Journals American Journal of Transplant...

American Journal of Transplantation
Miho Akabane, Yuki Imaoka, Carlos O Esquivel, W Ray Kim, Kazunari Sasaki
Medical literature highlights differences in liver transplantation(LT) waitlist experiences among ABO blood types. Type AB candidates reportedly have higher LT rates and reduced mortality. Despite liver offer guidelines, ABO disparities persist. This study examines LT access discrepancies among blood types, focusing on type AB, and seeks equitable strategies. Using the UNOS database(2003-2022), 170,276 waitlist candidates were retrospectively analyzed. Dual predictive analyses(LT Opportunity&Survival Studies) evaluated 1-year recipient pool survival, considering waitlist and post-LT survival, alongside anticipated allocation value per recipient, under six scenarios...
June 10, 2024: American Journal of Transplantation
Amanda J Vinson, Makayla Schissel, Alfred J Anzalone, Ran Dai, Evan T French, Amy L Olex, Stephen B Lee, Michael Ison, Roslyn B Mannon
Post-acute sequelae after COVID-19 (PASC) is increasingly recognized, though data in solid organ transplant recipients (SOTR) are limited. Using the N3C, we performed 1:1 propensity score matching (PSM) of all adult SOTR and non-immunosuppressed/immunocompromised (ISC) patients with acute COVID (08-01-2021 to 01-13-2023), for a subsequent PASC diagnosis using ICD-10-CM codes. Multivariable logistic regression was used to examine the association of SOT status with PASC, but also other patient factors after stratifying by SOT status...
June 8, 2024: American Journal of Transplantation
Lorne Schweitzer, Pawel Muranski
Solid organ transplant recipients require ongoing immunosuppression to prevent acute rejection, which puts them at risk for opportunistic infections. Viral infections are particularly challenging to prevent and treat as many establish latency and thus cannot be eliminated, while targets for small molecule antiviral medications are limited. Resistance to antivirals and unacceptable toxicity also complicate treatment. Virus specific T cell therapies aim to restore host specific immunity to opportunistic viruses that is lacking due to ongoing immunosuppressive therapy...
June 8, 2024: American Journal of Transplantation
Mary Ott, Nicholas Murphy, Lorelei Lingard, Marat Slessarev, Laurie Blackstock, John Basmaji, Mayur Brahmania, Andrew Healey, Sam Shemie, Anton Skaro, Charles Weijer
Normothermic regional perfusion (NRP) is a promising technology to improve organ transplantation outcomes by reversing ischemic injury caused by controlled donation after circulatory determination of death. However, it has not yet been implemented in Canada due to ethical questions. These issues must be resolved to preserve public trust in organ donation and transplantation. This qualitative, constructivist grounded theory study sought to understand how those most impacted by NRP perceived the ethical implications...
May 31, 2024: American Journal of Transplantation
Muneyoshi Kimura, Matteo Rinaldi, Sagar Kothari, Maddalena Giannella, Shweta Anjan, Yoichiro Natori, Pakpoom Phoompoung, Emily Gault, Jonathan Hand, Matilde D'Asaro, Dionysios Neofytos, Nicolas J Mueller, Andreas E Kremer, Tereza Rojko, Marija Ribnikar, Fernanda P Silveira, Joshua Kohl, Angela Cano, Julian Torre-Cisneros, Rafael San-Juan, Jose Maria Aguado, Armaghan-E-Rehman Mansoor, Ige Abraham George, Alessandra Mularoni, Giovanna Russelli, Me-Linh Luong, Yamama A AlJishi, Maram N AlJishi, Bassem Hamandi, Nazia Selzner, Shahid Husain
Invasive aspergillosis (IA) is a rare but fatal disease among liver transplant recipients (LiTRs). We performed a multi-center 1:2 case-control study comparing LiTRs diagnosed with proven/probable IA and controls with no invasive fungal infection. We included 62 IA cases and 124 matched controls. Disseminated infection occurred only in eight cases (13%). 12-week all-cause mortality of IA was 37%. In multivariate analyses, systemic antibiotics usage (adjusted odds ratio [aOR], 4.74; p=0.03) and history of pneumonia (aOR, 48...
May 25, 2024: American Journal of Transplantation
Oren Shaked, Bao-Li Loza, Kim M Olthoff, K Rajender Reddy, Brendan J Keating, Giuliano Testa, Sumeet K Asrani, Abraham Shaked
Post-transplant diabetes mellitus (PTDM) is a prevalent complication of liver transplantation and is associated with cardiometabolic complications. We studied the consequences of genetic effects of liver donors and recipients on PTDM outcomes, focusing on the diverse genetic pathways related to insulin that play a role in the development of PTDM. 1115 liver transplant recipients without a pre-transplant diagnosis of type 2 diabetes mellitus (T2D) and their paired donors recruited from two transplant centers had polygenic risk scores (PRS) for T2D, insulin secretion, and insulin sensitivity calculated...
May 21, 2024: American Journal of Transplantation
Christopher Bobier, Daniel J Hurst, Daniel Rodger
No abstract text is available yet for this article.
May 21, 2024: American Journal of Transplantation
Sezai Yilmaz, Tayfun Sönmez, M Utku Ünver, Volkan Ince, Sami Akbulut, Kemal Baris Sarici, Burak Isik
A significant portion of liver transplantations in many countries is conducted via living-donor liver transplantation (LDLT). However, numerous potential donors are unable to donate to their intended recipients due to factors such as blood-type incompatibility or size incompatibility. Despite this, an incompatible donor for one recipient may still be a viable donor for another patient. In recent decades, several transplant centers have introduced liver paired exchange (LPE) programs, facilitating donor exchanges between patients and their incompatible donors, thereby enabling compatible transplants...
May 18, 2024: American Journal of Transplantation
Alyson Kaplan, Elizabeth S Aby, Sonia Scott, Christopher Sonnenday, Alyson Fox, Amit Mathur, Kim Olthoff, Julie Heimbach, Keren Ladin, Juliet Emamaullee
After two decades of limited growth, LDLT has been increasingly accepted as a promising solution to the growing organ shortage in the U.S. With experience, LDLT offers superior graft and patient survival with low rates of rejection. However, not all waitlisted patients have equal access to LDLT, with financial toxicity representing a substantial barrier. Potential living liver donors face indirect, direct, and opportunity costs associated with donation as well as insurance-based discrimination and variable employer leave policies...
May 17, 2024: American Journal of Transplantation
Im-Hong Sun, James M Gardner
No abstract text is available yet for this article.
May 16, 2024: American Journal of Transplantation
Maryam Valapour, Carli J Lehr, Andrew Wey, Melissa A Skeans, Jonathan Miller, Erika D Lease
No abstract text is available yet for this article.
May 11, 2024: American Journal of Transplantation
Abiu Sempere, Nerea Castillo, Francesc Rudilla, Sergi Querol, Emma Enrich, Cristina Prat-Vidal, Margarita Codinach, Frederic Cofan, Vicens Torregrossa, Fritz Dieckmann, Marta Bodro
The strategy for progressive multifocal leukoencephalopathy (PML) in solid organ transplant recipients primarily focuses on reducing immunosuppressive therapy. However, this approach offers limited efficacy and carries a high risk of graft loss. Here, we present the case of a 64-year-old male kidney transplant recipient with a high degree of immunosuppression who developed PML in October 2022. Despite the standard reduction of immunosuppressive therapy, the patient's condition continued to deteriorate, as evidenced by worsening neurological symptoms and increasing JC virus (JCV) DNA levels in cerebrospinal fluid...
May 9, 2024: American Journal of Transplantation
Zhongyang Zhang, Zeguo Sun, Peter Heeger, Madhav C Menon
No abstract text is available yet for this article.
May 9, 2024: American Journal of Transplantation
Amit K Mathur, Shimul A Shah
No abstract text is available yet for this article.
May 9, 2024: American Journal of Transplantation
Newsha Nikzad, Andrew R Fisher, Anjana Pillai, Laura E Targownik, Helen S Te, Andrew Aronsohn, Sonali Paul
Liver transplantation is lifesaving for patients with end-stage liver disease. Similar to the role of transplantation for patients with end-stage liver disease, gender-affirming hormone therapy (GAHT) can be lifesaving for transgender and gender diverse (TGGD) patients who experience gender dysphoria. However, management of such hormone therapy during the perioperative period is unknown and without clear guidelines. Profound strides can be made in improving care for TGGD patients through gender-affirming care and appropriate management of GAHT in liver transplantation...
May 8, 2024: American Journal of Transplantation
Dimitri A Raptis, Yasser Elsheikh, Yasir Alnemary, Kris Ann H Marquez, Khalid Bzeizi, Saad Alghamdi, Saleh Alabbad, Saleh A Alqahtani, Roberto I Troisi, Markus U Boehnert, Massimo Malago, Yao-Ming Wu, Dieter C Broering
UNLABELLED: Minimally invasive donor hepatectomy is an emerging surgical technique in living donor liver transplantation (LDLT). We examined outcomes across open, laparoscopic, and robotic LDLT using a prospective registry. We analyzed 3,448 cases (1,724 donor-recipient pairs) from Jan 2011 to Mar 2023 (NCT06062706). Among donors, 724 (42%) were female. Adult-to-adult LDLT comprised 1,061 (62%) cases. 646 (37%) of the donors underwent open, 165 (10%) laparoscopic, and 913 (53%) robotic hepatectomies...
May 7, 2024: American Journal of Transplantation
Maryna van Zyl, Elodie Cramer, Jan-Stephan Sanders, Henri Leuvenink, Ton Lisman, Mia-Jeanne van Rooy, Jan-Luuk Hillebrands
Kidney transplantation remains the gold standard for patients with end-stage renal disease, but severe donor organ shortage has led to long waiting lists. The utilization of expanded criteria donor kidneys within the category of deceased donors has enlarged the pool of available kidneys for transplantation, however, these grafts often have increased risk for delayed graft function or reduced graft survival following transplantation. During brain or circulatory death, neutrophils are recruited to the vascular beds of kidneys where a pro-inflammatory microenvironment might prime the formation of neutrophil extracellular traps (NETs), weblike structures, containing proteolytic enzymes, DNA and histones...
May 6, 2024: American Journal of Transplantation
Monica Fung, Ricardo M La Hoz, Christine M Durand, Dong Heun Lee, David Sears, Caitlin Hohe, Peter Chin-Hong, John P Roberts
No abstract text is available yet for this article.
May 3, 2024: American Journal of Transplantation
Han S Yin, Eva M Gillis-Buck, James M Gardner
No abstract text is available yet for this article.
May 1, 2024: American Journal of Transplantation
Cristina Martin-Martin, Beatriz Suarez-Alvarez, Monika González, Irina B Torres, Oriol Bestard, José E Martín, Gwendolyn Barceló-Coblijn, Francesc Moreso, Ana M Aransay, Carlos Lopez-Larrea, Ramon M Rodriguez
In this proof-of-concept study, spatial transcriptomics combined with public single-cell ribonucleic acid-sequencing data were used to explore the potential of this technology to study kidney allograft rejection. We aimed to map gene expression patterns within diverse pathologic states by examining biopsies classified across nonrejection, T cell-mediated acute rejection, interstitial fibrosis, and tubular atrophy. Our results revealed distinct immune cell signatures, including those of T and B lymphocytes, monocytes, mast cells, and plasma cells, and their spatial organization within the renal interstitium...
April 29, 2024: American Journal of Transplantation
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