Journals American Journal of Surgical P...

American Journal of Surgical Pathology
Amy S Joehlin-Price, Miglena K Komforti, Nicholas R Ladwig, Patrick Devine, Carrie Hoyle, Lauren McCoy, Cathy Sprague, Caroline Astbury, Raza Hoda, Yunn-Yi Chen, Karuna Garg
Among gynecologic cancers, uterine serous carcinoma (USC) has been shown to be human epidermal growth factor receptor 2 (HER2) amplified and trastuzumab has been included in the recent National Comprehensive Cancer Network (NCCN) guidelines for treatment of advanced stage or recurrent USC with HER2 overexpression/amplification. There is limited literature suggesting that a subset of high-grade endometrioid carcinomas with aberrant p53 expression may also be HER2 amplified and these patients could benefit from the addition of targeted therapy...
March 20, 2023: American Journal of Surgical Pathology
Mitzi Aguilar, Hao Chen, Subhransu S Sahoo, Wenxin Zheng, Jessica Grubman, Jeffrey A SoRelle, Elena Lucas, Diego H Castrillon
Despite refinements in histologic criteria for the diagnosis of endometrioid precancers, many challenging cases are encountered in daily practice, creating diagnostic uncertainty and suboptimal patient management. Recently, an immunohistochemical 3-marker panel consisting of β-catenin, Pax2, and Pten was identified as a useful diagnostic adjunct. However, previous studies focused either on cancers or diagnostically unambiguous precancers, leaving questions about the applicability and utility of the panel in endometria with architectural features near or below the threshold of accepted histologic criteria for endometrioid precancers...
March 20, 2023: American Journal of Surgical Pathology
Ifeyinwa E Obiorah, Nadine S Aguilera, Alejandro Gru, Elizabeth L Courville
Ultrasensitive bright-field RNA in situ hybridization (BRISH) can be used to detect lower levels of light chain expression than immunohistochemical stains or conventional colorimetric RNA in situ hybridization. In this study, we retrospectively reviewed 77 lymph node specimens with follicular hyperplasia and kappa/lambda BRISH performed as part of the diagnostic evaluation. Thirty-two of the specimens had ≥1 germinal center(s) (GC) showing light chain restriction (14 specimens with lambda-restricted GC, 9 with kappa-restricted GC, and 9 with separate kappa-restricted or lambda-restricted GC)...
March 20, 2023: American Journal of Surgical Pathology
Costantino Ricci, Maria V Altavilla, Barbara Corti, Ernesto Pasquini, Livo Presutti, Anna M Baietti, Luca Amorosa, Tiziana Balbi, Chiara Baldovini, Francesca Ambrosi, Marco Grillini, Antonia D'Errico, Michelangelo Fiorentino, Maria P Foschini
PRAME (PReferentially expressed Antigen in MElanoma), a cancer-testis antigen expressed in normal and neoplastic tissues with several functions, proved to be a useful diagnostic tool in the differential diagnosis between benign and malignant melanocytic lesions. The current study aims to perform PRAME stain on a retrospective case series of mucosal melanocytic tumors of the head and neck region to compare 3 different scores and evaluate the most reliable one in this diagnostic set. Immunohistochemical analysis for PRAME was performed in 54 benign and malignant mucosal melanocytic tumors of the head and neck region collected from 41 patients...
March 13, 2023: American Journal of Surgical Pathology
Francoise Galateau-Salle, Trevor Hamilton, Andrea MacNeill, Véronique Hofman, Ruth Sequeiros, Christine Sagan, Nolwenn Le Stang, Andrew Churg
We have previously hypothesized that well-differentiated papillary mesothelial tumor (WDPMT) consists of 2 morphologically identical lesions, one of which is true WDPMT, while the other is a form of mesothelioma in situ. Here, we report 8 examples of the latter phenomenon, 3 with pleural disease (2 men/1 woman, ages 66 to 78 y); and 5 with peritoneal disease (all women, ages 31 to 81 y). At presentation the pleural cases all had effusions but no evidence of pleural tumor on imaging. Four of the 5 peritoneal cases had ascites as the initial finding and all 4 had nodular lesions that by imaging and/or direct inspection were thought to represent a diffuse peritoneal malignancy...
March 6, 2023: American Journal of Surgical Pathology
Kotaro Uemura, Masato Komatsu, Shigeo Hara, Teruya Kawamoto, Yuko Bitoh, Tomoo Itoh, Takanori Hirose
Angiofibroma of soft tissue (AFST) is a recently described benign fibroblastic neoplasm composed of uniform bland spindle cell proliferation in fibrous and fibromyxoid stroma with prominent thin-walled small branching vessels. A major recurrent genetic abnormality in AFST is t(5;8)(p15;q13), which results in the rearrangement of AHRR and NCOA2. Owing to a lack of discriminatory IHC markers and potential overlap with other mesenchymal neoplasms, it may be difficult to confirm the diagnosis of AFST in some cases...
March 6, 2023: American Journal of Surgical Pathology
Rachelle P Mendoza, Peng Wang, Jefree J Schulte, Melissa Y Tjota, Ina Jani, Anna C Martinez, Rishikesh Haridas, Pankhuri Wanjari, George Steinhardt, Noah Brown, Bryan L Betz, David B Chapel, Elizabeth Kertowidjojo, S D Yamada, Jennifer A Bennett
Subclonal loss of mismatch repair (MMR) proteins has been described in a small subset of endometrial carcinomas (ECs), but the genomic basis for this phenomenon has received limited attention. Herein, we retrospectively evaluated all ECs with MMR immunohistochemistry (n=285) for subclonal loss, and in those (n=6), performed a detailed clinicopathologic and genomic comparison of the MMR-deficient and MMR-proficient components. Three tumors were FIGO stage IA, and one each stage IB, II, and IIIC2. Patterns of subclonal loss were as follows: (1) 3 FIGO grade 1 endometrioid carcinomas with subclonal MLH1/PMS2, MLH1 promoter hypermethylation, and no MMR gene mutations; (2) POLE-mutated FIGO grade 3 endometrioid carcinoma with subclonal PMS2, and PMS2 and MSH6 mutations limited to the MMR-deficient component; (3) dedifferentiated carcinoma with subclonal MSH2/MSH6, as well as complete loss of MLH1/PMS2, MLH1 promoter hypermethylation, and PMS2 and MSH6 mutations in both components; (4) dedifferentiated carcinoma with subclonal MSH6, and somatic and germline MSH6 mutations in both components, but with a higher allele frequency in MMR-deficient foci...
March 3, 2023: American Journal of Surgical Pathology
William J Anderson, Fei Dong, Christopher D M Fletcher, Michelle S Hirsch, Marisa R Nucci
Perivascular epithelioid cell tumors (PEComas) are a distinctive group of mesenchymal neoplasms that demonstrate features of smooth muscle and melanocytic differentiation. Here, we present the clinicopathologic, immunohistochemical, and molecular features of 15 uterine sarcomas diagnosed as malignant PEComa. The median patient age was 56 years (range: 27 to 86 y). The median tumor size was 8.0 cm (range: 5.0 to 14.0 cm). All tumors were classified as malignant based on the presence of mitoses (15/15; 100%), necrosis (15/15; 100%), lymphovascular invasion (8/15; 53%), and high nuclear grade (13/15; 87%)...
March 1, 2023: American Journal of Surgical Pathology
Rebekka Wiedenhoefer, Elisa Schmoeckel, Marcel Grube, Mihály Sulyok, Iana Pasternak, Christine Beschorner, Karen Greif, Sara Brucker, Doris Mayr, Stefan Kommoss, Falko Fend, Annette Staebler, Anna K Fischer
Mucinous ovarian carcinoma (MOC) is a rare histotype of primary ovarian carcinoma. Frequent pathogenic molecular alterations include mutations in KRAS, TP53, and overexpression of human epidermal growth factor receptor 2, but without having prognostic relevance. As L1-CAM (cell adhesion molecule) has previously shown prognostic relevance in other epithelial tumors of the female genital tract, we analyzed whether L1-CAM expression affected MOC prognosis. In addition, we investigated L1-CAM expression in mucinous borderline tumors (MBOTs) with and without adjacent MOC to identify its potential role in the pathogenesis of MOC...
February 28, 2023: American Journal of Surgical Pathology
Utako Ishimoto-Namiki, Yoshinori Ino, Minoru Esaki, Kazuaki Shimada, Masayuki Saruta, Nobuyoshi Hiraoka
Acinar cell carcinoma (ACC) is a rare and highly malignant pancreatic tumor. Owing to histologic similarity, ACC is often difficult to distinguish from other solid medullary pancreatic tumors, particularly neuroendocrine neoplasm (NEN) and intraductal tubulopapillary neoplasm (ITPN). We aimed to identify new immunohistochemical markers commonly expressed in tumor cells with acinar cell differentiation and useful for both surgical and small biopsy specimens. Candidate molecules exclusively expressed in neoplastic or non-neoplastic acinar cells in pancreatic tissues with specific and available antibodies suitable for immunohistochemistry were selected...
February 23, 2023: American Journal of Surgical Pathology
Nya D Nelson, Feng Xu, William H Peranteau, Marilyn Li, Jennifer Pogoriler
Congenital pulmonary airway malformations (CPAMs) have a range of morphologies with varying cyst sizes and histologic features (types 1 to 3). Evidence suggested they arise secondary to bronchial atresia, however, we recently showed that cases with type 1 and 3 morphology are driven by mosaic KRAS mutations. We hypothesized that 2 distinct mechanisms account for most CPAMs: one subset is secondary to KRAS mosaicism and another is due to bronchial atresia. Cases with type 2 histology, similar to sequestrations, would be related to obstruction and therefore negative for KRAS mutations regardless of cyst size...
February 21, 2023: American Journal of Surgical Pathology
Dimas Suárez-Vilela, Francisco M Izquierdo, Emiliano Honrado, Cristina Díez-Tascón
No abstract text is available yet for this article.
February 16, 2023: American Journal of Surgical Pathology
Andres M Acosta, Julia A Bridge, Paola S Dal Cin, Lynette M Sholl, Kristine M Cornejo, Christopher D M Fletcher, Thomas M Ulbright
A subset of malignant testicular sex cord tumors (TSCTs), heretofore interpreted as Sertoli cell tumors, not otherwise specified, exhibits distinctive morphologic features that partially overlap with those of seminoma. In this study, we evaluated the clinicopathologic and molecular characteristics of 13 such tumors. The patients were 20 to 73 years old (median, 36 y), and all with available data presented with testicular masses (median size, 3 cm), with 2 having synchronous retroperitoneal metastases...
February 15, 2023: American Journal of Surgical Pathology
Anne Graber, Jacqueline Koike, Gieri Cathomas
No abstract text is available yet for this article.
February 15, 2023: American Journal of Surgical Pathology
Aaron J Sohn, Mehran Taherian, Matthew H G Katz, Laura R Prakash, Deyali Chatterjee, Hua Wang, Michael Kim, Ching-Wei D Tzeng, Jeffrey E Lee, Naruhiko Ikoma, Asif Rashid, Robert A Wolff, Dan Zhao, Eugene J Koay, Ryan Sun, Anirban Maitra, Huamin Wang
Neoadjuvant therapy is increasingly used to treat patients with pancreatic ductal adenocarcinoma (PDAC). Pathologic parameters of treated PDAC, including tumor (ypT) and lymph node (ypN) stage, and tumor response grading (TRG) are important prognostic factors in this group of patients. To our knowledge, a multifactorial prognostic score combining pathologic features including ypT, ypN, and TRG in treated PDAC patients has not been reported. Our cohort consisted of 398 PDAC patients who received neoadjuvant therapy and underwent pancreaticoduodenectomy at our institution...
February 6, 2023: American Journal of Surgical Pathology
Kiril Trpkov
No abstract text is available yet for this article.
January 23, 2023: American Journal of Surgical Pathology
Paige H Parrack, Adrian Mariño-Enríquez, Christopher D M Fletcher, Jason L Hornick, David J Papke
Glioma-associated oncogene 1 (GLI1) alterations have been described in pericytoma with t(7;12), gastroblastoma, plexiform fibromyxoma, and an emerging class of GLI1-rearranged or amplified mesenchymal neoplasms including "nested glomoid neoplasm". The immunophenotype of these tumor types is nonspecific, making some cases difficult to diagnose without sequencing. The utility of GLI1 immunohistochemistry (IHC) in distinguishing nested glomoid neoplasms and pericytomas with t(7;12) from morphologic mimics is unknown...
January 23, 2023: American Journal of Surgical Pathology
Qiu-Yuan Xia, Xiao-Tong Wang, Ming Zhao, Qiu Rao
No abstract text is available yet for this article.
January 19, 2023: American Journal of Surgical Pathology
Claudio Luchini, Paola Mattiolo, Olca Basturk, Andrea Mafficini, Kerem Ozcan, Rita T Lawlor, Seung-Mo Hong, Lodewijk A Brosens, Giovanni Marchegiani, Antonio Pea, Erminia Manfrin, Giuseppe Sciacca, Federica Zampieri, Rita Polati, Riccardo De Robertis, Michele Milella, Mirko D'Onofrio, Giuseppe Malleo, Roberto Salvia, Volkan Adsay, Aldo Scarpa
Acinar cystic transformation (ACT) of the pancreas, previously called acinar cell cystadenoma, is a poorly understood and rare entity among pancreatic cystic lesions. This study aims to clarify its real nature. This research cohort included 25 patients with pancreatic ACT, representing the largest series in the literature. We describe their clinicopathological features and molecular profile using next-generation sequencing. ACT arose more often in women (F/M≃2:1), in the body-tail region, with a mean size of ~4 cm...
January 16, 2023: American Journal of Surgical Pathology
Syed A Hoda, Raza S Hoda
No abstract text is available yet for this article.
January 10, 2023: American Journal of Surgical Pathology
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