journal
https://read.qxmd.com/read/38754983/single-cell-transcriptomes-and-chromatin-accessibility-of-endothelial-cells-unravel-transcription-factors-associated-with-dysregulated-angiogenesis-in-systemic-sclerosis
#1
JOURNAL ARTICLE
Mengqi Huang, Tracy Tabib, Dinesh Khanna, Shervin Assassi, Robyn Domsic, Robert Lafyatis
OBJECTIVES: Vasculopathy emerges early in systemic sclerosis (SSc) and links to endothelial cell (EC) injury and angiogenesis. Understanding EC transcriptomes and epigenomes is crucial for unravelling the mechanisms involved. METHODS: Transcriptomes and chromatin accessibility were assessed by single-cell RNA sequencing and single-nucleus transposase-accessible chromatin sequencing. Immunofluorescent staining of skin and proteomics assay were employed to confirm the altered SSc EC phenotypes...
May 16, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38754982/treatment-of-recalcitrant-psoriasis-and-psoriatic-arthritis-with-a-combination-of-a-biologic-plus-an-oral-jak-or-tyk2-inhibitor-a-case-series
#2
LETTER
M Grace Hren, Saakshi Khattri
No abstract text is available yet for this article.
May 16, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38754981/remission-and-low-disease-activity-are-associated-with-lower-healthcare-costs-results-from-the-systemic-lupus-international-collaborating-clinics-slicc-inception-cohort
#3
JOURNAL ARTICLE
Megan R W Barber, Manuel Francisco Ugarte-Gil, John G Hanly, Murray B Urowitz, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J Wallace, David A Isenberg, Anisur Rahman, Joan T Merrill, Paul R Fortin, Dafna D Gladman, Ian N Bruce, Michelle Petri, Ellen M Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jönsen, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, S Sam Lim, Murat Inanc, Kenneth C Kalunian, Søren Jacobsen, Christine A Peschken, Diane L Kamen, Anca Askanase, Bernardo A Pons-Estel, Francesca S Cardwell, Graciela S Alarcón, Ann E Clarke
OBJECTIVES: This study aims to determine the independent impact of definitions of remission/low disease activity (LDA) on direct/indirect costs (DCs, ICs) in a multicentre inception cohort. METHODS: Patients from 31 centres in 10 countries were enrolled within 15 months of diagnosis and assessed annually. Five mutually exclusive disease activity states (DAS) were defined as (1) remission off-treatment: clinical (c) SLEDAI-2K=0, without prednisone/immunosuppressants; (2) remission on-treatment: cSLEDAI-2K=0, prednisone ≤5 mg/day and/or maintenance immunosuppressants; (3) LDA-Toronto Cohort (TC): cSLEDAI-2K≤2, without prednisone/immunosuppressants; (4) modified lupus LDA state (mLLDAS): SLEDAI-2K≤4, no activity in major organs/systems, no new activity, prednisone ≤7...
May 16, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38749573/the-role-of-dna-in-the-pathogenesis-of-sle-dna-as-a-molecular-chameleon
#4
REVIEW
David S Pisetsky, Alan Herbert
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by antibodies to DNA (anti-DNA) and other nuclear macromolecules. Anti-DNA antibodies are markers for classification and disease activity and promote pathogenesis by forming immune complexes that deposit in the tissue or stimulate cytokine production. Studies on the antibody response to DNA have focused primarily on a conformation of DNA known as B-DNA, the classic right-handed double helix. Among other conformations of DNA, Z-DNA is a left-handed helix with a zig-zag backbone; hence, the term Z-DNA...
May 15, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38749572/gout-risk-in-adults-with-pre-diabetes-initiating-metformin
#5
JOURNAL ARTICLE
Javier Marrugo, Leah M Santacroce, Misti L Paudel, Sho Fukui, Alexander Turchin, Sara K Tedeschi, Daniel H Solomon
OBJECTIVE: Despite the strong association between gout and pre-diabetes, the role of metformin in gout among individuals with pre-diabetes remains uncertain. We compared the incidence rates of gout in adults with pre-diabetes starting metformin with those not using antidiabetic treatments. METHODS: We conducted a new-user, propensity score-matched cohort study using electronic health records from an academic health system (2007-2022). Pre-diabetes was defined based on haemoglobin A1c levels...
May 15, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38740438/blood-rna-sequencing-across-the-continuum-of-ana-positive-autoimmunity-reveals-insights-into-initiating-immunopathology
#6
JOURNAL ARTICLE
Lucy Marie Carter, Md Yuzaiful Md Yusof, Zoe Wigston, Darren Plant, Stephanie Wenlock, Adewonuola Alase, Antonios Psarras, Edward M Vital
OBJECTIVE: Mechanisms underpinning clinical evolution to systemic lupus erythematosus (SLE) from preceding antinuclear antibodies (ANA) positivity are poorly understood. This study aimed to understand blood immune cell transcriptional signatures associated with subclinical ANA positivity, and progression or non-progression to SLE. METHODS: Bulk RNA-sequencing of peripheral blood mononuclear cells isolated at baseline from 35 ANA positive (ANA+) subjects with non-diagnostic symptoms was analysed using differential gene expression, weighted gene co-expression network analysis, deconvolution of cell subsets and functional enrichment analyses...
May 13, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38740437/kauko-vainio-1913-1989-pioneer-of-rheumaorthopaedic-surgery
#7
JOURNAL ARTICLE
Janis Timsans, Raine Tiihonen, Markku Kauppi
No abstract text is available yet for this article.
May 13, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38724076/patient-research-partner-involvement-in-rheumatology-research-a-systematic-literature-review-informing-the-2023-updated-eular-recommendations-for-the-involvement-of-patient-research-partners
#8
JOURNAL ARTICLE
Krystel Aouad, Maarten de Wit, Muriel Elhai, Diego Benavent, Heidi Bertheussen, Condruta Zabalan, Jette Primdahl, Paul Studenic, Laure Gossec
BACKGROUND: Patient research partners (PRPs) are people with a disease who collaborate in a research team as partners. The aim of this systematic literature review (SLR) was to assess barriers and facilitators to PRP involvement in rheumatology research. METHODS: The SLR was conducted in PubMed/Medline for articles on PRP involvement in rheumatology research, published between 2017 and 2023; websites were also searched in rheumatology and other specialties. Data were extracted regarding the definition of PRPs, their role and added value, as well as barriers and facilitators to PRP involvement...
May 8, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38724075/nat10-promotes-synovial-aggression-by-increasing-the-stability-and-translation-of-n4-acetylated-ptx3-mrna-in-rheumatoid-arthritis
#9
JOURNAL ARTICLE
Di Liu, Yu Kuang, Simin Chen, Ruiru Li, Fan Su, Shuoyang Zhang, Qian Qiu, Shuibin Lin, Chuyu Shen, Yingli Liu, Liuqin Liang, Jingnan Wang, Hanshi Xu, Youjun Xiao
OBJECTIVE: Recent studies indicate that N-acetyltransferase 10 (NAT10)-mediated ac4C modification plays unique roles in tumour metastasis and immune infiltration. This study aimed to uncover the role of NAT10-mediated ac4C in fibroblast-like synoviocytes (FLSs) functions and synovial immune cell infiltration in rheumatoid arthritis (RA). METHODS: FLSs were obtained from active established patients with RA. Protein expression was determined by western blotting or immunohistochemistry or multiplexed immunohistochemistry...
May 8, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38724074/adjustment-of-p-values-for-multiple-hypotheses-why-when-and-how
#10
JOURNAL ARTICLE
Stian Lydersen
It is quite common to investigate multiple hypotheses in a single study. For example, a researcher may want to investigate the effect on several outcome variables or at different time points, compare more than two groups or undertake separate analyses for subgroups. This increases the probability of type I errors. Different procedures for multiplicity adjustment are available to control the probability of type I errors. In the present article, we describe some methods for multiplicity adjustment, along with recommendations...
May 8, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38724073/identifying-the-association-between-serum-urate-levels-and-gout-flares-in-patients-taking-urate-lowering-therapy-a-post-hoc-cohort-analysis-of-the-cares-trial-with-consideration-of-dropout
#11
JOURNAL ARTICLE
Sara K Tedeschi, Keigo Hayashi, Yuqing Zhang, Hyon Choi, Daniel H Solomon
OBJECTIVE: To investigate gout flare rates based on repeated serum urate (SU) measurements in a randomised controlled trial of urate-lowering therapy (ULT), accounting for dropout and death. METHODS: We performed a secondary analysis using data from Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout, which randomised participants to febuxostat or allopurinol, titrated to target SU <6 mg/dL with flare prophylaxis for 6 months. SU was categorised as ≤3...
May 8, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38719588/philip-s-hench-and-the-discovery-of-cortisone
#12
JOURNAL ARTICLE
Eric L Matteson, Gene Hunder
No abstract text is available yet for this article.
May 7, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38702177/inflammatory-tissue-priming-novel-insights-and-therapeutic-opportunities-for-inflammatory-rheumatic-diseases
#13
REVIEW
Markus H Hoffmann, Henriette Kirchner, Gerhard Krönke, Gabriela Riemekasten, Michael Bonelli
Due to optimised treatment strategies and the availability of new therapies during the last decades, formerly devastating chronic inflammatory diseases such as rheumatoid arthritis or systemic sclerosis (SSc) have become less menacing. However, in many patients, even state-of-the-art treatment cannot induce remission. Moreover, the risk for flares strongly increases once anti-inflammatory therapy is tapered or withdrawn, suggesting that underlying pathological processes remain active even in the absence of overt inflammation...
May 3, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38702176/novel-autoantibodies-help-diagnose-anti-ssa-antibody-negative-sj%C3%A3-gren-disease-and-predict-abnormal-labial-salivary-gland-pathology
#14
JOURNAL ARTICLE
Maxwell Parker, Zihao Zheng, Michael R Lasarev, Michele C Larsen, Addie Vande Loo, Roxana A Alexandridis, Michael A Newton, Miriam A Shelef, Sara S McCoy
OBJECTIVES: Sjögren disease (SjD) diagnosis often requires either positive anti-SSA antibodies or a labial salivary gland biopsy with a positive focus score (FS). One-third of patients with SjD lack anti-SSA antibodies (SSA-), requiring a positive FS for diagnosis. Our objective was to identify novel autoantibodies to diagnose 'seronegative' SjD. METHODS: IgG binding to a high-density whole human peptidome array was quantified using sera from SSA- SjD cases and matched non-autoimmune controls...
May 3, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38702175/systematic-literature-review-to-inform-the-eular-recommendations-for-the-use-of-imaging-in-crystal-induced-arthropathies-in-clinical-practice
#15
JOURNAL ARTICLE
Irina Gessl, Garifallia Sakellariou, Brigitte Wildner, Georgios Filippou, Peter Mandl, Maria Antonietta D'Agostino, Victoria Navarro-Compán
OBJECTIVE: To summarise current data regarding the use of imaging in crystal-induced arthropathies (CiAs) informing a European Alliance of Associations for Rheumatology task force. METHODS: We performed four systematic searches in Embase, Medline and Central on imaging for diagnosis, monitoring, prediction of disease severity/treatment response, guiding procedures and patient education in gout, calcium pyrophosphate dihydrate deposition (CPPD) and basic calcium phosphate deposition (BCPD)...
May 3, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38569851/type-i-interferon-blockade-with-anifrolumab-in-patients-with-systemic-lupus-erythematosus-modulates-key-immunopathological-pathways-in-a-gene-expression-and-proteomic-analysis-of-two-phase-3-trials
#16
JOURNAL ARTICLE
Tina Baker, Hoda Sharifian, Paul J Newcombe, Patrick G Gavin, Mark N Lazarus, Madhu Ramaswamy, Wendy I White, Nicola Ferrari, Daniel Muthas, Raj Tummala, Eric F Morand, Richard Furie, Edward M Vital, Chris Chamberlain, Adam Platt, Hussein Al-Mossawi, Philip Z Brohawn, Eszter Csomor
INTRODUCTION: Anifrolumab is a type I interferon (IFN) receptor 1 (IFNAR1) blocking antibody approved for treating patients with systemic lupus erythematosus (SLE). Here, we investigated the immunomodulatory mechanisms of anifrolumab using longitudinal transcriptomic and proteomic analyses of the 52-week, randomised, phase 3 TULIP-1 and TULIP-2 trials. METHODS: Patients with moderate to severe SLE were enrolled in TULIP-1 and TULIP-2 and received intravenous anifrolumab or placebo alongside standard therapy...
May 3, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38688699/is-tooth-extraction-as-proxy-for-periodontal-disease-related-to-the-development-of-ra-lessons-from-a-longitudinal-study-in-the-at-risk-stage-of-clinically-suspect-arthralgia
#17
LETTER
Sarah J H Khidir, René E M Toes, Elise van Mulligen, Annette H M van der Helm-van Mil
No abstract text is available yet for this article.
April 30, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38684324/identification-and-validation-of-anti-protein-arginine-methyltransferase-5-prmt5-antibody-as-a-novel-biomarker-for-systemic-sclerosis-ssc
#18
JOURNAL ARTICLE
Minrui Liang, Lingbiao Wang, Xiaolong Tian, Kun Wang, Xiaoyi Zhu, Linlin Huang, Qing Li, Wenjing Ye, Chen Chen, Haihua Yang, Wanqing Wu, Xiangjun Chen, Xiaoxia Zhu, Yu Xue, Weiguo Wan, Yanling Wu, Liwei Lu, Jiucun Wang, Hejian Zou, Tianlei Ying, Feng Zhou
OBJECTIVES: In the complex panorama of autoimmune diseases, the characterisation of pivotal contributing autoantibodies that are involved in disease progression remains challenging. This study aimed to employ a global antibody profiling strategy to identify novel antibodies and investigate their association with systemic sclerosis (SSc). METHODS: We implemented this strategy by conducting immunoprecipitation (IP) following on-bead digestion with the sera of patients with SSc or healthy donors, using antigen pools derived from cell lysates...
April 29, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38684323/vascular-disease-persistence-in-giant-cell-arteritis-are-stromal-cells-neglected
#19
REVIEW
Maira Karabayas, Hafeez E Ibrahim, Anke J Roelofs, Gary Reynolds, Dana Kidder, Cosimo De Bari
Giant cell arteritis (GCA), the most common systemic vasculitis, is characterised by aberrant interactions between infiltrating and resident cells of the vessel wall. Ageing and breach of tolerance are prerequisites for GCA development, resulting in dendritic and T-cell dysfunction. Inflammatory cytokines polarise T-cells, activate resident macrophages and synergistically enhance vascular inflammation, providing a loop of autoreactivity. These events originate in the adventitia, commonly regarded as the biological epicentre of the vessel wall, with additional recruitment of cells that infiltrate and migrate towards the intima...
April 29, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38653532/no-sign-of-elevated-cardiovascular-risk-in-patients-with-seropositive-rheumatoid-arthritis-who-remain-on-stable-antirheumatic-therapy-results-from-the-nationwide-norwegian-cardio-rheuma-register
#20
LETTER
Eirik Ikdahl, Anne Grete Semb, Anne M Kerola
No abstract text is available yet for this article.
April 23, 2024: Annals of the Rheumatic Diseases
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