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Kulveer Mankia, Maria-Antonietta D'Agostino, Jorge Murillo-González, Andrew Grainger, Paul Emery
No abstract text is available yet for this article.
May 17, 2019: Annals of the Rheumatic Diseases
#2
Xiao Liu, Wei Zhang, Ming Zhao, Longfei Liu, Limin Liu, Jinghua Wu, Shuangyan Luo, Longlong Wang, Zijun Wang, Liya Lin, Yan Liu, Shiyu Wang, Yang Yang, Lihua Luo, Juqing Jiang, Xie Wang, Yixin Tan, Tao Li, Bochen Zhu, Yi Zhao, Xiaofei Gao, Ziyun Wan, Cancan Huang, Mingyan Fang, Qianwen Li, Huanhuan Peng, Xiangping Liao, Jinwei Chen, Fen Li, Guanghui Ling, Hongjun Zhao, Hui Luo, Zhongyuan Xiang, Jieyue Liao, Yu Liu, Heng Yin, Hai Long, Haijing Wu, Huanming Yang, Jian Wang, Qianjin Lu
OBJECTIVE: T cell receptor (TCR) diversity determines the autoimmune responses in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and is closely associated with autoimmune diseases prognosis and prevention. However, the characteristics of variations in TCR diversity and their clinical significance is still unknown. Large series of patients must be studied in order to elucidate the effects of these variations. METHODS: Peripheral blood from 877 SLE patients, 206 RA patients and 439 healthy controls (HC) were amplified for the TCR repertoire and sequenced using a high-throughput sequencer...
May 17, 2019: Annals of the Rheumatic Diseases
#3
LETTER
Zhenhan Deng, Haifeng Liu, Wei Lu
No abstract text is available yet for this article.
May 17, 2019: Annals of the Rheumatic Diseases
#4
LETTER
Zaixing Yang, Yan Liang
No abstract text is available yet for this article.
May 16, 2019: Annals of the Rheumatic Diseases
#5
Christopher Loh, Sung-Ho Park, Angela Lee, Ruoxi Yuan, Lionel B Ivashkiv, George D Kalliolias
OBJECTIVE: We investigated genome-wide changes in gene expression and chromatin remodelling induced by tumour necrosis factor (TNF) in fibroblast-like synoviocytes (FLS) and macrophages to better understand the contribution of FLS to the pathogenesis of rheumatoid arthritis (RA). METHODS: FLS were purified from patients with RA and CD14+ human monocyte-derived macrophages were obtained from healthy donors. RNA-sequencing, histone 3 lysine 27 acetylation (H3K27ac), chromatin immunoprecipitation-sequencing (ChIP-seq) and assay for transposable accessible chromatin by high throughput sequencing (ATAC-seq) were performed in control and TNF-stimulated cells...
May 16, 2019: Annals of the Rheumatic Diseases
#6
Yasuhiro Kato, JeongHoon Park, Hyota Takamatsu, Atsushi Kumanogoh
No abstract text is available yet for this article.
May 16, 2019: Annals of the Rheumatic Diseases
#7
Luis Eduardo Coelho Andrade, Jan Damoiseaux, Edward K Chan
No abstract text is available yet for this article.
May 15, 2019: Annals of the Rheumatic Diseases
#8
LETTER
Chuiwen Deng, Xiaohui Qu, Shaoyun Cheng, Xiaofeng Zeng, Yongzhe Li, Yunyun Fei
No abstract text is available yet for this article.
May 15, 2019: Annals of the Rheumatic Diseases
#9
Gulsen Ozen, Sofia Pedro, Frederick Wolfe, Kaleb Michaud
OBJECTIVE: To examine the fracture risk with use of disease-modifying antirheumatic drugs (DMARDs), statins, proton pump inhibitors (PPIs), opioids, non-opioid analgesics and psychotropic medications in a US-wide observational rheumatoid arthritis (RA) cohort. METHODS: Patients with RA without prior fracture from 2001 through 2017 in FORWARD, a longitudinal observational registry, were assessed for osteoporosis-related site fractures (vertebra, hip, forearm and humerus)...
May 15, 2019: Annals of the Rheumatic Diseases
#10
Paul Martin, James Ding, Kate Duffus, Vasanthi Priyadarshini Gaddi, Amanda McGovern, Helen Ray-Jones, Annie Yarwood, Jane Worthington, Anne Barton, Gisela Orozco
OBJECTIVES: There is a need to identify effective treatments for rheumatic diseases, and while genetic studies have been successful it is unclear which genes contribute to the disease. Using our existing Capture Hi-C data on three rheumatic diseases, we can identify potential causal genes which are targets for existing drugs and could be repositioned for use in rheumatic diseases. METHODS: High confidence candidate causal genes were identified using Capture Hi-C data from B cells and T cells...
May 15, 2019: Annals of the Rheumatic Diseases
#11
Maria G Tektonidou, Laura Andreoli, Marteen Limper, Zahir Amoura, Ricard Cervera, Nathalie Costedoat-Chalumeau, Maria Jose Cuadrado, Thomas Dörner, Raquel Ferrer-Oliveras, Karen Hambly, Munther A Khamashta, Judith King, Francesca Marchiori, Pier Luigi Meroni, Marta Mosca, Vittorio Pengo, Luigi Raio, Guillermo Ruiz-Irastorza, Yehuda Shoenfeld, Ljudmila Stojanovich, Elisabet Svenungsson, Denis Wahl, Angela Tincani, Michael M Ward
The objective was to develop evidence-based recommendations for the management of antiphospholipid syndrome (APS) in adults. Based on evidence from a systematic literature review and expert opinion, overarching principles and recommendations were formulated and voted. High-risk antiphospholipid antibody (aPL) profile is associated with greater risk for thrombotic and obstetric APS. Risk modification includes screening for and management of cardiovascular and venous thrombosis risk factors, patient education about treatment adherence, and lifestyle counselling...
May 15, 2019: Annals of the Rheumatic Diseases
#12
LETTER
Adrian Y S Lee, Dimitra Beroukas, Peter J Roberts-Thomson
No abstract text is available yet for this article.
May 14, 2019: Annals of the Rheumatic Diseases
#13
LETTER
Hasan Satış, Reyhan Bilici Salman, Aslihan Avanoğlu Güler, Hazan Karadeniz, Şeyma Yıldız, Neslihan Kayahan
No abstract text is available yet for this article.
May 14, 2019: Annals of the Rheumatic Diseases
#14
Wenhui Xie, Yanrong Huang, Shiyu Xiao, Xiaoying Sun, Yong Fan, Zhuoli Zhang
OBJECTIVES: To investigate the effect of Janus kinase inhibitors (Jakinibs) on cardiovascular risk in adult patients with rheumatoid arthritis (RA) via a meta-analysis of randomised controlled trials (RCTs). METHODS: PubMed, Embase and Cochrane library were thoroughly searched for RCTs reporting safety issues in patients with RA receiving Jakinibs, from inception to October 2018. The primary and secondary outcomes were all cardiovascular events (CVEs) and major adverse cardiovascular events (MACEs)/venous thromboembolism events (VTEs)...
May 14, 2019: Annals of the Rheumatic Diseases
#15
Jan Damoiseaux, Edward K Chan
No abstract text is available yet for this article.
May 14, 2019: Annals of the Rheumatic Diseases
#16
LETTER
Ioannis Parodis, Mandana Nikpour
No abstract text is available yet for this article.
May 10, 2019: Annals of the Rheumatic Diseases
#17
LETTER
Michael Levraut, Nihal Martis, Philippe Viau, Felipe Suarez, Viviane Queyrel
No abstract text is available yet for this article.
May 10, 2019: Annals of the Rheumatic Diseases
#18
LETTER
Xavier Bossuyt, Jolien Claessens, Ellen De Langhe, Thibaut Belmondo, Rene Westhovens, Sophie Hue, Koen Poesen, Daniel Blockmans, Michael Mahler, Marvin J Fritzler
No abstract text is available yet for this article.
May 10, 2019: Annals of the Rheumatic Diseases
#19
David S Pisetsky, Diane M Spencer, Peter E Lipsky, Brad H Rovin
No abstract text is available yet for this article.
May 10, 2019: Annals of the Rheumatic Diseases
#20
EDITORIAL
Isabelle Peene, Dirk Elewaut
No abstract text is available yet for this article.
May 10, 2019: Annals of the Rheumatic Diseases
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