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American Journal of Surgical Pathology

Jie Xu, Lifu Wang, Jingyi Li, Annapurna Saksena, Sa A Wang, Jing Shen, Zhihong Hu, Pei Lin, Guilin Tang, C Cameron Yin, Michael Wang, L Jeffrey Medeiros, Shaoying Li
Studies have suggested that SOX11 expression has prognostic implications in patients with mantle cell lymphoma (MCL), but the data are controversial. In this study, we describe the clinicopathologic and prognostic features of 75 patients with SOX11-negative MCL. Compared with patients with SOX11-positive MCL, SOX11-negative MCL patients more frequently had leukemic non-nodal disease (21% vs. 4%, P=0.0001). SOX11-negative MCLs more often showed classic morphology (83% vs. 65%, P=0.005), were more often positive for CD23 (39% vs...
February 12, 2019: American Journal of Surgical Pathology
Joseph T Rabban, Emily Chan, Julie Mak, Charles Zaloudek, Karuna Garg
Pathology-based screening of uterine smooth muscle tumors (uSMT) for morphology suggestive of fumarate hydratase deficiency (FH-d morphology) has been proposed as a method to identify women at increased risk for hereditary leiomyomatosis renal cell carcinoma (HLRCC) syndrome. For 5 years our clinical diagnostic practice has evaluated all women with any type of uSMT for FH-d morphology (defined, at low magnification, as staghorn shaped blood vessels and alveolar pattern edema and, at high magnification, as tumor macronucleoli surrounded by a halo and cytoplasmic eosinophilic globules) and, when present, used the pathology report to advise genetic counseling to further evaluate for HLRCC syndrome...
February 6, 2019: American Journal of Surgical Pathology
(no author information available yet)
No abstract text is available yet for this article.
February 4, 2019: American Journal of Surgical Pathology
Christina A Arnold, Maryam K Pezhouh, Dora Lam-Himlin, Meredith E Pittman, Christopher VandenBussche, Lysandra Voltaggio
Selective internal radiation therapy with Y-TheraSphere or Y-SIRSphere is used in the treatment of unresectable hepatic malignancies. To the best of our knowledge, this is the first Y-TheraSpheres series. BTG International Canada Inc. provided nonradiated microspheres from the Nordion manufacturer. The histologic processed microspheres were colorless, refractile, polarizable, 20 to 30 μm in diameter, and an occasional internal bulls'-eye seen with the condenser out and an internal cross seen with polarized light...
February 1, 2019: American Journal of Surgical Pathology
Narasimhan P Agaram, Lei Zhang, Yun-Shao Sung, Marcela S Cavalcanti, Dianne Torrence, Leonard Wexler, Glenn Francis, Scott Sommerville, David Swanson, Brendan C Dickson, Albert J H Suurmeijer, Richard Williamson, Cristina R Antonescu
Primary intraosseous rhabdomyosarcomas (RMSs) are extremely rare. Recently 2 studies reported 4 cases of primary intraosseous RMS with EWSR1/FUS-TFCP2 gene fusions, associated with somewhat conflicting histologic features, ranging from spindle to epithelioid. In this study we sought to further investigate the pathologic and molecular abnormalities of a larger group of intraosseous RMSs by a combined approach using targeted RNA sequencing analysis and fluorescence in situ hybridization (FISH). We identified 7 cases, 3 males and 4 females, all in young adults, age range 20 to 39 years (median, 27 y)...
February 1, 2019: American Journal of Surgical Pathology
Simona Stolnicu, Lien Hoang, Derek Chiu, Orsolya Hanko-Bauer, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Esther Oliva, Kay J Park, Nadeem R Abu-Rustum, Robert A Soslow
The International Endocervical Adenocarcinoma Criteria and Classification (IECC) categorizes endocervical adenocarcinomas (ECAs) on the basis of morphologic features linked to etiology (ie, human papilloma virus [HPV] infection), resulting in separation of ECAs into HPV-associated (HPVA) and unassociated or non-HPVA (NHPVA) types. NHPVAs are reported to be large and present at high stage in older individuals. Our aim was to examine the clinical outcomes in these tumor types. Full slide sets of 205 ECAs were collected from 7 institutions worldwide and classified on the basis of IECC criteria and the presence or absence of HPV...
February 1, 2019: American Journal of Surgical Pathology
Martha Frances Wright, Justin Cates, Raul S Gonzales, Satya Das, Jordan D Berlin, Chanjuan Shi
The liver and peritoneum are the 2 most common distant metastatic sites for small intestinal neuroendocrine tumors (SI-NET). In this study, we evaluated the differential impact of hepatic and/or peritoneal metastasis on prognosis of SI-NET patients. Surgical Pathology archives were searched for SI-NET resections performed between January 1, 1994 and August 31, 2017. Two hundred nineteen cases with clinical follow-up data were identified. Pathology reports and electronic medical records were reviewed. The 219 patients included 104 females and 115 males with a median age of 59 years (range, 19 to 85 y)...
January 29, 2019: American Journal of Surgical Pathology
Christophe Bontoux, Barouyr Baroudjian, Christine Le Maignan, Laetitia Vercellino, Cécile Farges, Delphine Guillemot, Gaëlle Pierron, Céleste Lebbé, Maxime Battistella
No abstract text is available yet for this article.
January 22, 2019: American Journal of Surgical Pathology
Khaleel I Al-Obaidy, Muhammad T Idrees, David J Grignon, Thomas M Ulbright
Adenocarcinoma of the rete testis is rare and its etiological and pathologic characteristics are not well studied. We therefore investigated the clinical, morphologic, and immunohistochemical features of 6 cases diagnosed at our institution and conducted a detailed review of the literature. The mean age was 64 years. All patients presented with testicular masses; 4 were right-sided. On gross examination, all tumors were centered in the hilum and had solid and cystic cut surfaces. Microscopically, all had intrarete and invasive growth and showed multiple patterns, with a variable proportion of papillary, solid and glandular morphology, the latter varying from slit-like lumens to well-formed glands and tubules...
January 22, 2019: American Journal of Surgical Pathology
Diana Agostini-Vulaj, Burcin Pehlivanoglu, Sharon W Weiss, Alyssa Krasinskas, Michael M Feely, Jason L Hornick, Justin M M Cates, Karen L de Mesy Bentley, Nazmi Volkan Adsay, Raul S Gonzalez
Epithelioid hemangioendothelioma (EHE) is an angiocentric tumor that, when arising in liver, is centered around hepatic/portal veins. However, EHE cells can also track along sinusoids, which is not well recognized or studied. We identified 18 cases of hepatic EHE and 6 nonhepatic EHEs. For all cases, we recorded EHE multifocality and maximum size. When tumor cells were identified apart from the main mass, we recorded their location, maximum distance from the main tumor, density per high-power field, and cytomorphology...
January 16, 2019: American Journal of Surgical Pathology
Victor L Quan, Bin Zhang, Lauren S Mohan, Katherine Shi, Maria C Isales, Elnaz Panah, Timothy J Taxter, Nike Beaubier, Kevin White, Pedram Gerami
Recent studies have described kinase fusions as the most common initiating genomic events in Spitzoid neoplasms. Each rearrangement generates a chimeric protein with constitutive activation of the tyrosine kinase domain, resulting in the development of a Spitzoid neoplasm. Identifying key initiating genomic events and drivers may assist in diagnosis, prognostication, and management. Retrospective, consecutive search of our database between 2009 and 2018 for Spitzoid neoplasms identified 86 cases. Whole transcriptome mRNA and DNA sequencing (1714 genes) detected 9% of cases (8/86) with structural rearrangements in MAPK genes other than BRAF and 47% (40/86) with kinase fusions previously described in Spitzoid neoplasms...
January 11, 2019: American Journal of Surgical Pathology
Elodie Laurent, Hugues Begueret, Benjamin Bonhomme, Rémi Veillon, Matthieu Thumerel, Valérie Velasco, Véronique Brouste, Stéphanie Hoppe, Marion Fournier, Thomas Grellety, Gaëtan MacGrogan
Triple-negative breast cancer (TNBC) patients have an increased risk of developing visceral metastases and other primary nonbreast cancers, particularly lung cancer. The differential diagnosis of TNBC metastases and primary cancers from other organs can be difficult due to lack of a TNBC standard immunoprofile. We analyzed the diagnostic value of estrogen receptor, progesterone receptor, human epidermal growth factor receptor, thyroid transcription factor-1 (TTF1), Napsin A, mammaglobin, gross cystic disease fluid protein 15 (GCDFP15), Sry-related HMg-Box gene 10 (SOX10), GATA-binding protein 3 (GATA3), and androgen receptor in a series of 207 TNBC and 152 primary lung adenocarcinomas (LA)...
January 8, 2019: American Journal of Surgical Pathology
Justin M M Cates
The College of American Pathologists recommends reporting the histologic response of soft tissue sarcomas (STS) to neoadjuvant therapy, presumably as an assessment of chemosensitivity and a prognostic indicator, despite lack of evidence of clinical utility as such. This study examines whether extent of neoadjuvant therapy effect in STS is a favorable prognostic factor for disease-free survival. Extent of tumor necrosis and stromal hyalinization/fibrosis were determined in 143 high-grade, nonmetastatic, pleomorphic STS of the extremity or trunk...
January 8, 2019: American Journal of Surgical Pathology
Yuhua Huang, Xiaolan Shi, Peng Zhong, Yu Wang, Hualiang Xiao, Xiaoge Zhou, Jingping Yun
Although the testis is not uncommonly involved during the course of disease in both nasal and non-nasal extranodal NK/T-cell lymphoma (ENKTCL), only a few cases presenting initially with a testicular mass have been previously reported. These have been documented as case reports, rather than as study series. Because of its rarity, the clinicopathologic features and the prognosis of de novo testicular ENKTCL have not been well characterized. Clinicopathologic features of 21 cases of de novo testicular ENKTCL from 3 institutions in China were retrospectively analyzed with review of an additional 18 cases from the literature...
December 26, 2018: American Journal of Surgical Pathology
Nick Baniak, Oluwole Fadare, Martin Köbel, John DeCoteau, Vinita Parkash, Jonathan L Hecht, Krisztina Z Hanley, Katja Gwin, Wenxin Zheng, Charles M Quick, Elke A Jarboe, Sharon X Liang, Mary Kinloch
Endometrial clear cell carcinoma (ECCC) is an uncommon histotype without unique identified molecular alterations. Recently, The Cancer Genome Atlas molecular subtypes have been reported in ECCC. ECCC cases were collected from 11 institutions with diagnoses confirmed by morphologic review and immunohistochemistry. DNA mismatch repair (MMR) proteins, p53 expression, and ARID1A expression was assessed by immunohistochemistry on tissue microarrays. Targeted next-generation sequencing was completed for POLE, TP53, KRAS, and PIK3CA...
December 24, 2018: American Journal of Surgical Pathology
Li-Li Tao, Yu-Hua Huang, Yao-Li Chen, Guang-Yin Yu, Wei-Hua Yin
SSTR2a, a member of the somatostatin receptor family, has been used as a diagnostic marker of meningioma. However, the expression of SSTR2a in follicular dendritic cells (FDCs) and their related tumors has been poorly characterized. This study aimed to assess the potential diagnostic utility of measuring SSTR2a immunohistochemically in FDCs and their related tumors. We evaluated whole-tissue sections from 182 cases including 83 lymphoid reactive follicular hyperplasias, 17 follicular lymphomas, 18 follicular dendritic cell sarcomas (FDCSs), 6 inflammatory pseudotumor-like FDCSs, and 58 other histologic mimics...
December 24, 2018: American Journal of Surgical Pathology
Jessica L Davis, Christina M Lockwood, Bradley Stohr, Carolin Boecking, Alyaa Al-Ibraheemi, Steven G DuBois, Sara O Vargas, Jennifer O Black, Michael C Cox, Mark Luquette, Brian Turpin, Sara Szabo, Theodore W Laetsch, Catherine M Albert, David M Parham, Douglas S Hawkins, Erin R Rudzinski
Pediatric mesenchymal tumors harboring variant NTRK fusions (ETV6-negative) are being increasingly described; however, the histologic and clinical features of these variant NTRK tumors and their relationship to classic infantile fibrosarcoma are not well characterized. A better understanding of the clinicopathologic features of these tumors is necessary, and would aid in both early diagnosis and treatment. Therefore, the aim of this study was to characterize a series of pediatric NTRK-rearranged mesenchymal tumors, including classic ETV6-NTRK3 fused tumors and tumors with variant (non-ETV6) NTRK fusions...
December 24, 2018: American Journal of Surgical Pathology
Florian Puls, Nischalan Pillay, Henrik Fagman, Anne Palin-Masreliez, Fernanda Amary, Magnus Hansson, Lars-Gunnar Kindblom, Tom A McCulloch, George Meligonis, Ronald Muc, Pehr Rissler, Vaiyapuri P Sumathi, Roberto Tirabosco, Jakob Hofvander, Linda Magnusson, Jenny Nilsson, Adrienne M Flanagan, Fredrik Mertens
Gene fusion transcripts containing PRDM10 were recently identified in low-grade undifferentiated pleomorphic sarcomas (UPS). Here, we describe the morphologic and clinical features of 9 such tumors from 5 men and 4 women (age: 20 to 61 y). Three cases had previously been diagnosed as UPS, 3 as superficial CD34-positive fibroblastic tumor (SCD34FT), 2 as pleomorphic liposarcoma, and 1 as pleomorphic hyalinizing angiectatic tumor. The tumors were located in the superficial and deep soft tissues of the thigh/knee region (4 cases), shoulder (2 cases), foot, trunk, and perineum (1 case each) ranging in size from 1 to 6 cm...
December 18, 2018: American Journal of Surgical Pathology
Viacheslav Iremashvili, Liset Pelaez, Merce Jorda, Dipen J Parekh, Sanoj Punnen
Our objective was to identify the best of the existing definitions of Gleason score (GS) at a positive surgical margin (PSM) by validating them in our radical prostatectomy cohort. We analyzed 251 patients who had mixed (3+4, 3+5, 4+3 or 5+3) pathologic GS and PSM. We used 5 definitions to record GS at a PSM. Univariate and multivariate analyses were used to study the association between each definition and the risk of biochemical recurrence (BCR). We also tested the prognostic value of multivariate models including established predictors and each of the studied definitions of GS at a PSM...
December 14, 2018: American Journal of Surgical Pathology
Vincent Cracolici, Sabah Kadri, Lauren L Ritterhouse, Jeremy P Segal, Pankhuri Wanjari, Nicole A Cipriani
Metastatic follicular thyroid carcinoma (FTC) is rare. The aim of this study was to determine the clinical, histologic, and molecular differences between patients with metastatic FTC who present with distant metastatic (DM) disease versus those who present with a primary thyroid nodule (PT). Clinical and pathologic information was extracted from the medical record and surgical pathology report. When available, slides were reviewed. Molecular testing was performed on available primary and/or metastatic lesions...
December 14, 2018: American Journal of Surgical Pathology
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