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Alfonso Iorio, Jeffrey S Stonebraker, Hervé Chambost, Michael Makris, Donna Coffin, Christine Herr, Federico Germini
Background: The large observed variability in hemophilia prevalence prevents robust estimation of burden of disease. Objective: To estimate the prevalence and prevalence at birth of hemophilia and the associated life expectancy disadvantage. Design: Random-effects meta-analysis of registry data. Setting: Australia, Canada, France, Italy, New Zealand, and the United Kingdom. Participants: Male patients with hemophilia A or B...
September 10, 2019: Annals of Internal Medicine
#2
JoAnn E Manson, Aaron K Aragaki, Shari S Bassuk, Rowan T Chlebowski, Garnet L Anderson, Jacques E Rossouw, Barbara V Howard, Cynthia A Thomson, Marcia L Stefanick, Andrew M Kaunitz, Carolyn J Crandall, Charles B Eaton, Victor W Henderson, Simin Liu, Juhua Luo, Thomas Rohan, Aladdin H Shadyab, Gretchen Wells, Jean Wactawski-Wende, Ross L Prentice
Background: Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown. Objective: To examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age groups. Design: Subgroup analyses of the randomized Women's Health Initiative Estrogen-Alone Trial. (ClinicalTrials.gov: NCT00000611). Setting: 40 U.S. clinical centers...
September 10, 2019: Annals of Internal Medicine
#3
David J Whellan
No abstract text is available yet for this article.
September 10, 2019: Annals of Internal Medicine
#4
(no author information available yet)
No abstract text is available yet for this article.
September 10, 2019: Annals of Internal Medicine
#5
J Michael Soucie
No abstract text is available yet for this article.
September 10, 2019: Annals of Internal Medicine
#6
Maria Polyakova, Lynn M Hua
Background: Recent studies have reported that low-income adults living in more affluent areas of the United States have longer life expectancies. Less is known about the relationship between the affluence of a geographic area and morbidity of the low-income population. Objective: To evaluate the association between the prevalence of chronic conditions among low-income, older adults and the economic affluence of a local area. Design: Cross-sectional association study...
September 10, 2019: Annals of Internal Medicine
#7
Vinayak Shenoy, Matthew Ballenberger, Adam Prince, Stephen Maslak
No abstract text is available yet for this article.
September 10, 2019: Annals of Internal Medicine
#8
Denelle Mohammed
No abstract text is available yet for this article.
September 10, 2019: Annals of Internal Medicine
#9
Giovanni Peretto, Chiara Di Resta, Jacopo Perversi, Cinzia Forleo, Lorenzo Maggi, Luisa Politano, Andrea Barison, Stefano C Previtali, Nicola Carboni, Francesca Brun, Elena Pegoraro, Adele D'Amico, Carmelo Rodolico, Francesca Magri, Rosa C Manzi, Alberto Palladino, Franco Isola, Lorenzo Gigli, Tiziana E Mongini, Claudio Semplicini, Chiara Calore, Giulia Ricci, Giacomo P Comi, Lucia Ruggiero, Enrico Bertini, Paolo Bonomo, Gerardo Nigro, Nicoletta Resta, Michele Emdin, Stefano Favale, Gabriele Siciliano, Lucio Santoro, Gianfranco Sinagra, Giuseppe Limongelli, Alessandro Ambrosi, Maurizio Ferrari, Pier G Golzio, Paolo Della Bella, Sara Benedetti, Simone Sala
Background: Mutations in the LMNA (lamin A/C) gene have been associated with neuromuscular and cardiac manifestations, but the clinical implications of these signs are not well understood. Objective: To learn more about the natural history of LMNA-related disease. Design: Observational study. Setting: 13 clinical centers in Italy from 2000 through 2018. Patients: 164 carriers of an LMNA mutation...
September 3, 2019: Annals of Internal Medicine
#10
Roozbeh Nikooie, Karin J Neufeld, Esther S Oh, Lisa M Wilson, Allen Zhang, Karen A Robinson, Dale M Needham
Background: Delirium is common in hospitalized patients and is associated with worse outcomes. Antipsychotics are commonly used; however, the associated benefits and harms are unclear. Purpose: To conduct a systematic review evaluating the benefits and harms of antipsychotics to treat delirium in adults. Data Sources: PubMed, Embase, CENTRAL, CINAHL, and PsycINFO from inception to July 2019 without language restrictions. Study Selection: Randomized controlled trials (RCTs) of antipsychotic versus placebo or another antipsychotic, and prospective observational studies reporting harms...
September 3, 2019: Annals of Internal Medicine
#11
Stephanie Wright, Ian Mudway
No abstract text is available yet for this article.
September 3, 2019: Annals of Internal Medicine
#12
Edward R Marcantonio
No abstract text is available yet for this article.
September 3, 2019: Annals of Internal Medicine
#13
Rhys Harrison, Vicki Warburton, Andrew Lux, Denize Atan
No abstract text is available yet for this article.
September 3, 2019: Annals of Internal Medicine
#14
Esther S Oh, Dale M Needham, Roozbeh Nikooie, Lisa M Wilson, Allen Zhang, Karen A Robinson, Karin J Neufeld
Background: Delirium is an acute disorder marked by impairments in attention and cognition, caused by an underlying medical problem. Antipsychotics are used to prevent delirium, but their benefits and harms are unclear. Purpose: To conduct a systematic review evaluating the benefits and harms of antipsychotics for prevention of delirium in adults. Data Sources: PubMed, Embase, CENTRAL, CINAHL, and PsycINFO from inception through July 2019, without restrictions based on study setting, language of publication, or length of follow-up...
September 3, 2019: Annals of Internal Medicine
#15
Philipp Schwabl, Sebastian Köppel, Philipp Königshofer, Theresa Bucsics, Michael Trauner, Thomas Reiberger, Bettina Liebmann
Background: Microplastics are ubiquitous in natural environments. Ingestion of microplastics has been described in marine organisms, whereby particles may enter the food chain. Objective: To examine human feces for the presence of microplastics to determine whether humans involuntarily ingest them. Design: Prospective case series in which participants completed a food diary and sampled stool according to step-by-step instructions. Setting: Europe and Asia...
September 3, 2019: Annals of Internal Medicine
#16
Arkady Rasin, Jason M Devgun, Daniel G Nosal, Timothy J Meehan, Richard B van Breemen, Trevonne M Thompson
No abstract text is available yet for this article.
August 27, 2019: Annals of Internal Medicine
#17
Eric D Caine
No abstract text is available yet for this article.
August 27, 2019: Annals of Internal Medicine
#18
Michael Hogan
No abstract text is available yet for this article.
August 27, 2019: Annals of Internal Medicine
#19
Roger Chou, Jane Ballantyne, Anna Lembke
No abstract text is available yet for this article.
August 27, 2019: Annals of Internal Medicine
#20
Kristen E D'Anci, Stacey Uhl, Gina Giradi, Constance Martin
Background: Suicide is a growing public health problem, with the national rate in the United States increasing by 30% from 2000 to 2016. Purpose: To assess the benefits and harms of nonpharmacologic and pharmacologic interventions to prevent suicide and reduce suicide behaviors in at-risk adults. Data Sources: MEDLINE, EMBASE, PsycINFO, and other databases from November 2011 through May 2018. Study Selection: Systematic reviews (SRs) and randomized controlled trials (RCTs) that assessed nonpharmacologic or pharmacologic therapies for adults at risk for suicide...
August 27, 2019: Annals of Internal Medicine
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