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EDITORIAL
Salvatore Minisola, Jessica Pepe, Cristiana Cipriani
No abstract text is available yet for this article.
January 17, 2021: Annals of the Rheumatic Diseases
#2
Latanya N Coke, Hongxiu Wen, Mary Comeau, Mustafa H Ghanem, Andrew Shih, Christine N Metz, Wentian Li, Carl D Langefeld, Peter K Gregersen, Kim R Simpfendorfer
OBJECTIVES: To determine if the polymorphism encoding the Arg206Cys substitution in DNASE1L3 explains the association of the DNASE1L3 / PXK gene locus with systemic lupus erythematosus (SLE) and to examine the effect of the Arg206Cys sequence change on DNASE1L3 protein function. METHODS: Conditional analysis for rs35677470 was performed on cases and controls with European ancestry from the SLE Immunochip study, and genotype and haplotype frequencies were compared...
January 17, 2021: Annals of the Rheumatic Diseases
#3
Ketian Li, Wenxiu Mo, Lijun Wu, Xunyao Wu, Cainan Luo, Xinyue Xiao, Xinmiao Jia, Huaxia Yang, Yunyun Fei, Hua Chen, Fengchun Zhang, Yongzhe Li, Lidan Zhao, Xuan Zhang
OBJECTIVES: Lack of effective biomarkers in anti-citrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA) impedes early diagnosis and treatment. This study aimed to identify novel autoantibodies in RA and verify their diagnostic values in ACPA-negative RA based on protein microarray technology. METHODS: A total of 1011 sera from 559 RA (276 ACPA-positive and 283 ACPA-negative), 239 disease controls (DCs) and 213 healthy controls (HCs) were collected and sampled on two sequential microarrays and ELISA and western blot (WB) detection, for novel autoantibodies discovery, validation and verification, respectively...
January 15, 2021: Annals of the Rheumatic Diseases
#4
LETTER
Sarthak Gupta, Shuichiro Nakabo, Jun Chu, Sarfaraz Hasni, Mariana J Kaplan
No abstract text is available yet for this article.
January 15, 2021: Annals of the Rheumatic Diseases
#5
René Westhovens, William F C Rigby, Désirée van der Heijde, Daniel W T Ching, William Stohl, Jonathan Kay, Arvind Chopra, Beatrix Bartok, Franziska Matzkies, Zhaoyu Yin, Ying Guo, Chantal Tasset, John S Sundy, Angelika Jahreis, Neelufar Mozaffarian, Osvaldo Daniel Messina, Robert Bm Landewé, Tatsuya Atsumi, Gerd R Burmester
OBJECTIVES: To investigate efficacy and safety of the Janus kinase-1 inhibitor filgotinib in patients with active rheumatoid arthritis (RA) with limited or no prior methotrexate (MTX) exposure. METHODS: This 52-week, phase 3, multicentre, double-blind clinical trial (NCT02886728) evaluated once-daily oral filgotinib in 1252 patients with RA randomised 2:1:1:2 to filgotinib 200 mg with MTX (FIL200 +MTX), filgotinib 100 mg with MTX (FIL100 +MTX), filgotinib 200 mg monotherapy (FIL200), or MTX...
January 15, 2021: Annals of the Rheumatic Diseases
#6
Laura P Whittall Garcia, Dafna D Gladman, Murray Urowitz, Zahi Touma, Jiandong Su, Sindhu R Johnson
OBJECTIVE: To determine the ominosity of the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) Systemic Lupus Erythematosus Classification Criteria by determining its predictive role for disease severity in the first 5 years following diagnosis. METHODS: 867 patients with systemic lupus erythematosus (SLE) from the Toronto Lupus Clinic were included (all first 12 months after SLE diagnosis). The EULAR/ACR criteria score was calculated based on baseline information...
January 15, 2021: Annals of the Rheumatic Diseases
#7
LETTER
Haiyan Yang, Jie Xu, Li Shi, Guangcai Duan, Yadong Wang
No abstract text is available yet for this article.
January 15, 2021: Annals of the Rheumatic Diseases
#8
LETTER
Yijun You, Ce Shi, Zhuochao Zhou, Fan Wang, Yue Sun, Jialin Teng, Honglei Liu, Xiaobing Cheng, Yutong Su, Hui Shi, Chengde Yang, Junna Ye
No abstract text is available yet for this article.
January 15, 2021: Annals of the Rheumatic Diseases
#9
Shintaro Akiyama, Shadi Hamdeh, Dejan Micic, Atsushi Sakuraba
No abstract text is available yet for this article.
January 15, 2021: Annals of the Rheumatic Diseases
#10
Annemaria C van Berkel, Dieuwke Schiphof, Jan H Waarsing, Jos Runhaar, John M van Ochten, Patrick J E Bindels, Sita M A Bierma-Zeinstra
OBJECTIVE: To explore the natural course of hip osteoarthritis (OA) in a population of first-time presenters with hip complaints. METHODS: Data were collected at baseline and after 2, 5, 8 and 10 years on participants from the Cohort Hip and Cohort Knee study with early symptomatic hip OA. Descriptive statistics were used to analyse the natural course of the hip complaints with respect to clinical signs and symptoms, physical functioning and radiographic osteoarthritis (ROA) features...
January 15, 2021: Annals of the Rheumatic Diseases
#11
Iago Pinal-Fernandez, Maria Casal-Dominguez, Jose Cesar Milisenda, Andrew Lee Mammen
No abstract text is available yet for this article.
January 13, 2021: Annals of the Rheumatic Diseases
#12
LETTER
Elise van Mulligen, Annette van der Helm-van Mil, Pascal Hendrik Pieter de Jong
No abstract text is available yet for this article.
January 13, 2021: Annals of the Rheumatic Diseases
#13
LETTER
Irfan Mohammad, Phani Kumar Devarasetti, Liza Rajasekhar
No abstract text is available yet for this article.
January 13, 2021: Annals of the Rheumatic Diseases
#14
Ingrid E Lundberg, Frederick W Miller, Lisa G Rider, Victoria P Werth, Anna Tjärnlund, Matteo Bottai
No abstract text is available yet for this article.
January 13, 2021: Annals of the Rheumatic Diseases
#15
Xiao-Huan Chen, Fang-Xiao Zhu, Hsin-Hua Chen, James Cheng-Chung Wei
No abstract text is available yet for this article.
January 13, 2021: Annals of the Rheumatic Diseases
#16
LETTER
Kevin Sheng-Kai Ma, Cho-Han Chiang, Yi-Wen Chen, Li-Tzu Wang
No abstract text is available yet for this article.
January 12, 2021: Annals of the Rheumatic Diseases
#17
LETTER
Kristin M D'Silva, Naomi Serling-Boyd, Tiffany Y-T Hsu, Jeffrey A Sparks, Zachary S Wallace
No abstract text is available yet for this article.
January 12, 2021: Annals of the Rheumatic Diseases
#18
Irina Gessl, Mihaela Popescu, Victoria Schimpl, Gabriela Supp, Thomas Deimel, Martina Durechova, Miriam Hucke, Michaela Loiskandl, Paul Studenic, Michael Zauner, Josef S Smolen, Daniel Aletaha, Peter Mandl
OBJECTIVES: To determine whether clinical tenderness can be considered a sign of inflammatory joint activity in patients with rheumatoid arthritis (RA), osteoarthritis (OA) or psoriatic arthritis (PsA) and to assess other possible factors associated with tenderness. METHODS: Patients diagnosed with RA, PsA and OA underwent clinical and ultrasound examination of wrists and finger joints. Radiographs of the hands were scored for erosions, joint space narrowing (JSN), osteophytes and malalignment...
January 12, 2021: Annals of the Rheumatic Diseases
#19
Eunji Ha, So-Young Bang, Jiwoo Lim, Jun Ho Yun, Jeong-Min Kim, Jae-Bum Bae, Hye-Soon Lee, Bong-Jo Kim, Kwangwoo Kim, Sang-Cheol Bae
OBJECTIVE: CD4+ T cells have been suggested as the most disease-relevant cell type in rheumatoid arthritis (RA) in which RA-risk non-coding variants exhibit allele-specific effects on regulation of RA-driving genes. This study aimed to understand RA-specific signatures in CD4+ T cells using multi-omics data, interpreting inter-omics relationships in shaping the RA transcriptomic landscape. METHODS: We profiled genome-wide variants, gene expression and DNA methylation in CD4+ T cells from 82 patients with RA and 40 healthy controls using high-throughput technologies...
January 12, 2021: Annals of the Rheumatic Diseases
#20
LETTER
Cleo Rogier, Bastiaan T van Dijk, Elisabeth Brouwer, Pascal H P de Jong, Annette H M van der Helm-van Mil
No abstract text is available yet for this article.
January 7, 2021: Annals of the Rheumatic Diseases
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