journal
https://read.qxmd.com/read/38517762/metformin-use-in-type-2-diabetics-and-delirium-after-noncardiac-surgery-a-retrospective-cohort-analysis
#21
JOURNAL ARTICLE
Stephania Paredes, Ayoub Harb, Julian Rössler, Maede Zookaei Nikoo, Kurt Ruetzler, Alparslan Turan, Xuan Pu, Daniel I Sessler
INTRODUCTION: The cause of postoperative delirium is unknown, but it is thought to result at least in part from inflammation. Metformin, besides its hypoglycemic properties, demonstrates anti-inflammatory effects systemically and in the brain. We tested the primary hypothesis that chronic metformin use in adults with type 2 diabetes is associated with less delirium during the first 5 days after major noncardiac surgery. Secondary outcomes were a composite of serious complications (myocardial infarction, cardiac arrest, stage 2-3 acute kidney injury [AKI], and mortality) and time to discharge alive...
March 22, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38517760/society-for-ambulatory-anesthesia-updated-consensus-statement-on-perioperative-blood-glucose-management-in-adult-patients-with-diabetes-mellitus-undergoing-ambulatory-surgery
#22
JOURNAL ARTICLE
Niraja Rajan, Elizabeth W Duggan, Basem B Abdelmalak, Steven Butz, Leopoldo V Rodriguez, Mary Ann Vann, Girish P Joshi
WHAT OTHER GUIDELINES ARE AVAILABLE ON THIS TOPIC: Since the publication of the SAMBA Consensus Statement for perioperative blood glucose management in the ambulatory setting in 2010, several recent guidelines have been issued by the American Diabetes Association (ADA), the American Association of Clinical Endocrinologists (AACE), the Endocrine Society, the Centre for Perioperative Care (CPOC), and the Association of Anaesthetists of Great Britain and Ireland (AAGBI) on DM care in hospitalized patients; however, none are specific to ambulatory surgery...
March 22, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507557/evaluation-of-thrombin-and-plasmin-generation-velocity-ratios-during-progressive-plasma-dilution
#23
JOURNAL ARTICLE
Rui Terada, Yuko Mishima, BreAnna Le, Amir L Butt, Jerrold H Levy, Kenichi A Tanaka
No abstract text is available yet for this article.
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507554/involvement-of-spinal-neuroplastin-65-in-neuropathic-pain-by-gabaa-receptor-%C3%AE-2-subunit-regulation
#24
JOURNAL ARTICLE
Li Xu, Yu Wang, Yang Jiao, Yulin Huang, Rui Xu, Xiaoping Gu, Wei Zhang, Zhengliang Ma
BACKGROUND: Neuropathic pain (NP) is a highly challenging condition with complex pathological mechanisms, and the spinal gamma aminobutyric acid A receptor receptor plays a crucial role in its progression. Recent studies have revealed a potential interaction between neuroplastin 65 (NP65) and gamma aminobutyric acid A receptor α2 subunit (GABAAR-α2) on the cell surface. We hypothesize that NP65 is involved in the pathogenesis of NP by regulating the level of GABAAR-α2...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507523/anesthetic-sevoflurane-induces-enlargement-of-dendritic-spine-heads-in-mouse-neurons-via-tau-dependent-mechanisms
#25
JOURNAL ARTICLE
Jia Yan, Hoai Ton, Jing Yan, Yuanlin Dong, Zhongcong Xie, Hong Jiang
BACKGROUND: Sevoflurane induces neuronal dysfunction and cognitive impairment. However, the underlying mechanism remains largely to be determined. Tau, cyclophilin D, and dendritic spine contribute to cognitive function. But whether changes in dendritic spines are involved in the effects of sevoflurane and the potential association with tau and cyclophilin D is not clear. METHODS: We harvested hippocampal neurons from wild-type mice, tau knockout mice, and cyclophilin D knockout mice...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507520/james-watt-of-steam-engine-fame-offered-inhaled-carbon-monoxide-for-putative-therapeutic-action
#26
JOURNAL ARTICLE
Olivia W Xu, Jingping Wang, Theodore A Alston
James Watt (1736-1819) is remembered as a steam engine innovator and industrial magnate. A polymath, he was also a hands-on contributor to the Medical Pneumatic Institution of Thomas Beddoes. Watt recruited Humphry Davy, who there discovered analgesic action of inhaled nitrous oxide in 1799. Watt also built pneumatic equipment, and he introduced a gas mixture, dubbed hydro-carbonate, as a medical tonic. The bioactive component was carbon monoxide, a readily-lethal inhibitor of the transport and utilization of respiratory oxygen...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507503/abstracts-of-international-research-society-society-of-critical-care-anesthesiologists-2023-annual-meetings-erratum
#27
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507476/brain-hazardous-medications-and-potential-subadequate-antidepressant-dosing-in-older-surgical-patients-receiving-home-antidepressants-an-observational-study-of-a-large-us-health-system
#28
JOURNAL ARTICLE
Bethany R Tellor Pennington, Katherine J Holzer, Bradley A Fritz, Simon Haroutounian, Kevin Y Xu, Amanda Tedder, Alex Kronzer, Michael S Avidan, Eric J Lenze
BACKGROUND: Older surgical patients with depression often experience poor postoperative outcomes. Poor outcomes may stem from brain-hazardous medications and subadequate antidepressant dosing. METHODS: This was a retrospective, observational cohort study covering the period between January 1, 2021 and December 31, 2021. Patients ≥60 years of age who underwent inpatient surgery and had an overnight stay at an integrated academic health care system comprising 14 hospitals were eligible...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38493440/persistent-opioid-use-after-hospital-admission-from-surgery-in-new-zealand-a-population-based-study
#29
JOURNAL ARTICLE
Jiayi Gong, Peter Jones, Chris Frampton, Kebede Beyene, Amy Hai Yan Chan
BACKGROUND: Persistent opioid use (POU) is common after surgery and is associated with an increased risk of mortality and morbidity. There have been no population-based studies exploring POU in opioid-naïve surgical patients in New Zealand (NZ). This study aimed to determine the incidence and risk factors for POU in opioid-naïve patients undergoing surgery in all NZ hospitals. METHOD: We included all opioid-naïve patients who underwent surgery without a concomitant trauma diagnosis and received opioids after discharge from any NZ hospital between January 2007 and December 2019...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38478876/smallest-clinically-meaningful-improvement-in-amputation-related-pain-and-brief-pain-inventory-scores-as-defined-by-patient-reports-of-global-improvement-after-cryoneurolysis-a-retrospective-analysis-of-a-randomized-controlled-clinical-trial
#30
JOURNAL ARTICLE
Brian M Ilfeld, Cameron R Smith, Alparslan Turan, Edward R Mariano, Matthew E Miller, Rick L Fisher, Andrea M Trescot, Steven P Cohen, James C Eisenach, Daniel I Sessler, J David Prologo, Edward J Mascha, Liu Liu, Rodney A Gabriel
BACKGROUND: The smallest meaningful improvement in pain scores (minimal clinically important difference [MCID]) after an analgesic intervention is essential information when both interpreting published data and designing a clinical trial. However, limited information is available for patients with chronic pain conditions, and what is published is derived from studies involving pharmacologic and psychological interventions. We here calculate these values based on data collected from 144 participants of a previously published multicenter clinical trial investigating the effects of a single treatment with percutaneous cryoneurolysis...
March 14, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38470844/jury-duty-i-saw-the-origin-and-the-aftermath
#31
JOURNAL ARTICLE
Joanna M Schindler
No abstract text is available yet for this article.
March 12, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38470828/the-global-anesthesia-workforce-survey-updates-and-trends-in-the-anesthesia-workforce
#32
JOURNAL ARTICLE
Tyler J Law, Michael S Lipnick, Wayne Morriss, Adrian W Gelb, Jannicke Mellin-Olsen, Daniela Filipescu, Jackie Rowles, Pascal Rod, Fauzia Khan, Patrica Yazbeck, Eugene Zoumenou, Pedro Ibarra, Kumudini Ranatunga, Fred Bulamba
BACKGROUND: There is a large global deficit of anesthesia providers. In 2016, the World Federation of Societies of Anaesthesiologists (WFSA) conducted a survey to count the number of anesthesia providers worldwide. Much work has taken place since then to strengthen the anesthesia health workforce. This study updates the global count of anesthesia providers. METHODS: Between 2021 and 2023, an electronic survey was sent to national professional societies of physician anesthesia providers (PAPs), nurse anesthetists, and other nonphysician anesthesia providers (NPAPs)...
March 12, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38470823/clavipectoral-fascia-and-clavipectoral-fascia-plane-block-to-be-or-not-to-be
#33
JOURNAL ARTICLE
Cristina Heredia-Carqués, Hipólito Labandeyra, Marta Castellanos, Luis F Váldes-Vilches, Xavier Tomás, Xavier Sala-Blanch
No abstract text is available yet for this article.
March 12, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38470822/three-messages-to-enhance-human-connection-with-our-patients
#34
JOURNAL ARTICLE
Carolina S Romero, Ursula Speck, Nicole Stern, Markus M Luedi
No abstract text is available yet for this article.
March 12, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38470821/silent-night-a-story-of-surgery-on-christmas-eve
#35
JOURNAL ARTICLE
Antonio Yaghy
No abstract text is available yet for this article.
March 12, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38451869/not-even-a-whisper-on-losing-one-s-voice
#36
JOURNAL ARTICLE
Alan M Smeltz
No abstract text is available yet for this article.
March 7, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38451862/it-is-time-to-prioritize-treatment-burden-if-we-want-to-deliver-truly-patient-centered-perioperative-care
#37
JOURNAL ARTICLE
Wan Chin Lim, Jugdeep K Dhesi
No abstract text is available yet for this article.
March 7, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38446709/lack-of-validity-of-absolute-percentage-errors-in-estimated-operating-room-case-durations-as-a-measure-of-operating-room-performance-a-focused-narrative-review
#38
JOURNAL ARTICLE
Franklin Dexter, Richard H Epstein
Commonly reported end points for operating room (OR) and surgical scheduling performance are the percentages of estimated OR times whose absolute values differ from the actual OR times by ≥15%, or by various intervals from ≥5 to ≥60 minutes. We show that these metrics are invalid assessments of OR performance. Specifically, from 19 relevant articles, multiple OR management decisions that would increase OR efficiency or productivity would also increase the absolute percentage error of the estimated case durations...
March 6, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38446706/enhancing-outcomes-in-clinical-practice-lessons-learned-in-the-quality-improvement-trenches
#39
JOURNAL ARTICLE
Elizabeth E Hansen, Jennifer L Chiem, Daniel K Low, Sally E Rampersad, Lynn D Martin
No abstract text is available yet for this article.
March 6, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38446705/association-of-intravenous-neostigmine-and-anticholinergics-or-sugammadex-with-postoperative-delirium-a-retrospective-cohort-study
#40
JOURNAL ARTICLE
Julian Rössler, Emily Abramczyk, Stephania Paredes, Nikola Anusic, Xuan Pu, Kamal Maheshwari, Alparslan Turan, Kurt Ruetzler
BACKGROUND: Administration of cholinesterase inhibitors in combination with anticholinergic drugs for reversal of neuromuscular blocks may precipitate delirium through impairment of central cholinergic transmission, which could be avoided by using sugammadex. Therefore, we tested the primary hypothesis that postoperative delirium is less common when neuromuscular block is reversed with sugammadex than with neostigmine combined with glycopyrrolate or atropine. METHODS: We conducted a single-center retrospective cohort study, analyzing all adult patients having general anesthesia for noncardiac surgery who received neostigmine or sugammadex from January 2016 to March 2022...
March 6, 2024: Anesthesia and Analgesia
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