journal
https://read.qxmd.com/read/38233104/can-rheumatologists-unequivocally-diagnose-axial-spondyloarthritis-in-patients-with-chronic-back-pain-of-less-than-2-years-duration-primary-outcome-of-the-2-year-spondyloarthritis-caught-early-space-cohort
#21
JOURNAL ARTICLE
Mary Lucy Marques, Sofia Ramiro, Miranda van Lunteren, Rosalinde Anne Stal, Robert Bm Landewé, Marleen van de Sande, Karen Minde Fagerli, Inger Jorid Berg, Maikel van Oosterhout, Sofia Exarchou, Roberta Ramonda, Désirée van der Heijde, Floris A van Gaalen
OBJECTIVES: To investigate the prevalence of axial spondyloarthritis (axSpA) in patients with chronic back pain (CBP) of less than 2 years (2y) duration referred to the rheumatologist, the development of diagnosis over time, and patient characteristics of those developing definite (d-)axSpA over 2y. METHODS: We analysed the 2y data from SPondyloArthritis Caught Early, a European cohort of patients (<45 years) with CBP (≥3 months, ≤2y) of unknown origin...
February 8, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38325909/gender-imbalance-in-expert-panels-of-recommendations-in-rheumatology
#22
LETTER
Xufei Luo, Yaxuan Ren, Yaolong Chen
No abstract text is available yet for this article.
February 7, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38325908/unveiling-inflammatory-and-prehypertrophic-cell-populations-as-key-contributors-to-knee-cartilage-degeneration-in-osteoarthritis-using-multi-omics-data-integration
#23
JOURNAL ARTICLE
Yue Fan, Xuzhao Bian, Xiaogao Meng, Lei Li, Laiyi Fu, Yanan Zhang, Long Wang, Yan Zhang, Dalong Gao, Xiong Guo, Mikko Juhani Lammi, Guangdun Peng, Shiquan Sun
OBJECTIVES: Single-cell and spatial transcriptomics analysis of human knee articular cartilage tissue to present a comprehensive transcriptome landscape and osteoarthritis (OA)-critical cell populations. METHODS: Single-cell RNA sequencing and spatially resolved transcriptomic technology have been applied to characterise the cellular heterogeneity of human knee articular cartilage which were collected from 8 OA donors, and 3 non-OA control donors, and a total of 19 samples...
February 7, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38320811/2023-eular-recommendations-on-imaging-in-diagnosis-and-management-of-crystal-induced-arthropathies-in-clinical-practice
#24
JOURNAL ARTICLE
Peter Mandl, Maria Antonietta D'Agostino, Victoria Navarro-Compán, Irina Geßl, Garifallia Sakellariou, Abhishek Abhishek, Fabio Becce, Nicola Dalbeth, Hang-Korng Ea, Emilio Filippucci, Hilde Berner Hammer, Annamaria Iagnocco, Annette de Thurah, Esperanza Naredo, Sebastien Ottaviani, Tristan Pascart, Fernando Pérez-Ruiz, Irene A Pitsillidou, Fabian Proft, Juergen Rech, Wolfgang A Schmidt, Luca Maria Sconfienza, Lene Terslev, Brigitte Wildner, Pascal Zufferey, Georgios Filippou
OBJECTIVE: To formulate evidence-based recommendations and overarching principles on the use of imaging in the clinical management of crystal-induced arthropathies (CiAs). METHODS: An international task force of 25 rheumatologists, radiologists, methodologists, healthcare professionals and patient research partners from 11 countries was formed according to the EULAR standard operating procedures. Fourteen key questions on the role of imaging in the most common forms of CiA were generated...
February 6, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38316532/an-ulcerating-skin-tumour-in-a-patient-with-rheumatoid-arthritis
#25
JOURNAL ARTICLE
Laura C M Schenning, Rosanne Ottevanger, Koen D Quint, Sander W Tas
No abstract text is available yet for this article.
February 5, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38302261/proinflammatory-phenotype-of-b10-and-b10pro-cells-elicited-by-tnf-%C3%AE-in-rheumatoid-arthritis
#26
JOURNAL ARTICLE
Fanlei Hu, Lianjie Shi, Xiaohang Liu, Yingjia Chen, Xia Zhang, Yuan Jia, Xu Liu, Jianping Guo, Huaqun Zhu, Hongjiang Liu, Liling Xu, Yingni Li, Ping Wang, Xiangyu Fang, Jimeng Xue, Yang Xie, Chaonan Wei, Jing Song, Xi Zheng, Yan-Ying Liu, Yuhui Li, Limin Ren, Dakang Xu, Liwei Lu, Xiaoyan Qiu, Rong Mu, Jing He, Min Wang, Xuan Zhang, Wanli Liu, Zhanguo Li
OBJECTIVES: B10 and B10pro cells suppress immune responses via secreting interleukin (IL)-10. However, their regulators and underlying mechanisms, especially in human autoimmune diseases, are elusive. This study aimed to address these questions in rheumatoid arthritis (RA), one of the most common highly disabling autoimmune diseases. METHODS: The frequencies and functions of B10 and B10pro cells in healthy individuals and patients with RA were first analysed. The effects of proinflammatory cytokines, particularly tumour necrosis factor (TNF)-α on the quantity, stability and pathogenic phenotype of these cells, were then assessed in patients with RA before and after anti-TNF therapy...
February 1, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38302260/characterised-intron-retention-profiles-in-muscle-tissue-of-idiopathic-inflammatory-myopathy-subtypes
#27
JOURNAL ARTICLE
Yizhi Xiao, Shasha Xie, Hong-Dong Li, Yanjuan Liu, Huali Zhang, Xiaoxia Zuo, Honglin Zhu, Yisha Li, Hui Luo
OBJECTIVES: Idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous autoimmune diseases. Intron retention (IR) serves as an important post-transcriptional and translational regulatory mechanism. This study aims to identify changes in IR profiles in IIM subtypes, investigating their influence on proteins and their correlations with clinical features. METHODS: RNA sequencing and liquid chromatography-tandem mass spectrometry were performed on muscle tissues obtained from 174 patients with IIM and 19 controls, following QC procedures...
February 1, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38290829/single-cell-profiling-reveals-kidney-cd163-dendritic-cell-participation-in-human-lupus-nephritis
#28
JOURNAL ARTICLE
Wei Chen, Bei Jin, Cheng Cheng, Huajing Peng, Xinxin Zhang, Weiping Tan, Ruihan Tang, Xingji Lian, Hui Diao, Ning Luo, Xiaoyan Li, Jinjin Fan, Jian Shi, Changjun Yin, Ji Wang, Sui Peng, Li Yu, Jun Li, Rui-Qi Wu, Dong-Ming Kuang, Guo-Ping Shi, Yi Zhou, Fang Wang, Xiaoyun Jiang
OBJECTIVES: The current work aimed to provide a comprehensive single-cell landscape of lupus nephritis (LN) kidneys, including immune and non-immune cells, identify disease-associated cell populations and unravel their participation within the kidney microenvironment. METHODS: Single-cell RNA and T cell receptor sequencing were performed on renal biopsy tissues from 40 patients with LN and 6 healthy donors as controls. Matched peripheral blood samples from seven LN patients were also sequenced...
January 30, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38272667/epo-promotes-the-progression-of-rheumatoid-arthritis-by-inducing-desialylation-via-increasing-the-expression-of-neuraminidase-3
#29
JOURNAL ARTICLE
Gan Wu, Ben Cao, Haige Zhai, Bin Liu, Yuan Huang, Xiaowei Chen, Hanzhi Ling, Sunwang Ling, Shengwei Jin, Xinyu Yang, Jianguang Wang
OBJECTIVE: Erythropoietin (EPO) known as an erythrocyte-stimulating factor is increased in patients with rheumatoid arthritis (RA). Nevertheless, the function of EPO in the process of RA and relative mechanism needs to be further clarified. METHODS: The level of EPO in serum and synovial fluid from patients with RA and healthy controls was determined by . Collagen-induced arthritis (CIA) mice were constructed to confirm the role of EPO on RA pathogenesis. Differentially expressed genes (DEGs) of EPO-treated fibroblast-like synoviocyte (FLS) were screened by transcriptome sequencing...
January 25, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38262688/male-patients-with-inflammatory-joint-diseases-are-less-likely-than-controls-to-be-childless-results-from-a-norwegian-population-based-cohort-study-of-10-865-patients
#30
JOURNAL ARTICLE
Gudrun David Sigmo, Solveig Hauge, Karl Ove Hufthammer, Marianne Wallenius, Kjell Åsmund Salvesen, Anne Kjersti Nesje Daltveit, Gunnstein Bakland, Bjorg-Tilde Svanes Fevang
OBJECTIVES: To investigate the number of children per man and the proportion of childless men as a proxy of fertility in a national cohort of men with inflammatory joint diseases (IJDs), compared with matched controls from the general population. METHODS: This is a nationwide, population-based retrospective cohort study. Male patients with IJDs (n = 10 865) in the Norwegian Arthritis Registry were individually matched 1:5 on birth year and county of residence with men without IJDs obtained from the National Population Register (n = 54 325)...
January 23, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38242638/morris-ziff
#31
JOURNAL ARTICLE
Philip Cohen, David Ziff, Peter E Lipsky
No abstract text is available yet for this article.
January 19, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38242637/erosive-hand-osteoarthritis-and-sarcopenia-data-from-osteoarthritis-initiative-cohort
#32
JOURNAL ARTICLE
Kamyar Moradi, Robert M Kwee, Bahram Mohajer, Ali Guermazi, Frank W Roemer, Hamza Ahmed Ibad, Ida K Haugen, Francis Berenbaum, Shadpour Demehri
OBJECTIVES: There is no evidence linking specific osteoarthritis (OA) types, such as erosive hand OA (EHOA), with distant generalised changes in muscle composition (sarcopenia), which can potentially be modified. This study pioneers the exploration of the association between EHOA and sarcopenia, both of which are predominantly observed in the older adults. METHODS: Using the Osteoarthritis Initiative cohort, we selected hand OA (modified Kellgren and Lawrence (grade ≥2 in ≥1 hand joint) participants with radiographic central erosions in ≥1 joints (EHOA group) and propensity score-matched hand OA participants with no erosion (non-EHOA group)...
January 19, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38233103/pragmatic-targets-for-moderate-severe-sle-and-their-implications-for-clinical-care-and-trial-design-sustained-doris-or-lldas-for-at-least-6-months-is-sufficient-while-their-attainment-for-at-least-24-months-ensures-high-specificity-for-damage-free-progression
#33
JOURNAL ARTICLE
Sofia Pitsigavdaki, Myrto Nikoloudaki, Panagiotis Garantziotis, Ettore Silvagni, Argyro Repa, Antonio Marangoni, Irini Flouri, Nestor Avgoustidis, Konstantinos Parperis, Antonis Fanouriakis, Marcello Govoni, Prodromos Sidiropoulos, Dimitrios T Boumpas, Alessandra Bortoluzzi, George Bertsias
OBJECTIVES: Treatment targets in systemic lupus erythematosus (SLE) have been validated in unselected-in terms of severity-cohorts, which limits their generalisability. We assessed remission (Definition of Remission in SLE (DORIS)) and Lupus Low Disease Activity State (LLDAS) in a historical cohort of 348 patients with active moderate-to-severe disease and median follow-up of 5 years. METHODS: Active SLE was defined as Physician Global Assessment ≥1.5 and/or SLE Disease Activity Index 2000 ≥6, requiring therapy intensification...
January 17, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38228361/comparison-of-the-effect-of-treatment-with-nsaids-added-to-anti-tnf-therapy-versus-anti-tnf-therapy-alone-on-the-progression-of-structural-damage-in-the-spine-over-2-years-in-patients-with-radiographic-axial-spondyloarthritis-from-the-randomised-controlled
#34
JOURNAL ARTICLE
Fabian Proft, Murat Torgutalp, Burkhard Muche, Valeria Rios Rodriguez, Joachim Listing, Mikhail Protopopov, Judith Rademacher, Hildrun Haibel, Laura Spiller, Anne-Katrin Weber, Maryna Verba, Jan Brandt-Juergens, Uta Kiltz, Maren Sieburg, Swen Jacki, Joachim Sieper, Denis Poddubnyy
OBJECTIVES: The study aimed to evaluate the effect of adding a non-steroidal anti-inflammatory drug (NSAID), celecoxib (CEL), to a tumour necrosis factor inhibitor (TNFi), golimumab (GOL), compared with TNFi monotherapy on radiographic spinal progression in patients with radiographic axial spondyloarthritis (r-axSpA) over 2 years. METHODS: R-axSpA patients, having risk factors for radiographic progression (high disease activity plus C reactive protein >5 mg/L and/or ≥1 syndesmophyte(s)), underwent a 12-week run-in phase with GOL 50 mg every 4 weeks...
January 16, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38216319/withdrawal-of-immunosuppressants-and-low-dose-steroids-in-patients-with-stable-igg4-rd-wins-igg4-rd-an-investigator-initiated-multicentre-open-label-randomised-controlled-trial
#35
JOURNAL ARTICLE
Linyi Peng, Yuxue Nie, Jiaxin Zhou, Lijun Wu, Xiaomei Chen, Fang Wang, Jieqiong Li, Yu Peng, Hui Lu, Lidan Zhao, Mengtao Li, Yan Zhao, Xiaofeng Zeng, Yunyun Fei, Wen Zhang
OBJECTIVES: IgG4-related disease (IgG4-RD) is an immune-mediated, fibroinflammatory disease. Induction treatment with glucocorticoid (GC) is usually effective, but its tendency of relapse makes the strategy for maintenance treatment a challenge. The WInS IgG4-RD (withdraw immunosuppressants (IMs) and steroid in stable IgG4-RD) trial tested whether discontinuation of GC and IM was feasible in stable IgG4-RD. METHODS: The WInS IgG4-RD trial was a multicentre, open-label, randomised controlled trial...
January 12, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38216318/current-myositis-clinical-trials-and-tribulations
#36
JOURNAL ARTICLE
Didem Saygin, Victoria Werth, Julie J Paik, Jin Kyun Park, Merrilee Needham, Ingrid E Lundberg, Lisa Christopher-Stine
With improved understanding of disease pathogenesis and availability of outcome measures, there has been a remarkable increase in the number of therapeutic clinical trials in idiopathic inflammatory myopathies (myositis) over the last three years reaching as many as five trials per site. These trials share similar design and inclusion/exclusion criteria resulting in a competitive clinical trial landscape in myositis. While these are exciting times for the myositis field, we have a number of concerns about the design and conduct of the myositis trials...
January 12, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38212040/eular-recommendations-for-the-non-pharmacological-core-management-of-hip-and-knee-osteoarthritis-2023-update
#37
JOURNAL ARTICLE
Tuva Moseng, Theodora P M Vliet Vlieland, Simone Battista, David Beckwée, Vladimira Boyadzhieva, Philip G Conaghan, Daniela Costa, Michael Doherty, Andrew G Finney, Tsvetoslav Georgiev, Milena Gobbo, Norelee Kennedy, Ingvild Kjeken, Féline P B Kroon, L Stefan Lohmander, Hans Lund, Christian D Mallen, Karel Pavelka, Irene A Pitsillidou, Margaret P Rayman, Anne Therese Tveter, Johanna E Vriezekolk, Dieter Wiek, Gustavo Zanoli, Nina Østerås
INTRODUCTION: Hip and knee osteoarthritis (OA) are increasingly common with a significant impact on individuals and society. Non-pharmacological treatments are considered essential to reduce pain and improve function and quality of life. EULAR recommendations for the non-pharmacological core management of hip and knee OA were published in 2013. Given the large number of subsequent studies, an update is needed. METHODS: The Standardised Operating Procedures for EULAR recommendations were followed...
January 11, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38199795/immunomodulators-and-risk-for-breakthrough-covid-19-after-third-sars-cov-2-mrna-vaccine-among-patients-with-rheumatoid-arthritis-a-cohort-study
#38
LETTER
Abigail E Schiff, Xiaosong Wang, Naomi J Patel, Yumeko Kawano, Jennifer L Hanberg, Emily N Kowalski, Claire E Cook, Kathleen Mm Vanni, Grace Qian, Katarina J Bade, Alene A Saavedra, Shruthi Srivatsan, Zachary K Williams, Rathnam K Venkat, Zachary S Wallace, Jeffrey A Sparks
No abstract text is available yet for this article.
January 10, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38182406/deep-immunophenotyping-reveals-that-autoimmune-and-autoinflammatory-disorders-are-spread-along-two-immunological-axes-capturing-disease-inflammation-levels-and-types
#39
JOURNAL ARTICLE
Nicolas Tchitchek, Marie Binvignat, Alexandra Roux, Fabien Pitoiset, Johanna Dubois, Gwendolyn Marguerit, David Saadoun, Patrice Cacoub, Jérémie Sellam, Francis Berenbaum, Agnès Hartemann, Chloé Amouyal, Roberta Lorenzon, Encarnita Mariotti-Ferrandiz, Michelle Rosenzwajg, David Klatzmann
OBJECTIVES: Based on genetic associations, McGonagle and McDermott suggested a classification of autoimmune and autoinflammatory diseases as a continuum ranging from purely autoimmune to purely autoinflammatory diseases and comprising diseases with both components. We used deep immunophenotyping to identify immune cell populations and molecular targets characterising this continuum. METHODS: We collected blood from 443 patients with one of 15 autoimmune or autoinflammatory diseases and 71 healthy volunteers...
January 5, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38182405/prognostic-model-to-predict-the-incidence-of-radiographic-knee-osteoarthritis
#40
JOURNAL ARTICLE
Rocío Paz-González, Vanesa Balboa-Barreiro, Lucia Lourido, Valentina Calamia, Patricia Fernandez-Puente, Natividad Oreiro, Cristina Ruiz-Romero, Francisco J Blanco
OBJECTIVE: Early diagnosis of knee osteoarthritis (KOA) in asymptomatic stages is essential for the timely management of patients using preventative strategies. We develop and validate a prognostic model useful for predicting the incidence of radiographic KOA (rKOA) in non-radiographic osteoarthritic subjects and stratify individuals at high risk of developing the disease. METHODS: Subjects without radiographic signs of KOA according to the Kellgren and Lawrence (KL) classification scale (KL=0 in both knees) were enrolled in the OA initiative (OAI) cohort and the Prospective Cohort of A Coruña (PROCOAC)...
January 5, 2024: Annals of the Rheumatic Diseases
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