journal
https://read.qxmd.com/read/38413169/shift-in-perspective-autoimmunity-protecting-against-rheumatoid-arthritis
#21
REVIEW
Yibo He, Mike Aoun, Zhongwei Xu, Rikard Holmdahl
A hallmark of rheumatoid arthritis (RA) is the increased levels of autoantibodies preceding the onset and contributing to the classification of the disease. These autoantibodies, mainly anti-citrullinated protein antibody (ACPA) and rheumatoid factor, have been assumed to be pathogenic and many attempts have been made to link them to the development of bone erosion, pain and arthritis. We and others have recently discovered that most cloned ACPA protect against experimental arthritis in the mouse. In addition, we have identified suppressor B cells in healthy individuals, selected in response to collagen type II, and these cells decrease in numbers in RA...
February 27, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38413168/disease-activity-drives-divergent-epigenetic-and-transcriptomic-reprogramming-of-monocyte-subpopulations-in-systemic-lupus-erythematosus
#22
JOURNAL ARTICLE
Anna Guiomar Ferreté-Bonastre, Mónica Martínez-Gallo, Octavio Morante-Palacios, Celia Lourdes Calvillo, Josep Calafell-Segura, Javier Rodríguez-Ubreva, Manel Esteller, Josefina Cortés-Hernández, Esteban Ballestar
OBJECTIVES: Systemic lupus erythematosus (SLE) is characterised by systemic inflammation involving various immune cell types. Monocytes, pivotal in promoting and regulating inflammation in SLE, differentiate from classic monocytes into intermediate and non-classic monocytes, assuming diverse roles and changing their proportions in inflammation. In this study, we investigated the epigenetic and transcriptomic profiles of these and novel monocyte subsets in SLE in relation to activity and progression...
February 27, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38413167/what-rheumatologists-need-to-know-about-mrna-vaccines-current-status-and-future-of-mrna-vaccines-in-autoimmune-inflammatory-rheumatic-diseases
#23
REVIEW
Jin Kyun Park, Eun Bong Lee, Kevin L Winthrop
Messenger RNA (mRNA) vaccines as a novel vaccine platform offer new tools to effectively combat both emerging and existing pathogens which were previously not possible. The 'plug and play' feature of mRNA vaccines enables swift design and production of vaccines targeting complex antigens and rapid incorporation of new vaccine constituents as needed. This feature makes them likely to be adopted for widespread clinical use in the future.Currently approved mRNA vaccines include only those against SARS-CoV-2 virus...
February 27, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38408849/interrupting-an-ifn-%C3%AE-dependent-feedback-loop-in-the-syndrome-of-pyogenic-arthritis-with-pyoderma-gangrenosum-and-acne
#24
JOURNAL ARTICLE
Wonyong Lee, Deborah L Stone, Patrycja Hoffmann, Sofia Rosenzweig, Wanxia Li Tsai, Massimo Gadina, Tina Romeo, Chyi-Chia Richard Lee, Davide Randazzo, Pallavi Pimpale Chavan, Kalpana Manthiram, Scott Canna, Yong Hwan Park, Amanda K Ombrello, Ivona Aksentijevich, Daniel L Kastner, Jae Jin Chae
OBJECTIVES: To study the molecular pathogenesis of PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome, a debilitating hereditary autoinflammatory disease caused by dominant mutation in PSTPIP1 . METHODS: Gene knock-out and knock-in mice were generated to develop an animal model. THP1 and retrovirally transduced U937 human myeloid leukaemia cell lines, peripheral blood mononuclear cells, small interfering RNA (siRNA) knock-down, site-directed mutagenesis, cytokine immunoassays, coimmunoprecipitation and immunoblotting were used to study inflammasome activation...
February 26, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38395605/novel-endotypes-of-antisynthetase-syndrome-identified-independent-of-anti-aminoacyl-transfer-rna-synthetase-antibody-specificity-that-improve-prognostic-stratification
#25
JOURNAL ARTICLE
Shiyu Wu, Xinyue Xiao, Yingfang Zhang, Xinxin Zhang, Guochun Wang, Qinglin Peng
OBJECTIVES: To systemically analyse the heterogeneity in the clinical manifestations and prognoses of patients with antisynthetase syndrome (ASS) and evaluate the transcriptional signatures related to different clinical phenotypes. METHODS: A total of 701 patients with ASS were retrospectively enrolled. The clinical presentation and prognosis were assessed in association with four anti-aminoacyl transfer RNA synthetase (ARS) antibodies: anti-Jo1, anti-PL7, anti-PL12 and anti-EJ...
February 23, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38395604/acute-rheumatic-fever-in-the-province-of-manitoba-canada-before-and-after-the-coronavirus-covid-19-pandemic
#26
LETTER
Kayla Edison, Dion Pepelassis, Reeni Soni, Daryl Schantz, Ilan Buffo
No abstract text is available yet for this article.
February 23, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38388519/correspondence-on-eular-recommendations-for-the-management-of-anca-associated-vasculitis-2022-update-by-hellmich-et-al
#27
LETTER
Joanna C Robson, Montserrat M Díaz Encarnación, Peter Verhoeven, Raquel Olivenza Antón, Monica Balcells-Oliver, Tamara Popov, Sara Monti, Andreas Kronbichler
No abstract text is available yet for this article.
February 22, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38378236/immune-response-to-post-translationally-modified-proteins-in-rheumatoid-arthritis-what-makes-it-special
#28
REVIEW
Diane van der Woude, René E M Toes
Rheumatoid arthritis (RA) exhibits common characteristics with numerous other autoimmune diseases, including the presence of susceptibility genes and the presence of disease-specific autoantibodies. Anti-citrullinated protein antibodies (ACPA) are the hallmarking autoantibodies in RA and the anti-citrullinated protein immune response has been implicated in disease pathogenesis. Insight into the immunological pathways leading to anti-citrullinated protein immunity will not only aid understanding of RA pathogenesis, but may also contribute to elucidation of similar mechanisms in other autoantibody-positive autoimmune diseases...
February 20, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38373844/focal-adhesion-protein-lasp1-links-the-arp2-3-complex-to-adherens-junctions-and-promotes-motility-of-arthritic-fibroblast-like-synoviocytes
#29
LETTER
Denise Beckmann, Annika Krause, Uwe Hansen, Hans P Kiener, Thomas Karonitsch, Stephan Blüml, Joachim Kremerskothen, Hermann Pavenstädt, Thomas Pap, Adelheid Korb-Pap
No abstract text is available yet for this article.
February 19, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38373843/molecular-characterisation-of-lupus-low-disease-activity-state-lldas-and-doris-remission-by-whole-blood-transcriptome-based-pathways-in-a-pan-european-systemic-lupus-erythematosus-cohort
#30
JOURNAL ARTICLE
Ioannis Parodis, Julius Lindblom, Guillermo Barturen, Rafaela Ortega-Castro, Ricard Cervera, Jacques-Olivier Pers, Fernanda Genre, Falk Hiepe, Maria Gerosa, László Kovács, Ellen De Langhe, Silvia Piantoni, Georg Stummvoll, Carlos Vasconcelos, Barbara Vigone, Torsten Witte, Marta E Alarcón-Riquelme, Lorenzo Beretta
OBJECTIVES: To unveil biological milieus underlying low disease activity (LDA) and remission versus active systemic lupus erythematosus (SLE). METHODS: We determined differentially expressed pathways (DEPs) in SLE patients from the PRECISESADS project (NTC02890121) stratified into patients fulfilling and not fulfilling the criteria of (1) Lupus LDA State (LLDAS), (2) Definitions of Remission in SLE remission, and (3) LLDAS exclusive of remission. RESULTS: We analysed data from 321 patients; 40...
February 19, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38373841/-klf2-enhancer-variant-rs4808485-increases-lupus-risk-by-modulating-inflammasome-machinery-and-cellular-homoeostasis
#31
JOURNAL ARTICLE
Manish Kumar Singh, Harikrishna Reddy Rallabandi, Xu-Jie Zhou, Yuan-Yuan Qi, Zhan-Zheng Zhao, Ting Gan, Hong Zhang, Loren L Looger, Swapan K Nath
OBJECTIVE: A recent genome-wide association study linked KLF2 as a novel Asian-specific locus for systemic lupus erythematosus (SLE) susceptibility. However, the underlying causal functional variant(s), cognate target gene(s) and genetic mechanisms associated with SLE risk are unknown. METHODS: We used bioinformatics to prioritise likely functional variants and validated the best candidate with diverse experimental techniques, including genome editing. Gene expression was compared between healthy controls (HCs) and patients with SLE with or without lupus nephritis (LN+, LN-)...
February 19, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38331590/annals-of-the-rheumatic-diseases-collection-on-pregnancy-2018-2023-observational-data-driven-knowledge
#32
REVIEW
Kate Duhig, Kimme L Hyrich
Pregnancy can be an exciting time but for those living with rheumatic musculoskeletal diseases (RMDs), it can also be a time fraught with concern, including what effect pregnancy will have on the underlying RMD and what effect the RMD may have on the pregnancy and the baby, including the effects of medications. Generating an evidence base in pregnancy is challenging. Few interventional trials of medications in RMD pregnancies have ever been conducted, often for concerns of safety for both the mother and the child...
February 8, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38331589/comorbidity-clusters-in-patients-with-rheumatoid-arthritis-identify-a-patient-phenotype-with-a-favourable-prognosis
#33
JOURNAL ARTICLE
Cynthia S Crowson, Elizabeth J Atkinson, Vanessa L Kronzer, Bradly A Kimbrough, Courtney A Arment, Lynne S Peterson, Kerry Wright, Thomas G Mason, Delamo I Bekele, John M Davis, Elena Myasoedova
OBJECTIVES: We aimed to cluster patients with rheumatoid arthritis (RA) based on comorbidities and then examine the association between these clusters and RA disease activity and mortality. METHODS: In this population-based study, residents of an eight-county region with prevalent RA on 1 January 2015 were identified. Patients were followed for vital status until death, last contact or 31 December 2021. Diagnostic codes for 5 years before the prevalence date were used to define 55 comorbidities...
February 8, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38331588/single-cell-transcriptome-analyses-reveal-disturbed-decidual-homoeostasis-in-obstetric-antiphospholipid-syndrome
#34
JOURNAL ARTICLE
Chenyang Lu, Rui Gao, Pingying Qing, Xun Zeng, Xin Liao, Meng Cheng, Lang Qin, Yi Liu
OBJECTIVES: Obstetric antiphospholipid syndrome (OAPS) is an autoimmune disease characterised by the presence of antiphospholipid antibodies in circulation and pathological pregnancy. However, the pathogenesis of OAPS remains unknown. We aimed to reveal cellular compositions and molecular features of decidual cells involved in the development of OAPS using single-cell RNA sequencing (scRNA-seq). METHODS: We performed unbiased scRNA-seq analysis on the first-trimester decidua from five OAPS patients and five healthy controls (HCs), followed by validations with flow cytometry, immunohistochemical staining and immunofluorescence in a larger cohort...
February 8, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38233104/can-rheumatologists-unequivocally-diagnose-axial-spondyloarthritis-in-patients-with-chronic-back-pain-of-less-than-2-years-duration-primary-outcome-of-the-2-year-spondyloarthritis-caught-early-space-cohort
#35
JOURNAL ARTICLE
Mary Lucy Marques, Sofia Ramiro, Miranda van Lunteren, Rosalinde Anne Stal, Robert Bm Landewé, Marleen van de Sande, Karen Minde Fagerli, Inger Jorid Berg, Maikel van Oosterhout, Sofia Exarchou, Roberta Ramonda, Désirée van der Heijde, Floris A van Gaalen
OBJECTIVES: To investigate the prevalence of axial spondyloarthritis (axSpA) in patients with chronic back pain (CBP) of less than 2 years (2y) duration referred to the rheumatologist, the development of diagnosis over time, and patient characteristics of those developing definite (d-)axSpA over 2y. METHODS: We analysed the 2y data from SPondyloArthritis Caught Early, a European cohort of patients (<45 years) with CBP (≥3 months, ≤2y) of unknown origin...
February 8, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38325909/gender-imbalance-in-expert-panels-of-recommendations-in-rheumatology
#36
LETTER
Xufei Luo, Yaxuan Ren, Yaolong Chen
No abstract text is available yet for this article.
February 7, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38325908/unveiling-inflammatory-and-prehypertrophic-cell-populations-as-key-contributors-to-knee-cartilage-degeneration-in-osteoarthritis-using-multi-omics-data-integration
#37
JOURNAL ARTICLE
Yue Fan, Xuzhao Bian, Xiaogao Meng, Lei Li, Laiyi Fu, Yanan Zhang, Long Wang, Yan Zhang, Dalong Gao, Xiong Guo, Mikko Juhani Lammi, Guangdun Peng, Shiquan Sun
OBJECTIVES: Single-cell and spatial transcriptomics analysis of human knee articular cartilage tissue to present a comprehensive transcriptome landscape and osteoarthritis (OA)-critical cell populations. METHODS: Single-cell RNA sequencing and spatially resolved transcriptomic technology have been applied to characterise the cellular heterogeneity of human knee articular cartilage which were collected from 8 OA donors, and 3 non-OA control donors, and a total of 19 samples...
February 7, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38320811/2023-eular-recommendations-on-imaging-in-diagnosis-and-management-of-crystal-induced-arthropathies-in-clinical-practice
#38
JOURNAL ARTICLE
Peter Mandl, Maria Antonietta D'Agostino, Victoria Navarro-Compán, Irina Geßl, Garifallia Sakellariou, Abhishek Abhishek, Fabio Becce, Nicola Dalbeth, Hang-Korng Ea, Emilio Filippucci, Hilde Berner Hammer, Annamaria Iagnocco, Annette de Thurah, Esperanza Naredo, Sebastien Ottaviani, Tristan Pascart, Fernando Pérez-Ruiz, Irene A Pitsillidou, Fabian Proft, Juergen Rech, Wolfgang A Schmidt, Luca Maria Sconfienza, Lene Terslev, Brigitte Wildner, Pascal Zufferey, Georgios Filippou
OBJECTIVE: To formulate evidence-based recommendations and overarching principles on the use of imaging in the clinical management of crystal-induced arthropathies (CiAs). METHODS: An international task force of 25 rheumatologists, radiologists, methodologists, healthcare professionals and patient research partners from 11 countries was formed according to the EULAR standard operating procedures. Fourteen key questions on the role of imaging in the most common forms of CiA were generated...
February 6, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38316532/an-ulcerating-skin-tumour-in-a-patient-with-rheumatoid-arthritis
#39
JOURNAL ARTICLE
Laura C M Schenning, Rosanne Ottevanger, Koen D Quint, Sander W Tas
No abstract text is available yet for this article.
February 5, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38302261/proinflammatory-phenotype-of-b10-and-b10pro-cells-elicited-by-tnf-%C3%AE-in-rheumatoid-arthritis
#40
JOURNAL ARTICLE
Fanlei Hu, Lianjie Shi, Xiaohang Liu, Yingjia Chen, Xia Zhang, Yuan Jia, Xu Liu, Jianping Guo, Huaqun Zhu, Hongjiang Liu, Liling Xu, Yingni Li, Ping Wang, Xiangyu Fang, Jimeng Xue, Yang Xie, Chaonan Wei, Jing Song, Xi Zheng, Yan-Ying Liu, Yuhui Li, Limin Ren, Dakang Xu, Liwei Lu, Xiaoyan Qiu, Rong Mu, Jing He, Min Wang, Xuan Zhang, Wanli Liu, Zhanguo Li
OBJECTIVES: B10 and B10pro cells suppress immune responses via secreting interleukin (IL)-10. However, their regulators and underlying mechanisms, especially in human autoimmune diseases, are elusive. This study aimed to address these questions in rheumatoid arthritis (RA), one of the most common highly disabling autoimmune diseases. METHODS: The frequencies and functions of B10 and B10pro cells in healthy individuals and patients with RA were first analysed. The effects of proinflammatory cytokines, particularly tumour necrosis factor (TNF)-α on the quantity, stability and pathogenic phenotype of these cells, were then assessed in patients with RA before and after anti-TNF therapy...
February 1, 2024: Annals of the Rheumatic Diseases
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