Emma L Twait, Maria Kamarioti, Inge M W Verberk, Charlotte E Teunissen, Astrid C J Nooyens, W M Monique Verschuren, Pieter Jelle Visser, Martijn Huisman, Almar A L Kok, P Eline Slagboom, Marian Beekman, Dina Vojinovic, Nico Lakenberg, M Arfan Ikram, Isabel K Schuurmans, Frank J Wolters, Justine E F Moonen, Lotte Gerritsen, Wiesje M van der Flier, Mirjam I Geerlings
BACKGROUND: Depressive symptoms are associated with an increased risk of Alzheimer's disease (AD). There has been a recent emergence in plasma biomarkers for AD pathophysiology, such as amyloid-beta (Aβ) and phosphorylated tau (p-tau), as well as for axonal damage (neurofilament light, NfL) and astrocytic activation (glial fibrillary acidic protein, GFAP). Hypothesizing that depressive symptoms may occur along the AD process, we investigated associations between plasma biomarkers of AD with depressive symptoms in individuals without dementia...
March 11, 2024: American Journal of Geriatric Psychiatry