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American Journal of Geriatric Psychiatry

https://read.qxmd.com/read/37741764/identifying-and-diagnosing-tdp-43-neurodegenerative-diseases-in-psychiatry
#1
REVIEW
Simon Ducharme, Yolande Pijnenburg, Jonathan D Rohrer, Edward Huey, Elizabeth Finger, Nadine Tatton
Neuropsychiatric symptoms (NPS) are common manifestations of neurodegenerative disorders and are often early signs of those diseases. Among those neurodegenerative diseases, TDP-43 proteinopathies are an increasingly recognized cause of early neuropsychiatric manifestations. TDP-43-related diseases include frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE). The majority of TDP-43-related diseases are sporadic, but a significant proportion is hereditary, with progranulin (GRN) mutations and C9orf72 repeat expansions as the most common genetic etiologies...
September 3, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37718134/white-noise-is-anxiety-in-late-life-associated-with-white-matter-hyperintensity-burden
#2
JOURNAL ARTICLE
Andrew R Gerlach, Helmet T Karim, Soyoung Lee, Antonija Kolobaric, Dana L Tudorascu, Meryl A Butters, Carmen Andreescu
OBJECTIVE: We investigated the relationship between anxiety phenotypes (global anxiety, worry, and rumination) and white matter hyperintensities (WMH), with special consideration for the roles of age and executive function (EF). Our hypotheses were 1) anxiety phenotypes would be associated with WMH and 2) EF would moderate this relationship. DESIGN: Cross-sectional. SETTING: Participants were recruited from the local community (Pittsburgh, PA)...
August 27, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37689532/effect-of-muscle-mass-and-strength-on-depression-does-mendelian-randomization-address-causality
#3
EDITORIAL
Candida J Rebello
No abstract text is available yet for this article.
August 23, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37690981/association-of-7-day-follow-up-with-6-month-suicide-mortality-following-hospitalization-for-suicidal-thoughts-or-behaviors-among-older-adults
#4
JOURNAL ARTICLE
Timothy Schmutte, Mark Olfson, Ming Xie, Steven C Marcus
OBJECTIVE: To evaluate whether timely follow-up outpatient mental health care is associated with reduced short-term suicide risk following hospitalization for suicidal thoughts or behaviors. METHODS: Retrospective cohort analysis using 2015 Medicare data for adults aged ≥ 65 years who were hospitalized for suicidal ideation or behaviors (n = 36,557) linked with the National Death Index. Adjusted risk ratios (ARR) estimated the association between 7-day follow-up and suicide risk at 30-, 90-, and 180-days, adjusted for confounding by indication using inverse probability of treatment weights of observable covariates...
August 22, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37684186/the-antidepressant-effects-of-glp-1-receptor-agonists-a-systematic-review-and-meta-analysis
#5
REVIEW
Xinda Chen, Peiyi Zhao, Weihao Wang, Lixin Guo, Qi Pan
AIM/HYPOTHESIS: Emerging evidence suggests that glucagon-like peptide-1 receptor agonists (GLP-1RAs) may exert positive effects in patients with depression. Our aim was to conduct a systematic review and meta-analysis to examine the antidepressant effects of GLP-1RAs. METHODS: Randomized controlled trials and prospective cohort studies investigating the effects of GLP-1RAs versus placebo or other antidiabetic therapies on depressive symptoms were searched for using multiple electronic sources (CENTRAL, PubMed, EMBASE, PsycINFO, World Health Organization International Clinical Trials Registry Platform, ClinicalTrials...
August 21, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37716824/regrets
#6
EDITORIAL
David L Coulter
No abstract text is available yet for this article.
August 19, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37704458/remaining-questions-in-a-brave-new-world-of-alzheimer-s-disease-care
#7
EDITORIAL
Joshua D Grill
No abstract text is available yet for this article.
August 19, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37640578/presidential-address-reimagining-the-field-of-geriatric-psychiatry-in-the-2020-2030-decade-of-healthy-aging-focus-on-innovation-to-promote-brain-health-and-well-being-in-aging-adults-and-caregivers
#8
EDITORIAL
https://read.qxmd.com/read/37709588/running
#9
EDITORIAL
David L Coulter
No abstract text is available yet for this article.
August 17, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37634955/-and-does-that-necessarily-mean-absolutely-alzheimer-s-an-analysis-of-questions-raised-following-amyloid-pet-results-disclosure
#10
JOURNAL ARTICLE
Jeong Eun Kim, Lisa K Tamres, Staci L Orbell, Rebekah Z Cheng, William E Klunk, Howard J Aizenstein, Meryl A Butters, Eric McDade, Jennifer H Lingler
INTRODUCTION: Amyloid PET scans provide individuals with mild cognitive impairment (MCI) information about their risk of progressing to Alzheimer's dementia (AD). Given the wide-ranging implications of this information, best practice guidelines are needed to support researchers and clinicians disclosing these high-stakes test results. To inform the development of such guidelines, this analysis aims to describe questions and concerns raised during the disclosure of amyloid PET results in the context of MCI...
August 13, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37626003/resilience-and-the-covid-pandemic
#11
EDITORIAL
Dan G Blazer
No abstract text is available yet for this article.
August 13, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37673749/assessment-of-gray-matter-microstructure-and-synaptic-density-in-alzheimer-s-disease-a-multimodal-imaging-study-with-dti-and-sv2a-pet
#12
JOURNAL ARTICLE
Jason A Silva-Rudberg, Elaheh Salardini, Ryan S O'Dell, Ming-Kai Chen, Jocelyn Ra, Jamie K Georgelos, Mackenzie R Morehouse, Kaitlyn P Melino, Pradeep Varma, Takuya Toyonaga, Nabeel B Nabulsi, Yiyun Huang, Richard E Carson, Christopher H van Dyck, Adam P Mecca
OBJECTIVE: Multimodal imaging techniques have furthered our understanding of how different aspects of Alzheimer's disease (AD) pathology relate to one another. Diffusion tensor imaging (DTI) measures such as mean diffusivity (MD) may be a surrogate measure of the changes in gray matter structure associated with AD. Positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) has been used to quantify synaptic loss, which is the major pathological correlate of cognitive impairment in AD...
August 11, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37640577/genetically-proxied-sarcopenia-related-muscle-traits-and-depression-evidence-from-the-finngen-cohort
#13
JOURNAL ARTICLE
Zhengtao Lv, Yingchao Zhao, Jiarui Cui, Jiaming Zhang
BACKGROUND: Sarcopenia and depression are common and often coexist in the elderly. This study aims to determine the impact of sarcopenia-related muscle traits on depression. METHODS: A two-sample Mendelian randomization (MR) study was performed on the summary-level data from the FinnGen cohort to estimate the causal association of appendicular lean mass (ALM), walking pace, or low hand grip strength with depression. Additionally, multivariable MR (MVMR) was performed to assess the dependence of each muscle trait in the causality and adjust the effect of body mass index (BMI)...
August 9, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37620206/advanced-research-institute-ari-supporting-the-geriatric-mental-health-research-pipeline
#14
JOURNAL ARTICLE
Jo Anne Sirey, Renee Pepin, Howard Aizenstein, Warren D Taylor, Brent Forester, Olivia Okereke, Amy L Byers, Martha L Bruce
The Advanced Research Institute (ARI) in Mental Health and Aging is a NIMH-funded mentoring network to help transition early-career faculty to independent investigators and scientific leaders. Since 2004, ARI has enrolled 184 Scholars from 61 institutions across 34 states. We describe the ARI components and assess the impact and outcomes of ARI on research careers of participants. Outcomes of ARI graduates (n = 165) came from NIH Reporter, brief surveys, and CVs: 87.3% remained active researchers, 83...
August 5, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37562991/finally-new-hope-for-the-treatment-of-lltrd
#15
EDITORIAL
Marie Anne Gebara, Patrick J Brown, Steven P Roose
No abstract text is available yet for this article.
July 29, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37562992/antidepressants-and-the-risk-of-ischemic-stroke-in-older-adults-according-to-the-degree-of-serotonin-reuptake-inhibition-a-retrospective-cohort-study
#16
JOURNAL ARTICLE
Kyoung-Eun Kwon, Bo Ram Yang, Mi-Sook Kim, Byung-Joo Park, Joongyub Lee, Sun-Young Jung
OBJECTIVE: The effects of serotonin reuptake inhibition induced by antidepressants on ischemic stroke and its pathophysiology remain unclear despite the frequent use of antidepressants and high fatality of ischemic stroke. We estimated the risk of ischemic stroke associated with antidepressant use in older adults according to the degree of serotonin reuptake inhibition. DESIGN: Retrospective cohort study. PARTICIPANTS: The cohort consisted of older adult patients who were treated with antidepressants...
July 28, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37543462/underscoring-the-significance-of-memorial-attendance-in-reducing-future-psychological-distress-in-bereaved-older-women
#17
EDITORIAL
Joseph S Goveas
No abstract text is available yet for this article.
July 27, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37544835/neuropsychiatric-symptoms-and-alzheimer-disease-biomarkers-independently-predict-progression-to-incident-cognitive-impairment
#18
JOURNAL ARTICLE
Ganesh M Babulal, Ling Chen, Samantha A Murphy, Jason M Doherty, Ann M Johnson, John C Morris
OBJECTIVES: To investigate the effect of neuropsychiatric symptoms and depression symptoms, respectively, and Alzheimer disease (AD) biomarkers (cerebrospinal fluid [CSF] or Positron Emission Tomography [PET] imaging) on the progression to incident cognitive impairment among cognitively normal older adults. DESIGN: Prospective, observation, longitudinal study. SETTING: Knight Alzheimer Disease Research Center (ADRC) at Washington University School of Medicine...
July 26, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37567839/the-efficacy-of-ramelteon-to-prevent-postoperative-delirium-after-general-anesthesia-in-the-elderly-a-double-blind-randomized-placebo-controlled-trial
#19
JOURNAL ARTICLE
Mariko Kinouchi, Takahiro Mihara, Masataka Taguri, Makoto Ogura
OBJECTIVE: Postoperative delirium is common and serious in elderly patients. Several drugs have been proposed as potential prophylactic agents for postoperative delirium. Studies on melatonin receptor agonists showed heterogeneity in age, cognitive function, anesthesia, surgery, interventions, methodologies for assessing outcomes, and results. Our objective was to examine the effect of ramelteon to prevent postoperative delirium in elderly patients, including those with dementia. DESIGN: A stratified, double-blind, randomized, placebo-controlled trial (UMIN000028436, jRCTs031180054)...
July 24, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37543463/reconceptualizing-catatonia-as-psychiatric-parkinsonism
#20
EDITORIAL
Jared T Hinkle, Gregory M Pontone
No abstract text is available yet for this article.
July 23, 2023: American Journal of Geriatric Psychiatry
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