Stefan C Halvorsen, Yair Benita, Megan Hopton, Brooke Hoppe, Hilmar Orn Gunnlaugsson, Parimal Korgaonkar, Charles R Vanderburg, G Petur Nielsen, Nicole Trepanowski, Jaime H Cheah, Matthew P Frosch, Joseph H Schwab, Andrew E Rosenberg, Francis J Hornicek, Slim Sassi
Chordoma is a rare malignant tumor demonstrating notochordal differentiation. It is dependent on Brachyury (TBXT), a hallmark notochordal gene and transcription factor, and shares histological features and the same anatomical location as the notochord. In this study, we perform a molecular comparison of chordoma and notochord to identify dysregulated cellular pathways. The lack of a molecular reference from appropriate control tissue limits our understanding of chordoma and its relationship to notochord. Accordingly, we conducted an unbiased comparison of chordoma, human notochord, and an atlas of normal and cancerous tissue using gene expression profiling to clarify the chordoma/notochord relationship and potentially identify novel drug targets...
February 17, 2023: American Journal of Pathology