Use the journals feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Seokjoo Lee, Tomas Blanco, Aytan Musayeva, Shima Dehghani Ahmadabad, Akitomo Narimatsu, Katayoon Forouzanfar, Gustavo Ortiz, Francesca Kahale, Shudan Wang, Yihe Chen, Thomas H Dohlman, Sunil K Chauhan, Reza Dana
Highly inflamed and neovascularized corneal graft beds are known as high-risk environments for transplant survival. One of the primary factors leading to this rejection is reduction in the suppressive function of regulatory T cells (Treg). Our results show that myeloid-derived suppressor cells (MDSC) counteract IL-6-mediated Treg dysfunction by expressing IL-10. Additionally, MDSC maintain FoxP3 stability and their ability to suppress IFN-γ+ Th1 cells. Administering MDSC to high-risk corneal transplant recipients demonstrates prolonged graft survival via promotion of Treg while concurrently suppressing IFN-γ+ Th1 cells...
March 19, 2024: American Journal of Transplantation
#22
JOURNAL ARTICLE
Kiran K Khush, James L Bernat, Richard N Pierson, Henry J Silverman, Brendan Parent, Alexandra K Glazier, Andrew B Adams, Jay A Fishman, Michael Gusmano, Wayne J Hawthorne, Mary E Homan, Daniel J Hurst, Stephen Latham, Chung-Gyu Park, Karen J Maschke, Muhammad M Mohiuddin, Robert A Montgomery, Jonah Odim, Rebecca D Pentz, Bruno Reichart, Julian Savulescu, Paul Root Wolpe, Renee P Wong, Kathleen N Fenton
Xenotransplantation offers the potential to meet the critical need for heart and lung transplantation presently constrained by the current human donor organ supply. Much was learned over the past decades regarding gene editing to prevent the immune activation and inflammation that cause early organ injury, and strategies for maintenance of immunosuppression to promote longer-term xenograft survival. However, many scientific questions remain regarding further requirements for genetic modification of donor organs, appropriate contexts for xenotransplantation research (including nonhuman primates, recently deceased humans, and living human recipients), and risk of xenozoonotic disease transmission...
March 19, 2024: American Journal of Transplantation
#23
EDITORIAL
Alessandro Alessandrini, Ivy A Rosales
No abstract text is available yet for this article.
March 18, 2024: American Journal of Transplantation
#24
EDITORIAL
Yasar Caliskan, Krista L Lentine
No abstract text is available yet for this article.
March 18, 2024: American Journal of Transplantation
#25
EDITORIAL
Montserrat Kwan, Maria-Luisa Alegre
No abstract text is available yet for this article.
March 18, 2024: American Journal of Transplantation
#26
JOURNAL ARTICLE
Canizares Stalin, Montalvan Adriana, Chumdermpadetsuk Ritah, Modest Anna, Eckhoff Devin, Lee David
The imbalance between organ supply and demand continues to limit the broader benefits of organ transplantation. Machine perfusion (MP) may increase the supply of donor livers by expanding the use of extended criteria donors (ECDs). Using the UNOS/OPTN STAR dataset we reviewed the effect of MP implementation on the behavior of transplant centers. We identified 15 high-utilizing MP centers that were matched to suitable controls based on volume and geographical proximity. We conducted a Differences-in-Differences analysis using linear regression to estimate the impact of MP adoption on the transplant centers' donor utilization...
March 18, 2024: American Journal of Transplantation
#27
JOURNAL ARTICLE
Ronald F Parsons, Krista L Lentine, Mona Doshi, Ty B Dunn, Rachel Forbes, Jonathan A Fridell, Michelle T Jesse, Martha Pavlakis, Deirdre Sawinski, Neeraj Singh, David A Axelrod, Matthew Cooper
In the United States, potential transplant candidates with insulin-dependent diabetes mellitus are inconsistently offered pancreas transplantation, contributing to a dramatic decline in pancreas allograft utilization over the past two decades. The American Society of Transplantation (AST) organized a workshop to identify barriers inhibiting pancreas transplantation and to develop strategies for a national comeback. The two-day workshop focused on four main topics: (1) referral/candidate selection, (2) organ recovery/utilization, (3) program performance/patient outcomes, (4) enhanced education/research...
March 16, 2024: American Journal of Transplantation
#28
JOURNAL ARTICLE
Marcus R Pereira
No abstract text is available yet for this article.
March 16, 2024: American Journal of Transplantation
#29
JOURNAL ARTICLE
Javier T Solera, Berta G Árbol, Ankit Mittal, Victoria Hall, Tina Marinelli, Ilona Bahinskaya, Nazia Selzner, Michael McDonald, Jeffrey Schiff, Aman Sidhu, Atul Humar, Deepali Kumar
Data regarding COVID-19 outcomes in solid organ transplant recipients(SOTr) across SARS-CoV-2 waves, including the impact of different measures, is lacking. This cohort study, conducted from March 2020-May 2023 in Toronto, Canada, aimed to analyze COVID-19 outcomes in 1,975 SOTr across various SARS-CoV-2 waves and assess the impact of preventive and treatment measures. The primary outcome was severe COVID-19, defined as requiring supplemental oxygen, with secondary outcomes including hospitalization, length of stay, ICU admission, and 30-day and 1-year all-cause mortality...
March 16, 2024: American Journal of Transplantation
#30
JOURNAL ARTICLE
Daan Kremer, Tim J Knobbe, Joanna Sophia J Vinke, Dion Groothof, Adrian Post, Coby Annema, Alferso C Abrahams, Brigit C van Jaarsveld, Martin H de Borst, Stefan P Berger, Stephan J L Bakker, Michele F Eisenga
Kidney transplant recipients (KTRs) experience more fatigue, anxiety and depressive symptoms, and lower concentration and health-related quality of life (HRQoL) compared to the general population. Anemia is a potential cause that is well-recognized and treated. Iron deficiency, however, is often unrecognized, despite its potential detrimental effects related and unrelated to anemia. We investigated the interplay of anemia, iron deficiency and patient-reported outcomes (PROs) in 814 outpatient KTRs (62% male, age 56±13 years) enrolled in the TransplantLines Biobank and Cohort Study (Groningen, The Netherlands)...
March 15, 2024: American Journal of Transplantation
#31
REVIEW
Markus J Barten, Andrew Fisher, Alexandre Hertig
Prevention and management of allograft rejection urgently require more effective therapeutic solutions. Current immunosuppressive therapies used in solid organ transplantation, while effective in reducing the risk of acute rejection, are associated with substantial adverse effects. There is therefore a need for agents that can provide immunomodulation supporting graft tolerance, while minimizing the need for immunosuppression. Extracorporeal photopheresis (ECP) is an immunomodulatory therapy currently recommended in international guidelines as an adjunctive treatment for the prevention and management of organ rejection in heart (HTx) and lung (LTx) transplantation...
March 13, 2024: American Journal of Transplantation
#32
JOURNAL ARTICLE
James F Markmann, Bryna E Burrell, Jonathan S Bromberg, Choli Hartono, Dixon B Kaufman, Andrew M Possselt, Ali Naji, Nancy D Bridges, Cynthia Breeden, Sai Kanaparthi, Jorge Pardo, Heather Kopetskie, Kristen Mason, Noha Lim, Sindhu Chandran
Durable tolerance in kidney transplant recipients remains an important but elusive goal. We hypothesized that adding B cell depletion to T cell depletion would generate an immune milieu postreconstitution dominated by immature transitional B cells, favoring tolerance. The Immune Tolerance Network ITN039ST Research Study of ATG and Rituximab in Renal Transplantation was a prospective multicenter pilot study of live donor kidney transplant recipients who received induction with rabbit antithymocyte globulin and rituximab and initiated immunosuppression (IS) withdrawal (ISW) at 26 weeks...
March 11, 2024: American Journal of Transplantation
#33
JOURNAL ARTICLE
Christopher O C Bellamy, Jacqueline G O'Leary, Oyedele Adeyi, Nahed Baddour, Ibrahim Batal, John Bucuvalas, Arnaud Del Bello, Mohamed El Hag, Magda El-Monayeri, Alton B Farris, Sandy Feng, Maria Isabel Fiel, Sandra E Fischer, John Fung, Krzysztof Grzyb, Maha Guimei, Hironori Haga, John Hart, Annette M Jackson, Elmar Jaeckel, Nigar A Khurram, Stuart J Knechtle, Drew Lesniak, Josh Levitsky, Geoff McCaughan, Catriona McKenzie, Claudia Mescoli, Rosa Miquel, Marta I Minervini, Imad Ahmad Nasser, Desley Neil, Maura F O'Neil, Orit Pappo, Parmjeet Randhawa, Phillip Ruiz, Alberto Sanchez Fueyo, Deborah Schady, Thomas Schiano, Mylene Sebagh, Maxwell Smith, Heather L Stevenson, Timucin Taner, Richard Taubert, Swan Thung, Pavel Trunecka, Hanlin L Wang, Michelle Wood-Trageser, Funda Yilmaz, Yoh Zen, Adriana Zeevi, Anthony J Demetris
The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term allograft health, including non-invasive and tissue monitoring, immunosuppression optimisation and long-term structural changes. Potential revision of the rejection classification scheme to better accommodate and communicate late T cell-mediated rejection patterns and related structural changes, such as nodular regenerative hyperplasia, were discussed...
March 8, 2024: American Journal of Transplantation
#34
LETTER
Ayelet Shai
No abstract text is available yet for this article.
March 8, 2024: American Journal of Transplantation
#35
LETTER
Eytan Mor
No abstract text is available yet for this article.
March 8, 2024: American Journal of Transplantation
#36
Charlotte Roy, Nathalie Allou, Aurore Coulomb, Dominique Grenet, Raphaël Borie, Benjamin Zuber, Abdulmonem Hamid, Matthieu Glorion, Anne-Laure Brun, Elizabeth Longchamps, Alice Hadchouel, Olivier Brugiere
Pulmonary alveolar proteinosis (PAP) results from the accumulation of lipoproteinaceous material in the alveoli and alveolar macrophages, and can be associated with pulmonary fibrosis (PAP-PF), with a need for lung transplantation (LTx). Causes of PAP are autoimmune (90-95%), secondary (5%), or hereditary (<1%). Patients with hereditary PAP are generally not considered for isolated LTx, due to the high probability of recurrence after LTx, and only a challenging scenario with sequential LTx followed by HSCT was reported as successful...
March 8, 2024: American Journal of Transplantation
#37
JOURNAL ARTICLE
Ivan Zahradka, Filip Tichanek, Maria Magicova, Istvan Modos, Ondrej Viklicky, Vojtech Petr
Although SARS-CoV-2 mRNA vaccines are effective in kidney transplant recipients (KTRs), their immune response to vaccination is blunted by immunosuppression. Other tools enhancing vaccination response are therefore needed. Interestingly, aligning vaccine administration with circadian rhythms (chronovaccination) was shown to boost immune response. However, its applicability in KTRs, whose circadian rhythms are likely disrupted by immunosuppressants, remains unclear. To assess the impact of vaccination timing on seroconversion in KTRs population, we analyzed data from 553 virus-naïve KTRs who received two doses of mRNA vaccines...
March 7, 2024: American Journal of Transplantation
#38
JOURNAL ARTICLE
Linea Landgrebe Ring, Helle Kiellberg Larsen, Kirsten Frederiksen, Merete Hædersdal, Søren Schwartz Sørensen, Jesper Hansen Bonde, Louise Thirstrup Thomsen, Susanne K Kjær
This study investigates the incidence and clearance of cervical and anal high-risk human papillomavirus (hrHPV) infection in kidney transplant recipients (KTRs) compared to immunocompetent controls. During 2016-2017, we enrolled 125 female KTRs and 125 female controls. Liquid-based cervical and anal cytology samples collected at enrollment and follow-up were tested for human papillomavirus (HPV) DNA using the CLART HPV2 test. All participants answered a questionnaire on lifestyle and sexual behavior at both examinations...
March 6, 2024: American Journal of Transplantation
#39
JOURNAL ARTICLE
Sarah E Booker, Katrina Gauntt, Jesse Howell, Joann White, Oyedolamu Olaitan, Rachel C Forbes
On 3/15/2021, the Organ Procurement and Transplantation Network (OPTN) replaced donation service area (DSA) and OPTN region as units of pancreas (PA) allocation with a 250 nautical mile (NM) circle with proximity points. We analyzed OPTN data for kidney-pancreas (KP) and PA candidates, transplants, and donors in the 2 years pre- (3/16/2019-3/14/2021) and post-policy (3/15/2021-3/14/2023). As expected, more transplants occurred at hospitals outside the recovering OPO's DSA post-policy (KP: 32.1% vs 57.3%, p<0...
March 6, 2024: American Journal of Transplantation
#40
JOURNAL ARTICLE
Di Zhang, Wei Lv, Yue Xu, Zijian Zhang, Song Zeng, Weixun Zhang, Lian Gong, Limei Shao, Min Zhang, Tian He, Yingying Liu, Yuxuan Wang, Ling Liu, Xiaopeng Hu
Mycophenolate mofetil (MMF) is one of the most used immunosuppressive drugs in organ transplantation, but frequent gastrointestinal (GI) side effects through unknown mechanisms limit its clinical use. Gut microbiota and its metabolites were recently reported to play a vital role in MMF-induced GI toxicity, but the specific mechanism of how they interact with the human body is still unclear. Here, we found that secondary bile acids (BAs), as bacterial metabolites, were significantly reduced by MMF administration in the gut of mice...
March 5, 2024: American Journal of Transplantation
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
