journal
https://read.qxmd.com/read/38630032/physick-to-physiology-tales-from-an-oxford-life-in-medicine
#1
JOURNAL ARTICLE
Alistair G McKenzie
No abstract text is available yet for this article.
April 11, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38578871/cardiovascular-kidney-metabolic-syndrome-association-with-adverse-events-after-major-noncardiac-surgery
#2
JOURNAL ARTICLE
Sebastian Roth, René M'Pembele, Purificación Matute, Katarzyna Kotfis, Jan Larmann, Giovanna Lurati Buse
BACKGROUND: The American Heart Association (AHA) recently defined the cardiovascular-kidney-metabolic syndrome (CKM) as a new entity to address the complex interactions between heart, kidneys, and metabolism. The aim of this study was to assess the outcome impact of CKM syndrome in patients undergoing noncardiac surgery. METHODS: This is a secondary analysis of a prospective international cohort study including patients aged ≥45 years with increased cardiovascular risk undergoing noncardiac surgery...
April 5, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38578868/opioid-sparing-anesthesia-versus-opioid-free-anesthesia-for-the-prevention-of-postoperative-nausea-and-vomiting-after-laparoscopic-bariatric-surgery-a-systematic-review-and-network-meta-analysis
#3
JOURNAL ARTICLE
Yichan Ao, Jingyue Ma, Xiaozhuo Zheng, Jie Zeng, Ke Wei
BACKGROUND: Patients who undergo laparoscopic bariatric surgery (LBS) are susceptible to postoperative nausea and vomiting (PONV). Opioid-free anesthesia (OFA) or opioid-sparing anesthesia (OSA) protocols have been proposed as solutions; however, differences between the 2 alternative opioid protocols for anesthesia maintenance in obese patients remain uncertain. A network meta-analysis was conducted to compare the impacts of OFA and OSA on PONV. METHODS: Systematic searches were conducted using Embase, PubMed, MEDLINE, and Cochrane Library databases to identify randomized controlled trials (RCTs) comparing OFA and OSA strategies...
April 5, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38578867/balanced-crystalloids-versus-normal-saline-in-kidney-transplant-patients-an-updated-systematic-review-meta-analysis-and-trial-sequential-analysis
#4
JOURNAL ARTICLE
Lucas Carvalho Pereira, Igor Carvalho Pereira, Thamiris Dias Delfino Cabral, Patricia Viana, Arthur Mendonça Ribeiro, Sara Amaral
BACKGROUND: The use of balanced crystalloids over normal saline for perioperative fluid management during kidney transplantation and its benefits on acid-base and electrolyte balance along with its influence on postoperative clinical outcomes remains a topic of controversy. Therefore, we conducted this review to assess the impact of balanced solutions compared to normal saline on outcomes for kidney transplant patients. METHODS: We searched MEDLINE, EMBASE, and Cochrane databases for randomized controlled trials (RCTs) comparing balanced lower-chloride solutions to normal saline in renal transplant patients...
April 5, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38557728/the-future-of-artificial-intelligence-using-images-and-clinical-assessment-for-difficult-airway-management
#5
JOURNAL ARTICLE
Silvia De Rosa, Elena Bignami, Valentina Bellini, Denise Battaglini
Artificial intelligence (AI) algorithms, particularly deep learning, are automatic and sophisticated methods that recognize complex patterns in imaging data providing high qualitative assessments. Several machine-learning and deep-learning models using imaging techniques have been recently developed and validated to predict difficult airways. Despite advances in AI modeling. In this review article, we describe the advantages of using AI models. We explore how these methods could impact clinical practice. Finally, we discuss predictive modeling for difficult laryngoscopy using machine-learning and the future approach with intelligent intubation devices...
April 1, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38536739/a-scoping-review-of-the-mechanisms-underlying-developmental-anesthetic-neurotoxicity
#6
JOURNAL ARTICLE
Matthew Thomas Borzage, Bradley S Peterson
Although anesthesia makes painful or uncomfortable diagnostic and interventional health care procedures tolerable, it may also disrupt key cellular processes in neurons and glia, harm the developing brain, and thereby impair cognition and behavior in children. Many years of studies using in vitro, animal behavioral, retrospective database studies in humans, and several prospective clinical trials in humans have been invaluable in discerning the potential toxicity of anesthetics. The objective of this scoping review was to synthetize the evidence from preclinical studies for various mechanisms of toxicity across diverse experimental designs and relate their findings to those of recent clinical trials in real-world settings...
March 27, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38530909/greater-than-sevenfold-return-on-investment-for-a-comprehensive-patient-blood-management-program-with-equivalent-or-improved-outcomes
#7
JOURNAL ARTICLE
Steven M Frank, Nadia B Hensley, Ananda J Thomas, Clarita G Dawson, Linda M S Resar, John A Ulatowski, Elizabeth P Crowe
No abstract text is available yet for this article.
March 25, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38530905/a-question-of-timing-when-death-is-not-defeat
#8
JOURNAL ARTICLE
Douglas Preston Grove
No abstract text is available yet for this article.
March 25, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38517763/care-of-the-pediatric-patient-for-ambulatory-tonsillectomy-with-or-without-adenoidectomy-the-society-for-ambulatory-anesthesia-position-statement
#9
JOURNAL ARTICLE
Marjorie P Brennan, Audra M Webber, Chhaya V Patel, Wanda A Chin, Steven F Butz, Niraja Rajan
The landscape of ambulatory surgery is changing, and tonsillectomy with or without adenoidectomy is one of the most common pediatric surgical procedures performed nationally. The number of children undergoing tonsillectomy on an ambulatory basis continues to increase. The 2 most common indications for tonsillectomy are recurrent throat infections and obstructive sleep-disordered breathing. The most frequent early complications after tonsillectomy are hemorrhage and ventilatory compromise. In areas lacking a dedicated children's hospital, these cases are managed by a nonpediatric specialized anesthesiologist and general otolaryngology surgeon...
March 22, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38517762/metformin-use-in-type-2-diabetics-and-delirium-after-noncardiac-surgery-a-retrospective-cohort-analysis
#10
JOURNAL ARTICLE
Stephania Paredes, Ayoub Harb, Julian Rössler, Maede Zookaei Nikoo, Kurt Ruetzler, Alparslan Turan, Xuan Pu, Daniel I Sessler
INTRODUCTION: The cause of postoperative delirium is unknown, but it is thought to result at least in part from inflammation. Metformin, besides its hypoglycemic properties, demonstrates anti-inflammatory effects systemically and in the brain. We tested the primary hypothesis that chronic metformin use in adults with type 2 diabetes is associated with less delirium during the first 5 days after major noncardiac surgery. Secondary outcomes were a composite of serious complications (myocardial infarction, cardiac arrest, stage 2-3 acute kidney injury [AKI], and mortality) and time to discharge alive...
March 22, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38517761/less-blood-pressure-but-not-less-aki-erratum
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 22, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38517760/society-for-ambulatory-anesthesia-updated-consensus-statement-on-perioperative-blood-glucose-management-in-adult-patients-with-diabetes-mellitus-undergoing-ambulatory-surgery
#12
JOURNAL ARTICLE
Niraja Rajan, Elizabeth W Duggan, Basem B Abdelmalak, Steven Butz, Leopoldo V Rodriguez, Mary Ann Vann, Girish P Joshi
WHAT OTHER GUIDELINES ARE AVAILABLE ON THIS TOPIC: Since the publication of the SAMBA Consensus Statement for perioperative blood glucose management in the ambulatory setting in 2010, several recent guidelines have been issued by the American Diabetes Association (ADA), the American Association of Clinical Endocrinologists (AACE), the Endocrine Society, the Centre for Perioperative Care (CPOC), and the Association of Anaesthetists of Great Britain and Ireland (AAGBI) on DM care in hospitalized patients; however, none are specific to ambulatory surgery...
March 22, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507557/evaluation-of-thrombin-and-plasmin-generation-velocity-ratios-during-progressive-plasma-dilution
#13
JOURNAL ARTICLE
Rui Terada, Yuko Mishima, BreAnna Le, Amir L Butt, Jerrold H Levy, Kenichi A Tanaka
No abstract text is available yet for this article.
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507554/involvement-of-spinal-neuroplastin-65-in-neuropathic-pain-by-gabaa-receptor-%C3%AE-2-subunit-regulation
#14
JOURNAL ARTICLE
Li Xu, Yu Wang, Yang Jiao, Yulin Huang, Rui Xu, Xiaoping Gu, Wei Zhang, Zhengliang Ma
BACKGROUND: Neuropathic pain (NP) is a highly challenging condition with complex pathological mechanisms, and the spinal gamma aminobutyric acid A receptor receptor plays a crucial role in its progression. Recent studies have revealed a potential interaction between neuroplastin 65 (NP65) and gamma aminobutyric acid A receptor α2 subunit (GABAAR-α2) on the cell surface. We hypothesize that NP65 is involved in the pathogenesis of NP by regulating the level of GABAAR-α2...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507523/anesthetic-sevoflurane-induces-enlargement-of-dendritic-spine-heads-in-mouse-neurons-via-tau-dependent-mechanisms
#15
JOURNAL ARTICLE
Jia Yan, Hoai Ton, Jing Yan, Yuanlin Dong, Zhongcong Xie, Hong Jiang
BACKGROUND: Sevoflurane induces neuronal dysfunction and cognitive impairment. However, the underlying mechanism remains largely to be determined. Tau, cyclophilin D, and dendritic spine contribute to cognitive function. But whether changes in dendritic spines are involved in the effects of sevoflurane and the potential association with tau and cyclophilin D is not clear. METHODS: We harvested hippocampal neurons from wild-type mice, tau knockout mice, and cyclophilin D knockout mice...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507520/james-watt-of-steam-engine-fame-offered-inhaled-carbon-monoxide-for-putative-therapeutic-action
#16
JOURNAL ARTICLE
Olivia W Xu, Jingping Wang, Theodore A Alston
James Watt (1736-1819) is remembered as a steam engine innovator and industrial magnate. A polymath, he was also a hands-on contributor to the Medical Pneumatic Institution of Thomas Beddoes. Watt recruited Humphry Davy, who there discovered analgesic action of inhaled nitrous oxide in 1799. Watt also built pneumatic equipment, and he introduced a gas mixture, dubbed hydro-carbonate, as a medical tonic. The bioactive component was carbon monoxide, a readily-lethal inhibitor of the transport and utilization of respiratory oxygen...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507503/abstracts-of-international-research-society-society-of-critical-care-anesthesiologists-2023-annual-meetings-erratum
#17
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38507476/brain-hazardous-medications-and-potential-subadequate-antidepressant-dosing-in-older-surgical-patients-receiving-home-antidepressants-an-observational-study-of-a-large-us-health-system
#18
JOURNAL ARTICLE
Bethany R Tellor Pennington, Katherine J Holzer, Bradley A Fritz, Simon Haroutounian, Kevin Y Xu, Amanda Tedder, Alex Kronzer, Michael S Avidan, Eric J Lenze
BACKGROUND: Older surgical patients with depression often experience poor postoperative outcomes. Poor outcomes may stem from brain-hazardous medications and subadequate antidepressant dosing. METHODS: This was a retrospective, observational cohort study covering the period between January 1, 2021 and December 31, 2021. Patients ≥60 years of age who underwent inpatient surgery and had an overnight stay at an integrated academic health care system comprising 14 hospitals were eligible...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38493440/persistent-opioid-use-after-hospital-admission-from-surgery-in-new-zealand-a-population-based-study
#19
JOURNAL ARTICLE
Jiayi Gong, Peter Jones, Chris Frampton, Kebede Beyene, Amy Hai Yan Chan
BACKGROUND: Persistent opioid use (POU) is common after surgery and is associated with an increased risk of mortality and morbidity. There have been no population-based studies exploring POU in opioid-naïve surgical patients in New Zealand (NZ). This study aimed to determine the incidence and risk factors for POU in opioid-naïve patients undergoing surgery in all NZ hospitals. METHOD: We included all opioid-naïve patients who underwent surgery without a concomitant trauma diagnosis and received opioids after discharge from any NZ hospital between January 2007 and December 2019...
March 18, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38478876/smallest-clinically-meaningful-improvement-in-amputation-related-pain-and-brief-pain-inventory-scores-as-defined-by-patient-reports-of-global-improvement-after-cryoneurolysis-a-retrospective-analysis-of-a-randomized-controlled-clinical-trial
#20
JOURNAL ARTICLE
Brian M Ilfeld, Cameron R Smith, Alparslan Turan, Edward R Mariano, Matthew E Miller, Rick L Fisher, Andrea M Trescot, Steven P Cohen, James C Eisenach, Daniel I Sessler, J David Prologo, Edward J Mascha, Liu Liu, Rodney A Gabriel
BACKGROUND: The smallest meaningful improvement in pain scores (minimal clinically important difference [MCID]) after an analgesic intervention is essential information when both interpreting published data and designing a clinical trial. However, limited information is available for patients with chronic pain conditions, and what is published is derived from studies involving pharmacologic and psychological interventions. We here calculate these values based on data collected from 144 participants of a previously published multicenter clinical trial investigating the effects of a single treatment with percutaneous cryoneurolysis...
March 14, 2024: Anesthesia and Analgesia
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