Amos Muench, Daniel Teichmann, Dorothee Spille, Peter Kuzman, Eilis Perez, Sven-Axel May, Wolf C Mueller, Theodoros Kombos, Shokufe Nazari-Dehkordi, Julia Onken, Peter Vajkoczy, Georgios Ntoulias, Conceição Bettencourt, Andreas von Deimling, Werner Paulus, Frank L Heppner, Arend Koch, David Capper, David Kaul, Christian Thomas, Leonille Schweizer
Diffuse gliomas in adults encompass a heterogenous group of central nervous system neoplasms. In recent years, extensive (epi-)genomic profiling has identified several glioma subgroups characterized by distinct molecular characteristics, most importantly IDH1/2 and histone H3 mutations. A group of 16 diffuse gliomas classified as "adult-type diffuse high-grade glioma, IDH-wildtype, subtype F (HGG-F)" was identified by the DKFZ v12.5 Brain Tumor Classifier. Histopathologic characterization, exome sequencing, and review of clinical data was performed in all cases...
September 22, 2023: American Journal of Surgical Pathology