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Annals of the Rheumatic Diseases

Mirko Manetti
No abstract text is available yet for this article.
March 13, 2019: Annals of the Rheumatic Diseases
Jan Damoiseaux, Luis Eduardo Coelho Andrade, Orlando Gabriel Carballo, Karsten Conrad, Paulo Luiz Carvalho Francescantonio, Marvin J Fritzler, Ignacio Garcia de la Torre, Manfred Herold, Werner Klotz, Wilson de Melo Cruvinel, Tsuneyo Mimori, Carlos von Muhlen, Minoru Satoh, Edward K Chan
The indirect immunofluorescence assay (IIFA) on HEp-2 cells is widely used for detection of antinuclear antibodies (ANA). The dichotomous outcome, negative or positive, is integrated in diagnostic and classification criteria for several systemic autoimmune diseases. However, the HEp-2 IIFA test has much more to offer: besides the titre or fluorescence intensity, it also provides fluorescence pattern(s). The latter include the nucleus and the cytoplasm of interphase cells as well as patterns associated with mitotic cells...
March 12, 2019: Annals of the Rheumatic Diseases
Isabell S von Loga, Aadil El-Turabi, Luke Jostins, Jadwiga Miotla-Zarebska, Jennifer Mackay-Alderson, Andris Zeltins, Ida Parisi, Martin F Bachmann, Tonia L Vincent
OBJECTIVES: Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis (OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a novel vaccine strategy to generate anti-NGF antibodies for reversal of pain behaviour in a surgical model of OA. METHODS: Virus-like particles were derived from the cucumber mosaic virus (CuMV) and coupled to expressed recombinant NGF to create the vaccine. 10-week-old male mice underwent partial meniscectomy to induce OA or sham-surgery...
March 12, 2019: Annals of the Rheumatic Diseases
Erika Van Nieuwenhove, Vasiliki Lagou, Lien Van Eyck, James Dooley, Ulrich Bodenhofer, Carlos Roca, Marijne Vandebergh, An Goris, Stéphanie Humblet-Baron, Carine Wouters, Adrian Liston
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is the most common class of childhood rheumatic diseases, with distinct disease subsets that may have diverging pathophysiological origins. Both adaptive and innate immune processes have been proposed as primary drivers, which may account for the observed clinical heterogeneity, but few high-depth studies have been performed. METHODS: Here we profiled the adaptive immune system of 85 patients with JIA and 43 age-matched controls with indepth flow cytometry and machine learning approaches...
March 12, 2019: Annals of the Rheumatic Diseases
Wanlong Wu, Suzana Jordan, Nicole Graf, Janethe de Oliveira Pena, John Curram, Yannick Allanore, Marco Matucci-Cerinic, Janet E Pope, Christopher P Denton, Dinesh Khanna, Oliver Distler
OBJECTIVES: To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients with diffuse cutaneous systemic sclerosis (dcSSc). METHODS: We evaluated patients from the European Scleroderma Trials and Research database with dcSSc, baseline modified Rodnan skin score (mRSS) ≥7, valid mRSS at 12±3 months after baseline and ≥1 annual follow-up visit. Progressive skin fibrosis was defined as an increase in mRSS >5 and ≥25% from baseline to 12±3 months...
March 9, 2019: Annals of the Rheumatic Diseases
Graham Fent, Kulveer Mankia, Bara Erhayiem, Laura Hunt, Jacqueline Leong Nam, Lesley-Anne Bissell, James Rj Foley, Pei G Chew, Louise E Brown, John P Greenwood, Paul Emery, Sven Plein, Maya H Buch
No abstract text is available yet for this article.
March 9, 2019: Annals of the Rheumatic Diseases
Alexandru Dregan, Faith Matcham, Lisa Harber-Aschan, Lauren Rayner, Anamaria Brailean, Katrina Davis, Stephani Hatch, Carmine Pariante, David Armstrong, Robert Stewart, Matthew Hotopf
OBJECTIVE: There is inconsistent evidence about the association between inflammatory disorders and depression and anxiety onset in a primary care context. The study aimed to evaluate the risk of depression and anxiety within multisystem and organ-specific inflammatory disorders. METHODS: This is a prospective cohort study with primary care patients from the UK Clinical Practice Research Datalink diagnosed with an inflammatory disorder between 1 January 2001 and 31 December 2016...
March 7, 2019: Annals of the Rheumatic Diseases
Mehmet Eyuboglu
No abstract text is available yet for this article.
March 6, 2019: Annals of the Rheumatic Diseases
Kazuhiko Yamamoto, Yukinori Okada
No abstract text is available yet for this article.
March 6, 2019: Annals of the Rheumatic Diseases
Bernard Combe, Alejandro Balsa, Piercarlo Sarzi-Puttini, Hans-Peter Tony, Inmaculada de la Torre, Veronica Rogai, Frederick Durand, Sarah Witt, Jinglin Zhong, Maxime Dougados
No abstract text is available yet for this article.
March 6, 2019: Annals of the Rheumatic Diseases
Lan Zhao, Jian Huang, Yunshan Fan, Jun Li, Tianming You, Shisheng He, Guozhi Xiao, Di Chen
OBJECTIVES: Osteoarthritis (OA) is a painful and debilitating disease and it is associated with aberrant upregulation of multiple factors, including matrix metalloproteinase 13 (MMP13), interleukin-1β (IL-1β) and nerve growth factor (NGF). In this study, we aimed to use the CRISPR/Cas9 technology, a highly efficient gene-editing tool, to study whether the ablation of OA-associated genes has OA-modifying effects. METHODS: We performed intra-articular injection of adeno-associated virus, which expressed CRISPR/Cas9 components to target each of the genes encoding MMP13, IL-1β and NGF, in a surgically induced OA mouse model...
March 6, 2019: Annals of the Rheumatic Diseases
Francesco Zulian, Roberta Culpo, Francesca Sperotto, Jordi Anton, Tadej Avcin, Eileen M Baildam, Christina Boros, Jeffrey Chaitow, Tamàs Constantin, Ozgur Kasapcopur, Sheila Knupp Feitosa de Oliveira, Clarissa A Pilkington, Ricardo Russo, Natasa Toplak, Annet van Royen, Claudia Saad Magalhães, Sebastiaan J Vastert, Nico M Wulffraat, Ivan Foeldvari
In 2012, a European initiative called Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile localised scleroderma (JLS) is a rare disease within the group of paediatric rheumatic diseases (PRD) and can lead to significant morbidity. Evidence-based guidelines are sparse and management is mostly based on physicians' experience. This study aims to provide recommendations for assessment and treatment of JLS...
March 2, 2019: Annals of the Rheumatic Diseases
Thomas Dörner, Maximilian Georg Posch, Yue Li, Olivier Petricoul, Maciej Cabanski, Julie Marie Milojevic, Esther Kamphausen, Marie-Anne Valentin, Claudia Simonett, Louise Mooney, Andreas Hüser, Hermann Gram, Frank Dietrich Wagner, Stephen John Oliver
OBJECTIVES: To evaluate the efficacy and safety of ianalumab (VAY736), a B cell-depleting, B cell activating factor receptor-blocking, monoclonal antibody, in patients with active primary Sjögren's syndrome (pSS) in a double-blind, placebo-controlled, phase II, single-centre study. METHODS: Patients with pSS, EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) ≥6, were randomised to ianalumab single infusion at either 3 mg/kg (n=6), 10 mg/kg (n=12) or placebo (n=9)...
March 2, 2019: Annals of the Rheumatic Diseases
Nadia Vazirpanah, Andrea Ottria, Maarten van der Linden, Catharina G K Wichers, Mark Schuiveling, Ellen van Lochem, Amanda Phipps-Green, Tony Merriman, Maili Zimmermann, Matthijs Jansen, Timothy R D J Radstake, Jasper C A Broen
OBJECTIVE: Gout is the most common inflammatory arthritis worldwide, and patients experience a heavy burden of cardiovascular and metabolic diseases. The inflammation is caused by the deposition of monosodium urate (MSU) crystals in tissues, especially in the joints, triggering immune cells to mount an inflammatory reaction. Recently, it was shown that MSU crystals can induce mechanistic target of rapamycin (mTOR) signalling in monocytes encountering these crystals in vitro. The mTOR pathway is strongly implicated in cardiovascular and metabolic disease...
February 27, 2019: Annals of the Rheumatic Diseases
Leonieke J J van Mens, Henriëtte M de Jong, Inka Fluri, Michael T Nurmohamed, Marleen G H van de Sande, Marc Kok, Arno W R van Kuijk, Dominique Baeten
OBJECTIVES: Early initiation of effective treatment favours remission in rheumatoid arthritis, but it remains unknown if the same concept applies to psoriatic arthritis (PsA). Therefore, this study investigated whether the combination of golimumab plus methotrexate (MTX) as a first-line treatment is superior to MTX alone in inducing remission in PsA. METHODS: This investigator-initiated, multicentre, double-blind, randomised, placebo-controlled trial included 51 MTX and bDMARD-naive patients with PsA fulfilling the CASPAR criteria and with active disease at baseline (≥3 swollen joint count/tender joint count)...
February 26, 2019: Annals of the Rheumatic Diseases
Angel Bottini, Dennis J Wu, Rizi Ai, Michelle Le Roux, Beatrix Bartok, Michele Bombardieri, Karen M Doody, Vida Zhang, Cristiano Sacchetti, Martina Zoccheddu, Ana Lonic, Xiaochun Li, David L Boyle, Deepa Hammaker, Tzu-Ching Meng, Lin Liu, Maripat Corr, Stephanie M Stanford, Myles Lewis, Wei Wang, Gary S Firestein, Yeesim Khew-Goodall, Costantino Pitzalis, Nunzio Bottini
OBJECTIVE: We aimed to understand the role of the tyrosine phosphatase PTPN14-which in cancer cells modulates the Hippo pathway by retaining YAP in the cytosol-in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). METHODS: Gene/protein expression levels were measured by quantitative PCR and/or Western blotting. Gene knockdown in RA FLS was achieved using antisense oligonucleotides. The interaction between PTPN14 and YAP was assessed by immunoprecipitation...
February 26, 2019: Annals of the Rheumatic Diseases
Pomme Bm Poppelaars, Lilian H D van Tuyl, Maarten Boers
OBJECTIVES: Mortality in patients with rheumatoid arthritis (RA) is higher than in the general population. We investigated mortality in the COBRA-trial cohort after 23 years follow-up, compared with a reference sample of the Dutch population. METHODS: The COBRA-trial randomised patients with early RA to sulfasalazine monotherapy (SSZ, n=79) or a combination of SSZ, low-dose methotrexate and initially high, step-down prednisolone (COBRA, n=76). We compared the mortality in the COBRA-trial up to 2017 to a reference sample of the general population in the Netherlands (standardised mortality ratio, SMR), and its relation to early prognostic factors through stepwise Cox regression...
February 26, 2019: Annals of the Rheumatic Diseases
Johannes Mofors, Håkan Eliasson, Aurelie Ambrosi, Stina Salomonsson, Amanda Skog, Michael Fored, Anders Ekbom, Gunnar Bergman, Sven-Erik Sonesson, Marie Wahren-Herlenius
OBJECTIVE: Congenital heart block (CHB) may develop in fetuses of Ro/SSA autoantibody-positive women. Given the rarity of CHB, information on comorbidity and complications later in life is difficult to systematically collect for large groups of patients. We therefore used nation-wide healthcare registers to investigate comorbidity and outcomes in patients with CHB and their siblings. METHODS: Data from patients with CHB (n= 119) and their siblings (n= 128), all born to anti-Ro/SSA-positive mothers, and from matched healthy controls (n= 1,190) and their siblings (n= 1,071), were retrieved from the Swedish National Patient Register...
February 26, 2019: Annals of the Rheumatic Diseases
Helga Westerlind, Marie Holmqvist, Lotta Ljung, Thomas Frisell, Johan Askling
OBJECTIVES: To investigate a potential shared susceptibility between rheumatoid arthritis (RA) and acute coronary syndrome (ACS) by estimation of the risk of ACS among full siblings of patients with RA. METHODS: By linking nation-wide Swedish registers, we identified a cohort of patients with new-onset RA 1996-2016, age- and sex-matched (5:1) general population comparator subjects, full siblings of RA and comparator subjects, and incident ACS events through 31 December 2016...
February 20, 2019: Annals of the Rheumatic Diseases
Giovanni Adami, Angelo Fassio, Giovanni Orsolini, Alessandro Giollo, Davide Gatti, Maurizio Rossini
No abstract text is available yet for this article.
February 20, 2019: Annals of the Rheumatic Diseases
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