journal
https://read.qxmd.com/read/38245252/chronic-sleep-deprivation-impairs-visual-functions-via-oxidative-damage-in-mice
#41
JOURNAL ARTICLE
Liying Tang, Houjian Zhang, Yi Liao, Shengmei Zhou, Yaqiong Yang, Mouxin Zhang, Yuli Guo, Tingyu Xie, Shikun Chen, Weijie Ouyang, Xiang Lin, Shaopan Wang, Caihong Huang, Minjie Zhang, Jingbin Zhuang, Jiankai Zhao, Rongrong Zhang, Changjun Zhang, Zibing Jin, Jiaoyue Hu, Zuguo Liu
Sleep deprivation (SD) is a global public health burden, and has a detrimental role in the nervous system. Retina is an important part of the central nervous system; however, whether SD affects retinal structures and functions remains largely unknown. Herein, chronic SD mouse model indicated that loss of sleep for 4 months could result in reductions in the visual functions, but without obvious morphologic changes of the retina. Ultrastructural analysis by transmission electron microscope revealed the deterioration of mitochondria, which was accompanied with the decrease of multiple mitochondrial proteins in the retina...
February 2024: American Journal of Pathology
https://read.qxmd.com/read/38245251/macrophage-activation-in-synovitis-and-osteoarthritis-of-temporomandibular-joint-and-its-relationship-with-the-progression-of-synovitis-and-bone%C3%A2-remodeling
#42
JOURNAL ARTICLE
Shiyu Hu, Huimin Li, Henghua Jiang, Xin Liu, Jin Ke, Xing Long
This study investigates the regulatory mechanisms of synovial macrophages and their polarization in the progression of temporomandibular joint osteoarthritis (TMJOA). Macrophage depletion models were established by intra-articular injection of clodronate liposomes and unloaded liposomes. TMJOA was induced by intra-articular injection of 50 μL Complete Freund's Adjuvant and the surgery of disc perforation. The contralateral joint was used as the control group. The expression of F4/80, CD86, and CD206 in the synovium was detected by immunofluorescence staining analysis...
February 2024: American Journal of Pathology
https://read.qxmd.com/read/37923250/alternative-splicing-factor-heterogeneous-nuclear-ribonucleoprotein-u-as-a-promising-biomarker-for-gastric-cancer-risk-and-prognosis-with-tumor-promoting-properties
#43
JOURNAL ARTICLE
Ying-Ying Dong, Meng-Ya Wang, Jing-Jing Jing, Yi-Jun Wu, Hao Li, Yuan Yuan, Li-Ping Sun
Gastric cancer (GC) is a major global health concern with poor outcomes. Heterogeneous nuclear ribonucleoprotein U (HNRNPU) is a multifunctional protein that participates in pre-mRNA packaging, alternative splicing regulation, and chromatin remodeling. Its potential role in GC remains unclear. In this study, the expression characteristics of HNRNPU were analyzed by The Cancer Genome Atlas data, Gene Expression Omnibus data, and then further identified by real-time quantitative PCR and immunohistochemistry using tissue specimens...
January 2024: American Journal of Pathology
https://read.qxmd.com/read/37980071/correction
#44
(no author information available yet)
No abstract text is available yet for this article.
December 2023: American Journal of Pathology
https://read.qxmd.com/read/37734590/tumor-infiltrating-lymphocyte-recognition-in-primary-melanoma-by-deep-learning-convolutional-neural-network
#45
JOURNAL ARTICLE
Filippo Ugolini, Francesco De Logu, Luigi Francesco Iannone, Francesca Brutti, Sara Simi, Vincenza Maio, Vincenzo de Giorgi, Anna Maria di Giacomo, Clelia Miracco, Francesco Federico, Ketty Peris, Giuseppe Palmieri, Antonio Cossu, Mario Mandalà, Daniela Massi, Marco Laurino
The presence of tumor-infiltrating lymphocytes (TILs) is associated with a favorable prognosis of primary melanoma (PM). Recently, artificial intelligence (AI)-based approach in digital pathology was proposed for the standardized assessment of TILs on hematoxylin and eosin-stained whole slide images (WSIs). Herein, the study applied a new convolution neural network (CNN) analysis of PM WSIs to automatically assess the infiltration of TILs and extract a TIL score. A CNN was trained and validated in a retrospective cohort of 307 PMs including a training set (237 WSIs, 57,758 patches) and an independent testing set (70 WSIs, 29,533 patches)...
December 2023: American Journal of Pathology
https://read.qxmd.com/read/37717940/estrogen-related-receptor-agonism-reverses-mitochondrial-dysfunction-and-inflammation-in-the-aging-kidney
#46
JOURNAL ARTICLE
Xiaoxin X Wang, Komuraiah Myakala, Andrew E Libby, Ewa Krawczyk, Julia Panov, Bryce A Jones, Kanchan Bhasin, Nataliia Shults, Yue Qi, Kristopher W Krausz, Patricia M Zerfas, Shogo Takahashi, Parnaz Daneshpajouhnejad, Avi Titievsky, Elizaveta Taranenko, Cyrielle Billon, Arindam Chatterjee, Bahaa Elgendy, John K Walker, Chris Albanese, Jeffrey B Kopp, Avi Z Rosenberg, Frank J Gonzalez, Udayan Guha, Leonid Brodsky, Thomas P Burris, Moshe Levi
A gradual decline in renal function occurs even in healthy aging individuals. In addition to aging, per se, concurrent metabolic syndrome and hypertension, which are common in the aging population, can induce mitochondrial dysfunction and inflammation, which collectively contribute to age-related kidney dysfunction and disease. This study examined the role of the nuclear hormone receptors, the estrogen-related receptors (ERRs), in regulation of age-related mitochondrial dysfunction and inflammation. The ERRs were decreased in both aging human and mouse kidneys and were preserved in aging mice with lifelong caloric restriction (CR)...
December 2023: American Journal of Pathology
https://read.qxmd.com/read/37689385/the-role-of-endoplasmic-reticulum-in-lipotoxicity-during-metabolic-dysfunction-associated-steatotic-liver-disease-masld-pathogenesis
#47
REVIEW
Nanditha Venkatesan, Luke C Doskey, Harmeet Malhi
Perturbations in lipid and protein homeostasis induce endoplasmic reticulum (ER) stress in metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease. Lipotoxic and proteotoxic stress can activate the unfolded protein response (UPR) transducers: inositol requiring enzyme1α, PKR-like ER kinase, and activating transcription factor 6α. Collectively, these pathways induce expression of genes that encode functions to resolve the protein folding defect and ER stress by increasing the protein folding capacity of the ER and degradation of misfolded proteins...
December 2023: American Journal of Pathology
https://read.qxmd.com/read/37673331/adolescence-and-the-microbiome-implications-for-healthy-growth-and-maturation
#48
REVIEW
Matthew D Carson, Caroline Westwater, Chad M Novince
The gut microbiota was initially thought to develop into a stable, adult-like profile during early postnatal life. The formation of the gut microbiota during early life has been shown to contribute to healthy growth and has lifelong implications for host health. Adolescence, the developmental period between childhood and adulthood, is a critical window for healthy growth and maturation. The composition of the gut microbiota in adolescents is distinct from that of children and adults, which supports the premise that the gut microbiota continues to develop during adolescence toward an adult-like profile...
December 2023: American Journal of Pathology
https://read.qxmd.com/read/37673327/domain-and-histopathology-adaptations-based-classification-for-malignancy-grading-system
#49
JOURNAL ARTICLE
Vicky Mudeng, Mifta Nur Farid, Gelan Ayana, Se-Woon Choe
Accurate proliferation rate quantification can be used to devise an appropriate treatment for breast cancer. Pathologists use breast tissue biopsy glass slides stained with hematoxylin and eosin to obtain grading information. However, this manual evaluation may lead to high costs and be ineffective because diagnosis depends on the facility and the pathologists' insights and experiences. Convolutional neural network acts as a computer-based observer to improve clinicians' capacity in grading breast cancer. Therefore, this study proposes a novel scheme for automatic breast cancer malignancy grading from invasive ductal carcinoma...
December 2023: American Journal of Pathology
https://read.qxmd.com/read/37544502/standardized-classification-of-lung-adenocarcinoma-subtypes-and-improvement-of-grading-assessment-through-deep-learning
#50
JOURNAL ARTICLE
Kris Lami, Noriaki Ota, Shinsuke Yamaoka, Andrey Bychkov, Keitaro Matsumoto, Wataru Uegami, Jijgee Munkhdelger, Kurumi Seki, Odsuren Sukhbaatar, Richard Attanoos, Sabina Berezowska, Luka Brcic, Alberto Cavazza, John C English, Alexandre Todorovic Fabro, Kaori Ishida, Yukio Kashima, Yuka Kitamura, Brandon T Larsen, Alberto M Marchevsky, Takuro Miyazaki, Shimpei Morimoto, Mutsumi Ozasa, Anja C Roden, Frank Schneider, Maxwell L Smith, Kazuhiro Tabata, Angela M Takano, Tomonori Tanaka, Tomoshi Tsuchiya, Takeshi Nagayasu, Hidenori Sakanashi, Junya Fukuoka
The histopathologic distinction of lung adenocarcinoma (LADC) subtypes is subject to high interobserver variability, which can compromise the optimal assessment of patient prognosis. Therefore, this study developed convolutional neural networks capable of distinguishing LADC subtypes and predicting disease-specific survival, according to the recently established LADC tumor grades. Consensus LADC histopathologic images were obtained from 17 expert pulmonary pathologists and one pathologist in training. Two deep learning models (AI-1 and AI-2) were trained to predict eight different LADC classes...
December 2023: American Journal of Pathology
https://read.qxmd.com/read/38040091/high-mannose-type-glycan-of-basigin-in-endothelial-cells-is-essential-for-the-opening-of-blood-brain-barrier-induced-by-hypoxia-cyclophilin-a-or-tnf-%C3%AE
#51
JOURNAL ARTICLE
Dan Cui, Kazuo Yamamoto, Eiji Ikeda
Pathological opening of blood-brain barrier accelerates the progression of various neural diseases. As an essential molecule for the opening of blood-brain barrier, we have specified basigin, a highly glycosylated transmembrane molecule, in barrier-forming endothelial cells. Here, we analyzed the involvement of basigin in the regulation of blood-brain barrier focusing on its glycosylation forms. First, basigin was found to be expressed as the cell surface molecules with complex-type glycan as well as those with high mannose-type glycan in barrier-forming endothelial cells...
November 29, 2023: American Journal of Pathology
https://read.qxmd.com/read/38029923/multilamellated-basement-membranes-in-the-capillary-network-of-alveolar-capillary-dysplasia
#52
JOURNAL ARTICLE
Jan C Kamp, Lavinia Neubert, Jonas C Schupp, Peter Braubach, Christoph Wrede, Florian Laenger, Tim Salditt, Jakob Reichmann, Tobias Welte, Arjang Ruhparwar, Fabio Ius, Nicolaus Schwerk, Anke K Bergmann, Sandra von Hardenberg, Matthias Griese, Christina Rapp, Karen M Olsson, Jan Fuge, Da-Hee Park, Marius M Hoeper, Danny D Jonigk, Lars Knudsen, Mark P Kuehnel
A minimal diffusion barrier is key to the pulmonary gas exchange. In alveolar capillary dysplasia (ACD), a rare genetically driven disease of early infancy, this crucial fibrovascular interface is compromised while the underlying pathophysiology is insufficiently understood. Recent in-depth analyses of vascular alterations in adult lung disease encouraged to extend these studies to ACD and compare the changes of the microvasculature. Lung tissue samples of children with ACD (n=12), adults with non-specific interstitial pneumonia (n=12), and controls (n=20) were studied using single gene sequencing, immunostaining, exome sequencing, and broad transcriptome profiling in addition to analysis of the vasculature by transmission electron microscopy...
November 27, 2023: American Journal of Pathology
https://read.qxmd.com/read/38029922/non-metastatic-axillary-lymph-nodes-have-distinct-morphology-and-immunophenotype-in-obese-breast-cancer-patients-at-risk-for-metastasis
#53
JOURNAL ARTICLE
Qingyuan Song, Kristen E Muller, Liesbeth M Hondelink, Roberta M diFlorio-Alexander, Margaret Karagas, Saeed Hassanpour
Obese breast cancer patients have worse outcomes than their normal weight counterparts, with a 50% to 80% increased rate of axillary nodal metastasis. Recent studies suggest a link between increased lymph node adipose tissue and breast cancer nodal metastasis. Further investigation into potential mechanisms underlying this link may reveal potential prognostic utility of fat-enlarged lymph nodes in breast cancer patients. This study uses a deep learning model to identify morphological differences in non-metastatic axillary nodes between obese, node-positive and node-negative breast cancer patients...
November 27, 2023: American Journal of Pathology
https://read.qxmd.com/read/38029921/maternal-obesogenic-diet-attenuates-microbiome-dependent-offspring-weaning-reaction-with-worsening-of-steatotic-liver-disease
#54
JOURNAL ARTICLE
Vung Lian, Holly Hinrichs, Monica Young, Austin Faerber, Oğuz Özler, Yan Xie, Samuel J Ballentine, Phillip I Tarr, Nicholas O Davidson, Michael D Thompson
The mechanisms by which maternal obesity increases the susceptibility to steatotic liver disease (SLD) in offspring are incompletely understood and models using different maternal obesogenic diets (MODEs) display phenotypic variability, likely reflecting the influence of timing and diet composition. Here we compare three maternal obesogenic diets using standardized exposure times to identify differences in offspring disease progression. We found that the severity of hepatic inflammation and fibrosis in offspring depends on the composition of maternal obesogenic diet...
November 27, 2023: American Journal of Pathology
https://read.qxmd.com/read/37995836/substance-p-increases-stat6-mediated-transcription-activation-of-lcp2-to-sustain-m2-macrophage-predominance-in-pediatric-asthma
#55
JOURNAL ARTICLE
Miao Li, Xiao Zhong, Wenting Xu
Substance P (SP) is a neuropeptide released by neurons and participates in various biological processes, including inflammation. M2 macrophages are major immune cells associated with type 2 inflammation in asthma. This study investigates the effect of SP on macrophage phenotype in pediatric asthma and the underpinning factors. Asthmatic children exhibited an increased level of SP, along with a higher proportion of M2 macrophages in their bronchoalveolar lavage fluid (BALF). Flow cytometry revealed that SP treatment enhanced the M2 polarization of TPA-treated THP-1 cells (macrophages) in vitro...
November 21, 2023: American Journal of Pathology
https://read.qxmd.com/read/37981221/release-of-mir-29-target-laminin-c2-improves-skin-repair
#56
JOURNAL ARTICLE
Connor James Robinson, Lalitha Thiagarajan, Rebecca Maynard, Maneesha Aruketty, Jeremy Herrera, Lewis Dingle, Adam Reid, Jason Wong, Heng Cao, James Dooley, Adrian Liston, Daniela Müllhaupt, Paul Hiebert, Hayley Hiebert, Svitlana Kurinna
MicroRNAs (miRs) are small non-coding RNAs that regulate mRNA targets in a cell-specific manner. miR-29 is expressed in mouse and human skin where it may regulate functions important for skin repair. Cutaneous wound healing model in miR29ab1 knockout (KO) mice was used to identify miR-29 targets in the wound matrix, where angiogenesis and maturation of provisional granulation tissue was enhanced in response to genetic deletion of miR-29. Consistently, antisense-mediated inhibition of miR-29 promoted angiogenesis in vitro by autocrine and paracrine mechanisms...
November 17, 2023: American Journal of Pathology
https://read.qxmd.com/read/37981220/foxo3-activated-hottip-sequesters-mir-615-3p-away-from-col2a1-to-mitigate-intervertebral-disc-degeneration
#57
JOURNAL ARTICLE
Yingjie Hao, Guangduo Zhu, Lei Yu, Zhinan Ren, Weiwei Zhou, Panke Zhang, Xu Lian
Knockout of FOXO3 was found to impair IVD maturation and homeostasis in postnatal mice as well as facilitating extracellular matrix (ECM) degradation. RNA sequencing can uncover disease-related gene expression and investigate disease pathophysiology. High-throughput transcriptome sequencing and experimental validations were used to identify the essential gene and mechanism involved in intervertebral disc degeneration (IDD). Nucleus pulposus (NP) tissue samples were collected from the mice with conditional knockout of FOXO3 (FOXO3 KO) for high-throughput sequencing, followed by screening of differentially expressed lncRNAs and mRNAs...
November 17, 2023: American Journal of Pathology
https://read.qxmd.com/read/37981219/insight-into-the-role-of-gut-microbiota-in-duchenne-muscular-dystrophy-an-age-related-study-in-mdx-mice
#58
JOURNAL ARTICLE
Maxence Jollet, Mahendra Mariadassou, Olivier Rué, Laurence Pessemesse, Vincent Ollendorff, Sofiane Ramdani, Barbara Vernus, Anne Bonnieu, Christelle Bertrand-Gaday, Bénédicte Goustard, Christelle Koechlin-Ramonatxo
Dystrophin deficiency alters the sarcolemma structure leading to muscle dystrophy, muscle disuse and ultimately death. Beyond limb muscle deficits, patients with Duchenne muscular dystrophy have many transit disorders. Many studies highlighted the strong relationship between gut microbiota and skeletal muscle. The aims of this study were i) to characterize the gut microbiota composition over time up to 1 years-old, in dystrophin-deficient mdx mice; ii) to analyse the intestine structure-function and expression of genes linked to bacterial-derived metabolites in ileum, blood, tibial anterior and soleus muscles to study inter-organ interactions...
November 17, 2023: American Journal of Pathology
https://read.qxmd.com/read/37956969/this-month-in-ajp
#59
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 10, 2023: American Journal of Pathology
https://read.qxmd.com/read/37925018/hepatic-transcriptome-and-its-regulation-following-soluble-epoxide-hydrolase-inhibition-in-alcohol-associated-liver-disease
#60
JOURNAL ARTICLE
Jeffrey B Warner, Josiah E Hardesty, Ying L Song, Alison T Floyd, Zhongbin Deng, Audriy Jebet, Liqing He, Xiang Zhang, Craig J McClain, Bruce D Hammock, Dennis R Warner, Irina A Kirpich
Alcohol-associated liver disease (ALD) is a serious public health problem with limited pharmacological options. The goal of the current study was to investigate the efficacy of pharmacological inhibition of soluble epoxide hydrolase (sEH, an enzyme involved in lipid metabolism) in experimental ALD and to examine the underlying mechanisms. C57BL/6J male mice underwent acute-on-chronic ethanol (EtOH) feeding with or without the sEH inhibitor, TUCB. Liver injury was assessed by multiple end-points. Liver epoxy- and dihydroxy-fatty acids were measured by targeted metabolomics...
November 2, 2023: American Journal of Pathology
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