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Ian J Wallace, David T Felson, Steven Worthington, Jeffrey Duryea, Margaret Clancy, Piran Aliabadi, Geeta N Eick, J Josh Snodgrass, Aaron L Baggish, Daniel E Lieberman
Non-industrial societies with low energy balance levels are expected to be less vulnerable than industrial societies to diseases associated with obesity including knee osteoarthritis. However, as non-industrial societies undergo rapid lifestyle changes that promote positive energy balance, individuals whose metabolisms are adapted to energetic scarcity are encountering greater energy abundance, increasing their propensity to accumulate abdominal adipose tissue and thus potentially their sensitivity to obesity-related diseases...
September 13, 2019: Annals of the Rheumatic Diseases
#2
LETTER
Bhaskar Dasgupta, Kate Smith, Abdullah Abu Syeed Khan, Fiona Coath, Richard J Wakefield
No abstract text is available yet for this article.
September 13, 2019: Annals of the Rheumatic Diseases
#3
Saeid Safiri, Ali Asghar Kolahi, Damian Hoy, Emma Smith, Deepti Bettampadi, Mohammad Ali Mansournia, Amir Almasi-Hashiani, Ahad Ashrafi-Asgarabad, Maziar Moradi-Lakeh, Mostafa Qorbani, Gary Collins, Anthony D Woolf, Lyn March, Marita Cross
OBJECTIVES: To provide the level and trends of prevalence, incidence and disability adjusted life years (DALYs) for rheumatoid arthritis (RA) in 195 countries from 1990 to 2017 by age, sex, Socio-demographic Index (SDI; a composite of sociodemographic factors) and Healthcare Access and Quality (an indicator of health system performance) Index. METHODS: Data from the Global Burden of Diseases, Injuries, and Risk Factors study (GBD) 2017 were used. GBD 2017 modelled the burden of RA for 195 countries from 1990 to 2017, through a systematic analysis of mortality and morbidity data to estimate prevalence, incidence and DALYs...
September 11, 2019: Annals of the Rheumatic Diseases
#4
LETTER
Florence Assan, Raphaele Seror, Xavier Mariette, Gaetane Nocturne
No abstract text is available yet for this article.
September 9, 2019: Annals of the Rheumatic Diseases
#5
David Bursill, William J Taylor, Robert Terkeltaub, Abhishek Abhishek, Alexander K So, Ana Beatriz Vargas-Santos, Angelo Lino Gaffo, Ann Rosenthal, Anne-Kathrin Tausche, Anthony Reginato, Bernhard Manger, Carlo Sciré, Carlos Pineda, Caroline van Durme, Ching-Tsai Lin, Congcong Yin, Daniel Arthur Albert, Edyta Biernat-Kaluza, Edward Roddy, Eliseo Pascual, Fabio Becce, Fernando Perez-Ruiz, Francisca Sivera, Frédéric Lioté, Georg Schett, George Nuki, Georgios Filippou, Geraldine McCarthy, Geraldo da Rocha Castelar Pinheiro, Hang-Korng Ea, Helena De Almeida Tupinambá, Hisashi Yamanaka, Hyon K Choi, James Mackay, James R ODell, Janitzia Vázquez Mellado, Jasvinder A Singh, John D Fitzgerald, Lennart T H Jacobsson, Leo Joosten, Leslie R Harrold, Lisa Stamp, Mariano Andrés, Marwin Gutierrez, Masanari Kuwabara, Mats Dehlin, Matthijs Janssen, Michael Doherty, Michael S Hershfield, Michael Pillinger, N Lawrence Edwards, Naomi Schlesinger, Nitin Kumar, Ole Slot, Sebastien Ottaviani, Pascal Richette, Paul A MacMullan, Peter T Chapman, Peter E Lipsky, Philip Robinson, Puja P Khanna, Rada N Gancheva, Rebecca Grainger, Richard J Johnson, Ritch Te Kampe, Robert T Keenan, Sara K Tedeschi, Seoyoung Kim, Sung Jae Choi, Theodore R Fields, Thomas Bardin, Till Uhlig, Tim Jansen, Tony Merriman, Tristan Pascart, Tuhina Neogi, Viola Klück, Worawit Louthrenoo, Nicola Dalbeth
OBJECTIVE: There is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout. METHODS: A content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels and definitions...
September 9, 2019: Annals of the Rheumatic Diseases
#6
LETTER
Kuan-Fu Liao, Yu-Hung Kuo, Shih-Wei Lai
No abstract text is available yet for this article.
September 6, 2019: Annals of the Rheumatic Diseases
#7
LETTER
Maria Infantino, Mariangela Manfredi, Nicola Bizzaro
No abstract text is available yet for this article.
September 6, 2019: Annals of the Rheumatic Diseases
#8
Charlotte Eijkelboom, Nienke M Ter Haar, Joost Frenkel, Marco Gattorno
No abstract text is available yet for this article.
September 6, 2019: Annals of the Rheumatic Diseases
#9
LETTER
Nupoor Acharya, Arghya Chattopadhyay, Varun Dhir
No abstract text is available yet for this article.
September 6, 2019: Annals of the Rheumatic Diseases
#10
Bernard J Fox, Jason Hockley, Peter Rigsby, Carl Dolman, Pier Luigi Meroni, Johan Rönnelid
INTRODUCTION: Antibodies against double-stranded DNA (anti-dsDNA) are a specific biomarker for systemic lupus erythematosus (SLE). The first WHO International Standard (IS) for anti-dsDNA (established in 1985), which was used to assign units to diagnostic tests, was exhausted over a decade ago. METHODS: Plasma from a patient with SLE was first evaluated in 42 European laboratories. The plasma was thereafter used by the National Institute for Biological Standards and Control to prepare a candidate WHO reference preparation for lupus (anti-dsDNA) antibodies...
September 5, 2019: Annals of the Rheumatic Diseases
#11
Meng Sun, Bence Rethi, Akilan Krishnamurthy, Vijay Joshua, Alexandra Circiumaru, Aase Haj Hensvold, Elena Ossipova, Caroline Grönwall, Yanying Liu, Marianne Engstrom, Sergiu Bogdan Catrina, Johanna Steen, Vivianne Malmstrom, Lars Klareskog, Camilla Svensson, Caroline Ospelt, Heidi Wähämaa, Anca Irinel Catrina
OBJECTIVES: Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) might contribute to bone loss and arthralgia before the onset of joint inflammation. We aimed to dissect additional mechanisms by which ACPAs might contribute to development of joint pathology. METHODS: Fibroblast-like synoviocytes (FLS) were isolated from the synovial membrane of patients with RA. The FLS cultures were stimulated with polyclonal ACPAs (anti-CCP-2 antibodies) purified from the peripheral blood of patients with RA or with monoclonal ACPAs derived from single synovial fluid B cells...
September 3, 2019: Annals of the Rheumatic Diseases
#12
Laurence Fardet, Irene Petersen, Irwin Nazareth
No abstract text is available yet for this article.
August 31, 2019: Annals of the Rheumatic Diseases
#13
Zoya Qaiyum, Eric Gracey, YuChen Yao, Robert D Inman
OBJECTIVES: Current evidence suggests that immune events in the gut may impact joint inflammation in ankylosing spondylitis (AS) but the expression of gut-related trafficking molecules in the inflammed joint is poorly characterised. We aimed to (1) assess differential expression patterns of trafficking molecules between patients and controls, (2) generate joint-specific cellular signatures and (3) obtain transcriptomic profiles of noteworthy cell subpopulations. METHODS: Male subjects under 40 years of age fulfilling the mNY criteria were recruited...
August 30, 2019: Annals of the Rheumatic Diseases
#14
Theresa Kissel, Karin Anna van Schie, Lise Hafkenscheid, Anders Lundquist, Heidi Kokkonen, Manfred Wuhrer, Tom Wj Huizinga, Hans Ulrich Scherer, René Toes, Solbritt Rantapää-Dahlqvist
OBJECTIVE: Anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) patients display a unique feature defined by the abundant presence of N -linked glycans within the variable domains (V-domains). Recently, we showed that N -glycosylation sites, which are required for the incorporation of V-domain glycans, are introduced following somatic hypermutation. However, it is currently unclear when V-domain glycosylation occurs. Further, it is unknown which factors might trigger the generation of V-domain glycans and whether such glycans are relevant for the transition towards RA...
August 30, 2019: Annals of the Rheumatic Diseases
#15
María Camacho-Encina, Vanesa Balboa-Barreiro, Ignacio Rego-Perez, Florencia Picchi, Jennifer VanDuin, Ji Qiu, Manuel Fuentes, Natividad Oreiro, Joshua LaBaer, Cristina Ruiz-Romero, Francisco J Blanco
OBJECTIVE: To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA). DESIGN: A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was used to screen AAbs against 2125 human proteins in sera at baseline from participants free of radiographic KOA belonging to the incidence and non-exposed subcohorts of the Osteoarthritis Initiative (OAI) who developed or not, radiographic KOA during a follow-up period of 96 months...
August 30, 2019: Annals of the Rheumatic Diseases
#16
LETTER
Zhiqiang Li, Hong-Lei Liu, Jianhua Chen, Ting Zeng, Lin He, Meihang Li, Cainan Luo, Shuang Liu, Ting-Ting Ding, Kuerbanjiang Yimaiti, Jialin Teng, Xingwang Li, Yonghe Ding, Xiaobing Cheng, Juan Zhou, Junna Ye, Jue Ji, Yu-Tong Su, Hui Shi, Yue Sun, Chengwen Gao, Qiongyi Hu, Huihui Chi, Xuan Yuan, Zhuochao Zhou, Dong Wang, Ke Wang, Chang-Gui Li, Yuanchao Sun, Yujuan Niu, Lin-Jie Chen, Jian Xu, Lijun Wu, Zhaowei Zhou, Dun Pan, Haitao Niu, Yongyong Shi, Chengde Yang
No abstract text is available yet for this article.
August 30, 2019: Annals of the Rheumatic Diseases
#17
Guanhua Song, Tingting Feng, Ru Zhao, Qiqi Lu, Yutao Diao, Qingwei Guo, Zhaoxia Wang, Yuang Zhang, Luna Ge, Jihong Pan, Lin Wang, Jinxiang Han
OBJECTIVE: The aim of this study was to investigate the role of CD109 in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) and to evaluate its potential as a therapeutic target. METHODS: CD109 expression was examined in synovial tissues and FLSs from RA patients and collagen-induced arthritis (CIA) model mice. CD109-deficient mice were developed to evaluate the severity of CIA. Small interfering RNAs and a neutralising antibody against CD109 (anti-CD109) were designed for functional or treatment studies in RA FLSs and CIA...
August 27, 2019: Annals of the Rheumatic Diseases
#18
LETTER
Jean Jacques Dubost, Bruno Pereira, Angelique Fan, Martin Soubrier
No abstract text is available yet for this article.
August 27, 2019: Annals of the Rheumatic Diseases
#19
LETTER
Latika Gupta, Sakir Ahmed, Bharati Singh, Satya Prakash, Shubha Phadke, Amita Aggarwal
No abstract text is available yet for this article.
August 24, 2019: Annals of the Rheumatic Diseases
#20
Minghua Wu, Brian Skaug, Xiongjie Bi, Tingting Mills, Gloria Salazar, Xiaodong Zhou, John Reveille, Sandeep K Agarwal, Michael R Blackburn, Maureen D Mayes, Shervin Assassi
OBJECTIVES: There is considerable evidence that implicates dysregulation of type I interferon signalling (or type I IFN signature) in the pathogenesis of systemic sclerosis (SSc). Interferon regulatory factor 7 (IRF7) has been recognised as a master regulator of type I IFN signalling. The objective of this study was to elucidate the role of IRF7 in dermal fibrosis and SSc pathogenesis. METHODS: SSc and healthy control skin biopsies were investigated to determine IRF7 expression and activation...
August 22, 2019: Annals of the Rheumatic Diseases
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