Liling Xu, Yingni Li, Ping Wang, Xiangyu Fang, Jimeng Xue, Yang Xie, Chaonan Wei, Jing Song, Xi Zheng, Yan-Ying Liu, Yuhui Li, Limin Ren, Dakang Xu, Liwei Lu, Xiaoyan Qiu, Rong Mu, Jing He, Min Wang, Xuan Zhang, Wanli Liu, Zhanguo Li
OBJECTIVES: B10 and B10pro cells suppress immune responses via secreting interleukin (IL)-10. However, their regulators and underlying mechanisms, especially in human autoimmune diseases, are elusive. This study aimed to address these questions in rheumatoid arthritis (RA), one of the most common highly disabling autoimmune diseases. METHODS: The frequencies and functions of B10 and B10pro cells in healthy individuals and patients with RA were first analysed. The effects of proinflammatory cytokines, particularly tumour necrosis factor (TNF)-α on the quantity, stability and pathogenic phenotype of these cells, were then assessed in patients with RA before and after anti-TNF therapy...
February 1, 2024: Annals of the Rheumatic Diseases