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American Journal of Transplantation

https://read.qxmd.com/read/38395150/pathophysiological-concepts-of-ischemia-reperfusion-injury-and-normothermic-ex-vivo-kidney
#41
LETTER
Jan H N Lindeman, Alexander F M Schaapherder
No abstract text is available yet for this article.
February 21, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38395149/defining-pre-emptive-living-kidney-donor-transplantation-as-a-quality-indicator
#42
JOURNAL ARTICLE
Carol Wang, Amit X Garg, Bin Luo, S Joseph Kim, Gregory Knoll, Seychelle Yohanna, Darin Treleaven, Susan McKenzie, Jane Ip, Rebecca Cooper, Lori Elliott, Kyla L Naylor
Quality indicators in kidney transplant are needed to identify care gaps and improve access to transplant. We used linked administrative healthcare databases to examine multiple ways of defining pre-emptive living donor kidney transplants, including different patient cohorts and censoring definitions. We included adults from Ontario, Canada with advanced chronic kidney disease between January 1, 2013 to December 31, 2018. We created four unique incident patient cohorts, varying the eligibility by risk of progression to kidney failure and whether individuals had a recorded contraindication to kidney transplant (e...
February 21, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38387623/geographic-disparities-in-access-to-liver-transplant-for-advanced-cirrhosis-time-to-ring-the-alarm
#43
JOURNAL ARTICLE
Jasmohan S Bajaj, Ashok Choudhury, Vinay Kumaran, Florence Wong, Wai Kay Seto, Mario Reis Alvares-Da-Silva, Hailemichael Desalgn, Peter C Hayes, Ramazan Idilman, Mark Topazian, Aldo Torre, Qing Xie, Jacob George, Patrick S Kamath
Decompensated cirrhosis and hepatocellular cancer (HCC) are major risk factors for mortality worldwide. Liver transplantation, both live-donor (LDLT) or deceased-donor (DDLT) are lifesaving but there are several barriers towards equitable access. These barriers are exacerbated in the setting of critical illness or acute-on-chronic liver failure (ACLF). Rates of LT vary widely worldwide but are lowest in lower-income countries due to lack of resources, infrastructure, late disease presentation, and limited donor awareness...
February 20, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38387622/the-hepatocyte-growth-factor-mimetic-ang-3777-in-kidney-transplant-recipients-with-delayed-graft-function-results-from-a-randomized-phase-3-trial
#44
JOURNAL ARTICLE
Flavio Vincenti, Jonathan Bromberg, Jim Kim, Arman Faravardeh, Nicolae Leca, Gabriela Alperovich, Philipp Andreas Csomor, Shakil Aslam, John Neylan
In kidney transplant recipients, delayed graft function (DGF) increases the risk of graft failure and mortality. In a phase 3, randomized, double-blind, placebo-controlled trial, we investigated the hepatocyte growth factor mimetic, ANG-3777 (once daily for 3 consecutive days, starting ≤30 hours posttransplant), in 248 patients receiving a first kidney transplant from a deceased donor. At day 360, estimated glomerular filtration rate (eGFR; primary endpoint) was not significantly different between the ANG-3777 and placebo groups...
February 20, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38387621/reply-to-angeletti-et-al-efficacy-of-combined-rituximab-and-daratumumab-treatment-in-posttransplant-recurrent-focal-segmental-glomerulosclerosis
#45
LETTER
Claire Dossier, Julien Hogan
No abstract text is available yet for this article.
February 20, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38387620/obesity-is-associated-with-a-higher-incidence-of-rejection-in-patients-on-belatacept-a-pooled-analysis-from-the-benefit-benefit-ext-clinical-trials
#46
JOURNAL ARTICLE
Nicholas W Lange, Kristen King, Syed Ali Husain, David M Salerno, Demetra S Tsapepas, Jessica Hedvat, Miko Yu, Sumit Mohan
Though belatacept is administered with a weight-based dosing schema, there has been higher clearance reported in obese patients. Therefore, we evaluated the association between BMI and transplant outcomes in kidney transplant recipients who were randomized to cyclosporine- or belatacept-based immunosuppression in the BENEFIT and BENEFIT-EXT randomized clinical trials. A total of 666 and 543 patients underwent randomization and transplantation in BENEFIT and BENEFIT-EXT, respectively, of which 1,056 had complete data and were included in this analysis...
February 20, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38387619/outcomes-in-solid-organ-transplant-recipients-with-a-pretransplant-diagnosis-of-melanoma
#47
JOURNAL ARTICLE
Fiona O Zwald, Michael R Sargen, April A Austin, Mei-Chin Hsieh, Karen Pawlish, Jie Li, Charles F Lynch, Kelly J Yu, Eric A Engels
Melanoma causes significant morbidity in solid organ transplant recipients (SOTRs). Melanomas diagnosed before transplantation can recur with intensive immunosuppression, but outcomes have not been well studied. We evaluated 901 non-Hispanic White SOTRs with a pretransplant melanoma identified using linked transplant and cancer registry data in the United States. Most pretransplant melanomas were invasive (60.7%), and the median time from diagnosis to transplantation was 5.1 years. After transplantation, 41 SOTRs developed a new invasive melanoma, corresponding to 9-fold increased risk compared with the general population (standardized incidence ratio, 9...
February 20, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38373523/updated-2024-us-vaccine-recommendations-from-the-advisory-committee-on-immunization-practices-acip
#48
JOURNAL ARTICLE
Marcus R Pereira
No abstract text is available yet for this article.
February 17, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38364959/inflammatory-and-hypoxic-stress-induced-islet-exosomes-released-during-isolation-are-associated-with-poor-transplant-outcomes-in-islet-autotransplantation
#49
JOURNAL ARTICLE
Prathab Balaji Saravanan, Jagan Kalivarathan, Kaeden McClintock, Shujauddin Mohammed, Elijah Burch, Christiane Morecock, Jinze Liu, Aamir Khan, Marlon F Levy, Mazhar A Kanak
Islets experience enormous stress during the isolation process, leading to suboptimal endocrine function after total pancreatectomy with islet autotransplantation (TPIAT). Our investigation focused on inducing isolation stress in islets ex vivo, where proinflammatory cytokines and hypoxia prompted the release of stress exosomes (exoS ) sized between 50-200nm. Mass spectrometry analysis revealed three distinct subgroups of immunogenic proteins within these exoS : damage-associated molecular patterns (DAMPs), chaperones, and autoantigens...
February 14, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38360185/the-impact-of-time-to-death-in-donors-after-circulatory-death-on-recipient-outcome-in-simultaneous-pancreas-kidney-transplantation
#50
JOURNAL ARTICLE
Abdullah K Malik, Samuel J Tingle, Nicholas Chung, Ruth Owen, Balaji Mahendran, Claire Counter, Sanjay Sinha, Anand Muthasamy, Andrew Sutherland, John Casey, Martin Drage, David van Dellen, Chris J Callaghan, Doruk Elker, Derek M Manas, Gavin J Pettigrew, Colin H Wilson, Steven A White
Time to arrest in donors after circulatory death is unpredictable and can vary. This leads to variable periods of warm ischaemic damage prior to pancreas transplantation. There is little evidence supporting procurement team stand-down times based on donor time to death (TTD). We examined what impact TTD had on pancreas graft outcomes following DCD SPK transplantation. Data were extracted from the UK transplant registry from 2014 to 2022. Predictors of graft loss were evaluated by a Cox proportional hazards model...
February 13, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38346500/-horses-for-courses-computed-tomography-or-predicted-total-lung-capacity-for-size-matching-in-lung-transplantation
#51
JOURNAL ARTICLE
James D McMenimen, Jason M Gauthier, Varun Puri, Rodrigo Vazquez Guillamet
Size matching donors to recipients in lung transplantation continues to be a clinical challenge. Predicted total lung capacity equations or more simply donor and recipient heights, while widely used, are imprecise and may not be representative of the pool of donors and recipients. These inherent limitations may result in size discrepancies. The advent of easily accessible software and widespread availability of computed tomography imaging in donor assessments, has made it possible to directly measure lung volumes in donors and recipients...
February 10, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38346499/characterizing-proximity-and-transfers-of-deceased-organ-donors-to-donor-care-units-in-the-united-states
#52
JOURNAL ARTICLE
Emily A Vail, Vicky W Tam, Elizabeth M Sonnenberg, Nikhil R Lavu, Peter P Reese, Peter L Abt, Niels D Martin, Richard D Hasz, Kim D Olthoff, Meeta P Kerlin, Jason D Christie, Mark D Neuman, Vishnu S Potluri
Some United States organ procurement organizations transfer deceased organ donors to donor care units (DCUs) for recovery procedures. We used Organ Procurement and Transplantation Network data, April 2017 - June 2021, to describe the proximity of adult deceased donors after brain death to DCUs and understand the impact of donor service area (DSA) boundaries on transfer efficiency. Among 19,109 donors (56.1% of cohort) in 25 DSAs with DCUs, a majority (14,593 (76.4%)) were in hospitals within a two-hour drive...
February 10, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38346498/where-you-live-matters-area-deprivation-predicts-poor-survival-and-liver-transplant-waitlisting
#53
JOURNAL ARTICLE
Bima J Hasjim, Alexander A Huang, Mitchell Paukner, Praneet Polineni, Alexandra Harris, Mohsen Mohammadi, Kiarri N Kershaw, Therese Banea, Lisa B VanWagner, Lihui Zhao, Sanjay Mehrotra, Daniela P Ladner
Social determinants of health (SDOH) are important predictors of poor clinical outcomes in chronic diseases, but their associations among the general cirrhosis population and liver transplantation (LT) are limited. We conducted a retrospective, multiinstitutional analysis of adult (≥18-years-old) patients with cirrhosis in metropolitan Chicago to determine the associations of poor neighborhood-level SDOH on decompensation complications, mortality, and LT waitlisting. Area deprivation index and covariates extracted from the American Census Survey were aspects of SDOH that were investigated...
February 10, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38346497/immunopathogenesis-of-acute-on-chronic-liver-failure
#54
JOURNAL ARTICLE
Artru Florent, Mark J McPhail
Acute-on-chronic liver failure is a well-established description of a high mortality syndrome of chronic liver disease (usually cirrhosis) with organ failure. While the exact definition is under refinement the accepted understanding of this entity is in patients with chronic liver disease who have various organs in failure and where systemic inflammation is a major component of the pathobiology. There are limited therapies for a disease with such a poor prognosis and while improvements in the critical care management and for very few patients, liver transplantation, mean 50% can survive to hospital discharge, rapid application of new therapies is required...
February 10, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38342183/donor-derived-carbapenem-resistant-gram-negative-bacterial-infections-in-solid-organ-transplant-recipients-active-surveillance-enhances-recipient-safety
#55
JOURNAL ARTICLE
Alessandra Mularoni, Andrea Cona, Maria Campanella, Floriana Barbera, Alice Annalisa Medaglia, Adriana Cervo, Nicola Cuscino, Giuseppina Di Mento, Elena Graziano, Jana Dib El Jalbout, Rossella Alduino, Fabio Tuzzolino, Francesco Monaco, Antonio Cascio, Maddalena Peghin, Salvatore Gruttadauria, Alessandro Bertani, Pier Giulio Conaldi, Malgorzata Mikulska, Paolo Antonio Grossi
Donor-derived infections (DDI) sustained by carbapenem-resistant gram-negative bacteria (CR-GNB) in solid organ transplant recipients are potentially life-threatening. In this prospective study, we evaluate the incidence, factors associated with transmission, and the outcome of recipients with unexpected CR-GNB DDI after the implementation of our local active surveillance system (LASS). LASS provides for early detection of unexpected donor CR-GNB infections, prophylaxis of recipients at high-risk, and early diagnosis and treatment of DDI...
February 9, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38341028/the-rsv-vaccines-are-here-implications-for-solid-organ-transplantation
#56
REVIEW
Paul Trubin, Marwan M Azar, Camille N Kotton
In 2023, the Food and Drug Administration approved two recombinant subunit RSV vaccines based on prefusion RSV F glycoproteins for the prevention of RSV-associated lower respiratory tract disease. These vaccines were subsequently recommended for individuals ≥60 years of age using shared clinical decision-making by the Center for Disease Control and Prevention's Advisory Committee on Immunization Practices. The development, deployment, and uptake of respiratory virus vaccines are of particular importance for solid organ recipients who are at higher risk of infectious complications and poor clinical outcomes, including from RSV-associated lower respiratory tract disease, compared to patients without immunocompromise...
February 8, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38341027/recurrence-of-membranous-nephropathy-after-kidney-transplantation-a-multicenter-retrospective-cohort-study
#57
JOURNAL ARTICLE
Frank Hullekes, Audrey Uffing, Rucháma Verhoeff, Harald Seeger, Seraina von Moos, Juliana Mansur, Gianna Mastroianni-Kirsztajn, Helio Tedesco Silva, Anna Buxeda, María José Pérez-Sáez, Carlos Arias-Cabrales, A Bernard Collins, Christie Swett, Leela Morená, Marina Loucaidou, Andreas Kousios, Paolo Malvezzi, Mathilde Bugnazet, Luis Sanchez Russo, Saif A Muhsin, Nikhil Agrawal, Pitchaphon Nissaisorakarn, Het Patel, Ayman Al Jurdi, Enver Akalin, Elias David Neto, Fabiana Agena, Carlucci Ventura, Roberto C Manfro, Andrea Carla Bauer, Marilda Mazzali, Marcos Vinicius de Sousa, Gaetano La Manna, Claudia Bini, Giorgia Comai, Roman Reindl-Schwaighofer, Stefan Berger, Paolo Cravedi, Leonardo V Riella
Membranous nephropathy (MN) is a leading cause of kidney failure worldwide, and frequently recurs after transplant. Available data originated from small retrospective cohort studies or registry analyses. Therefore, uncertainties remain on risk factors for MN recurrence and response to therapy. Within the Post-Transplant Glomerular Disease (TANGO) Consortium, we conducted a retrospective multicenter cohort study examining the MN recurrence rate, risk factors, and response to treatment. This study screened 22,921 patients across three continents and included 194 patients who underwent a kidney transplant due to biopsy-proven MN...
February 8, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38341026/the-decedent-model-a-new-paradigm-for-de-risking-high-stakes-clinical-trials-like-xenotransplantation
#58
JOURNAL ARTICLE
Robert A Montgomery, Adam D Griesemer, Dorry L Segev, Philip Sommer
The first two living recipients of pig hearts died unexpectedly within two months, despite both recipients receiving what over 30 years of nonhuman primate (NHP) research would suggest were the optimal gene edits and immunosuppression to ensure success. These results prompt us to question how faithfully data from the NHP model translates into human outcomes. Before attempting any further heart xenotransplants in living humans, it is highly advisable to gain a more comprehensive understanding of why the promising pre-clinical NHP data did not accurately predict outcomes in humans...
February 8, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38341025/neutralizing-antibodies-as-key-players-in-preventing-bk-polyomavirus-replication-insights-from-bench-to-bedside
#59
LETTER
Ilies Benotmane, Sophie Caillard, Samira Fafi-Kremer, Morgane Solis
No abstract text is available yet for this article.
February 8, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38331047/genetic-versus-self-reported-african-ancestry-of-the-recipient-and-neighborhood-predictors-of-kidney-transplantation-outcomes-in-two-multiethnic-urban-cohorts
#60
JOURNAL ARTICLE
Francesca Zanoni, Y Dana Neugut, Joy E Obayemi, Lili Liu, Jun Y Zhang, Lloyd E Ratner, David J Cohen, Sumit Mohan, Ali G Gharavi, Brendan Keating, Krzysztof Kiryluk
African American (AA) kidney recipients have a higher risk of allograft rejection and failure compared to non-AAs, but to what extent these outcomes are due to genetic versus environmental effects is currently unknown. Herein, we tested the effects of recipient self-reported race versus genetic African admixture proportion (pAFR) and neighborhood socioeconomic status (SES) on kidney allograft outcomes in multiethnic kidney transplant recipients from Columbia University (N=1,083) and the University of Pennsylvania (N=738)...
February 6, 2024: American Journal of Transplantation
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