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JOURNAL ARTICLE
Peter W Schreiber, Linard D Hoessly, Katia Boggian, Dionysios Neofytos, Christian van Delden, Adrian Egli, Michael Dickenmann, Cédric Hirzel, Oriol Manuel, Michael Koller, Simona Rossi, Vanessa Banz, Bruno Schmied, Lorenz Guerke, Maurice Matter, Olivier de Rougemont, Marco Bonani, Déla Golshayan, Aurelia Schnyder, Daniel Sidler, Fadi Haidar, Stefan P Kuster, Susanne Stampf, Nicolas J Mueller
Surgical site infections (SSI) are common healthcare-associated infections. SSIs after kidney transplantation (K-Tx) can endanger patient and allograft survival. Multicenter studies on this early post-transplant complication are scarce. We analyzed consecutive adult K-Tx recipients enrolled in the Swiss Transplant Cohort Study (STCS) that received a K-tx between May 2008 and September 2020. All data were prospectively collected with the exception of the categorization of SSI that was performed retrospectively according to the Centers for Disease Control and Prevention criteria...
November 30, 2023: American Journal of Transplantation
#2
JOURNAL ARTICLE
Samson Hennessy-Strahs, Xian C Li
No abstract text is available yet for this article.
November 24, 2023: American Journal of Transplantation
#3
JOURNAL ARTICLE
Lara C Pullen
No abstract text is available yet for this article.
November 21, 2023: American Journal of Transplantation
#4
LETTER
Christopher Bobier, Daniel Rodger, Daniel J Hurst
No abstract text is available yet for this article.
November 21, 2023: American Journal of Transplantation
#5
JOURNAL ARTICLE
Steven J Hiho, Bronwyn J Levvey, Mary B Diviney, Gregory I Snell, Lucy C Sullivan, Glen P Westall
Outcomes following lung transplantation (LTx) remain poor, despite advances in sequencing technology and development of algorithms defining immunological compatibility. Presently, there is no consensus regarding the best approach to define HLA compatibility in LTx. Here, we compared five different HLA compatibility tools in a high-resolution HLA typed, clinically characterized cohort, to determine which approach predicts outcomes following LTx. In this retrospective single-center study, 277 donor-recipient transplant pairs were HLA typed by Next Generation Sequencing (NGS)...
November 17, 2023: American Journal of Transplantation
#6
JOURNAL ARTICLE
Mariam P Alexander, Mark Zaidi, Nicholas B Larson, Aidan Muller, Kevin Pavelko, Mark Stegall, Andrew Bentall, Bradly G Wouters, Trevor D McKee, Timucin Taner
Kidney allograft inflammation, mostly attributed to rejection and infection, is an important cause of graft injury and loss. Standard histopathological assessment of allograft inflammation provides limited insights into biological processes and immune landscape. Here, using Imaging Mass Cytometry (IMC) with a panel of 28 validated biomarkers, we explored the single-cell landscape of kidney allograft inflammation in 32 kidney transplant biopsies and 247 high-dimensional histopathology images of various phenotypes of allograft inflammation (antibody-mediated rejection, T cell-mediated rejection, BK nephropathy and chronic pyelonephritis)...
November 16, 2023: American Journal of Transplantation
#7
JOURNAL ARTICLE
Noriaki Sato, Atsuko Shiraki, Keita P Mori, Kaoru Sakai, Yoshinori Takemura, Motoko Yanagita, Seiya Imoto, Kazunari Tanabe, Kimiyasu Shiraki
BK polyomavirus (BKPyV) infection causes various diseases in immunocompromised patients. Cells from human lung and kidney were infected with BKPyV and treated with commercially available intravenous immunoglobulin G (IVIG). Its effects on BKPyV replication and spread of infection were investigated, focusing on administration timing. IVIG treatment 3 h after infection suppressed BKPyV replication assessed by real-time PCR and expression of the VP1 capsid protein and large T-antigen. IVIG effectively reduced the number of BKPyV-infected cells 2 weeks after infection in an antibody titer-dependent manner...
November 15, 2023: American Journal of Transplantation
#8
JOURNAL ARTICLE
Emily Cerier, Chitaru Kurihara, Taisuke Kaiho, Takahide Toyoda, Adwaiy Manerikar, Viswajit Kandula, Benjamin Thomae, Yuriko Yagi, Anjana Yeldandi, Samuel Kim, Diego Avella-Patino, John Pandolfino, Harris Perlaman, Benjamin Singer, G R Scott Budinger, Kalvin Lung, Borislav Alexiev, Ankit Bharat
Growing evidence implicates complement in the pathogenesis of primary graft dysfunction (PGD). We hypothesized that early complement activation post-reperfusion could predispose to severe PGD grade 3 (PGD-3) at 72 hours that is associated with worst post-transplant outcomes. Consecutive lung transplant patients (n=253) from January 2018 through June 2023 underwent timed open allograft biopsies at the end of cold ischemia (internal control) and 30 minutes post-reperfusion. PGD-3 at 72 hours occurred in 14% (35/253) of patients, 17% (44/253) revealed positive C4d staining on post-reperfusion allograft biopsy, and no biopsy related complications were encountered...
November 15, 2023: American Journal of Transplantation
#9
JOURNAL ARTICLE
Seyed M Hosseini-Moghaddam, Sagar Kothari, Atul Humar, Hanan Albasata, Zachary A Yetmar, Raymund R Razonable, Dionysios Neofytos, Matilde D'Asaro, Katia Boggian, Cedric Hirzel, Nina Khanna, Oriol Manuel, Nicolas J Mueller, Hannah Imlay, Dima Kabbani, Varalika Tyagi, Olivia C Smibert, Mohamed Nasra, Lauren Fontana, Karam M Obeid, Anna Apostolopoulou, Sean X Zhang, Nitipong Permpalung, Hind Alhatimi, Michael S Silverman, Henry Guo, Benjamin A Rogers, Erica MacKenzie, Jennifer Pisano, Francesca Gioia, Lindita Rapi, G V Ramesh Prasad, Marcela Banegas, Carolyn D Alonso, Kathleen Doss, Robert M Rakita, Jay A Fishman
Solid organ transplant recipients (SOTRs) frequently receive adjunctive glucocorticoid therapy (AGT) for Pneumocystis jirovecii pneumonia (PJP). This multicenter cohort of SOTRs with PJP admitted to 20 transplant centers in Canada, the United States, Europe, and Australia, examined whether AGT was associated with a lower rate of all-cause intensive care unit (ICU) admission, 90-day in-hospital death, or a composite outcome (ICU admission or death). Of 172 SOTRs with PJP [median (IQR) age: 60 (51.5-67.0) years, 58 female (33...
November 15, 2023: American Journal of Transplantation
#10
JOURNAL ARTICLE
Semi-Directed Living Donors in Israel: Socio-Demographic Profile, Religiosity, and Social Tolerance.
Eviatar Nesher, Rachel Michowiz, Hagai Boas
No abstract text is available yet for this article.
November 15, 2023: American Journal of Transplantation
#11
JOURNAL ARTICLE
Evelien E Quint, Yi Liu, Omid Shafaat, Nidhi Ghildayal, Helen Crosby, Arun Kamireddy, Robert A Pol, Babak J Orandi, Dorry L Segev, Clifford Weiss, Mara A McAdams DeMarco
Body mass index (BMI) is often used to determine kidney transplant (KT) candidacy. However, this measure of body composition has several limitations, including the inability to accurately capture dry weight. Objective computed tomography (CT)-based measures may improve pre- KT risk stratification and capture physiologic aging more accurately. We quantified the association between CT-based body composition measurements and waitlist mortality in a retrospective study of 828 KT candidates (2010-2022) with clinically obtained CT scans using adjusted competing risk regression...
November 8, 2023: American Journal of Transplantation
#12
JOURNAL ARTICLE
William A Preston, Devon J Pace, Peter J Altshuler, Misung Yi, Haley Kittle, Sage Vincent, Kenneth Andreoni, Adam M Frank, Jaime M Glorioso, Carlo Ramirez, Warren R Maley, Ashesh P Shah, Adam S Bodzin
The recent shortage of University of Wisconsin (UW) solution prompted increased utilization of histidine-tryptophan-ketoglutarate (HTK) solution for liver graft preservation. This contemporary study analyzed deceased donor liver transplant outcomes following preservation with HTK vs. UW. Patients receiving deceased donor liver transplantations between 1/1/2019 and 6/30/2022 were retrospectively identified utilizing the Organ Procurement and Transplant Network database, stratified by preservation with HTK vs...
November 6, 2023: American Journal of Transplantation
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JOURNAL ARTICLE
Candice Roufosse, Maarten Naesens, Mark Haas, Carmen Lefaucheur, Roslyn B Mannon, Marjan Afrouzian, Nada Alachkar, Olivier Aubert, Serena M Bagnasco, Ibrahim Batal, Chris O C Bellamy, Verena Broecker, Klemens Budde, Marian Clahsen-Van Groningen, Shana M Coley, Lynn D Cornell, Darshana Dadhania, Anthony J Demetris, Gunilla Einecke, Alton B Farris, Agnes B Fogo, John Friedewald, Ian W Gibson, Catherine Horsfield, Edmund Huang, Syed A Husain, Annette M Jackson, Jesper Kers, Željko Kikić, Amanda Klein, Nicolas Kozakowski, Helen Liapis, Massima Mangiola, Robert A Montgomery, Brian Nankinvell, Desley A H Neil, Peter Nickerson, Marion Rabant, Parmjeet Randhawa, Leonardo V Riella, Ivy Rosales, Virginie Royal, Ruth Sapir-Pichhadze, Pinaki Sarder, Minnie Sarwal, Carrie Schinstock, Mark Stegall, Kim Solez, Jeroen van der Laak, Chris Wiebe, Robert B Colvin, Alexandre Loupy, Michael Mengel
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to a key focus on the impact of microvascular inflammation and biopsy-based transcript analysis on the Banff Classification, further sessions were devoted to other aspects of kidney transplant pathology, in particular T cell-mediated rejection, activity and chronicity indices, digital pathology, xenotransplantation, clinical trials, and surrogate endpoints...
November 4, 2023: American Journal of Transplantation
#14
LETTER
Chitaru Kurihara, Taisuke Kaiho, Ankit Bharat
No abstract text is available yet for this article.
November 4, 2023: American Journal of Transplantation
#15
JOURNAL ARTICLE
Elizabeth N Pavlisko, Benjamin A Adam, Gerald J Berry, Fiorella Calabrese, Nahir Cortes-Santiago, Carolyn H Glass, Martin Goddard, John R Greenland, Daniel Kreisel, Deborah J Levine, Tereza Martinu, Stijn E Verleden, Weigt S Sam, Antoine Roux
The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference - held in Banff, Alberta - focused on non-rejection lung allograft pathology and novel technologies for the detection of allograft injury. A multidisciplinary panel reviewed the state-of-the-art of current histopathologic entities, serologic studies, and molecular practices, as well as novel applications of digital pathology with artificial intelligence, gene expression analysis, and quantitative image analysis of chest computerized tomography...
November 4, 2023: American Journal of Transplantation
#16
LETTER
Alessandro Alessandrini
No abstract text is available yet for this article.
November 4, 2023: American Journal of Transplantation
#17
EDITORIAL
Enver Akalin, Valeria R Mas
No abstract text is available yet for this article.
November 2, 2023: American Journal of Transplantation
#18
JOURNAL ARTICLE
Charles G Rickert, James M Gardner
No abstract text is available yet for this article.
November 2, 2023: American Journal of Transplantation
#19
JOURNAL ARTICLE
Grace S Lee-Riddle, Harald J Schmidt, Peter P Reese, Maria N Nelson, Rebecca Neergaard, Frances K Barg, Marina Serper
Medication non-adherence is a leading cause of graft loss. Adherence monitoring technologies - reminder texts, smart bottles, video-observed ingestion, and digestion-activated signaling pills - may support adherence. However, patient, care partner, and clinician perceptions of these tools are not well studied. We conducted qualitative individual semi-structured interviews and focus groups among 97 participants at a single center: kidney and liver transplant recipients 2 weeks to 18 months post-transplant, their care partners, and transplant clinicians...
November 1, 2023: American Journal of Transplantation
#20
JOURNAL ARTICLE
Mary Moss Chandran, Elizabeth Cohen, Christina Teeter Doligalski, Lyndsey J Bowman, Tiffany E Kaiser, David J Taber
As healthcare continues its transition towards value-based care, it is increasingly important for transplant pharmacists to demonstrate their impact on patient care, health-related outcomes, and healthcare costs. Evidence-based quality and performance metrics are recognized as crucial tools for measuring the value of service. Yet, there is a lack of well-developed and agreed upon specific metrics for many clinical pharmacy specialties, including solid organ transplantation. To address this need, a panel of transplant pharmacy specialists conducted a detailed literature review and engaged in several panel discussions to identify quality metrics to be considered for assessing the value of clinical pharmacy services provided to solid organ transplant recipients and living donors...
November 1, 2023: American Journal of Transplantation
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