Jason A Silva-Rudberg, Elaheh Salardini, Ryan S O'Dell, Ming-Kai Chen, Jocelyn Ra, Jamie K Georgelos, Mackenzie R Morehouse, Kaitlyn P Melino, Pradeep Varma, Takuya Toyonaga, Nabeel B Nabulsi, Yiyun Huang, Richard E Carson, Christopher H van Dyck, Adam P Mecca
OBJECTIVE: Multimodal imaging techniques have furthered our understanding of how different aspects of Alzheimer's disease (AD) pathology relate to one another. Diffusion tensor imaging (DTI) measures such as mean diffusivity (MD) may be a surrogate measure of the changes in gray matter structure associated with AD. Positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) has been used to quantify synaptic loss, which is the major pathological correlate of cognitive impairment in AD...
August 11, 2023: American Journal of Geriatric Psychiatry