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Journals
American Journal of Respirator...
American Journal of Respiratory and Critical Care Medicine
#21
JOURNAL ARTICLE
David M Mannino
No abstract text is available yet for this article.
May 11, 2023: American Journal of Respiratory and Critical Care Medicine
#22
JOURNAL ARTICLE
Sipeng Shen, Zaiming Li, Yunke Jiang, Weiwei Duan, Hongru Li, Sha Du, Manel Esteller, Hongbing Shen, Zhibin Hu, Yang Zhao, David C Christiani, Feng Chen
RATIONALE: Genome-wide association studies (GWAS) have identified common variants of lung cancer. However, the contribution of rare exome-wide variants, especially protein-coding variants, to cancers remains largely unexplored. OBJECTIVES: To evaluate the role of human exomes in genetic predisposition to lung cancer. MEASUREMENTS AND METHODS: We performed exome-wide association studies (ExWAS) to detect the association of exomes with lung cancer in 30,312 patients and 652,902 controls...
May 11, 2023: American Journal of Respiratory and Critical Care Medicine
#23
JOURNAL ARTICLE
Bartolome Celli
No abstract text is available yet for this article.
May 11, 2023: American Journal of Respiratory and Critical Care Medicine
#24
JOURNAL ARTICLE
Mahmoud I Abdel-Aziz, Jonathan Thorsen, Simone Hashimoto, Susanne J H Vijverberg, Anne H Neerincx, Paul Brinkman, Wim van Aalderen, Jakob Stokholm, Morten Arendt Rasmussen, Michael Roggenbuck-Wedemeyer, Nadja H Vissing, Martin Steen Mortensen, Asker Daniel Brejnrod, Louise J Fleming, Clare S Murray, Stephen J Fowler, Urs Frey, Andrew Bush, Florian Singer, Gunilla Hedlin, Björn Nordlund, Dominick E Shaw, Kian Fan Chung, Ian M Adcock, Ratko Djukanovic, Charles Auffray, Aruna T Bansal, Ana R Sousa, Scott S Wagers, Bo Lund Chawes, Klaus Bønnelykke, Søren Johannes Sørensen, Aletta D Kraneveld, Peter J Sterk, Graham Roberts, Hans Bisgaard, Anke H Maitland-van der Zee
RATIONALE: Children with preschool wheezing or school-age asthma are reported to have airway microbial imbalances. OBJECTIVE: To identify clusters in children with asthma or wheezing using oropharyngeal microbiota profiles. METHODS: Oropharyngeal swabs, from the Unbiased BIOmarkers for the Prediction of REspiratory Disease outcomes pediatric asthma/wheezing cohort, were characterized by 16S rRNA gene sequencing and unsupervised hierarchical clustering was performed on the Bray-Curtis β-diversity...
May 10, 2023: American Journal of Respiratory and Critical Care Medicine
#25
JOURNAL ARTICLE
Robert Banzett, Dimitrios Georgopoulos
No abstract text is available yet for this article.
May 9, 2023: American Journal of Respiratory and Critical Care Medicine
#26
JOURNAL ARTICLE
Marcos Valiente Fernández
No abstract text is available yet for this article.
May 9, 2023: American Journal of Respiratory and Critical Care Medicine
#27
JOURNAL ARTICLE
Jose Dianti, Idunn S Morris, Ewan C Goligher
No abstract text is available yet for this article.
May 9, 2023: American Journal of Respiratory and Critical Care Medicine
#28
JOURNAL ARTICLE
Brian H Cuthbertson
No abstract text is available yet for this article.
May 9, 2023: American Journal of Respiratory and Critical Care Medicine
#29
JOURNAL ARTICLE
Steven D Nathan
Pulmonary hypertension frequently complicating the course of patients with fibrotic interstitial lung disease is associated with significantly increased morbidity and mortality. The availability of multiple medications to treat pulmonary arterial hypertension has resulted in these agents being used beyond their original indication, including in patients with interstitial lung disease. Whether pulmonary hypertension in the context of interstitial lung disease is an adaptive response not to be treated, or a maladaptive phenomenon amenable to therapy, has been uncertain...
May 9, 2023: American Journal of Respiratory and Critical Care Medicine
#30
JOURNAL ARTICLE
Kevin W Southern, Jürg Barben, Stephen Goldring, Rachel Kneen, Suzanne Southward, Yashavi Rajeev, Jane C Davies, Andrew Bush
No abstract text is available yet for this article.
May 9, 2023: American Journal of Respiratory and Critical Care Medicine
#31
JOURNAL ARTICLE
Wassim W Labaki, Tian Gu, Susan Murray, Jeffrey L Curtis, J Michael Wells, Surya P Bhatt, Jessica Bon, Alejandro A Diaz, Craig P Hersh, Emily S Wan, Victor Kim, Terri H Beaty, John E Hokanson, Russell P Bowler, Douglas A Arenberg, Ella A Kazerooni, Fernando J Martinez, Edwin K Silverman, James D Crapo, Barry J Make, Elizabeth A Regan, MeiLan K Han
RATIONALE: Cigarette smoking contributes to risk of death through different mechanisms. OBJECTIVES: To determine how causes of and clinical features associated with death vary in tobacco cigarette users by lung function impairment. METHODS: We stratified current and former tobacco cigarette users enrolled in COPDGene into normal spirometry, Preserved Ratio Impaired Spirometry (PRISm), GOLD 1-2 and GOLD 3-4 COPD. Deaths were identified via longitudinal follow-up and Social Security Death Index search...
May 9, 2023: American Journal of Respiratory and Critical Care Medicine
#32
JOURNAL ARTICLE
Claire Wainwright, Susanna A McColley, Paul McNally, Michael Powers, Felix Ratjen, Jonathan H Rayment, George Retsch-Bogart, Erica Roesch, Neil Ahluwalia, Anna Chin, Chenghao Chu, Mengdi Lu, Prema Menon, David Waltz, Tanya Weinstock, Laura Zelazoski, Jane C Davies
RATIONALE: A 24-week, phase 3, open-label study showed elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was safe and efficacious in children aged 6 through 11 years with cystic fibrosis and ≥1 F508del-CFTR allele. OBJECTIVES: To assess long-term safety and efficacy of ELX/TEZ/IVA in children who completed the pivotal 24-week phase 3 trial. METHODS: In this phase 3, two-part (Part A and Part B), open-label extension study, children aged ≥6 years with cystic fibrosis heterozygous for F508del and a minimal function CFTR mutation (F/MF genotypes) or homozygous for F508del (F/F genotype) who completed the 24-week parent study received ELX/TEZ/IVA based on weight...
May 8, 2023: American Journal of Respiratory and Critical Care Medicine
#33
JOURNAL ARTICLE
Ellen A Gorman, Jennifer Rynne, Hannah J Gardiner, Anthony J Rostron, Jonathan Bannard-Smith, Andrew M Bentley, David Brealey, Christina Campbell, Gerard Curley, Mike Clarke, Ahilanadan Dushianthan, Phillip Hopkins, Colette Jackson, Kallirroi Kefela, Anna Krasnodembskaya, John G Laffey, Cliona McDowell, Margaret McFarland, Jamie McFerran, Peter McGuigan, Gavin D Perkins, Jonathan Silversides, Jon Smythe, Jacqui Thompson, William S Tunnicliffe, Ingeborg Dm Welters, Laura Amado-Rodríguez, Guillermo Albaiceta, Barry Williams, Manu Shankar-Hari, Daniel F McAuley, Cecilia M O'Kane
RATIONALE: Mesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair in COVID-19-related Acute Respiratory Distress Syndrome (ARDS). OBJECTIVES: We investigated safety and efficacy of ORBCEL-C (CD362-enriched, umbilical cord-derived MSCs) in COVID-related ARDS. METHODS: This multicentre, randomised, double-blind, allocation concealed, placebo-controlled trial (NCT03042143) randomised patients with moderate-to-severe COVID-related ARDS to receive ORBCEL-C (400million cells) or placebo (Plasma-Lyte148)...
May 8, 2023: American Journal of Respiratory and Critical Care Medicine
#34
JOURNAL ARTICLE
Tommaso Mauri, Elena Spinelli, Quazi Ibrahim, Bram Rochwerg, Roberto Lorusso, Joseph E Tonna, Susanna Price, Graeme MacLaren, Antonio Pesenti, Arthur S Slutsky, Daniel Brodie
No abstract text is available yet for this article.
May 4, 2023: American Journal of Respiratory and Critical Care Medicine
#35
JOURNAL ARTICLE
Jean-François Augusto, Céline Beauvillain, Caroline Poli, Léa Paolini, Isabelle Tournier, Pascale Pignon, Simon Blanchard, Laurence Preisser, Raffaella Soleti, Chloé Delépine, Marine Monnier, Isabelle Douchet, Pierre Asfar, François Beloncle, Olivier Guisset, Renaud Prével, Alain Mercat, Emeline Vinatier, Julien Goret, Jean-François Subra, Dominique Couez, Mark R Wilson, Patrick Blanco, Pascale Jeannin, Yves Delneste
RATIONALE: Extracellular histones, released into the surrounding environment during extensive cell death, promote inflammation and cell death and these deleterious roles have been well documented in sepsis. Clusterin (CLU) is a ubiquitous extracellular protein that chaperones misfolded proteins and promotes their removal. OBJECTIVES: We investigated whether CLU could protect against the deleterious properties of histones. METHODS: We assessed CLU and histones expression in sepsis patients and evaluated the protective role of CLU against histones in in vitro assays and in vivo models of experimental sepsis...
May 4, 2023: American Journal of Respiratory and Critical Care Medicine
#36
JOURNAL ARTICLE
Craig L Phillips, Nathaniel S Marshall
No abstract text is available yet for this article.
May 4, 2023: American Journal of Respiratory and Critical Care Medicine
#37
JOURNAL ARTICLE
Quentin De Roux, Adrien Coëffic, Alexia Letord, Agathe Kudela, Nicolas Mongardon
No abstract text is available yet for this article.
May 4, 2023: American Journal of Respiratory and Critical Care Medicine
#38
JOURNAL ARTICLE
Ganesh Raghu, Luca Richeldi, Carey C Thomson, Martine Remy-Jardin, Kevin C Wilson
No abstract text is available yet for this article.
May 2, 2023: American Journal of Respiratory and Critical Care Medicine
#39
JOURNAL ARTICLE
Kai E Swenson, Emily A DuComb, David Abia-Trujillo, Adnan Majid, Mihir S Parikh
No abstract text is available yet for this article.
May 2, 2023: American Journal of Respiratory and Critical Care Medicine
#40
JOURNAL ARTICLE
Kenki Matsumoto, Nicola Read, Keir E J Philip, James P Allinson
No abstract text is available yet for this article.
April 27, 2023: American Journal of Respiratory and Critical Care Medicine
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