journal
https://read.qxmd.com/read/38734137/this-month-in-ajp
#21
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
May 9, 2024: American Journal of Pathology
https://read.qxmd.com/read/38705384/atgl-mediated-adipocyte-lipolysis-exacerbates-acute-pancreatitis-severity-in-mouse-models-and-patients
#22
JOURNAL ARTICLE
Xiaochun Xie, Yang Liu, Qi Yang, Xiaojie Ma, Yingying Lu, Yuepeng Hu, Guofu Zhang, Lu Ke, Zhihui Tong, Yuxiu Liu, Jing Xue, Guotao Lu, Weiqin Li
Dyslipolysis of adipocytes has played a critical role in various diseases. Adipose triglyceride lipase (ATGL) is a rate-limiting enzyme in adipocyte autonomous lipolysis. However, whether the degree of adipocyte lipolysis relates to the prognoses in acute pancreatitis (AP) and the role of ATGL mediated lipolysis in the pathogenesis of AP remains elusive. The visceral adipose tissue (VAT) consumption rate (VATR) in the acute stage was measured in both AP patients and mouse models. Lipolysis levels and ATGL expression were detected in caerulein (CER)-induced AP models...
May 3, 2024: American Journal of Pathology
https://read.qxmd.com/read/38705383/a-novel-role-for-the-phosphatidylinositol-4-5-bisphosphate-3-kinase-delta-isoform-in-hepatocellular-proliferation
#23
JOURNAL ARTICLE
Nicole J Martucci, John Stoops, William Bowen, Anne Orr, Mary-Claire Cotner, George K Michalopoulos, Bharat Bhushan, Wendy M Mars
The phosphatidylinositol-4,5-bisphosphate 3-kinase delta isoform (Pik3cd), usually considered immune-specific, was unexpectedly identified as a gene potentially related to either regeneration and/or differentiation in animals lacking hepatocellular Integrin Linked Kinase (ILK). Since a specific inhibitor (Idelalisib, or CAL101) for the catalytic subunit encoded by Pik3cd (p110δ) has reported hepatotoxicity when used for treating Chronic Lymphocytic Leukemia and other lymphomas, we aimed to elucidate if there is a role for p110δ in normal liver function...
May 3, 2024: American Journal of Pathology
https://read.qxmd.com/read/38705382/latent-transforming-growth-factor-%C3%AE-binding-protein-1-transforming-growth-factor-%C3%AE-1-complex-drives-antitumoral-effects-upon-erk5-targeting-in-melanoma
#24
JOURNAL ARTICLE
Alessandro Tubita, Alessio Menconi, Zoe Lombardi, Ignazia Tusa, Azucena Esparís-Ogando, Atanasio Pandiella, Tania Gamberi, Barbara Stecca, Elisabetta Rovida
Melanoma is the deadliest skin cancer, with a poor prognosis in advanced stages. Available treatments have improved the survival, although long-term benefits are still unsatisfactory. The mitogen-activated protein kinase ERK5 promotes melanoma growth, and ERK5 inhibition determines cellular senescence and the senescence-associated secretory phenotype. Here, latent-transforming growth factor β-binding protein 1 (LTBP1) mRNA was found to be upregulated in A375 and SK-Mel-5 BRAFV600E melanoma cells after ERK5 inhibition...
May 3, 2024: American Journal of Pathology
https://read.qxmd.com/read/38705381/dysregulation-of-the-long-non-coding-rna-xist-expression-in-male-patients-with-pulmonary-arterial-hypertension
#25
JOURNAL ARTICLE
Brandon L Carman, Shanshan Qin, Dan N Predescu, Malabendu Jana, Rene Cortese, Micheala A Aldred, David Gozal, Babak Mokhlesi, Sanda A Predescu
Pulmonary arterial hypertension (PAH) is a sex-biased disease with female gender as a significant risk factor. Recently, we reported that increased expression of the long non-coding (lnc)RNA Xist, as induced by an intersectin-1s protein fragment with proliferative potential (EHITSN ), may explain the sexual dimorphism of female pulmonary artery endothelial cells (ECs) and at least in part, the imbalance sex/ratio of PAH. Xist is essential for X-chromosome inactivation and dosage compensation of X-linked genes...
May 3, 2024: American Journal of Pathology
https://read.qxmd.com/read/38705380/the-role-of-pericytes-in-lipopolysaccharide-induced-murine-acute-respiratory-distress-syndrome
#26
JOURNAL ARTICLE
Bartosz Mierzejewski, Justyna Różycka, Władysława Stremińska, Aneta Brągiel-Pieczonka, Karolina Sidor, Grażyna Hoser, Zbigniew Bartoszewicz, Magdalena Gewartowska, Małgorzata Frontczak-Baniewicz, Maria Anna Ciemerych, Edyta Brzóska, Tomasz Skirecki
Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome that is most commonly triggered by infection-related inflammation. Lung pericytes can respond to infection and act as immune and proangiogenic cells; moreover, these cells can differentiate into myofibroblasts in nonresolving ARDS and contribute to the development of pulmonary fibrosis. Here, we aimed to characterize the role of lung cells, which present characteristics of pericytes, such as peri-endothelial location and expression of a panel of specific markers...
May 3, 2024: American Journal of Pathology
https://read.qxmd.com/read/38704091/the-transcriptional-landscape-of-coding-and-non-coding-rnas-in-recurrent-and-non-recurrent-colon-cancer
#27
JOURNAL ARTICLE
Ulrik Korsgaard, Juan L García-Rodríguez, Theresa Jakobsen, Ulvi Ahmadov, Kim-Gwendolyn Dietrich, Stine Mary Vissing, Thea Petersen Paasch, Jan Lindebjerg, Jørgen Kjems, Henrik Hager, Lasse Sommer Kristensen
A considerable number of colon cancer patients with local or local advanced disease suffer from recurrence and there is an urgent need for better prognostic biomarkers in this setting. Here, the transcriptomic landscape of messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs), small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), small Cajal body-specific RNAs (scaRNAs), pseudogenes and circular RNAs (circRNAs), as well as RNAs denoted as miscellaneous RNAs, was profiled by total RNA sequencing. In addition to well-known coding and non-coding RNAs, differential expression analysis also uncovered transcripts, which have not previously been implicated in colon cancer, such as RNA5SP149, RNU4-2 and SNORD3A...
May 2, 2024: American Journal of Pathology
https://read.qxmd.com/read/38697513/finding-your-car-the-road-ahead-for-engineered-t-cells
#28
REVIEW
Po-Han Chen, Rianna Raghunandan, Jon S Morrow, Samuel G Katz
Adoptive cellular therapy using chimeric antigen receptors (CAR) has transformed immunotherapy by engineering T cells to target specific antigens on tumor cells. As the field continues to advance, pathology laboratories will play increasingly essential roles in the complicated multi-step process of CAR-T therapy. These include the detection of targetable tumor antigens by flow cytometry or immunohistochemistry at the time of disease diagnosis and the isolation and infusion of CAR-T cells. Additional roles include (1) detecting antigen loss or heterogeneity that renders resistance to CAR-T as well as identifying alternative targetable antigens on tumor cells, (2) monitoring the phenotype, persistence and tumor infiltration properties of CAR T-cells and the tumor microenvironment for factors that predict CAR-T success, and (3) evaluating side effects and biomarkers of CAR-T cytotoxicity such as cytokine release syndrome...
April 30, 2024: American Journal of Pathology
https://read.qxmd.com/read/38670529/modulating-pcgf4-stability-is-an-efficient-metastasis-regulatory-strategy-utilized-by-distinct-subtypes-of-cancer-associated-fibroblasts-in-intrahepatic-cholangiocarcinoma
#29
JOURNAL ARTICLE
Jinjing Hu, Hao Xu, Xiaojun Ma, Mingzhen Bai, Yongqiang Zhou, Ruidong Miao, Fanghong Wang, Xun Li, Bo Cheng
Intrahepatic Cholangiocarcinoma (ICC) is highly malignant neoplasm and prone to metastasis. It is unclear if cancer-associated fibroblasts (CAFs) affect the metastasis of ICC. Here, we have established ICC patient-derived CAF lines and related cancerous cell lines and analyzed the effects of CAFs on the tumor progressive properties of the ICC cancerous cells. Results demonstrated that CAFs can be classified into cancer-restraining or promoting categories (rCAFs or pCAFs) based on distinct tumorigenic effects...
April 24, 2024: American Journal of Pathology
https://read.qxmd.com/read/38657836/integrated-bioinformatics-and-machine-learning-analysis-identify-acadl-as-a-potent-biomarker-of-reactive-mesothelial-cells
#30
JOURNAL ARTICLE
Yige Yin, Qianwen Cui, Jiarong Zhao, Qiang Wu, Qiuyan Sun, Hong-Qiang Wang, Wulin Yang
Mesothelial cells with reactive hyperplasia are difficult to distinguish from malignant mesothelioma cells on cell morphology. This study aimed to identify and validate potential biomarkers that distinguish mesothelial cells from mesothelioma cells through machine learning combined with immunohistochemistry (IHC) experiments. We integrated the gene expression matrix from three GEO datasets (GSE2549, GSE12345, GSE51024) to analyze the differently expressed gene (DEGs) between normal and mesothelioma tissues...
April 22, 2024: American Journal of Pathology
https://read.qxmd.com/read/38880601/identification-of-htra4-as-a-transcriptional-target-of-p63-in-trophoblast
#31
JOURNAL ARTICLE
Mary E Donohoe, Robert Morey, Yingchun Li, Donald Pizzo, Sampada Kallol, Hee-Young Cho, Francesca Soncin, Mana M Parast
The placenta plays a crucial role in pregnancy success. ΔNp63α (p63), a transcription factor from the TP53 family, is highly expressed in villous cytotrophoblasts (CTBs), the epithelial stem cells of the human placenta, and is involved in CTB maintenance and differentiation. We examined the mechanisms of action of p63 by identifying its downstream targets. Gene expression changes were evaluated following overexpression and knockdown of p63 in the JEG3 choriocarcinoma cell line, using microarray-based RNA profiling...
July 2024: American Journal of Pathology
https://read.qxmd.com/read/38749612/correction
#32
(no author information available yet)
No abstract text is available yet for this article.
June 2024: American Journal of Pathology
https://read.qxmd.com/read/38749611/authors-reply
#33
LETTER
Calen A Steiner, Sean P Colgan
No abstract text is available yet for this article.
June 2024: American Journal of Pathology
https://read.qxmd.com/read/38749610/re-evaluating-the-conclusions-of-the-study-by-steiner-et-al-insufficient-evidence-to-support-tnf-%C3%AE-are-mice-as-a-model-of-intestinal-fibrosis
#34
LETTER
Lida Iliopoulou, Vasiliki Koliaraki, Giorgios Bamias, George Kollias
No abstract text is available yet for this article.
June 2024: American Journal of Pathology
https://read.qxmd.com/read/38749609/isolation-and-characterization-of-a-novel-mammary-adenocarcinoma-mca-p1362-with-hormone-receptor-expression-human-epidermal-growth-factor-receptor-2-positivity-and-enrichment-in-cancer-and-mesenchymal-stem-cells
#35
JOURNAL ARTICLE
Samir Jana, Wende Li, Pin-Ji Lei, Zixiong Wang, Shaye Kibara, Peigen Huang, Dennis Jones
Preclinical models that display spontaneous metastasis are necessary to improve the therapeutic options for hormone receptor-positive breast cancers. Within this study, detailed cellular and molecular characterization was conducted on MCa-P1362, a newly established mouse model of metastatic breast cancer that is syngeneic in BALB/c mice. MCa-P1362 cancer cells express estrogen receptor, progesterone receptor, and the human epidermal growth factor receptor 2. MCa-P1362 cancer cells proliferate in vitro and in vivo in response to estrogen, yet do not depend on steroid hormones for growth and tumor progression...
June 2024: American Journal of Pathology
https://read.qxmd.com/read/38749608/suppression-of-n-glycosylation-of-zinc-finger-protein-471-affects-proliferation-invasion-and-docetaxel-sensitivity-of-tongue-squamous-cell-carcinoma-via-regulation-of-c-myc
#36
JOURNAL ARTICLE
Yan Liu, Xu Cai, Shousen Hu, Zhen Wang, Hao Tian, Honghan Wang
Zinc finger protein 471 (ZNF471) is a member of the Krüppel-related domain zinc finger protein family, and has recently attracted attention because of its anti-cancer effects. N-glycosylation regulates expression and functions of the protein. This study aimed to investigate the effects of ZNF471 N-glycosylation on the proliferation, invasion, and docetaxel sensitivity of tongue squamous cell carcinoma (TSCC). It analyzed the expression, function, and prognostic significance of ZNF471 in TSCC using bioinformatics techniques such as gene differential expression analysis, univariate Cox regression analysis, functional enrichment analysis, and gene set enrichment analysis...
June 2024: American Journal of Pathology
https://read.qxmd.com/read/38637109/uremia-impedes-skeletal-myocyte-myomixer-expression-and-fusogenic-activity-implication-for-uremic-sarcopenia
#37
JOURNAL ARTICLE
Takaaki Higashihara, Motoki Odawara, Hiroshi Nishi, Takehito Sugasawa, Yumika Suzuki, Satoshi Kametaka, Reiko Inagi, Masaomi Nangaku
In patients with chronic kidney disease (CKD), skeletal muscle mass and function are known to occasionally decline. However, the muscle regeneration and differentiation process in uremia has not been extensively studied. In mice with CKD induced by adenine-containing diet, the tibialis anterior muscle injured using a barium chloride injection method recovered poorly as compared to control mice. In the cultured murine skeletal myocytes, stimulation with indoxyl sulfate (IS), a representative uremic toxin, morphologically jeopardized the differentiation, which was counteracted by L-ascorbic acid (L-AsA) treatment...
May 2024: American Journal of Pathology
https://read.qxmd.com/read/38382842/a-histopathologic-image-analysis-for-the-classification-of-endocervical-adenocarcinoma-silva-patterns-depend-on-weakly-supervised-deep-learning
#38
JOURNAL ARTICLE
Qingqing Liu, Xiaofang Zhang, Xuji Jiang, Chunyan Zhang, Jiamei Li, Xuedong Zhang, Jingyan Yang, Ning Yu, Yongcun Zhu, Jing Liu, Fengxiang Xie, Yawen Li, Yiping Hao, Yuan Feng, Qi Wang, Qun Gao, Wenjing Zhang, Teng Zhang, Taotao Dong, Baoxia Cui
Twenty-five percent of cervical cancers are classified as endocervical adenocarcinomas (EACs), which comprise a highly heterogeneous group of tumors. A histopathologic risk stratification system known as the Silva pattern system was developed based on morphology. However, accurately classifying such patterns can be challenging. The study objective was to develop a deep learning pipeline (Silva3-AI) that automatically analyzes whole slide image-based histopathologic images and identifies Silva patterns with high accuracy...
May 2024: American Journal of Pathology
https://read.qxmd.com/read/38325553/transient-receptor-potential-vanilloid-1-channels-facilitate-axonal-degeneration-of-corneal-sensory-nerves-in-dry-eye
#39
JOURNAL ARTICLE
Manuela Pizzano, Alexia Vereertbrugghen, Agostina Cernutto, Florencia Sabbione, Irene A Keitelman, Carolina M Shiromizu, Douglas Vera Aguilar, Federico Fuentes, Mirta N Giordano, Analía S Trevani, Jeremías G Galletti
Corneal nerve impairment contributes significantly to dry eye disease (DED) symptoms and is thought to be secondary to corneal epithelial damage. Transient receptor potential vanilloid-1 (TRPV1) channels abound in corneal nerve fibers and respond to inflammation-derived ligands, which increase in DED. TRPV1 overactivation promotes axonal degeneration in vitro, but whether it participates in DED-associated corneal nerve dysfunction is unknown. To explore this, DED was surgically induced in wild-type and TRPV1-knockout mice, which developed comparable corneal epithelial damage and reduced tear secretion...
May 2024: American Journal of Pathology
https://read.qxmd.com/read/38631549/stromal-rigidity-stress-accelerates-pancreatic-intraepithelial-neoplasia-progression-and-chromosomal-instability-via-nuclear-ptk2-localization
#40
JOURNAL ARTICLE
Li-Yun Ding, Chia-Jung Chang, Szu-Ying Chen, Kuan-Lin Chen, Yueh-Shan Li, Yun-Chieh Wu, Ting-Yi Hsu, Hsin-Yu Ying, Hsin-Yi Wu, Michael W Hughes, Chia-Yih Wang, Chih-Han Chang, Ming-Jer Tang, Woei-Jer Chuang, Yan-Shen Shan, Chia-Jung Chang, Po-Hsien Huang
Since the mechanotransduction by stromal stiffness stimulates the rupture and repair of the nuclear envelope in pancreatic progenitor cells, accumulated genomic aberrations are under selection in the tumor microenvironment. Analysis of cell growth, micronuclei, and γH2AX foci links to mechanotransduction pressure in vivo during serial orthotopic passages of mouse KrasLSL-G12D/+ ;Trp53flox/flox ;Pdx1-Cre (KPC) cancer cells in the tumor and in migrating through the size-restricted 3μm micropores. To search for pancreatic cancer cell-of-origin, analysis of single-cell datasets revealed that the ECM shapes an alternate route of acinar-ductal transdifferentiation of acinar cells into a central hub of elegantly restrained TOP2A-overexpressing cancer cells that spread out as unique cancer clusters with copy number amplifications in MYC-PTK2 locus and PIK3CA...
April 15, 2024: American Journal of Pathology
journal
journal
20018
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.