Dae Hyun Kim, Su Been Lee, Chan Mi Park, Raisa Levin, Eran Metzger, Brian T Bateman, E Wesley Ely, Pratik P Pandharipande, Margaret A Pisani, Richard N Jones, Edward R Marcantonio, Sharon K Inouye
BACKGROUND: Antipsychotics are commonly used to manage postoperative delirium. Recent studies reported that haloperidol use has declined, and atypical antipsychotic use has increased over time. OBJECTIVE: To compare the risk for in-hospital adverse events associated with oral haloperidol, olanzapine, quetiapine, and risperidone in older patients after major surgery. DESIGN: Retrospective cohort study. SETTING: U.S. hospitals in the Premier Healthcare Database...
September 5, 2023: Annals of Internal Medicine