journal
https://read.qxmd.com/read/34321218/risk-of-herpes-zoster-shingles-in-patients-with-rheumatoid-arthritis-under-biologic-targeted-synthetic-and-conventional-synthetic-dmard-treatment-data-from-the-german-rabbit-register
#1
Imke Redeker, Katinka Albrecht, Joern Kekow, Gerd Rüdiger Burmester, Juergen Braun, Martin Schäfer, Angela Zink, Anja Strangfeld
OBJECTIVE: To compare event and incidence rates of herpes zoster (HZ), also known as shingles, in patients with rheumatoid arthritis under treatment with conventional synthetic (cs), targeted synthetic (ts) or biologic (b) disease-modifying antirheumatic drugs (DMARDs). METHODS: Patients were prospectively enrolled from 2007 until October 2020. Reported HZ events were assigned to ongoing treatments or those terminated within 1 month prior to the HZ event. Exposure-adjusted event rates (EAERs) of HZ were calculated per 1000 patient years (py) and adjusted HRs with 95% CIs computed...
July 28, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34285051/tgf%C3%AE-promotes-low-il10-producing-ilc2-with-profibrotic-ability-involved-in-skin-fibrosis-in-systemic-sclerosis
#2
Paôline Laurent, Benoit Allard, Pauline Manicki, Valérie Jolivel, Emeline Levionnois, Mohamed Jeljeli, Pauline Henrot, Julien Izotte, Damien Leleu, Alexis Groppi, Julien Seneschal, Joel Constans, Carlo Chizzolini, Christophe Richez, Pierre Duffau, Estibaliz Lazaro, Edouard Forcade, Thierry Schaeverbeke, Thomas Pradeu, Frédéric Batteux, Patrick Blanco, Cécile Contin-Bordes, Marie-Elise Truchetet
OBJECTIVE: Innate lymphoid cells-2 (ILC2) were shown to be involved in the development of lung or hepatic fibrosis. We sought to explore the functional and phenotypic heterogeneity of ILC2 in skin fibrosis within systemic sclerosis (SSc). METHODS: Blood samples and skin biopsies from healthy donor or patients with SSc were analysed by immunostaining techniques. The fibrotic role of sorted ILC2 was studied in vitro on dermal fibroblast and further explored by transcriptomic approach...
July 20, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34285050/immunotherapies-and-covid-19-mortality-a-multidisciplinary-open-data-analysis-based-on-fda-s-adverse-event-reporting-system
#3
Maximilian Pistor, Andreas G F Hoepner, Yanan Lin, Simon Jung, Claudio L Bassetti, Andrew Chan, Anke Salmen, Robert Hoepner
No abstract text is available yet for this article.
July 20, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34285049/determining-in-which-pre-arthritis-stage-hla-shared-epitope-alleles-and-smoking-exert-their-effect-on-the-development-of-rheumatoid-arthritis
#4
Fenne Wouters, Marc P Maurits, Laurette van Boheemen, Marloes Verstappen, Kulveer Mankia, Xanthe M E Matthijssen, Annemarie L Dorjée, Paul Emery, Rachel Knevel, Dirkjan van Schaardenburg, René E M Toes, Annette H M van der Helm-van Mil
OBJECTIVES: The human leukocyte antigen-shared epitope (HLA-SE) alleles and smoking are the most prominent genetic and environmental risk factors for rheumatoid arthritis (RA). However, at which pre-arthritis stage (asymptomatic/symptomatic) they exert their effect is unknown. We aimed to determine whether HLA-SE and smoking are involved in the onset of autoantibody positivity, symptoms (clinically suspect arthralgia (CSA)) and/or progression to clinical arthritis. METHODS: We performed meta-analyses on results from the literature on associations of HLA-SE and smoking with anti-citrullinated protein antibodies (ACPAs) in the asymptomatic population...
July 20, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34285048/sars-cov-2-vaccination-in-rituximab-treated-patients-b-cells-promote-humoral-immune-responses-in-the-presence-of-t-cell-mediated-immunity
#5
Daniel Mrak, Selma Tobudic, Maximilian Koblischke, Marianne Graninger, Helga Radner, Daniela Sieghart, Philipp Hofer, Thomas Perkmann, Helmuth Haslacher, Renate Thalhammer, Stefan Winkler, Stephan Blüml, Karin Stiasny, Judith H Aberle, Josef S Smolen, Leonhard X Heinz, Daniel Aletaha, Michael Bonelli
OBJECTIVES: Evidence suggests that B cell-depleting therapy with rituximab (RTX) affects humoral immune response after vaccination. It remains unclear whether RTX-treated patients can develop a humoral and T-cell-mediated immune response against SARS-CoV-2 after immunisation. METHODS: Patients under RTX treatment (n=74) were vaccinated twice with either mRNA-1273 or BNT162b2. Antibodies were quantified using the Elecsys Anti-SARS-CoV-2 S immunoassay against the receptor-binding domain (RBD) of the spike protein and neutralisation tests...
July 20, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34281904/treating-the-skin-with-biologics-in-patients-with-psoriasis-decreases-the-incidence-of-psoriatic-arthritis
#6
Maria Laura Acosta Felquer, Luciano LoGiudice, Maria Laura Galimberti, Javier Rosa, Luis Mazzuoccolo, Enrique R Soriano
OBJECTIVES: To compare the incidence of psoriatic arthritis (PsA) in patients with psoriasis (PsO) according to different treatments for their skin: topics/no treatment, conventional disease-modifying antirheumatic drugs (DMARDs) (cDMARDs) or biological DMARDs (bDMARDs). METHODS: Patients with PsO without PsA followed at a university hospital were included in this retrospective cohort study. Patients were classified according to their treatment in topics (topics, phototherapy or no treatment), cDMARDs (methotrexate and cyclosporine) and bDMARDs (tumour necrosis factor inhibitors (TNFi), interleukin 17 inhibitors (IL-17i) and IL-12-23i ((interleukin (IL) 12/IL-23 inhibitor))) groups...
July 19, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34272253/correspondence-on-sars-cov-2-vaccination-in-rituximab-treated-patients-evidence-for-impaired-humoral-but-inducible-cellular-immune-response
#7
LETTER
Timm H Westhoff, Felix S Seibert, Moritz Anft, Arturo Blazquez-Navarro, Sarah Skrzypczyk, Adrian Doevelaar, Bodo Hölzer, Krystallenia Paniskaki, Sebastian Dolff, Benjamin Wilde, Oliver Witzke, Juergen Braun, Ulrik Stervbo, Nina Babel
No abstract text is available yet for this article.
July 16, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34272252/pause-in-immunosuppressive-treatment-results-in-improved-immune-response-to-sars-cov-2-vaccine-in-autoimmune-patient-a-case-report
#8
Basil Golding, Youri Lee, Hana Golding, Surender Khurana
No abstract text is available yet for this article.
July 16, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34272251/response-to-correspondence-on-sars-cov-2-vaccination-in-rituximab-treated-patients-evidence-for-impaired-humoral-but-inducible-cellular-immune-response-by-westhoff-et-al
#9
Michael Bonelli, Daniel Aletaha
No abstract text is available yet for this article.
July 16, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34230032/retraction-dominant-b-cell-receptor-clones-in-peripheral-blood-predict-onset-of-arthritis-in-individuals-at-risk-for-rheumatoid-arthritis
#10
(no author information available yet)
No abstract text is available yet for this article.
July 6, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34230031/molecular-basis-for-clinical-diversity-between-autoantibody-subsets-in-diffuse-cutaneous-systemic-sclerosis
#11
Kristina Elizabeth Neergaard Clark, Corrado Campochiaro, Eszter Csomor, Adam Taylor, Katherine Nevin, Nicholas Galwey, Mary A Morse, Jennifer Singh, Yee Voan Teo, Voon H Ong, Emma Derrett-Smith, Nicolas Wisniacki, Shaun M Flint, Christopher P Denton
OBJECTIVES: Clinical heterogeneity is a cardinal feature of systemic sclerosis (SSc). Hallmark SSc autoantibodies are central to diagnosis and associate with distinct patterns of skin-based and organ-based complications. Understanding molecular differences between patients will benefit clinical practice and research and give insight into pathogenesis of the disease. We aimed to improve understanding of the molecular differences between key diffuse cutaneous SSc subgroups as defined by their SSc-specific autoantibodies METHODS: We have used high-dimensional transcriptional and proteomic analysis of blood and the skin in a well-characterised cohort of SSc (n=52) and healthy controls (n=16) to understand the molecular basis of clinical diversity in SSc and explore differences between the hallmark antinuclear autoantibody (ANA) reactivities...
July 6, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34226191/correspondence-on-efficacy-of-a-tight-control-and-treat-to-target-strategy-in-axial-spondyloarthritis-results-of-the-open-label-pragmatic-cluster-randomised-ticospa-trial
#12
LETTER
Weijie Wang, Yung-Heng Lee, James Cheng Chung Wei
No abstract text is available yet for this article.
July 5, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34226190/correspondence-on-role-of-joint-damage-malalignment-and-inflammation-in-articular-tenderness-in-rheumatoid-arthritis-psoriatic-arthritis-and-osteoarthritis
#13
LETTER
Quirine A Dumoulin, Xanthe M E Matthijssen, Fenne Wouters, Doortje I Krijbolder, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
No abstract text is available yet for this article.
July 5, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34226189/b-cell-depletion-impairs-vaccination-induced-cd8-t-cell-responses-in-a-type-i-interferon-dependent-manner
#14
Theresa Graalmann, Katharina Borst, Himanshu Manchanda, Lea Vaas, Matthias Bruhn, Lukas Graalmann, Mario Koster, Murielle Verboom, Michael Hallensleben, Carlos Alberto Guzmán, Gerd Sutter, Reinhold E Schmidt, Torsten Witte, Ulrich Kalinke
OBJECTIVES: The monoclonal anti-CD20 antibody rituximab is frequently applied in the treatment of lymphoma as well as autoimmune diseases and confers efficient depletion of recirculating B cells. Correspondingly, B cell-depleted patients barely mount de novo antibody responses during infections or vaccinations. Therefore, efficient immune responses of B cell-depleted patients largely depend on protective T cell responses. METHODS: CD8+ T cell expansion was studied in rituximab-treated rheumatoid arthritis (RA) patients and B cell-deficient mice on vaccination/infection with different vaccines/pathogens...
July 5, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34226188/ex-vivo-mass-cytometry-analysis-reveals-a-profound-myeloid-proinflammatory-signature-in-psoriatic-arthritis-synovial-fluid
#15
Nicole Yager, Suzanne Cole, Alicia Lledo Lara, Ash Maroof, Frank Penkava, Julian C Knight, Paul Bowness, Hussein Al-Mossawi
OBJECTIVES: A number of immune populations have been implicated in psoriatic arthritis (PsA) pathogenesis. This study used mass cytometry (CyTOF) combined with transcriptomic analysis to generate a high-dimensional dataset of matched PsA synovial fluid (SF) and blood leucocytes, with the aim of identifying cytokine production ex vivo in unstimulated lymphoid and myeloid cells. METHODS: Fresh SF and paired blood were either fixed or incubated with protein transport inhibitors for 6 hours...
July 5, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34226187/14-3-3-epsilon-is-an-intracellular-component-of-tnfr2-receptor-complex-and-its-activation-protects-against-osteoarthritis
#16
Wenyu Fu, Aubryanna Hettinghouse, Yujianan Chen, Wenhuo Hu, Xiang Ding, Meng Chen, Yuanjing Ding, Jyoti Mundra, Wenhao Song, Ronghan Liu, Young-Su Yi, Mukundan Attur, Jonathan Samuels, Eric Strauss, Philipp Leucht, Ran Schwarzkopf, Chuan-Ju Liu
OBJECTIVES: Osteoarthritis (OA) is the most common joint disease; however, the indeterminate nature of mechanisms by which OA develops has restrained advancement of therapeutic targets. TNF signalling has been implicated in the pathogenesis of OA. TNFR1 primarily mediates inflammation, whereas emerging evidences demonstrate that TNFR2 plays an anti-inflammatory and protective role in several diseases and conditions. This study aims to decipher TNFR2 signalling in chondrocytes and OA. METHODS: Biochemical copurification and proteomics screen were performed to isolate the intracellular cofactors of TNFR2 complex...
July 5, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34226186/response-to-correspondence-on-role-of-joint-damage-malalignment-and-inflammation-in-articular-tenderness-in-rheumatoid-arthritis-psoriatic-arthritis-and-osteoarthritis-by-dumoulin-et-al
#17
Irina Gessl, Daniel Aletaha, Peter Mandl
No abstract text is available yet for this article.
July 5, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34226185/nothing-about-us-without-us-involving-patient-collaborators-for-machine-learning-applications-in-rheumatology
#18
EDITORIAL
Stephanie J W Shoop-Worrall, Katherine Cresswell, Imogen Bolger, Beth Dillon, Kimme L Hyrich, Nophar Geifman
Novel machine learning methods open the door to advances in rheumatology through application to complex, high-dimensional data, otherwise difficult to analyse. Results from such efforts could provide better classification of disease, decision support for therapy selection, and automated interpretation of clinical images. Nevertheless, such data-driven approaches could potentially model noise, or miss true clinical phenomena. One proposed solution to ensure clinically meaningful machine learning models is to involve primary stakeholders in their development and interpretation...
July 5, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34215648/role-of-ultrasound-for-assessment-of-psoriatic-arthritis-patients-with-fibromyalgia
#19
Ari Polachek, Victoria Furer, Mirna Zureik, Sharon Nevo, Liran Mendel, David Levartovsky, Jonathan Wollman, Valerie Aloush, Reut Tzemach, Ofir Elalouf, Marina Anouk, Mark Berman, Ilana Kaufman, Or Carmi, Yael Lahat, Tali Eviatar, Hagit Padova, Hagit Sarbagil-Maman, Sara Borok, Adi Broyde, Lihi Eder, Daphna Paran, Ori Elkayam
OBJECTIVE: To investigate whether ultrasonography (US), as an objective imaging modality, can optimise the evaluation of disease activity in psoriatic arthritis (PsA) patients with concomitant fibromyalgia syndrome (FMS). METHODS: The study population included 156 consecutive PsA patients who were recruited prospectively and fulfilled the ClASsification criteria for Psoriatic ARthritis criteria. The patients underwent complete clinical evaluation including assessment of fulfilment of the 2016 fibromyalgia classification criteria...
July 2, 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/34215647/response-to-correspondence-on-impact-of-covid-19-pandemic-on-patients-with-large-vessels-vasculitis-in-italy-a-monocentric-survey-by-montero-et-al
#20
Alessandro Tomelleri, Lorenzo Dagna, Corrado Campochiaro
No abstract text is available yet for this article.
July 2, 2021: Annals of the Rheumatic Diseases
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