Deepanksha Datta, B Selvakumar, Akhil Dhanesh Goel, Sanskriti Chhibber, Vaibhav Kumar Varshney, Rajesh Kumar
OBJECTIVES: This study aims to evaluate the utility of F-18 FDG PET/CT in the non-invasive diagnosis of autoimmune pancreatitis (AIP) and differentiating it from pancreatic cancer (CaP) based on the amount and pattern of FDG uptake, as well as involvement of extra-pancreatic sites. METHODS: A systematic search was conducted using PubMed, Scopus, Cochrane Library and Google Scholar. Only those studies that compared the findings of F-18 FDG PET/CT in terms of SUVmax, pattern of FDG uptake and presence of FDG-avid extra-pancreatic sites in both AIP and CaP were included...
May 15, 2024: Annals of Nuclear Medicine
Wing-Keen Yap, Ken-Hao Hsu, Ting-Hao Wang, Chia-Hsin Lin, Chung-Jan Kang, Shih-Ming Huang, Huan-Chun Lin, Tsung-Min Hung, Kai-Ping Chang, Tsung-You Tsai
OBJECTIVE: The lymph node to primary tumor standardized uptake value ratio (NTR) is an innovative parameter derived from positron emission tomography/computed tomography (PET/CT) scans that captures the intricate relationship between primary tumors and associated lymph nodes. This meta-analysis aimed to investigate the prognostic value of NTR in cancer patients. METHODS: A systematic search of PubMed, Cochrane, and Embase databases was conducted to identify studies investigating the association between NTR and survival outcomes in cancer patients...
May 9, 2024: Annals of Nuclear Medicine
Hanne-Rinck Jeltema, Bart R J van Dijken, Katalin Tamási, Gea Drost, Mart A A M Heesters, Anouk van der Hoorn, Andor W J M Glaudemans, J Marc C van Dijk
OBJECTIVE: 11 C-Methionine positron emission tomography (MET-PET) is used for stereotactic radiotherapy planning in meningioma patients. The role of MET-PET during subsequent follow-up (FU) is unclear. We analyzed the uptake of 11 C-Methionine before and after stereotactic radiotherapy (SRT) in patients with a complex meningioma and investigated if there was a difference between patients with progressive disease (PD) and stable disease (SD) during FU. METHODS: This retrospective study investigates 62 MET-PETs in 29 complex meningioma patients...
May 8, 2024: Annals of Nuclear Medicine
Yuki Tomonari, Yuya Onishi, Fumio Hashimoto, Kibo Ote, Takashi Okamoto, Hiroyuki Ohba
OBJECTIVE: In preclinical studies, high-throughput positron emission tomography (PET) imaging, known as simultaneous multiple animal scanning, can reduce the time spent on animal experiments, the cost of PET tracers, and the risk of synthesis of PET tracers. It is well known that the image quality acquired by high-throughput imaging depends on the PET system. Herein, we investigated the influence of large field of view (FOV) PET scanner on high-throughput imaging. METHODS: We investigated the influence of scanning four objects using a small animal PET scanner with a large FOV...
May 8, 2024: Annals of Nuclear Medicine
Kun-Han Lue, Yu-Hung Chen, Sung-Chao Chu, Chih-Bin Lin, Tso-Fu Wang, Shu-Hsin Liu
OBJECTIVE: To investigate the prognostic value of 18 F-FDG PET-based intensity, volumetric features, and deep learning (DL) across different generations of PET scanners in patients with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma receiving tyrosine kinase inhibitor (TKI) treatment. METHODS: We retrospectively analyzed the pre-treatment 18 F-FDG PET of 217 patients with advanced-stage lung adenocarcinoma and actionable EGFR mutations who received TKI as first-line treatment...
May 5, 2024: Annals of Nuclear Medicine
Hacı Arak, Umut Elboga, Yusuf Burak Cayirli, Aydın Aytekin
OBJECTIVE: This study aimed to compare 18 FDGPET/CT in patients who develop bone metastases due to various cancers and to investigate the prognostic significance of the 68 FAPI-PET/CT SUVmax value for survival. METHODS: Patients with bone metastases who underwent both 68  Ga-FAPI PET/CT and 18 FDGPET/CT within a 1 week period were included in this retrospective study. The effect of the SUVmax value of bone lesions on overall survival was analyzed...
April 30, 2024: Annals of Nuclear Medicine
Nobuki Kazuta, Shohei Tsuchihashi, Hiroyuki Watanabe, Masahiro Ono
OBJECTIVE: The marked success of prostate-specific membrane antigen (PSMA)-targeting radioligands with albumin binder (ALB) is attributed to the improvement of blood retention and tumor accumulation. [111 In]In-PNT-DA1, our PSMA-targeting radioligand with ALB, also achieved improved tumor accumulation due to its prolonged blood retention. Although the advantage of ALBs is related to their reversible binding to albumin, the relationship between albumin-binding and tumor accumulation of PSMA-targeting radioligands remains unclear because of the lack of information about radioligands with stronger albumin-binding than ALBs...
April 27, 2024: Annals of Nuclear Medicine
Sharjeel Usmani, Najeeb Ahmed, Gopinath Gnanasegaran, Fahad Marafi, Ahmed Bani-Mustafa, Tim Van den Wyngaert
OBJECTIVE: The study aims to assess regional and total bone metabolic activity in patients with chronic kidney disease using Na[18 F]F PET and correlation between semi-quantitative indices and blood parameters. METHODS: Seventy-two subjects (mean age 61.8 ± 13.8 years) were included. Of these 24/72 patients had end-stage renal disease (ESRD) (GFR < 15 mL/min/1.73 m2 ), 38/72 had chronic kidney disease (CKD) (GFR between 60 and 15 mL/min/1...
April 27, 2024: Annals of Nuclear Medicine
Naoto Wakabayashi, Shiro Watanabe, Takashige Abe, Junki Takenaka, Kenji Hirata, Rina Kimura, Keita Sakamoto, Nobuo Shinohara, Kohsuke Kudo
OBJECTIVE: To investigate the incidence of adverse events (AEs) following single and multiple administrations of I-131 metaiodobenzylguanidine (MIBG) therapy for inoperable pheochromocytomas and paragangliomas (PPGLs). METHODS: A single-center retrospective study was conducted on patients with inoperable PPGLs who underwent I-131 MIBG therapy between January 2000 and December 2020. A total of 28 patients with available electronic medical records were included. The treatment consisted of a single intravenous administration of 150 mCi (5...
April 24, 2024: Annals of Nuclear Medicine
Hsi-Huei Lu, Nan-Tsing Chiu, Mu-Hung Tsai
OBJECTIVE: Radium-223 (Ra-223) is an important treatment modality for bone-dominant metastatic castration-resistant prostate cancer (mCRPC). However, there is currently a lack of effective markers to monitor treatment response during treatment. We aim to investigate the response in prostate-specific antigen doubling time (PSADT) as a potential marker for assessing Ra-223 treatment in mCRPC patients. METHODS: We retrospectively collected data from mCRPC patients who underwent radium treatment at our institution between August 2020 and June 2023...
April 22, 2024: Annals of Nuclear Medicine
Nazim Coskun, Mehmet Oguz Kartal, Aysenur Sinem Kartal, Velihan Cayhan, Mustafa Ozdemir, Murat Canyigit, Elif Ozdemir
INTRODUCTION: Voxel-based dosimetry offers improved outcomes in the treatment of hepatocellular carcinoma (HCC) with transarterial radioembolization (TARE) using glass microspheres. However, the adaptation of voxel-based dosimetry to resin-based microspheres has been poorly studied, and the prognostic relevance of heterogeneous dose distribution remains unclear. This study aims to explore the use of dose-volume histograms for resin microspheres and to determine thresholds for objective metabolic response in HCC patients treated with resin-based TARE...
April 22, 2024: Annals of Nuclear Medicine
Xia Zheng, Chunxia Li, Jing Ai, Guili Dong, Man Long, Mingyi Li, Shilin Qiu, Yanni Huang, Guangjun Yang, Tao Zhang, Zhenhui Li
OBJECTIVE: To investigate the survival benefit of preoperative bone scan in asymptomatic patients with early-stage non-small cell lung cancer (NSCLC). METHODS: This retrospective study included patients with radical resection for stage T1N0M0 NSCLC between March 2013 and December 2018. During postoperative follow-up, we monitored patient survival and the development of bone metastasis. We compared overall survival, bone metastasis-free survival, and recurrence-free survival in patients with or without preoperative bone scan...
April 11, 2024: Annals of Nuclear Medicine
Changhwan Sung, Jungsu S Oh, Byung Soo Park, Su Ssan Kim, Si Yeol Song, Jong Jin Lee
OBJECTIVE: We developed a deep learning model for distinguishing radiation therapy (RT)-related changes and tumour recurrence in patients with lung cancer who underwent RT, and evaluated its performance. METHODS: We retrospectively recruited 308 patients with lung cancer with RT-related changes observed on 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (18 F-FDG PET/CT) performed after RT. Patients were labelled as positive or negative for tumour recurrence through histologic diagnosis or clinical follow-up after 18 F-FDG PET/CT...
April 8, 2024: Annals of Nuclear Medicine
Seyyed Ali Hosseini, Isaac Shiri, Pardis Ghaffarian, Ghasem Hajianfar, Atlas Haddadi Avval, Milad Seyfi, Stijn Servaes, Pedro Rosa-Neto, Habib Zaidi, Mohammad Reza Ay
PURPOSE: This study aimed to examine the robustness of positron emission tomography (PET) radiomic features extracted via different segmentation methods before and after ComBat harmonization in patients with non-small cell lung cancer (NSCLC). METHODS: We included 120 patients (positive recurrence = 46 and negative recurrence = 74) referred for PET scanning as a routine part of their care. All patients had a biopsy-proven NSCLC. Nine segmentation methods were applied to each image, including manual delineation, K-means (KM), watershed, fuzzy-C-mean, region-growing, local active contour (LAC), and iterative thresholding (IT) with 40, 45, and 50% thresholds...
April 4, 2024: Annals of Nuclear Medicine
Hongyan Yin, Guobing Liu, Wujian Mao, Jing Lv, Haojun Yu, Dengfeng Cheng, Liang Cai, Hongcheng Shi
OBJECTIVES: There has been developed a clinical dynamic total-body 68 Ga-DOTATATE PET/CT imaging protocol that allows quantitative imaging of net influx rate (Ki ). Using qualitative and quantitative analyses of clinical studies, this retrospective study aims to assess whether parametric Ki images improve lesion detectability. METHODS: Using a 194-cm axial field-of-view PET/CT scanner, 52 patients with neuroendocrine tumors underwent a 60-min dynamic total-body 68 Ga-DOTATATE scan...
April 4, 2024: Annals of Nuclear Medicine
Keiko Takahashi, Osamu Manabe, Kazuya Shizukuishi, Hirohumi Shibata, Hiroki Kawakami, Akira Otsuka, Noriko Oyama-Manabe
PURPOSE: This study aimed to investigate the frequency of COVID-19 vaccine-induced reactive change and potential factors including blood type correlated with increased FDG uptake on positron emission tomography (PET)/computed tomography (CT). MATERIALS AND METHODS: We evaluated 284 patients who underwent PET/CT between June and September 2021 and had a known history of COVID-19 vaccination. Information on the injection site, vaccine type, and adverse reactions was obtained...
April 2, 2024: Annals of Nuclear Medicine
Tadashi Watabe, Masao Namba, Sachiko Yanagida, Yoshihide Nakamura, Takahiro Yamada, Saori Tatsuno, Aritoshi Ri, Shuhei Yoshida, Kumiko Uyama, Seigo Kinuya, Noriyuki Tomiyama, Makoto Hosono
Recently, an astatine-labeled prostate-specific membrane antigen (PSMA) ligand ([211 At]PSMA-5) has been developed for the targeted alpha therapy of patients with prostate cancer. This manual delineates its physicochemical characteristics to assist healthcare professionals in understanding the α-ray-emitting drug of [211 At]PSMA-5 when administered to patients. The safety considerations regarding the handling and use of this drug in clinical trials are outlined, based on the proper usage manual of previous studies...
March 28, 2024: Annals of Nuclear Medicine
Kentaro Tamura, Ryuichi Nishii, Kotaro Tani, Hiroki Hashimoto, Kazunori Kawamura, Ming-Rong Zhang, Takamasa Maeda, Kana Yamazaki, Tatsuya Higashi, Masahiro Jinzaki
PURPOSE: N-benzyl-N-methyl-2-[7, 8-dihydro-7-(2-[18 F] fluoroethyl) -8-oxo-2-phenyl-9H-purin-9-yl] acetamide ([18 F] FEDAC) is a novel positron emission tomography (PET) tracer that targets the translocator protein (TSPO; 18 kDa) in the mitochondrial outer membrane, which is known to be upregulated in various diseases such as malignant tumors, neurodegenerative diseases, and neuroinflammation. This study presents the first attempt to use [18 F]FEDAC PET/CT and evaluate its biodistribution as well as the systemic radiation exposure to the radiotracer in humans...
April 2024: Annals of Nuclear Medicine
Siamak Derakhshan, Bayazid Ghaderi, Daem Roshani
OBJECTIVES: Early diagnosis of chemotherapy-induced cardiotoxicity plays an important role in preventing heart failure. The main aim of our study was to assess left ventricular (LV) dyssynchrony measured by phase analysis of gated single-photon emission computed tomography (SPECT) as an early sign of cardiotoxicity after breast cancer chemotherapy. METHODS: This cross-sectional study was conducted on patients with stage ≤ 3 breast cancer and no history of cardiovascular disease or diabetes...
April 2024: Annals of Nuclear Medicine
Luqiang Jin, Linghe Zhang, Liping Fu, Fahuan Song, Aiping Cheng
PURPOSE: This study aimed to use an 18 F-FDG PET/CT multiparametric quantitative analysis to determine the efficacy of neoadjuvant chemotherapy in patients with locally progressive gastric cancer. MATERIALS AND METHODS: We conducted a retrospective analysis of 34 patients with pathologically identified gastric cancer who received neoadjuvant chemotherapy and surgery. Chemotherapy regimens were followed and 18 F-FDG PET/CT was conducted. We ascertained multiparamaters of the target lesions pre- and post-treatment and determined the ideal cutoff values for the percentage change in biomarkers...
March 27, 2024: Annals of Nuclear Medicine
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.